MCID: SBC035
MIFTS: 35

Subacute Cutaneous Lupus Erythematosus malady

Skin diseases category

Summaries for Subacute Cutaneous Lupus Erythematosus

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63Wikipedia, 32MalaCards
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Wikipedia:63 Subacute cutaneous lupus erythematosus (SCLE) is a clinically distinct subset of cases of lupus... more...

MalaCards: Subacute Cutaneous Lupus Erythematosus, also known as lupus erythematosus, subacute cutaneous, is related to lupus erythematosus and systemic lupus erythematosus. An important gene associated with Subacute Cutaneous Lupus Erythematosus is C1QA (complement component 1, q subcomponent, A chain), and among its related pathways are Tuberculosis and Apoptosis Modulation and Signaling. The compounds alefacept and efalizumab have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are mortality/aging and hematopoietic system.

Aliases & Classifications for Subacute Cutaneous Lupus Erythematosus

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Sources:
48Orphanet, 60UMLS, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

subacute cutaneous lupus erythematosus 48
lupus erythematosus, subacute cutaneous 60


External Ids:

ICD10 via Orphanet26 L93.1
SNOMED-CT via Orphanet57 239891002
UMLS via Orphanet61 C0024140
ICD1025 L93.1

Related Diseases for Subacute Cutaneous Lupus Erythematosus

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17GeneCards, 18GeneDecks
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Diseases in the Cutaneous Lupus Erythematosus family:

subacute cutaneous lupus erythematosus

Diseases related to Subacute Cutaneous Lupus Erythematosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus32.2IFNA2, APOH
2systemic lupus erythematosus31.1CD70, TYK2, TRIM21, CTLA4, APOH, IRF5
3arthritis30.9TNF, CTLA4
4rheumatoid arthritis30.8TNF, IRF5, APOH, CTLA4, TRIM21, TYK2
5vasculitis30.8IFNA2, TNF, APOH, CTLA4, TRIM21
6psoriasis30.7CTLA4, TNF
7lichen planus30.6IFNA2
8mixed connective tissue disease30.4APOH
9crohn's disease30.4TNF
10dermatitis30.4CTLA4
11sjogren's syndrome30.4APOH, TRIM21
12skin disease30.4PRF1, IFNA1
13hepatitis30.4CTLA4, IFNA1, IFNA2
14hepatitis b30.4CTLA4, IFNA1, IFNA2
15connective tissue disease30.3TRIM21, CTLA4, APOH, TNF, IFNA1
16cutaneous lupus erythematosus11.5
17porphyria cutanea tarda10.6
18cutaneous porphyria10.6
19porphyria10.6
20erythema multiforme10.4
21complement deficiency10.4
22myositis10.4
23tinea corporis10.4
24acute pancreatitis10.3
25molluscum contagiosum10.3
26hereditary angioedema10.3
27epidermolysis bullosa acquisita10.3
28keratoconjunctivitis sicca10.3
29inclusion body myositis10.3
30skin meningioma10.3
31pityriasis rubra pilaris10.3
32herpes zoster10.3
33adenocarcinoma10.3
34angioedema10.3
35eosinophilia10.3
36epidermolysis bullosa10.3
37hepatocellular carcinoma10.3
38hypertrichosis10.3
39keratoconjunctivitis10.3
40lung cancer10.3
41lymphadenitis10.3
42melanoma10.3
43meningioma10.3
44pancreatitis10.3
45panniculitis10.3
46prostatitis10.3
47renal cell carcinoma10.3
48squamous cell carcinoma10.3
49myocarditis10.0PRF1
50hemophagocytic lymphohistiocytosis10.0PRF1

Graphical network of the top 20 diseases related to Subacute Cutaneous Lupus Erythematosus:



Diseases related to subacute cutaneous lupus erythematosus

Clinical Features for Subacute Cutaneous Lupus Erythematosus

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Drugs & Therapeutics for Subacute Cutaneous Lupus Erythematosus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Subacute Cutaneous Lupus Erythematosus

Drug clinical trials:

Search ClinicalTrials for Subacute Cutaneous Lupus Erythematosus

Search NIH Clinical Center for Subacute Cutaneous Lupus Erythematosus

Search CenterWatch for Subacute Cutaneous Lupus Erythematosus

Genetic Tests for Subacute Cutaneous Lupus Erythematosus

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Anatomical Context for Subacute Cutaneous Lupus Erythematosus

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32MalaCards
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MalaCards organs/tissues related to Subacute Cutaneous Lupus Erythematosus:

32
Skin

Animal Models for Subacute Cutaneous Lupus Erythematosus or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Subacute Cutaneous Lupus Erythematosus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.0MBD3, MBD4, TNF, APOH, CTLA4, PRF1
2MP:00053976.8TNF, IRF5, CTLA4, PRF1, TRIM21, TYK2
3MP:00053766.7IRF5, TNF, MBD4, MBD3, APOH, CTLA4
4MP:00053846.7ACE, C1QA, MBD3, MBD4, MBD1, TNF
5MP:00053876.6IRF5, TNF, MBD3, C1QA, CTLA4, PRF1

Publications for Subacute Cutaneous Lupus Erythematosus

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Genetic Variations for Subacute Cutaneous Lupus Erythematosus

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Expression for genes affiliated with Subacute Cutaneous Lupus Erythematosus

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Subacute Cutaneous Lupus Erythematosus

Search GEO for disease gene expression data for Subacute Cutaneous Lupus Erythematosus.

Pathways for genes affiliated with Subacute Cutaneous Lupus Erythematosus

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Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 51QIAGEN
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Pathways related to Subacute Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7EEA1, TNF
2
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9.4PRF1, IRF5, TNF
3
Immune response IFN alpha/beta signaling pathway
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9.2TYK2, IRF5, IFNA2
4
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9.0TRIM21, IFNA1, IFNA2
58.9TNF, IFNA1, IFNA2
6
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8.9IFNA2, IFNA1, TNF
78.8IFNA2, IFNA1, TYK2
8
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8.7IFNA2, IFNA1, TNF, PRF1
9
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8.6IFNA1, TYK2, CD70
10
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8.4TYK2, TNF, IFNA1, IFNA2
118.4IFNA2, IFNA1, TNF, TYK2
12
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8.3TYK2, IRF5, IFNA1, IFNA2
13
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8.0IFNA2, IFNA1, TNF, CTLA4, PRF1
14
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7.8ACE, IRF5, TNF, IFNA1, IFNA2, C1QA
15
Hide members
7.2C1QA, IFNA2, IFNA1, IRF5, CTLA4, TRIM21

Compounds for genes affiliated with Subacute Cutaneous Lupus Erythematosus

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Subacute Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1alefacept44 1111.1C1QA, TNF
2efalizumab44 1111.0C1QA, TNF
3hydroxychloroquine44 1110.8APOH, TNF, IFNA2
4abatacept44 1110.8CTLA4, TNF
5procainamide44 1110.8APOH, CD70
6natalizumab44 1110.7C1QA, TNF
7pegasys449.7IFNA1, IFNA2
8entecavir449.7IFNA2, IFNA1
9mizoribine449.7IFNA2, IFNA1
10famciclovir44 1110.7IFNA2, IFNA1
11intron a449.7IFNA2, IFNA1
12n-phosphonacetyl-l-aspartate449.7IFNA2, IFNA1
13anagrelide44 1110.6IFNA2, IFNA1
14atpo44 2810.6IFNA1, APOH
15pentostatin44 59 28 1112.6IFNA2, IFNA1
16lomustine44 1110.6IFNA2, IFNA1
17etanercept44 49 1111.6C1QA, IFNA2, TNF, APOH
18rantes449.6IFNA1, TNF
195-deoxy-5-fluorouridine449.6IFNA2, IFNA1
20adefovir449.6IFNA1, IFNA2
21amantadine44 1110.5IFNA2, IFNA1
22didanosine44 1110.3IFNA1, IFNA2
23acitretin44 1110.3IFNA1, IFNA2
24imiquimod44 28 59 1112.3TNF, IFNA1, IFNA2
252,5-oligoadenylate449.3TNF, IFNA1, IFNA2
26melphalan44 1110.2TNF, IFNA1, IFNA2
27neopterin449.2IFNA2, IFNA1, TNF
28chloroquine44 2 49 28 1113.2IFNA1, TNF, EEA1
29infliximab44 49 1111.2IFNA2, TNF, APOH, CTLA4
30ifn-alpha449.1TYK2, IFNA1, IFNA2
31glatiramer acetate44 1110.1CTLA4, IFNA1
32busulfan44 1110.0IFNA1, IFNA2
33zinc44 2410.0IFNA2, MBD4, APOH, TRIM21, ACE, EEA1
34prednisolone44 28 1111.0IFNA2, IFNA1, TNF, APOH
35cholesterol44 28 11 2411.9EEA1, ACE, PRF1, CTLA4, APOH
36thalidomide44 49 59 1111.7IFNA2, IFNA1, TNF, CTLA4
37lipid448.3EEA1, ACE, CTLA4, APOH, TNF, IFNA2
38vegf448.3APOH, IRF5, TNF, IFNA1, IFNA2
39rituximab44 49 1110.2CTLA4, APOH, TNF, IFNA1, IFNA2, C1QA

GO Terms for genes affiliated with Subacute Cutaneous Lupus Erythematosus

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Sources:
16Gene Ontology
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Biological processes related to Subacute Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:0516079.4PRF1, IRF5, IFNA2
2type I interferon-mediated signaling pathwayGO:0603378.9TYK2, IRF5, IFNA2

Molecular functions related to Subacute Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055155.1EEA1, IFNA2, MBD3, MBD4, MBD1, TNF

Products for genes affiliated with Subacute Cutaneous Lupus Erythematosus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Subacute Cutaneous Lupus Erythematosus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet