MCID: SBC035
MIFTS: 43

Subacute Cutaneous Lupus Erythematosus malady

Skin diseases, Rare diseases categories

Summaries for Subacute Cutaneous Lupus Erythematosus

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Wikipedia:63 Subacute cutaneous lupus erythematosus (SCLE) is a clinically distinct subset of cases of lupus... more...

MalaCards based summary: Subacute Cutaneous Lupus Erythematosus, also known as lupus erythematosus, subacute cutaneous, is related to lupus erythematosus and systemic lupus erythematosus. An important gene associated with Subacute Cutaneous Lupus Erythematosus is C1QA (complement component 1, q subcomponent, A chain), and among its related pathways are Immune response IL 12 signaling pathway and Regulation of autophagy. The compounds pegasys and alefacept have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and lung, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Subacute Cutaneous Lupus Erythematosus

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Sources:
47Orphanet, 60UMLS, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Subacute Cutaneous Lupus Erythematosus, Aliases & Descriptions:

Name: Subacute Cutaneous Lupus Erythematosus 47
 
Lupus Erythematosus, Subacute Cutaneous 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases
Orphanet: 47 
Rare skin diseases


Characteristics (Orphanet epidemiological data):

47
subacute cutaneous lupus erythematosus:
Prevalence: 1-9/1000000 (United States)


External Ids:

Orphanet47 163525
ICD10 via Orphanet26 L93.1
UMLS via Orphanet61 C0024140
ICD1025 L93.1

Related Diseases for Subacute Cutaneous Lupus Erythematosus

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Diseases in the Cutaneous Lupus Erythematosus family:

subacute cutaneous lupus erythematosus

Diseases related to Subacute Cutaneous Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus32.7IFNA2, APOH
2systemic lupus erythematosus31.9IRF5
3skin disease30.7IFNA1, PRF1
4vasculitis30.4CTLA4, IFNA2, TNF, TRIM21, APOH
5hepatitis b30.3IFNA2, CTLA4, IFNA1
6rheumatoid arthritis30.2IRF5, TRIM21, CTLA4, APOH, TNF, TYK2
7hepatitis30.2CTLA4, IFNA2, IFNA1
8connective tissue disease29.8TNF, IFNA1, CTLA4, TRIM21, APOH
9hepatocellular carcinoma29.7IFNA2, IFNA1, MBD4, CTLA4
10melanoma29.6PRF1, IFNA1, IFNA2, TNF, CD70, CTLA4
11cutaneous lupus erythematosus11.5
12arthritis10.7
13porphyria cutanea tarda10.6
14porphyria10.6
15psoriasis10.6
16discoid lupus erythematosus10.6
17c1q deficiency10.5C1QA
18endophthalmitis10.5PRF1
19endocarditis10.5PRF1
20retinal vasculitis10.5APOH
21retinal artery occlusion10.5APOH
22c2 deficiency10.5
23lichen planus10.5
24erythema multiforme10.5
25myositis10.5
26tinea corporis10.5
27panuveitis10.5IFNA2
28degos disease10.5APOH
29polyarteritis nodosa10.5IFNA2
30lymphomatoid granulomatosis10.4IFNA2
31hemophagocytic lymphohistiocytosis10.4PRF1
32myocarditis10.4PRF1
33leprosy10.4MBD1
34stomatitis10.4IFNA2
35pityriasis rubra pilaris10.3
36chilblain lupus10.3
37renal cell carcinoma10.3
38cholangiocarcinoma10.3
39crohn's disease10.3
40molluscum contagiosum10.3
41acute pancreatitis10.3
42methemoglobinemia10.3
43herpes zoster10.3
44epidermolysis bullosa acquisita10.3
45keratoconjunctivitis sicca10.3
46sjogren's syndrome10.3
47mixed connective tissue disease10.3
48inclusion body myositis10.3
49adenocarcinoma10.3
50angioedema10.3

Graphical network of the top 20 diseases related to Subacute Cutaneous Lupus Erythematosus:



Diseases related to subacute cutaneous lupus erythematosus

Symptoms for Subacute Cutaneous Lupus Erythematosus

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Drugs & Therapeutics for Subacute Cutaneous Lupus Erythematosus

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Drug clinical trials:

Search ClinicalTrials for Subacute Cutaneous Lupus Erythematosus

Search NIH Clinical Center for Subacute Cutaneous Lupus Erythematosus

Genetic Tests for Subacute Cutaneous Lupus Erythematosus

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Anatomical Context for Subacute Cutaneous Lupus Erythematosus

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MalaCards organs/tissues related to Subacute Cutaneous Lupus Erythematosus:

31
Skin, T cells, Lung, Breast, Brain, Prostate, Testes

Animal Models for Subacute Cutaneous Lupus Erythematosus or affiliated genes

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MGI Mouse Phenotypes related to Subacute Cutaneous Lupus Erythematosus:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5MBD4, MBD3, ACE, PRF1, TNF
2MP:00053847.4C1QA, TYK2, TNF, PRF1, ACE, MBD3
3MP:00053766.8APOH, TRIM21, MBD3, ACE, PRF1, IRF5
4MP:00107686.8APOH, CTLA4, MBD4, MBD3, ACE, PRF1
5MP:00053976.7CTLA4, CD70, ACE, PRF1, IRF5, TNF
6MP:00053876.4C1QA, MBD3, TRIM21, CTLA4, CD70, ACE

Publications for Subacute Cutaneous Lupus Erythematosus

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Articles related to Subacute Cutaneous Lupus Erythematosus:

(show top 50)    (show all 278)
idTitleAuthorsYear
1
Minocycline: a new molecule inducing subacute cutaneous lupus erythematosus? (25876148)
2015
2
Subacute cutaneous lupus erythematosus onset preceded by Kikuchi-Fujimoto disease. (24520513)
2014
3
An uncommon cutaneous reaction for a common drug. Diagnosis: Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE). (25244994)
2014
4
Annular subacute cutaneous lupus erythematosus lesions and polymyositis onset in a patient with primary Sjogren's syndrome: how should this unusual association be classified? (23358869)
2013
5
A case of subacute cutaneous lupus erythematosus in a patient with mixed connective tissue disease: successful treatment with plasmapheresis and rituximab. (23984162)
2013
6
A case of subacute cutaneous lupus erythematosus as a result of ranibizumab (Lucentis) treatment. (24212210)
2013
7
Subacute cutaneous lupus erythematosus after treatment with capecitabine. (22937906)
2013
8
Toxic epidermal necrolysis-like subacute cutaneous lupus erythematosus. (23157783)
2012
9
Subacute Cutaneous Lupus Erythematosus Presenting in Childhood: A Case Report and Review of the Literature. (23106790)
2012
10
Atypical subacute cutaneous lupus erythematosus presenting as lichen planus pemphigoides with autoantibodies to C-terminus of BP180, desmoglein 1 and SS-A/Ro antigen. (22413755)
2012
11
Consider drugs as a cause or an exacerbating factor in patients diagnosed with subacute cutaneous lupus erythematosus! (22835019)
2012
12
Subacute cutaneous lupus erythematosus due to proton pump inhibitor intake: case report and literature review. (23056090)
2012
13
Variable presentations of subacute cutaneous lupus erythematosus. (20642992)
2010
14
Subacute cutaneous lupus erythematosus associated with capecitabine monotherapy. (19289781)
2009
15
Terbinafine-induced subacute cutaneous lupus erythematosus. (18441768)
2008
16
Subacute cutaneous lupus erythematosus and interstitial myositis occurring with hepatitis B infection: response to antiviral therapy with lamivudine. (18664991)
2008
17
Occurrence of subacute cutaneous lupus erythematosus after treatment with fluorouracil and capecitabine. (18625380)
2008
18
Subacute cutaneous lupus erythematosus with bullae associated with porphyria cutanea tarda. (17338797)
2007
19
Subacute cutaneous lupus erythematosus on the lines of Blaschko. (16709500)
2006
20
Subacute cutaneous lupus erythematosus: 25-year evolution of a prototypic subset (subphenotype) of lupus erythematosus defined by characteristic cutaneous, pathological, immunological, and genetic findings. (15990071)
2005
21
Bupropion-induced subacute cutaneous lupus erythematosus. (16197429)
2005
22
Kikuchi's disease (necrotizing lymphadenitis) with cutaneous involvement associated with subacute cutaneous lupus erythematosus. (15115501)
2004
23
Bullous subacute cutaneous lupus erythematosus. (15115507)
2004
24
Successful treatment of subacute cutaneous lupus erythematosus with mycophenolate mofetil. (12100205)
2002
25
Frequency and severity of systemic disease in patients with subacute cutaneous lupus erythematosus. (12224978)
2002
26
Subacute cutaneous lupus erythematosus associated with hepatocellular carcinoma. (11309033)
2001
27
Erythema multiforme-like subacute cutaneous lupus erythematosus: a new variety? (11028873)
2000
28
Subacute cutaneous lupus erythematosus presenting with generalized poikiloderma. (10642688)
2000
29
The cutaneous pathology associated with seropositivity for antibodies to SSA (Ro): a clinicopathologic study of 23 adult patients without subacute cutaneous lupus erythematosus. (10218672)
1999
30
Lichenoid and subacute cutaneous lupus erythematosus-like dermatitis associated with antihistamine therapy. (10082400)
1999
31
Paraneoplastic subacute cutaneous lupus erythematosus: report of a case associated with cancer of the lung. (9094469)
1997
32
Rapid improvement of subacute cutaneous lupus erythematosus with low-dose methotrexate. (9187859)
1997
33
Leukocytoclastic vasculitis in subacute cutaneous lupus erythematosus: clinicopathologic study of three cases and review of the literature. (8944346)
1996
34
Childhood subacute cutaneous lupus erythematosus associated with homozygous complement 2 deficiency. (8747579)
1995
35
Subacute cutaneous lupus erythematosus associated with chronic interstitial pneumonitis. (7607798)
1995
36
Coexisting lichen planus and subacute cutaneous lupus erythematosus. (7671426)
1995
37
Pityriasis rubra pilaris presenting as subacute cutaneous lupus erythematosus. (8243104)
1993
38
A characteristic cutaneous direct immunofluorescent pattern associated with Ro(SS-A) antibodies in subacute cutaneous lupus erythematosus. (1430355)
1992
39
Figurate erythema, photosensitivity, and conjunctival irritation of recent onset. Subacute cutaneous lupus erythematosus (SCLE) and keratoconjunctivitis sicca. (1519943)
1992
40
Possible naproxen-induced relapse of subacute cutaneous lupus erythematosus. (1535107)
1992
41
Detection of anti-Ro(SSA) antibodies by gel double diffusion and a 'sandwich' ELISA in systemic and subacute cutaneous lupus erythematosus and SjAPgren's syndrome. (1903247)
1991
42
Response of discoid and subacute cutaneous lupus erythematosus to recombinant interferon alpha 2a. (2258631)
1990
43
IgG subclasses in the serum and skin in subacute cutaneous lupus erythematosus and neonatal lupus erythematosus. (2250107)
1990
44
Comparison of IgG subclass autoantibodies in patients with systemic lupus erythematosus and subacute cutaneous lupus erythematosus. (2085508)
1990
45
Subacute cutaneous lupus erythematosus in Greece. A clinical, serological and genetic study. (2256585)
1990
46
Pattern of cutaneous immunoglobulin G deposition in subacute cutaneous lupus erythematosus is reproduced by infusing purified anti-Ro (SSA) autoantibodies into human skin-grafted mice. (2651477)
1989
47
Subacute cutaneous lupus erythematosus presenting as erythroderma. (2970478)
1988
48
Subacute cutaneous lupus erythematosus. Clinical, serologic, immunogenetic, and therapeutic considerations in seventy-two patients. (3261587)
1988
49
Relationships between antinuclear and anti-Ro/SS-A antibodies in subacute cutaneous lupus erythematosus. (6384294)
1984
50
Human histocompatibility antigen associations in subacute cutaneous lupus erythematosus. (7451656)
1981

Variations for Subacute Cutaneous Lupus Erythematosus

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Expression for genes affiliated with Subacute Cutaneous Lupus Erythematosus

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Search GEO for disease gene expression data for Subacute Cutaneous Lupus Erythematosus.

Pathways for genes affiliated with Subacute Cutaneous Lupus Erythematosus

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Pathways related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TYK2, PRF1
29.5IFNA2, IFNA1
39.5IFNA2, IFNA1
49.5TNF, TYK2
5
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.3PRF1, IRF5, TNF
6
Show member pathways
9.2IFNA1, IFNA2, TRIM21
7
Show member pathways
Type III interferon signaling36
9.2TYK2, IFNA1, IFNA2
89.2IFNA2, IFNA1, TYK2
9
Show member pathways
9.0TRIM21, MBD3, TNF, C1QA
10
Show member pathways
9.0TYK2, IRF5, IFNA1, IFNA2
11
Show member pathways
9.0TYK2, IRF5, IFNA1, IFNA2
12
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
8.9IFNA2, IFNA1, TNF
138.9IFNA2, IFNA1, TNF
14
Show member pathways
8.9IFNA2, IFNA1, TNF
158.9IFNA2, IFNA1, TNF
16
Show member pathways
Immune response CD16 signaling in NK cells58
8.6TNF, PRF1, IFNA1, IFNA2
178.6TYK2, TNF, IFNA1, IFNA2
18
Show member pathways
8.6TYK2, TNF, IFNA1, IFNA2
19
Show member pathways
8.6TYK2, TNF, IFNA1, IFNA2
20
Show member pathways
8.2CTLA4, IFNA2, IFNA1, PRF1, TNF
21
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
7.9ACE, IFNA2, IFNA1, IRF5, TNF, C1QA
22
Show member pathways
7.8CD70, IFNA2, IFNA1, TNF, TYK2

Compounds for genes affiliated with Subacute Cutaneous Lupus Erythematosus

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Compounds related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1pegasys4310.0IFNA2, IFNA1
2alefacept43 1211.0TNF, C1QA
3entecavir4310.0IFNA1, IFNA2
4efalizumab43 1211.0TNF, C1QA
5intron a439.9IFNA2, IFNA1
6famciclovir43 1210.9IFNA1, IFNA2
7atpo28 4310.9APOH, IFNA1
8mizoribine439.9IFNA2, IFNA1
9n-phosphonacetyl-l-aspartate439.9IFNA2, IFNA1
10anagrelide43 1210.9IFNA1, IFNA2
11lomustine43 1210.9IFNA2, IFNA1
12pentostatin43 59 28 1212.9IFNA1, IFNA2
13natalizumab43 1210.9TNF, C1QA
145-deoxy-5-fluorouridine439.9IFNA1, IFNA2
15adefovir439.9IFNA1, IFNA2
16amantadine43 1210.9IFNA2, IFNA1
17didanosine43 49 1211.8IFNA1, IFNA2
18abatacept43 1210.8CTLA4, TNF
19acitretin43 1210.8IFNA1, IFNA2
20glatiramer acetate43 1210.8IFNA1, CTLA4
21levamisole43 1210.8IFNA1, IFNA2
22busulfan43 49 1211.7IFNA1, IFNA2
23dacarbazine43 1210.6IFNA2, IFNA1
24ifn-alpha439.6TYK2, IFNA1, IFNA2
25procainamide43 1210.6APOH, CD70
265-aza-2deoxycytidine439.5MBD4, MBD1, IFNA1
27hydroxychloroquine43 1210.5IFNA2, APOH, TNF
28acyclovir43 1210.4IFNA1, IFNA2
29cyclophosphamide43 49 1211.4IFNA2, IFNA1, APOH
30imiquimod43 59 28 1212.4TNF, IFNA2, IFNA1
312,5-oligoadenylate439.3TNF, IFNA2, IFNA1
32hydralazine43 49 1211.3CD70, ACE
33neopterin439.3IFNA1, TNF, IFNA2
34indoleamine439.3IFNA1, CTLA4, TNF
35mycophenolate mofetil43 49 1211.3IFNA1, CTLA4, TNF
36etanercept43 49 1211.3C1QA, APOH, IFNA2, TNF
37superoxide43 2410.1TNF, IFNA2, PRF1, APOH
38infliximab43 49 1211.1TNF, IFNA2, APOH, CTLA4
39il-12439.0IFNA1, TNF
40prednisolone43 28 1211.0TNF, APOH, IFNA1, IFNA2
41zinc43 2410.0ACE, TRIM21, MBD4, IFNA2, APOH
42prostacyclin439.0ACE, TNF, APOH
43melphalan43 49 1210.9IFNA2, TNF, IFNA1, CTLA4
44thalidomide43 49 59 1211.9TNF, CTLA4, IFNA2, IFNA1
45tacrolimus43 49 1210.9IFNA1, TNF, CTLA4
46thymidine43 249.8IFNA2, IFNA1, CTLA4, TNF
47ionomycin438.8CTLA4, CD70, TNF
48vegf438.7APOH, IFNA2, IFNA1, IRF5, TNF
49rantes438.5CTLA4, CD70, IFNA1, TNF
50rituximab43 49 1210.3IFNA2, APOH, CTLA4, TNF, C1QA, IFNA1

GO Terms for genes affiliated with Subacute Cutaneous Lupus Erythematosus

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Cellular components related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.9CTLA4, ACE, TNF
2extracellular spaceGO:00056157.4CD70, ACE, IFNA2, APOH, TNF

Biological processes related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of type I interferon-mediated signaling pathwayGO:00603389.7IFNA2, TYK2
2type I interferon signaling pathwayGO:00603379.6IRF5, IFNA2, TYK2
3defense response to virusGO:00516079.6PRF1, IFNA2, IRF5
4cytokine-mediated signaling pathwayGO:00192219.4IRF5, IFNA2, TYK2
5extrinsic apoptotic signaling pathwayGO:00971919.0CD70, TNF
6cell-cell signalingGO:00072678.7CD70, C1QA, IFNA2

Molecular functions related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1methyl-CpG bindingGO:00083279.8MBD3, MBD1
2tumor necrosis factor receptor bindingGO:00051649.0CD70, TNF
3cytokine activityGO:00051258.3CD70, IFNA2, TNF
4protein bindingGO:00055155.0TRIM21, C1QA, TYK2, TNF, APOH, IRF5

Products for genes affiliated with Subacute Cutaneous Lupus Erythematosus

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  • Antibodies
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  • Kits and Assays

Sources for Subacute Cutaneous Lupus Erythematosus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet