MCID: SBC035
MIFTS: 42

Subacute Cutaneous Lupus Erythematosus malady

Skin category

Summaries for Subacute Cutaneous Lupus Erythematosus

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Subacute cutaneous lupus erythematosus (SCLE) is a clinically distinct subset of cases of lupus... more...

MalaCards: Subacute Cutaneous Lupus Erythematosus, also known as lupus erythematosus, subacute cutaneous, is related to systemic lupus erythematosus and arthritis. An important gene associated with Subacute Cutaneous Lupus Erythematosus is C1QA (complement component 1, q subcomponent, A chain), and among its related pathways are Tuberculosis and Apoptosis Modulation and Signaling. The compounds alefacept and efalizumab have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and breast, and related mouse phenotypes are mortality/aging and hematopoietic system.

Aliases & Classifications for Subacute Cutaneous Lupus Erythematosus

Sources:
49Orphanet, 61UMLS, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

subacute cutaneous lupus erythematosus 49
lupus erythematosus, subacute cutaneous 61


External Ids:

ICD10 via Orphanet26 L93.1
SNOMED-CT via Orphanet58 239891002
UMLS via Orphanet62 C0024140
ICD1025 L93.1

Related Diseases for Subacute Cutaneous Lupus Erythematosus

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the cutaneous lupus erythematosus family:

subacute cutaneous lupus erythematosus

Diseases related to Subacute Cutaneous Lupus Erythematosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus31.1CD70, TYK2, TRIM21, CTLA4, APOH, IRF5
2arthritis30.9TNF, CTLA4
3vasculitis30.8IFNA2, TNF, APOH, CTLA4, TRIM21
4lichen planus30.6IFNA2
5urticaria30.6ACE
6mixed connective tissue disease30.4APOH
7crohn's disease30.4TNF
8polymyositis30.4CTLA4
9sjogren's syndrome30.4APOH, TRIM21
10hepatitis c30.4CTLA4, TNF, IFNA1, IFNA2
11cutaneous lupus erythematosus11.5
12drug-induced lupus erythematosus10.9
13discoid lupus erythematosus10.8
14porphyria cutanea tarda10.6
15cutaneous porphyria10.6
16erythema multiforme10.4
17tinea corporis10.4
18kikuchi disease10.4
19toxic epidermal necrolysis10.4
20squamous cell papilloma10.3
21acute pancreatitis10.3
22molluscum contagiosum10.3
23hereditary angioedema10.3
24epidermolysis bullosa acquisita10.3
25keratoconjunctivitis sicca10.3
26hepatitis e10.3
27inclusion body myositis10.3
28skin meningioma10.3
29pityriasis rubra pilaris10.3
30herpes zoster10.3
31hepatitis a10.3
32adenocarcinoma10.3
33angioedema10.3
34squamous cell carcinoma10.3
35complement component deficiency10.3
36cutaneous malignant melanoma10.3
37chilblain lupus10.3
38lichen planus pemphigoides10.3
39lupus erythematosus panniculitis10.3
40myocarditis10.0PRF1
41hemophagocytic lymphohistiocytosis10.0PRF1
42meningitis10.0PRF1
43retinal vasculitis10.0APOH
44lupus nephritis10.0APOH
45endocarditis10.0PRF1
46retinal artery occlusion10.0APOH
47migraine10.0APOH
48polyneuropathy10.0IFNA2
49panuveitis10.0IFNA2
50polyarteritis nodosa10.0IFNA2

Graphical network of the top 20 diseases related to Subacute Cutaneous Lupus Erythematosus:



Diseases related to subacute cutaneous lupus erythematosus

Clinical Features for Subacute Cutaneous Lupus Erythematosus

Drugs & Therapeutics for Subacute Cutaneous Lupus Erythematosus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Subacute Cutaneous Lupus Erythematosus

Drug clinical trials:

Search ClinicalTrials for Subacute Cutaneous Lupus Erythematosus

Search NIH Clinical Center for Subacute Cutaneous Lupus Erythematosus

Search CenterWatch for Subacute Cutaneous Lupus Erythematosus

Genetic Tests for Subacute Cutaneous Lupus Erythematosus

Anatomical Context for Subacute Cutaneous Lupus Erythematosus

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Subacute Cutaneous Lupus Erythematosus:

33
Brain, Lung, Breast, Skin, Prostate, T cells, B cells

Animal Models for Subacute Cutaneous Lupus Erythematosus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Subacute Cutaneous Lupus Erythematosus:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.0MBD3, MBD4, TNF, APOH, CTLA4, PRF1
2MP:00053976.8TNF, IRF5, CTLA4, PRF1, TRIM21, TYK2
3MP:00053766.7IRF5, TNF, MBD4, MBD3, APOH, CTLA4
4MP:00053846.7ACE, C1QA, MBD3, MBD4, MBD1, TNF
5MP:00053876.6IRF5, TNF, MBD3, C1QA, CTLA4, PRF1

Publications for Subacute Cutaneous Lupus Erythematosus

Sources:
51PubMed
See all sources

Articles related to Subacute Cutaneous Lupus Erythematosus:

(show top 50)    (show all 268)
idTitleAuthorsYear
1
Annular subacute cutaneous lupus erythematosus lesions and polymyositis onset in a patient with primary Sjogren's syndrome: how should this unusual association be classified? (23358869)
2013
2
Subacute cutaneous lupus erythematosus in the course of rheumatoid arthritis: a relationship with TNF-I+ antagonists and rituximab therapy? (23537059)
2013
3
Subacute cutaneous lupus erythematosus due to proton pump inhibitor intake: case report and literature review. (23056090)
2012
4
A difficult diagnosis: drug-induced subacute cutaneous lupus erythematosus (SCLE) triggered by omeprazole in a patient with pre-existing idiopathic SCLE. (22420369)
2012
5
Drug-induced subacute cutaneous lupus erythematosus associated with doxorubicin. (23158635)
2012
6
Treatment of refractory subacute cutaneous lupus erythematosus with oral isotretinoin: a valid therapeutic option. (22913448)
2012
7
Golimumab-exacerbated subacute cutaneous lupus erythematosus. (23069957)
2012
8
Subacute-cutaneous lupus erythematosus induced by Simvastatin. (21040470)
2011
9
A systematic review of drug-induced subacute cutaneous lupus erythematosus. (21039412)
2011
10
Variable presentations of subacute cutaneous lupus erythematosus. (20642992)
2010
11
Omeprazole-induced subacute cutaneous lupus erythematosus. (20500156)
2010
12
Comparative analysis of subacute cutaneous lupus erythematosus and chronic cutaneous lupus erythematosus: clinical and immunological study of 270 patients. (19785596)
2010
13
Subacute cutaneous lupus erythematosus presenting as poikiloderma. (20055848)
2009
14
Lansoprazole-induced subacute cutaneous lupus erythematosus. (19508577)
2009
15
Subacute cutaneous lupus erythematosus after a tattoo. (19236415)
2009
16
Subacute cutaneous lupus erythematosus induced by capecitabine. (19456774)
2009
17
Leflunomide-induced subacute cutaneous lupus erythematosus with erythema multiforme-like lesions. (18413415)
2008
18
Incidental cases of subacute cutaneous lupus erythematosus in association with malignancy. (18955207)
2008
19
Tinea corporis masquerading as subacute cutaneous lupus erythematosus. (18627730)
2008
20
Pathogenesis of subacute cutaneous lupus erythematosus. (18540991)
2008
21
Dermacase. Cutaneous lupus erythematosus (subacute). (17879425)
2007
22
Subacute cutaneous lupus erythematosus presenting as erythroderma. (17459074)
2007
23
Bupropion-induced subacute cutaneous lupus erythematosus. (16197429)
2005
24
ITP as an initial manifestation of subacute cutaneous lupus erythematosus. (16361716)
2005
25
Bullous subacute cutaneous lupus erythematosus. (15115507)
2004
26
Papulonodular mucinosis associated with subacute cutaneous lupus erythematosus. (12771474)
2003
27
Homozygous single nucleotide polymorphism of the complement C1QA gene is associated with decreased levels of C1q in patients with subacute cutaneous lupus erythematosus. (12630757)
2003
28
Methotrexate treatment for refractory subacute cutaneous lupus erythematosus. (11907517)
2002
29
Autoinvolutive photoexacerbated tinea corporis mimicking a subacute cutaneous lupus erythematosus. (11501656)
2001
30
Cutaneous paraneoplastic syndrome as an immunologic phenomenon exemplified by paraneoplastic subacute cutaneous lupus erythematosus]. (10584550)
1999
31
Paraneoplastic subacute cutaneous lupus erythematosus: report of a case associated with cancer of the lung. (9094469)
1997
32
Widespread pruritic plaques in a patient with subacute cutaneous lupus erythematosus and hypocomplementemia: response to dapsone therapy. (8698914)
1996
33
Rare vascular changes in the brain in a case of subacute cutaneous lupus erythematosus. (8673432)
1995
34
Immunohistochemical analysis of chronic discoid and subacute cutaneous lupus erythematosus--relation to immunopathological mechanisms. (7756149)
1995
35
Coexistence of subacute cutaneous lupus erythematosus and porphyria cutanea tarda: a case report. (8536489)
1995
36
Clinical relevance of antibodies to Ro/SS-A and La/SS-B in subacute cutaneous lupus erythematosus and related conditions. (8509157)
1993
37
Human papillomavirus type 11 in multiple squamous cell carcinomas in a patient with subacute cutaneous lupus erythematosus. (1319432)
1992
38
Subacute cutaneous lupus erythematosus-like gyrate erythema and hypertrichosis lanuginosa acquisita associated with uterine adenocarcinoma. (1419767)
1992
39
Annular erythema. A comparative study of SjAPgren syndrome with subacute cutaneous lupus erythematosus. (1938076)
1991
40
Subacute cutaneous lupus erythematosus in Greece. A clinical, serological and genetic study. (2256585)
1990
41
Subacute cutaneous lupus erythematosus response to isotretinoin. (2242950)
1990
42
Dapsone is an effective therapy for the skin lesions of subacute cutaneous lupus erythematosus and urticarial vasculitis in a patient with C2 deficiency. (2290166)
1990
43
Pattern of cutaneous immunoglobulin G deposition in subacute cutaneous lupus erythematosus is reproduced by infusing purified anti-Ro (SSA) autoantibodies into human skin-grafted mice. (2651477)
1989
44
Interferon alfa therapy in severe unresponsive subacute cutaneous lupus erythematosus. (2811978)
1989
45
Subacute cutaneous lupus erythematosus. Genetic markers and clinical and immunological findings in patients. (2658845)
1989
46
Subacute cutaneous lupus-erythematosus in childhood. (2612123)
1989
47
Subacute cutaneous lupus erythematosus-like drug eruption due to combination diuretic hydrochlorothiazide and triamterene. (3346407)
1988
48
Subacute cutaneous lupus erythematosus in multiple members of a family with C2 deficiency. (3467658)
1987
49
Questions pertaining to the true frequencies with which anti-Ro/SS-A autoantibody and the HLA-DR3 phenotype occur in subacute cutaneous lupus erythematosus patients. (3492520)
1987
50
Subacute cutaneous lupus erythematosus: a cutaneous marker for a distinct lupus erythematosus subset. (533284)
1979

Genetic Variations for Subacute Cutaneous Lupus Erythematosus

Expression for genes affiliated with Subacute Cutaneous Lupus Erythematosus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Subacute Cutaneous Lupus Erythematosus

Search GEO for disease gene expression data for Subacute Cutaneous Lupus Erythematosus.

Pathways for genes affiliated with Subacute Cutaneous Lupus Erythematosus

Sources:
30KEGG, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 52QIAGEN
See all sources

Pathways related to Subacute Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7EEA1, TNF
2
Hide members
9.4PRF1, IRF5, TNF
3
Immune response IFN alpha/beta signaling pathway
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9.2TYK2, IRF5, IFNA2
4
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9.0TRIM21, IFNA1, IFNA2
58.9TNF, IFNA1, IFNA2
6
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8.9IFNA2, IFNA1, TNF
78.8IFNA2, IFNA1, TYK2
8
Hide members
8.7IFNA2, IFNA1, TNF, PRF1
9
Hide members
8.6IFNA1, TYK2, CD70
10
Hide members
8.4TYK2, TNF, IFNA1, IFNA2
118.4IFNA2, IFNA1, TNF, TYK2
12
Hide members
8.3TYK2, IRF5, IFNA1, IFNA2
13
Hide members
8.0IFNA2, IFNA1, TNF, CTLA4, PRF1
14
Hide members
7.8ACE, IRF5, TNF, IFNA1, IFNA2, C1QA
15
Hide members
7.2C1QA, IFNA2, IFNA1, IRF5, CTLA4, TRIM21

Compounds for genes affiliated with Subacute Cutaneous Lupus Erythematosus

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Subacute Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1alefacept45 1111.1C1QA, TNF
2efalizumab45 1111.0C1QA, TNF
3hydroxychloroquine45 1110.8APOH, TNF, IFNA2
4abatacept45 1110.8CTLA4, TNF
5procainamide45 1110.8APOH, CD70
6natalizumab45 1110.7C1QA, TNF
7pegasys459.7IFNA1, IFNA2
8entecavir459.7IFNA2, IFNA1
9mizoribine459.7IFNA2, IFNA1
10famciclovir45 1110.7IFNA2, IFNA1
11intron a459.7IFNA2, IFNA1
12n-phosphonacetyl-l-aspartate459.7IFNA2, IFNA1
13anagrelide45 1110.6IFNA2, IFNA1
14atpo45 2910.6IFNA1, APOH
15pentostatin45 60 29 1112.6IFNA2, IFNA1
16lomustine45 1110.6IFNA2, IFNA1
17etanercept45 50 1111.6C1QA, IFNA2, TNF, APOH
18rantes459.6IFNA1, TNF
195-deoxy-5-fluorouridine459.6IFNA2, IFNA1
20adefovir459.6IFNA1, IFNA2
21amantadine45 1110.5IFNA2, IFNA1
22didanosine45 1110.3IFNA1, IFNA2
23acitretin45 1110.3IFNA1, IFNA2
24imiquimod45 29 60 1112.3TNF, IFNA1, IFNA2
252,5-oligoadenylate459.3TNF, IFNA1, IFNA2
26melphalan45 1110.2TNF, IFNA1, IFNA2
27neopterin459.2IFNA2, IFNA1, TNF
28chloroquine45 2 50 29 1113.2IFNA1, TNF, EEA1
29infliximab45 50 1111.2IFNA2, TNF, APOH, CTLA4
30ifn-alpha459.1TYK2, IFNA1, IFNA2
31glatiramer acetate45 1110.1CTLA4, IFNA1
32busulfan45 1110.0IFNA1, IFNA2
33zinc45 2410.0IFNA2, MBD4, APOH, TRIM21, ACE, EEA1
34prednisolone45 29 1111.0IFNA2, IFNA1, TNF, APOH
35cholesterol45 29 11 2411.9EEA1, ACE, PRF1, CTLA4, APOH
36thalidomide45 50 60 1111.7IFNA2, IFNA1, TNF, CTLA4
37lipid458.3EEA1, ACE, CTLA4, APOH, TNF, IFNA2
38vegf458.3APOH, IRF5, TNF, IFNA1, IFNA2
39rituximab45 50 1110.2CTLA4, APOH, TNF, IFNA1, IFNA2, C1QA

GO Terms for genes affiliated with Subacute Cutaneous Lupus Erythematosus

Sources:
16Gene Ontology
See all sources

Biological processes related to Subacute Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:0516079.4PRF1, IRF5, IFNA2
2type I interferon-mediated signaling pathwayGO:0603378.9TYK2, IRF5, IFNA2

Molecular functions related to Subacute Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055155.1EEA1, IFNA2, MBD3, MBD4, MBD1, TNF

Products for genes affiliated with Subacute Cutaneous Lupus Erythematosus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Subacute Cutaneous Lupus Erythematosus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet