Subependymal Giant Cell Astrocytoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Subependymal Giant Cell Astrocytoma

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MalaCards: Subependymal Giant Cell Astrocytoma, also known as SEGA, is related to astrocytoma and tuberous sclerosis. An important gene associated with Subependymal Giant Cell Astrocytoma is TSC1 (tuberous sclerosis 1), and among its related pathways are Inhibition of TSC complex formation by PKB and mTOR signaling pathway. The compounds estrogen and streptozotocin have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and skin, and related mouse phenotypes are muscle and homeostasis/metabolism.

Aliases & Classifications for Subependymal Giant Cell Astrocytoma

Sources:
⁸Disease Ontology, ⁴²NIH Rare Diseases, ¹⁰DISEASES, ⁴⁸Orphanet, ⁶⁰UMLS, ⁴⁴Novoseek, ³⁹NCIt, ³⁴MeSH, ⁵⁶SNOMED-CT, ⁵⁷SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases

Aliases & Descriptions:

subependymal giant cell astrocytoma ⁸ ⁴² ¹⁰ ⁴⁸ ⁶⁰

sega ⁸ ⁴² ⁴⁸

astrocytoma subependymal giant cell ⁴⁴

External Ids:

Disease Ontology⁸ DOID:5077

NCIt³⁹ C3696

SNOMED-CT⁵⁶ 1586004

MeSH³⁴ D001254

SNOMED-CT via Orphanet⁵⁷ 449799008, 1586004

UMLS⁶⁰ C0205768

Related Diseases for Subependymal Giant Cell Astrocytoma

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases related to Subependymal Giant Cell Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 185)

id	Related Disease	Score	Top Affiliating Genes
1	astrocytoma	31.9	VIM, S100B, NES, SYP, MAP2, GFAP
2	tuberous sclerosis	31.7	VIM, S100B, NES, MTOR, SYP, MAP2
3	angiomyolipoma	30.8	VIM, MTOR, TSC1, TSC2
4	neuroblastoma	30.7	TP53, ENO2, SYP
5	giant cell glioblastoma	30.4	GFAP
6	gemistocytic astrocytoma	30.4	S100B, GFAP
7	central neurocytoma	30.4	SYP, MAP2, GFAP
8	multiple sclerosis	30.4	NPY, MAP2, GFAP
9	retinoblastoma	30.4	MTOR, SYP, MAP2, GFAP, ENO2, TP53
10	giant cell tumor	10.6
11	spinal cord astrocytoma	10.3
12	lymphedema	10.3
13	optic nerve astrocytoma	10.3
14	optic nerve glioma	10.3
15	subependymal glioma	10.3
16	perivascular epithelioid cell tumor	10.0	TSC2
17	kidney rhabdoid cancer	10.0	TSC2
18	dysembryoplastic neuroepithelial tumor	10.0	SYP
19	neuropathy	10.0	SGCA
20	melanotic neuroectodermal tumor	10.0	SYP
21	phaeochromocytoma	10.0	NPY
22	medulloepithelioma	10.0	SYP
23	gliosarcoma	10.0	GFAP
24	subependymoma	10.0	TSC2
25	pneumothorax	10.0	TSC1
26	down syndrome	10.0	S100B
27	hypertension	10.0	NPY
28	retinal detachment	10.0	GFAP
29	gliomatosis cerebri	10.0	GFAP
30	thymus cancer	10.0	SYP
31	constipation	10.0	CCK
32	histiocytosis	10.0	S100B
33	primary hyperoxaluria	10.0	MTOR
34	tuberous sclerosis complex	10.0	TSC2, TSC1
35	mixed glioma	10.0	GFAP
36	hydrocephalus	10.0	TSC1, NES
37	alcohol dependence	10.0	NPY
38	osteoarthritis	10.0	NPY
39	von hippel-lindau disease	10.0	TSC2, NPY
40	gastroesophageal reflux disease	10.0	CCK
41	lymphangioleiomyomatosis	10.0	TSC2, TSC1
42	pancreas disease	10.0	CCK
43	papilloma	10.0	TP53
44	osteosarcoma	10.0	TP53
45	endometrial carcinoma	10.0	TP53
46	encephalitis	10.0	CALB1, GFAP
47	adrenocortical carcinoma	10.0	TP53
48	colon cancer	10.0	TP53
49	hyperinsulinemic hypoglycemia	10.0	SST
50	cerebral primitive neuroectodermal tumor	10.0	ENO2

Graphical network of the top 20 diseases related to Subependymal Giant Cell Astrocytoma:

Clinical Features for Subependymal Giant Cell Astrocytoma

Drugs & Therapeutics for Subependymal Giant Cell Astrocytoma

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Subependymal Giant Cell Astrocytoma

Drug clinical trials:

Search ClinicalTrials for Subependymal Giant Cell Astrocytoma

Search NIH Clinical Center for Subependymal Giant Cell Astrocytoma

Search CenterWatch for Subependymal Giant Cell Astrocytoma

Genetic Tests for Subependymal Giant Cell Astrocytoma

Anatomical Context for Subependymal Giant Cell Astrocytoma

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³²MalaCards
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MalaCards organs/tissues related to Subependymal Giant Cell Astrocytoma:

³²

Brain, Spinal cord, Skin, Testes

Animal Models for Subependymal Giant Cell Astrocytoma or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Subependymal Giant Cell Astrocytoma:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle phenotype	MP:0005369	9.1	TP53, TSC1, SGCA, GFAP
2	homeostasis/metabolism phenotype	MP:0005376	8.3	CCK, NPY, FABP7, MTOR, GFAP, SGCA
3	no phenotypic analysis	MP:0003012	7.9	CCK, FABP7, MTOR, SYP, SST, TP53
4	normal phenotype	MP:0002873	7.6	S100B, NPY, MTOR, SYP, SST, GFAP
5	nervous system phenotype	MP:0003631	7.2	TSC1, CCK, CALB1, NPY, FABP7, SYP
6	growth/size phenotype	MP:0005378	6.7	VIM, NPY, NES, MTOR, SST, MAP2
7	behavior/neurological phenotype	MP:0005386	5.1	NES, FABP7, NPY, S100B, CALB1, VIM

Publications for Subependymal Giant Cell Astrocytoma

Sources:
⁵⁰PubMed
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Articles related to Subependymal Giant Cell Astrocytoma:

(show top 50) (show all 113)

id	Title	Authors	Year
1	Subependymal giant cell astrocytoma associated with tuberous sclerosis presenting with intratumoral bleeding. Case report and review of literature. (23138436)	Sterman H.... Teixeira M.J.	2013
2	Congenital Segmental Lymphedema in Tuberous Sclerosis Complex With Associated Subependymal Giant Cell Astrocytomas Treated with Mammalian Target of Rapamycin Inhibitors. (24056156)	Prato G.... GarrA" M.L.	2013
3	Everolimus in the treatment of subependymal giant cell astrocytomas, angiomyolipomas, and pulmonary and skin lesions associated with tuberous sclerosis complex. (24143074)	Franz D.N.	2013
4	Everolimus for the Treatment of Subependymal Giant Cell Astrocytoma Probably Causing Seizure Aggravation in a Child with Tuberous Sclerosis Complex: A Case Report. (24293099)	Wiemer-Kruel A.... Bast T.	2013
5	Subependymal giant cell astrocytoma: diagnosis, screening, and treatment. Recommendations from the International Tuberous Sclerosis Complex Consensus Conference 2012. (24138953)	Roth J.... Wang H.Z.	2013
6	The outcome of surgical management of subependymal giant cell astrocytoma in tuberous sclerosis complex. (23183057)	Amin S.... O'Callaghan F.J.	2013
7	Subependymal giant cell astrocytoma with atypical clinical and pathological features: aA diagnostic pitfall. (23641712)	Svajdler M.... FrAPhlichovA! L.	2013
8	Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial. (23158522)	Franz D.N.... Jozwiak S.	2013
9	Subependymal giant cell astrocytoma: Cytological findings. (23326038)	Azarpira N.... Rakei M.	2012
10	Squash cytology of subependymal giant cell astrocytoma: report of four cases with brief review of literature. (22431322)	Jaiswal S.... Behari S.	2012
11	Neurology: Letter to the editor. Re: Sun P, Kohrman M, Liu J et al. Outcomes of resecting subependymal giant cell astrocytoma (SEGA) among patients with SEGA-related tuberous sclerosis complex: a national claims database analysis. Curr Med Res Opin 2012;28:657-63. (22876836)	Berhouma M.... Messerer M.	2012
12	Effective everolimus treatment of inoperable, life-threatening subependymal giant cell astrocytoma and intractable epilepsy in a patient with tuberous sclerosis complex. (22000822)	Perek-Polnik M.... Kotulska K.	2012
13	Everolimus (RAD001): first systemic treatment for subependymal giant cell astrocytoma associated with tuberous sclerosis complex. (23231513)	JA^zwiak S.... Kotulska K.	2012
14	Potential of mTOR inhibitors for the treatment of subependymal giant cell astrocytomas in tuberous sclerosis complex. (21415462)	Major P.	2011
15	From the bench to the bedside: Everolimus for subependymal giant cell astrocytomas in Tuberous sclerosis complex, optic nerve regeneration, targeted cytotoxins for gliomas. (21297924)	Hauptman J.S.	2011
16	Hemorrhagic subependymal giant cell astrocytoma in a patient with tuberous sclerosis: case report and review of the literature. (22234227)	Wadhwa R.... Guthikonda B.	2011
17	Rapamycin as an alternative to surgical treatment of subependymal giant cell astrocytomas in a patient with tuberous sclerosis complex. (20887114)	Birca A.... Major P.	2010
18	Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. (21047224)	Krueger D.A.... Franz D.N.	2010
19	Subependymal giant cell astrocytoma (SEGA): Is it an astrocytoma? Morphological, immunohistochemical and ultrastructural study. (18564101)	Buccoliero A.M.... Taddei G.L.	2009
20	Fornix damage from solitary subependymal giant cell astrocytoma causing postoperative amnesic syndrome. (19684542)	Ibrahim I.... Larner A.J.	2009
21	Solitary subependymal giant cell astrocytoma incidentally found at autopsy in an elderly woman without tuberous sclerosis complex. (18673443)	Takei H.... Powell S.Z.	2009
22	Subependymal nodules, giant cell astrocytomas and the tuberous sclerosis complex: a population-based study. (18456692)	O'Callaghan F.J.... Osborne J.P.	2008
23	Neonatal subependymal giant cell astrocytoma: new case and review of literature. (17275668)	Raju G.P.... Sahin M.	2007
24	Upregulation of the WNT pathway in tuberous sclerosis-associated subependymal giant cell astrocytomas. (17071037)	Jozwiak J.... Wlodarski P.	2007
25	Cytologic characteristics of subependymal giant cell astrocytoma in squash smears: morphometric comparisons with gemistocytic astrocytoma and giant cell glioblastoma. (17536538)	Kim S.H.... Kim T.S.	2007
26	Subependymal giant cell astrocytoma with high choline/creatine ratio on proton MR spectroscopy. (17057903)	de Carvalho Neto A.... Bruck I.	2006
27	Developmental origin of subependymal giant cell astrocytoma in tuberous sclerosis complex. (15851742)	Ess K.C.... Gutmann D.H.	2005
28	Subependymal giant cell astrocytoma and concordant expression in a disease of variable penetrance. (16041550)	Dickerman R.D.... Cohen A.	2005
29	Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation. (15624760)	Chan J.A.... Kwiatkowski D.J.	2004
30	Tuberin and hamartin expression is reduced in the majority of subependymal giant cell astrocytomas in tuberous sclerosis complex consistent with a two-hit model of pathogenesis. (15072102)	JA^A_wiak S.... Roszkowski M.	2004
31	Subependymal giant cell astrocytoma--a clinicopathological study of 23 cases with special emphasis on histogenesis. (15619643)	Sharma M.C.... Sarkar C.	2004
32	Subependymal giant cell astrocytoma: a report of five cases. (15309659)	Kumar R.... Singh V.	2004
33	Subependymal giant cell astrocytoma in children with tuberous sclerosis. (12715190)	Cuccia V.... Taratuto A.L.	2003
34	Rapid regrowth of solitary subependymal giant cell astrocytoma--case report. (12064158)	Yamamoto K.... Ushio Y.	2002
35	Neonatal subependymal giant cell astrocytoma. (12053047)	Medhkour A.... Husain M.	2002
36	Subependymal giant cell astrocytoma associated with tuberous sclerosis exhibiting rapid regrowth after 17 years: a case report]. (10396738)	Kawasaki S.... Ohtsuki Y.	1999
37	Image interpretation session: 1998. Tuberous sclerosis with multiple bilateral renal cysts and a subependymal giant cell astrocytoma. (10722364)		1999
38	Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors. (9403714)	Henske E.P.... Yeung R.S.	1997
39	Subependymal giant cell astrocytoma associated with tuberous sclerosis: diagnostic and surgical characteristics of five cases with unusual features. (8884092)	Turgut M.... Erbengi A.	1996
40	Residents' corner. Answer to case of the month #35. Bilateral subependymal giant cell astrocytoma associated with tuberous sclerosis. (8548472)	Garant M.... Duong H.	1996
41	Hemorrhagic subependymal giant cell astrocytoma. (7761172)	Kalina P.... Hyman R.A.	1995
42	A neonatal huge subependymal giant cell astrocytoma: case report. (7808622)	Oikawa S.... Kobayashi N.	1994
43	Cytomorphology of subependymal giant cell astrocytoma. A case report. (8465641)	Ahluwalia C.K.... Chandrasoma P.T.	1993
44	Cytomorphology of subependymal giant cell astrocytoma. (1543002)	Altermatt H.J.... Scheithauer B.W.	1992
45	Rare subependymal giant-cell astrocytoma in a neonate with tuberous sclerosis. (2124070)	Tien R.D.... Duberg A.	1990
46	Subependymal giant cell astrocytoma associated with tuberous sclerosis: with special reference to cell kinetic studies--case report. (1708461)	Nishizaki T.... Ito H.	1990
47	Subependymal giant-cell astrocytoma. A case report. (3218563)	Gangemi M.... Insabato L.	1988
48	Sequential CT study of subependymal giant-cell astrocytoma associated with tuberous sclerosis. Case report. (3772487)	Morimoto K.... Mogami H.	1986
49	Neuroblastoma, tuberous sclerosis, and subependymal giant cell astrocytoma. (6614397)	Miller D.R.... Horten B.	1983
50	Subependymal giant-cell astrocytoma. Case report with ultrastructural study. (430139)	Sima A.A.... Robertson D.M.	1979

Genes related to Subependymal Giant Cell Astrocytoma

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Subependymal Giant Cell Astrocytoma:

(show all 17)

id	Symbol	Description	Score	Implication
1	TSC1	tuberous sclerosis 1	20.62	GeneCards inferred : Publications, Disorders (show sections)
2	TSC2	tuberous sclerosis 2	19.45	GeneCards inferred : Publications, Disorders (show sections)
3	FABP7	fatty acid binding protein 7, brain	18.27	GeneCards inferred : Publications, Disorders (show sections)
4	NES	nestin	17.09	GeneCards inferred : Publications, Disorders (show sections)
5	SGCA	sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)	15.92	GeneCards inferred : Disorders (show sections)
6	SYP	synaptophysin	14.74	GeneCards inferred : Publications, Disorders (show sections)
7	NPY	neuropeptide Y	13.56	GeneCards inferred : Publications, Disorders (show sections)
8	GFAP	glial fibrillary acidic protein	12.39	GeneCards inferred : Publications, Disorders (show sections)
9	S100B	S100 calcium binding protein B	11.21	GeneCards inferred : Publications, Disorders (show sections)
10	CCK	cholecystokinin	10.03	GeneCards inferred : Publications, Disorders (show sections)
11	MTOR	mechanistic target of rapamycin (serine/threonine kinase)	8.86	GeneCards inferred : Publications, Disorders (show sections)
12	MAP2	microtubule-associated protein 2	7.68	GeneCards inferred : Publications, Disorders (show sections)
13	SST	somatostatin	6.51	GeneCards inferred : Publications, Disorders (show sections)
14	VIM	vimentin	5.33	GeneCards inferred : Publications, Disorders (show sections)
15	TP53	tumor protein p53	4.15	GeneCards inferred : Publications, Disorders (show sections)
16	CALB1	calbindin 1, 28kDa	2.98	GeneCards inferred : Publications, Disorders (show sections)
17	ENO2	enolase 2 (gamma, neuronal)	1.80	GeneCards inferred : Disorders (show sections)

Products for genes related to Subependymal Giant Cell Astrocytoma disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	16	16	17
2	LSBio	-	-	17

Genetic Variations for Subependymal Giant Cell Astrocytoma

Expression for genes affiliated with Subependymal Giant Cell Astrocytoma

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Subependymal Giant Cell Astrocytoma

Search GEO for disease gene expression data for Subependymal Giant Cell Astrocytoma.

Pathways for genes affiliated with Subependymal Giant Cell Astrocytoma

Sources:
⁵³Reactome, ³⁷NCBI BioSystems Database, ⁵¹QIAGEN, ²⁹KEGG, ¹²EMD Millipore, ⁵²R&D Systems, ⁴Cell Signaling Technology
See all sources

Pathways related to Subependymal Giant Cell Astrocytoma according to GeneCards/GeneDecks:

(show all 20)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Inhibition of TSC complex formation by PKB⁵³	10.0	TSC2, TSC1
2	mTOR signaling pathway³⁷	9.7	MTOR, TSC1, TSC2
3	IRS-related events⁵³ Hide members IRS-mediated signalling⁵³ IRS-related events triggered by IGF1R⁵³ Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)⁵³ IGF1R signaling cascade⁵³ Signaling by Insulin receptor⁵³ Insulin receptor signalling cascade⁵³ PI3K Cascade⁵³	9.7	MTOR, TSC1, TSC2
4	Energy dependent regulation of mTOR by LKB1-AMPK⁵³ Hide members PKB-mediated events⁵³ Regulation of Rheb GTPase activity by AMPK⁵³ TOR signaling³⁷ mTOR signalling⁵³	9.7	MTOR, TSC1, TSC2
5	Glioblastoma Multiforme⁵¹	9.4	TP53, TSC2, TSC1
6	PIP3 activates AKT signaling⁵³ Hide members PI-3K cascade⁵³ Signaling by SCF-KIT⁵³ PI3K events in ERBB2 signaling⁵³ PI3K events in ERBB4 signaling⁵³ Signaling by ERBB4⁵³ GAB1 signalosome⁵³ PI3K/AKT Signaling in Cancer⁵³ Constitutive PI3K/AKT Signaling in Cancer⁵³ PI3K/AKT activation⁵³	9.3	TSC2, GFAP, MTOR, S100B
7	Endometrial cancer²⁹ Hide members Colorectal cancer²⁹ Signal transduction PTEN pathway¹² Acute myeloid leukemia²⁹	9.3	TP53, TSC2, MTOR
8	G-protein signaling Ras family GTPases in kinase cascades (scheme) Hide members MAPK Cascade³⁷ Oncostatin M Signaling Pathway³⁷	9.1	MTOR, MAP2, TP53
9	Glioma²⁹ Hide members Non-small cell lung cancer²⁹ Prostate cancer²⁹ Signaling Pathways in Glioblastoma³⁷	9.0	TP53, TSC2, TSC1, MTOR
10	AMPK signaling³⁷	9.0	TP53, TSC2, TSC1, MTOR
11	Development IGF-RI signaling¹² Hide members Signal transduction AKT signaling¹²	9.0	TP53, TSC2, TSC1, MTOR
12	PI3K-Akt signaling pathway²⁹	9.0	TP53, TSC2, TSC1, MTOR
13	Integrated Breast Cancer Pathway³⁷	9.0	TP53, TSC2, TSC1, MTOR
14	Akt Signaling Pathway ⁵²	9.0	MTOR, TSC1, TSC2, TP53
15	Prostate Cancer³⁷	9.0	MTOR, TSC1, TSC2, TP53
16	Spinal Cord Injury³⁷	9.0	TP53, GFAP, VIM
17	Cytoskeleton remodeling Neurofilaments¹² Hide members Cytoplasmic microtubules¹²	9.0	VIM, NES, MAP2, GFAP
18	LKB1 signaling events³⁷	8.6	MTOR, MAP2, TSC1, TSC2, TP53
19	Signaling by GPCR⁵³ Hide members Signal Transduction⁵³ GPCR downstream signaling⁵³ Signal Transduction⁵³	8.0	CCK, S100B, NPY, MTOR, SST, GFAP
20	Neuroscience⁴	7.3	ENO2, CALB1, S100B, NPY, FABP7, SYP

Compounds for genes affiliated with Subependymal Giant Cell Astrocytoma

Sources:
⁴⁴Novoseek, ²⁸IUPHAR, ¹¹DrugBank, ⁴⁹PharmGKB, ⁵⁹Tocris Bioscience, ²⁴HMDB
See all sources

Compounds related to Subependymal Giant Cell Astrocytoma according to GeneCards/GeneDecks:

(show top 50) (show all 124)

id	Compound	Score	Top Affiliating Genes
1	estrogen⁴⁴	10.2	MAP2, GFAP
2	streptozotocin⁴⁴	9.6	NES, GFAP, SYP, SST
3	creatinine⁴⁴	9.6	SGCA, GFAP, SYP, NPY
4	eosin⁴⁴	9.4	VIM, GFAP, S100B
5	reticulin⁴⁴	9.4	S100B, VIM, SYP, GFAP
6	nmda⁴⁴ ²⁸	10.3	VIM, SYP, GFAP, MAP2
7	n-acetylaspartate⁴⁴	9.2	CALB1, SYP, GFAP
8	spec-t⁴⁴	9.1	ENO2, SST, GFAP, TSC1
9	bethanechol⁴⁴ ²⁸ ¹¹	11.1	SST, NPY, CCK
10	dmso⁴⁴	9.0	ENO2, MAP2, NES, NPY
11	s 100⁴⁴	9.0	ENO2, GFAP, SYP, S100B, VIM
12	glutamate⁴⁴	8.9	CCK, CALB1, NPY, FABP7, GFAP
13	forskolin⁴⁴ ⁴⁹ ¹¹	10.9	NPY, CCK, GFAP, ENO2, VIM
14	catecholamine⁴⁴	8.8	VIM, S100B, NPY, SYP, ENO2
15	methamphetamine⁴⁴ ⁴⁹ ¹¹	10.7	GFAP, MAP2, NPY, CALB1
16	cocaine⁴⁴ ¹¹	9.6	NPY, MAP2, S100B, CCK, VIM, GFAP
17	ganglioside⁴⁴	8.6	NES, SYP, MAP2, VIM, GFAP, ENO2
18	hematoxylin⁴⁴	8.5	MAP2, GFAP, VIM, SYP, S100B, ENO2
19	dbc-amp⁴⁴	8.5	GFAP, MAP2, SYP, S100B, VIM, ENO2
20	tetrodotoxin⁴⁴ ⁵⁹ ²⁸	10.5	GFAP, ENO2, CALB1, NPY, CCK
21	kainate⁴⁴ ²⁸	9.5	NPY, NES, SYP, MAP2, GFAP, CALB1
22	l-amino acid⁴⁴	8.5	ENO2, CALB1, S100B, SYP, MAP2
23	vinblastine⁴⁴ ⁴⁹ ¹¹	10.5	TP53, MAP2, SST, NPY, VIM
24	silver⁴⁴	8.4	ENO2, GFAP, MAP2, SYP, CALB1
25	acth⁴⁴	8.4	SYP, GFAP, SST, NPY, ENO2, S100B
26	glucose⁴⁴	8.3	CALB1, CCK, TSC2, TSC1, GFAP, MAP2
27	glutamine⁴⁴	8.2	NPY, S100B, CCK, SYP, GFAP, ENO2
28	leucine⁴⁴	8.1	VIM, SYP, ENO2, GFAP, S100B, TSC2
29	dopamine⁴⁴ ²⁸ ¹¹ ²⁴	11.0	ENO2, CCK, CALB1, NPY, NES, MAP2
30	acetylcholine⁴⁴ ⁴⁹ ²⁸ ¹¹ ²⁴	12.0	ENO2, SST, SYP, NES, CALB1, CCK
31	lactate⁴⁴	7.9	ENO2, S100B, NPY, SST, MAP2, VIM
32	formaldehyde⁴⁴ ²⁴	8.8	VIM, CALB1, NPY, SYP, ENO2, GFAP
33	bromodeoxyuridine⁴⁴	7.7	CALB1, ENO2, GFAP, MAP2, NES, S100B
34	glycogen⁴⁴ ²⁴	8.7	VIM, S100B, MTOR, SYP, MAP2, GFAP
35	potassium⁴⁴ ¹¹ ²⁴	9.7	GFAP, CALB1, S100B, SYP, MAP2, ENO2
36	lipid⁴⁴	7.7	GFAP, MTOR, SYP, ENO2, NES, TSC2
37	progesterone⁴⁴ ⁵⁹ ²⁸ ¹¹ ²⁴	11.6	GFAP, TP53, MAP2, SYP, NES, S100B
38	adenylate⁴⁴	7.5	S100B, GFAP, TSC2, ENO2, MAP2, SST
39	norepinephrine⁴⁴ ¹¹ ²⁴	9.4	CALB1, CCK, ENO2, MAP2, SYP, NPY
40	5-hydroxytryptamine⁴⁴	7.4	CCK, CALB1, SYP, VIM, NPY, SST
41	arginine⁴⁴	7.4	SST, TSC2, TP53, GFAP, MTOR, NPY
42	paraffin⁴⁴	7.0	SYP, NES, NPY, S100B, VIM, MAP2
43	atp⁴⁴ ²⁸	8.0	TSC2, VIM, CALB1, S100B, NPY, MTOR
44	dexamethasone⁴⁴ ⁴⁹ ²⁸ ¹¹	9.9	ENO2, SST, SYP, MTOR, S100B, CALB1
45	choline⁴⁴ ¹¹ ²⁴	8.8	ENO2, GFAP, MAP2, SST, SYP, NPY
46	tyrosine⁴⁴	6.5	MTOR, GFAP, ENO2, TSC1, TSC2, CCK
47	vegf⁴⁴	6.4	TSC1, NES, TP53, TSC2, SST, MAP2
48	gaba⁴⁴	6.2	ENO2, GFAP, MAP2, SST, SYP, NES
49	testosterone⁴⁴ ⁵⁹ ¹¹ ²⁴	9.1	TSC2, ENO2, GFAP, MAP2, SST, SYP
50	retinoic acid⁴⁴ ²⁴	6.2	GFAP, MTOR, SYP, SST, MAP2, ENO2

GO Terms for genes affiliated with Subependymal Giant Cell Astrocytoma

Sources:
¹⁶Gene Ontology
See all sources

Cellular components related to Subependymal Giant Cell Astrocytoma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	TSC1-TSC2 complex	GO:033596	10.0	TSC1, TSC2
2	intermediate filament	GO:005882	9.1	VIM, NES, GFAP
3	neuronal cell body	GO:043025	8.1	TSC2, MAP2, SST, FABP7, S100B, CALB1
4	cytosol	GO:005829	6.9	CALB1, MTOR, GFAP, ENO2, TSC1, TSC2
5	cytoplasm	GO:005737	6.7	VIM, S100B, FABP7, NES, MTOR, MAP2

Biological processes related to Subependymal Giant Cell Astrocytoma according to GeneCards/GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell size	GO:045792	9.9	TSC2, TSC1, MTOR
2	regulation of protein kinase activity	GO:045859	9.9	TSC1, MTOR
3	Bergmann glial cell differentiation	GO:060020	9.9	GFAP, VIM
4	astrocyte development	GO:014002	9.8	GFAP, VIM
5	intermediate filament organization	GO:045109	9.7	VIM, GFAP
6	positive regulation of protein oligomerization	GO:032461	9.6	TP53, CCK
7	axonogenesis	GO:007409	9.6	CCK, S100B, MAP2
8	central nervous system neuron development	GO:021954	9.5	MAP2, NPY
9	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.3	TP53, MTOR, CCK
10	cellular response to organic substance	GO:071310	9.2	MAP2, SYP, CALB1
11	cellular response to hypoxia	GO:071456	9.2	TP53, MTOR, S100B
12	central nervous system development	GO:007417	9.2	TP53, NES, S100B
13	negative regulation of cell proliferation	GO:008285	9.0	FABP7, SST, TSC1, TSC2, TP53

Products for genes affiliated with Subependymal Giant Cell Astrocytoma

Antibodies
Proteins
Lysates

Antibodies

Sources for Subependymal Giant Cell Astrocytoma

¹BioGPS

²BitterDB

³CDC

⁴Cell Signaling Technology

⁵CenterWatch

⁶ClinicalTrials

⁷dbSNP

⁸Disease Ontology

⁹diseasecard

¹⁰DISEASES

¹¹DrugBank

¹²EMD Millipore

¹³ExPASy

¹⁴FMA

¹⁵Gene Expression Omnibus DataSets

¹⁶Gene Ontology

¹⁷GeneCards

¹⁸GeneDecks

¹⁹GeneReviews

²⁰GeneTests

²¹Genetics Home Reference

²²GTR

²³HGMD

²⁴HMDB

²⁵ICD10

²⁶ICD10 via Orphanet

²⁷ICD9CM

²⁸IUPHAR

²⁹KEGG

³⁰LifeMap Discovery™

³¹LifeSpan BioSciences, Inc.

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PharmGKB

⁵⁰PubMed

⁵¹QIAGEN

⁵²R&D Systems

⁵³Reactome

⁵⁴SABiosciences

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸Thomson Reuters

⁵⁹Tocris Bioscience

⁶⁰UMLS

⁶¹UMLS via Orphanet

⁶²UniProtKB/Swiss-Prot

⁶³Wikipedia

SEGA MCID: SBP001 MIFTS: 51	Subependymal Giant Cell Astrocytoma (SEGA) malady Neuronal diseases, Cancer diseases categories
17 genes, 4 tissues, 185 related diseases, clinical trials.

Subependymal Giant Cell Astrocytoma (SEGA) malady