MCID: SBC035
MIFTS: 37

Subacute Cutaneous Lupus Erythematosus

Categories: Skin diseases, Immune diseases, Rare diseases

Aliases & Classifications for Subacute Cutaneous Lupus Erythematosus

MalaCards integrated aliases for Subacute Cutaneous Lupus Erythematosus:

Name: Subacute Cutaneous Lupus Erythematosus 55
Lupus Erythematosus, Subacute Cutaneous 69
Lupus Erythematosus Cutaneous Subacute 51

Characteristics:

Orphanet epidemiological data:

55
subacute cutaneous lupus erythematosus
Prevalence: 1-9/1000000 (United States);

Classifications:

Orphanet: 55  
Rare skin diseases


External Ids:

Orphanet 55 ORPHA163525
UMLS via Orphanet 70 C0024140
ICD10 via Orphanet 33 L93.1
ICD10 32 L93.1
UMLS 69 C0024140

Summaries for Subacute Cutaneous Lupus Erythematosus

MalaCards based summary : Subacute Cutaneous Lupus Erythematosus, also known as lupus erythematosus, subacute cutaneous, is related to cutaneous lupus erythematosus and connective tissue disease. An important gene associated with Subacute Cutaneous Lupus Erythematosus is TRIM21 (Tripartite Motif Containing 21), and among its related pathways/superpathways is Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Alitretinoin and Tretinoin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and lung.

Wikipedia : 72 Subacute cutaneous lupus erythematosus (SCLE) is a clinically distinct subset of cases of lupus... more...

Related Diseases for Subacute Cutaneous Lupus Erythematosus

Diseases in the Cutaneous Lupus Erythematosus family:

Subacute Cutaneous Lupus Erythematosus

Diseases related to Subacute Cutaneous Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 cutaneous lupus erythematosus 31.2 EEA1 TNF TRIM21
2 connective tissue disease 28.8 ACE TNF
3 lupus erythematosus 11.1
4 systemic lupus erythematosus 10.3
5 arthritis 10.2
6 rheumatoid arthritis 10.2
7 vasculitis 10.2
8 psoriasis 10.2
9 porphyria cutanea tarda 10.2
10 porphyria 10.2
11 pustulosis of palm and sole 10.2
12 discoid lupus erythematosus 10.1
13 leprosy 3 10.1 MBD1 TNF
14 sialadenitis 10.0 TNF TRIM21
15 lacrimal apparatus disease 10.0 TNF TRIM21
16 exanthem 10.0 TNF TRIM21
17 cogan syndrome 10.0 TNF TRIM21
18 annular erythema 10.0
19 squamous cell carcinoma 10.0
20 neuropathy 10.0
21 hepatitis 10.0
22 myositis 10.0
23 lichen planus 10.0
24 erythema multiforme 10.0
25 adenocarcinoma 10.0
26 complement component 2 deficiency 10.0
27 tinea corporis 10.0
28 rheumatic disease 9.9 TNF TRIM21
29 skin sarcoidosis 9.9 ACE TNF
30 granulomatous dermatitis 9.9 ACE TNF
31 posterior urethral valves 9.9 ACE TNF
32 ischemic heart disease 9.9 ACE TNF
33 hypersensitivity reaction type iv disease 9.9 ACE TNF
34 extrinsic cardiomyopathy 9.9 ACE TNF
35 wegener granulomatosis 9.9
36 hereditary angioedema 9.9
37 pancreatitis 9.9
38 chilblain lupus 1 9.9
39 panniculitis 9.9
40 aspergillosis 9.9
41 angioedema 9.9
42 herpes zoster 9.9
43 blood group--diego system 9.9
44 cholangiocarcinoma 9.9
45 lymphadenitis 9.9
46 hepatocellular carcinoma 9.9
47 renal cell carcinoma, nonpapillary 9.9
48 crohn's disease 9.9
49 hepatitis c 9.9
50 inclusion body myositis 9.9

Graphical network of the top 20 diseases related to Subacute Cutaneous Lupus Erythematosus:



Diseases related to Subacute Cutaneous Lupus Erythematosus

Symptoms & Phenotypes for Subacute Cutaneous Lupus Erythematosus

Drugs & Therapeutics for Subacute Cutaneous Lupus Erythematosus

Drugs for Subacute Cutaneous Lupus Erythematosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alitretinoin Approved, Investigational Phase 2 5300-03-8 444795
2
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538
3 Dermatologic Agents Phase 2
4 Keratolytic Agents Phase 2
5
Tacrolimus Approved, Investigational 104987-11-3 445643 439492
6
Pimecrolimus Approved, Investigational 137071-32-0 17753757 6447131
7 Analgesics
8 Analgesics, Non-Narcotic
9 Peripheral Nervous System Agents
10 Immunosuppressive Agents
11 Anti-Inflammatory Agents
12 Anti-Inflammatory Agents, Non-Steroidal
13 Antirheumatic Agents
14 Calcineurin Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of KRP203 in Subacute Cutaneous Lupus Erythematosus Completed NCT01294774 Phase 2 KRP203 - 1.2mg;Placebo to KRP203 - 1.2 mg
2 To Evaluate the Preliminary Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of CC-11050 in Subjects With Discoid Lupus Erythematosus and Subacute Cutaneous Lupus Erythematosus Completed NCT01300208 Phase 2 CC-11050
3 Study to Evaluate BIIB059 in Cutaneous Lupus Erythematosus (CLE) With or Without Systemic Lupus Erythematosus (SLE) Recruiting NCT02847598 Phase 2 BIIB059;Placebo
4 Efficacy and Safety of Oral Alitretinoin (Toctino®) in the Treatment of Patients With Cutaneous Lupus Erythematosus Terminated NCT01407679 Phase 2 Alitretinoin
5 Safety Study of AMG 557 in Subjects With Subacute Cutaneous Lupus Erythematosus Terminated NCT01389895 Phase 1 AMG 557;AMG 557 Placebo
6 Cutaneous Lupus Erythematosus and Elidel Unknown status NCT00222183 Elidel (pimecrolimus)
7 Pilot Tape Harvesting Study Completed NCT02125695
8 A Non-drug Study Profiling Cutaneous Lupus Completed NCT01923415 Early Phase 1
9 A Study of Skin and Systemic Biomarkers In Patients With Active Cutaneous Lupus Erythematosus And In Healthy Volunteers Completed NCT02034344 Early Phase 1
10 The Human Microbiome in Immune-Mediated Diseases Recruiting NCT02394964

Search NIH Clinical Center for Subacute Cutaneous Lupus Erythematosus

Genetic Tests for Subacute Cutaneous Lupus Erythematosus

Anatomical Context for Subacute Cutaneous Lupus Erythematosus

MalaCards organs/tissues related to Subacute Cutaneous Lupus Erythematosus:

38
Skin, T Cells, Lung, Testes, Brain, Colon, Prostate

Publications for Subacute Cutaneous Lupus Erythematosus

Articles related to Subacute Cutaneous Lupus Erythematosus:

(show top 50) (show all 310)
# Title Authors Year
1
Subacute cutaneous lupus erythematosus presenting in twins. ( 29436018 )
2018
2
Subacute Cutaneous Lupus Erythematosus Induced by Palbociclib. ( 29307217 )
2018
3
Subacute cutaneous lupus erythematosus: is clopidogrel a trigger? ( 29327459 )
2018
4
Rowell's Syndrome or subacute cutaneous lupus erythematosus? ( 27978611 )
2017
5
Subacute cutaneous lupus erythematosus induced by nivolumab. ( 28726325 )
2017
6
Topical drug-induced subacute cutaneous lupus erythematosus isolated to the hands. ( 28331627 )
2017
7
An update in drug-induced subacute cutaneous lupus erythematosus. ( 28329511 )
2017
8
Subacute Cutaneous Lupus Erythematosus: Clinical Characteristics, Disease Associations, Treatments, and Outcomes in a Series of 90A Patients at Mayo Clinic, 1996-2011. ( 28185656 )
2017
9
Subacute cutaneous lupus erythematosus - paraneoplastic to gastric adenocarcinoma? ( 28421344 )
2017
10
Subacute cutaneous lupus erythematosus induced by masitinib. ( 28940367 )
2017
11
Voriconazole-Induced Subacute Cutaneous Lupus Erythematosus in an Adult With Aspergillosis. ( 28031137 )
2016
12
First case of paraneoplastic subacute cutaneous lupus erythematosus associated with colon cancer. ( 27836354 )
2016
13
Dermoscopy of subacute cutaneous lupus erythematosus. ( 27260752 )
2016
14
Proton Pump Inhibitor-Associated Subacute Cutaneous Lupus Erythematosus in a Patient With Granulomatosis With Polyangiitis. ( 27870768 )
2016
15
Drug-Induced Subacute Cutaneous Lupus Erythematosus Associated with Proton Pump Inhibitors. ( 27398293 )
2016
16
Rare Occurrence of Drug Induced Subacute Cutaneous Lupus Erythematosus with Leflunomide Therapy. ( 27891379 )
2016
17
Anastrozole-induced subacute cutaneous lupus erythematosus. ( 27622265 )
2016
18
Using the American College of Rheumatology (ACR) and Systemic Lupus International Collaborating Clinics (SLICC) criteria to determine the diagnosis of systemic lupus erythematosus (SLE) in patients with subacute cutaneous lupus erythematosus (SCLE). ( 26897388 )
2016
19
Subacute cutaneous lupus erythematosus. ( 27286780 )
2016
20
Lenalidomide for refractory chronic and subacute cutaneous lupus erythematosus: 16 patients. ( 27185425 )
2016
21
Gemcitabine-Induced Subacute Cutaneous Lupus Erythematosus: A Case Report. ( 26928175 )
2016
22
Subacute cutaneous lupus erythematosus inducing unilateral sensorimotor neuropathy. ( 27888319 )
2016
23
Subacute cutaneous lupus erythematosus induced by lansoprazole. ( 25855412 )
2015
24
Subacute Cutaneous Lupus Erythematosus Induced by Mitotane. ( 26444320 )
2015
25
Drug-Induced Subacute Cutaneous Lupus Erythematosus in a Patient Receiving Therapy for Chronic Hepatitis C. ( 26539906 )
2015
26
Subacute cutaneous lupus erythematosus starting as linear lupus erythematosus. ( 26235783 )
2015
27
Subacute cutaneous lupus erythematosus induced by capecitabine: 5-FU was innocent. ( 26551520 )
2015
28
Minocycline: a new molecule inducing subacute cutaneous lupus erythematosus? ( 25876148 )
2015
29
Imiquimod-induced subacute cutaneous lupus erythematosus-like changes. ( 26125212 )
2015
30
Docetaxel-induced-like subacute cutaneous lupus erythematosus. ( 26350359 )
2015
31
Patient with terbinafine-induced subacute cutaneous lupus erythematosus followed by thalidomide-induced orofacial neuropathy; Beta blocker use, hypertension, and the risk of psoriasis; eczematous reaction to intravenous immunoglobulin; nicolau syndrome after intra-articular glucocorticoid injection; troponin leak associated with drug-induced methemoglobinemia. ( 25684795 )
2015
32
Proton pump inhibitor-induced subacute cutaneous lupus erythematosus. ( 24547721 )
2014
33
Pediatric subacute cutaneous lupus erythematosus: report of three cases. ( 25209420 )
2014
34
Subacute cutaneous lupus erythematosus associated with pemetrexed plus Carboplatin chemotherapy. ( 25417687 )
2014
35
An uncommon cutaneous reaction for a common drug. Diagnosis: Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE). ( 25244994 )
2014
36
Proton pump inhibitors and subacute cutaneous lupus erythematosus: an under-recognized phenomenon? ( 24547716 )
2014
37
Paraneoplastic subacute cutaneous lupus erythematosus associated with cholangiocarcinoma. ( 25367767 )
2014
38
Subacute cutaneous lupus erythematosus: a paraneoplastic phenomenon in oropharyngeal squamous cell carcinoma. ( 25284285 )
2014
39
The concurrence of subacute cutaneous lupus erythematosus and hand-foot syndrome in a patient undergoing capecitabine chemotherapy. ( 25495707 )
2014
40
Subacute cutaneous lupus erythematosus presenting as erythroderma. ( 25484433 )
2014
41
Subacute cutaneous lupus erythematosus onset preceded by Kikuchi-Fujimoto disease. ( 24520513 )
2014
42
Drug-induced subacute cutaneous lupus erythematosus associated with docetaxel chemotherapy: a case report. ( 25369825 )
2014
43
What is your diagnosis? subacute cutaneous lupus erythematosus. ( 24818184 )
2014
44
Subacute cutaneous lupus erythematosus induced by the new multikinase inhibitor pazopanib. ( 24909204 )
2014
45
Drug-induced subacute cutaneous lupus erythematosus associated with nab-paclitaxel therapy. ( 24155645 )
2013
46
Subacute cutaneous lupus erythematosus in the course of rheumatoid arthritis: a relationship with TNF-I+ antagonists and rituximab therapy? ( 23537059 )
2013
47
Subacute cutaneous lupus erythematosus induced by chemotherapy: gemcitabine as a causative agent. ( 23842655 )
2013
48
Drug-induced subacute cutaneous lupus erythematosus--filling the gap in knowledge: comment on "subacute cutaneous lupus erythematosus induced by chemotherapy". ( 23842706 )
2013
49
Docetaxel-induced relapse of subacute cutaneous lupus erythematosus and chilblain lupus. ( 23848065 )
2013
50
Subacute cutaneous lupus erythematosus induced and exacerbated by proton pump inhibitors. ( 23548825 )
2013

Variations for Subacute Cutaneous Lupus Erythematosus

Expression for Subacute Cutaneous Lupus Erythematosus

Search GEO for disease gene expression data for Subacute Cutaneous Lupus Erythematosus.

Pathways for Subacute Cutaneous Lupus Erythematosus

Pathways related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.84 MBD1 TNF

GO Terms for Subacute Cutaneous Lupus Erythematosus

Cellular components related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 recycling endosome GO:0055037 8.62 EEA1 TNF

Biological processes related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA binding transcription factor activity GO:0051091 8.62 TNF TRIM21

Molecular functions related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 8.92 ACE EEA1 MBD1 TRIM21

Sources for Subacute Cutaneous Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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