MCID: SBS003
MIFTS: 50

Substance Abuse malady

Mental diseases category
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Summaries for Substance Abuse

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Disease Ontology:8 A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning.

MalaCards based summary: Substance Abuse, also known as substance abuse problem, is related to anxiety disorder and antisocial personality disorder. An important gene associated with Substance Abuse is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are Histidine metabolism and Tyrosine metabolism p.1 dopamine . The compounds (r)-(-)-deprenyl hydrochloride and phenethylamine, have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and liver, and related mouse phenotypes are nervous system and behavior/neurological.

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Wikipedia:65 Substance abuse, also known as drug abuse, is a patterned use of a substance (drug) in which the user... more...

Aliases & Classifications for Substance Abuse

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Substance Abuse, Aliases & Descriptions:

Name: Substance Abuse 8 10
 
Substance Abuse Problem 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:302
NCIt39 C16522
SNOMED-CT57 66214007, 26416006
ICD9CM27 305
MeSH34 D019966

Related Diseases for Substance Abuse

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Diseases related to Substance Abuse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1anxiety disorder31.2MAOA
2antisocial personality disorder31.2MAOA, HTR1B
3conduct disorder31.1MAOA, DRD5
4personality disorder30.9HTR1B, MAOA, MAOB
5generalized anxiety disorder30.7MAOA, SLC6A2
6bipolar disorder30.5MAOA, MAOB, DRD5, SLC6A2
7borderline personality disorder30.4MAOA, HTR1B
8panic disorder30.4SLC6A2, MAOA
9anorexia nervosa30.3SLC6A2, MAOA
10obesity30.1SLC6A2, MAOB, MAOA
11mood disorder30.1HTR1B, MAOA, MAOB, SLC6A2
12alcohol dependence29.9MAOA, HTR1B, ADH4
13schizophrenia29.9HTR1B, MAOA, MAOB, DRD5, TDO2, SLC6A2
14parkinson's disease29.7SLC6A2, MAOB, MAOA, HTR1B
15attention deficit hyperactivity disorder29.7HTR1B, MAOA, DRD5, SLC6A2
16cannabis abuse10.5
17hepatitis10.5
18hiv/aids10.5
19alcohol abuse10.5
20oppositional defiant disorder10.4SLC6A2
21hepatitis c10.4
22drug addiction10.4
23nicotine addiction10.4
24cocaine abuse10.3
25pathological gambling10.3
26dementia10.3
27agoraphobia10.3SLC6A2, MAOA
28fetal alcohol syndrome10.2
29opioid abuse10.2
30eating disorder10.2
31substance dependence10.2
32developmental disabilities10.2
33pure autonomic failure10.2MAOB, MAOA
34hepatic encephalopathy10.2MAOB, MAOA
35psychotic disorder10.1MAOA, MAOB
36asthma10.1
37brain injury10.1
38hepatitis b10.1
39hiv-110.1
40liver disease10.1
41traumatic brain injury10.1
42post-traumatic stress disorder10.1
43hepatitis d10.1
44bipolar i disorder10.1
45amphetamine abuse10.1
46somatization disorder10.1
47phencyclidine abuse10.1
48frontotemporal dementia10.1
49antidepressant type abuse10.1
50schizoaffective disorder10.1

Graphical network of the top 20 diseases related to Substance Abuse:



Diseases related to substance abuse

Symptoms for Substance Abuse

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Drugs & Therapeutics for Substance Abuse

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Drug clinical trials:

Search ClinicalTrials for Substance Abuse

Search NIH Clinical Center for Substance Abuse

Genetic Tests for Substance Abuse

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Anatomical Context for Substance Abuse

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MalaCards organs/tissues related to Substance Abuse:

32
Testes, Brain, Liver, Heart, Kidney, Hypothalamus, Pituitary, Subthalamic nucleus

Animal Models for Substance Abuse or affiliated genes

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MGI Mouse Phenotypes related to Substance Abuse:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.1MAOB, DRD5, TDO2, SLC6A2, MAOA
2MP:00053867.5SLC6A2, TDO2, MAOB, MAOA, HTR1B

Publications for Substance Abuse

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Articles related to Substance Abuse:

(show top 50)    (show all 578)
idTitleAuthorsYear
1
Service utilization of asians and other racial-ethnic groups: comparisons in a state substance abuse treatment system. (24093520)
2014
2
Substance Abuse, Violence, and HIV/AIDS (SAVA) Syndemic Effects on Viral Suppression Among HIV Positive Women of Color. (25397666)
2014
3
Criminal justice outcomes after engagement in outpatient substance abuse treatment. (24238717)
2014
4
The tangled branches (las ramas enredadas): sexual risk, substance abuse, and intimate partner violence among Hispanic men who have sex with men. (24084703)
2014
5
The Relationship of State Medicaid Coverage to Medicaid Acceptance Among Substance Abuse Providers in the United States. (24407938)
2014
6
Cost-effectiveness of rapid HCV testing and simultaneous rapid HCV and HIV testing in substance abuse treatment programs. (25291977)
2014
7
A review of existing treatments for substance abuse among the elderly and recommendations for future directions. (23471422)
2013
8
How the states stack up: disparities in substance abuse outpatient treatment completion rates for minorities. (23664124)
2013
9
Approaches to substance abuse in Cuba: Ricardo A. GonzA!lez MD PhD DrSc. Psychiatrist and consulting professor, Eduardo B. Ordaz. Psychiatric Hospital, Havana. Interviewed by Christina Mills. (24253343)
2013
10
Utilization of communication technology by patients enrolled in substance abuse treatment. (23107600)
2013
11
Substance abuse journal: new beginnings. (24159902)
2013
12
Future research needs for evaluating the integration of mental health and substance abuse treatment with primary care. (24042241)
2013
13
Substance use among women receiving post-rape medical care, associated post-assault concerns and current substance abuse: results from a national telephone household probability sample. (23380490)
2013
14
Work needed to close gaps in coverage for mental health, substance abuse treatment. (24386795)
2013
15
Does Substance Abuse Fall Exclusively Along the Externalizing Spectrum? (24328838)
2013
16
The provider perception inventory: psychometrics of a scale designed to measure provider stigma about HIV, substance abuse, and MSM behavior. (23082899)
2013
17
Gene-environment correlation in the development of adolescent substance abuse: selection effects of child personality and mediation via contextual risk factors. (23398757)
2013
18
Employment status of veterans receiving substance abuse treatment from the U.S. Department of Veterans Affairs. (23370624)
2013
19
Predictors of retention in a drug-free unit/substance abuse treatment in prison. (23706657)
2013
20
Substance screening and referral for substance abuse treatment in an integrated mental health care program. (23280462)
2013
21
Comment on: pilot evaluation of a substance abuse prevention group intervention for at-risk bariatric surgery candidates. (23477955)
2013
22
Substance abuse as a risk factor for violence in mental illness: some implications for forensic psychiatric practice and clinical ethics. (23722099)
2013
23
Pilot evaluation of a substance abuse prevention group intervention for at-risk bariatric surgery candidates. (23473996)
2013
24
Substance Abuse Treatment, HIV/AIDS, and the Continuum of Response for People Who Inject Drugs. (23243517)
2012
25
Depression as a mediator of the association between substance abuse and negative parenting of fathers. (22243417)
2012
26
Affective Awareness in Parenting of Fathers with Co-Occurring Substance Abuse and Intimate Partner Violence. (23710257)
2012
27
Organizational consequences of staff turnover in outpatient substance abuse treatment programs. (22154028)
2012
28
Changing pattern of substance abuse in patients attending a de-addiction centre in north India (1978-2008). (22825602)
2012
29
Substance abuse among migrant workers of Thai-Laos border, Thailand. (23140041)
2012
30
Community capacity assessment in preventing substance abuse: a participatory approach. (23193506)
2012
31
How to measure outcome in clinical trials of substance abuse treatment. (22372699)
2012
32
Culturally competent substance abuse treatment with transgender persons. (22873185)
2012
33
Substance abuse and movement disorders: complex interactions and comorbidities. (23030352)
2012
34
The dangers of substance abuse in adolescents with chronic kidney disease: a review of the literature. (22558679)
2012
35
A snapshot of North Carolina's public mental health, developmental disabilities, and substance abuse service system. (22779165)
2012
36
Disparities in completion of substance abuse treatment among Latino subgroups in Los Angeles County, CA. (22658303)
2012
37
Chronic illness histories of adults entering treatment for co-occurring substance abuse and other mental health disorders. (22211340)
2012
38
Resources and training in outpatient substance abuse treatment facilities. (22154031)
2012
39
Relationship of substance abuse to dependence in the U.S. general population. (22456242)
2012
40
Using the theory of planned behavior to examine residential substance abuse workers intention to use evidence-based practices. (22686963)
2012
41
Low and moderate alcohol consumption during pregnancy: effects on social behaviour and propensity to develop substance abuse in later life. (23164117)
2012
42
Substance abuse prevalence and its relation to scholastic achievement and sport factors: an analysis among adolescents of the Herzegovina-Neretva Canton in Bosnia and Herzegovina. (22480230)
2012
43
Models of neurological disease (substance abuse): self-administration in monkeys. (22382996)
2011
44
Increasing ethnic minority participation in substance abuse clinical trials: lessons learned in the National Institute on Drug Abuse's Clinical Trials Network. (21988575)
2011
45
Editors' introduction: Identifying and assessing promising practices for criminal justice clients--California Substance Abuse Research Consortium (SARC) meetings, 2010. (22185034)
2011
46
Gender differences and conduct disorder among American Indian adolescents in substance abuse treatment. (12733762)
2003
47
Diagnosing antisocial personality disorder among substance abusers: the scid versus the MCMI-II. (11727884)
2001
48
A functionally deficient DRD2 variant [Ser311Cys] is not linked to alcoholism and substance abuse. (9650635)
1998
49
Substance abuse vulnerability and D2 receptor genes. (7681236)
1993
50
The antecedents of women's crack cocaine abuse: family substance abuse, sexual abuse, depression and illicit drug use. (8246316)
1993

Variations for Substance Abuse

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Expression for genes affiliated with Substance Abuse

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Expression patterns in normal tissues for genes affiliated with Substance Abuse

Search GEO for disease gene expression data for Substance Abuse.

Pathways for genes affiliated with Substance Abuse

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Pathways related to Substance Abuse according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
histamine biosynthesis37
9.6MAOB, MAOA
29.6MAOB, MAOA
3
Show member pathways
choline degradation I37
glycine biosynthesis III37
serine and glycine biosynthesis37
glycine betaine degradation37
glycine biosynthesis37
9.6MAOA, MAOB
4
Show member pathways
citrulline-nitric oxide cycle37
arginine degradation I (arginase pathway)37
proline degradation37
glutamine degradation I37
proline biosynthesis I37
superpathway of citrulline metabolism37
proline biosynthesis II (from arginine)37
citrulline biosynthesis37
arginine degradation VI (arginase 2 pathway)37
Urea cycle and metabolism of amino groups37
asparagine biosynthesis I37
4-hydroxyproline degradation I37
citrulline degradation37
9.6MAOB, MAOA
5
Show member pathways
9.6MAOA, MAOB
69.6MAOA, MAOB
79.6MAOB, MAOA
89.6MAOA, MAOB
99.2MAOA, HTR1B
10
Show member pathways
9.1DRD5, HTR1B
11
Show member pathways
phenylalanine utilization37
noradrenaline and adrenaline degradation37
phenylalanine degradation IV37
9.1ADH4, MAOA, MAOB
12
Show member pathways
9.1MAOB, MAOA, ADH4
13
Show member pathways
9.1MAOB, MAOA, ADH4
14
Show member pathways
9.1ADH4, MAOA, MAOB
15
Show member pathways
Serotonin Transporter Activity37
9.1SLC6A2, TDO2, MAOA
16
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)37
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA37
tryptophan degradation37
glutaryl-CoA degradation37
serotonin degradation37
NAD de novo biosynthesis37
superpathway of melatonin degradation37
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde37
tryptophan utilization I37
melatonin degradation I37
9.0TDO2, MAOB, MAOA
17
Show member pathways
9.0TDO2, MAOB, MAOA
18
Show member pathways
8.5TDO2, MAOB, MAOA, ADH4
19
Show member pathways
8.3HTR1B, MAOA, MAOB, DRD5

Compounds for genes affiliated with Substance Abuse

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Compounds related to Substance Abuse according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1(r)-(-)-deprenyl hydrochloride6110.0MAOA, MAOB
2phenethylamine,4410.0MAOA, MAOB
3brofaromine4410.0MAOA, MAOB
4pirlindole449.9MAOA, MAOB
51-methyl-4-phenyl-2,3-dihydropyridinium449.9MAOA, MAOB
6toloxatone449.9MAOA, MAOB
7pyrazoline449.9MAOA, MAOB
8bifemelane hydrochloride619.9MAOB, MAOA
94,6-Dihydroxyquinoline249.9MAOA, MAOB
10isocarboxazid44 1110.9MAOA, MAOB
11iproniazid44 1110.9MAOB, MAOA
12rasagiline mesylate619.9MAOA, MAOB
13lazabemide hydrochloride619.9MAOA, MAOB
141,4-diphenyl-2-butene449.8MAOA, MAOB
15lazabemide449.8MAOB, MAOA
16m-tyramine449.7MAOA, MAOB, SLC6A2
17p-chloroamphetamine449.7MAOA, SLC6A2, MAOB
18nomifensine44 28 1111.7MAOA, SLC6A2, MAOB
19phentermine44 1110.7MAOA, SLC6A2, MAOB
20d amphetamine449.7MAOB, MAOA, SLC6A2
21mdma449.7MAOA, MAOB, SLC6A2
22mhpg449.7MAOA, SLC6A2, MAOB
23homovanillic acid44 2410.6MAOB, MAOA, SLC6A2
241 methyl 4 phenylpyridinium449.6SLC6A2, MAOA, MAOB
25sertraline44 28 50 24 1113.6SLC6A2, MAOA, MAOB
265-hydroxyindoleacetic acid44 2410.6SLC6A2, MAOB, MAOA
27tyramine44 28 2411.6SLC6A2, MAOB, MAOA
28harman449.6MAOB, MAOA
29amitriptyline44 28 50 1112.6MAOA, SLC6A2, MAOB
30methamphetamine44 50 1111.4MAOA, MAOB, SLC6A2
316-hydroxydopamine449.4MAOA, SLC6A2, MAOB
32amphetamine44 50 1111.3SLC6A2, MAOB, MAOA
33milacemide449.3MAOB, MAOA
34citalopram44 50 24 1112.3MAOB, SLC6A2, MAOA
35clomipramine44 50 1111.2HTR1B, SLC6A2, MAOA
36paroxetine44 50 28 1112.2SLC6A2, HTR1B, MAOA
37mptp449.2MAOA, MAOB, SLC6A2
38tryptamine44 28 2411.2MAOB, HTR1B, MAOA
39Serotonin249.2MAOA, MAOB, HTR1B
40methylphenidate44 50 1111.2MAOB, SLC6A2, DRD5, MAOA
41catecholamine449.1MAOB, DRD5, SLC6A2, MAOA
42ropinirole44 1110.1DRD5, HTR1B, MAOB
43apomorphine28 44 1111.0MAOB, HTR1B, DRD5
44maoa448.9MAOB, MAOA, HTR1B, SLC6A2
45fluoxetine44 50 28 1111.9SLC6A2, MAOB, HTR1B, MAOA
46amine448.8MAOA, SLC6A2, MAOB, HTR1B
47levodopa44 119.7MAOA, HTR1B, MAOB, DRD5
48norepinephrine44 24 1110.6DRD5, SLC6A2, MAOB, MAOA
49dopamine44 28 24 1111.3HTR1B, MAOA, SLC6A2, DRD5, MAOB
505-hydroxytryptamine448.2HTR1B, MAOB, TDO2, SLC6A2, MAOA

GO Terms for genes affiliated with Substance Abuse

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Biological processes related to Substance Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of serotonin secretionGO:0140639.3MAOB, HTR1B
2response to ethanolGO:0454719.2MAOB, HTR1B
3xenobiotic metabolic processGO:0068059.1ADH4, MAOA, MAOB
4response to cocaineGO:0422209.0DRD5, HTR1B
5synaptic transmissionGO:0072688.4SLC6A2, DRD5, MAOA, HTR1B
6small molecule metabolic processGO:0442818.2TDO2, MAOB, MAOA, ADH4

Molecular functions related to Substance Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary amine oxidase activityGO:0081319.6MAOB, MAOA

Products for genes affiliated with Substance Abuse

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  • Antibodies
  • Proteins
  • Lysates

Sources for Substance Abuse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet