Subependymal Giant Cell Astrocytoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Subependymal Giant Cell Astrocytoma

MalaCards based summary: Subependymal Giant Cell Astrocytoma, also known as SEGA, is related to tuberous sclerosis complex and giant cell glioblastoma. An important gene associated with Subependymal Giant Cell Astrocytoma is FABP7 (fatty acid binding protein 7, brain), and among its related pathways are FSH signaling pathway and Insulin receptor signalling cascade. The compounds reticulin and eosin have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and thyroid, and related mouse phenotypes are renal/urinary system and no phenotypic analysis.

Aliases & Classifications for Subependymal Giant Cell Astrocytoma

Sources:
⁹Disease Ontology, ⁴²NIH Rare Diseases, ¹¹DISEASES, ⁴⁸Orphanet, ⁶¹UMLS, ⁴⁴Novoseek, ³⁴MeSH, ³⁹NCIt, ⁵⁶SNOMED-CT, ⁶²UMLS via Orphanet
See all sources

Subependymal Giant Cell Astrocytoma, Aliases & Descriptions:

Name: Subependymal Giant Cell Astrocytoma ⁹ ⁴² ¹¹ ⁴⁸ ⁶¹

Sega ⁹ ⁴² ⁴⁸

Astrocytoma Subependymal Giant Cell ⁴⁴

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases

Orphanet: ⁴⁸

Rare neurological diseases

Rare tumors

External Ids:

Disease Ontology⁹ DOID:5077

MeSH³⁴ D001254

SNOMED-CT⁵⁶ 1586004

NCIt³⁹ C3696

UMLS via Orphanet⁶² C0205768

UMLS⁶¹ C0205768

Related Diseases for Subependymal Giant Cell Astrocytoma

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Subependymal Giant Cell Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 151)

id	Related Disease	Score	Top Affiliating Genes
1	tuberous sclerosis complex	32.4	TSC1, TSC2
2	giant cell glioblastoma	31.4	GFAP
3	subependymoma	31.4	TSC2
4	gemistocytic astrocytoma	31.1	GFAP, S100B
5	angiomyolipoma	31.1	MTOR, TSC1, TSC2, VIM
6	neuroblastoma	30.9	TP53, SYP, ENO2
7	astrocytoma	30.7	GFAP, TP53, VIM, NES, TSC2, TSC1
8	central neurocytoma	30.7	GFAP, SYP, MAP2
9	tuberous sclerosis	30.7	GFAP, VIM, NES, TSC2, TSC1, MTOR
10	retinoblastoma	29.8	GFAP, TP53, MTOR, SYP, MAP2, ENO2
11	glioblastoma	29.6	GFAP, TP53, NES, CCK, MTOR, MAP2
12	gliomatosis cerebri	10.6	GFAP
13	dysembryoplastic neuroepithelial tumor	10.6	SYP
14	melanotic neuroectodermal tumor	10.6	SYP
15	mixed glioma	10.6	GFAP
16	perivascular epithelioid cell tumor	10.5	TSC2
17	alexander disease	10.5	GFAP
18	medulloepithelioma	10.5	SYP
19	somatostatinoma	10.5	SST
20	cerebral primitive neuroectodermal tumor	10.5	ENO2
21	epulis	10.5	ENO2
22	lymphangioleiomyomatosis	10.5	TSC2, TSC1
23	intestinal disease	10.4	SST
24	gliosarcoma	10.4	GFAP
25	pineoblastoma	10.4	SYP, GFAP
26	infantile epileptic encephalopathy	10.4	TSC2, TSC1
27	binswanger's disease	10.4	GFAP, SYP
28	cystic kidney	10.4	TSC2, TSC1
29	cowden disease	10.4	TSC2, TSC1
30	syringoma	10.4	GFAP, S100B
31	huntington's disease	10.4	NPY, SST
32	gallbladder disease	10.4	TSC1, CCK
33	myxopapillary ependymoma	10.4	GFAP, S100B
34	lymphedema	10.4
35	thyroiditis	10.4
36	choroid plexus carcinoma	10.4	S100B, GFAP
37	neurilemmoma	10.4	ENO2, GFAP
38	anaplastic ependymoma	10.4	GFAP, S100B
39	pancreatic islet cell tumors	10.4	SST, SYP
40	endocrine gland cancer	10.3	SST, SYP
41	von hippel-lindau disease	10.3	NPY, TSC2
42	kidney angiomyolipoma	10.3	TSC2, TSC1, MTOR
43	hydrocephalus	10.3	TSC1, NES
44	bulimia nervosa	10.3	CCK, NPY
45	peutz-jeghers syndrome	10.3	TSC2, TSC1, MTOR
46	polycystic kidney disease	10.3	TSC2, TSC1, MTOR
47	polycystic kidney disease, autosomal dominant	10.3	TSC2, TSC1, MTOR
48	temporal lobe epilepsy	10.3	GFAP, CALB1, NPY
49	status epilepticus	10.3	ENO2, NPY
50	rhabdoid meningioma	10.3	GFAP, VIM

Graphical network of the top 20 diseases related to Subependymal Giant Cell Astrocytoma:

Symptoms for Subependymal Giant Cell Astrocytoma

Drugs & Therapeutics for Subependymal Giant Cell Astrocytoma

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Subependymal Giant Cell Astrocytoma

Search NIH Clinical Center for Subependymal Giant Cell Astrocytoma

Genetic Tests for Subependymal Giant Cell Astrocytoma

Anatomical Context for Subependymal Giant Cell Astrocytoma

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Subependymal Giant Cell Astrocytoma:

³²

Brain, Spinal cord, Thyroid, Skin, Testes

Animal Models for Subependymal Giant Cell Astrocytoma or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Subependymal Giant Cell Astrocytoma:

³⁶ (show all 11)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	8.7	TP53, TSC2, TSC1, MTOR, NPY
2	no phenotypic analysis	MP:0003012	8.4	TP53, FABP7, SST, CCK, MTOR, SYP
3	embryogenesis phenotype	MP:0005380	8.3	TP53, VIM, NES, TSC2, TSC1, MTOR
4	respiratory system phenotype	MP:0005388	8.3	ENO2, MTOR, TSC1, VIM, TP53
5	cellular phenotype	MP:0005384	7.6	GFAP, TP53, VIM, NES, TSC2, TSC1
6	mortality/aging	MP:0010768	7.3	GFAP, TP53, VIM, NES, TSC2, TSC1
7	homeostasis/metabolism phenotype	MP:0005376	7.2	FABP7, VIM, TP53, GFAP, TSC2, TSC1
8	growth/size/body phenotype	MP:0005378	7.1	GFAP, TP53, VIM, NES, TSC2, TSC1
9	normal phenotype	MP:0002873	7.1	GFAP, TP53, TSC2, SST, MTOR, SYP
10	behavior/neurological phenotype	MP:0005386	5.2	TSC2, FABP7, NES, VIM, TP53, GFAP
11	nervous system phenotype	MP:0003631	4.9	NPY, GFAP, TP53, VIM, NES, FABP7

Publications for Subependymal Giant Cell Astrocytoma

Sources:
⁵¹PubMed
See all sources

Articles related to Subependymal Giant Cell Astrocytoma:

(show top 50) (show all 119)

id	Title	Authors	Year
1	Thyroid transcription factor-1 and epithelial membrane antigen expression in four cases of subependymal giant cell astrocytoma. (25195621)	Chatzopoulos K.... Kostopoulos I.	2014
2	A management strategy for intraventricular subependymal giant cell astrocytomas in tuberous sclerosis complex. (24180681)	Harter D.H.... Weiner H.L.	2014
3	Everolimus Treatment for an Early Infantile Subependymal Giant Cell Astrocytoma With Tuberous Sclerosis Complex. (25143481)	Fukumura S.... Tsutsumi H.	2014
4	Resection of subependymal giant cell astrocytoma guided by intraoperative magnetic resonance imaging and neuronavigation. (23397586)	Ren H.... Xu B.	2013
5	Management of subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex (TSC): Clinical recommendations. (23391693)	JA^A_wiak S.... Curatolo P.	2013
6	Subependymal giant cell astrocytoma associated with tuberous sclerosis presenting with intratumoral bleeding. Case report and review of literature. (23138436)	Sterman H.... Teixeira M.J.	2013
7	Congenital Segmental Lymphedema in Tuberous Sclerosis Complex With Associated Subependymal Giant Cell Astrocytomas Treated with Mammalian Target of Rapamycin Inhibitors. (24056156)	Prato G.... GarrA" M.L.	2013
8	Response of Subependymal Giant Cell Astrocytoma With Spinal Cord Metastasis to Everolimus. (24276039)	Aguilera D.... MacDonald T.J.	2013
9	Everolimus for tumor recurrence after surgical resection for subependymal giant cell astrocytoma associated with tuberous sclerosis complex. (22805244)	Franz D.N.... Krueger D.A.	2013
10	Subependymal giant cell astrocytoma with intratumoral hemorrhage. (23414132)	Ogiwara H.... Morota N.	2013
11	Everolimus in the treatment of subependymal giant cell astrocytomas, angiomyolipomas, and pulmonary and skin lesions associated with tuberous sclerosis complex. (24143074)	Franz D.N.	2013
12	Everolimus long-term safety and efficacy in subependymal giant cell astrocytoma. (23325902)	Krueger D.A.... Franz D.N.	2013
13	Long-term effect of everolimus on epilepsy and growth in children under 3 years of age treated for subependymal giant cell astrocytoma associated with tuberous sclerosis complex. (23567018)	Kotulska K.... JA^A_wiak S.	2013
14	Outcomes of resecting subependymal giant cell astrocytoma (SEGA) among patients with SEGA-related tuberous sclerosis complex: a national claims database analysis. (22375958)	Sun P.... Krueger D.	2012
15	Subependymal giant cell astrocytoma: Cytological findings. (23326038)	Azarpira N.... Rakei M.	2012
16	Squash cytology of subependymal giant cell astrocytoma: report of four cases with brief review of literature. (22431322)	Jaiswal S.... Behari S.	2012
17	Mitotic activity in subependymal giant cell astrocytoma. (23239637)	JimAcnez-Heffernan J.A.... Salas C.	2012
18	Everolimus tablets for patients with subependymal giant cell astrocytoma. (21806479)	Turner S.G.... Reardon D.A.	2011
19	Potential of mTOR inhibitors for the treatment of subependymal giant cell astrocytomas in tuberous sclerosis complex. (21415462)	Major P.	2011
20	Bulky subependymal giant cell astrocytoma with profuse blood supply without tuberous sclerosis. (20956931)	Li W.Q.... Yu H.Y.	2010
21	Rapamycin as an alternative to surgical treatment of subependymal giant cell astrocytomas in a patient with tuberous sclerosis complex. (20887114)	Birca A.... Major P.	2010
22	Neonatal subependymal giant cell astrocytoma: new case and review of literature. (17275668)	Raju G.P.... Sahin M.	2007
23	Upregulation of the WNT pathway in tuberous sclerosis-associated subependymal giant cell astrocytomas. (17071037)	Jozwiak J.... Wlodarski P.	2007
24	Cytologic characteristics of subependymal giant cell astrocytoma in squash smears: morphometric comparisons with gemistocytic astrocytoma and giant cell glioblastoma. (17536538)	Kim S.H.... Kim T.S.	2007
25	Developmental origin of subependymal giant cell astrocytoma in tuberous sclerosis complex. (15851742)	Ess K.C.... Gutmann D.H.	2005
26	Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation. (15624760)	Chan J.A.... Kwiatkowski D.J.	2004
27	Subependymal giant cell astrocytoma with positive tuberin expression--case report. (14723270)	Tabuchi S.... Watanabe T.	2003
28	Rapid regrowth of solitary subependymal giant cell astrocytoma--case report. (12064158)	Yamamoto K.... Ushio Y.	2002
29	Secondary parathyroid hyperplasia in tuberous sclerosis: report of a case with large eosinophilic ganglion-like cells similar to those of subependymal giant cell astrocytoma, tubers, and atypical angiomyolipoma. (11812950)	Martin H.L.... Albores-Saavedra J.	2002
30	Subependymal giant cell astrocytoma: clinical and neuroimaging features of four cases. (11322123)	Nishio S.... Fukui M.	2001
31	Subependymal giant cell astrocytoma associated with tuberous sclerosis exhibiting rapid regrowth after 17 years: a case report]. (10396738)	Kawasaki S.... Ohtsuki Y.	1999
32	Image interpretation session: 1998. Tuberous sclerosis with multiple bilateral renal cysts and a subependymal giant cell astrocytoma. (10722364)		1999
33	Early diagnosis of subependymal giant cell astrocytoma in patients with tuberous sclerosis. (9568761)	Torres O.A.... Bruce D.	1998
34	Subependymal giant-cell astrocytoma associated with tuberous sclerosis: case report. (9795959)	ErgA1n R.... TaA9kin Y.	1998
35	Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors. (9403714)	Henske E.P.... Yeung R.S.	1997
36	Immunohistochemical characterization of subependymal giant cell astrocytomas. (8928613)	Lopes M.B.... VandenBerg S.R.	1996
37	Hemorrhagic subependymal giant cell astrocytoma. (7761172)	Kalina P.... Hyman R.A.	1995
38	Immunohistochemical and electron microscopic study of subependymal giant cell astrocytoma. (8867692)	Huang M.C.... Takakura K.	1995
39	A neonatal huge subependymal giant cell astrocytoma: case report. (7808622)	Oikawa S.... Kobayashi N.	1994
40	Cytomorphology of subependymal giant cell astrocytoma. A case report. (8465641)	Ahluwalia C.K.... Chandrasoma P.T.	1993
41	The cystic growth of a subependymal giant-cell astrocytoma with tuberous sclerosis. (1405432)	Sugita Y.... Morimatsu M.	1992
42	Tuberous sclerosis complex: oligosymptomatic variant associated with subependymal giant-cell astrocytoma. (1749677)	Rieger E.... Urban C.	1991
43	Clinical and immunohistochemical studies of subependymal giant cell astrocytomas associated with tuberous sclerosis. (1705105)	Iwasaki Y.... Aoki N.	1990
44	Rare subependymal giant-cell astrocytoma in a neonate with tuberous sclerosis. (2124070)	Tien R.D.... Duberg A.	1990
45	Subependymal giant-cell astrocytoma associated with tuberous sclerosis. Do subependymal nodules grow? (2702677)	Fujiwara S.... Nishio S.	1989
46	Subependymal giant-cell astrocytoma in children. An unusual discrepancy between histological and clinical features. (3286833)	Chow C.W.... Lewis E.A.	1988
47	Subependymal giant-cell astrocytoma. A case report. (3218563)	Gangemi M.... Insabato L.	1988
48	Paratesticular neuroblastoma associated with subependymal giant cell astrocytoma. (7452809)	Krieger J.N.... Keuhnelian J.G.	1980
49	Subependymal giant-cell astrocytoma. Case report with ultrastructural study. (430139)	Sima A.A.... Robertson D.M.	1979
50	Recurrent subependymal giant-cell astrocytoma in the absence of tuberous sclerosis. Case report. (758371)	Halmagyi G.M.... Allsop J.L.	1979

Genes related to Subependymal Giant Cell Astrocytoma

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Subependymal Giant Cell Astrocytoma:

(show all 16)

- Elite gene

id	Symbol	Description	Score	Implication
1	FABP7	fatty acid binding protein 7, brain	20.67	GeneCards inferred via : Publications (show sections)
2	TSC1	tuberous sclerosis 1	19.42	GeneCards inferred via : Publications, Disorders (show sections)
3	NES	nestin	18.17	GeneCards inferred via : Publications (show sections)
4	GFAP	glial fibrillary acidic protein	16.92	GeneCards inferred via : Publications, Disorders (show sections)
5	TSC2	tuberous sclerosis 2	15.67	GeneCards inferred via : Publications, Disorders (show sections)
6	NPY	neuropeptide Y	14.42	GeneCards inferred via : Publications (show sections)
7	SYP	synaptophysin	13.17	GeneCards inferred via : Publications, Disorders (show sections)
8	MTOR	mechanistic target of rapamycin (serine/threonine kinase)	11.92	GeneCards inferred via : Publications, Disorders (show sections)
9	SST	somatostatin	10.67	GeneCards inferred via : Publications (show sections)
10	CCK	cholecystokinin	9.42	GeneCards inferred via : Publications (show sections)
11	S100B	S100 calcium binding protein B	8.17	GeneCards inferred via : Publications (show sections)
12	VIM	vimentin	6.92	GeneCards inferred via : Publications (show sections)
13	MAP2	microtubule-associated protein 2	5.67	GeneCards inferred via : Publications (show sections)
14	TP53	tumor protein p53	4.42	GeneCards inferred via : Publications (show sections)
15	CALB1	calbindin 1, 28kDa	3.17	GeneCards inferred via : Publications (show sections)
16	ENO2	enolase 2 (gamma, neuronal)	1.92	GeneCards inferred via : Disorders (show sections)

Products for genes related to Subependymal Giant Cell Astrocytoma disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	16	-	16	16
2	Novus Biologicals	15	14	16	-

Variations for Subependymal Giant Cell Astrocytoma

Expression for genes affiliated with Subependymal Giant Cell Astrocytoma

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Subependymal Giant Cell Astrocytoma

Search GEO for disease gene expression data for Subependymal Giant Cell Astrocytoma.

Pathways for genes affiliated with Subependymal Giant Cell Astrocytoma

Sources:
⁴⁹PathCards, ³⁷NCBI BioSystems Database, ⁵⁴Reactome, ³⁰KEGG, ⁵Cell Signaling Technology, ⁵²QIAGEN, ⁵⁹Thomson Reuters, ⁵³R&D Systems, ¹³EMD Millipore
See all sources

Pathways related to Subependymal Giant Cell Astrocytoma according to GeneCards/GeneDecks:

(show all 23)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	FSH signaling pathway³⁷	9.9	MTOR, TSC2
2	Insulin receptor signalling cascade⁵⁴ Show member pathways mTORC1-mediated signalling⁵⁴ PKB-mediated events⁵⁴ IRS-related events⁵⁴ Inhibition of TSC complex formation by PKB⁵⁴ IRS-mediated signalling⁵⁴ IRS-related events triggered by IGF1R⁵⁴ PDE3B signalling⁵⁴ SHC-mediated signalling⁵⁴ IRS activation⁵⁴ Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)⁵⁴ Energy dependent regulation of mTOR by LKB1-AMPK⁵⁴ S6K1-mediated signalling⁵⁴ Release of eIF4E⁵⁴ IGF1R signaling cascade⁵⁴ Regulation of Rheb GTPase activity by AMPK⁵⁴ Signaling by Insulin receptor⁵⁴ SHC-related events⁵⁴ SOS-mediated signalling⁵⁴ S6K1 signalling⁵⁴ TOR signaling³⁷ PI3K Cascade⁵⁴ Regulation of AMPK activity via LKB1⁵⁴ mTOR signalling⁵⁴ SHC activation⁵⁴ SHC-related events triggered by IGF1R⁵⁴ Signal attenuation⁵⁴	9.7	TSC2, TSC1, MTOR
3	mTOR signaling pathway³⁰ Show member pathways mTOR signaling pathway³⁷	9.7	MTOR, TSC1, TSC2
4	Translational Control⁵	9.7	MTOR, TSC1, TSC2
5	Insulin Signaling³⁷	9.7	TSC2, TSC1, MTOR
6	Glioblastoma Multiforme⁵²	9.4	TP53, TSC2, TSC1
7	Endometrial cancer³⁰ Show member pathways Colorectal cancer³⁰ Signal transduction PTEN pathway⁵⁹ Acute myeloid leukemia³⁰	9.3	MTOR, TSC2, TP53
8	Thyroid hormone signaling pathway³⁰	9.3	TP53, TSC2, MTOR
9	PI-3K cascade⁵⁴ Show member pathways Downregulation of ERBB4 signaling⁵⁴ AKT phosphorylates targets in the nucleus⁵⁴ Signaling by SCF-KIT⁵⁴ PI3K events in ERBB2 signaling⁵⁴ Fc epsilon receptor (FCERI) signaling⁵⁴ PI3K events in ERBB4 signaling⁵⁴ Signaling by ERBB4⁵⁴ GAB1 signalosome⁵⁴ Negative regulation of the PI3K/AKT network⁵⁴ Role of LAT2/NTAL/LAB on calcium mobilization⁵⁴ PIP3 activates AKT signaling⁵⁴ Regulation of KIT signaling⁵⁴ AKT phosphorylates targets in the cytosol⁵⁴ AKT-mediated inactivation of FOXO1A⁵⁴ PI3K/AKT Signaling in Cancer⁵⁴ Constitutive PI3K/AKT Signaling in Cancer⁵⁴ PI3K/AKT activation⁵⁴	9.2	GFAP, TSC2, MTOR, S100B
10	Spinal Cord Injury³⁷	9.1	VIM, TP53, GFAP
11	Integrated Breast Cancer Pathway³⁷	9.0	TP53, TSC2, TSC1, MTOR
12	Akt Signaling Pathway⁵³	9.0	MTOR, TSC1, TSC2, TP53
13	AMPK signaling³⁷	9.0	TP53, TSC2, TSC1, MTOR
14	Glioma³⁰ Show member pathways Melanoma³⁰ Non-small cell lung cancer³⁰ Bladder cancer³⁰ Prostate cancer³⁰ Signaling Pathways in Glioblastoma³⁷	9.0	TP53, TSC2, TSC1, MTOR
15	Prostate cancer³⁰ Show member pathways Prostate Cancer³⁷ Integrated Cancer pathway³⁷ Steroid Biosynthesis³⁷	9.0	TP53, TSC2, TSC1, MTOR
16	PI3K-Akt signaling pathway³⁰	9.0	TP53, TSC2, TSC1, MTOR
17	Development IGF 1 receptor signaling⁵⁹ Show member pathways Development IGF RI signaling¹³ Immune response IL 4 signaling pathway⁵⁹ Signal transduction AKT signaling⁵⁹	9.0	TP53, TSC2, TSC1, MTOR
18	G protein signaling Ras family GTPases in kinase cascades scheme ⁵⁹ Show member pathways MAPK Cascade³⁷ Immune response Oncostatin M signaling via MAPK in human cells⁵⁹ Oncostatin M Signaling Pathway³⁷ Activation of the AP-1 family of transcription factors⁵⁴	9.0	MAP2, MTOR, TP53
19	Cytoplasmic microtubules¹³ Show member pathways Cytoskeleton remodeling Neurofilaments⁵⁹	9.0	GFAP, VIM, NES, MAP2
20	ERK Signaling⁵² Show member pathways ILK Signaling⁵² Molecular Mechanisms of Cancer⁵² Rho Family GTPases⁵² MAPK Signaling⁵²	8.6	TSC1, TSC2, VIM, TP53, GFAP
21	LKB1 signaling events³⁷	8.5	TP53, TSC2, TSC1, MTOR, MAP2
22	Signaling by GPCR⁵⁴ Show member pathways GPCR downstream signaling⁵⁴ Signal Transduction⁵⁴	7.4	GFAP, TP53, TSC2, TSC1, SST, CCK
23	Neuroscience⁵	7.1	NPY, GFAP, FABP7, SYP, MAP2, CALB1

Compounds for genes affiliated with Subependymal Giant Cell Astrocytoma

Sources:
⁴⁴Novoseek, ⁵⁰PharmGKB, ¹²DrugBank, ⁶⁰Tocris Bioscience, ²⁹IUPHAR, ²⁵HMDB
See all sources

Compounds related to Subependymal Giant Cell Astrocytoma according to GeneCards/GeneDecks:

(show top 50) (show all 159)

id	Compound	Score	Top Affiliating Genes
1	reticulin⁴⁴	9.4	GFAP, VIM, SYP, S100B
2	eosin⁴⁴	9.4	S100B, GFAP, VIM
3	spec-t⁴⁴	9.3	ENO2, SST, TSC1, GFAP
4	n-acetylaspartate⁴⁴	9.2	GFAP, SYP, CALB1
5	streptozotocin⁴⁴	9.0	SYP, NES, VIM, GFAP, SST, NPY
6	s 100⁴⁴	8.9	GFAP, VIM, SYP, S100B, ENO2
7	catecholamine⁴⁴	8.7	VIM, SYP, ENO2, NPY, S100B
8	ganglioside⁴⁴	8.6	SYP, ENO2, GFAP, VIM, NES, MAP2
9	vinblastine⁴⁴ ⁵⁰ ¹²	10.5	MAP2, SST, VIM, TP53, NPY
10	tetrodotoxin⁴⁴ ⁶⁰ ²⁹	10.5	CALB1, GFAP, CCK, ENO2, NPY
11	cocaine⁴⁴ ¹²	9.5	VIM, CCK, MAP2, NPY, S100B, GFAP
12	methamphetamine⁴⁴ ⁵⁰ ¹²	10.5	CALB1, GFAP, MAP2, NPY
13	kainate⁴⁴ ²⁹	9.4	NPY, GFAP, NES, SYP, MAP2, CALB1
14	hematoxylin⁴⁴	8.4	S100B, MAP2, SYP, VIM, GFAP, ENO2
15	dbc-amp⁴⁴	8.4	ENO2, S100B, MAP2, SYP, VIM, GFAP
16	acth⁴⁴	8.4	S100B, GFAP, CCK, SYP, ENO2, NPY
17	silver⁴⁴	8.3	SYP, ENO2, GFAP, CALB1, MAP2
18	l-amino acid⁴⁴	8.3	SYP, S100B, ENO2, MAP2, CALB1
19	leucine⁴⁴	8.2	SYP, ENO2, S100B, MTOR, TSC2, VIM
20	glutamine⁴⁴	8.2	S100B, GFAP, VIM, CCK, SYP, ENO2
21	dmso⁴⁴	8.2	NES, NPY, ENO2, VIM, MAP2
22	lactate⁴⁴	8.0	ENO2, NPY, SST, S100B, GFAP, VIM
23	formaldehyde⁴⁴ ²⁵	8.8	NPY, CALB1, SYP, GFAP, VIM, ENO2
24	potassium⁴⁴ ²⁵ ¹²	9.8	ENO2, CALB1, MAP2, GFAP, SYP, S100B
25	lipid⁴⁴	7.7	MTOR, NES, ENO2, GFAP, TSC2, SYP
26	nmda⁴⁴ ²⁹	8.7	SYP, ENO2, NPY, CALB1, MAP2, VIM
27	bromodeoxyuridine⁴⁴	7.7	S100B, ENO2, CALB1, NES, VIM, GFAP
28	glycogen⁴⁴ ²⁵	8.6	SYP, MTOR, TSC1, TSC2, VIM, GFAP
29	5-hydroxytryptamine⁴⁴	7.5	SST, CCK, GFAP, NPY, ENO2, CALB1
30	arginine⁴⁴	7.5	MTOR, CCK, S100B, TP53, GFAP, VIM
31	progesterone⁴⁴ ²⁹ ⁶⁰ ²⁵ ¹²	11.5	VIM, GFAP, ENO2, S100B, MAP2, SYP
32	adenylate⁴⁴	7.4	SST, NPY, S100B, GFAP, VIM, MAP2
33	forskolin⁴⁴ ⁵⁰ ¹²	9.4	GFAP, VIM, NPY, ENO2, S100B, CALB1
34	nitric oxide⁴⁴ ²⁵ ¹²	9.4	NES, NPY, MAP2, CALB1, S100B, SYP
35	norepinephrine⁴⁴ ²⁵ ¹²	9.3	ENO2, MAP2, SYP, CCK, NPY, CALB1
36	serine⁴⁴	7.2	VIM, TSC2, S100B, TP53, GFAP, MAP2
37	dexamethasone⁴⁴ ⁵⁰ ²⁹ ¹²	10.0	MTOR, SYP, VIM, CALB1, S100B, ENO2
38	atp⁴⁴ ²⁹	7.9	NPY, ENO2, CALB1, MTOR, VIM, GFAP
39	acetylcholine⁴⁴ ⁵⁰ ²⁹ ²⁵ ¹²	10.9	SST, CCK, NES, VIM, GFAP, NPY
40	dopamine⁴⁴ ²⁹ ²⁵ ¹²	9.8	S100B, CCK, NPY, GFAP, NES, SST
41	paraffin⁴⁴	6.8	NPY, ENO2, S100B, MAP2, SYP, TSC1
42	choline⁴⁴ ²⁵ ¹²	8.8	S100B, ENO2, NPY, CALB1, MAP2, SYP
43	vegf⁴⁴	6.4	ENO2, S100B, MAP2, SYP, MTOR, SST
44	tyrosine⁴⁴	6.3	ENO2, TSC1, NPY, S100B, CALB1, CCK
45	glucose⁴⁴	6.3	GFAP, NES, TSC2, TSC1, SST, CCK
46	glutamate⁴⁴	6.2	NPY, ENO2, S100B, CALB1, MAP2, SYP
47	gaba⁴⁴	6.2	SYP, MAP2, CALB1, S100B, ENO2, NPY
48	testosterone⁴⁴ ⁶⁰ ²⁵ ¹²	9.0	S100B, CALB1, MAP2, SYP, MTOR, CCK
49	estrogen⁴⁴	5.9	NPY, ENO2, S100B, CALB1, MAP2, SYP
50	retinoic acid⁴⁴ ²⁵	6.2	S100B, CALB1, MAP2, SYP, MTOR, CCK

GO Terms for genes affiliated with Subependymal Giant Cell Astrocytoma

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Subependymal Giant Cell Astrocytoma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	TSC1-TSC2 complex	GO:033596	10.0	TSC2, TSC1
2	intermediate filament	GO:005882	9.2	GFAP, VIM, NES
3	extracellular space	GO:005615	8.5	NPY, ENO2, S100B, CCK, SST
4	neuronal cell body	GO:043025	8.0	S100B, FABP7, TSC2, SST, MAP2, CALB1
5	cytoplasm	GO:005737	7.0	GFAP, TP53, VIM, NES, FABP7, TSC2
6	cytosol	GO:005829	6.9	GFAP, TP53, VIM, TSC2, TSC1, MTOR

Biological processes related to Subependymal Giant Cell Astrocytoma according to GeneCards/GeneDecks:

(show all 21)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of TOR signaling	GO:032007	10.1	TSC1, TSC2
2	Bergmann glial cell differentiation	GO:060020	10.1	VIM, GFAP
3	astrocyte development	GO:014002	10.0	VIM, GFAP
4	intermediate filament organization	GO:045109	10.0	GFAP, VIM
5	negative regulation of cell size	GO:045792	10.0	MTOR, TSC1, TSC2
6	regulation of protein kinase activity	GO:045859	10.0	MTOR, TSC1
7	regulation of neuronal synaptic plasticity	GO:048168	10.0	S100B, SYP
8	central nervous system neuron development	GO:021954	9.9	MAP2, NPY
9	long-term synaptic potentiation	GO:060291	9.8	GFAP, S100B
10	insulin receptor signaling pathway	GO:008286	9.8	TSC2, TSC1, MTOR
11	negative regulation of neuron projection development	GO:010977	9.8	VIM, GFAP
12	positive regulation of protein oligomerization	GO:032461	9.7	CCK, TP53
13	cell cycle arrest	GO:007050	9.5	TSC1, TSC2, TP53
14	response to amino acid	GO:043200	9.5	MTOR, SST
15	axonogenesis	GO:007409	9.5	S100B, MAP2, CCK
16	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.5	TP53, CCK, MTOR
17	central nervous system development	GO:007417	9.4	S100B, NES, TP53
18	cellular response to hypoxia	GO:071456	9.4	TP53, MTOR, S100B
19	release of cytochrome c from mitochondria	GO:001836	9.4	CCK, TP53
20	cellular response to organic substance	GO:071310	9.2	CALB1, MAP2, SYP
21	negative regulation of cell proliferation	GO:008285	9.1	TP53, FABP7, TSC2, TSC1, SST