MCID: SBS003
MIFTS: 55

Substance Abuse malady

Summaries for Substance Abuse

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning.

MalaCards: Substance Abuse, also known as substance abuse problem, is related to alcohol abuse and personality disorder. An important gene associated with Substance Abuse is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are melatonin degradation II and phenylalanine utilization. The compounds d amphetamine and (+)-butaclamol have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and liver, and related mouse phenotypes are growth/size and behavior/neurological.

CDC:3 (Data are for the U.S.)

Wikipedia:63 Substance abuse, also known as drug abuse, is a patterned use of a substance (drug) in which the user... more...

Aliases & Classifications for Substance Abuse

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

substance abuse 8 10
substance abuse problem 60


External Ids:

Disease Ontology8 DOID:302
NCIt39 C16522
SNOMED-CT56 66214007, 26416006
ICD9CM27 305
MeSH34 D019966

Related Diseases for Substance Abuse

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Substance Abuse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol abuse31.2DRD2, DRD3, ABCB7
2personality disorder31.0HTR1B, DRD2, MAOA, DRD3, MAOB, DRD4
3antisocial personality disorder31.0DRD2, MAOA, HTR1B
4substance dependence30.9DRD5, DRD4, DRD3, DRD2, PDYN
5schizophrenia30.9DRD4, HTR1B, PDYN, DRD2, DRD3, DRD5
6conduct disorder30.7DRD5, MAOA, DRD4, DRD2
7bipolar disorder30.7DRD2, SLC6A2, MAOB, PDYN, MAOA, DRD5
8anxiety disorder30.5DRD2, SLC6A2, MAOA, MAOB
9cocaine abuse30.4DRD2, MOBP
10mood disorder30.4MAOA, DRD4, DRD3, HTR1B, MAOB, SLC6A2
11pathological gambling30.4DRD4, DRD3, DRD2
12alcohol dependence30.4ADH4, MAOA, DRD4, DRD2, HTR1B, GGT2
13dementia30.3MAOA, MAOB
14attention deficit hyperactivity disorder30.2HTR1B, DRD2, SLC6A2, MAOB, MAOA, DRD4
15obesity30.2MAOB, DRD4, DRD2, SLC6A2, ABCB7, MAOA
16generalized anxiety disorder30.2MAOA, SLC6A2
17nicotine dependence30.0DRD2, DRD4
18panic disorder30.0DRD4, MAOA, SLC6A2
19anorexia nervosa30.0DRD4, MAOA, SLC6A2
20schizoaffective disorder30.0DRD3, DRD2, DRD4
21parkinson's disease30.0PDYN, MAOB, DRD3, DRD2, MAOA
22drug dependence30.0OPRL1, PDYN, DRD2, DRD3, MAOA
23opioid abuse10.5
24hepatitis10.5
25hepatitis c10.4
26cannabis abuse10.3
27major depressive disorder10.3
28borderline personality disorder10.3
29hepatitis a10.3
30fetal alcohol syndrome10.2
31eating disorder10.2
32developmental disabilities10.2
33barbiturate abuse10.0
34avoidant personality disorder10.0
35hallucinogen abuse10.0
36cerebritis10.0
37gastroschisis10.0
38somatization disorder10.0
39dependent personality disorder10.0
40multiple personality disorder10.0
41phencyclidine abuse10.0
42frontotemporal dementia10.0
43amphetamine abuse10.0
44antidepressant type abuse10.0
45polyhydramnios10.0
46hepatitis b10.0
47post-traumatic stress disorder10.0
48hepatitis d10.0
49hypercalcemia10.0
50alcohol-related neurodevelopmental disorder10.0

Graphical network of the top 20 diseases related to Substance Abuse:



Diseases related to substance abuse

Clinical Features for Substance Abuse

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Drugs & Therapeutics for Substance Abuse

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Substance Abuse

Drug clinical trials:

Search ClinicalTrials for Substance Abuse

Search NIH Clinical Center for Substance Abuse

Search CenterWatch for Substance Abuse

Genetic Tests for Substance Abuse

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Anatomical Context for Substance Abuse

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32MalaCards
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MalaCards organs/tissues related to Substance Abuse:

32
Testes, Brain, Liver, Cortex, Heart, Kidney, Hypothalamus, Pituitary, Subthalamic nucleus

Animal Models for Substance Abuse or affiliated genes

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Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Substance Abuse:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053789.8HTR1B, DRD2, DRD3, MAMSTR, ABCB7, SLC32A1
2MP:00053869.6DRD3, DRD2, HTR1B, PDYN, MOBP, DRD4
3MP:00036319.5TDO2, MOBP, PDYN, DRD2, DRD3, DRD4
4MP:00053769.4PDYN, DRD2, DRD3, DRD4, OPRL1, MAOA

Publications for Substance Abuse

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50PubMed
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Articles related to Substance Abuse:

(show top 50)    (show all 592)
idTitleAuthorsYear
1
Predictors of substance abuse treatment participation among homeless adults. (24238716)
2014
2
Science-based and practice-based innovativeness and performance of substance abuse treatment facilities. (23358133)
2014
3
Substance abuse journal: new beginnings. (24159902)
2013
4
Gene-environment correlation in the development of adolescent substance abuse: selection effects of child personality and mediation via contextual risk factors. (23398757)
2013
5
Multiple behavior interventions to prevent substance abuse and increase energy balance behaviors in middle school students. (23585821)
2013
6
Prediction and Prevention of Prescription Drug Abuse: Role of Preclinical Assessment of Substance Abuse Liability. (24008590)
2013
7
The Psychometric Properties of the Simple Screening Instrument for Substance Abuse. (23754847)
2013
8
Integrating issues of substance abuse and addiction into the predoctoral dental curriculum. (24002847)
2013
9
Which factors influence psychiatric diagnosing in substance abuse treatment? (23742628)
2013
10
From obesity to substance abuse: therapeutic opportunities for 5-HT2C receptor agonists. (24041919)
2013
11
Movement disorders in patients with schizophrenia and a history of substance abuse. (23532750)
2013
12
Genes, environments, and developmental research: methods for a multi-site study of early substance abuse. (23461817)
2013
13
Twenty-five years of volatile substance abuse mortality: a national mortality surveillance programme. (22882771)
2013
14
Substance Abuse Treatment in Persons with HIV/AIDS: Challenges in Managing Triple Diagnosis. (24274175)
2013
15
A qualitative analysis of women's experiences in single-gender versus mixed-gender substance abuse group therapy. (23607675)
2013
16
Substance abuse among migrant workers of Thai-Laos border, Thailand. (23140041)
2012
17
Substance abuse may be a risk factor for earlier onset of Huntington disease. (22274789)
2012
18
The date-delay framing effect in temporal discounting depends on substance abuse. (22709578)
2012
19
The role of culture in substance abuse treatment programs for American Indian and Alaska Native communities. (22588198)
2012
20
Delay discounting predicts adolescent substance abuse treatment outcome. (22182419)
2012
21
Fathers entering substance abuse treatment: An examination of substance abuse, trauma symptoms and parenting behaviors. (22305235)
2012
22
Management systems, patient quality improvement, resource availability, and substance abuse treatment quality. (22098342)
2012
23
Effects of cognitive impairment on substance abuse treatment attendance: predictive validation of a brief cognitive screening measure. (22443860)
2012
24
Negative urgency, distress tolerance, and substance abuse among college students. (22698894)
2012
25
Substance abuse and criminal thinking: testing the countervailing, mediation, and specificity hypotheses. (22251242)
2012
26
Thomas J. Stopka on Julia Dickson-GA^mez's on Substance abuse disorders treatment in El Salvador: analysis of policy-making-related failure. (23186472)
2012
27
Substance Abuse Treatment Stage and Personal Networks of Women in Substance Abuse Treatment. (22639705)
2012
28
Headache after substance abuse: a diagnostic dilemma. (22245279)
2012
29
"I didn't see this coming.": why are postbariatric patients in substance abuse treatment? Patients' perceptions of etiology and future recommendations. (22661046)
2012
30
The Brief Treatment Cost Analysis Tool (TCAT-Lite) for Substance Abuse Treatment: Reliability and Application. (23284225)
2012
31
Monitoring of substance abuse in India--initiatives & experiences. (22825598)
2012
32
HIV and substance abuse. (22762418)
2012
33
Substance abuse among individuals with intellectual disabilities. (22502840)
2012
34
Contingency management in community programs treating adolescent substance abuse: a feasibility study. (22299805)
2012
35
Co-morbid PTSD and suicidality in individuals with schizophrenia and substance and alcohol abuse. (20711764)
2011
36
Commentary on Genberg et al. (2011): the structural vulnerability imposed by hypersegregated US inner-city neighborhoods--a theoretical and practical challenge for substance abuse research. (21978310)
2011
37
Multi-organ dysfunction in bodybuilding possibly caused by prolonged hypercalcemia due to multi-substance abuse: case report and review of literature. (21072745)
2011
38
Introduction to Special Section on HIV/AIDS and Substance Use in the Caribbean (Part 3): Perspectives on Substance Abuse Treatment as HIV Prevention and Implementation Science in the Youth Culture of Web 2.0. (22158339)
2011
39
Lifetime substance abuse, family history of alcohol abuse/dependence and novelty seeking in eating disorders: comparison study of eating disorder subgroups. (19154214)
2009
40
Acute toxic polyradiculopathy after exorbitant intracarotid substance abuse. (16619129)
2006
41
Antisocial personality disorder in Turkish substance dependent patients and its relationship with anxiety, depression and a history of childhood abuse. (16910384)
2006
42
A form of DISC1 enriched in nucleus: altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse. (15657124)
2005
43
Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease. (15666411)
2005
44
Substance abuse and polyhydramnios. (12237634)
2002
45
Diagnosing antisocial personality disorder among substance abusers: the scid versus the MCMI-II. (11727884)
2001
46
Divalproex sodium in substance abusers with mood disorder. (11206596)
2000
47
Brief coping skills treatment for cocaine abuse: substance use outcomes at three months. (9581004)
1997
48
Pharmacotherapy of schizophrenia patients with comorbid substance abuse. (9165632)
1997
49
Clinical study of the relation of borderline personality disorder to Briquet's syndrome (hysteria), somatization disorder, antisocial personality disorder, and substance abuse disorders. (8942457)
1996
50
Exon and intron variants in the human tryptophan 2,3-dioxygenase gene: potential association with Tourette syndrome, substance abuse and other disorders. (8873217)
1996

Genetic Variations for Substance Abuse

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Expression for genes affiliated with Substance Abuse

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Substance Abuse

Search GEO for disease gene expression data for Substance Abuse.

Pathways for genes affiliated with Substance Abuse

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Sources:
37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 29KEGG, 49PharmGKB, 51QIAGEN
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Pathways related to Substance Abuse according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.4MAOB, MAOA
2
Hide members
10.4MAOB, MAOA
3
Tyrosine metabolism p.1 (dopamine)
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10.4MAOB, MAOA
4
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10.3TDO2, MAOB, MAOA
5
Hide members
10.3MAOA, MAOB, TDO2
6
Hide members
10.3ADH4, MAOB, MAOA
7
Hide members
10.3DRD4, DRD3, DRD2
8
Hide members
10.2MAOB, MAOA, DRD2, PDYN
910.2PDYN, DRD2, MAOA, MAOB
1010.2DRD2, DRD3, DRD4, DRD5
11
Hide members
10.2DRD2, DRD3, DRD4, DRD5
1210.2DRD2, DRD3, DRD4, DRD5
13
Hide members
10.2ADH4, GGT2, MAOB, MAOA
14
Hide members
10.1MAOA, DRD5, DRD4, DRD3, DRD2, HTR1B
15
Hide members
10.0PDYN, HTR1B, DRD2, DRD3, DRD4, DRD5
16
Hide members
10.0HTR1B, DRD2, DRD3, DRD4, DRD5, MAOA

Compounds for genes affiliated with Substance Abuse

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 2BitterDB, 49PharmGKB, 24HMDB
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Compounds related to Substance Abuse according to GeneCards/GeneDecks:

(show top 50)    (show all 192)
idCompoundScoreTop Affiliating Genes
1d amphetamine4410.6MAOB, DRD2, MAOA, SLC6A2
2(+)-butaclamol28 4411.6DRD4, DRD2, DRD5, DRD3
3piribedil28 4411.6DRD3, DRD2, DRD4, MAOB
4rotigotine44 28 1112.6DRD4, DRD3, DRD5, DRD2, MAOB
5benzamide44 211.6DRD3, DRD4, MAOA, DRD2
6methylphenidate44 49 1112.6MAOB, MAOA, DRD5, DRD4, SLC6A2, DRD2
7lisuride28 44 1112.6DRD4, HTR1B, DRD2, DRD3, DRD5
8pergolide28 44 1112.6DRD5, HTR1B, DRD2, DRD3, DRD4
9pramipexole44 49 28 1113.6HTR1B, DRD3, DRD5, DRD2, DRD4
10maoa4410.6SLC6A2, MAOB, DRD4, DRD2, HTR1B, MAOA
11cabergoline28 44 1112.6DRD5, HTR1B, DRD2, DRD4, DRD3
12roxindole28 4411.6DRD4, DRD3, DRD2, HTR1B
13paroxetine44 49 28 1113.6SLC6A2, MAOA, DRD4, DRD3, HTR1B
14aripiprazole28 49 44 11 2414.5DRD3, DRD4, DRD5, DRD2, HTR1B
15ropinirole44 1111.5DRD5, DRD3, MAOB, HTR1B, DRD2, DRD4
16ziprasidone49 28 44 1113.5DRD2, DRD4, DRD3, DRD5, HTR1B
17terguride28 4411.5DRD4, HTR1B, DRD2, DRD3
18piperazine44 1111.5DRD2, DRD3, DRD4, SLC6A2
19apomorphine44 28 1112.5DRD2, DRD4, HTR1B, MAOB, DRD5, DRD3
20amphetamine44 1111.5DRD4, DRD2, PDYN, MAOB, SLC6A2, MAOA
21m-tyramine4410.5SLC6A2, MAOB, MAOA
22spiperone28 4411.5DRD3, DRD2, DRD5, DRD4
23mhpg4410.5DRD4, MAOB, MAOA, SLC6A2
24quetiapine44 49 28 11 2414.5DRD5, HTR1B, DRD3, DRD4, DRD2
25fluoxetine49 44 28 1113.5MAOB, HTR1B, SLC6A2, MAOA, DRD2
26bromocriptine28 44 1112.5HTR1B, DRD2, DRD3, DRD4, DRD5
27methamphetamine44 49 1112.5DRD4, MAOB, SLC6A2, PDYN, MAOA, DRD3
28haloperidol44 28 2 49 1114.5MAOB, SLC6A2, DRD4, DRD3, DRD2, DRD5
296-hydroxydopamine4410.5MAOB, MAOA, DRD4, DRD2, PDYN, DRD3
30chlorpromazine44 28 49 1113.5ABCB7, DRD5, DRD4, DRD3, DRD2
31mptp4410.5DRD2, MAOB, SLC6A2, MAOA, DRD3
32catecholamine4410.5PDYN, DRD3, DRD4, DRD5, MAOA, MAOB
33(-)-sulpiride2810.5DRD4, DRD3, DRD2
34sulpiride44 28 1112.4DRD4, DRD3, DRD2, PDYN
35nicotine44 49 28 1113.4MAOA, DRD3, PDYN, DRD4, SLC6A2, DRD2
36(+)-sulpiride2810.4DRD4, DRD3, DRD2
37levodopa44 1111.4MAOB, DRD5, PDYN, HTR1B, DRD2, DRD3
385-hydroxytryptamine4410.4HTR1B, DRD2, DRD4, OPRL1, MAOA, MAOB
39olanzapine49 44 28 11 2414.4DRD2, DRD4, DRD3, HTR1B, DRD5
40talipexole4410.4DRD3, MAOB, DRD2
41gaba4410.4DRD4, SLC32A1, MAOB, SLC6A2, MAOA, DRD2
42cocaine44 1111.4PDYN, HTR1B, DRD2, DRD3, MOBP, MAOB
43norepinephrine44 11 2412.3MAOA, SLC6A2, MAOB, PDYN, DRD2, DRD3
44cis flupentixol2810.3DRD5, DRD3, DRD2
45Methotrimeprazine1110.3DRD2, DRD5, DRD4, DRD3
46dopamine44 28 11 2413.3SLC6A2, PDYN, DRD5, MAOA, MAOB, SLC32A1
47quinpirole44 2811.2DRD4, DRD3, DRD2, PDYN
48asenapine28 1111.1HTR1B, DRD2, DRD3, DRD4
49glutamate4410.1MAOA, SLC32A1, SLC6A2, ABCB7, MAOB, PDYN
50eticlopride28 4411.0DRD3, DRD4, DRD2

GO Terms for genes affiliated with Substance Abuse

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16Gene Ontology
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Cellular components related to Substance Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.8HTR1B, DRD2, DRD3, DRD4, DRD5, OPRL1
2integral to plasma membraneGO:0058879.7SLC6A2, HTR1B, DRD2, DRD3, DRD4, DRD5

Biological processes related to Substance Abuse according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1response to histamineGO:03477610.7DRD2, DRD3, DRD4
2negative regulation of voltage-gated calcium channel activityGO:190138610.7DRD2, DRD4
3adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.7DRD2, DRD3, DRD4
4regulation of dopamine secretionGO:01405910.7HTR1B, DRD2, DRD3
5negative regulation of dopamine receptor signaling pathwayGO:06016010.7DRD2, DRD3
6dopamine metabolic processGO:04241710.7DRD2, DRD3, DRD4
7negative regulation of protein secretionGO:05070910.6DRD2, DRD3, DRD4
8negative regulation of serotonin secretionGO:01406310.6HTR1B, MAOB
9positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.6DRD2, DRD4
10G-protein coupled receptor internalizationGO:00203110.6HTR1B, DRD2, DRD3
11behavioral response to cocaineGO:04814810.6DRD2, DRD3, DRD4
12arachidonic acid secretionGO:05048210.6DRD2, DRD3, DRD4
13response to cocaineGO:04222010.6DRD5, DRD3, DRD2, HTR1B
14synaptic transmission, dopaminergicGO:00196310.6DRD5, DRD4, DRD3, DRD2
15negative regulation of blood pressureGO:04577610.6DRD2, DRD3, DRD5
16regulation of dopamine uptake involved in synaptic transmissionGO:05158410.6DRD3, DRD2
17negative regulation of adenylate cyclase activityGO:00719410.6DRD4, DRD3, DRD2
18response to amphetamineGO:00197510.6DRD5, DRD4, DRD3, DRD2
19regulation of cAMP metabolic processGO:03081410.6DRD2, DRD3
20behavioral response to ethanolGO:04814910.6DRD4, DRD2
21phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.6DRD5, DRD2
22cellular calcium ion homeostasisGO:00687410.6DRD2, DRD3, DRD4, DRD5
23negative regulation of synaptic transmission, glutamatergicGO:05196710.6HTR1B, DRD2
24xenobiotic metabolic processGO:00680510.5MAOA, MAOB, GGT2, ADH4
25negative regulation of cAMP biosynthetic processGO:03081810.5HTR1B, DRD4
26response to ethanolGO:04547110.5MAOB, DRD3, HTR1B
27adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.5DRD3, DRD5
28synaptic transmissionGO:00726810.4PDYN, HTR1B, DRD5, MAOA, SLC32A1, SLC6A2
29prepulse inhibitionGO:06013410.4DRD3, DRD2
30associative learningGO:00830610.4DRD5, DRD2
31positive regulation of renal sodium excretionGO:03581510.3DRD2, DRD3
32circadian regulation of gene expressionGO:03292210.2DRD2, DRD3
33positive regulation of neuroblast proliferationGO:00205210.0OTP, DRD2

Molecular functions related to Substance Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary amine oxidase activityGO:00813110.4MAOB, MAOA
2dopamine bindingGO:03524010.3DRD5, DRD4, DRD3, DRD2
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.3DRD4, DRD3, DRD2
4drug bindingGO:00814410.1HTR1B, DRD2, DRD3, DRD4
5dopamine neurotransmitter receptor activityGO:00495210.0DRD5, DRD4

Products for genes affiliated with Substance Abuse

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  • Antibodies
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Sources for Substance Abuse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet