MCID: SBC035
MIFTS: 43

Subacute Cutaneous Lupus Erythematosus malady

Skin diseases, Rare diseases categories

Aliases & Classifications for Subacute Cutaneous Lupus Erythematosus

About this section
Sources:
48Orphanet, 61UMLS, 26ICD10 via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Aliases & Descriptions for Subacute Cutaneous Lupus Erythematosus:

Name: Subacute Cutaneous Lupus Erythematosus 48
 
Lupus Erythematosus, Subacute Cutaneous 61


Classifications:

Orphanet: 48 
Rare skin diseases


Characteristics (Orphanet epidemiological data):

48
subacute cutaneous lupus erythematosus:
Prevalence: 1-9/1000000 (United States)


External Ids:

Orphanet48 163525
ICD10 via Orphanet26 L93.1
UMLS via Orphanet62 C0024140
ICD1025 L93.1

Summaries for Subacute Cutaneous Lupus Erythematosus

About this section
Wikipedia:64 Subacute cutaneous lupus erythematosus (SCLE) is a clinically distinct subset of cases of lupus... more...

MalaCards based summary: Subacute Cutaneous Lupus Erythematosus, also known as lupus erythematosus, subacute cutaneous, is related to lupus erythematosus and systemic lupus erythematosus. An important gene associated with Subacute Cutaneous Lupus Erythematosus is C1QA (complement component 1, q subcomponent, A chain), and among its related pathways are Immune response IL 12 signaling pathway and Regulation of autophagy. The compounds pegasys and alefacept have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and lung, and related mouse phenotypes are tumorigenesis and cellular.

Related Diseases for Subacute Cutaneous Lupus Erythematosus

About this section

Diseases in the Cutaneous Lupus Erythematosus family:

subacute cutaneous lupus erythematosus

Diseases related to Subacute Cutaneous Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus32.7IFNA2, APOH
2systemic lupus erythematosus31.9IRF5
3skin disease30.7IFNA1, PRF1
4vasculitis30.4CTLA4, IFNA2, TNF, TRIM21, APOH
5hepatitis b30.3IFNA2, CTLA4, IFNA1
6rheumatoid arthritis30.2IRF5, TRIM21, CTLA4, APOH, TNF, TYK2
7hepatitis30.2CTLA4, IFNA2, IFNA1
8connective tissue disease29.8TNF, IFNA1, CTLA4, TRIM21, APOH
9hepatocellular carcinoma29.7IFNA2, IFNA1, MBD4, CTLA4
10melanoma29.6PRF1, IFNA1, IFNA2, TNF, CD70, CTLA4
11cutaneous lupus erythematosus11.5
12arthritis10.7
13porphyria cutanea tarda10.6
14porphyria10.6
15psoriasis10.6
16discoid lupus erythematosus10.6
17c1q deficiency10.5C1QA
18endophthalmitis10.5PRF1
19endocarditis10.5PRF1
20retinal vasculitis10.5APOH
21retinal artery occlusion10.5APOH
22c2 deficiency10.5
23lichen planus10.5
24erythema multiforme10.5
25myositis10.5
26tinea corporis10.5
27panuveitis10.5IFNA2
28degos disease10.5APOH
29polyarteritis nodosa10.5IFNA2
30lymphomatoid granulomatosis10.4IFNA2
31hemophagocytic lymphohistiocytosis10.4PRF1
32myocarditis10.4PRF1
33leprosy10.4MBD1
34stomatitis10.4IFNA2
35pityriasis rubra pilaris10.3
36chilblain lupus10.3
37renal cell carcinoma10.3
38cholangiocarcinoma10.3
39crohn's disease10.3
40molluscum contagiosum10.3
41acute pancreatitis10.3
42methemoglobinemia10.3
43herpes zoster10.3
44epidermolysis bullosa acquisita10.3
45keratoconjunctivitis sicca10.3
46sjogren's syndrome10.3
47mixed connective tissue disease10.3
48inclusion body myositis10.3
49adenocarcinoma10.3
50angioedema10.3

Graphical network of the top 20 diseases related to Subacute Cutaneous Lupus Erythematosus:



Diseases related to subacute cutaneous lupus erythematosus

Symptoms for Subacute Cutaneous Lupus Erythematosus

About this section

Drugs & Therapeutics for Subacute Cutaneous Lupus Erythematosus

About this section

Drug clinical trials:

Search ClinicalTrials for Subacute Cutaneous Lupus Erythematosus

Search NIH Clinical Center for Subacute Cutaneous Lupus Erythematosus

Genetic Tests for Subacute Cutaneous Lupus Erythematosus

About this section

Anatomical Context for Subacute Cutaneous Lupus Erythematosus

About this section

MalaCards organs/tissues related to Subacute Cutaneous Lupus Erythematosus:

31
Skin, T cells, Lung, Breast, Brain, Prostate, Testes

Animal Models for Subacute Cutaneous Lupus Erythematosus or affiliated genes

About this section

MGI Mouse Phenotypes related to Subacute Cutaneous Lupus Erythematosus:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5MBD4, MBD3, ACE, PRF1, TNF
2MP:00053847.4C1QA, TYK2, TNF, PRF1, ACE, MBD3
3MP:00053766.8TYK2, TNF, APOH, IRF5, PRF1, ACE
4MP:00107686.8APOH, TNF, TYK2, C1QA, PRF1, ACE
5MP:00053976.7TYK2, TNF, IRF5, PRF1, ACE, CD70
6MP:00053876.4TRIM21, C1QA, TYK2, TNF, IRF5, PRF1

Publications for Subacute Cutaneous Lupus Erythematosus

About this section

Articles related to Subacute Cutaneous Lupus Erythematosus:

(show top 50)    (show all 278)
idTitleAuthorsYear
1
Minocycline: a new molecule inducing subacute cutaneous lupus erythematosus? (25876148)
2015
2
Subacute cutaneous lupus erythematosus onset preceded by Kikuchi-Fujimoto disease. (24520513)
2014
3
An uncommon cutaneous reaction for a common drug. Diagnosis: Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE). (25244994)
2014
4
Annular subacute cutaneous lupus erythematosus lesions and polymyositis onset in a patient with primary Sjogren's syndrome: how should this unusual association be classified? (23358869)
2013
5
A case of subacute cutaneous lupus erythematosus in a patient with mixed connective tissue disease: successful treatment with plasmapheresis and rituximab. (23984162)
2013
6
A case of subacute cutaneous lupus erythematosus as a result of ranibizumab (Lucentis) treatment. (24212210)
2013
7
Subacute cutaneous lupus erythematosus after treatment with capecitabine. (22937906)
2013
8
Toxic epidermal necrolysis-like subacute cutaneous lupus erythematosus. (23157783)
2012
9
Subacute Cutaneous Lupus Erythematosus Presenting in Childhood: A Case Report and Review of the Literature. (23106790)
2012
10
Atypical subacute cutaneous lupus erythematosus presenting as lichen planus pemphigoides with autoantibodies to C-terminus of BP180, desmoglein 1 and SS-A/Ro antigen. (22413755)
2012
11
Consider drugs as a cause or an exacerbating factor in patients diagnosed with subacute cutaneous lupus erythematosus! (22835019)
2012
12
Subacute cutaneous lupus erythematosus due to proton pump inhibitor intake: case report and literature review. (23056090)
2012
13
Variable presentations of subacute cutaneous lupus erythematosus. (20642992)
2010
14
Subacute cutaneous lupus erythematosus associated with capecitabine monotherapy. (19289781)
2009
15
Terbinafine-induced subacute cutaneous lupus erythematosus. (18441768)
2008
16
Subacute cutaneous lupus erythematosus and interstitial myositis occurring with hepatitis B infection: response to antiviral therapy with lamivudine. (18664991)
2008
17
Occurrence of subacute cutaneous lupus erythematosus after treatment with fluorouracil and capecitabine. (18625380)
2008
18
Subacute cutaneous lupus erythematosus with bullae associated with porphyria cutanea tarda. (17338797)
2007
19
Subacute cutaneous lupus erythematosus on the lines of Blaschko. (16709500)
2006
20
Subacute cutaneous lupus erythematosus: 25-year evolution of a prototypic subset (subphenotype) of lupus erythematosus defined by characteristic cutaneous, pathological, immunological, and genetic findings. (15990071)
2005
21
Bupropion-induced subacute cutaneous lupus erythematosus. (16197429)
2005
22
Kikuchi's disease (necrotizing lymphadenitis) with cutaneous involvement associated with subacute cutaneous lupus erythematosus. (15115501)
2004
23
Bullous subacute cutaneous lupus erythematosus. (15115507)
2004
24
Successful treatment of subacute cutaneous lupus erythematosus with mycophenolate mofetil. (12100205)
2002
25
Frequency and severity of systemic disease in patients with subacute cutaneous lupus erythematosus. (12224978)
2002
26
Subacute cutaneous lupus erythematosus associated with hepatocellular carcinoma. (11309033)
2001
27
Erythema multiforme-like subacute cutaneous lupus erythematosus: a new variety? (11028873)
2000
28
Subacute cutaneous lupus erythematosus presenting with generalized poikiloderma. (10642688)
2000
29
The cutaneous pathology associated with seropositivity for antibodies to SSA (Ro): a clinicopathologic study of 23 adult patients without subacute cutaneous lupus erythematosus. (10218672)
1999
30
Lichenoid and subacute cutaneous lupus erythematosus-like dermatitis associated with antihistamine therapy. (10082400)
1999
31
Paraneoplastic subacute cutaneous lupus erythematosus: report of a case associated with cancer of the lung. (9094469)
1997
32
Rapid improvement of subacute cutaneous lupus erythematosus with low-dose methotrexate. (9187859)
1997
33
Leukocytoclastic vasculitis in subacute cutaneous lupus erythematosus: clinicopathologic study of three cases and review of the literature. (8944346)
1996
34
Childhood subacute cutaneous lupus erythematosus associated with homozygous complement 2 deficiency. (8747579)
1995
35
Subacute cutaneous lupus erythematosus associated with chronic interstitial pneumonitis. (7607798)
1995
36
Coexisting lichen planus and subacute cutaneous lupus erythematosus. (7671426)
1995
37
Pityriasis rubra pilaris presenting as subacute cutaneous lupus erythematosus. (8243104)
1993
38
A characteristic cutaneous direct immunofluorescent pattern associated with Ro(SS-A) antibodies in subacute cutaneous lupus erythematosus. (1430355)
1992
39
Figurate erythema, photosensitivity, and conjunctival irritation of recent onset. Subacute cutaneous lupus erythematosus (SCLE) and keratoconjunctivitis sicca. (1519943)
1992
40
Possible naproxen-induced relapse of subacute cutaneous lupus erythematosus. (1535107)
1992
41
Detection of anti-Ro(SSA) antibodies by gel double diffusion and a 'sandwich' ELISA in systemic and subacute cutaneous lupus erythematosus and SjAPgren's syndrome. (1903247)
1991
42
Response of discoid and subacute cutaneous lupus erythematosus to recombinant interferon alpha 2a. (2258631)
1990
43
IgG subclasses in the serum and skin in subacute cutaneous lupus erythematosus and neonatal lupus erythematosus. (2250107)
1990
44
Comparison of IgG subclass autoantibodies in patients with systemic lupus erythematosus and subacute cutaneous lupus erythematosus. (2085508)
1990
45
Subacute cutaneous lupus erythematosus in Greece. A clinical, serological and genetic study. (2256585)
1990
46
Pattern of cutaneous immunoglobulin G deposition in subacute cutaneous lupus erythematosus is reproduced by infusing purified anti-Ro (SSA) autoantibodies into human skin-grafted mice. (2651477)
1989
47
Subacute cutaneous lupus erythematosus presenting as erythroderma. (2970478)
1988
48
Subacute cutaneous lupus erythematosus. Clinical, serologic, immunogenetic, and therapeutic considerations in seventy-two patients. (3261587)
1988
49
Relationships between antinuclear and anti-Ro/SS-A antibodies in subacute cutaneous lupus erythematosus. (6384294)
1984
50
Human histocompatibility antigen associations in subacute cutaneous lupus erythematosus. (7451656)
1981

Variations for Subacute Cutaneous Lupus Erythematosus

About this section

Expression for genes affiliated with Subacute Cutaneous Lupus Erythematosus

About this section
Search GEO for disease gene expression data for Subacute Cutaneous Lupus Erythematosus.

Pathways for genes affiliated with Subacute Cutaneous Lupus Erythematosus

About this section

Pathways related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TYK2, PRF1
29.5IFNA2, IFNA1
39.5IFNA2, IFNA1
49.5TNF, TYK2
5
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.3IRF5, PRF1, TNF
6
Show member pathways
9.2IFNA2, IFNA1, TRIM21
79.2TYK2, IFNA2, IFNA1
8
Show member pathways
Type III interferon signaling36
9.2TYK2, IFNA1, IFNA2
9
Show member pathways
9.0MBD3, C1QA, TNF, TRIM21
10
Show member pathways
9.0IFNA2, IFNA1, IRF5, TYK2
11
Show member pathways
9.0TYK2, IRF5, IFNA1, IFNA2
12
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
8.9IFNA2, IFNA1, TNF
138.9IFNA1, TNF, IFNA2
14
Show member pathways
8.9IFNA2, IFNA1, TNF
158.9TNF, IFNA1, IFNA2
16
Show member pathways
Immune response CD16 signaling in NK cells59
8.6IFNA1, TNF, PRF1, IFNA2
178.6TYK2, TNF, IFNA1, IFNA2
18
Show member pathways
8.6TYK2, TNF, IFNA1, IFNA2
19
Show member pathways
8.6IFNA2, IFNA1, TYK2, TNF
20
Show member pathways
8.2TNF, PRF1, IFNA1, CTLA4, IFNA2
21
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
7.9ACE, IFNA2, IFNA1, IRF5, TNF, C1QA
22
Show member pathways
7.8TYK2, CD70, IFNA2, IFNA1, TNF

Compounds for genes affiliated with Subacute Cutaneous Lupus Erythematosus

About this section

Compounds related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1pegasys4410.0IFNA2, IFNA1
2alefacept44 1111.0TNF, C1QA
3entecavir4410.0IFNA1, IFNA2
4efalizumab44 1111.0TNF, C1QA
5intron a449.9IFNA2, IFNA1
6famciclovir44 1110.9IFNA1, IFNA2
7atpo28 4410.9APOH, IFNA1
8mizoribine449.9IFNA2, IFNA1
9n-phosphonacetyl-l-aspartate449.9IFNA2, IFNA1
10anagrelide44 1110.9IFNA1, IFNA2
11lomustine44 1110.9IFNA2, IFNA1
12pentostatin44 60 28 1112.9IFNA1, IFNA2
13natalizumab44 1110.9TNF, C1QA
145-deoxy-5-fluorouridine449.9IFNA1, IFNA2
15adefovir449.9IFNA1, IFNA2
16amantadine44 1110.9IFNA2, IFNA1
17didanosine44 50 1111.8IFNA1, IFNA2
18abatacept44 1110.8CTLA4, TNF
19acitretin44 1110.8IFNA1, IFNA2
20glatiramer acetate44 1110.8IFNA1, CTLA4
21levamisole44 1110.8IFNA1, IFNA2
22busulfan44 50 1111.7IFNA1, IFNA2
23dacarbazine44 1110.6IFNA2, IFNA1
24ifn-alpha449.6TYK2, IFNA1, IFNA2
25procainamide44 1110.6APOH, CD70
265-aza-2deoxycytidine449.5MBD4, MBD1, IFNA1
27hydroxychloroquine44 1110.5IFNA2, APOH, TNF
28acyclovir44 1110.4IFNA1, IFNA2
29cyclophosphamide44 50 1111.4IFNA2, IFNA1, APOH
30imiquimod44 60 28 1112.4TNF, IFNA2, IFNA1
312,5-oligoadenylate449.3TNF, IFNA2, IFNA1
32hydralazine44 50 1111.3CD70, ACE
33neopterin449.3IFNA1, TNF, IFNA2
34indoleamine449.3IFNA1, CTLA4, TNF
35mycophenolate mofetil44 50 1111.3IFNA1, CTLA4, TNF
36etanercept44 50 1111.3C1QA, APOH, IFNA2, TNF
37superoxide44 2410.1TNF, IFNA2, PRF1, APOH
38infliximab44 50 1111.1TNF, IFNA2, APOH, CTLA4
39il-12449.0IFNA1, TNF
40prednisolone44 28 1111.0TNF, APOH, IFNA1, IFNA2
41zinc44 2410.0ACE, TRIM21, MBD4, IFNA2, APOH
42prostacyclin449.0ACE, TNF, APOH
43melphalan44 50 1110.9IFNA2, TNF, IFNA1, CTLA4
44thalidomide44 50 60 1111.9TNF, CTLA4, IFNA2, IFNA1
45tacrolimus44 50 1110.9IFNA1, TNF, CTLA4
46thymidine44 249.8IFNA2, IFNA1, CTLA4, TNF
47ionomycin448.8CTLA4, CD70, TNF
48vegf448.7APOH, IFNA2, IFNA1, IRF5, TNF
49rantes448.5CTLA4, CD70, IFNA1, TNF
50rituximab44 50 1110.3IFNA2, APOH, CTLA4, TNF, C1QA, IFNA1

GO Terms for genes affiliated with Subacute Cutaneous Lupus Erythematosus

About this section

Cellular components related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.9CTLA4, ACE, TNF
2extracellular spaceGO:00056157.4CD70, ACE, IFNA2, APOH, TNF

Biological processes related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of type I interferon-mediated signaling pathwayGO:00603389.7IFNA2, TYK2
2type I interferon signaling pathwayGO:00603379.6IFNA2, IRF5, TYK2
3defense response to virusGO:00516079.6IFNA2, PRF1, IRF5
4cytokine-mediated signaling pathwayGO:00192219.4TYK2, IRF5, IFNA2
5extrinsic apoptotic signaling pathwayGO:00971919.0CD70, TNF
6cell-cell signalingGO:00072678.7CD70, IFNA2, C1QA

Molecular functions related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1methyl-CpG bindingGO:00083279.8MBD3, MBD1
2tumor necrosis factor receptor bindingGO:00051649.0CD70, TNF
3cytokine activityGO:00051258.3CD70, IFNA2, TNF
4protein bindingGO:00055155.0TRIM21, C1QA, TYK2, TNF, APOH, IRF5

Sources for Subacute Cutaneous Lupus Erythematosus

About this section
2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet