MCID: SBC035
MIFTS: 34

Subacute Cutaneous Lupus Erythematosus malady

Categories: Skin diseases, Rare diseases, Immune diseases

Aliases & Classifications for Subacute Cutaneous Lupus Erythematosus

Aliases & Descriptions for Subacute Cutaneous Lupus Erythematosus:

Name: Subacute Cutaneous Lupus Erythematosus 56
Lupus Erythematosus, Subacute Cutaneous 69
Lupus Erythematosus Cutaneous Subacute 52

Characteristics:

Orphanet epidemiological data:

56
subacute cutaneous lupus erythematosus
Prevalence: 1-9/1000000 (United States);

Classifications:

Orphanet: 56  
Rare skin diseases


External Ids:

Orphanet 56 ORPHA163525
ICD10 via Orphanet 34 L93.1
UMLS via Orphanet 70 C0024140
ICD10 33 L93.1

Summaries for Subacute Cutaneous Lupus Erythematosus

MalaCards based summary : Subacute Cutaneous Lupus Erythematosus, also known as lupus erythematosus, subacute cutaneous, is related to lupus erythematosus and cutaneous lupus erythematosus. An important gene associated with Subacute Cutaneous Lupus Erythematosus is TRIM21 (Tripartite Motif Containing 21), and among its related pathways/superpathways is Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Alitretinoin and Tretinoin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and breast.

Wikipedia : 71 Subacute cutaneous lupus erythematosus (SCLE) is a clinically distinct subset of cases of lupus... more...

Related Diseases for Subacute Cutaneous Lupus Erythematosus

Diseases in the Cutaneous Lupus Erythematosus family:

Subacute Cutaneous Lupus Erythematosus

Diseases related to Subacute Cutaneous Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
id Related Disease Score Top Affiliating Genes
1 lupus erythematosus 11.0
2 cutaneous lupus erythematosus 11.0
3 systemic lupus erythematosus 10.3
4 arthritis 10.1
5 rheumatoid arthritis 10.1
6 porphyria 10.1
7 vasculitis 10.1
8 psoriasis 10.1
9 porphyria cutanea tarda 10.1
10 hypoparathyroidism-retardation-dysmorphism syndrome 10.1 TNF TRIM21
11 pneumoconiosis 10.1 TNF TRIM21
12 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.1 TNF TRIM21
13 splenic artery aneurysm 10.1 TNF TRIM21
14 lymph node adenoid cystic carcinoma 10.0 TNF TRIM21
15 discoid lupus erythematosus 10.0
16 respiratory system disease 10.0 TNF TRIM21
17 cardiac sarcoidosis 10.0 ACE TNF
18 dermatosis papulosa nigra 10.0 ACE TNF
19 preaxial polydactyly of fingers 10.0 ACE TNF
20 juvenile amyotrophic lateral sclerosis with dementia 10.0 ACE TNF
21 joint disorders 10.0 ACE TNF
22 tuberculosis 10.0 ACE TNF
23 peripheral artery disease 10.0 ACE TNF
24 newcastle disease 10.0 ACE TNF
25 alcoholic hepatitis 10.0 ACE TNF
26 oppositional defiant disorder 10.0 ACE TNF
27 choroiditis 10.0 ACE TNF
28 skin conditions 10.0 ACE TNF
29 retinal ischemia 10.0 ACE TNF
30 pyelonephritis 10.0 ACE TNF
31 limb ischemia 10.0 ACE TNF
32 familial nephrotic syndrome 9.9 ACE TNF
33 diabetic encephalopathy 9.9 ACE TNF
34 microscopic breast papilloma 9.9 ACE TNF
35 myositis 9.9
36 c2 deficiency 9.9
37 neuropathy 9.9
38 squamous cell carcinoma 9.9
39 hepatitis 9.9
40 lichen planus 9.9
41 erythema multiforme 9.9
42 tinea corporis 9.9
43 deafness, autosomal recessive 67 9.9 ACE TNF
44 familial periodic paralysis 9.9 ACE TRIM21
45 biliary cirrhosis, primary, 2 9.9 ACE TNF
46 articulation disorder 9.9 TNF TRIM21
47 acute chest syndrome 9.9 ACE TNF
48 powassan encephalitis 9.9 EEA1 TNF TRIM21
49 anogenital venereal wart 9.9 ACE TNF
50 calcinosis 9.9 ACE TNF

Graphical network of the top 20 diseases related to Subacute Cutaneous Lupus Erythematosus:



Diseases related to Subacute Cutaneous Lupus Erythematosus

Symptoms & Phenotypes for Subacute Cutaneous Lupus Erythematosus

Drugs & Therapeutics for Subacute Cutaneous Lupus Erythematosus

Drugs for Subacute Cutaneous Lupus Erythematosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alitretinoin Approved, Investigational Phase 2 5300-03-8 444795
2
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538
3 Dermatologic Agents Phase 2
4 Keratolytic Agents Phase 2
5 tyrosine Nutraceutical Phase 1
6
Tacrolimus Approved, Investigational 104987-11-3 445643 439492
7
Pimecrolimus Approved, Investigational 137071-32-0 6447131 17753757
8 Analgesics
9 Analgesics, Non-Narcotic
10 Peripheral Nervous System Agents
11 Immunosuppressive Agents
12 Anti-Inflammatory Agents
13 Anti-Inflammatory Agents, Non-Steroidal
14 Antirheumatic Agents
15 Calcineurin Inhibitors

Interventional clinical trials:


id Name Status NCT ID Phase
1 Safety and Efficacy of KRP203 in Subacute Cutaneous Lupus Erythematosus Completed NCT01294774 Phase 2
2 To Evaluate the Preliminary Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of CC-11050 in Subjects With Discoid Lupus Erythematosus and Subacute Cutaneous Lupus Erythematosus Completed NCT01300208 Phase 2
3 Efficacy and Safety of Oral Alitretinoin (Toctino®) in the Treatment of Patients With Cutaneous Lupus Erythematosus Terminated NCT01407679 Phase 2
4 Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Clinical Effect of GSK2646264 in Cutaneous Lupus Erythematosus Patients Recruiting NCT02927457 Phase 1
5 Safety Study of AMG 557 in Subjects With Subacute Cutaneous Lupus Erythematosus Terminated NCT01389895 Phase 1
6 Cutaneous Lupus Erythematosus and Elidel Unknown status NCT00222183
7 Pilot Tape Harvesting Study Completed NCT02125695
8 A Non-drug Study Profiling Cutaneous Lupus Completed NCT01923415 Early Phase 1
9 A Study of Skin and Systemic Biomarkers In Patients With Active Cutaneous Lupus Erythematosus And In Healthy Volunteers Completed NCT02034344 Early Phase 1
10 The Human Microbiome in Immune-Mediated Diseases Recruiting NCT02394964

Search NIH Clinical Center for Subacute Cutaneous Lupus Erythematosus

Genetic Tests for Subacute Cutaneous Lupus Erythematosus

Anatomical Context for Subacute Cutaneous Lupus Erythematosus

MalaCards organs/tissues related to Subacute Cutaneous Lupus Erythematosus:

39
Skin, T Cells, Breast, Lung, Colon, Testes, Prostate

Publications for Subacute Cutaneous Lupus Erythematosus

Articles related to Subacute Cutaneous Lupus Erythematosus:

(show top 50) (show all 301)
id Title Authors Year
1
Rowell's Syndrome or subacute cutaneous lupus erythematosus? ( 27978611 )
2017
2
Drug-Induced Subacute Cutaneous Lupus Erythematosus Associated with Proton Pump Inhibitors. ( 27398293 )
2016
3
Rare Occurrence of Drug Induced Subacute Cutaneous Lupus Erythematosus with Leflunomide Therapy. ( 27891379 )
2016
4
Anastrozole-induced subacute cutaneous lupus erythematosus. ( 27622265 )
2016
5
First case of paraneoplastic subacute cutaneous lupus erythematosus associated with colon cancer. ( 27836354 )
2016
6
Dermoscopy of subacute cutaneous lupus erythematosus. ( 27260752 )
2016
7
Subacute cutaneous lupus erythematosus. ( 27286780 )
2016
8
Gemcitabine-Induced Subacute Cutaneous Lupus Erythematosus: A Case Report. ( 26928175 )
2016
9
Proton Pump Inhibitor-Associated Subacute Cutaneous Lupus Erythematosus in a Patient With Granulomatosis With Polyangiitis. ( 27870768 )
2016
10
Subacute cutaneous lupus erythematosus inducing unilateral sensorimotor neuropathy. ( 27888319 )
2016
11
Voriconazole-Induced Subacute Cutaneous Lupus Erythematosus in an Adult With Aspergillosis. ( 28031137 )
2016
12
Lenalidomide for refractory chronic and subacute cutaneous lupus erythematosus: 16 patients. ( 27185425 )
2016
13
Using the American College of Rheumatology (ACR) and Systemic Lupus International Collaborating Clinics (SLICC) criteria to determine the diagnosis of systemic lupus erythematosus (SLE) in patients with subacute cutaneous lupus erythematosus (SCLE). ( 26897388 )
2016
14
Subacute cutaneous lupus erythematosus starting as linear lupus erythematosus. ( 26235783 )
2015
15
Subacute cutaneous lupus erythematosus induced by capecitabine: 5-FU was innocent. ( 26551520 )
2015
16
Imiquimod-induced subacute cutaneous lupus erythematosus-like changes. ( 26125212 )
2015
17
Subacute Cutaneous Lupus Erythematosus Induced by Mitotane. ( 26444320 )
2015
18
Drug-Induced Subacute Cutaneous Lupus Erythematosus in a Patient Receiving Therapy for Chronic Hepatitis C. ( 26539906 )
2015
19
Subacute cutaneous lupus erythematosus induced by lansoprazole. ( 25855412 )
2015
20
Minocycline: a new molecule inducing subacute cutaneous lupus erythematosus? ( 25876148 )
2015
21
Docetaxel-induced-like subacute cutaneous lupus erythematosus. ( 26350359 )
2015
22
Patient with terbinafine-induced subacute cutaneous lupus erythematosus followed by thalidomide-induced orofacial neuropathy; Beta blocker use, hypertension, and the risk of psoriasis; eczematous reaction to intravenous immunoglobulin; nicolau syndrome after intra-articular glucocorticoid injection; troponin leak associated with drug-induced methemoglobinemia. ( 25684795 )
2015
23
Subacute cutaneous lupus erythematosus induced by the new multikinase inhibitor pazopanib. ( 24909204 )
2014
24
The concurrence of subacute cutaneous lupus erythematosus and hand-foot syndrome in a patient undergoing capecitabine chemotherapy. ( 25495707 )
2014
25
Subacute cutaneous lupus erythematosus: a paraneoplastic phenomenon in oropharyngeal squamous cell carcinoma. ( 25284285 )
2014
26
Subacute cutaneous lupus erythematosus associated with pemetrexed plus Carboplatin chemotherapy. ( 25417687 )
2014
27
Proton pump inhibitors and subacute cutaneous lupus erythematosus: an under-recognized phenomenon? ( 24547716 )
2014
28
Drug-induced subacute cutaneous lupus erythematosus associated with docetaxel chemotherapy: a case report. ( 25369825 )
2014
29
Subacute cutaneous lupus erythematosus onset preceded by Kikuchi-Fujimoto disease. ( 24520513 )
2014
30
Paraneoplastic subacute cutaneous lupus erythematosus associated with cholangiocarcinoma. ( 25367767 )
2014
31
Pediatric subacute cutaneous lupus erythematosus: report of three cases. ( 25209420 )
2014
32
An uncommon cutaneous reaction for a common drug. Diagnosis: Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE). ( 25244994 )
2014
33
What is your diagnosis? subacute cutaneous lupus erythematosus. ( 24818184 )
2014
34
Proton pump inhibitor-induced subacute cutaneous lupus erythematosus. ( 24547721 )
2014
35
Subacute cutaneous lupus erythematosus presenting as erythroderma. ( 25484433 )
2014
36
Drug-induced subacute cutaneous lupus erythematosus due to treatment with interferon beta-1a. ( 24045357 )
2013
37
Taxane associated subacute cutaneous lupus erythematosus. ( 24021438 )
2013
38
A case of subacute cutaneous lupus erythematosus as a result of ranibizumab (Lucentis) treatment. ( 24212210 )
2013
39
Docetaxel-induced relapse of subacute cutaneous lupus erythematosus and chilblain lupus. ( 23848065 )
2013
40
Subacute cutaneous lupus erythematosus triggered by radiotherapy. ( 24019776 )
2013
41
A case of subacute cutaneous lupus erythematosus in a patient with mixed connective tissue disease: successful treatment with plasmapheresis and rituximab. ( 23984162 )
2013
42
Subacute cutaneous lupus erythematosus after treatment with capecitabine. ( 22937906 )
2013
43
Drug-induced subacute cutaneous lupus erythematosus associated with nab-paclitaxel therapy. ( 24155645 )
2013
44
Paraneoplastic subacute cutaneous lupus erythematosus: an underrecognized entity. ( 23461055 )
2013
45
Subacute cutaneous lupus erythematosus in the course of rheumatoid arthritis: a relationship with TNF-I+ antagonists and rituximab therapy? ( 23537059 )
2013
46
Capecitabine-induced subacute cutaneous lupus erythematosus: Report of a case with positive rechallenge test. ( 24111883 )
2013
47
Subacute cutaneous lupus erythematosus induced by chemotherapy: gemcitabine as a causative agent. ( 23842655 )
2013
48
Annular subacute cutaneous lupus erythematosus lesions and polymyositis onset in a patient with primary Sjogren's syndrome: how should this unusual association be classified? ( 23358869 )
2013
49
Drug-induced subacute cutaneous lupus erythematosus--filling the gap in knowledge: comment on "subacute cutaneous lupus erythematosus induced by chemotherapy". ( 23842706 )
2013
50
Subacute cutaneous lupus erythematosus induced and exacerbated by proton pump inhibitors. ( 23548825 )
2013

Variations for Subacute Cutaneous Lupus Erythematosus

Expression for Subacute Cutaneous Lupus Erythematosus

Search GEO for disease gene expression data for Subacute Cutaneous Lupus Erythematosus.

Pathways for Subacute Cutaneous Lupus Erythematosus

Pathways related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.84 MBD1 TNF

GO Terms for Subacute Cutaneous Lupus Erythematosus

Cellular components related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 recycling endosome GO:0055037 8.62 EEA1 TNF

Biological processes related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 8.62 TNF TRIM21

Molecular functions related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 8.92 ACE EEA1 MBD1 TRIM21

Sources for Subacute Cutaneous Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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