MCID: SBS004
MIFTS: 48

Substance Dependence malady

Mental diseases category
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Summaries for Substance Dependence

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A substance-related disorder that involves the continued use of alcohol or other drugs despite despite problems related to use of the substance.

MalaCards: Substance Dependence is related to personality disorder and drug dependence. An important gene associated with Substance Dependence is DRD5 (dopamine receptor D5), and among its related pathways are GPCRs, Other and Hypothetical Network for Drug Addiction. The compounds cis flupentixol and (-)-sulpiride have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and eye, and related mouse phenotypes are taste/olfaction and adipose tissue.

Wikipedia:65 Substance dependence, commonly called drug addiction, is a compulsive need to use drugs in order to... more...

Aliases & Classifications for Substance Dependence

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

substance dependence 8 10 45 62


External Ids:

Disease Ontology8 DOID:9973
NCIt40 C35458

Related Diseases for Substance Dependence

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Substance Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder30.9DRD2, TPH1, DRD4, DRD3
2drug dependence30.6DRD2, CNR1, DRD3
3conduct disorder30.6DRD5, DRD2, DRD4
4bipolar disorder30.5CNR1, DRD4, DRD5, DRD3, TPH1, DRD2
5attention deficit hyperactivity disorder30.4DRD4, DRD2, DRD5
6alcohol dependence30.3CNR1, DRD2, DRD4
7nicotine dependence30.2DRD2, DRD4
8schizophrenia30.2CNR1, DRD5, DRD4, DRD3, DRD2, TPH1
9mood disorder30.1DRD3, TPH1, CNR1, DRD4, DRD2
10substance abuse30.0DRD3, DRD2, DRD4, CNR1
11cocaine dependence30.0DRD2, DRD3
12drug addiction30.0DRD2, DRD3
13panic disorder29.9TPH1, DRD4
14anxiety disorder29.9DRD2, TPH1, CNR1
15pathological gambling29.9DRD3, DRD4, DRD2
16alzheimer's disease29.7DRD2, DRD4, CNR1, DRD3, TPH1
17migraine29.7DRD2, DRD3, DRD5, DRD4, CNR1, TPH1
18antisocial personality disorder10.4
19borderline personality disorder10.4
20alexithymia10.4
21bulimia nervosa10.1
22eating disorder10.1
23chronic pain10.1
24oppositional defiant disorder10.1DRD4
25focal dystonia10.0DRD5, DRD2
26opiate dependence10.0DRD3, DRD2
27alcohol abuse10.0DRD2, DRD3
28movement disease10.0DRD2, DRD3
29delusional disorder10.0DRD4, DRD2
30seasonal affective disorder10.0DRD4, TPH1
31heroin dependence10.0DRD4, DRD2
32hyperprolactinemia10.0DRD4, DRD2
33hepatitis c10.0
34dependent personality disorder10.0
35hepatitis b10.0
36hepatitis10.0
37phobic disorder10.0
38sleep disorder10.0
39sickle cell disease10.0
40hiv-110.0
41parkinson's disease10.0DRD3, DRD2, CNR1
42gilles de la tourette syndrome10.0DRD5, DRD2, DRD4
43huntington's disease10.0CNR1, DRD2
44melanoma10.0DRD2, DRD3, TPH1
45schizoaffective disorder10.0DRD4, DRD3, DRD2
46anorexia nervosa9.9DRD4, TPH1, CNR1
47obsessive-compulsive disorder9.9DRD2, DRD4, TPH1, DRD3
48obesity9.9CNR1, DRD2, DRD4
49psychotic disorder9.8DRD4, DRD3, DRD2, CNR1, TPH1

Graphical network of the top 20 diseases related to Substance Dependence:



Diseases related to substance dependence

Symptoms for Substance Dependence

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Drugs & Therapeutics for Substance Dependence

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Substance Dependence

Search NIH Clinical Center for Substance Dependence

Genetic Tests for Substance Dependence

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Anatomical Context for Substance Dependence

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33MalaCards
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MalaCards organs/tissues related to Substance Dependence:

33
Testes, Brain, Eye

Animal Models for Substance Dependence or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Substance Dependence:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.3DRD2, CNR1
2MP:00053758.5DRD2, DRD3, CNR1, TPH1
3MP:00053858.3DRD2, DRD3, DRD5, TPH1
4MP:00053867.6TPH1, CNR1, DRD4, DRD3, DRD2
5MP:00036317.6CNR1, DRD4, DRD5, DRD3, DRD2
6MP:00053767.4TPH1, CNR1, DRD4, DRD3, DRD2

Publications for Substance Dependence

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Sources:
52PubMed
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Articles related to Substance Dependence:

(show top 50)    (show all 318)
idTitleAuthorsYear
1
TRICARE; removal of the prohibition to use addictive drugs in the maintenance treatment of substance dependence in TRICARE beneficiaries. Final rule. (24156132)
2013
2
Re-offending in forensic patients released from secure care: the role of antisocial/borderline personality disorder co-morbidity, substance dependence and severe childhood conduct disorder. (23371302)
2013
3
Effects of working memory load, a history of conduct disorder, and sex on decision making in substance dependent individuals. (24011986)
2013
4
Striatal dopamine release in schizophrenia comorbid with substance dependence. (22869037)
2013
5
Impact of Physical Health on Treatment for Co-occurring Depression and Substance Dependence. (24223036)
2013
6
Ibogaine in the treatment of substance dependence. (23627782)
2013
7
Poor sleep at baseline predicts worse mood outcomes in patients with co-occurring bipolar disorder and substance dependence. (22313797)
2012
8
Integrated exposure-based therapy for co-occurring posttraumatic stress disorder and substance dependence: a randomized controlled trial. (22893166)
2012
9
Developmental momentum toward substance dependence: natural histories and pliability of risk factors in youth experiencing chronic stress. (22257754)
2012
10
Predictors of retention in the 'voluntary' and 'quasi-compulsory' treatment of substance dependence in europe. (21228594)
2011
11
Non-suicidal self-injury by intravenous application of nicotine in a patient with borderline personality disorder resulting in substance dependence. (21306599)
2011
12
Genetic vulnerability and susceptibility to substance dependence. (21338875)
2011
13
Emotion regulation and substance use frequency in women with substance dependence and borderline personality disorder receiving dialectical behavior therapy. (21091162)
2011
14
Remission from substance dependence in U.S. Whites, African Americans, and Latinos. (21161807)
2010
15
Greater activation in left hemisphere language-related regions during simple judgment tasks among substance-dependent patients in treatment for alcoholism. (19951293)
2010
16
Time to Relapse Questionnaire (TRQ): a measure of sudden relapse in substance dependence. (20465371)
2010
17
Comparing outcomes of 'voluntary' and 'quasi-compulsory' treatment of substance dependence in Europe. (20016186)
2010
18
Mental disorders as risk factors for later substance dependence: estimates of optimal prevention and treatment benefits. (19046473)
2009
19
Substance dependence and remission in schizophrenia: A comparison of schizophrenia and affective disorders. (19375237)
2009
20
Treatment of Co-occurring Depression and Substance Dependence: Using Meta-analysis to Guide Clinical Recommendations. (19668349)
2008
21
Drug-dependent boys are more depressed compared to girls: a comorbidity study of substance dependence and mental disorders. (18552492)
2008
22
Potential genetic predictors for individual vulnerability to substance dependence]. (18411704)
2008
23
The relationship of cumulative and proximal adversity to onset of substance dependence symptoms in two American Indian communities. (17640829)
2007
24
Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence. (16741937)
2006
25
Multiple substance dependence and course of alcoholism among Alaska native men and women. (16603457)
2006
26
Antisocial personality disorder in Turkish substance dependent patients and its relationship with anxiety, depression and a history of childhood abuse. (16910384)
2006
27
Comments on "Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans". (15389767)
2005
28
Co-occurring substance dependence and depression: practical implications and next questions. (16367973)
2005
29
Review: antidepressants are moderately effective in people with depression and a substance dependence disorder. (15504796)
2004
30
From basic research to public health policy: WHO report on the neuroscience of substance dependence. (15345278)
2004
31
Mate similarity for substance dependence and antisocial personality disorder symptoms among parents of patients and controls. (15276222)
2004
32
Pain management and symptoms of substance dependence among patients with sickle cell disease. (12948577)
2003
33
High- and low-structure treatments for substance dependence: role of learned helplessness. (14510041)
2003
34
A comparison of personality characteristics of patients with posttraumatic stress disorders and substance dependence: preliminary findings. (14504572)
2003
35
Psychiatric and substance dependence comorbidities, sexually transmitted diseases, and risk behaviors among methamphetamine-dependent gay and bisexual men seeking outpatient drug abuse treatment. (12825759)
2003
36
Choice, rationality, and substance dependence. (12189083)
2002
37
Etiologic connections among substance dependence, antisocial behavior, and personality: modeling the externalizing spectrum. (12150417)
2002
38
Effects of major depression on remission and relapse of substance dependence. (11926938)
2002
39
Antisociality, substance dependence, and the DRD5 gene: a preliminary study. (11054773)
2000
40
Effects of substance dependence on outcomes of patients in a randomized trial of two case management models. (10783183)
2000
41
Substance dependence. A hospital based survey. (11533751)
2000
42
Clinical implications for four drugs of the DSM-IV distinction between substance dependence with and without a physiological component. (9892296)
1999
43
Genetic studies of alcoholism and substance dependence. (10441565)
1999
44
Effect of gender, treatment site and psychiatric comorbidity on quality of life outcome in substance dependence. (10189514)
1999
45
"Seeking safety": outcome of a new cognitive-behavioral psychotherapy for women with posttraumatic stress disorder and substance dependence. (9690186)
1998
46
Twin studies of adult psychiatric and substance dependence disorders: are they biased by differences in the environmental experiences of monozygotic and dizygotic twins in childhood and adolescence? (9626718)
1998
47
Quantitative electroencephalographic differences associated with alcohol, cocaine, heroin and dual-substance dependence. (9246556)
1997
48
D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects. (9345090)
1997
49
A preliminary investigation of alexithymia in men with psychoactive substance dependence. (2386256)
1990
50
Proposed changes in DSM-III substance dependence criteria. (3812810)
1987

Variations for Substance Dependence

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Expression for genes affiliated with Substance Dependence

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Substance Dependence

Search GEO for disease gene expression data for Substance Dependence.

Pathways for genes affiliated with Substance Dependence

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Sources:
50PathCards, 38NCBI BioSystems Database, 51PharmGKB, 30KEGG, 53QIAGEN, 55Reactome
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Pathways related to Substance Dependence according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1DRD3, DRD4
29.1DRD2, DRD4
3
Show member pathways
Nicotine Activity on Dopaminergic Neurons38
8.6DRD2, DRD3, DRD4
4
Show member pathways
8.2DRD4, DRD5, DRD3, DRD2
5
Show member pathways
8.2DRD4, DRD5, DRD3, DRD2
68.2DRD4, DRD5, DRD3, DRD2
7
Show member pathways
7.6DRD2, DRD3, DRD5, DRD4, CNR1
8
Show member pathways
7.6CNR1, DRD4, DRD5, DRD3, DRD2
9
Show member pathways
7.1DRD2, DRD3, DRD5, DRD4, CNR1, TPH1

Compounds for genes affiliated with Substance Dependence

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Sources:
29IUPHAR, 45Novoseek, 51PharmGKB, 11DrugBank, 3BitterDB, 24HMDB
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Compounds related to Substance Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1cis flupentixol299.4DRD2, DRD5, DRD3
2(-)-sulpiride299.0DRD4, DRD2, DRD3
3(+)-sulpiride299.0DRD2, DRD3, DRD4
4eticlopride45 2910.0DRD4, DRD3, DRD2
5fluphenazine29 45 51 1112.0DRD2, DRD5, DRD4
6nemonapride45 51 2911.0DRD4, DRD2, DRD3
7sch 23390459.0DRD3, DRD2, DRD4
8remoxipride45 119.9DRD2, DRD3, DRD4
9piribedil29 459.9DRD4, DRD2, DRD3
10benzamide3 459.9DRD3, DRD2, DRD4
11methylphenidate45 51 1110.9DRD4, DRD5, DRD2
12raclopride45 299.9DRD2, DRD3, DRD4
13roxindole29 459.9DRD2, DRD4, DRD3
14terguride45 299.9DRD2, DRD3, DRD4
15piperazine45 119.8DRD2, DRD3, DRD4
16sulpiride45 29 1110.8DRD2, DRD4, DRD3
17bupropion51 45 24 1111.8DRD3, CNR1, DRD2
18maoa458.8TPH1, DRD4, DRD2
19(+)-butaclamol45 299.6DRD4, DRD2, DRD3, DRD5
20rotigotine29 45 1110.6DRD2, DRD3, DRD4, DRD5
21spiperone45 299.6DRD2, DRD3, DRD5, DRD4
22ropinirole45 119.6DRD4, DRD5, DRD2, DRD3
23lisuride45 29 1110.6DRD3, DRD4, DRD2, DRD5
24pergolide45 29 1110.6DRD2, DRD4, DRD3, DRD5
25pramipexole45 29 51 1111.6DRD3, DRD4, DRD2, DRD5
26cabergoline45 29 1110.6DRD3, DRD5, DRD4, DRD2
27paliperidone45 119.6DRD3, DRD4, DRD2
28aripiprazole29 45 51 24 1112.6DRD2, DRD4, DRD3, DRD5
29ziprasidone29 51 45 1111.6DRD5, DRD3, DRD2, DRD4
30quetiapine45 51 29 24 1112.6DRD5, DRD4, DRD3, DRD2
31chlorpromazine29 45 51 1111.6DRD5, DRD4, DRD3, DRD2
32bromocriptine45 29 1110.6DRD4, DRD5, DRD3, DRD2
33catecholamine458.5DRD5, DRD4, DRD3, TPH1
34methamphetamine45 51 1110.5DRD3, TPH1, DRD4, DRD2
35iloperidone51 45 29 1111.5DRD2, DRD4, DRD3
36haloperidol45 51 29 3 1112.5DRD5, DRD3, DRD2, DRD4
37amphetamine45 51 1110.4DRD2, DRD4, CNR1, TPH1
38quinpirole45 299.4CNR1, DRD4, DRD3, DRD2
39heroin45 51 1110.4DRD4, CNR1, DRD2, DRD3
40asenapine29 119.3DRD4, DRD2, DRD3
41cocaine45 119.2CNR1, DRD4, DRD2, DRD3
425-hydroxytryptamine458.1DRD4, DRD2, TPH1, CNR1
43apomorphine29 45 1110.0DRD2, CNR1, DRD4, DRD5, DRD3
44olanzapine45 51 29 24 1112.0CNR1, DRD4, DRD5, DRD3, DRD2
45clozapine45 29 51 1111.0DRD2, DRD4, DRD5, DRD3, CNR1
46nicotine45 29 51 1110.9TPH1, CNR1, DRD4, DRD3, DRD2
47cyclic amp45 248.8DRD3, CNR1, DRD4, DRD5, TPH1
48levodopa45 118.6TPH1, CNR1, DRD4, DRD3, DRD2, DRD5
49norepinephrine45 24 119.6TPH1, CNR1, DRD4, DRD5, DRD3, DRD2
50dopamine45 29 24 1110.5DRD2, DRD3, DRD5, DRD4, CNR1, TPH1

GO Terms for genes affiliated with Substance Dependence

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16Gene Ontology
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Cellular components related to Substance Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicleGO:0301399.3DRD2, DRD3
2dendritic spineGO:0431979.1DRD2, DRD4
3integral component of plasma membraneGO:0058877.6DRD2, DRD3, DRD5, DRD4, CNR1
4plasma membraneGO:0058867.3CNR1, DRD4, DRD5, DRD3, DRD2

Biological processes related to Substance Dependence according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1phospholipase C-activating dopamine receptor signaling pathwayGO:0601589.9DRD5, DRD2
2adenylate cyclase-activating dopamine receptor signaling pathwayGO:0071919.8DRD5, DRD3
3regulation of locomotion involved in locomotory behaviorGO:0903259.8DRD2, DRD3
4negative regulation of dopamine receptor signaling pathwayGO:0601609.8DRD3, DRD2
5regulation of dopamine uptake involved in synaptic transmissionGO:0515849.8DRD3, DRD2
6associative learningGO:0083069.8DRD2, DRD5
7regulation of cAMP metabolic processGO:0308149.8DRD2, DRD3
8G-protein coupled receptor internalizationGO:0020319.7DRD2, DRD3
9prepulse inhibitionGO:0601349.7DRD2, DRD3
10negative regulation of dopamine secretionGO:0336029.7CNR1, DRD2
11positive regulation of renal sodium excretionGO:0358159.7DRD3, DRD2
12circadian regulation of gene expressionGO:0329229.6DRD2, DRD3
13regulation of synaptic transmission, GABAergicGO:0322289.6DRD2, CNR1
14negative regulation of protein kinase B signalingGO:0518989.6DRD3, DRD2
15positive regulation of cytokinesisGO:0324679.5DRD3, DRD2
16response to nicotineGO:0350949.5CNR1, DRD2
17positive regulation of dopamine uptake involved in synaptic transmissionGO:0515869.5DRD4, DRD2
18negative regulation of voltage-gated calcium channel activityGO:19013869.5DRD2, DRD4
19visual learningGO:0085429.4DRD2, DRD3
20behavioral response to ethanolGO:0481499.4DRD2, DRD4
21response to ethanolGO:0454719.3DRD3, CNR1
22social behaviorGO:0351769.2DRD3, DRD4
23response to morphineGO:0432789.2DRD2, DRD3, CNR1
24locomotory behaviorGO:0076269.1DRD2, DRD3
25circadian rhythmGO:0076239.1TPH1, DRD4
26response to histamineGO:0347769.0DRD2, DRD3, DRD4
27adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:0071959.0DRD4, DRD3, DRD2
28dopamine metabolic processGO:0424179.0DRD2, DRD3, DRD4
29negative regulation of protein secretionGO:0507099.0DRD4, DRD3, DRD2
30behavioral response to cocaineGO:0481489.0DRD2, DRD3, DRD4
31arachidonic acid secretionGO:0504829.0DRD4, DRD3, DRD2
32negative regulation of adenylate cyclase activityGO:0071949.0DRD4, DRD3, DRD2
33response to cocaineGO:0422208.8CNR1, DRD5, DRD3, DRD2
34negative regulation of blood pressureGO:0457768.8DRD2, DRD3, DRD5, CNR1
35synaptic transmission, dopaminergicGO:0019638.6DRD2, DRD3, DRD5, DRD4
36response to amphetamineGO:0019758.6DRD4, DRD5, DRD3, DRD2
37cellular calcium ion homeostasisGO:0068748.6DRD4, DRD5, DRD3, DRD2

Molecular functions related to Substance Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium channel regulator activityGO:0154599.1DRD2, DRD4
2dopamine neurotransmitter receptor activityGO:0049528.9DRD5, DRD4
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015918.6DRD2, DRD3, DRD4
4dopamine bindingGO:0352408.3DRD2, DRD3, DRD5, DRD4
5drug bindingGO:0081447.9CNR1, DRD4, DRD3, DRD2

Products for genes affiliated with Substance Dependence

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Substance Dependence

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet