MCID: SBC007
MIFTS: 58

Subacute Thyroiditis malady

Endocrine diseases category

Summaries for Subacute Thyroiditis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Subacute thyroiditis is a form of thyroiditis that can be a cause of both thyrotoxicosis and... more...

MalaCards: Subacute Thyroiditis, also known as subacute granulomatous thyroiditis, is related to thyroiditis and graves' disease. An important gene associated with Subacute Thyroiditis is CA1 (carbonic anhydrase I), and among its related pathways are MAPK signaling pathway and CREB Pathway. The compounds estrogen and pge2 have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and pituitary, and related mouse phenotypes are vision/eye and cardiovascular system.

Aliases & Classifications for Subacute Thyroiditis

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 34MeSH, 56SNOMED-CT, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

subacute thyroiditis 8 10 60
subacute granulomatous thyroiditis 8
de quervain's thyroiditis 8
granulomatous thyroiditis 8
giant-cell thyroiditis 8
thyroiditis subacute 44


External Ids:

Disease Ontology8 DOID:7165
MeSH34 D013968
ICD9CM27 245.1
ICD1025 E06.1

Related Diseases for Subacute Thyroiditis

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17GeneCards, 18GeneDecks
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Diseases in the Autoimmune Thyroiditis family:

Acute Thyroiditis subacute thyroiditis
Thyroiditis

Diseases related to Subacute Thyroiditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 275)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.8TG, TPO
2graves' disease30.8TG, TPO, IL1RN, IL2RA, SHBG, ICAM1
3hyperthyroidism30.8TG, TPO, SHBG, CA1, BGLAP
4hypothyroidism30.7TG, TPO, SHBG
5hepatitis30.5GGT1
6thyrotoxicosis30.5TG, TPO
7autoimmune thyroiditis30.4TG, TPO
8influenza30.4IFNG
9hepatitis b30.3TGFB1, GGT1, IL2RA, IFNG
10hypercalcemia30.2BGLAP
11papillary thyroid carcinoma30.2TG, TPO, EGF
12hepatitis c30.2GGT1, IL1R1, IFNG
13arthritis30.1TGFB1, IL6, IL1B, IL1R1, IL1RN, FGF2
14vasculitis29.9ICAM1
15pituitary adenoma29.9FGF2
16encephalitis29.9IL1B
17hypoparathyroidism29.9NAGLU, BGLAP
18goiter29.9TG, TPO, BGLAP
19severe combined immunodeficiency29.9IL2RA, IFNG
20thyroid cancer29.9TG, TPO, BAK1, EGF
21adenoma29.9TG, TPO, GGT1, BAK1, SHBG, CA1
22systemic lupus erythematosus29.9TPO, IL6, IL1R1, IL1RN, IL2RA, ICAM1
23ulcerative colitis29.9IL6, IL1B, IL1R1, IL1RN, IL2RA, ICAM1
24rheumatoid arthritis29.9IL6, IL1B, IL1R1, IL1RN, IL2RA, NAGLU
25acute thyroiditis10.5
26subacute lymphocytic thyroiditis10.4
27papillary carcinoma10.1
28thyroid lymphoma10.1
29lung giant cell carcinoma10.1
30myocarditis10.1
31acute myocardial infarction10.0NAGLU
32cystic fibrosis10.0IL1R1
33alopecia10.0SHBG
34cataract10.0IL1R1
35common variable immune deficiency10.0IL2RA
36laryngeal benign neoplasm10.0BAK1
37acne10.0SHBG
38polycystic ovary syndrome10.0SHBG
39polymyalgia rheumatica10.0IL1RN
40testicular cancer10.0SHBG
41pyelonephritis10.0NAGLU
42dementia10.0TPO
43hypercholesterolemia10.0GGT1
44duodenal ulcer10.0IL1RN
45papilloma10.0BAK1
46down syndrome10.0TPO
47hyperprolactinemia10.0SHBG
48viral hepatitis10.0GGT1
49oral cancer10.0GGT1
50neutropenia10.0IL1RN

Graphical network of the top 20 diseases related to Subacute Thyroiditis:



Diseases related to subacute thyroiditis

Clinical Features for Subacute Thyroiditis

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Drugs & Therapeutics for Subacute Thyroiditis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Subacute Thyroiditis

Drug clinical trials:

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Search NIH Clinical Center for Subacute Thyroiditis

Search CenterWatch for Subacute Thyroiditis

Genetic Tests for Subacute Thyroiditis

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Anatomical Context for Subacute Thyroiditis

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32MalaCards
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MalaCards organs/tissues related to Subacute Thyroiditis:

32
Thyroid, Testes, Pituitary, Bone marrow, Bone, Liver, T cells, Lung, B cells

Animal Models for Subacute Thyroiditis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Subacute Thyroiditis:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.8EGF, NAGLU, FGF2, IL1R1
2MP:00053859.1IFNG, NAGLU, IL1RN, IL1R1, IL1B
3MP:00036319.0BAK1, NAGLU, TG, TGFB1
4MP:00107718.9NAGLU, IL1R1, IL6, GGT1, TGFB1
5MP:00053798.7IFNG, ICAM1, EGF, IL1R1, IL6, TG
6MP:00020068.7IFNG, ICAM1, IL1R1, IL1B, IL6, TGFB1
7MP:00053768.5IFNG, ICAM1, IL1RN, IL1R1, GGT1, TPO
8MP:00053908.3BAK1, NAGLU, FGF2, IL1B, IL6, GGT1
9MP:00053847.6ICAM1, BAK1, NAGLU, FGF2, IL2RA, IL1RN
10MP:00053787.2IFNG, ICAM1, EGF, NAGLU, IL2RA, IL1RN
11MP:00053976.8TGFB1, IFNG, ICAM1, BAK1, NAGLU, FGF2
12MP:00053876.6NAGLU, BAK1, EGF, ICAM1, IFNG, IL2RA
13MP:00107686.6FGF2, NAGLU, BAK1, ICAM1, IFNG, IL2RA

Publications for Subacute Thyroiditis

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50PubMed
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Articles related to Subacute Thyroiditis:

(show top 50)    (show all 356)
idTitleAuthorsYear
1
Follow-up of a case of subacute thyroiditis with uncommon thyroid 99mTc uptake. (24343637)
2013
2
Subacute thyroiditis presenting as acute psychosis: a case report and literature review. (23526704)
2013
3
A Case of Painful Hashimoto Thyroiditis that Mimicked Subacute Thyroiditis. (22570820)
2012
4
Subacute, silent, and postpartum thyroiditis. (22443972)
2012
5
Expanded dengue syndrome: subacute thyroiditis and intracerebral hemorrhage. (23033818)
2012
6
Thyroglobulin autoantibodies of patients with subacute thyroiditis are restricted to a major B cell epitope. (23014133)
2012
7
A case of subacute thyroiditis associated with primary HIV infection. (19332218)
2009
8
Subacute thyroiditis confused with dental problem. (19899734)
2009
9
An infant with cytomegalovirus-induced subacute thyroiditis. (18422033)
2008
10
Primary thyroid lymphoma mimicking subacute thyroiditis. (17152291)
2006
11
Subacute thyroiditis developed in identical twins two years apart. (16284433)
2005
12
Familial occurrence of subacute thyroiditis associated with human leukocyte antigen-B35. (15307945)
2004
13
Technetium-99 m sestamibi imaging in patients with subacute thyroiditis. (12940451)
2003
14
Subacute thyroiditis in a single lobe. (11317018)
2001
15
Subacute thyroiditis presenting as pyrexia of unknown origin in a patient with human immunodeficiency virus infection. (10525005)
1999
16
Subacute thyroiditis in a patient with MS treated with interferon beta-1a. (10534282)
1999
17
Technetium-99m tetrofosmin imaging in patients with subacute thyroiditis. (9818287)
1998
18
De Quervain's subacute thyroiditis presenting as a painless solitary thyroid nodule. (10211354)
1998
19
Incidence of subacute thyroiditis recurrences after a prolonged latency: 24-year survey. (8636251)
1996
20
Soluble intercellular adhesion molecule-1 concentrations in patients with subacute thyroiditis and in patients with Graves' disease with or without ophthalmopathy. (8980891)
1996
21
Simultaneous onset of giant cell arteritis and subacute thyroiditis. (8250621)
1993
22
CA 19-9 expression in subacute (de Quervain's) thyroiditis: an immunohistochemical study. (1495932)
1992
23
Subacute thyroiditis. (1877246)
1991
24
Sonography of subacute thyroiditis: changes in the findings during the course of the disease. (2152779)
1990
25
Subacute thyroiditis--61 cases review. (2766065)
1989
26
Effect of prednisolone and salicylate on serum thyroglobulin level in patients with subacute thyroiditis. (3427792)
1987
27
Persistent thyroid autoimmunity after subacute thyroiditis. (2441062)
1987
28
Subacute thyroiditis after bone marrow transplant for chronic granulocytic leukaemia. (3332149)
1987
29
Sinus histiocytosis with massive lymphadenopathy simulating subacute thyroiditis. (3512416)
1986
30
Occult subacute thyroiditis with unusual features. (2863709)
1985
31
Graves' disease following acute (subacute) thyroiditis. (583118)
1979
32
A clinical study of subacute thyroiditis of de Quervain in Iraq. (532897)
1979
33
Typical and atypical ('silent') subacute thyroiditis in a wife and husband. (619831)
1978
34
Subacute thyroiditis with increased serum alkaline phosphatase. (25034)
1978
35
Subacute thyroiditis. Eleven cases with histological confirmation and thyrotrophic response to thyrotrophin releasing hormone. (56865)
1976
36
Painless subacute thyroiditis simulating Graves' disease. (947277)
1976
37
Subacute thyroiditis associated with lymphosarcoma of the thyroid. (1173065)
1975
38
Isolation and some serological and epidemiological data on the viruses recovered from patients with subacute thyroiditis de Quervain. (806773)
1975
39
Medical grand rounds from the West Virginia University Medical Center. 2. Subacute thyroiditis. (4524739)
1974
40
Subacute (giant cell) thyroiditis and giant cell myocarditis in patient with carcinoma of lung. (4760024)
1973
41
Serum thyroxine in the early phase of subacute thyroiditis. (4194317)
1970
42
Subacute thyroiditis. (13625584)
1959
43
Thyroid function in subacute thyroiditis. (13491686)
1958
44
Subacute thyroiditis: a disease commonly mistaken for pharyngitis. (13446815)
1957
45
Subacute thyroiditis. (13487229)
1957
46
Some new observations on subacute thyroiditis. (13385293)
1956
47
Subacute thyroiditis (nodular type); report of 9 cases. (13318559)
1956
48
WEEKLY clinicopathological exercise: subacute thyroiditis. (14919910)
1952
49
Acute and subacute thyroiditis. (15425440)
1950
50
Subacute thyroiditis. (15409440)
1950

Genetic Variations for Subacute Thyroiditis

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Expression for genes affiliated with Subacute Thyroiditis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Subacute Thyroiditis

Search GEO for disease gene expression data for Subacute Thyroiditis.

Pathways for genes affiliated with Subacute Thyroiditis

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Sources:
37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 52R&D Systems, 12EMD Millipore, 59Tocris Bioscience, 53Reactome
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Pathways related to Subacute Thyroiditis according to GeneCards/GeneDecks:

(show all 50)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.3IL1R1
2
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10.3IL2RA
3
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10.3IL2RA
410.2TGFB1
510.2IL1B
6
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.1IFNG
710.1IL1R1, IL2RA
8
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10.1TPO, TG
9
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10.0EGF, IL2RA
10
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9.8IL2RA, IL1R1, TGFB1
11
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9.8TPO, TG, TGFB1
12
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9.7TPO, IL2RA, EGF
13
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9.7IL2RA, IL1R1, IL1B
14
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9.7IL1RN, IL1R1, IL1B
15
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9.7IL2RA, FGF2, EGF
169.6IFNG, IL2RA, TGFB1
17
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9.6IL1R1, IL1B, IL6
189.6IFNG, ICAM1, IL1B
19
Immune response IFN gamma signaling pathway
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9.6IL1B, ICAM1, IFNG
20
Cytokine production by Th17 cells in CF (Mouse model)
9.5TGFB1, IL6, ICAM1
219.5IFNG, EGF, TGFB1
229.5IFNG, ICAM1, IL6
239.4IL6, IL1B, IFNG
249.4IL6, IL1B, IFNG
259.4TGFB1, IL1R1, FGF2, EGF
26
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9.4EGF, BAK1, FGF2
27
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9.4IFNG, IL2RA, IL1R1, IL1B
289.3IFNG, IL1R1, IL1B, TGFB1
299.3TPO, IL6, IL2RA, IFNG
30
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9.2IFNG, IL1R1, IL1B, IL6
319.2IL6, IL1B, ICAM1, IFNG
329.2IFNG, EGF, IL6, TGFB1
33
Development PDGF signaling via STATs and NF-kB
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9.2IL6, IL1B, FGF2, IFNG
34
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9.1TGFB1, IL6, IL1B, IFNG
359.1IL2RA, IL1R1, IL1B, IL6, TPO
36
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9.1IL2RA, IL1RN, IL1R1, IL1B, IL6
37
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9.1IFNG, EGF, IL2RA, IL1R1, IL1B
389.1BGLAP, ICAM1, TGFB1
399.0TGFB1, IL6, IL1B, IL1R1, ICAM1
40
Immune response Bacterial infections in normal airways
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9.0IFNG, IL1RN, IL1R1, IL1B, IL6
41
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9.0IFNG, ICAM1, IL2RA, IL1B, IL6
42
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9.0IFNG, ICAM1, IL2RA, IL1B, IL6
438.9IFNG, IL1R1, IL1B, IL6, TGFB1
44
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8.9TGFB1, IL6, IL1B, IL1R1, IFNG
45
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8.7BAK1, FGF2, IL1B, IL6, TGFB1
468.7IL6, ICAM1, IFNG, BGLAP
478.6IFNG, ICAM1, IL1B, IL6, GGT1
48
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8.5IFNG, ICAM1, IL2RA, IL1RN, IL1R1, IL1B
49
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8.5EGF, FGF2, IL2RA, IL1R1, IL1B, IL6
50
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8.0IFNG, ICAM1, EGF, FGF2, IL2RA, IL1RN

Compounds for genes affiliated with Subacute Thyroiditis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Subacute Thyroiditis according to GeneCards/GeneDecks:

(show top 50)    (show all 212)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6TG
2pge24410.6TGFB1
3pirfenidone44 5911.5IL1B
4cuprophan4410.1ICAM1, IL2RA, IL1R1
5gm-csf44 2811.0IFNG, ICAM1
6polysaccharide449.9TG, TPO, IL2RA, SHBG
7indomethacin44 59 28 1112.9GGT1, IL1R1, CA1
8ivig449.9IFNG, IL1RN, IL1R1, TG
9pentoxifylline44 1110.7NAGLU, IL1RN, IL1R1, GGT1
10alginate449.4BGLAP, IL1RN
11gold sodium thiomalate449.4IFNG, NAGLU, IL1R1, IL2RA, IL1B, IL1RN
12sulfasalazine44 28 49 1112.4IL1B, ICAM1, IL1R1, IL1RN, IL2RA
13bucillamine449.3IL1B, IL6, FGF2, IFNG
14hydrocortisone44 2 59 1112.2BGLAP, SHBG, FGF2, TPO, TG
15carbimazole44 1110.2IL2RA, BGLAP, TPO, SHBG
16polymyxin b449.2IFNG, IL1RN, IL1B, IL6, ICAM1
17heparin44 28 11 2412.1BGLAP, IL1RN, IL1R1, IL2RA, NAGLU
18anakinra44 1110.0IL1RN, IL1R1, IL1B, IL6
19prednisolone44 28 1111.0SHBG, FGF2, IL2RA, IL1R1, BGLAP, TG
20etanercept44 49 1111.0IL6, IL1R1, IL1RN, IFNG, IL1B
21thalidomide44 49 59 1112.0IL1B, IL1R1, IL2RA, FGF2, IL6, IFNG
22vitamin d449.0IL6, IL1R1, IL2RA, NAGLU, BGLAP
23il 10448.9IL1RN, IFNG, IL1R1, IL1B, TGFB1, IL6
24rantes448.8IL6, IL1B, IL1R1, IL2RA, ICAM1, IFNG
25neopterin448.8ICAM1, IL1B, IL1R1, IL1RN, IL6, NAGLU
26herbimycin a44 599.7IL6, IFNG, FGF2, IL2RA, IL1B, ICAM1
27methimazole44 2 1110.7BGLAP, TG, ICAM1, IL2RA, TPO
28ns 39844 599.6FGF2, IL1RN, BGLAP, IL1B, TGFB1
29cyclosporin a44 28 5910.4FGF2, IL2RA, TG, IL1R1, NAGLU, ICAM1
30methotrexate44 49 1110.4NAGLU, TGFB1, IL6, IL1B, IL1R1, IL1RN
31lactate448.2TG, TGFB1, IL1R1, IL1RN, NAGLU, SHBG
32thymidine44 249.2FGF2, IFNG, EGF, NAGLU, TGFB1, IL2RA
33genistein44 28 59 2 11 2413.2IL2RA, IL6, TPO, IL1B, FGF2, SHBG
34thyroxine44 249.1BGLAP, SHBG, FGF2, GGT1, TPO, TG
35hyaluronic acid44 249.1GGT1, IL1B, IL1R1, IL1RN, NAGLU, ICAM1
36creatinine448.1TGFB1, TG, TPO, GGT1, IL1RN, NAGLU
37actinomycin d448.0EGF, IL1R1, IL1B, ICAM1, TGFB1, IL6
38histamine44 28 249.9BGLAP, IL1RN, ICAM1, IL1B, IL6, TGFB1
39h2o2447.7BGLAP, ICAM1, FGF2, IL1RN, IL1R1, IL2RA
40ascorbic acid44 248.6SHBG, ICAM1, IL1R1, IL2RA, IL1RN, BGLAP
41infliximab44 49 119.6IFNG, IL1R1, IL1B, IL6, BAK1, FGF2
42dexamethasone44 49 28 1110.6BGLAP, SHBG, BAK1, FGF2, IL6, GGT1
43sb 20358044 598.5IFNG, BGLAP, EGF, FGF2, ICAM1, IL1B
44cisplatin44 49 59 1110.5NAGLU, BAK1, EGF, BGLAP, IL2RA, IL1R1
45testosterone44 59 11 2410.4IL1RN, IL2RA, SHBG, EGF, IL1R1, IL6
46calcitriol44 59 11 2410.1TGFB1, TG, IL6, BGLAP, IFNG, EGF
47vegf447.0IL1R1, IFNG, EGF, BGLAP, FGF2, IL2RA
48cysteine446.9IL2RA, BAK1, IL1R1, GGT1, TPO, EGF
49alanine446.9BGLAP, NAGLU, TG, GGT1, IL6, SHBG
50retinoic acid44 247.3SHBG, FGF2, BAK1, TG, BGLAP, IFNG

GO Terms for genes affiliated with Subacute Thyroiditis

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16Gene Ontology
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Cellular components related to Subacute Thyroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3IL6, IL2RA, ICAM1, IFNG
2extracellular spaceGO:0056157.0TGFB1, BGLAP, IFNG, ICAM1, EGF, FGF2
3extracellular regionGO:0055766.9BGLAP, IFNG, EGF, SHBG, FGF2, IL1R1

Biological processes related to Subacute Thyroiditis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cerebellar granule cell precursor proliferationGO:02194010.2EGF, FGF2
2positive regulation of calcidiol 1-monooxygenase activityGO:06055910.1IFNG, IL1B
3neutrophil apoptotic processGO:00178110.0IFNG, IL6
4positive regulation of interleukin-6 biosynthetic processGO:04541010.0IL1B, IFNG
5negative regulation of immune responseGO:0507779.9TGFB1, IL2RA
6positive regulation of chemokine biosynthetic processGO:0450809.8IL1B, IFNG
7positive regulation of cell divisionGO:0517819.8TGFB1, IL1B, FGF2
8positive regulation of T cell proliferationGO:0421029.7IFNG, IL1B, IL6
9positive regulation of NF-kappaB transcription factor activityGO:0510929.5ICAM1, IL1B, IL6, TGFB1
10positive regulation of nitric oxide biosynthetic processGO:0454299.5IL6, IL1B, ICAM1, IFNG
11cytokine-mediated signaling pathwayGO:0192219.3IFNG, ICAM1, IL1B, IL6
12response to glucocorticoid stimulusGO:0513849.2IL6, IL1RN, BGLAP
13positive regulation of apoptotic processGO:0430659.1TGFB1, IL6, IL2RA, BAK1
14positive regulation of transcription, DNA-dependentGO:0458939.0EGF, FGF2, IL1B, IL6, TGFB1
15negative regulation of cell proliferationGO:0082858.9TGFB1, IL6, IL1B, FGF2, BAK1
16response to ethanolGO:0454718.6BGLAP, ICAM1, BAK1
17response to drugGO:0424937.9TGFB1, BGLAP, IFNG, ICAM1, BAK1, IL1RN

Molecular functions related to Subacute Thyroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.2IL6, IL1B, FGF2, IFNG
2growth factor activityGO:0080839.0TGFB1, IL6, FGF2, EGF

Products for genes affiliated with Subacute Thyroiditis

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  • Antibodies
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Sources for Subacute Thyroiditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet