MCID: SBS003
MIFTS: 55

Substance Abuse malady

Summaries for Substance Abuse

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning.

MalaCards: Substance Abuse, also known as substance abuse problem, is related to alcohol abuse and personality disorder. An important gene associated with Substance Abuse is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are melatonin degradation II and phenylalanine utilization. The compounds d amphetamine and (+)-butaclamol have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and liver, and related mouse phenotypes are growth/size and behavior/neurological.

CDC:3 (Data are for the U.S.)

Wikipedia:63 Substance abuse, also known as drug abuse, is a patterned use of a substance (drug) in which the user... more...

Aliases & Classifications for Substance Abuse

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

substance abuse 8 10
substance abuse problem 60


External Ids:

Disease Ontology8 DOID:302
NCIt39 C16522
SNOMED-CT56 66214007, 26416006
ICD9CM27 305
MeSH34 D019966

Related Diseases for Substance Abuse

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Substance Abuse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol abuse31.2DRD2, DRD3, ABCB7
2personality disorder31.0HTR1B, DRD2, MAOA, DRD3, MAOB, DRD4
3antisocial personality disorder31.0DRD2, MAOA, HTR1B
4substance dependence30.9DRD5, DRD4, DRD3, DRD2, PDYN
5schizophrenia30.9DRD4, HTR1B, PDYN, DRD2, DRD3, DRD5
6conduct disorder30.7DRD5, MAOA, DRD4, DRD2
7bipolar disorder30.7DRD2, SLC6A2, MAOB, PDYN, MAOA, DRD5
8anxiety disorder30.5DRD2, SLC6A2, MAOA, MAOB
9cocaine abuse30.4DRD2, MOBP
10mood disorder30.4MAOA, DRD4, DRD3, HTR1B, MAOB, SLC6A2
11pathological gambling30.4DRD4, DRD3, DRD2
12alcohol dependence30.4ADH4, MAOA, DRD4, DRD2, HTR1B, GGT2
13dementia30.3MAOA, MAOB
14attention deficit hyperactivity disorder30.2HTR1B, DRD2, SLC6A2, MAOB, MAOA, DRD4
15obesity30.2MAOB, DRD4, DRD2, SLC6A2, ABCB7, MAOA
16generalized anxiety disorder30.2MAOA, SLC6A2
17nicotine dependence30.0DRD2, DRD4
18panic disorder30.0DRD4, MAOA, SLC6A2
19anorexia nervosa30.0DRD4, MAOA, SLC6A2
20schizoaffective disorder30.0DRD3, DRD2, DRD4
21parkinson's disease30.0PDYN, MAOB, DRD3, DRD2, MAOA
22drug dependence30.0OPRL1, PDYN, DRD2, DRD3, MAOA
23opioid abuse10.5
24hepatitis10.5
25hepatitis c10.4
26cannabis abuse10.3
27major depressive disorder10.3
28borderline personality disorder10.3
29hepatitis a10.3
30fetal alcohol syndrome10.2
31eating disorder10.2
32developmental disabilities10.2
33barbiturate abuse10.0
34avoidant personality disorder10.0
35hallucinogen abuse10.0
36cerebritis10.0
37gastroschisis10.0
38somatization disorder10.0
39dependent personality disorder10.0
40multiple personality disorder10.0
41phencyclidine abuse10.0
42frontotemporal dementia10.0
43amphetamine abuse10.0
44antidepressant type abuse10.0
45polyhydramnios10.0
46hepatitis b10.0
47post-traumatic stress disorder10.0
48hepatitis d10.0
49hypercalcemia10.0
50alcohol-related neurodevelopmental disorder10.0

Graphical network of the top 20 diseases related to Substance Abuse:



Diseases related to substance abuse

Clinical Features for Substance Abuse

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Drugs & Therapeutics for Substance Abuse

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Substance Abuse

Drug clinical trials:

Search ClinicalTrials for Substance Abuse

Search NIH Clinical Center for Substance Abuse

Search CenterWatch for Substance Abuse

Genetic Tests for Substance Abuse

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Anatomical Context for Substance Abuse

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32MalaCards
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MalaCards organs/tissues related to Substance Abuse:

32
Testes, Brain, Liver, Cortex, Heart, Kidney, Hypothalamus, Pituitary, Subthalamic nucleus

Animal Models for Substance Abuse or affiliated genes

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Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Substance Abuse:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053789.8HTR1B, DRD2, DRD3, MAMSTR, ABCB7, SLC32A1
2MP:00053869.6DRD3, DRD2, HTR1B, PDYN, MOBP, DRD4
3MP:00036319.5TDO2, MOBP, PDYN, DRD2, DRD3, DRD4
4MP:00053769.4PDYN, DRD2, DRD3, DRD4, OPRL1, MAOA

Publications for Substance Abuse

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50PubMed
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Articles related to Substance Abuse:

(show top 50)    (show all 592)
idTitleAuthorsYear
1
Gender-sensitive substance abuse treatment and arrest outcomes for women. (24209383)
2014
2
A randomized trial of Web-based videoconferencing for substance abuse counseling. (24035556)
2014
3
Does Substance Abuse Fall Exclusively Along the Externalizing Spectrum? (24328838)
2013
4
Brain Potentials Measured During a Go/NoGo Task Predict Completion of Substance Abuse Treatment. (24238783)
2013
5
Weight-related concerns related to drug use for women in substance abuse treatment: prevalence and relationships with eating pathology. (23107389)
2013
6
An HIV prevention intervention for ethnically diverse men in substance abuse treatment: pilot study findings. (23488494)
2013
7
The role of psychopathic traits and substance abuse in predicting violent victimization in patients with schizophrenia spectrum disorders. (24343923)
2013
8
Antisocial personality disorder is associated with receipt of physical disability benefits in substance abuse treatment patients. (23394688)
2013
9
Fecundity of patients with schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, or substance abuse vs their unaffected siblings. (23147713)
2013
10
Substance abuse and pregnancy: "we have a problem". (23314711)
2013
11
The concrete jungle: city stress and substance abuse among young adult African American men. (22739803)
2013
12
Using technology in the delivery of mental health and substance abuse treatment in rural communities: a review. (23093443)
2013
13
Comorbid substance abuse in first-episode schizophrenia: effects on cognition and psychopathology in the EUFEST study. (23537477)
2013
14
The mental health and substance abuse among youths aged 18 to 29: A comparative study. (24083284)
2013
15
Parenting of men with co-occurring intimate partner violence and substance abuse. (23422845)
2013
16
Depression as a mediator of the association between substance abuse and negative parenting of fathers. (22243417)
2012
17
Affective Awareness in Parenting of Fathers with Co-Occurring Substance Abuse and Intimate Partner Violence. (23710257)
2012
18
A snapshot of North Carolina's public mental health, developmental disabilities, and substance abuse service system. (22779165)
2012
19
Relationship of substance abuse to dependence in the U.S. general population. (22456242)
2012
20
Effectiveness of cognitive-behavioral trauma treatment for incarcerated women with mental illnesses and substance abuse disorders. (22858893)
2012
21
Internal and external factors in professional burnout of substance abuse counsellors in Croatia. (22751562)
2012
22
Organizational Readiness for Change in Correctional and Community Substance Abuse Programs. (22505796)
2012
23
Pathways to care: narratives of American Indian adolescents entering substance abuse treatment. (22472275)
2012
24
Employing continuous quality improvement in community-based substance abuse programs. (23276056)
2012
25
Moving beyond access: towards a quality-orientated substance abuse treatment system in South Africa. (22831942)
2012
26
Type of health insurance and the substance abuse treatment gap. (22119184)
2012
27
The effects of relationships with older females on the substance abuse and mental health of adolescent boys. (22352803)
2012
28
Statistical models for longitudinal zero-inflated count data with applications to the substance abuse field. (22826194)
2012
29
Bringing HIV, Substance Abuse and Homelessness into the University of Pennsylvania Anthropology Museum through Photo-Ethnography. (23885347)
2012
30
Challenges and strategies in recruiting, interviewing, and retaining recent Latino immigrants in substance abuse and HIV epidemiologic studies. (22211342)
2012
31
Substance abuse counselor and client reports of mental health screening and enhanced practices. (23025134)
2012
32
Evaluation of an innovative Medicaid health policy initiative to expand substance abuse treatment in Washington State. (22618867)
2012
33
Substance Abuse Recovery after Experiencing Homelessness and Mental Illness: Case Studies of Change Over Time. (22962547)
2012
34
The impact of borderline personality disorder on residential substance abuse treatment dropout among men. (21907503)
2012
35
Physicians in the substance abuse treatment workforce: understanding their employment within publicly funded treatment organizations. (22301083)
2012
36
Vaccines in the Treatment of Substance Abuse. (23472050)
2011
37
Involvement in mental health and substance abuse work: conceptions of service users. (21994839)
2011
38
Overlaps in the nosology of substance abuse and overeating: the translational implications of "food addiction". (21999687)
2011
39
American Indian culture as substance abuse treatment: pursuing evidence for a local intervention. (22400459)
2011
40
The effects of eliminating supplemental security income drug addiction and alcoholism eligibility on the mental health of low-income substance abusers. (20818591)
2010
41
Toward individualized treatment for substance abuse. (22002446)
2010
42
Relationships between parental alcohol abuse and social support, peer substance abuse risk and social support, and substance abuse risk among South Korean adolescents. (19435169)
2009
43
The impact of CYP2D6 and CYP2C19 polymorphisms on suicidal behavior and substance abuse disorder among patients with schizophrenia: a retrospective study. (18520596)
2008
44
Psychiatric and substance dependence comorbidities, sexually transmitted diseases, and risk behaviors among methamphetamine-dependent gay and bisexual men seeking outpatient drug abuse treatment. (12825759)
2003
45
Effect of counselor and client education in nicotine addiction on smoking in substance abusers. (10400284)
1999
46
Growth hormone induced increase in serum IGFBP-3 level is reversed by anabolic steroids in substance abusing power athletes. (9876343)
1998
47
Homovanillic acid and dopamine-beta-hydroxylase in male youth: relationships with paternal substance abuse and antisocial behavior. (7484985)
1995
48
The antecedents of women's crack cocaine abuse: family substance abuse, sexual abuse, depression and illicit drug use. (8246316)
1993
49
Hepatitis D virus antibody in HBsAg-positive and HBsAg-negative substance abusers with chronic liver disease. (3884737)
1985
50
Seizure disorder and substance abuse. (7139454)
1982

Genetic Variations for Substance Abuse

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Expression for genes affiliated with Substance Abuse

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Substance Abuse

Search GEO for disease gene expression data for Substance Abuse.

Pathways for genes affiliated with Substance Abuse

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Sources:
37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 29KEGG, 49PharmGKB, 51QIAGEN
See all sources

Pathways related to Substance Abuse according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4MAOB, MAOA
2
Hide members
10.4MAOB, MAOA
3
Tyrosine metabolism p.1 (dopamine)
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10.4MAOB, MAOA
4
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10.3TDO2, MAOB, MAOA
5
Hide members
10.3MAOA, MAOB, TDO2
6
Hide members
10.3ADH4, MAOB, MAOA
7
Hide members
10.3DRD4, DRD3, DRD2
8
Hide members
10.2MAOB, MAOA, DRD2, PDYN
910.2PDYN, DRD2, MAOA, MAOB
1010.2DRD2, DRD3, DRD4, DRD5
11
Hide members
10.2DRD2, DRD3, DRD4, DRD5
1210.2DRD2, DRD3, DRD4, DRD5
13
Hide members
10.2ADH4, GGT2, MAOB, MAOA
14
Hide members
10.1MAOA, DRD5, DRD4, DRD3, DRD2, HTR1B
15
Hide members
10.0PDYN, HTR1B, DRD2, DRD3, DRD4, DRD5
16
Hide members
10.0HTR1B, DRD2, DRD3, DRD4, DRD5, MAOA

Compounds for genes affiliated with Substance Abuse

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 2BitterDB, 49PharmGKB, 24HMDB
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Compounds related to Substance Abuse according to GeneCards/GeneDecks:

(show top 50)    (show all 192)
idCompoundScoreTop Affiliating Genes
1d amphetamine4410.6MAOB, DRD2, MAOA, SLC6A2
2(+)-butaclamol28 4411.6DRD4, DRD2, DRD5, DRD3
3piribedil28 4411.6DRD3, DRD2, DRD4, MAOB
4rotigotine44 28 1112.6DRD4, DRD3, DRD5, DRD2, MAOB
5benzamide44 211.6DRD3, DRD4, MAOA, DRD2
6methylphenidate44 49 1112.6MAOB, MAOA, DRD5, DRD4, SLC6A2, DRD2
7lisuride28 44 1112.6DRD4, HTR1B, DRD2, DRD3, DRD5
8pergolide28 44 1112.6DRD5, HTR1B, DRD2, DRD3, DRD4
9pramipexole44 49 28 1113.6HTR1B, DRD3, DRD5, DRD2, DRD4
10maoa4410.6SLC6A2, MAOB, DRD4, DRD2, HTR1B, MAOA
11cabergoline28 44 1112.6DRD5, HTR1B, DRD2, DRD4, DRD3
12roxindole28 4411.6DRD4, DRD3, DRD2, HTR1B
13paroxetine44 49 28 1113.6SLC6A2, MAOA, DRD4, DRD3, HTR1B
14aripiprazole28 49 44 11 2414.5DRD3, DRD4, DRD5, DRD2, HTR1B
15ropinirole44 1111.5DRD5, DRD3, MAOB, HTR1B, DRD2, DRD4
16ziprasidone49 28 44 1113.5DRD2, DRD4, DRD3, DRD5, HTR1B
17terguride28 4411.5DRD4, HTR1B, DRD2, DRD3
18piperazine44 1111.5DRD2, DRD3, DRD4, SLC6A2
19apomorphine44 28 1112.5DRD2, DRD4, HTR1B, MAOB, DRD5, DRD3
20amphetamine44 1111.5DRD4, DRD2, PDYN, MAOB, SLC6A2, MAOA
21m-tyramine4410.5SLC6A2, MAOB, MAOA
22spiperone28 4411.5DRD3, DRD2, DRD5, DRD4
23mhpg4410.5DRD4, MAOB, MAOA, SLC6A2
24quetiapine44 49 28 11 2414.5DRD5, HTR1B, DRD3, DRD4, DRD2
25fluoxetine49 44 28 1113.5MAOB, HTR1B, SLC6A2, MAOA, DRD2
26bromocriptine28 44 1112.5HTR1B, DRD2, DRD3, DRD4, DRD5
27methamphetamine44 49 1112.5DRD4, MAOB, SLC6A2, PDYN, MAOA, DRD3
28haloperidol44 28 2 49 1114.5MAOB, SLC6A2, DRD4, DRD3, DRD2, DRD5
296-hydroxydopamine4410.5MAOB, MAOA, DRD4, DRD2, PDYN, DRD3
30chlorpromazine44 28 49 1113.5ABCB7, DRD5, DRD4, DRD3, DRD2
31mptp4410.5DRD2, MAOB, SLC6A2, MAOA, DRD3
32catecholamine4410.5PDYN, DRD3, DRD4, DRD5, MAOA, MAOB
33(-)-sulpiride2810.5DRD4, DRD3, DRD2
34sulpiride44 28 1112.4DRD4, DRD3, DRD2, PDYN
35nicotine44 49 28 1113.4MAOA, DRD3, PDYN, DRD4, SLC6A2, DRD2
36(+)-sulpiride2810.4DRD4, DRD3, DRD2
37levodopa44 1111.4MAOB, DRD5, PDYN, HTR1B, DRD2, DRD3
385-hydroxytryptamine4410.4HTR1B, DRD2, DRD4, OPRL1, MAOA, MAOB
39olanzapine49 44 28 11 2414.4DRD2, DRD4, DRD3, HTR1B, DRD5
40talipexole4410.4DRD3, MAOB, DRD2
41gaba4410.4DRD4, SLC32A1, MAOB, SLC6A2, MAOA, DRD2
42cocaine44 1111.4PDYN, HTR1B, DRD2, DRD3, MOBP, MAOB
43norepinephrine44 11 2412.3MAOA, SLC6A2, MAOB, PDYN, DRD2, DRD3
44cis flupentixol2810.3DRD5, DRD3, DRD2
45Methotrimeprazine1110.3DRD2, DRD5, DRD4, DRD3
46dopamine44 28 11 2413.3SLC6A2, PDYN, DRD5, MAOA, MAOB, SLC32A1
47quinpirole44 2811.2DRD4, DRD3, DRD2, PDYN
48asenapine28 1111.1HTR1B, DRD2, DRD3, DRD4
49glutamate4410.1MAOA, SLC32A1, SLC6A2, ABCB7, MAOB, PDYN
50eticlopride28 4411.0DRD3, DRD4, DRD2

GO Terms for genes affiliated with Substance Abuse

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16Gene Ontology
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Cellular components related to Substance Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.8HTR1B, DRD2, DRD3, DRD4, DRD5, OPRL1
2integral to plasma membraneGO:0058879.7SLC6A2, HTR1B, DRD2, DRD3, DRD4, DRD5

Biological processes related to Substance Abuse according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1response to histamineGO:03477610.7DRD2, DRD3, DRD4
2negative regulation of voltage-gated calcium channel activityGO:190138610.7DRD2, DRD4
3adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.7DRD2, DRD3, DRD4
4regulation of dopamine secretionGO:01405910.7HTR1B, DRD2, DRD3
5negative regulation of dopamine receptor signaling pathwayGO:06016010.7DRD2, DRD3
6dopamine metabolic processGO:04241710.7DRD2, DRD3, DRD4
7negative regulation of protein secretionGO:05070910.6DRD2, DRD3, DRD4
8negative regulation of serotonin secretionGO:01406310.6HTR1B, MAOB
9positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.6DRD2, DRD4
10G-protein coupled receptor internalizationGO:00203110.6HTR1B, DRD2, DRD3
11behavioral response to cocaineGO:04814810.6DRD2, DRD3, DRD4
12arachidonic acid secretionGO:05048210.6DRD2, DRD3, DRD4
13response to cocaineGO:04222010.6DRD5, DRD3, DRD2, HTR1B
14synaptic transmission, dopaminergicGO:00196310.6DRD5, DRD4, DRD3, DRD2
15negative regulation of blood pressureGO:04577610.6DRD2, DRD3, DRD5
16regulation of dopamine uptake involved in synaptic transmissionGO:05158410.6DRD3, DRD2
17negative regulation of adenylate cyclase activityGO:00719410.6DRD4, DRD3, DRD2
18response to amphetamineGO:00197510.6DRD5, DRD4, DRD3, DRD2
19regulation of cAMP metabolic processGO:03081410.6DRD2, DRD3
20behavioral response to ethanolGO:04814910.6DRD4, DRD2
21phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.6DRD5, DRD2
22cellular calcium ion homeostasisGO:00687410.6DRD2, DRD3, DRD4, DRD5
23negative regulation of synaptic transmission, glutamatergicGO:05196710.6HTR1B, DRD2
24xenobiotic metabolic processGO:00680510.5MAOA, MAOB, GGT2, ADH4
25negative regulation of cAMP biosynthetic processGO:03081810.5HTR1B, DRD4
26response to ethanolGO:04547110.5MAOB, DRD3, HTR1B
27adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.5DRD3, DRD5
28synaptic transmissionGO:00726810.4PDYN, HTR1B, DRD5, MAOA, SLC32A1, SLC6A2
29prepulse inhibitionGO:06013410.4DRD3, DRD2
30associative learningGO:00830610.4DRD5, DRD2
31positive regulation of renal sodium excretionGO:03581510.3DRD2, DRD3
32circadian regulation of gene expressionGO:03292210.2DRD2, DRD3
33positive regulation of neuroblast proliferationGO:00205210.0OTP, DRD2

Molecular functions related to Substance Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary amine oxidase activityGO:00813110.4MAOB, MAOA
2dopamine bindingGO:03524010.3DRD5, DRD4, DRD3, DRD2
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.3DRD4, DRD3, DRD2
4drug bindingGO:00814410.1HTR1B, DRD2, DRD3, DRD4
5dopamine neurotransmitter receptor activityGO:00495210.0DRD5, DRD4

Products for genes affiliated with Substance Abuse

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Substance Abuse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet