MCID: SBC035
MIFTS: 51

Subacute Cutaneous Lupus Erythematosus malady

Skin diseases, Rare diseases, Immune diseases categories
Download this MalaCard

Summaries for Subacute Cutaneous Lupus Erythematosus

About this section


Fully expand this MalaCard
Wikipedia:65 Subacute cutaneous lupus erythematosus (SCLE) is a clinically distinct subset of cases of lupus... more...

MalaCards based summary: Subacute Cutaneous Lupus Erythematosus, also known as lupus erythematosus, subacute cutaneous, is related to lupus erythematosus and systemic lupus erythematosus. An important gene associated with Subacute Cutaneous Lupus Erythematosus is C1QA (complement component 1, q subcomponent, A chain), and among its related pathways are Immune response IL 12 signaling pathway and Regulation of autophagy. The compounds pegasys and alefacept have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and lung, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Subacute Cutaneous Lupus Erythematosus

About this section
Sources:
48Orphanet, 62UMLS, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Subacute Cutaneous Lupus Erythematosus, Aliases & Descriptions:

Name: Subacute Cutaneous Lupus Erythematosus 48
 
Lupus Erythematosus, Subacute Cutaneous 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases, Immune diseases
Orphanet: 48 
Rare skin diseases


External Ids:

ICD10 via Orphanet26 L93.1
UMLS via Orphanet63 C0024140
ICD1025 L93.1

Related Diseases for Subacute Cutaneous Lupus Erythematosus

About this section

Diseases in the Subacute Cutaneous Lupus Erythematosus family:

Cutaneous Lupus Erythematosus

Diseases related to Subacute Cutaneous Lupus Erythematosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus32.7APOH, IFNA2
2systemic lupus erythematosus32.0IRF5
3skin disease30.7IFNA1, PRF1
4vasculitis30.4TNF, APOH, IFNA2, CTLA4, TRIM21
5hepatitis b30.3IFNA1, IFNA2, CTLA4
6rheumatoid arthritis30.3TYK2, TNF, APOH, IRF5, CD70, CTLA4
7hepatitis30.2CTLA4, IFNA2, IFNA1
8connective tissue disease29.8TNF, APOH, IFNA1, CTLA4, TRIM21
9melanoma29.6TNF, PRF1, IFNA1, IFNA2, CD70, CTLA4
10cutaneous lupus erythematosus11.5
11arthritis10.7
12porphyria cutanea tarda10.6
13porphyria10.6
14psoriasis10.5
15discoid lupus erythematosus10.5
16c1q deficiency10.5C1QA
17endophthalmitis10.5PRF1
18endocarditis10.5PRF1
19retinal vasculitis10.5APOH
20retinal artery occlusion10.5APOH
21panuveitis10.5IFNA2
22lichen planus10.5
23myositis10.5
24tinea corporis10.5
25toxic epidermal necrolysis10.5
26degos disease10.5APOH
27polyarteritis nodosa10.5IFNA2
28lymphomatoid granulomatosis10.4IFNA2
29hemophagocytic lymphohistiocytosis10.4PRF1
30myocarditis10.4PRF1
31leprosy10.4MBD1
32stomatitis10.4IFNA2
33cholangiocarcinoma10.3
34crohn's disease10.3
35hepatocellular carcinoma10.3
36renal cell carcinoma10.3
37acute pancreatitis10.3
38hereditary angioedema10.3
39pityriasis rubra pilaris10.3
40erythema multiforme10.3
41epidermolysis bullosa acquisita10.3
42sjogren's syndrome10.3
43molluscum contagiosum10.3
44herpes zoster10.3
45mixed connective tissue disease10.3
46inclusion body myositis10.3
47adenocarcinoma10.3
48angioedema10.3
49dermatitis10.3
50eosinophilia10.3

Graphical network of the top 20 diseases related to Subacute Cutaneous Lupus Erythematosus:



Diseases related to subacute cutaneous lupus erythematosus

Symptoms for Subacute Cutaneous Lupus Erythematosus

About this section

Drugs & Therapeutics for Subacute Cutaneous Lupus Erythematosus

About this section

Drug clinical trials:

Search ClinicalTrials for Subacute Cutaneous Lupus Erythematosus

Search NIH Clinical Center for Subacute Cutaneous Lupus Erythematosus

Genetic Tests for Subacute Cutaneous Lupus Erythematosus

About this section

Anatomical Context for Subacute Cutaneous Lupus Erythematosus

About this section

MalaCards organs/tissues related to Subacute Cutaneous Lupus Erythematosus:

32
Skin, T cells, Lung, Brain, Breast, Prostate, Testes

Animal Models for Subacute Cutaneous Lupus Erythematosus or affiliated genes

About this section

MGI Mouse Phenotypes related to Subacute Cutaneous Lupus Erythematosus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5MBD4, MBD3, ACE, PRF1, TNF
2MP:00053847.4C1QA, TYK2, TNF, PRF1, ACE, MBD3
3MP:00053766.8TYK2, TNF, APOH, IRF5, PRF1, ACE
4MP:00107686.8APOH, TNF, TYK2, C1QA, PRF1, ACE
5MP:00053976.7TYK2, TNF, IRF5, PRF1, ACE, CD70
6MP:00053876.4TRIM21, C1QA, TYK2, TNF, IRF5, PRF1

Publications for Subacute Cutaneous Lupus Erythematosus

About this section

Articles related to Subacute Cutaneous Lupus Erythematosus:

(show top 50)    (show all 271)
idTitleAuthorsYear
1
Subacute cutaneous lupus erythematosus onset preceded by Kikuchi-Fujimoto disease. (24520513)
2014
2
Annular subacute cutaneous lupus erythematosus lesions and polymyositis onset in a patient with primary Sjogren's syndrome: how should this unusual association be classified? (23358869)
2013
3
A case of subacute cutaneous lupus erythematosus in a patient with mixed connective tissue disease: successful treatment with plasmapheresis and rituximab. (23984162)
2013
4
A case of subacute cutaneous lupus erythematosus as a result of ranibizumab (Lucentis) treatment. (24212210)
2013
5
Subacute cutaneous lupus erythematosus after treatment with capecitabine. (22937906)
2013
6
Taxane associated subacute cutaneous lupus erythematosus. (24021438)
2013
7
Toxic epidermal necrolysis-like subacute cutaneous lupus erythematosus. (23157783)
2012
8
Subacute Cutaneous Lupus Erythematosus Presenting in Childhood: A Case Report and Review of the Literature. (23106790)
2012
9
Atypical subacute cutaneous lupus erythematosus presenting as lichen planus pemphigoides with autoantibodies to C-terminus of BP180, desmoglein 1 and SS-A/Ro antigen. (22413755)
2012
10
Consider drugs as a cause or an exacerbating factor in patients diagnosed with subacute cutaneous lupus erythematosus! (22835019)
2012
11
Subacute cutaneous lupus erythematosus due to proton pump inhibitor intake: case report and literature review. (23056090)
2012
12
The interferon-regulated gene signature is elevated in subacute cutaneous lupus erythematosus and discoid lupus erythematosus and correlates with the cutaneous lupus area and severity index score. (22242767)
2012
13
Variable presentations of subacute cutaneous lupus erythematosus. (20642992)
2010
14
Subacute cutaneous lupus erythematosus associated with capecitabine monotherapy. (19289781)
2009
15
Terbinafine-induced subacute cutaneous lupus erythematosus. (18441768)
2008
16
Subacute cutaneous lupus erythematosus and interstitial myositis occurring with hepatitis B infection: response to antiviral therapy with lamivudine. (18664991)
2008
17
Occurrence of subacute cutaneous lupus erythematosus after treatment with fluorouracil and capecitabine. (18625380)
2008
18
Subacute cutaneous lupus erythematosus with bullae associated with porphyria cutanea tarda. (17338797)
2007
19
Subacute cutaneous lupus erythematosus on the lines of Blaschko. (16709500)
2006
20
Subacute cutaneous lupus erythematosus: 25-year evolution of a prototypic subset (subphenotype) of lupus erythematosus defined by characteristic cutaneous, pathological, immunological, and genetic findings. (15990071)
2005
21
Bupropion-induced subacute cutaneous lupus erythematosus. (16197429)
2005
22
Kikuchi's disease (necrotizing lymphadenitis) with cutaneous involvement associated with subacute cutaneous lupus erythematosus. (15115501)
2004
23
Bullous subacute cutaneous lupus erythematosus. (15115507)
2004
24
Successful treatment of subacute cutaneous lupus erythematosus with mycophenolate mofetil. (12100205)
2002
25
Frequency and severity of systemic disease in patients with subacute cutaneous lupus erythematosus. (12224978)
2002
26
Subacute cutaneous lupus erythematosus associated with hepatocellular carcinoma. (11309033)
2001
27
Subacute cutaneous lupus erythematosus presenting with generalized poikiloderma. (10642688)
2000
28
The cutaneous pathology associated with seropositivity for antibodies to SSA (Ro): a clinicopathologic study of 23 adult patients without subacute cutaneous lupus erythematosus. (10218672)
1999
29
Lichenoid and subacute cutaneous lupus erythematosus-like dermatitis associated with antihistamine therapy. (10082400)
1999
30
Paraneoplastic subacute cutaneous lupus erythematosus: report of a case associated with cancer of the lung. (9094469)
1997
31
Rapid improvement of subacute cutaneous lupus erythematosus with low-dose methotrexate. (9187859)
1997
32
Leukocytoclastic vasculitis in subacute cutaneous lupus erythematosus: clinicopathologic study of three cases and review of the literature. (8944346)
1996
33
Childhood subacute cutaneous lupus erythematosus associated with homozygous complement 2 deficiency. (8747579)
1995
34
Subacute cutaneous lupus erythematosus associated with chronic interstitial pneumonitis. (7607798)
1995
35
Coexisting lichen planus and subacute cutaneous lupus erythematosus. (7671426)
1995
36
Pityriasis rubra pilaris presenting as subacute cutaneous lupus erythematosus. (8243104)
1993
37
A characteristic cutaneous direct immunofluorescent pattern associated with Ro(SS-A) antibodies in subacute cutaneous lupus erythematosus. (1430355)
1992
38
Possible naproxen-induced relapse of subacute cutaneous lupus erythematosus. (1535107)
1992
39
Detection of anti-Ro(SSA) antibodies by gel double diffusion and a 'sandwich' ELISA in systemic and subacute cutaneous lupus erythematosus and SjAPgren's syndrome. (1903247)
1991
40
Response of discoid and subacute cutaneous lupus erythematosus to recombinant interferon alpha 2a. (2258631)
1990
41
IgG subclasses in the serum and skin in subacute cutaneous lupus erythematosus and neonatal lupus erythematosus. (2250107)
1990
42
Comparison of IgG subclass autoantibodies in patients with systemic lupus erythematosus and subacute cutaneous lupus erythematosus. (2085508)
1990
43
Subacute cutaneous lupus erythematosus in Greece. A clinical, serological and genetic study. (2256585)
1990
44
Pattern of cutaneous immunoglobulin G deposition in subacute cutaneous lupus erythematosus is reproduced by infusing purified anti-Ro (SSA) autoantibodies into human skin-grafted mice. (2651477)
1989
45
Subacute cutaneous lupus erythematosus presenting as erythroderma. (2970478)
1988
46
Subacute cutaneous lupus erythematosus. Clinical, serologic, immunogenetic, and therapeutic considerations in seventy-two patients. (3261587)
1988
47
A monoclonal Ro-antibody and the serum of a Ro-positive patient with subacute cutaneous lupus erythematosus (SCLE) react with basal layers of human epidermis. (3147897)
1988
48
Subacute cutaneous lupus erythematosus. (3880024)
1985
49
Relationships between antinuclear and anti-Ro/SS-A antibodies in subacute cutaneous lupus erythematosus. (6384294)
1984
50
Human histocompatibility antigen associations in subacute cutaneous lupus erythematosus. (7451656)
1981

Variations for Subacute Cutaneous Lupus Erythematosus

About this section

Expression for genes affiliated with Subacute Cutaneous Lupus Erythematosus

About this section
Expression patterns in normal tissues for genes affiliated with Subacute Cutaneous Lupus Erythematosus

Search GEO for disease gene expression data for Subacute Cutaneous Lupus Erythematosus.

Pathways for genes affiliated with Subacute Cutaneous Lupus Erythematosus

About this section

Pathways related to Subacute Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TYK2, PRF1
29.5IFNA2, IFNA1
39.5IFNA2, IFNA1
49.5TNF, TYK2
5
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
9.3PRF1, IRF5, TNF
6
Show member pathways
9.2IFNA1, IFNA2, TRIM21
7
Show member pathways
Type III interferon signaling37
9.2TYK2, IFNA1, IFNA2
89.2IFNA2, IFNA1, TYK2
9
Show member pathways
9.0TRIM21, MBD3, TNF, C1QA
10
Show member pathways
9.0TYK2, IRF5, IFNA1, IFNA2
11
Show member pathways
9.0TYK2, IRF5, IFNA1, IFNA2
12
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.9IFNA2, IFNA1, TNF
138.9IFNA2, IFNA1, TNF
14
Show member pathways
8.9IFNA2, IFNA1, TNF
158.9IFNA2, IFNA1, TNF
16
Show member pathways
Immune response CD16 signaling in NK cells60
8.6TNF, PRF1, IFNA1, IFNA2
178.6TYK2, TNF, IFNA1, IFNA2
18
Show member pathways
8.6TYK2, TNF, IFNA1, IFNA2
19
Show member pathways
8.6TYK2, TNF, IFNA1, IFNA2
20
Show member pathways
8.2CTLA4, IFNA2, IFNA1, PRF1, TNF
21
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
7.9ACE, IFNA2, IFNA1, IRF5, TNF, C1QA
22
Show member pathways
7.8CD70, IFNA2, IFNA1, TNF, TYK2

Compounds for genes affiliated with Subacute Cutaneous Lupus Erythematosus

About this section

Compounds related to Subacute Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1pegasys4410.0IFNA2, IFNA1
2alefacept44 1111.0TNF, C1QA
3entecavir4410.0IFNA2, IFNA1
4efalizumab44 1111.0TNF, C1QA
5famciclovir44 1110.9IFNA1, IFNA2
6n-phosphonacetyl-l-aspartate449.9IFNA1, IFNA2
7intron a449.9IFNA1, IFNA2
8atpo28 4410.9IFNA1, APOH
9mizoribine449.9IFNA1, IFNA2
10pentostatin44 61 28 1112.9IFNA1, IFNA2
11lomustine44 1110.9IFNA1, IFNA2
12anagrelide44 1110.9IFNA1, IFNA2
135-deoxy-5-fluorouridine449.9IFNA2, IFNA1
14natalizumab44 1110.9TNF, C1QA
15adefovir449.9IFNA1, IFNA2
16amantadine44 1110.9IFNA1, IFNA2
17didanosine44 50 1111.8IFNA2, IFNA1
18abatacept44 1110.8TNF, CTLA4
19acitretin44 1110.8IFNA2, IFNA1
20glatiramer acetate44 1110.8IFNA1, CTLA4
21busulfan44 50 1111.7IFNA1, IFNA2
22levamisole44 1110.7IFNA1, IFNA2
23dacarbazine44 1110.7IFNA1, IFNA2
24ifn-alpha449.6IFNA2, IFNA1, TYK2
25procainamide44 1110.6APOH, CD70
26hydroxychloroquine44 1110.5IFNA2, APOH, TNF
275-aza-2deoxycytidine449.5IFNA1, MBD1, MBD4
28acyclovir44 1110.4IFNA2, IFNA1
29cyclophosphamide44 50 1111.4APOH, IFNA1, IFNA2
30imiquimod44 61 28 1112.4TNF, IFNA1, IFNA2
312,5-oligoadenylate449.3IFNA2, IFNA1, TNF
32neopterin449.3TNF, IFNA1, IFNA2
33indoleamine449.3CTLA4, IFNA1, TNF
34mycophenolate mofetil44 50 1111.3TNF, IFNA1, CTLA4
35etanercept44 50 1111.3C1QA, TNF, APOH, IFNA2
36hydralazine44 50 1111.3ACE, CD70
37superoxide44 2410.1TNF, APOH, PRF1, IFNA2
38infliximab44 50 1111.1CTLA4, IFNA2, APOH, TNF
39il-12449.0IFNA1, TNF
40prednisolone44 28 1111.0TNF, APOH, IFNA1, IFNA2
41zinc44 2410.0APOH, IFNA2, ACE, MBD4, TRIM21
42prostacyclin449.0TNF, APOH, ACE
43melphalan44 50 1110.9TNF, IFNA1, IFNA2, CTLA4
44thalidomide44 50 61 1111.9TNF, IFNA1, IFNA2, CTLA4
45tacrolimus44 50 1110.9CTLA4, IFNA1, TNF
46ionomycin448.8TNF, CD70, CTLA4
47thymidine44 249.8CTLA4, IFNA2, IFNA1, TNF
48vegf448.7TNF, APOH, IRF5, IFNA1, IFNA2
49rantes448.5CTLA4, CD70, IFNA1, TNF
50rituximab44 50 1110.3CTLA4, IFNA2, IFNA1, APOH, TNF, C1QA

GO Terms for genes affiliated with Subacute Cutaneous Lupus Erythematosus

About this section

Cellular components related to Subacute Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9CTLA4, ACE, TNF
2extracellular spaceGO:0056157.4CD70, ACE, IFNA2, APOH, TNF

Biological processes related to Subacute Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of type I interferon-mediated signaling pathwayGO:0603389.7IFNA2, TYK2
2type I interferon signaling pathwayGO:0603379.6IFNA2, IRF5, TYK2
3defense response to virusGO:0516079.6IFNA2, PRF1, IRF5
4cytokine-mediated signaling pathwayGO:0192219.4TYK2, IRF5, IFNA2
5extrinsic apoptotic signaling pathwayGO:0971919.0CD70, TNF
6cell-cell signalingGO:0072678.7CD70, IFNA2, C1QA

Molecular functions related to Subacute Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1methyl-CpG bindingGO:0083279.8MBD3, MBD1
2tumor necrosis factor receptor bindingGO:0051649.0CD70, TNF
3cytokine activityGO:0051258.3CD70, IFNA2, TNF
4protein bindingGO:0055155.0TRIM21, C1QA, TYK2, TNF, APOH, IRF5

Products for genes affiliated with Subacute Cutaneous Lupus Erythematosus

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Subacute Cutaneous Lupus Erythematosus

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet