MCID: SBS004
MIFTS: 54

Substance Dependence malady

Summaries for Substance Dependence

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A substance-related disorder that involves the continued use of alcohol or other drugs despite despite problems related to use of the substance.

MalaCards: Substance Dependence is related to personality disorder and drug dependence. An important gene associated with Substance Dependence is DRD5 (dopamine receptor D5), and among its related pathways are Presynaptic nicotinic acetylcholine receptors and Dopamine-DARPP32 Feedback onto cAMP Pathway. The compounds (+)-butaclamol and piperazine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and lung, and related mouse phenotypes are taste/olfaction and adipose tissue.

Wikipedia:63 Substance dependence, commonly called drug addiction, is a compulsive need to use drugs in order to... more...

Aliases & Classifications for Substance Dependence

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

substance dependence 8 10 44 60


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Disease Ontology8 DOID:9973
NCIt39 C35458

Related Diseases for Substance Dependence

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17GeneCards, 18GeneDecks
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Diseases related to Substance Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder30.9TPH1, SLC6A4, SLC6A3, DRD4, DRD3, DRD2
2drug dependence30.9SLC6A3, CNR1, OPRM1, OPRD1, OPRK1, DRD3
3alcohol dependence30.8ADH7, ADH4, ADH1A, SLC6A4, CNR1, CHRNA5
4bipolar disorder30.7TPH1, SLC6A4
5antisocial personality disorder30.6SLC6A4, SLC6A3, DRD2, HTR1B
6substance abuse30.6ADH4, SLC6A4, SLC6A3, CNR1, OPRM1, DRD4
7conduct disorder30.5DRD2, DRD4, DRD5, SLC6A3, SLC6A4
8borderline personality disorder30.5TPH1, SLC6A4, HTR1B
9mood disorder30.4HTR1B, TPH1, SLC6A4, SLC6A3, CNR1, DRD4
10schizophrenia30.4DRD5, DRD4, DRD3, DRD2, HTR1B, OPRK1
11attention deficit hyperactivity disorder30.3SLC6A3, DRD4
12nicotine dependence30.3SLC6A4, CHRNA5, CHRNB4, DRD4, DRD2
13cocaine dependence30.3DRD2, DRD3, SLC6A4, SLC6A3, MANEA, CHRNA5
14heroin dependence30.2DRD4, DRD2
15anxiety disorder30.2DRD2, CNR1, SLC6A3, SLC6A4, TPH1
16bulimia nervosa30.1SLC6A4, HTR1B
17eating disorder30.1CNR1, SLC6A3, SLC6A4
18opiate dependence29.9OPRM1
19panic disorder29.9TPH1, SLC6A4, DRD4
20morphine dependence29.9OPRD1, OPRK1
21withdrawal disorder29.9CNR1, OPRM1
22pathological gambling29.9DRD2, DRD3, DRD4, SLC6A3
23drug addiction29.9DRD2, DRD3, OPRK1, OPRD1, OPRM1, SLC6A3
24migraine29.9HTR1B, DRD2, DRD3, DRD4, DRD5, CNR1
25alzheimer's disease29.9DRD2, DRD3, DRD4, OPRK1, OPRD1, OPRM1
26dependent personality disorder10.6
27alexithymia10.3
28mental depression10.1
29sleep disorder10.1
30restless legs syndrome10.0DRD2
31neuroblastoma10.0OPRM1
32hypertension10.0SLC6A4
33myoclonus-dystonia10.0DRD2
34premature ejaculation10.0SLC6A4
35fibromyalgia10.0SLC6A4
36obsessive-compulsive personality disorder10.0SLC6A4
37alcoholic psychosis10.0SLC6A4
38delusional disorder10.0DRD4, DRD2
39multiple system atrophy10.0DRD2, SLC6A3
40narcolepsy10.0DRD2
41cannabis dependence10.0CNR1
42essential tremor10.0DRD3, SLC6A3
43endogenous depression10.0DRD3, SLC6A4
44social phobia10.0DRD2, SLC6A4
45striatonigral degeneration10.0SLC6A3, DRD2
46focal dystonia10.0DRD5, DRD2
47seasonal affective disorder10.0TPH1, SLC6A4, DRD4
48wilson disease10.0SLC6A3, DRD2
49movement disease10.0SLC6A3, DRD3, DRD2
50anorexia nervosa10.0DRD4, CNR1, TPH1, SLC6A4

Graphical network of the top 20 diseases related to Substance Dependence:



Diseases related to substance dependence

Clinical Features for Substance Dependence

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Drugs & Therapeutics for Substance Dependence

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Substance Dependence

Drug clinical trials:

Search ClinicalTrials for Substance Dependence

Search NIH Clinical Center for Substance Dependence

Search CenterWatch for Substance Dependence

Genetic Tests for Substance Dependence

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Anatomical Context for Substance Dependence

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32MalaCards
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MalaCards organs/tissues related to Substance Dependence:

32
Testes, Brain, Lung, Colon, Smooth muscle, Endothelial, Breast, Whole blood, Bone marrow, Eye, Bone, Skin, Prostate

Animal Models for Substance Dependence or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Substance Dependence:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.9DRD2, CNR1, SLC6A3, ADH7
2MP:00053759.9OPRM1, CNR1, DRD2, TPH1, DRD3
3MP:00053799.2OPRK1, SLC6A4, SLC6A3, PICK1, HTR1B, DRD2
4MP:00107719.1SLC6A4, CNR1, DRD2, NQO2, TPH1, CHRNB4
5MP:00053768.9SLC6A3, NQO2, DRD4, DRD2, CNR1, CHRNB4
6MP:00053788.8HTR1B, ADH7, SLC6A4, SLC6A3, TPH1, DRD2
7MP:00036318.8SLC6A3, ADH7, SLC6A4, DRD2, DRD3, DRD4
8MP:00053868.4OPRM1, NQO2, CNR1, CHRNA5, CHRNB4, HTR1B

Publications for Substance Dependence

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50PubMed
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Articles related to Substance Dependence:

(show top 50)    (show all 382)
idTitleAuthorsYear
1
Re-offending in forensic patients released from secure care: the role of antisocial/borderline personality disorder co-morbidity, substance dependence and severe childhood conduct disorder. (23371302)
2013
2
Resting-state activity in the left executive control network is associated with behavioral approach and is increased in substance dependence. (23428318)
2013
3
Seroprevalence of human immunodeficiency virus, hepatitis B surface antigen, and hepatitis C in substance dependents admitted in a tertiary hospital at Amritsar, India. (24309871)
2013
4
12-step affiliation and attendance following treatment for comorbid substance dependence and depression: a latent growth curve mediation model. (23327503)
2013
5
Treatment of comorbid substance dependence and posttraumatic stress disorder. (23925616)
2013
6
Cortical and subcortical volumes in adolescents with alcohol dependence but without substance or psychiatric comorbidities. (23916536)
2013
7
Depression and substance abuse and dependency in relation to current smoking status and frequency of smoking among nondaily and daily smokers. (24131166)
2013
8
Service use and barriers to mental health care among adults with major depression and comorbid substance dependence. (23728427)
2013
9
Profiles of executive functioning: associations with substance dependence and risky sexual behavior. (22775771)
2012
10
Relationship of alexithymia and dissociation with severity of borderline personality features in male substance-dependent inpatients. (22225788)
2012
11
Emotion regulation and substance use frequency in women with substance dependence and borderline personality disorder receiving dialectical behavior therapy. (21091162)
2011
12
Greater activation in left hemisphere language-related regions during simple judgment tasks among substance-dependent patients in treatment for alcoholism. (19951293)
2010
13
Adverse childhood events as risk factors for substance dependence: partial mediation by mood and anxiety disorders. (19720467)
2010
14
Mental disorders as risk factors for later substance dependence: estimates of optimal prevention and treatment benefits. (19046473)
2009
15
Substance dependence and remission in schizophrenia: A comparison of schizophrenia and affective disorders. (19375237)
2009
16
Non-treatment laboratory stress- and cue-reactivity studies are associated with decreased substance use among drug-dependent individuals. (19717245)
2009
17
Substance-dependence rehab treatment in Thailand: a meta analysis. (20232564)
2009
18
Trauma, dissociation, and substance dependence in an adolescent male. (19205967)
2009
19
Characteristics and outcomes of doctors in a substance dependence monitoring programme in Canada: prospective descriptive study. (18981018)
2008
20
Hypericum perforatum and substance dependence: a review. (18350514)
2008
21
Comorbidity of substance dependence and depression: role of life stress and self-efficacy in sustaining abstinence. (18298230)
2008
22
Explaining the escalation of drug use in substance dependence: models and appropriate animal laboratory tests. (17570954)
2007
23
Mullerian inhibiting substance regulates androgen-induced gene expression and growth in prostate cancer cells through a nuclear factor-kappaB-dependent Smad-independent mechanism. (16740653)
2006
24
The impact of substance dependence on HIV sexual risk-reduction among men with severe mental illness. (16036249)
2005
25
From basic research to public health policy: WHO report on the neuroscience of substance dependence. (15345278)
2004
26
Potential benefits of quetiapine in the treatment of substance dependence disorders. (15644986)
2004
27
A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence. (14679582)
2004
28
Ligand binding and polymerization characteristics of human milk folate binding protein depend on concentration of purified protein and presence of amphiphatic substances. (14570378)
2003
29
GABA systems, benzodiazepines, and substance dependence. (12662132)
2003
30
Ephedrine-type alkaloid-containing dietary supplements and substance dependence. (14597686)
2003
31
Choice, rationality, and substance dependence. (12189083)
2002
32
Effects of major depression on remission and relapse of substance dependence. (11926938)
2002
33
Vulnerability factors for homelessness associated with substance dependence in a community sample of homeless adults. (12211359)
2002
34
The D3 dopamine receptor and substance dependence. (11681590)
2001
35
Retention in substance dependence treatment: the relevance of in-treatment factors. (11672639)
2001
36
Antisociality, substance dependence, and the DRD5 gene: a preliminary study. (11054773)
2000
37
Cocaine dependence with and without post-traumatic stress disorder: a comparison of substance use, trauma history and psychiatric comorbidity. (10914293)
2000
38
Substance dependence and other psychiatric disorders among drug dependent subjects: race and gender correlates. (10934573)
2000
39
The experience of acupuncture for treatment of substance dependence. (12462821)
2000
40
Integrating skills training and motivational therapies. Implications for the treatment of substance dependence. (10435249)
1999
41
Substance dependence and eating disorders: impact of sequence on comorbidity. (10509613)
1999
42
Laboratory measurement of adaptive behavior change in humans with a history of substance dependence. (9787997)
1998
43
Substance dependence. (9713241)
1998
44
Time-dependent, spontaneous release of white cell- and platelet-derived bioactive substances from stored human blood. (8937404)
1996
45
A study of comorbidity in psychoactive substance dependence patients. (21743688)
1994
46
Should tolerance and withdrawal be required for substance dependence disorders? (7988354)
1994
47
Purification of proteinase-like and Na+/K(+)-ATPase stimulating substance from plasma of insulin-dependent diabetics and its identification as alpha 1-antitrypsin. (1319211)
1992
48
Intraspinal release of substance P and calcitonin gene-related peptide during opiate dependence and withdrawal. (1717887)
1991
49
Dual diagnosis: psychoactive substance dependence and the personality disorders. (2668480)
1989
50
Proposed changes in DSM-III substance dependence criteria. (3812810)
1987

Genetic Variations for Substance Dependence

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Expression for genes affiliated with Substance Dependence

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Substance Dependence

Search GEO for disease gene expression data for Substance Dependence.

Pathways for genes affiliated with Substance Dependence

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53Reactome, 51QIAGEN, 12EMD Millipore, 29KEGG, 49PharmGKB, 37NCBI BioSystems Database
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Pathways related to Substance Dependence according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1CHRNB4, CHRNA5
210.0DRD5, DRD2, DRD3, DRD4
310.0DRD2, DRD5, DRD4, DRD3
4
Hide members
10.0DRD5, DRD3, DRD4, DRD2
5
Hide members
10.0ADH7, ADH1A, ADH4
6
Hide members
10.0ADH7, ADH4, ADH1A
7
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10.0ADH4, ADH7, ADH1A
8
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10.0ADH4, ADH7, ADH1A
9
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10.0ADH4, ADH7, ADH1A
10
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9.9CHRNA5, DRD4, DRD3, DRD2
11
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9.8PICK1, CHRNB4, CHRNA5, SLC6A3
12
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9.7HTR1B, DRD2, DRD3, DRD4, DRD5, SLC6A4
13
Hide members
9.2SLC6A4, HTR1B, DRD2, DRD3, DRD4, DRD5
14
Hide members
9.0OPRD1, OPRK1, DRD5, DRD3, CNR1, DRD2
15
Hide members
8.9CNR1, CHRNA5, OPRM1, OPRD1, OPRK1, DRD5

Compounds for genes affiliated with Substance Dependence

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28IUPHAR, 44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Substance Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 263)
idCompoundScoreTop Affiliating Genes
1(+)-butaclamol28 4411.3DRD2, DRD5, DRD4, DRD3
2piperazine44 1111.2DRD2, DRD3, SLC6A3, OPRM1, DRD4
3rotigotine44 28 1112.2DRD5, DRD3, DRD4, DRD2
4raclopride44 2811.2DRD4, DRD3, DRD2, SLC6A3
5methylphenidate44 49 1112.2DRD4, SLC6A3, SLC6A4, DRD5, DRD2
6ropinirole44 1111.2HTR1B, DRD2, DRD3, DRD4, DRD5
7lisuride28 44 1112.2DRD3, DRD5, HTR1B, DRD4, DRD2
8quinpirole44 2811.2DRD2, SLC6A3, CNR1, DRD4, DRD3
9pergolide28 44 1112.2HTR1B, DRD2, DRD3, DRD4, DRD5
10cabergoline28 44 1112.2HTR1B, DRD5, DRD4, DRD3, DRD2
11aripiprazole28 49 44 11 2414.2HTR1B, DRD2, DRD3, DRD4, DRD5
12roxindole28 4411.2HTR1B, DRD4, DRD3, DRD2
13pramipexole44 49 28 1113.1DRD2, HTR1B, SLC6A3, DRD5, DRD4, DRD3
14ziprasidone49 28 44 1113.1DRD5, DRD4, DRD2, DRD3, HTR1B
15bupropion44 49 11 2413.1CNR1, SLC6A3, DRD3, SLC6A4, DRD2
16spiperone28 4411.1DRD2, DRD3, DRD4, DRD5
17phencyclidine44 28 1112.1DRD2, DRD4, SLC6A3, OPRM1, OPRD1
18quetiapine44 49 28 11 2414.1SLC6A3, DRD5, DRD4, DRD3, DRD2, HTR1B
19terguride28 4411.1HTR1B, DRD4, DRD3, DRD2
20maoa4410.1HTR1B, SLC6A3, SLC6A4, TPH1, DRD2, DRD4
21paroxetine44 49 28 1113.1HTR1B, DRD3, DRD4, SLC6A3, SLC6A4, TPH1
22bromocriptine28 44 1112.1HTR1B, DRD2, DRD3, DRD4, SLC6A3, DRD5
23olanzapine49 44 28 11 2414.1DRD2, DRD3, DRD4, DRD5, SLC6A3, HTR1B
24risperidone28 44 49 59 11 2415.1DRD2, DRD4, SLC6A3, HTR1B, DRD3, SLC6A4
25Tapentadol1110.1OPRK1, SLC6A4, OPRM1, OPRD1
26fluoxetine49 44 28 1113.0SLC6A4, DRD2, CNR1, SLC6A3, HTR1B, TPH1
27apomorphine44 28 1112.0CNR1, DRD4, DRD5, DRD3, DRD2, HTR1B
28tramadol44 49 1112.0OPRD1, OPRK1, SLC6A4, OPRM1
29haloperidol44 28 2 49 1114.0OPRM1, DRD2, SLC6A4, SLC6A3, DRD5, DRD4
30nmda44 2811.0SLC6A3, PICK1, OPRK1, OPRD1, OPRM1, CNR1
31normorphine2810.0OPRK1, OPRD1, OPRM1
32amphetamine44 1111.0DRD2, SLC6A3, OPRK1, CNR1, DRD4, SLC6A4
336-hydroxydopamine449.9SLC6A3, OPRM1, DRD4, DRD3, DRD2
34baclofen44 1110.9CNR1, OPRM1, SLC6A3, OPRD1
35sulpiride44 28 1111.9SLC6A3, DRD4, DRD2, DRD3
36opiate449.9SLC6A3, DRD3, OPRM1, OPRK1, OPRD1, SLC6A4
37morphine44 49 28 1112.9OPRM1, OPRK1, CNR1, DRD2, OPRD1, SLC6A3
38methamphetamine44 49 1111.7PICK1, TPH1, SLC6A4, SLC6A3, OPRM1, OPRD1
395-hydroxytryptamine449.7SLC6A3, SLC6A4, TPH1, CNR1, OPRM1, OPRD1
40heroin44 49 1111.7OPRM1, CNR1, SLC6A3, SLC6A4, DRD3, OPRK1
41gaba449.6TPH1, SLC6A4, SLC6A3, CNR1, OPRM1, DRD4
42levodopa44 1110.6OPRK1, TPH1, SLC6A3, CNR1, OPRM1, DRD5
43cyclic amp44 2410.5OPRK1, DRD5, DRD4, DRD3, HTR1B, CNR1
44cocaine44 1110.5DRD2, HTR1B, DRD3, DRD4, SLC6A4, SLC6A3
45clozapine44 28 49 1112.5DRD3, OPRD1, NQO2, SLC6A3, SLC6A4, DRD4
46norepinephrine44 11 2411.4DRD3, DRD2, DRD4, DRD5, TPH1, SLC6A4
47glutamate449.3SLC6A3, TPH1, DRD3, CNR1, PICK1, OPRD1
48nicotine44 49 28 1112.2OPRD1, CNR1, TPH1, SLC6A4, SLC6A3, DRD2
49acetylcholine44 49 28 11 2413.2SLC6A3, CNR1, OPRM1, TPH1, OPRK1, OPRD1
50dopamine44 28 11 2412.1OPRK1, CNR1, SLC6A3, SLC6A4, TPH1, DRD5

GO Terms for genes affiliated with Substance Dependence

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16Gene Ontology
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Cellular components related to Substance Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:00589210.1CHRNA5, CHRNB4
2integral to plasma membraneGO:0058878.7SLC6A4, SLC6A3, CNR1, CHRNB4, OPRM1, OPRD1
3plasma membraneGO:0058868.1SLC6A4, HTR1B, DRD2, SLC6A3, CNR1, CHRNA5

Biological processes related to Substance Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of voltage-gated calcium channel activityGO:190138610.6DRD2, DRD4
2negative regulation of dopamine receptor signaling pathwayGO:06016010.6DRD2, DRD3
3positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.6DRD2, DRD4
4response to histamineGO:03477610.6DRD2, DRD3, DRD4
5regulation of dopamine uptake involved in synaptic transmissionGO:05158410.6DRD2, DRD3
6adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.5DRD2, DRD3, DRD4
7adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.5DRD3, DRD5, OPRM1
8dopamine metabolic processGO:04241710.5DRD2, DRD3, DRD4
9behavioral response to ethanolGO:04814910.5OPRM1, DRD4, DRD2
10behavioral response to cocaineGO:04814810.5DRD3, DRD2, DRD4
11regulation of cAMP metabolic processGO:03081410.5DRD3, DRD2
12negative regulation of protein secretionGO:05070910.5DRD4, DRD3, DRD2
13arachidonic acid secretionGO:05048210.5DRD2, DRD3, DRD4
14response to morphineGO:04327810.5CNR1, DRD3, DRD2
15prepulse inhibitionGO:06013410.5SLC6A3, DRD3, DRD2
16regulation of dopamine secretionGO:01405910.5HTR1B, DRD2, DRD3
17monoamine transportGO:01584410.5SLC6A4, SLC6A3, PICK1
18reduction of cytosolic calcium ion concentrationGO:05148110.5DRD2, OPRM1
19social behaviorGO:03517610.5DRD3, DRD4, SLC6A4
20G-protein coupled receptor internalizationGO:00203110.5DRD3, DRD2, HTR1B
21response to nicotineGO:03509410.5DRD2, CNR1, SLC6A3
22synaptic transmission, dopaminergicGO:00196310.5DRD5, DRD4, DRD3, DRD2
23response to amphetamineGO:00197510.4DRD2, DRD3, DRD4, DRD5
24negative regulation of blood pressureGO:04577610.4CNR1, DRD5, DRD3, DRD2
25phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.4DRD2, DRD5
26negative regulation of adenylate cyclase activityGO:00719410.4OPRM1, DRD4, DRD3, DRD2
27adenohypophysis developmentGO:02198410.4DRD2, SLC6A3
28behaviorGO:00761010.4CNR1, OPRM1, OPRK1
29regulation of dopamine metabolic processGO:04205310.4DRD4, SLC6A3
30alcohol metabolic processGO:00606610.4ADH1A, ADH4
31opioid receptor signaling pathwayGO:03800310.4OPRK1, OPRD1
32cellular calcium ion homeostasisGO:00687410.4DRD5, DRD4, DRD3, DRD2
33regulation of synaptic transmission, GABAergicGO:03222810.4DRD2, CNR1
34ethanol oxidationGO:00606910.4ADH1A, ADH7, ADH4
35memoryGO:00761310.4SLC6A4, NQO2, CNR1
36behavioral response to nicotineGO:03509510.4CHRNB4, CHRNA5
37sensory perception of painGO:01923310.4OPRK1, OPRM1, CNR1
38phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00720010.3OPRK1, OPRD1, OPRM1
39adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00719310.3OPRM1, OPRD1, OPRK1
40G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.3HTR1B, OPRD1, OPRM1, CNR1
41negative regulation of synaptic transmission, glutamatergicGO:05196710.3DRD2, HTR1B
42negative regulation of cAMP biosynthetic processGO:03081810.3HTR1B, DRD4
43response to ethanolGO:04547110.2HTR1B, DRD3, CNR1, SLC6A3, ADH7
44sensory perceptionGO:00760010.2OPRK1, OPRM1
45response to cocaineGO:04222010.2SLC6A3, CNR1, DRD5, DRD3, DRD2, HTR1B
46regulation of behaviorGO:05079510.1HTR1B, OPRM1
47locomotory behaviorGO:00762610.1DRD2, DRD3, OPRK1, OPRM1, CHRNB4, SLC6A3
48response to drugGO:04249310.0SLC6A4, SLC6A3, DRD3, DRD2
49response to iron ionGO:0100399.9DRD2, SLC6A3
50synaptic transmissionGO:0072689.8HTR1B, DRD5, OPRK1, PICK1, CHRNB4, CHRNA5

Molecular functions related to Substance Dependence according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activityGO:00495210.4DRD5, DRD4
2dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.3DRD2, DRD3, DRD4
3monoamine transmembrane transporter activityGO:00850410.3SLC6A4, SLC6A3
4ligand-gated ion channel activityGO:01527610.2CHRNA5, CHRNB4
5retinol bindingGO:01984110.2ADH4, ADH7
6alcohol dehydrogenase activity, zinc-dependentGO:00402410.2ADH7, ADH4, ADH1A
7alcohol dehydrogenase (NAD) activityGO:00402210.2ADH1A, ADH4, ADH7
8dopamine bindingGO:03524010.1SLC6A3, DRD5, DRD4, DRD3, DRD2
9acetylcholine-activated cation-selective channel activityGO:00488910.1CHRNA5, CHRNB4
10acetylcholine receptor activityGO:01546410.0CHRNA5, CHRNB4
11drug bindingGO:0081449.9HTR1B, DRD2, DRD3, DRD4, CNR1, SLC6A3
12retinol dehydrogenase activityGO:0047459.9ADH7, ADH4

Products for genes affiliated with Substance Dependence

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Substance Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet