MCID: SBS003
MIFTS: 55

Substance Abuse malady

Summaries for Substance Abuse

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning.

MalaCards: Substance Abuse, also known as substance abuse problem, is related to alcohol abuse and personality disorder. An important gene associated with Substance Abuse is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are melatonin degradation II and phenylalanine utilization. The compounds d amphetamine and (+)-butaclamol have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and liver, and related mouse phenotypes are growth/size and behavior/neurological.

CDC:3 (Data are for the U.S.)

Wikipedia:63 Substance abuse, also known as drug abuse, is a patterned use of a substance (drug) in which the user... more...

Aliases & Classifications for Substance Abuse

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

substance abuse 8 10
substance abuse problem 60


External Ids:

Disease Ontology8 DOID:302
NCIt39 C16522
SNOMED-CT56 66214007, 26416006
ICD9CM27 305
MeSH34 D019966

Related Diseases for Substance Abuse

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Substance Abuse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol abuse31.2DRD2, DRD3, ABCB7
2personality disorder31.0HTR1B, DRD2, MAOA, DRD3, MAOB, DRD4
3antisocial personality disorder31.0DRD2, MAOA, HTR1B
4substance dependence30.9DRD5, DRD4, DRD3, DRD2, PDYN
5schizophrenia30.9DRD4, HTR1B, PDYN, DRD2, DRD3, DRD5
6conduct disorder30.7DRD5, MAOA, DRD4, DRD2
7bipolar disorder30.7DRD2, SLC6A2, MAOB, PDYN, MAOA, DRD5
8anxiety disorder30.5DRD2, SLC6A2, MAOA, MAOB
9cocaine abuse30.4DRD2, MOBP
10mood disorder30.4MAOA, DRD4, DRD3, HTR1B, MAOB, SLC6A2
11pathological gambling30.4DRD4, DRD3, DRD2
12alcohol dependence30.4ADH4, MAOA, DRD4, DRD2, HTR1B, GGT2
13dementia30.3MAOA, MAOB
14attention deficit hyperactivity disorder30.2HTR1B, DRD2, SLC6A2, MAOB, MAOA, DRD4
15obesity30.2MAOB, DRD4, DRD2, SLC6A2, ABCB7, MAOA
16generalized anxiety disorder30.2MAOA, SLC6A2
17nicotine dependence30.0DRD2, DRD4
18panic disorder30.0DRD4, MAOA, SLC6A2
19anorexia nervosa30.0DRD4, MAOA, SLC6A2
20schizoaffective disorder30.0DRD3, DRD2, DRD4
21parkinson's disease30.0PDYN, MAOB, DRD3, DRD2, MAOA
22drug dependence30.0OPRL1, PDYN, DRD2, DRD3, MAOA
23opioid abuse10.5
24hepatitis10.5
25hepatitis c10.4
26cannabis abuse10.3
27major depressive disorder10.3
28borderline personality disorder10.3
29hepatitis a10.3
30fetal alcohol syndrome10.2
31eating disorder10.2
32developmental disabilities10.2
33barbiturate abuse10.0
34avoidant personality disorder10.0
35hallucinogen abuse10.0
36cerebritis10.0
37gastroschisis10.0
38somatization disorder10.0
39dependent personality disorder10.0
40multiple personality disorder10.0
41phencyclidine abuse10.0
42frontotemporal dementia10.0
43amphetamine abuse10.0
44antidepressant type abuse10.0
45polyhydramnios10.0
46hepatitis b10.0
47post-traumatic stress disorder10.0
48hepatitis d10.0
49hypercalcemia10.0
50alcohol-related neurodevelopmental disorder10.0

Graphical network of the top 20 diseases related to Substance Abuse:



Diseases related to substance abuse

Clinical Features for Substance Abuse

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Drugs & Therapeutics for Substance Abuse

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Substance Abuse

Drug clinical trials:

Search ClinicalTrials for Substance Abuse

Search NIH Clinical Center for Substance Abuse

Search CenterWatch for Substance Abuse

Genetic Tests for Substance Abuse

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Anatomical Context for Substance Abuse

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32MalaCards
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MalaCards organs/tissues related to Substance Abuse:

32
Testes, Brain, Liver, Kidney, Heart, Pituitary, Hypothalamus, Cortex, Subthalamic nucleus

Animal Models for Substance Abuse or affiliated genes

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Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Substance Abuse:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053789.8HTR1B, DRD2, DRD3, MAMSTR, ABCB7, SLC32A1
2MP:00053869.6DRD3, DRD2, HTR1B, PDYN, MOBP, DRD4
3MP:00036319.5TDO2, MOBP, PDYN, DRD2, DRD3, DRD4
4MP:00053769.4PDYN, DRD2, DRD3, DRD4, OPRL1, MAOA

Publications for Substance Abuse

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50PubMed
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Articles related to Substance Abuse:

(show top 50)    (show all 592)
idTitleAuthorsYear
1
Criminal justice outcomes after engagement in outpatient substance abuse treatment. (24238717)
2014
2
Predictors and moderators of outcomes of HIV/STD sex risk reduction interventions in substance abuse treatment programs: a pooled analysis of two randomized controlled trials. (24433412)
2014
3
Sex-specific substance abuse treatment for female healthcare professionals: implications. (24389784)
2014
4
Substance use among women receiving post-rape medical care, associated post-assault concerns and current substance abuse: results from a national telephone household probability sample. (23380490)
2013
5
Employment status of veterans receiving substance abuse treatment from the U.S. Department of Veterans Affairs. (23370624)
2013
6
Substance abuse and smoking among a Canadian cohort of first episode psychosis patients. (23775243)
2013
7
Civil commitment for substance abuse. (24152775)
2013
8
Neuroeconomics and adolescent substance abuse: individual differences in neural networks and delay discounting. (23800488)
2013
9
Associations between public health indicators and injecting prescription opioids by prescription opioid abusers in substance abuse treatment. (23709299)
2013
10
Relationship of spirituality or religion to recovery from substance abuse: a systematic review. (24335768)
2013
11
Can MDMA play a role in the treatment of substance abuse? (23627786)
2013
12
Long-acting Preparations in Substance Abuse Management: A Review and Update. (23833336)
2013
13
Enhancing access and retention in substance abuse treatment: the role of Medicaid payment acceptance and cultural competence. (23669458)
2013
14
Breastfeeding and substance abuse. (23337847)
2013
15
Perceptions about recovery needs and drug-avoidance recovery behaviors among youth in substance abuse treatment. (24377168)
2013
16
Longitudinal Development of Mother-Infant Interaction During the First Year of Life Among Mothers with Substance Abuse and Psychiatric Problems and Their Infants. (24158304)
2013
17
Causes, consequences, and prevention of burnout among substance abuse treatment counselors: a rural versus urban comparison. (23662328)
2013
18
Substance abuse and the radiologic technologist. (24029884)
2013
19
Self-Stigma in Substance Abuse: Development of a New Measure. (23772099)
2013
20
A Study of Multiple Behavioral Addictions in a Substance Abuse Sample. (24304172)
2013
21
Chronic illness histories of adults entering treatment for co-occurring substance abuse and other mental health disorders. (22211340)
2012
22
Family treatment for bipolar disorder and substance abuse in late adolescence. (22504610)
2012
23
Study protocol: a randomized controlled trial of a computer-based depression and substance abuse intervention for people attending residential substance abuse treatment. (22325594)
2012
24
Real men are safe-culturally adapted: utilizing the Delphi process to revise real men are safe for an ethnically diverse group of men in substance abuse treatment. (22468973)
2012
25
Acute delirium and poor compliance in total hip arthroplasty patients with substance abuse disorders. (22325962)
2012
26
Do cultural and linguistic competence matter in Latinos' completion of mandated substance abuse treatment? (22898100)
2012
27
Training substance abuse clinicians in motivational interviewing using live supervision via teleconferencing. (22506795)
2012
28
A gender-specific approach to improving substance abuse treatment for women: The Healthy Steps to Freedom program. (22154034)
2012
29
Is parental socio-economic status related to the initiation of substance abuse by young people in an English city? An event history analysis. (22361091)
2012
30
Substance abuse prevention and treatment within the criminal justice system: an overview of the issues. (22468655)
2012
31
Culture, psychosomatics and substance abuse: the example of body image drugs. (22261875)
2012
32
Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse. (22933845)
2012
33
All might have won, but not all have the prize: optimal treatment for substance abuse among adolescents with conduct problems. (23170066)
2012
34
Aripiprazole, alcohol and substance abuse: a review. (23104650)
2012
35
Unmet mental health and substance abuse treatment needs of sexual minority elders. (22587357)
2012
36
Diana Rossi on Julia Dickson-GA^mez's "Substance abuse disorders treatment in El Salvador: analysis of policy-making-related failure". (23186471)
2012
37
Measurement of gender-sensitive treatment for women in mixed-gender substance abuse treatment programs. (22138537)
2012
38
Hope and recovery from substance abuse for female drug offenders in Taiwan. (22186881)
2012
39
'Poppers maculopathy'--an emerging ophthalmic reaction to recreational substance abuse. (22402700)
2012
40
The relationship between substance abuse treatment completion, sociodemographics, substance use characteristics, and criminal history. (22489580)
2012
41
Making the public mental health, developmental disabilities, and substance abuse system more accessible: an invitation to recovery. (19534056)
2009
42
Subtypes of substance dependence and abuse: implications for diagnostic classification and empirical research. (16930166)
2006
43
A mechanism for gamma-hydroxybutyrate (GHB) as a drug and a substance of abuse]. (15745703)
2005
44
The stability and impact of environmental factors on substance use and problems after adolescent outpatient treatment for cannabis abuse or dependence. (15783279)
2005
45
Gender differences and conduct disorder among American Indian adolescents in substance abuse treatment. (12733762)
2003
46
Targeting nicotine addiction in a substance abuse program. (18552720)
2003
47
Long forms of the dopamine receptor (DRD4) gene VNTR are more prevalent in substance abusers: no interaction with functional alleles of the catechol-o-methyltransferase (COMT) gene. (11054777)
2000
48
Prevalence of attention-deficit/hyperactivity disorder and conduct disorder among substance abusers. (10830144)
2000
49
Substance abuse vulnerability and D2 receptor genes. (7681236)
1993
50
The antisocial personality disorder diagnosis in substance abusers: problems and issues. (1869868)
1991

Genetic Variations for Substance Abuse

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Expression for genes affiliated with Substance Abuse

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Substance Abuse

Search GEO for disease gene expression data for Substance Abuse.

Pathways for genes affiliated with Substance Abuse

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Sources:
37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 29KEGG, 49PharmGKB, 51QIAGEN
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Pathways related to Substance Abuse according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4MAOB, MAOA
2
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10.4MAOB, MAOA
3
Tyrosine metabolism p.1 (dopamine)
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10.4MAOB, MAOA
4
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10.3TDO2, MAOB, MAOA
5
Hide members
10.3MAOA, MAOB, TDO2
6
Hide members
10.3ADH4, MAOB, MAOA
7
Hide members
10.3DRD4, DRD3, DRD2
8
Hide members
10.2MAOB, MAOA, DRD2, PDYN
910.2PDYN, DRD2, MAOA, MAOB
1010.2DRD2, DRD3, DRD4, DRD5
11
Hide members
10.2DRD2, DRD3, DRD4, DRD5
1210.2DRD2, DRD3, DRD4, DRD5
13
Hide members
10.2ADH4, GGT2, MAOB, MAOA
14
Hide members
10.1MAOA, DRD5, DRD4, DRD3, DRD2, HTR1B
15
Hide members
10.0PDYN, HTR1B, DRD2, DRD3, DRD4, DRD5
16
Hide members
10.0HTR1B, DRD2, DRD3, DRD4, DRD5, MAOA

Compounds for genes affiliated with Substance Abuse

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 2BitterDB, 49PharmGKB, 24HMDB
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Compounds related to Substance Abuse according to GeneCards/GeneDecks:

(show top 50)    (show all 192)
idCompoundScoreTop Affiliating Genes
1d amphetamine4410.6MAOB, DRD2, MAOA, SLC6A2
2(+)-butaclamol28 4411.6DRD4, DRD2, DRD5, DRD3
3piribedil28 4411.6DRD3, DRD2, DRD4, MAOB
4rotigotine44 28 1112.6DRD4, DRD3, DRD5, DRD2, MAOB
5benzamide44 211.6DRD3, DRD4, MAOA, DRD2
6methylphenidate44 49 1112.6MAOB, MAOA, DRD5, DRD4, SLC6A2, DRD2
7lisuride28 44 1112.6DRD4, HTR1B, DRD2, DRD3, DRD5
8pergolide28 44 1112.6DRD5, HTR1B, DRD2, DRD3, DRD4
9pramipexole44 49 28 1113.6HTR1B, DRD3, DRD5, DRD2, DRD4
10maoa4410.6SLC6A2, MAOB, DRD4, DRD2, HTR1B, MAOA
11cabergoline28 44 1112.6DRD5, HTR1B, DRD2, DRD4, DRD3
12roxindole28 4411.6DRD4, DRD3, DRD2, HTR1B
13paroxetine44 49 28 1113.6SLC6A2, MAOA, DRD4, DRD3, HTR1B
14aripiprazole28 49 44 11 2414.5DRD3, DRD4, DRD5, DRD2, HTR1B
15ropinirole44 1111.5DRD5, DRD3, MAOB, HTR1B, DRD2, DRD4
16ziprasidone49 28 44 1113.5DRD2, DRD4, DRD3, DRD5, HTR1B
17terguride28 4411.5DRD4, HTR1B, DRD2, DRD3
18piperazine44 1111.5DRD2, DRD3, DRD4, SLC6A2
19apomorphine44 28 1112.5DRD2, DRD4, HTR1B, MAOB, DRD5, DRD3
20amphetamine44 1111.5DRD4, DRD2, PDYN, MAOB, SLC6A2, MAOA
21m-tyramine4410.5SLC6A2, MAOB, MAOA
22spiperone28 4411.5DRD3, DRD2, DRD5, DRD4
23mhpg4410.5DRD4, MAOB, MAOA, SLC6A2
24quetiapine44 49 28 11 2414.5DRD5, HTR1B, DRD3, DRD4, DRD2
25fluoxetine49 44 28 1113.5MAOB, HTR1B, SLC6A2, MAOA, DRD2
26bromocriptine28 44 1112.5HTR1B, DRD2, DRD3, DRD4, DRD5
27methamphetamine44 49 1112.5DRD4, MAOB, SLC6A2, PDYN, MAOA, DRD3
28haloperidol44 28 2 49 1114.5MAOB, SLC6A2, DRD4, DRD3, DRD2, DRD5
296-hydroxydopamine4410.5MAOB, MAOA, DRD4, DRD2, PDYN, DRD3
30chlorpromazine44 28 49 1113.5ABCB7, DRD5, DRD4, DRD3, DRD2
31mptp4410.5DRD2, MAOB, SLC6A2, MAOA, DRD3
32catecholamine4410.5PDYN, DRD3, DRD4, DRD5, MAOA, MAOB
33(-)-sulpiride2810.5DRD4, DRD3, DRD2
34sulpiride44 28 1112.4DRD4, DRD3, DRD2, PDYN
35nicotine44 49 28 1113.4MAOA, DRD3, PDYN, DRD4, SLC6A2, DRD2
36(+)-sulpiride2810.4DRD4, DRD3, DRD2
37levodopa44 1111.4MAOB, DRD5, PDYN, HTR1B, DRD2, DRD3
385-hydroxytryptamine4410.4HTR1B, DRD2, DRD4, OPRL1, MAOA, MAOB
39olanzapine49 44 28 11 2414.4DRD2, DRD4, DRD3, HTR1B, DRD5
40talipexole4410.4DRD3, MAOB, DRD2
41gaba4410.4DRD4, SLC32A1, MAOB, SLC6A2, MAOA, DRD2
42cocaine44 1111.4PDYN, HTR1B, DRD2, DRD3, MOBP, MAOB
43norepinephrine44 11 2412.3MAOA, SLC6A2, MAOB, PDYN, DRD2, DRD3
44cis flupentixol2810.3DRD5, DRD3, DRD2
45Methotrimeprazine1110.3DRD2, DRD5, DRD4, DRD3
46dopamine44 28 11 2413.3SLC6A2, PDYN, DRD5, MAOA, MAOB, SLC32A1
47quinpirole44 2811.2DRD4, DRD3, DRD2, PDYN
48asenapine28 1111.1HTR1B, DRD2, DRD3, DRD4
49glutamate4410.1MAOA, SLC32A1, SLC6A2, ABCB7, MAOB, PDYN
50eticlopride28 4411.0DRD3, DRD4, DRD2

GO Terms for genes affiliated with Substance Abuse

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Sources:
16Gene Ontology
See all sources

Cellular components related to Substance Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.8HTR1B, DRD2, DRD3, DRD4, DRD5, OPRL1
2integral to plasma membraneGO:0058879.7SLC6A2, HTR1B, DRD2, DRD3, DRD4, DRD5

Biological processes related to Substance Abuse according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1response to histamineGO:03477610.7DRD2, DRD3, DRD4
2negative regulation of voltage-gated calcium channel activityGO:190138610.7DRD2, DRD4
3adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.7DRD2, DRD3, DRD4
4regulation of dopamine secretionGO:01405910.7HTR1B, DRD2, DRD3
5negative regulation of dopamine receptor signaling pathwayGO:06016010.7DRD2, DRD3
6dopamine metabolic processGO:04241710.7DRD2, DRD3, DRD4
7negative regulation of protein secretionGO:05070910.6DRD2, DRD3, DRD4
8negative regulation of serotonin secretionGO:01406310.6HTR1B, MAOB
9positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.6DRD2, DRD4
10G-protein coupled receptor internalizationGO:00203110.6HTR1B, DRD2, DRD3
11behavioral response to cocaineGO:04814810.6DRD2, DRD3, DRD4
12arachidonic acid secretionGO:05048210.6DRD2, DRD3, DRD4
13response to cocaineGO:04222010.6DRD5, DRD3, DRD2, HTR1B
14synaptic transmission, dopaminergicGO:00196310.6DRD5, DRD4, DRD3, DRD2
15negative regulation of blood pressureGO:04577610.6DRD2, DRD3, DRD5
16regulation of dopamine uptake involved in synaptic transmissionGO:05158410.6DRD3, DRD2
17negative regulation of adenylate cyclase activityGO:00719410.6DRD4, DRD3, DRD2
18response to amphetamineGO:00197510.6DRD5, DRD4, DRD3, DRD2
19regulation of cAMP metabolic processGO:03081410.6DRD2, DRD3
20behavioral response to ethanolGO:04814910.6DRD4, DRD2
21phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.6DRD5, DRD2
22cellular calcium ion homeostasisGO:00687410.6DRD2, DRD3, DRD4, DRD5
23negative regulation of synaptic transmission, glutamatergicGO:05196710.6HTR1B, DRD2
24xenobiotic metabolic processGO:00680510.5MAOA, MAOB, GGT2, ADH4
25negative regulation of cAMP biosynthetic processGO:03081810.5HTR1B, DRD4
26response to ethanolGO:04547110.5MAOB, DRD3, HTR1B
27adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.5DRD3, DRD5
28synaptic transmissionGO:00726810.4PDYN, HTR1B, DRD5, MAOA, SLC32A1, SLC6A2
29prepulse inhibitionGO:06013410.4DRD3, DRD2
30associative learningGO:00830610.4DRD5, DRD2
31positive regulation of renal sodium excretionGO:03581510.3DRD2, DRD3
32circadian regulation of gene expressionGO:03292210.2DRD2, DRD3
33positive regulation of neuroblast proliferationGO:00205210.0OTP, DRD2

Molecular functions related to Substance Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary amine oxidase activityGO:00813110.4MAOB, MAOA
2dopamine bindingGO:03524010.3DRD5, DRD4, DRD3, DRD2
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.3DRD4, DRD3, DRD2
4drug bindingGO:00814410.1HTR1B, DRD2, DRD3, DRD4
5dopamine neurotransmitter receptor activityGO:00495210.0DRD5, DRD4

Products for genes affiliated with Substance Abuse

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  • Antibodies
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Sources for Substance Abuse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet