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SSPE
MCID: SBC001
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Subacute Sclerosing Panencephalitis malady |
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Sources: 6Disease Ontology, 31NINDS, 44Wikipedia, 22MalaCards See all sources Export this MalaCard |
NINDS: Subacute sclerosing panencephalitis (SSPE) is a progressive neurological disorder of children and young adults that affects
the central nervous system (CNS). It is a slow, but persistent, viral infection caused by defective measles virus. SSPE has
been reported from all parts of the world, but it is considered a rare disease in developed countries, with fewer than 10
cases per year reported in the United States. The incidence of SSPE declined by at least 90 percent in countries that have
practiced widespread immunization with measles vaccine. The incidence of SSPE is still high in developing countries such as
India and Eastern Europe. There is a higher incidence among males than females (male/female: 3/1). Most youngsters with SSPE
have a history of measles infection at an early age, usually younger than 2 years, followed by a latent period of 6 to 8 years
before neurological symptoms begin. Despite the long interval between the measles infection and the onset of SSPE, researchers
think that the infection of the brain occurs soon after the primary bout with measles and progresses slowly. Why it persists
and progresses still isn't clear. The initial symptoms of SSPE are subtle and include mild mental deterioration (such as memory
loss) and changes in behavior (such as irritability) followed by disturbances in motor function, including uncontrollable
involuntary jerking movements of the head, trunk or limbs called myoclonic jerks. Seizures may also occur. Some people may
become blind. In advanced stages of the disease, individuals may lose the ability to walk, as their muscles stiffen or spasm.
There is progressive deterioration to a comatose state, and then to a persistent vegetative state. Death is usually the result
of fever, heart failure, or the brain's inability to continue controlling the autonomic nervous system.31
MalaCards: Subacute Sclerosing Panencephalitis, also known as van bogaert's sclerosing leukoencephalitis (disorder), is related to stomatitis and encephalitis. An important gene associated with Subacute Sclerosing Panencephalitis is SLAMF1 (signaling lymphocytic activation molecule family member 1), and among its related pathways are Bacterial infections in CF airways and Graft-versus-host disease. The compounds ivig and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and heart, and related mouse phenotypes are respiratory system and homeostasis/metabolism. Disease Ontology: A viral infectious disease that results in infection located in brain, has material basis in measles virus which is immune resistant (which can be a result of a mutation of the virus itself).6 Wikipedia: Subacute sclerosing panencephalitis (SSPE) is a rare chronic, progressive encephalitis that affects...44 more... |
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Sources: 6Disease Ontology, 30NIH Rare Diseases, 31NINDS, 8DISEASES, 32Novoseek , 43UMLS, 33OMIM, 19ICD9CM, 40SNOMED-CT, 24MeSH, 27NCIt See all sources |
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Sources: 4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT See all sources |
Approved drugs:Search CenterWatch for subacute sclerosing panencephalitis Drug clinical trials:Search ClinicalTrials for subacute sclerosing panencephalitis Search NIH Clinical Center for subacute sclerosing panencephalitis Search CenterWatch for subacute sclerosing panencephalitis |
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Sources: 11FMA, 22MalaCards See all sources |
MalaCards organs/tissues related to subacute sclerosing panencephalitis:22Brain, Heart FMA organs/tissues related to subacute sclerosing panencephalitis:11Brain
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Sources: 25MGI See all sources |
MGI Mouse Phenotypes related to subacute sclerosing panencephalitis:25 (show all 20)
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Sources: 35PubMed See all sources |
Articles related to subacute sclerosing panencephalitis:(show all 36)
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Sources: 1BioGPS See all sources |
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Sources: 41Thomson Reuters, 20KEGG, 36QIAGEN, 38Reactome, 10EMD Millipore, 37R&D Systems See all sources |
Pathways related to subacute sclerosing panencephalitis according to GeneDecks:(show top 50) (show all 100)
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Sources: 32Novoseek , 42Tocris Bioscience, 9DrugBank, 18HMDB, 34PharmGKB See all sources |
Compounds related to subacute sclerosing panencephalitis according to GeneDecks:(show top 50) (show all 226)
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Sources: 12Gene Ontology See all sources |
Cellular components related to subacute sclerosing panencephalitis according to GeneDecks:
Biological processes related to subacute sclerosing panencephalitis according to GeneDecks:(show all 48)
Molecular functions related to subacute sclerosing panencephalitis according to GeneDecks:
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