MCID: SBS003
MIFTS: 49

Substance Abuse malady

Mental diseases category

Summaries for Substance Abuse

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Sources:
9Disease Ontology, 4CDC, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning.

MalaCards: Substance Abuse, also known as substance abuse problem, is related to antisocial personality disorder and personality disorder. An important gene associated with Substance Abuse is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are Histidine metabolism and Tyrosine metabolism p.1 dopamine . The compounds (r)-(-)-deprenyl hydrochloride and phenethylamine, have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and liver, and related mouse phenotypes are nervous system and behavior/neurological.

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Wikipedia:66 Substance abuse, also known as drug abuse, is a patterned use of a substance (drug) in which the user... more...

Aliases & Classifications for Substance Abuse

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 28ICD9CM, 41NCIt, 36MeSH, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

substance abuse 9 11
substance abuse problem 63


External Ids:

Disease Ontology9 DOID:302
ICD9CM28 305
SNOMED-CT59 66214007, 26416006
NCIt41 C16522
MeSH36 D019966

Related Diseases for Substance Abuse

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Substance Abuse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1antisocial personality disorder31.1HTR1B, MAOA
2personality disorder31.0MAOB, HTR1B, MAOA
3conduct disorder30.9MAOA, DRD5
4anxiety disorder30.8MAOA
5schizophrenia30.7MAOB, TDO2, SLC6A2, DRD5, HTR1B, MAOA
6bipolar disorder30.7SLC6A2, MAOA, MAOB, DRD5
7mood disorder30.4SLC6A2, MAOA, HTR1B, MAOB
8generalized anxiety disorder30.4MAOA, SLC6A2
9borderline personality disorder30.3MAOA, HTR1B
10obesity30.3MAOA, MAOB, SLC6A2
11attention deficit hyperactivity disorder30.2DRD5, HTR1B, SLC6A2, MAOA
12panic disorder30.1MAOA, SLC6A2
13anorexia nervosa30.1SLC6A2, MAOA
14alcohol dependence30.0MAOA, HTR1B, ADH4
15parkinson's disease30.0HTR1B, SLC6A2, MAOB, MAOA
16cannabis abuse10.5
17hepatitis10.5
18alcohol abuse10.4
19hiv/aids10.4
20hepatitis c10.4
21drug addiction10.4
22nicotine addiction10.4
23cocaine abuse10.3
24pathological gambling10.3
25dementia10.3
26opioid abuse10.2
27fetal alcohol syndrome10.2
28eating disorder10.2
29substance dependence10.2
30developmental disabilities10.2
31oppositional defiant disorder10.1SLC6A2
32agoraphobia10.1SLC6A2, MAOA
33multiple personality disorder10.1
34phencyclidine abuse10.1
35frontotemporal dementia10.1
36amphetamine abuse10.1
37antidepressant type abuse10.1
38polyhydramnios10.1
39schizoaffective disorder10.1
40barbiturate abuse10.1
41post-traumatic stress disorder10.1
42hepatitis b10.1
43hepatitis d10.1
44hypercalcemia10.1
45hallucinogen abuse10.1
46cerebritis10.1
47alcohol-related neurodevelopmental disorder10.1
48neurotic excoriation10.1
49gastroschisis10.1
50somatization disorder10.1

Graphical network of the top 20 diseases related to Substance Abuse:



Diseases related to substance abuse

Symptoms for Substance Abuse

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Drugs & Therapeutics for Substance Abuse

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Substance Abuse

Drug clinical trials:

Search ClinicalTrials for Substance Abuse

Search NIH Clinical Center for Substance Abuse

Search CenterWatch for Substance Abuse

Genetic Tests for Substance Abuse

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Anatomical Context for Substance Abuse

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Sources:
34MalaCards
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MalaCards organs/tissues related to Substance Abuse:

34
Testes, Brain, Liver, Heart, Kidney, Hypothalamus, Pituitary, Subthalamic nucleus

Animal Models for Substance Abuse or affiliated genes

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Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Substance Abuse:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.1MAOB, DRD5, TDO2, SLC6A2, MAOA
2MP:00053867.5SLC6A2, TDO2, MAOB, MAOA, HTR1B

Publications for Substance Abuse

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Sources:
53PubMed
See all sources

Articles related to Substance Abuse:

(show top 50)    (show all 554)
idTitleAuthorsYear
1
Service utilization of asians and other racial-ethnic groups: comparisons in a state substance abuse treatment system. (24093520)
2014
2
Criminal justice outcomes after engagement in outpatient substance abuse treatment. (24238717)
2014
3
The tangled branches (las ramas enredadas): sexual risk, substance abuse, and intimate partner violence among Hispanic men who have sex with men. (24084703)
2014
4
Referral for substance abuse treatment and depression improvement among patients with co-occurring disorders seeking behavioral health services in primary care. (24095002)
2014
5
The Relationship of State Medicaid Coverage to Medicaid Acceptance Among Substance Abuse Providers in the United States. (24407938)
2014
6
A review of existing treatments for substance abuse among the elderly and recommendations for future directions. (23471422)
2013
7
How the states stack up: disparities in substance abuse outpatient treatment completion rates for minorities. (23664124)
2013
8
Approaches to substance abuse in Cuba: Ricardo A. GonzA!lez MD PhD DrSc. Psychiatrist and consulting professor, Eduardo B. Ordaz. Psychiatric Hospital, Havana. Interviewed by Christina Mills. (24253343)
2013
9
Utilization of communication technology by patients enrolled in substance abuse treatment. (23107600)
2013
10
Substance abuse journal: new beginnings. (24159902)
2013
11
Future research needs for evaluating the integration of mental health and substance abuse treatment with primary care. (24042241)
2013
12
Substance use among women receiving post-rape medical care, associated post-assault concerns and current substance abuse: results from a national telephone household probability sample. (23380490)
2013
13
Work needed to close gaps in coverage for mental health, substance abuse treatment. (24386795)
2013
14
Does Substance Abuse Fall Exclusively Along the Externalizing Spectrum? (24328838)
2013
15
The provider perception inventory: psychometrics of a scale designed to measure provider stigma about HIV, substance abuse, and MSM behavior. (23082899)
2013
16
Gene-environment correlation in the development of adolescent substance abuse: selection effects of child personality and mediation via contextual risk factors. (23398757)
2013
17
Employment status of veterans receiving substance abuse treatment from the U.S. Department of Veterans Affairs. (23370624)
2013
18
Predictors of retention in a drug-free unit/substance abuse treatment in prison. (23706657)
2013
19
Substance screening and referral for substance abuse treatment in an integrated mental health care program. (23280462)
2013
20
Substance abuse as a risk factor for violence in mental illness: some implications for forensic psychiatric practice and clinical ethics. (23722099)
2013
21
Pilot evaluation of a substance abuse prevention group intervention for at-risk bariatric surgery candidates. (23473996)
2013
22
Substance abuse and smoking among a Canadian cohort of first episode psychosis patients. (23775243)
2013
23
Substance Abuse Treatment, HIV/AIDS, and the Continuum of Response for People Who Inject Drugs. (23243517)
2012
24
Depression as a mediator of the association between substance abuse and negative parenting of fathers. (22243417)
2012
25
Affective Awareness in Parenting of Fathers with Co-Occurring Substance Abuse and Intimate Partner Violence. (23710257)
2012
26
Organizational consequences of staff turnover in outpatient substance abuse treatment programs. (22154028)
2012
27
Changing pattern of substance abuse in patients attending a de-addiction centre in north India (1978-2008). (22825602)
2012
28
Substance abuse among migrant workers of Thai-Laos border, Thailand. (23140041)
2012
29
Community capacity assessment in preventing substance abuse: a participatory approach. (23193506)
2012
30
How to measure outcome in clinical trials of substance abuse treatment. (22372699)
2012
31
Culturally competent substance abuse treatment with transgender persons. (22873185)
2012
32
Substance abuse and movement disorders: complex interactions and comorbidities. (23030352)
2012
33
The dangers of substance abuse in adolescents with chronic kidney disease: a review of the literature. (22558679)
2012
34
A snapshot of North Carolina's public mental health, developmental disabilities, and substance abuse service system. (22779165)
2012
35
Disparities in completion of substance abuse treatment among Latino subgroups in Los Angeles County, CA. (22658303)
2012
36
Chronic illness histories of adults entering treatment for co-occurring substance abuse and other mental health disorders. (22211340)
2012
37
Resources and training in outpatient substance abuse treatment facilities. (22154031)
2012
38
Relationship of substance abuse to dependence in the U.S. general population. (22456242)
2012
39
Using the theory of planned behavior to examine residential substance abuse workers intention to use evidence-based practices. (22686963)
2012
40
Low and moderate alcohol consumption during pregnancy: effects on social behaviour and propensity to develop substance abuse in later life. (23164117)
2012
41
Substance abuse prevalence and its relation to scholastic achievement and sport factors: an analysis among adolescents of the Herzegovina-Neretva Canton in Bosnia and Herzegovina. (22480230)
2012
42
Family treatment for bipolar disorder and substance abuse in late adolescence. (22504610)
2012
43
Models of neurological disease (substance abuse): self-administration in monkeys. (22382996)
2011
44
Increasing ethnic minority participation in substance abuse clinical trials: lessons learned in the National Institute on Drug Abuse's Clinical Trials Network. (21988575)
2011
45
Editors' introduction: Identifying and assessing promising practices for criminal justice clients--California Substance Abuse Research Consortium (SARC) meetings, 2010. (22185034)
2011
46
Gender differences and conduct disorder among American Indian adolescents in substance abuse treatment. (12733762)
2003
47
Diagnosing antisocial personality disorder among substance abusers: the scid versus the MCMI-II. (11727884)
2001
48
A functionally deficient DRD2 variant [Ser311Cys] is not linked to alcoholism and substance abuse. (9650635)
1998
49
Substance abuse vulnerability and D2 receptor genes. (7681236)
1993
50
The antecedents of women's crack cocaine abuse: family substance abuse, sexual abuse, depression and illicit drug use. (8246316)
1993

Variations for Substance Abuse

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Expression for genes affiliated with Substance Abuse

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Substance Abuse

Search GEO for disease gene expression data for Substance Abuse.

Pathways for genes affiliated with Substance Abuse

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Sources:
51PathCards, 31KEGG, 56Reactome, 39NCBI BioSystems Database, 61Thomson Reuters, 52PharmGKB
See all sources

Pathways related to Substance Abuse according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
histamine biosynthesis39
9.6MAOB, MAOA
29.6MAOB, MAOA
3
Show member pathways
choline degradation I39
glycine biosynthesis III39
serine and glycine biosynthesis39
glycine betaine degradation39
glycine biosynthesis39
9.6MAOA, MAOB
4
Show member pathways
citrulline-nitric oxide cycle39
arginine degradation I (arginase pathway)39
proline degradation39
glutamine degradation I39
proline biosynthesis I39
superpathway of citrulline metabolism39
proline biosynthesis II (from arginine)39
citrulline biosynthesis39
arginine degradation VI (arginase 2 pathway)39
Urea cycle and metabolism of amino groups39
asparagine biosynthesis I39
4-hydroxyproline degradation I39
citrulline degradation39
9.6MAOB, MAOA
5
Show member pathways
9.6MAOA, MAOB
69.6MAOA, MAOB
79.6MAOB, MAOA
89.6MAOA, MAOB
99.2MAOA, HTR1B
10
Show member pathways
9.1DRD5, HTR1B
11
Show member pathways
phenylalanine utilization39
noradrenaline and adrenaline degradation39
phenylalanine degradation IV39
9.1ADH4, MAOA, MAOB
12
Show member pathways
9.1MAOB, MAOA, ADH4
13
Show member pathways
9.1MAOB, MAOA, ADH4
14
Show member pathways
9.1ADH4, MAOA, MAOB
15
Show member pathways
Serotonin Transporter Activity39
9.1SLC6A2, TDO2, MAOA
16
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)39
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA39
tryptophan degradation39
glutaryl-CoA degradation39
serotonin degradation39
NAD de novo biosynthesis39
superpathway of melatonin degradation39
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde39
tryptophan utilization I39
melatonin degradation I39
9.0TDO2, MAOB, MAOA
17
Show member pathways
9.0TDO2, MAOB, MAOA
18
Show member pathways
8.5TDO2, MAOB, MAOA, ADH4
19
Show member pathways
8.3HTR1B, MAOA, MAOB, DRD5

Compounds for genes affiliated with Substance Abuse

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Sources:
62Tocris Bioscience, 46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 52PharmGKB
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Compounds related to Substance Abuse according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1(r)-(-)-deprenyl hydrochloride6210.0MAOA, MAOB
2phenethylamine,4610.0MAOA, MAOB
3brofaromine4610.0MAOA, MAOB
4pirlindole469.9MAOA, MAOB
51-methyl-4-phenyl-2,3-dihydropyridinium469.9MAOA, MAOB
6toloxatone469.9MAOA, MAOB
7pyrazoline469.9MAOA, MAOB
8bifemelane hydrochloride629.9MAOB, MAOA
94,6-Dihydroxyquinoline259.9MAOA, MAOB
10isocarboxazid46 1210.9MAOA, MAOB
11iproniazid46 1210.9MAOB, MAOA
12rasagiline mesylate629.9MAOA, MAOB
13lazabemide hydrochloride629.9MAOA, MAOB
141,4-diphenyl-2-butene469.8MAOA, MAOB
15lazabemide469.8MAOB, MAOA
16m-tyramine469.7MAOA, MAOB, SLC6A2
17p-chloroamphetamine469.7MAOA, SLC6A2, MAOB
18nomifensine46 30 1211.7MAOA, SLC6A2, MAOB
19phentermine46 1210.7MAOA, SLC6A2, MAOB
20d amphetamine469.7MAOB, MAOA, SLC6A2
21mdma469.7MAOA, MAOB, SLC6A2
22mhpg469.7MAOA, SLC6A2, MAOB
23homovanillic acid46 2510.6MAOB, MAOA, SLC6A2
241 methyl 4 phenylpyridinium469.6SLC6A2, MAOA, MAOB
25sertraline46 30 52 25 1213.6SLC6A2, MAOA, MAOB
265-hydroxyindoleacetic acid46 2510.6SLC6A2, MAOB, MAOA
27tyramine46 30 2511.6SLC6A2, MAOB, MAOA
28harman469.6MAOB, MAOA
29amitriptyline46 30 52 1212.6MAOA, SLC6A2, MAOB
30methamphetamine46 52 1211.4MAOA, MAOB, SLC6A2
316-hydroxydopamine469.4MAOA, SLC6A2, MAOB
32amphetamine46 52 1211.3SLC6A2, MAOB, MAOA
33milacemide469.3MAOB, MAOA
34citalopram46 52 25 1212.3MAOB, SLC6A2, MAOA
35clomipramine46 52 1211.2HTR1B, SLC6A2, MAOA
36paroxetine46 52 30 1212.2SLC6A2, HTR1B, MAOA
37mptp469.2MAOA, MAOB, SLC6A2
38tryptamine46 30 2511.2MAOB, HTR1B, MAOA
39Serotonin259.2MAOA, MAOB, HTR1B
40methylphenidate46 52 1211.2MAOB, SLC6A2, DRD5, MAOA
41catecholamine469.1MAOB, DRD5, SLC6A2, MAOA
42ropinirole46 1210.1DRD5, HTR1B, MAOB
43apomorphine30 46 1211.0MAOB, HTR1B, DRD5
44maoa468.9MAOB, MAOA, HTR1B, SLC6A2
45fluoxetine46 52 30 1211.9SLC6A2, MAOB, HTR1B, MAOA
46amine468.8MAOA, SLC6A2, MAOB, HTR1B
47levodopa46 129.7MAOA, HTR1B, MAOB, DRD5
48norepinephrine46 25 1210.6DRD5, SLC6A2, MAOB, MAOA
49dopamine46 30 25 1211.3HTR1B, MAOA, SLC6A2, DRD5, MAOB
505-hydroxytryptamine468.2HTR1B, MAOB, TDO2, SLC6A2, MAOA

GO Terms for genes affiliated with Substance Abuse

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Sources:
17Gene Ontology
See all sources

Biological processes related to Substance Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of serotonin secretionGO:0140639.3MAOB, HTR1B
2response to ethanolGO:0454719.2MAOB, HTR1B
3xenobiotic metabolic processGO:0068059.1ADH4, MAOA, MAOB
4response to cocaineGO:0422209.0DRD5, HTR1B
5synaptic transmissionGO:0072688.4SLC6A2, DRD5, MAOA, HTR1B
6small molecule metabolic processGO:0442818.2TDO2, MAOB, MAOA, ADH4

Molecular functions related to Substance Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary amine oxidase activityGO:0081319.6MAOB, MAOA

Products for genes affiliated with Substance Abuse

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Substance Abuse

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet