MCID: SBC007
MIFTS: 55

Subacute Thyroiditis malady

Endocrine category

Summaries for Subacute Thyroiditis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Subacute thyroiditis is a form of thyroiditis that can be a cause of both thyrotoxicosis and... more...

MalaCards: Subacute Thyroiditis, also known as subacute granulomatous thyroiditis, is related to thyroiditis and graves' disease. An important gene associated with Subacute Thyroiditis is CA1 (carbonic anhydrase I), and among its related pathways are MAPK signaling pathway and CREB Pathway. The compounds estrogen and pge2 have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and liver, and related mouse phenotypes are vision/eye and cardiovascular system.

Aliases & Classifications for Subacute Thyroiditis

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 45Novoseek, 35MeSH, 57SNOMED-CT, 40NCIt, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine


Aliases & Descriptions:

subacute thyroiditis 8 10 61
subacute granulomatous thyroiditis 8
de quervain's thyroiditis 8
granulomatous thyroiditis 8
giant-cell thyroiditis 8
thyroiditis subacute 45


External Ids:

Disease Ontology8 DOID:7165
MeSH35 D013968
ICD9CM27 245.1
ICD1025 E06.1

Related Diseases for Subacute Thyroiditis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the autoimmune thyroiditis family:

acute thyroiditis subacute thyroiditis
thyroiditis

Diseases related to Subacute Thyroiditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 276)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.9TG, TPO
2graves' disease30.9TG, TPO, IL1RN, IL2RA, SHBG, ICAM1
3thyrotoxicosis30.6TG, TPO
4hepatitis c30.4GGT1, IL1R1, IFNG
5autoimmune thyroiditis30.3TG, TPO
6hypercalcemia30.2BGLAP
7arthritis30.1TGFB1, IL6, IL1B, IL1R1, IL1RN, FGF2
8vasculitis30.0ICAM1
9nephritis30.0IL1R1, IL1RN
10hypoparathyroidism30.0NAGLU, BGLAP
11thyroid adenoma30.0TG, TPO, SHBG
12thyroid cancer30.0TG, TPO, BAK1, EGF
13adenoma30.0TG, TPO, GGT1, BAK1, SHBG, CA1
14systemic lupus erythematosus29.9TPO, IL6, IL1R1, IL1RN, IL2RA, ICAM1
15ulcerative colitis29.9IL6, IL1B, IL1R1, IL1RN, IL2RA, ICAM1
16acute thyroiditis10.5
17riedel thyroiditis10.3
18thyroid lymphoma10.2
19subacute lymphocytic thyroiditis10.2
20papillary carcinoma10.2
21q fever10.2
22hepatitis a10.2
23lung giant cell carcinoma10.1
24giant cell myocarditis10.1
25suppurative thyroiditis10.0
26cushing's syndrome10.0
27pharyngitis10.0
28iodine hypothyroidism10.0
29takayasu's arteritis10.0
30hepatitis d10.0
31lymphosarcoma10.0
32typhoid fever10.0
33temporal arteritis10.0
34mumps10.0
35cystic lymphangioma10.0
36amyloidosis10.0
37myopathy - thyrotoxic10.0
38hypothyroidism, autoimmune10.0
39hepatitis c virus10.0
40hemorrhage, intracerebral10.0
41sinusitis10.0
42acute myocardial infarction10.0NAGLU
43cystic fibrosis10.0IL1R1
44alopecia10.0SHBG
45cataract10.0IL1R1
46common variable immune deficiency10.0IL2RA
47laryngeal carcinoma10.0BAK1
48acne10.0SHBG
49polycystic ovary syndrome10.0SHBG
50polymyalgia rheumatica10.0IL1RN

Graphical network of the top 20 diseases related to Subacute Thyroiditis:



Diseases related to subacute thyroiditis

Clinical Features for Subacute Thyroiditis

Drugs & Therapeutics for Subacute Thyroiditis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Subacute Thyroiditis

Drug clinical trials:

Search ClinicalTrials for Subacute Thyroiditis

Search NIH Clinical Center for Subacute Thyroiditis

Search CenterWatch for Subacute Thyroiditis

Genetic Tests for Subacute Thyroiditis

Anatomical Context for Subacute Thyroiditis

Sources:
33MalaCards
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MalaCards organs/tissues related to Subacute Thyroiditis:

33
Bone marrow, Whole blood, Liver, Lung, Thyroid, Salivary gland, T cells, B cells, Temporal lobe, Pituitary

Animal Models for Subacute Thyroiditis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Subacute Thyroiditis

Sources:
51PubMed
See all sources

Articles related to Subacute Thyroiditis:

(show top 50)    (show all 356)
idTitleAuthorsYear
1
Visual vignette. Subacute thyroiditis. (23425654)
2013
2
Apathetic thyrotoxicosis secondary to atypical subacute thyroiditis. (22548945)
2012
3
What might cause pain in the thyroid gland? Report of a patient with subacute thyroiditis of atypical presentation. (22538753)
2012
4
Cytopathology of subacute thyroiditis. (22045514)
2012
5
Subacute thyroiditis presenting as a focal lesion on [18F] fluorodeoxyglucose whole-body positron-emission tomography/CT. (20299440)
2011
6
Subacute thyroiditis presenting as fever of unknown origin. (17956558)
2010
7
Subacute thyroiditis: clinical characteristics and treatment outcome in fifty-six consecutive patients diagnosed between 1999 and 2005. (17923793)
2007
8
Subacute thyroiditis following influenza vaccine (Vaxigrip) in a young female. (16793568)
2006
9
Coexistence of subacute thyroiditis and renal cell carcinoma: a paraneoplastic syndrome. (12695381)
2003
10
Atypical subacute thyroiditis: preliminary observations. (11484899)
2001
11
Subacute thyroiditis during treatment with combination therapy (interferon plus ribavirin) for hepatitis C virus. (10971829)
2000
12
Incomplete thyrotroph suppression determined by third generation thyrotropin assay in subacute thyroiditis compared to silent thyroiditis or hyperthyroid Graves' disease. (9024264)
1997
13
Subacute thyroiditis during interferon-alpha therapy for chronic hepatitis C. (9075068)
1997
14
The value of ultrasonography in the diagnosis and follow-up of subacute thyroiditis. (9086570)
1997
15
Pertechnetate thyroid uptake is not always suppressed in patients with subacute thyroiditis. (9031769)
1997
16
Dissociation between serum interleukin-6 rise and other parameters of disease activity in subacute thyroiditis during treatment with corticosteroid. (8636270)
1996
17
Graves' disease occurring after subacute thyroiditis: report of a case and review of the literature. (8875758)
1996
18
Subacute thyroiditis associated with interferon-alpha 2a therapy. (7729795)
1995
19
Effect of thyrotropin-releasing hormone on serum thyroid hormones: a study in the patients with untreated and treated Graves' disease and subacute thyroiditis. (7608274)
1995
20
Acute spontaneous hemorrhagic degeneration of the thyroid nodule with subacute thyroiditis-like symptoms and laboratory findings. (8574293)
1995
21
Painful subacute thyroiditis (de Quervain's thyroiditis). (1404465)
1992
22
Erythrocyte carbonic anhydrase-I concentrations in patients with Graves' disease and subacute thyroiditis reflect integrated thyroid hormone levels over the previous few months. (1899425)
1991
23
Susceptibility to subacute thyroiditis is genetically influenced: familial occurrence in identical twins. (1822362)
1991
24
Liver enzyme abnormalities in subacute thyroiditis. (1981099)
1990
25
Subacute thyroiditis: a review of 105 cases. (2743695)
1989
26
Recurrence of subacute thyroiditis over 10 years after the first attack in three cases. (3250859)
1988
27
Thyrotoxicosis, subacute thyroiditis and thyroid pain in Ireland. (3557923)
1987
28
Sweet's syndrome and subacute thyroiditis. (3803672)
1987
29
Late hypothyroidism following subacute thyroiditis. (3743646)
1986
30
Alkaline phosphatase activity in subacute thyroiditis and hyperthyroidism. (6862869)
1983
31
Recurrent subacute thyroiditis: a report of three cases. (6577333)
1983
32
Nature of thyrotropin displacement activity in subacute thyroiditis. (6274901)
1982
33
Evolution of thyroid 127I stores measured by X-ray fluorescence in subacute thyroiditis. (7054213)
1982
34
Alteration of thyroid function in the early stage of subacute thyroiditis. (6779475)
1980
35
Permissive role of thyrotropin on thyroid radioiodine uptake during the recovery phase of subacute thyroiditis. (834155)
1977
36
Morphological, cytological and biological observations on viruses isolated from patients with subacute thyroiditis de Quervain. (9797)
1976
37
Ultrastructure of the giant cell in de Quervain's subacute thyroiditis. (1274575)
1976
38
Sequential study of the impairment of thyroid function in the early stage of subacute thyroiditis. (4137186)
1974
39
Serum thyrotrophin response to thyrotrophin releasing hormone and the concentration of free thyroxine in subacute thyroiditis. (4128225)
1973
40
Occult subacute thyroiditis--diagnostic challenge. (5118969)
1971
41
Subacute thyroiditis--difficulties in diagnosis and treatment. (13743362)
1961
42
Subacute thyroiditis of De Quervain]. (13855111)
1960
43
SUBACUTE thyroiditis. (13627418)
1959
44
Thyroid function and the metabolism of iodine in patients with subacute thyroiditis. (13497335)
1958
45
The chronology of events in the development of subacute thyroiditis, studied by radioactive iodine. (13481090)
1957
46
Mumps virus and subacute thyroiditis; evidence of a causal association. (13429875)
1957
47
Subacute thyroiditis, struma lymphomatosa (Hashimoto's disease), and chronic fibrous invasive goitre (Riedel's disease); a clinical study based on a 20-year series of 83 cases. (13410449)
1957
48
Radioactive iodine uptake and localization studies with a scintiscanner in subacute thyroiditis. (13322295)
1956
49
Cortisone versus x-ray in the treatment of subacute thyroiditis: a report of four cases. (13327797)
1956
50
Subacute thyroiditis; report of two cases. (14361453)
1955

Genetic Variations for Subacute Thyroiditis

Expression for genes affiliated with Subacute Thyroiditis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Subacute Thyroiditis

Search GEO for disease gene expression data for Subacute Thyroiditis.

Pathways for genes affiliated with Subacute Thyroiditis

Sources:
38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 53R&D Systems, 12EMD Millipore, 60Tocris Bioscience, 54Reactome
See all sources

Pathways related to Subacute Thyroiditis according to GeneCards/GeneDecks:

(show all 50)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.3IL1R1
2
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10.3IL2RA
3
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10.3IL2RA
410.2TGFB1
510.2IL1B
6
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.1IFNG
710.1IL1R1, IL2RA
8
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10.1TPO, TG
9
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10.0EGF, IL2RA
10
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9.8IL2RA, IL1R1, TGFB1
11
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9.8TPO, TG, TGFB1
12
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9.7TPO, IL2RA, EGF
13
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9.7IL2RA, IL1R1, IL1B
14
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9.7IL1RN, IL1R1, IL1B
15
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9.7IL2RA, FGF2, EGF
169.6IFNG, IL2RA, TGFB1
17
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9.6IL1R1, IL1B, IL6
189.6IFNG, ICAM1, IL1B
19
Immune response IFN gamma signaling pathway
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9.6IL1B, ICAM1, IFNG
20
Cytokine production by Th17 cells in CF (Mouse model)
9.5TGFB1, IL6, ICAM1
219.5IFNG, EGF, TGFB1
229.5IFNG, ICAM1, IL6
239.4IL6, IL1B, IFNG
249.4IL6, IL1B, IFNG
259.4TGFB1, IL1R1, FGF2, EGF
26
Hide members
9.4EGF, BAK1, FGF2
27
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9.4IFNG, IL2RA, IL1R1, IL1B
289.3IFNG, IL1R1, IL1B, TGFB1
299.3TPO, IL6, IL2RA, IFNG
30
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9.2IFNG, IL1R1, IL1B, IL6
319.2IL6, IL1B, ICAM1, IFNG
329.2IFNG, EGF, IL6, TGFB1
33
Development PDGF signaling via STATs and NF-kB
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9.2IL6, IL1B, FGF2, IFNG
34
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9.1TGFB1, IL6, IL1B, IFNG
359.1IL2RA, IL1R1, IL1B, IL6, TPO
36
Hide members
9.1IL2RA, IL1RN, IL1R1, IL1B, IL6
37
Hide members
9.1IFNG, EGF, IL2RA, IL1R1, IL1B
389.1BGLAP, ICAM1, TGFB1
399.0TGFB1, IL6, IL1B, IL1R1, ICAM1
40
Immune response Bacterial infections in normal airways
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9.0IFNG, IL1RN, IL1R1, IL1B, IL6
41
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9.0IFNG, ICAM1, IL2RA, IL1B, IL6
42
Hide members
9.0IFNG, ICAM1, IL2RA, IL1B, IL6
438.9IFNG, IL1R1, IL1B, IL6, TGFB1
44
Hide members
8.9TGFB1, IL6, IL1B, IL1R1, IFNG
45
Hide members
8.7BAK1, FGF2, IL1B, IL6, TGFB1
468.7IL6, ICAM1, IFNG, BGLAP
478.6IFNG, ICAM1, IL1B, IL6, GGT1
48
Hide members
8.5IFNG, ICAM1, IL2RA, IL1RN, IL1R1, IL1B
49
Hide members
8.5EGF, FGF2, IL2RA, IL1R1, IL1B, IL6
50
Hide members
8.0IFNG, ICAM1, EGF, FGF2, IL2RA, IL1RN

Compounds for genes affiliated with Subacute Thyroiditis

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 2BitterDB, 24HMDB
See all sources

Compounds related to Subacute Thyroiditis according to GeneCards/GeneDecks:

(show top 50)    (show all 212)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6TG
2pge24510.6TGFB1
3pirfenidone45 6011.5IL1B
4cuprophan4510.1ICAM1, IL2RA, IL1R1
5gm-csf45 2911.0IFNG, ICAM1
6polysaccharide459.9TG, TPO, IL2RA, SHBG
7indomethacin45 60 29 1112.9GGT1, IL1R1, CA1
8ivig459.9IFNG, IL1RN, IL1R1, TG
9pentoxifylline45 1110.7NAGLU, IL1RN, IL1R1, GGT1
10alginate459.4BGLAP, IL1RN
11gold sodium thiomalate459.4IFNG, NAGLU, IL1R1, IL2RA, IL1B, IL1RN
12sulfasalazine45 29 50 1112.4IL1B, ICAM1, IL1R1, IL1RN, IL2RA
13bucillamine459.3IL1B, IL6, FGF2, IFNG
14hydrocortisone45 2 60 1112.2BGLAP, SHBG, FGF2, TPO, TG
15carbimazole45 1110.2IL2RA, BGLAP, TPO, SHBG
16polymyxin b459.2IFNG, IL1RN, IL1B, IL6, ICAM1
17heparin45 29 11 2412.1BGLAP, IL1RN, IL1R1, IL2RA, NAGLU
18anakinra45 1110.0IL1RN, IL1R1, IL1B, IL6
19prednisolone45 29 1111.0SHBG, FGF2, IL2RA, IL1R1, BGLAP, TG
20etanercept45 50 1111.0IL6, IL1R1, IL1RN, IFNG, IL1B
21thalidomide45 50 60 1112.0IL1B, IL1R1, IL2RA, FGF2, IL6, IFNG
22vitamin d459.0IL6, IL1R1, IL2RA, NAGLU, BGLAP
23il 10458.9IL1RN, IFNG, IL1R1, IL1B, TGFB1, IL6
24rantes458.8IL6, IL1B, IL1R1, IL2RA, ICAM1, IFNG
25neopterin458.8ICAM1, IL1B, IL1R1, IL1RN, IL6, NAGLU
26herbimycin a45 609.7IL6, IFNG, FGF2, IL2RA, IL1B, ICAM1
27methimazole45 2 1110.7BGLAP, TG, ICAM1, IL2RA, TPO
28ns 39845 609.6FGF2, IL1RN, BGLAP, IL1B, TGFB1
29cyclosporin a45 29 6010.4FGF2, IL2RA, TG, IL1R1, NAGLU, ICAM1
30methotrexate45 50 1110.4NAGLU, TGFB1, IL6, IL1B, IL1R1, IL1RN
31lactate458.2TG, TGFB1, IL1R1, IL1RN, NAGLU, SHBG
32thymidine45 249.2FGF2, IFNG, EGF, NAGLU, TGFB1, IL2RA
33genistein45 29 60 2 11 2413.2IL2RA, IL6, TPO, IL1B, FGF2, SHBG
34thyroxine45 249.1BGLAP, SHBG, FGF2, GGT1, TPO, TG
35hyaluronic acid45 249.1GGT1, IL1B, IL1R1, IL1RN, NAGLU, ICAM1
36creatinine458.1TGFB1, TG, TPO, GGT1, IL1RN, NAGLU
37actinomycin d458.0EGF, IL1R1, IL1B, ICAM1, TGFB1, IL6
38histamine45 29 249.9BGLAP, IL1RN, ICAM1, IL1B, IL6, TGFB1
39h2o2457.7BGLAP, ICAM1, FGF2, IL1RN, IL1R1, IL2RA
40ascorbic acid45 248.6SHBG, ICAM1, IL1R1, IL2RA, IL1RN, BGLAP
41infliximab45 50 119.6IFNG, IL1R1, IL1B, IL6, BAK1, FGF2
42dexamethasone45 50 29 1110.6BGLAP, SHBG, BAK1, FGF2, IL6, GGT1
43sb 20358045 608.5IFNG, BGLAP, EGF, FGF2, ICAM1, IL1B
44cisplatin45 50 60 1110.5NAGLU, BAK1, EGF, BGLAP, IL2RA, IL1R1
45testosterone45 60 11 2410.4IL1RN, IL2RA, SHBG, EGF, IL1R1, IL6
46calcitriol45 60 11 2410.1TGFB1, TG, IL6, BGLAP, IFNG, EGF
47vegf457.0IL1R1, IFNG, EGF, BGLAP, FGF2, IL2RA
48cysteine456.9IL2RA, BAK1, IL1R1, GGT1, TPO, EGF
49alanine456.9BGLAP, NAGLU, TG, GGT1, IL6, SHBG
50retinoic acid45 247.3SHBG, FGF2, BAK1, TG, BGLAP, IFNG

GO Terms for genes affiliated with Subacute Thyroiditis

Sources:
16Gene Ontology
See all sources

Cellular components related to Subacute Thyroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3IL6, IL2RA, ICAM1, IFNG
2extracellular spaceGO:0056157.0TGFB1, BGLAP, IFNG, ICAM1, EGF, FGF2
3extracellular regionGO:0055766.9BGLAP, IFNG, EGF, SHBG, FGF2, IL1R1

Biological processes related to Subacute Thyroiditis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cerebellar granule cell precursor proliferationGO:02194010.2EGF, FGF2
2positive regulation of calcidiol 1-monooxygenase activityGO:06055910.1IFNG, IL1B
3neutrophil apoptotic processGO:00178110.0IFNG, IL6
4positive regulation of interleukin-6 biosynthetic processGO:04541010.0IL1B, IFNG
5negative regulation of immune responseGO:0507779.9TGFB1, IL2RA
6positive regulation of chemokine biosynthetic processGO:0450809.8IL1B, IFNG
7positive regulation of cell divisionGO:0517819.8TGFB1, IL1B, FGF2
8positive regulation of T cell proliferationGO:0421029.7IFNG, IL1B, IL6
9positive regulation of NF-kappaB transcription factor activityGO:0510929.5ICAM1, IL1B, IL6, TGFB1
10positive regulation of nitric oxide biosynthetic processGO:0454299.5IL6, IL1B, ICAM1, IFNG
11cytokine-mediated signaling pathwayGO:0192219.3IFNG, ICAM1, IL1B, IL6
12response to glucocorticoid stimulusGO:0513849.2IL6, IL1RN, BGLAP
13positive regulation of apoptotic processGO:0430659.1TGFB1, IL6, IL2RA, BAK1
14positive regulation of transcription, DNA-dependentGO:0458939.0EGF, FGF2, IL1B, IL6, TGFB1
15negative regulation of cell proliferationGO:0082858.9TGFB1, IL6, IL1B, FGF2, BAK1
16response to ethanolGO:0454718.6BGLAP, ICAM1, BAK1
17response to drugGO:0424937.9TGFB1, BGLAP, IFNG, ICAM1, BAK1, IL1RN

Molecular functions related to Subacute Thyroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.2IL6, IL1B, FGF2, IFNG
2growth factor activityGO:0080839.0TGFB1, IL6, FGF2, EGF

Products for genes affiliated with Subacute Thyroiditis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Subacute Thyroiditis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet