MCID: SBC025
MIFTS: 18

Subcortical Arteriosclerotic Encephalopathy

Aliases & Classifications for Subcortical Arteriosclerotic Encephalopathy

MalaCards integrated aliases for Subcortical Arteriosclerotic Encephalopathy:

Name: Subcortical Arteriosclerotic Encephalopathy 50
Binswanger Disease 69

External Ids:

UMLS 69 C0270786

Summaries for Subcortical Arteriosclerotic Encephalopathy

NINDS : 50 Binswanger's disease (BD), also called subcortical vascular dementia, is a type of dementia caused by widespread, microscopic areas of damage to the deep layers of white matter in the brain. The damage is the result of the thickening and narrowing (atherosclerosis) of arteries that feed the subcortical areas of the brain. Atherosclerosis (commonly known as "hardening of the arteries") is a systemic process that affects blood vessels throughout the body. It begins late in the fourth decade of life and increases in severity with age. As the arteries become more and more narrowed, the blood supplied by those arteries decreases and brain tissue dies. A characteristic pattern of BD-damaged brain tissue can be seen with modern brain imaging techniques such as CT scans or magnetic resonance imaging (MRI). The symptoms associated with BD are related to the disruption of subcortical neural circuits that control what neuroscientists callexecutive cognitive functioning: short-term memory, organization, mood, the regulation of attention, the ability to act or make decisions, and appropriate behavior. The most characteristic feature of BD is psychomotor slowness - an increase in the length of time it takes, for example, for the fingers to turn the thought of a letter into the shape of a letter on a piece of paper. Other symptoms include forgetfulness (but not as severe as the forgetfulness of Alzheimer's disease), changes in speech, an unsteady gait, clumsiness or frequent falls, changes in personality or mood (most likely in the form of apathy, irritability, and depression), and urinary symptoms that aren't caused by urological disease. Brain imaging, which reveals the characteristic brain lesions of BD, is essential for a positive diagnosis.  

MalaCards based summary : Subcortical Arteriosclerotic Encephalopathy, also known as binswanger disease, is related to binswanger's disease and encephalopathy. An important gene associated with Subcortical Arteriosclerotic Encephalopathy is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways is Neuroscience. Affiliated tissues include brain, endothelial and smooth muscle.

Wikipedia : 72 Binswanger\'s disease, also known as subcortical leukoencephalopathy, is a form of small vessel vascular... more...

Related Diseases for Subcortical Arteriosclerotic Encephalopathy

Diseases related to Subcortical Arteriosclerotic Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 binswanger's disease 30.4 GFAP VIP
2 encephalopathy 10.9
3 cerebritis 10.4
4 hydrocephalus, normal-pressure 10.2
5 hydrocephalus 10.2
6 dementia 10.2
7 cerebral amyloid angiopathy, cst3-related 10.2
8 endotheliitis 10.0
9 blood group, i system 10.0
10 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 10.0
11 multiple sclerosis 10.0
12 ataxia and polyneuropathy, adult-onset 10.0
13 aceruloplasminemia 10.0
14 ataxia-oculomotor apraxia 3 10.0
15 parametritis 10.0
16 fetal alcohol syndrome 9.5 GFAP VIP
17 ganglioneuroma 9.4 GFAP VIP

Graphical network of the top 20 diseases related to Subcortical Arteriosclerotic Encephalopathy:



Diseases related to Subcortical Arteriosclerotic Encephalopathy

Symptoms & Phenotypes for Subcortical Arteriosclerotic Encephalopathy

Drugs & Therapeutics for Subcortical Arteriosclerotic Encephalopathy

Search Clinical Trials , NIH Clinical Center for Subcortical Arteriosclerotic Encephalopathy

Genetic Tests for Subcortical Arteriosclerotic Encephalopathy

Anatomical Context for Subcortical Arteriosclerotic Encephalopathy

MalaCards organs/tissues related to Subcortical Arteriosclerotic Encephalopathy:

38
Brain, Endothelial, Smooth Muscle

Publications for Subcortical Arteriosclerotic Encephalopathy

Articles related to Subcortical Arteriosclerotic Encephalopathy:

(show top 50) (show all 52)
# Title Authors Year
1
Elevated CNS concentrations of NFL in idiopathic normal pressure hydrocephalus (INPH) and subcortical arteriosclerotic encephalopathy (SAE). ( 18307570 )
2008
2
Regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE). ( 17340101 )
2007
3
Differentiation of multiple sclerosis plaques, subacute cerebral ischaemic infarcts, focal vasogenic oedema and lesions of subcortical arteriosclerotic encephalopathy using magnetisation transfer measurements. ( 12700877 )
2003
4
Differential lesion patterns in CADASIL and sporadic subcortical arteriosclerotic encephalopathy: MR imaging study with statistical parametric group comparison. ( 11161160 )
2001
5
Psychotic depression, subcortical arteriosclerotic encephalopathy and holocaust-conditioned posttraumatic stress disorder. ( 11270447 )
2001
6
CSF sulfatide distinguishes between normal pressure hydrocephalus and subcortical arteriosclerotic encephalopathy. ( 10864607 )
2000
7
Comparative analysis of gait in Parkinson's disease, cerebellar ataxia and subcortical arteriosclerotic encephalopathy. ( 10388800 )
1999
8
Increased coagulatory activity in subcortical arteriosclerotic encephalopathy (Binswanger's disease) ( 9987717 )
1999
9
1H-MRS differentiates white matter hyperintensities in subcortical arteriosclerotic encephalopathy from those in normal elderly. ( 9341699 )
1997
10
The angiopathy of subcortical arteriosclerotic encephalopathy (Binswanger's disease): immunohistochemical studies using markers for components of extracellular matrix, smooth muscle actin and endothelial cells. ( 9083552 )
1997
11
Parkinsonism due to Binswanger's subcortical arteriosclerotic encephalopathy. ( 8813238 )
1996
12
Occurrence of paroxysmal synchronous EEG discharges in subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 8329820 )
1993
13
Regional cerebral blood flow measured with I-123 IMP SPECT in a case of subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 1424377 )
1992
14
Amyloid beta-protein in cerebral amyloid angiopathy, senile plaques, and preamyloidotic lesions in subcortical arteriosclerotic encephalopathy (Binswanger disease). ( 1857541 )
1991
15
Evaluation of dementia in subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 1834189 )
1991
16
Subcortical arteriosclerotic encephalopathy: single photon emission computed tomography-magnetic resonance imaging correlation. ( 2252606 )
1990
17
Binswanger's disease (Part II): Pathogenesis of subcortical arteriosclerotic encephalopathy and its relation to other dementing processes. ( 2699555 )
1989
18
The value of T1-weighted images in the differentiation between MS, white matter lesions, and subcortical arteriosclerotic encephalopathy (SAE). ( 2674767 )
1989
19
Binswanger's disease (Part I): The clinical recognition of subcortical arteriosclerotic encephalopathy in elderly neuropsychiatric patients. ( 2686675 )
1989
20
Pathological findings correlated with magnetic resonance imaging in subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 2614428 )
1989
21
Subcortical arteriosclerotic encephalopathy--a controlled psychometric study. ( 2548788 )
1989
22
Subcortical arteriosclerotic encephalopathy: a clinical and radionuclide brain scintiscan study. ( 3407386 )
1988
23
Computerized tomographic findings and differential diagnostic considerations in subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 3179978 )
1988
24
Alterations of short-latency somatosensory evoked potentials in subcortical arteriosclerotic encephalopathy (Binswanger's Disease): a preliminary report. ( 3191878 )
1988
25
Cerebral amyloid angiopathy with attenuation of the white matter on CT scans: subcortical arteriosclerotic encephalopathy (Binswanger) in a normotensive patient. ( 3221249 )
1988
26
Effects of enzymatic blood defibrination in subcortical arteriosclerotic encephalopathy. ( 3063776 )
1988
27
Subcortical arteriosclerotic encephalopathy (Binswanger's disease): a report of five patients. ( 3618106 )
1987
28
Gait disorder of subcortical arteriosclerotic encephalopathy: Binswanger's disease. ( 3504256 )
1987
29
Subcortical arteriosclerotic encephalopathy: brain stem findings with MR imaging. ( 3685341 )
1987
30
Subcortical arteriosclerotic encephalopathy: Binswanger's disease. ( 3665181 )
1987
31
Subcortical arteriosclerotic encephalopathy (Binswanger's disease). Presentation of two cases. ( 3604757 )
1987
32
Subcortical arteriosclerotic encephalopathy (Binswanger's disease). Report of a case simulating psychiatric disease and normal pressure hydrocephalus. ( 3473291 )
1987
33
Expanding cerebellar lacunes due to dilatation of the perivascular space associated with Binswanger's subcortical arteriosclerotic encephalopathy. ( 3686582 )
1987
34
The role of plasma hyperviscosity in subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 3559641 )
1987
35
Mental changes in subcortical arteriosclerotic encephalopathy. ( 2439247 )
1987
36
High-resolution nuclear magnetic resonance imaging and single photon emission computerized tomography--cerebral blood flow in a case of pure sensory stroke and mild dementia owing to subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 3502532 )
1987
37
Subcortical arteriosclerotic encephalopathy: CT spectrum and pathologic correlation. ( 3490756 )
1986
38
Subcortical arteriosclerotic encephalopathy (Binswanger's disease). Computed tomographic, nuclear magnetic resonance, and clinical correlations. ( 4038102 )
1985
39
Hypoperfusion in the aetiology of subcortical arteriosclerotic encephalopathy (Binswanger type) ( 6747657 )
1984
40
Cerebrospinal fluid dynamics, white matter degeneration, and mental deterioration in subcortical arteriosclerotic encephalopathy of Binswanger type. ( 6738547 )
1984
41
Subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 6823631 )
1983
42
Subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 7151918 )
1982
43
Subcortical arteriosclerotic encephalopathy (Binswanger's type) and cortical infarcts in a young normotensive patient. ( 7086453 )
1982
44
Subcortical arteriosclerotic encephalopathy: a clinical and radiological investigation. ( 7241156 )
1981
45
Predominant white matter involvement in subcortical arteriosclerotic encephalopathy (Binswanger disease). ( 7354170 )
1980
46
Periodic EEG activity in subcortical arteriosclerotic encephalopathy (Binswanger's type). ( 508160 )
1979
47
Subcortical arteriosclerotic encephalopathy (Binswanger): computerized tomography. ( 572497 )
1979
48
Clinical features of subcortical arteriosclerotic encephalopathy (Binswanger disease). ( 569779 )
1978
49
Subcortical arteriosclerotic encephalopathy (Binswanger's disease). A vascular etiology of dementia. ( 1006740 )
1976
50
A case of subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 5068470 )
1972

Variations for Subcortical Arteriosclerotic Encephalopathy

Expression for Subcortical Arteriosclerotic Encephalopathy

Search GEO for disease gene expression data for Subcortical Arteriosclerotic Encephalopathy.

Pathways for Subcortical Arteriosclerotic Encephalopathy

Pathways related to Subcortical Arteriosclerotic Encephalopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.16 GFAP VIP

GO Terms for Subcortical Arteriosclerotic Encephalopathy

Sources for Subcortical Arteriosclerotic Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....