MCID: SBS003
MIFTS: 55

Substance Abuse malady

Summaries for Substance Abuse

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning.

MalaCards: Substance Abuse, also known as substance abuse problem, is related to alcohol abuse and antisocial personality disorder. An important gene associated with Substance Abuse is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are melatonin degradation II and phenylalanine utilization. The compounds d amphetamine and (+)-butaclamol have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related mouse phenotypes are growth/size and behavior/neurological.

CDC:3 (Data are for the U.S.)

Wikipedia:64 Substance abuse, also known as drug abuse, is a patterned use of a substance (drug) in which the user... more...

Aliases & Classifications for Substance Abuse

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 40NCIt, 57SNOMED-CT, 27ICD9CM, 35MeSH
See all sources

Aliases & Descriptions:

substance abuse 8 10
substance abuse problem 61


External Ids:

Disease Ontology8 DOID:302
NCIt40 C16522
SNOMED-CT57 66214007, 26416006
ICD9CM27 305
MeSH35 D019966

Related Diseases for Substance Abuse

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Substance Abuse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol abuse31.2DRD2, DRD3, ABCB7
2antisocial personality disorder31.0DRD2, MAOA, HTR1B
3substance dependence30.9DRD5, DRD4, DRD3, DRD2, PDYN
4conduct disorder30.8DRD5, MAOA, DRD4, DRD2
5bipolar disorder30.7DRD2, SLC6A2, MAOB, PDYN, MAOA, DRD5
6drug addiction30.6DRD2, PDYN, DRD3
7anxiety disorder30.6DRD2, SLC6A2, MAOA, MAOB
8cocaine abuse30.5DRD2, MOBP
9pathological gambling30.4DRD4, DRD3, DRD2
10alcohol dependence30.4ADH4, MAOA, DRD4, DRD2, HTR1B, GGT2
11attention deficit hyperactivity disorder30.3HTR1B, DRD2, SLC6A2, MAOB, MAOA, DRD4
12generalized anxiety disorder30.3MAOA, SLC6A2
13nicotine dependence30.1DRD2, DRD4
14panic disorder30.1DRD4, MAOA, SLC6A2
15anorexia nervosa30.0DRD4, MAOA, SLC6A2
16schizoaffective disorder30.0DRD3, DRD2, DRD4
17huntington's disease30.0DRD2
18parkinson's disease30.0PDYN, MAOB, DRD3, DRD2, MAOA
19opioid abuse10.5
20hepatitis a10.5
21hepatitis c10.4
22cannabis abuse10.4
23hepatitis d10.4
24nicotine addiction10.4
25borderline personality disorder10.3
26bipolar i disorder10.3
27hepatitis e10.2
28fetal alcohol syndrome10.2
29n syndrome10.2
30developmental disabilities10.2
31barbiturate abuse10.1
32hallucinogen abuse10.1
33neurotic excoriation10.1
34gastroschisis10.1
35somatization disorder10.1
36multiple personality disorder10.1
37phencyclidine abuse10.1
38frontotemporal dementia10.1
39amphetamine abuse10.1
40antidepressant type abuse10.1
41polyhydramnios10.1
42post-traumatic stress disorder10.1
43hypercalcemia10.1
44alcohol-related neurodevelopmental disorder10.1
45asthma10.1
46botulism10.1
47brain disease10.1
48sleep disorder10.1
49tuberculosis10.1
50non-a-e hepatitis10.1

Graphical network of the top 20 diseases related to Substance Abuse:



Diseases related to substance abuse

Clinical Features for Substance Abuse

Drugs & Therapeutics for Substance Abuse

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Substance Abuse

Drug clinical trials:

Search ClinicalTrials for Substance Abuse

Search NIH Clinical Center for Substance Abuse

Search CenterWatch for Substance Abuse

Genetic Tests for Substance Abuse

Anatomical Context for Substance Abuse

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Substance Abuse:

33
Brain, Cortex, Heart, Kidney, Liver, Fetal brain, Hypothalamus, Subthalamic nucleus, Fetal liver, Adrenal cortex, Pituitary

Animal Models for Substance Abuse or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Substance Abuse

Sources:
51PubMed
See all sources

Articles related to Substance Abuse:

(show top 50)    (show all 590)
idTitleAuthorsYear
1
The tangled branches (las ramas enredadas): sexual risk, substance abuse, and intimate partner violence among Hispanic men who have sex with men. (24084703)
2014
2
Referral for substance abuse treatment and depression improvement among patients with co-occurring disorders seeking behavioral health services in primary care. (24095002)
2014
3
Characterizing smoking, cessation services, and quit interest across outpatient substance abuse treatment modalities. (23988192)
2014
4
Veterans' attitudes toward work and disability compensation: associations with substance abuse. (24090622)
2014
5
Adoption and diffusion of evidence-based addiction medications in substance abuse treatment. (23855719)
2014
6
Overdose prevention in injecting opioid users: The role of substance abuse treatment and training programs. (24418018)
2014
7
Engagement in outpatient substance abuse treatment and employment outcomes. (23686216)
2014
8
Pilot evaluation of a substance abuse prevention group intervention for at-risk bariatric surgery candidates. (23473996)
2013
9
Substance abuse treatment implementation research. (23083972)
2013
10
The use and costs of health and social services in patients with longstanding substance abuse. (23692822)
2013
11
A Unique Model for Treating Chronic Hepatitis C in Patients With Psychiatric Disorders, Substance Abuse, and/or Housing Instability. (23896750)
2013
12
Sometimes you just have to have a lot of bitter to make it sweet: Substance abuse and partner abuse in the lives of HIV+ men who have sex with men. (24163573)
2013
13
Addiction research centres and the nurturing of creativity: The Alcohol & Drug Abuse Research Unit at the South African Medical Research Council - strengthening substance abuse research and policy in South Africa. (22029284)
2013
14
The investigation of tramadol dependence with no history of substance abuse: a cross-sectional survey of spontaneously reported cases in Guangzhou City, China. (24151592)
2013
15
Does substance abuse contribute to further risk of falls in dementia. (23883099)
2013
16
Disparities in completion of substance abuse treatment between and within racial and ethnic groups. (23350871)
2013
17
Contribution of psychiatric illness and substance abuse to 30-day readmission risk. (23589474)
2013
18
The influence of maternal optimality and infant temperament on parenting stress at 12 months among mothers with substance abuse and psychiatric problems. (24004246)
2013
19
Prevalence of hospitalized live births affected by alcohol and drugs and parturient women diagnosed with substance abuse at liveborn delivery: United States, 1999-2008. (22688539)
2013
20
Evaluation of a suicide prevention training curriculum for substance abuse treatment providers based on Treatment Improvement Protocol Number 50. (22417671)
2013
21
Negative dimension in psychiatry. Amotivational syndrome as a paradigm of negative symptoms in substance abuse. (23438696)
2013
22
Community capacity assessment in preventing substance abuse: a participatory approach. (23193506)
2012
23
How to measure outcome in clinical trials of substance abuse treatment. (22372699)
2012
24
Low and moderate alcohol consumption during pregnancy: effects on social behaviour and propensity to develop substance abuse in later life. (23164117)
2012
25
Validation of the substance abuse screener in American Sign Language (SAS--ASL). (22686552)
2012
26
Genetic modulation of plasma NPY stress response is suppressed in substance abuse: association with clinical outcomes. (21917383)
2012
27
Substance abuse in high school students in association with socio-demographic variables in northwest of iran. (23641389)
2012
28
Spending trends on substance abuse treatment under private employer-sponsored insurance, 2001-2009. (22436972)
2012
29
The need to identify and effectively manage nutritional concerns in patients undergoing treatment for substance abuse. (22459554)
2012
30
Mirtazapine, and mirtazapine-like compounds as possible pharmacotherapy for substance abuse disorders: evidence from the bench and the bedside. (22960395)
2012
31
Hepatitis B virus and hepatitis C virus services offered by substance abuse treatment programs in the United States. (22035702)
2012
32
Anthropological perspectives on money management: considerations for the design and implementation of interventions for substance abuse. (22175806)
2012
33
Medical marijuana use among adolescents in substance abuse treatment. (22721592)
2012
34
Substance abuse, HIV-1 and hepatitis. (22973853)
2012
35
Integrated programs for mothers with substance abuse issues: A systematic review of studies reporting on parenting outcomes. (22429792)
2012
36
Adolescents' experiences of a strengths-based treatment program for substance abuse. (23457890)
2012
37
On-site provision of substance abuse treatment services at community health centers. (22116010)
2012
38
Risk factors for criminal recidivism - a prospective follow-up study in prisoners with substance abuse. (22894706)
2012
39
Models of neurological disease (substance abuse): self-administration in monkeys. (22382996)
2011
40
The substance abuse counseling workforce: education, preparation, and certification. (22014248)
2011
41
Addiction medicine and substance abuse care. (22084471)
2011
42
Factors associated with medication adherence among psychiatric outpatients at substance abuse risk. (23264842)
2011
43
Parent training with behavioral couples therapy for fathers' alcohol abuse: effects on substance use, parental relationship, parenting, and CPS involvement. (19502478)
2009
44
Antisocial personality disorder as a predictor of criminal behaviour in a longitudinal study of a cohort of abusers of several classes of drugs: relation to type of substance and type of crime. (18258375)
2008
45
Prospective effects of attention-deficit/hyperactivity disorder, conduct disorder, and sex on adolescent substance use and abuse. (17909126)
2007
46
The relation between attention deficit hyperactivity disorder and substance abuse: what role does conduct disorder play? (12659448)
2003
47
Discounting of delayed rewards in substance abusers: relationship to antisocial personality disorder. (12172697)
2002
48
HIV risk behaviors in male substance abusers with and without antisocial personality disorder. (10867302)
2000
49
Cognitive-neuromotor assessment of substance abuse: focus on issues related to cocaine abuse treatment. (9467799)
1997
50
Antisocial personality disorder in patients with substance abuse disorders: a problematic diagnosis? (2405719)
1990

Genetic Variations for Substance Abuse

Expression for genes affiliated with Substance Abuse

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Substance Abuse

Search GEO for disease gene expression data for Substance Abuse.

Pathways for genes affiliated with Substance Abuse

Sources:
38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 30KEGG, 50PharmGKB, 52QIAGEN
See all sources

Pathways related to Substance Abuse according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4MAOB, MAOA
2
Hide members
10.4MAOB, MAOA
3
Tyrosine metabolism p.1 (dopamine)
Hide members
10.4MAOB, MAOA
4
Hide members
10.3TDO2, MAOB, MAOA
5
Hide members
10.3MAOA, MAOB, TDO2
6
Hide members
10.3ADH4, MAOB, MAOA
7
Hide members
10.3DRD4, DRD3, DRD2
8
Hide members
10.2MAOB, MAOA, DRD2, PDYN
910.2PDYN, DRD2, MAOA, MAOB
1010.2DRD2, DRD3, DRD4, DRD5
11
Hide members
10.2DRD2, DRD3, DRD4, DRD5
1210.2DRD2, DRD3, DRD4, DRD5
13
Hide members
10.2ADH4, GGT2, MAOB, MAOA
14
Hide members
10.1MAOA, DRD5, DRD4, DRD3, DRD2, HTR1B
15
Hide members
10.0PDYN, HTR1B, DRD2, DRD3, DRD4, DRD5
16
Hide members
10.0HTR1B, DRD2, DRD3, DRD4, DRD5, MAOA

Compounds for genes affiliated with Substance Abuse

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 2BitterDB, 50PharmGKB, 24HMDB
See all sources

Compounds related to Substance Abuse according to GeneCards/GeneDecks:

(show top 50)    (show all 192)
idCompoundScoreTop Affiliating Genes
1d amphetamine4510.6MAOB, DRD2, MAOA, SLC6A2
2(+)-butaclamol29 4511.6DRD4, DRD2, DRD5, DRD3
3piribedil29 4511.6DRD3, DRD2, DRD4, MAOB
4rotigotine45 29 1112.6DRD4, DRD3, DRD5, DRD2, MAOB
5benzamide45 211.6DRD3, DRD4, MAOA, DRD2
6methylphenidate45 50 1112.6MAOB, MAOA, DRD5, DRD4, SLC6A2, DRD2
7lisuride29 45 1112.6DRD4, HTR1B, DRD2, DRD3, DRD5
8pergolide29 45 1112.6DRD5, HTR1B, DRD2, DRD3, DRD4
9pramipexole45 50 29 1113.6HTR1B, DRD3, DRD5, DRD2, DRD4
10maoa4510.6SLC6A2, MAOB, DRD4, DRD2, HTR1B, MAOA
11cabergoline29 45 1112.6DRD5, HTR1B, DRD2, DRD4, DRD3
12roxindole29 4511.6DRD4, DRD3, DRD2, HTR1B
13paroxetine45 50 29 1113.6SLC6A2, MAOA, DRD4, DRD3, HTR1B
14aripiprazole29 50 45 11 2414.5DRD3, DRD4, DRD5, DRD2, HTR1B
15ropinirole45 1111.5DRD5, DRD3, MAOB, HTR1B, DRD2, DRD4
16ziprasidone50 29 45 1113.5DRD2, DRD4, DRD3, DRD5, HTR1B
17terguride29 4511.5DRD4, HTR1B, DRD2, DRD3
18piperazine45 1111.5DRD2, DRD3, DRD4, SLC6A2
19apomorphine45 29 1112.5DRD2, DRD4, HTR1B, MAOB, DRD5, DRD3
20amphetamine45 1111.5DRD4, DRD2, PDYN, MAOB, SLC6A2, MAOA
21m-tyramine4510.5SLC6A2, MAOB, MAOA
22spiperone29 4511.5DRD3, DRD2, DRD5, DRD4
23mhpg4510.5DRD4, MAOB, MAOA, SLC6A2
24quetiapine45 50 29 11 2414.5DRD5, HTR1B, DRD3, DRD4, DRD2
25fluoxetine50 45 29 1113.5MAOB, HTR1B, SLC6A2, MAOA, DRD2
26bromocriptine29 45 1112.5HTR1B, DRD2, DRD3, DRD4, DRD5
27methamphetamine45 50 1112.5DRD4, MAOB, SLC6A2, PDYN, MAOA, DRD3
28haloperidol45 29 2 50 1114.5MAOB, SLC6A2, DRD4, DRD3, DRD2, DRD5
296-hydroxydopamine4510.5MAOB, MAOA, DRD4, DRD2, PDYN, DRD3
30chlorpromazine45 29 50 1113.5ABCB7, DRD5, DRD4, DRD3, DRD2
31mptp4510.5DRD2, MAOB, SLC6A2, MAOA, DRD3
32catecholamine4510.5PDYN, DRD3, DRD4, DRD5, MAOA, MAOB
33(-)-sulpiride2910.5DRD4, DRD3, DRD2
34sulpiride45 29 1112.4DRD4, DRD3, DRD2, PDYN
35nicotine45 50 29 1113.4MAOA, DRD3, PDYN, DRD4, SLC6A2, DRD2
36(+)-sulpiride2910.4DRD4, DRD3, DRD2
37levodopa45 1111.4MAOB, DRD5, PDYN, HTR1B, DRD2, DRD3
385-hydroxytryptamine4510.4HTR1B, DRD2, DRD4, OPRL1, MAOA, MAOB
39olanzapine50 45 29 11 2414.4DRD2, DRD4, DRD3, HTR1B, DRD5
40talipexole4510.4DRD3, MAOB, DRD2
41gaba4510.4DRD4, SLC32A1, MAOB, SLC6A2, MAOA, DRD2
42cocaine45 1111.4PDYN, HTR1B, DRD2, DRD3, MOBP, MAOB
43norepinephrine45 11 2412.3MAOA, SLC6A2, MAOB, PDYN, DRD2, DRD3
44cis flupentixol2910.3DRD5, DRD3, DRD2
45Methotrimeprazine1110.3DRD2, DRD5, DRD4, DRD3
46dopamine45 29 11 2413.3SLC6A2, PDYN, DRD5, MAOA, MAOB, SLC32A1
47quinpirole45 2911.2DRD4, DRD3, DRD2, PDYN
48asenapine29 1111.1HTR1B, DRD2, DRD3, DRD4
49glutamate4510.1MAOA, SLC32A1, SLC6A2, ABCB7, MAOB, PDYN
50eticlopride29 4511.0DRD3, DRD4, DRD2

GO Terms for genes affiliated with Substance Abuse

Sources:
16Gene Ontology
See all sources

Cellular components related to Substance Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.8PDYN, HTR1B, DRD2, DRD3, DRD4, DRD5
2integral to plasma membraneGO:0058879.7HTR1B, DRD2, DRD3, DRD4, DRD5, OPRL1

Biological processes related to Substance Abuse according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1response to histamineGO:03477610.7DRD2, DRD3, DRD4
2negative regulation of voltage-gated calcium channel activityGO:190138610.7DRD2, DRD4
3adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.7DRD2, DRD3, DRD4
4regulation of dopamine secretionGO:01405910.7HTR1B, DRD2, DRD3
5negative regulation of dopamine receptor signaling pathwayGO:06016010.7DRD2, DRD3
6dopamine metabolic processGO:04241710.7DRD2, DRD3, DRD4
7negative regulation of protein secretionGO:05070910.6DRD2, DRD3, DRD4
8negative regulation of serotonin secretionGO:01406310.6HTR1B, MAOB
9positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.6DRD2, DRD4
10G-protein coupled receptor internalizationGO:00203110.6HTR1B, DRD2, DRD3
11behavioral response to cocaineGO:04814810.6DRD2, DRD3, DRD4
12arachidonic acid secretionGO:05048210.6DRD2, DRD3, DRD4
13response to cocaineGO:04222010.6DRD5, DRD3, DRD2, HTR1B
14synaptic transmission, dopaminergicGO:00196310.6DRD5, DRD4, DRD3, DRD2
15negative regulation of blood pressureGO:04577610.6DRD2, DRD3, DRD5
16regulation of dopamine uptake involved in synaptic transmissionGO:05158410.6DRD3, DRD2
17negative regulation of adenylate cyclase activityGO:00719410.6DRD4, DRD3, DRD2
18response to amphetamineGO:00197510.6DRD5, DRD4, DRD3, DRD2
19regulation of cAMP metabolic processGO:03081410.6DRD2, DRD3
20behavioral response to ethanolGO:04814910.6DRD4, DRD2
21phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.6DRD5, DRD2
22cellular calcium ion homeostasisGO:00687410.6DRD2, DRD3, DRD4, DRD5
23negative regulation of synaptic transmission, glutamatergicGO:05196710.6HTR1B, DRD2
24xenobiotic metabolic processGO:00680510.5MAOA, MAOB, GGT2, ADH4
25negative regulation of cAMP biosynthetic processGO:03081810.5HTR1B, DRD4
26response to ethanolGO:04547110.5MAOB, DRD3, HTR1B
27adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.5DRD3, DRD5
28synaptic transmissionGO:00726810.4PDYN, HTR1B, DRD5, MAOA, SLC32A1, SLC6A2
29prepulse inhibitionGO:06013410.4DRD3, DRD2
30associative learningGO:00830610.4DRD5, DRD2
31positive regulation of renal sodium excretionGO:03581510.3DRD2, DRD3
32circadian regulation of gene expressionGO:03292210.2DRD2, DRD3
33positive regulation of neuroblast proliferationGO:00205210.0OTP, DRD2

Molecular functions related to Substance Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary amine oxidase activityGO:00813110.4MAOA, MAOB
2dopamine bindingGO:03524010.3DRD2, DRD3, DRD4, DRD5
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.3DRD4, DRD3, DRD2
4drug bindingGO:00814410.1DRD4, HTR1B, DRD2, DRD3
5dopamine neurotransmitter receptor activityGO:00495210.0DRD5, DRD4

Products for genes affiliated with Substance Abuse

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Substance Abuse

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet