MCID: SBS004
MIFTS: 40

Substance Dependence malady

Summaries for Substance Dependence

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Disease Ontology:9 A substance-related disorder that involves the continued use of alcohol or other drugs despite despite problems related to use of the substance.

MalaCards based summary: Substance Dependence is related to drug dependence and personality disorder. An important gene associated with Substance Dependence is DRD5 (dopamine receptor D5), and among its related pathways are GPCRs, Other and Hypothetical Network for Drug Addiction. The compounds cis flupentixol and (-)-sulpiride have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotypes are taste/olfaction and adipose tissue.

Wikipedia:63 Substance dependence also known as drug dependence is an adaptive state that develops from repeated drug... more...

Aliases & Classifications for Substance Dependence

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Substance Dependence, Aliases & Descriptions:

Name: Substance Dependence 9 11 43 60


External Ids:

Disease Ontology9 DOID:9973
NCIt38 C35458

Related Diseases for Substance Dependence

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Diseases related to Substance Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1drug dependence30.5DRD2, DRD3, CNR1
2personality disorder30.5DRD2, DRD3, DRD4, TPH1
3conduct disorder30.4DRD2, DRD5, DRD4
4attention deficit-hyperactivity disorder30.2DRD4, DRD5, DRD2
5schizophrenia30.2DRD2, DRD3, DRD4
6cocaine dependence30.2DRD3, DRD2
7drug addiction30.1DRD3, DRD2
8pathological gambling30.0DRD4, DRD3, DRD2
9panic disorder29.9DRD4, TPH1
10anxiety disorder29.9TPH1, CNR1, DRD2
11bipolar disorder29.6TPH1, CNR1, DRD4, DRD5, DRD3, DRD2
12substance abuse29.6CNR1, DRD4, DRD3, DRD2
13alcohol dependence29.5DRD2, DRD3, DRD4, CNR1, TPH1
14mood disorder29.4TPH1, CNR1, DRD4, DRD3, DRD2
15migraine28.8DRD2, TPH1, CNR1, DRD4, DRD5, DRD3
16antisocial personality disorder10.4
17alexithymia10.4
18borderline personality disorder10.3
19oppositional defiant disorder10.2DRD4
20focal dystonia10.2DRD5, DRD2
21bulimia nervosa10.1
22eating disorder10.1
23chronic pain10.1
24opioid dependence10.1DRD2, DRD3
25alcohol abuse10.1DRD2, DRD3
26movement disease10.1DRD2, DRD3
27delusional disorder10.0DRD2, DRD4
28nicotine dependence, protection against10.0DRD2, TPH1
29major depressive disorder and accelerated response to antidepressant drug treatment10.0DRD4, TPH1
30heroin dependence10.0DRD4, DRD2
31hiv-110.0
32hepatitis10.0
33hepatitis b10.0
34hepatitis c10.0
35dependent personality disorder10.0
36phobic disorder10.0
37sleep disorder10.0
38sickle cell disease10.0
39hyperprolactinemia9.9DRD4, DRD2
40parkinson disease, late-onset9.9CNR1, DRD3, DRD2
41gilles de la tourette syndrome9.8DRD2, DRD5, DRD4
42huntington disease9.8CNR1, DRD2
43melanoma9.8DRD2, DRD3, TPH1
44anorexia nervosa9.8TPH1, CNR1, DRD4
45obesity9.6CNR1, DRD4, DRD2
46obsessive-compulsive disorder9.6TPH1, DRD4, DRD3, DRD2
47psychotic disorder9.4DRD2, DRD3, DRD4, CNR1, TPH1
48alzheimer disease9.3TPH1, CNR1, DRD4, DRD3, DRD2

Graphical network of the top 20 diseases related to Substance Dependence:



Diseases related to substance dependence

Symptoms for Substance Dependence

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Drugs & Therapeutics for Substance Dependence

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Drug clinical trials:

Search ClinicalTrials for Substance Dependence

Search NIH Clinical Center for Substance Dependence

Genetic Tests for Substance Dependence

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Anatomical Context for Substance Dependence

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MalaCards organs/tissues related to Substance Dependence:

31
Brain, Testes, Eye

Animal Models for Substance Dependence or affiliated genes

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MGI Mouse Phenotypes related to Substance Dependence:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.3DRD2, CNR1
2MP:00053758.5TPH1, CNR1, DRD3, DRD2
3MP:00053858.3DRD2, TPH1, DRD5, DRD3
4MP:00053867.6CNR1, TPH1, DRD4, DRD3, DRD2
5MP:00036317.6DRD2, CNR1, DRD4, DRD3, DRD5
6MP:00053767.4DRD2, DRD3, DRD4, CNR1, TPH1

Publications for Substance Dependence

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Articles related to Substance Dependence:

(show top 50)    (show all 345)
idTitleAuthorsYear
1
Relationship between drug dreams, affect, and craving during treatment for substance dependence. (25700139)
2015
2
An Examination of a Proposed DSM-IV Pathological Gambling Hierarchy in a Treatment Seeking Population: Similarities with Substance Dependence and Evidence for Three Classification Systems. (24627139)
2014
3
Using spiritually modified cognitive-behavioral therapy in substance dependence treatment: therapists' and clients' perceptions of the presumed benefits and limitations. (25369720)
2014
4
Personal Network Recovery Enablers and Relapse Risks for Women With Substance Dependence. (25231945)
2014
5
Experiences of mothers with substance dependence: Informing the development of parenting support. (25280136)
2014
6
Recovery of neurocognitive functions following sustained abstinence after substance dependence and implications for treatment. (25240109)
2014
7
TRICARE; removal of the prohibition to use addictive drugs in the maintenance treatment of substance dependence in TRICARE beneficiaries. Final rule. (24156132)
2013
8
Re-offending in forensic patients released from secure care: the role of antisocial/borderline personality disorder co-morbidity, substance dependence and severe childhood conduct disorder. (23371302)
2013
9
Effects of working memory load, a history of conduct disorder, and sex on decision making in substance dependent individuals. (24011986)
2013
10
Striatal dopamine release in schizophrenia comorbid with substance dependence. (22869037)
2013
11
Impact of Physical Health on Treatment for Co-occurring Depression and Substance Dependence. (24223036)
2013
12
Poor sleep at baseline predicts worse mood outcomes in patients with co-occurring bipolar disorder and substance dependence. (22313797)
2012
13
Integrated exposure-based therapy for co-occurring posttraumatic stress disorder and substance dependence: a randomized controlled trial. (22893166)
2012
14
Developmental momentum toward substance dependence: natural histories and pliability of risk factors in youth experiencing chronic stress. (22257754)
2012
15
Predictors of retention in the 'voluntary' and 'quasi-compulsory' treatment of substance dependence in europe. (21228594)
2011
16
Non-suicidal self-injury by intravenous application of nicotine in a patient with borderline personality disorder resulting in substance dependence. (21306599)
2011
17
Remission from substance dependence in U.S. Whites, African Americans, and Latinos. (21161807)
2010
18
Greater activation in left hemisphere language-related regions during simple judgment tasks among substance-dependent patients in treatment for alcoholism. (19951293)
2010
19
Time to Relapse Questionnaire (TRQ): a measure of sudden relapse in substance dependence. (20465371)
2010
20
Mental disorders as risk factors for later substance dependence: estimates of optimal prevention and treatment benefits. (19046473)
2009
21
Substance dependence and remission in schizophrenia: A comparison of schizophrenia and affective disorders. (19375237)
2009
22
Treatment of Co-occurring Depression and Substance Dependence: Using Meta-analysis to Guide Clinical Recommendations. (19668349)
2008
23
Drug-dependent boys are more depressed compared to girls: a comorbidity study of substance dependence and mental disorders. (18552492)
2008
24
The relationship of cumulative and proximal adversity to onset of substance dependence symptoms in two American Indian communities. (17640829)
2007
25
Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence. (16741937)
2006
26
Multiple substance dependence and course of alcoholism among Alaska native men and women. (16603457)
2006
27
Antisocial personality disorder in Turkish substance dependent patients and its relationship with anxiety, depression and a history of childhood abuse. (16910384)
2006
28
Comments on "Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans". (15389767)
2005
29
Co-occurring substance dependence and depression: practical implications and next questions. (16367973)
2005
30
Review: antidepressants are moderately effective in people with depression and a substance dependence disorder. (15504796)
2004
31
From basic research to public health policy: WHO report on the neuroscience of substance dependence. (15345278)
2004
32
Mate similarity for substance dependence and antisocial personality disorder symptoms among parents of patients and controls. (15276222)
2004
33
WHO report calls for new approach to substance dependence. (15031236)
2004
34
Pain management and symptoms of substance dependence among patients with sickle cell disease. (12948577)
2003
35
High- and low-structure treatments for substance dependence: role of learned helplessness. (14510041)
2003
36
A comparison of personality characteristics of patients with posttraumatic stress disorders and substance dependence: preliminary findings. (14504572)
2003
37
Choice, rationality, and substance dependence. (12189083)
2002
38
Etiologic connections among substance dependence, antisocial behavior, and personality: modeling the externalizing spectrum. (12150417)
2002
39
Effects of major depression on remission and relapse of substance dependence. (11926938)
2002
40
Antisociality, substance dependence, and the DRD5 gene: a preliminary study. (11054773)
2000
41
Substance dependence and the use of pro re nata anxiolytic/hypnotic drugs in a hospital setting. (10890298)
2000
42
Effects of substance dependence on outcomes of patients in a randomized trial of two case management models. (10783183)
2000
43
Clinical implications for four drugs of the DSM-IV distinction between substance dependence with and without a physiological component. (9892296)
1999
44
Genetic studies of alcoholism and substance dependence. (10441565)
1999
45
Effect of gender, treatment site and psychiatric comorbidity on quality of life outcome in substance dependence. (10189514)
1999
46
"Seeking safety": outcome of a new cognitive-behavioral psychotherapy for women with posttraumatic stress disorder and substance dependence. (9690186)
1998
47
Twin studies of adult psychiatric and substance dependence disorders: are they biased by differences in the environmental experiences of monozygotic and dizygotic twins in childhood and adolescence? (9626718)
1998
48
Quantitative electroencephalographic differences associated with alcohol, cocaine, heroin and dual-substance dependence. (9246556)
1997
49
D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects. (9345090)
1997
50
A preliminary investigation of alexithymia in men with psychoactive substance dependence. (2386256)
1990

Variations for Substance Dependence

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Expression for genes affiliated with Substance Dependence

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Search GEO for disease gene expression data for Substance Dependence.

Pathways for genes affiliated with Substance Dependence

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Pathways related to Substance Dependence according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1DRD3, DRD4
29.1DRD2, DRD4
3
Show member pathways
Nicotine Activity on Dopaminergic Neurons36
8.6DRD2, DRD3, DRD4
4
Show member pathways
8.2DRD4, DRD5, DRD3, DRD2
5
Show member pathways
8.2DRD4, DRD5, DRD3, DRD2
68.2DRD4, DRD5, DRD3, DRD2
7
Show member pathways
7.6DRD2, DRD3, DRD5, DRD4, CNR1
8
Show member pathways
7.6CNR1, DRD4, DRD5, DRD3, DRD2
9
Show member pathways
7.1DRD2, DRD3, DRD5, DRD4, CNR1, TPH1

Compounds for genes affiliated with Substance Dependence

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Sources:
28IUPHAR, 43Novoseek, 49PharmGKB, 12DrugBank, 2BitterDB, 24HMDB
See all sources

Compounds related to Substance Dependence according to GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1cis flupentixol289.4DRD2, DRD5, DRD3
2(-)-sulpiride289.0DRD4, DRD2, DRD3
3(+)-sulpiride289.0DRD2, DRD3, DRD4
4eticlopride43 2810.0DRD4, DRD3, DRD2
5fluphenazine28 43 49 1212.0DRD2, DRD5, DRD4
6nemonapride43 49 2811.0DRD4, DRD2, DRD3
7sch 23390439.0DRD3, DRD2, DRD4
8remoxipride43 129.9DRD2, DRD3, DRD4
9piribedil28 439.9DRD4, DRD2, DRD3
10benzamide2 439.9DRD3, DRD2, DRD4
11methylphenidate43 49 1210.9DRD4, DRD5, DRD2
12raclopride43 289.9DRD2, DRD3, DRD4
13roxindole28 439.9DRD2, DRD4, DRD3
14terguride43 289.9DRD2, DRD3, DRD4
15piperazine43 129.8DRD2, DRD3, DRD4
16sulpiride43 28 1210.8DRD2, DRD4, DRD3
17bupropion49 43 24 1211.8DRD3, CNR1, DRD2
18maoa438.8TPH1, DRD4, DRD2
19(+)-butaclamol43 289.6DRD4, DRD2, DRD3, DRD5
20rotigotine28 43 1210.6DRD2, DRD3, DRD4, DRD5
21spiperone43 289.6DRD2, DRD3, DRD5, DRD4
22ropinirole43 129.6DRD4, DRD5, DRD2, DRD3
23lisuride43 28 1210.6DRD3, DRD4, DRD2, DRD5
24pergolide43 28 1210.6DRD2, DRD4, DRD3, DRD5
25pramipexole43 28 49 1211.6DRD3, DRD4, DRD2, DRD5
26cabergoline43 28 1210.6DRD3, DRD5, DRD4, DRD2
27paliperidone43 129.6DRD3, DRD4, DRD2
28aripiprazole28 43 49 24 1212.6DRD2, DRD4, DRD3, DRD5
29ziprasidone28 49 43 1211.6DRD5, DRD3, DRD2, DRD4
30quetiapine43 49 28 24 1212.6DRD5, DRD4, DRD3, DRD2
31chlorpromazine28 43 49 1211.6DRD5, DRD4, DRD3, DRD2
32bromocriptine43 28 1210.6DRD4, DRD5, DRD3, DRD2
33catecholamine438.5DRD5, DRD4, DRD3, TPH1
34methamphetamine43 49 1210.5DRD3, TPH1, DRD4, DRD2
35iloperidone49 43 28 1211.5DRD2, DRD4, DRD3
36haloperidol43 49 28 2 1212.5DRD5, DRD3, DRD2, DRD4
37amphetamine43 49 1210.4DRD2, DRD4, CNR1, TPH1
38quinpirole43 289.4CNR1, DRD4, DRD3, DRD2
39heroin43 49 1210.4DRD4, CNR1, DRD2, DRD3
40asenapine28 129.3DRD4, DRD2, DRD3
41cocaine43 129.2CNR1, DRD4, DRD2, DRD3
425-hydroxytryptamine438.1DRD4, DRD2, TPH1, CNR1
43apomorphine28 43 1210.0DRD2, CNR1, DRD4, DRD5, DRD3
44olanzapine43 49 28 24 1212.0CNR1, DRD4, DRD5, DRD3, DRD2
45clozapine43 28 49 1211.0DRD2, DRD4, DRD5, DRD3, CNR1
46nicotine43 28 49 1210.9TPH1, CNR1, DRD4, DRD3, DRD2
47cyclic amp43 248.8DRD3, CNR1, DRD4, DRD5, TPH1
48levodopa43 128.6TPH1, CNR1, DRD4, DRD3, DRD2, DRD5
49norepinephrine43 24 129.6TPH1, CNR1, DRD4, DRD5, DRD3, DRD2
50dopamine43 28 24 1210.5DRD2, DRD3, DRD5, DRD4, CNR1, TPH1

GO Terms for genes affiliated with Substance Dependence

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Cellular components related to Substance Dependence according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicleGO:00301399.3DRD2, DRD3
2dendritic spineGO:00431979.1DRD2, DRD4
3integral component of plasma membraneGO:00058877.6DRD2, DRD3, DRD5, DRD4, CNR1
4plasma membraneGO:00058867.3CNR1, DRD4, DRD5, DRD3, DRD2

Biological processes related to Substance Dependence according to GeneCards Suite gene sharing:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1phospholipase C-activating dopamine receptor signaling pathwayGO:00601589.9DRD5, DRD2
2adenylate cyclase-activating dopamine receptor signaling pathwayGO:00071919.8DRD5, DRD3
3regulation of locomotion involved in locomotory behaviorGO:00903259.8DRD2, DRD3
4negative regulation of dopamine receptor signaling pathwayGO:00601609.8DRD3, DRD2
5regulation of dopamine uptake involved in synaptic transmissionGO:00515849.8DRD3, DRD2
6associative learningGO:00083069.8DRD2, DRD5
7regulation of cAMP metabolic processGO:00308149.8DRD2, DRD3
8G-protein coupled receptor internalizationGO:00020319.7DRD2, DRD3
9prepulse inhibitionGO:00601349.7DRD2, DRD3
10negative regulation of dopamine secretionGO:00336029.7CNR1, DRD2
11positive regulation of renal sodium excretionGO:00358159.7DRD3, DRD2
12circadian regulation of gene expressionGO:00329229.6DRD2, DRD3
13regulation of synaptic transmission, GABAergicGO:00322289.6DRD2, CNR1
14negative regulation of protein kinase B signalingGO:00518989.6DRD3, DRD2
15positive regulation of cytokinesisGO:00324679.5DRD3, DRD2
16response to nicotineGO:00350949.5CNR1, DRD2
17positive regulation of dopamine uptake involved in synaptic transmissionGO:00515869.5DRD4, DRD2
18negative regulation of voltage-gated calcium channel activityGO:019013869.5DRD2, DRD4
19visual learningGO:00085429.4DRD2, DRD3
20behavioral response to ethanolGO:00481499.4DRD2, DRD4
21response to ethanolGO:00454719.3DRD3, CNR1
22social behaviorGO:00351769.2DRD3, DRD4
23response to morphineGO:00432789.2DRD2, DRD3, CNR1
24locomotory behaviorGO:00076269.1DRD2, DRD3
25circadian rhythmGO:00076239.1TPH1, DRD4
26response to histamineGO:00347769.0DRD2, DRD3, DRD4
27adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00071959.0DRD4, DRD3, DRD2
28dopamine metabolic processGO:00424179.0DRD2, DRD3, DRD4
29negative regulation of protein secretionGO:00507099.0DRD4, DRD3, DRD2
30behavioral response to cocaineGO:00481489.0DRD2, DRD3, DRD4
31arachidonic acid secretionGO:00504829.0DRD4, DRD3, DRD2
32negative regulation of adenylate cyclase activityGO:00071949.0DRD4, DRD3, DRD2
33response to cocaineGO:00422208.8CNR1, DRD5, DRD3, DRD2
34negative regulation of blood pressureGO:00457768.8DRD2, DRD3, DRD5, CNR1
35synaptic transmission, dopaminergicGO:00019638.6DRD2, DRD3, DRD5, DRD4
36response to amphetamineGO:00019758.6DRD4, DRD5, DRD3, DRD2
37cellular calcium ion homeostasisGO:00068748.6DRD4, DRD5, DRD3, DRD2

Molecular functions related to Substance Dependence according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1potassium channel regulator activityGO:00154599.1DRD2, DRD4
2dopamine neurotransmitter receptor activityGO:00049528.9DRD5, DRD4
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00015918.6DRD2, DRD3, DRD4
4dopamine bindingGO:00352408.3DRD2, DRD3, DRD5, DRD4
5drug bindingGO:00081447.9CNR1, DRD4, DRD3, DRD2

Products for genes affiliated with Substance Dependence

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Sources for Substance Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet