MCID: SBC035
MIFTS: 51

Subacute Cutaneous Lupus Erythematosus malady

Skin diseases, Rare diseases, Immune diseases categories

Summaries for Subacute Cutaneous Lupus Erythematosus

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66Wikipedia, 34MalaCards
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Wikipedia:66 Subacute cutaneous lupus erythematosus (SCLE) is a clinically distinct subset of cases of lupus... more...

MalaCards: Subacute Cutaneous Lupus Erythematosus, also known as lupus erythematosus, subacute cutaneous, is related to lupus erythematosus and systemic lupus erythematosus. An important gene associated with Subacute Cutaneous Lupus Erythematosus is C1QA (complement component 1, q subcomponent, A chain), and among its related pathways are Immune response IL 12 signaling pathway and Regulation of autophagy. The compounds pegasys and alefacept have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and lung, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Subacute Cutaneous Lupus Erythematosus

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Sources:
50Orphanet, 63UMLS, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases, Immune diseases
Orphanet: 50 
Rare skin diseases


Aliases & Descriptions:

subacute cutaneous lupus erythematosus 50
lupus erythematosus, subacute cutaneous 63


External Ids:

ICD10 via Orphanet27 L93.1
SNOMED-CT via Orphanet60 239891002
UMLS via Orphanet64 C0024140
ICD1026 L93.1

Related Diseases for Subacute Cutaneous Lupus Erythematosus

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Cutaneous Lupus Erythematosus family:

subacute cutaneous lupus erythematosus

Diseases related to Subacute Cutaneous Lupus Erythematosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus32.4APOH, IFNA2
2systemic lupus erythematosus31.3IRF5
3rheumatoid arthritis30.8TYK2, TNF, APOH, IRF5, CD70, CTLA4
4vasculitis30.8TNF, APOH, IFNA2, CTLA4, TRIM21
5skin disease30.5IFNA1, PRF1
6hepatitis b30.4IFNA1, IFNA2, CTLA4
7hepatitis30.4CTLA4, IFNA2, IFNA1
8connective tissue disease30.3TNF, APOH, IFNA1, CTLA4, TRIM21
9hepatocellular carcinoma30.3CTLA4, MBD4, IFNA2, IFNA1
10melanoma30.2TNF, PRF1, IFNA1, IFNA2, CD70, CTLA4
11cutaneous lupus erythematosus11.5
12arthritis10.6
13porphyria cutanea tarda10.6
14porphyria10.6
15psoriasis10.5
16discoid lupus erythematosus10.5
17lichen planus10.4
18erythema multiforme10.4
19myositis10.4
20tinea corporis10.4
21toxic epidermal necrolysis10.4
22crohn's disease10.3
23molluscum contagiosum10.3
24acute pancreatitis10.3
25pityriasis rubra pilaris10.3
26herpes zoster10.3
27hereditary angioedema10.3
28epidermolysis bullosa acquisita10.3
29keratoconjunctivitis sicca10.3
30sjogren's syndrome10.3
31mixed connective tissue disease10.3
32inclusion body myositis10.3
33adenocarcinoma10.3
34angioedema10.3
35dermatitis10.3
36eosinophilia10.3
37epidermolysis bullosa10.3
38hypertrichosis10.3
39keratoconjunctivitis10.3
40lymphadenitis10.3
41meningioma10.3
42pancreatitis10.3
43panniculitis10.3
44prostatitis10.3
45renal cell carcinoma10.3
46polymyositis10.3
47paraneoplastic syndromes10.3
48chilblain lupus10.3
49lichen planus pemphigoides10.3
50neonatal lupus erythematosus10.3

Graphical network of the top 20 diseases related to Subacute Cutaneous Lupus Erythematosus:



Diseases related to subacute cutaneous lupus erythematosus

Symptoms for Subacute Cutaneous Lupus Erythematosus

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Drugs & Therapeutics for Subacute Cutaneous Lupus Erythematosus

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Subacute Cutaneous Lupus Erythematosus

Drug clinical trials:

Search ClinicalTrials for Subacute Cutaneous Lupus Erythematosus

Search NIH Clinical Center for Subacute Cutaneous Lupus Erythematosus

Search CenterWatch for Subacute Cutaneous Lupus Erythematosus

Genetic Tests for Subacute Cutaneous Lupus Erythematosus

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Anatomical Context for Subacute Cutaneous Lupus Erythematosus

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34MalaCards
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MalaCards organs/tissues related to Subacute Cutaneous Lupus Erythematosus:

34
Skin, T cells, Lung, Breast, Brain, Testes, Prostate

Animal Models for Subacute Cutaneous Lupus Erythematosus or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Subacute Cutaneous Lupus Erythematosus:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5MBD4, MBD3, ACE, PRF1, TNF
2MP:00053847.4C1QA, TYK2, TNF, PRF1, ACE, MBD3
3MP:00053766.8TYK2, TNF, APOH, IRF5, PRF1, ACE
4MP:00107686.8APOH, TNF, TYK2, C1QA, PRF1, ACE
5MP:00053976.7TYK2, TNF, IRF5, PRF1, ACE, CD70
6MP:00053876.4TRIM21, C1QA, TYK2, TNF, IRF5, PRF1

Publications for Subacute Cutaneous Lupus Erythematosus

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53PubMed
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Articles related to Subacute Cutaneous Lupus Erythematosus:

(show top 50)    (show all 265)
idTitleAuthorsYear
1
Annular subacute cutaneous lupus erythematosus lesions and polymyositis onset in a patient with primary Sjogren's syndrome: how should this unusual association be classified? (23358869)
2013
2
A case of subacute cutaneous lupus erythematosus in a patient with mixed connective tissue disease: successful treatment with plasmapheresis and rituximab. (23984162)
2013
3
A case of subacute cutaneous lupus erythematosus as a result of ranibizumab (Lucentis) treatment. (24212210)
2013
4
Subacute cutaneous lupus erythematosus after treatment with capecitabine. (22937906)
2013
5
Taxane associated subacute cutaneous lupus erythematosus. (24021438)
2013
6
Toxic epidermal necrolysis-like subacute cutaneous lupus erythematosus. (23157783)
2012
7
Subacute Cutaneous Lupus Erythematosus Presenting in Childhood: A Case Report and Review of the Literature. (23106790)
2012
8
Atypical subacute cutaneous lupus erythematosus presenting as lichen planus pemphigoides with autoantibodies to C-terminus of BP180, desmoglein 1 and SS-A/Ro antigen. (22413755)
2012
9
Consider drugs as a cause or an exacerbating factor in patients diagnosed with subacute cutaneous lupus erythematosus! (22835019)
2012
10
Subacute cutaneous lupus erythematosus due to proton pump inhibitor intake: case report and literature review. (23056090)
2012
11
The interferon-regulated gene signature is elevated in subacute cutaneous lupus erythematosus and discoid lupus erythematosus and correlates with the cutaneous lupus area and severity index score. (22242767)
2012
12
Variable presentations of subacute cutaneous lupus erythematosus. (20642992)
2010
13
Subacute cutaneous lupus erythematosus associated with capecitabine monotherapy. (19289781)
2009
14
Terbinafine-induced subacute cutaneous lupus erythematosus. (18441768)
2008
15
Subacute cutaneous lupus erythematosus and interstitial myositis occurring with hepatitis B infection: response to antiviral therapy with lamivudine. (18664991)
2008
16
Occurrence of subacute cutaneous lupus erythematosus after treatment with fluorouracil and capecitabine. (18625380)
2008
17
Subacute cutaneous lupus erythematosus with bullae associated with porphyria cutanea tarda. (17338797)
2007
18
Subacute cutaneous lupus erythematosus on the lines of Blaschko. (16709500)
2006
19
Subacute cutaneous lupus erythematosus: 25-year evolution of a prototypic subset (subphenotype) of lupus erythematosus defined by characteristic cutaneous, pathological, immunological, and genetic findings. (15990071)
2005
20
Bupropion-induced subacute cutaneous lupus erythematosus. (16197429)
2005
21
Kikuchi's disease (necrotizing lymphadenitis) with cutaneous involvement associated with subacute cutaneous lupus erythematosus. (15115501)
2004
22
Bullous subacute cutaneous lupus erythematosus. (15115507)
2004
23
Successful treatment of subacute cutaneous lupus erythematosus with mycophenolate mofetil. (12100205)
2002
24
Frequency and severity of systemic disease in patients with subacute cutaneous lupus erythematosus. (12224978)
2002
25
Subacute cutaneous lupus erythematosus associated with hepatocellular carcinoma. (11309033)
2001
26
Erythema multiforme-like subacute cutaneous lupus erythematosus: a new variety? (11028873)
2000
27
Subacute cutaneous lupus erythematosus presenting with generalized poikiloderma. (10642688)
2000
28
The cutaneous pathology associated with seropositivity for antibodies to SSA (Ro): a clinicopathologic study of 23 adult patients without subacute cutaneous lupus erythematosus. (10218672)
1999
29
Lichenoid and subacute cutaneous lupus erythematosus-like dermatitis associated with antihistamine therapy. (10082400)
1999
30
Paraneoplastic subacute cutaneous lupus erythematosus: report of a case associated with cancer of the lung. (9094469)
1997
31
Rapid improvement of subacute cutaneous lupus erythematosus with low-dose methotrexate. (9187859)
1997
32
Leukocytoclastic vasculitis in subacute cutaneous lupus erythematosus: clinicopathologic study of three cases and review of the literature. (8944346)
1996
33
Childhood subacute cutaneous lupus erythematosus associated with homozygous complement 2 deficiency. (8747579)
1995
34
Subacute cutaneous lupus erythematosus associated with chronic interstitial pneumonitis. (7607798)
1995
35
Coexisting lichen planus and subacute cutaneous lupus erythematosus. (7671426)
1995
36
Pityriasis rubra pilaris presenting as subacute cutaneous lupus erythematosus. (8243104)
1993
37
A characteristic cutaneous direct immunofluorescent pattern associated with Ro(SS-A) antibodies in subacute cutaneous lupus erythematosus. (1430355)
1992
38
Figurate erythema, photosensitivity, and conjunctival irritation of recent onset. Subacute cutaneous lupus erythematosus (SCLE) and keratoconjunctivitis sicca. (1519943)
1992
39
Possible naproxen-induced relapse of subacute cutaneous lupus erythematosus. (1535107)
1992
40
Detection of anti-Ro(SSA) antibodies by gel double diffusion and a 'sandwich' ELISA in systemic and subacute cutaneous lupus erythematosus and SjAPgren's syndrome. (1903247)
1991
41
Response of discoid and subacute cutaneous lupus erythematosus to recombinant interferon alpha 2a. (2258631)
1990
42
IgG subclasses in the serum and skin in subacute cutaneous lupus erythematosus and neonatal lupus erythematosus. (2250107)
1990
43
Comparison of IgG subclass autoantibodies in patients with systemic lupus erythematosus and subacute cutaneous lupus erythematosus. (2085508)
1990
44
Subacute cutaneous lupus erythematosus in Greece. A clinical, serological and genetic study. (2256585)
1990
45
Pattern of cutaneous immunoglobulin G deposition in subacute cutaneous lupus erythematosus is reproduced by infusing purified anti-Ro (SSA) autoantibodies into human skin-grafted mice. (2651477)
1989
46
Subacute cutaneous lupus erythematosus presenting as erythroderma. (2970478)
1988
47
Subacute cutaneous lupus erythematosus. Clinical, serologic, immunogenetic, and therapeutic considerations in seventy-two patients. (3261587)
1988
48
A monoclonal Ro-antibody and the serum of a Ro-positive patient with subacute cutaneous lupus erythematosus (SCLE) react with basal layers of human epidermis. (3147897)
1988
49
Subacute cutaneous lupus erythematosus. (3880024)
1985
50
Relationships between antinuclear and anti-Ro/SS-A antibodies in subacute cutaneous lupus erythematosus. (6384294)
1984

Variations for Subacute Cutaneous Lupus Erythematosus

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Expression for genes affiliated with Subacute Cutaneous Lupus Erythematosus

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Subacute Cutaneous Lupus Erythematosus

Search GEO for disease gene expression data for Subacute Cutaneous Lupus Erythematosus.

Pathways for genes affiliated with Subacute Cutaneous Lupus Erythematosus

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Sources:
51PathCards, 61Thomson Reuters, 31KEGG, 54QIAGEN, 56Reactome, 39NCBI BioSystems Database, 55R&D Systems
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Pathways related to Subacute Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TYK2, PRF1
29.5IFNA2, IFNA1
39.5IFNA2, IFNA1
49.5TNF, TYK2
5
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
9.3PRF1, IRF5, TNF
6
Show member pathways
9.2IFNA1, IFNA2, TRIM21
7
Show member pathways
Type III interferon signaling39
9.2TYK2, IFNA1, IFNA2
89.2IFNA2, IFNA1, TYK2
9
Show member pathways
9.0TRIM21, MBD3, TNF, C1QA
10
Show member pathways
9.0TYK2, IRF5, IFNA1, IFNA2
11
Show member pathways
9.0TYK2, IRF5, IFNA1, IFNA2
12
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
8.9IFNA2, IFNA1, TNF
138.9IFNA2, IFNA1, TNF
14
Show member pathways
8.9IFNA2, IFNA1, TNF
158.9IFNA2, IFNA1, TNF
16
Show member pathways
Immune response CD16 signaling in NK cells61
8.6TNF, PRF1, IFNA1, IFNA2
178.6TYK2, TNF, IFNA1, IFNA2
18
Show member pathways
8.6TYK2, TNF, IFNA1, IFNA2
19
Show member pathways
8.6TYK2, TNF, IFNA1, IFNA2
20
Show member pathways
8.2CTLA4, IFNA2, IFNA1, PRF1, TNF
21
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
7.9ACE, IFNA2, IFNA1, IRF5, TNF, C1QA
22
Show member pathways
7.8CD70, IFNA2, IFNA1, TNF, TYK2

Compounds for genes affiliated with Subacute Cutaneous Lupus Erythematosus

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 52PharmGKB, 25HMDB
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Compounds related to Subacute Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1pegasys4610.0IFNA2, IFNA1
2alefacept46 1211.0TNF, C1QA
3entecavir4610.0IFNA2, IFNA1
4efalizumab46 1211.0TNF, C1QA
5famciclovir46 1210.9IFNA1, IFNA2
6n-phosphonacetyl-l-aspartate469.9IFNA1, IFNA2
7intron a469.9IFNA1, IFNA2
8atpo30 4610.9IFNA1, APOH
9mizoribine469.9IFNA1, IFNA2
10pentostatin46 62 30 1212.9IFNA1, IFNA2
11lomustine46 1210.9IFNA1, IFNA2
12anagrelide46 1210.9IFNA1, IFNA2
135-deoxy-5-fluorouridine469.9IFNA2, IFNA1
14natalizumab46 1210.9TNF, C1QA
15adefovir469.9IFNA1, IFNA2
16amantadine46 1210.9IFNA1, IFNA2
17didanosine46 52 1211.8IFNA2, IFNA1
18abatacept46 1210.8TNF, CTLA4
19acitretin46 1210.8IFNA2, IFNA1
20glatiramer acetate46 1210.8IFNA1, CTLA4
21busulfan46 52 1211.7IFNA1, IFNA2
22levamisole46 1210.7IFNA1, IFNA2
23dacarbazine46 1210.7IFNA1, IFNA2
24ifn-alpha469.6IFNA2, IFNA1, TYK2
25procainamide46 1210.6APOH, CD70
26hydroxychloroquine46 1210.5IFNA2, APOH, TNF
275-aza-2deoxycytidine469.5IFNA1, MBD1, MBD4
28acyclovir46 1210.4IFNA2, IFNA1
29cyclophosphamide46 52 1211.4APOH, IFNA1, IFNA2
30imiquimod46 62 30 1212.4TNF, IFNA1, IFNA2
312,5-oligoadenylate469.3IFNA2, IFNA1, TNF
32neopterin469.3TNF, IFNA1, IFNA2
33indoleamine469.3CTLA4, IFNA1, TNF
34mycophenolate mofetil46 52 1211.3TNF, IFNA1, CTLA4
35etanercept46 52 1211.3C1QA, TNF, APOH, IFNA2
36hydralazine46 52 1211.3ACE, CD70
37superoxide46 2510.1TNF, APOH, PRF1, IFNA2
38infliximab46 52 1211.1CTLA4, IFNA2, APOH, TNF
39il-12469.0IFNA1, TNF
40prednisolone46 30 1211.0TNF, APOH, IFNA1, IFNA2
41zinc46 2510.0APOH, IFNA2, ACE, MBD4, TRIM21
42prostacyclin469.0TNF, APOH, ACE
43melphalan46 52 1210.9TNF, IFNA1, IFNA2, CTLA4
44thalidomide46 52 62 1211.9TNF, IFNA1, IFNA2, CTLA4
45tacrolimus46 52 1210.9CTLA4, IFNA1, TNF
46ionomycin468.8TNF, CD70, CTLA4
47thymidine46 259.8CTLA4, IFNA2, IFNA1, TNF
48vegf468.7TNF, APOH, IRF5, IFNA1, IFNA2
49rantes468.5CTLA4, CD70, IFNA1, TNF
50rituximab46 52 1210.3CTLA4, IFNA2, IFNA1, APOH, TNF, C1QA

GO Terms for genes affiliated with Subacute Cutaneous Lupus Erythematosus

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17Gene Ontology
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Cellular components related to Subacute Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9CTLA4, ACE, TNF
2extracellular spaceGO:0056157.4CD70, ACE, IFNA2, APOH, TNF

Biological processes related to Subacute Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of type I interferon-mediated signaling pathwayGO:0603389.7IFNA2, TYK2
2type I interferon signaling pathwayGO:0603379.6IFNA2, IRF5, TYK2
3defense response to virusGO:0516079.6IFNA2, PRF1, IRF5
4cytokine-mediated signaling pathwayGO:0192219.4TYK2, IRF5, IFNA2
5extrinsic apoptotic signaling pathwayGO:0971919.0CD70, TNF
6cell-cell signalingGO:0072678.7CD70, IFNA2, C1QA

Molecular functions related to Subacute Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1methyl-CpG bindingGO:0083279.8MBD3, MBD1
2tumor necrosis factor receptor bindingGO:0051649.0CD70, TNF
3cytokine activityGO:0051258.3CD70, IFNA2, TNF
4protein bindingGO:0055155.0TRIM21, C1QA, TYK2, TNF, APOH, IRF5

Products for genes affiliated with Subacute Cutaneous Lupus Erythematosus

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  • Antibodies
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  • Antibodies

Sources for Subacute Cutaneous Lupus Erythematosus

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet