MCID: SBS004
MIFTS: 54

Substance Dependence malady

Summaries for Substance Dependence

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A substance-related disorder that involves the continued use of alcohol or other drugs despite despite problems related to use of the substance.

MalaCards: Substance Dependence is related to personality disorder and drug dependence. An important gene associated with Substance Dependence is DRD5 (dopamine receptor D5), and among its related pathways are Presynaptic nicotinic acetylcholine receptors and Dopamine receptors. The compounds (+)-butaclamol and piperazine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and lung, and related mouse phenotypes are taste/olfaction and adipose tissue.

Wikipedia:63 Substance dependence, commonly called drug addiction, is a compulsive need to use drugs in order to... more...

Aliases & Classifications for Substance Dependence

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

substance dependence 8 10 44 60


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Disease Ontology8 DOID:9973
NCIt39 C35458

Related Diseases for Substance Dependence

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17GeneCards, 18GeneDecks
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Diseases related to Substance Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder30.9TPH1, SLC6A4, SLC6A3, DRD4, DRD3, DRD2
2drug dependence30.9SLC6A3, CNR1, OPRM1, OPRD1, OPRK1, DRD3
3alcohol dependence30.8ADH7, ADH4, ADH1A, SLC6A4, CNR1, CHRNA5
4bipolar disorder30.7TPH1, SLC6A4
5antisocial personality disorder30.6SLC6A4, SLC6A3, DRD2, HTR1B
6substance abuse30.6ADH4, SLC6A4, SLC6A3, CNR1, OPRM1, DRD4
7conduct disorder30.5DRD2, DRD4, DRD5, SLC6A3, SLC6A4
8borderline personality disorder30.5TPH1, SLC6A4, HTR1B
9mood disorder30.4HTR1B, TPH1, SLC6A4, SLC6A3, CNR1, DRD4
10schizophrenia30.4DRD5, DRD4, DRD3, DRD2, HTR1B, OPRK1
11attention deficit hyperactivity disorder30.3SLC6A3, DRD4
12nicotine dependence30.3SLC6A4, CHRNA5, CHRNB4, DRD4, DRD2
13cocaine dependence30.3DRD2, DRD3, SLC6A4, SLC6A3, MANEA, CHRNA5
14heroin dependence30.2DRD4, DRD2
15anxiety disorder30.2DRD2, CNR1, SLC6A3, SLC6A4, TPH1
16bulimia nervosa30.1SLC6A4, HTR1B
17eating disorder30.1CNR1, SLC6A3, SLC6A4
18opiate dependence29.9OPRM1
19panic disorder29.9TPH1, SLC6A4, DRD4
20morphine dependence29.9OPRD1, OPRK1
21withdrawal disorder29.9CNR1, OPRM1
22pathological gambling29.9DRD2, DRD3, DRD4, SLC6A3
23drug addiction29.9DRD2, DRD3, OPRK1, OPRD1, OPRM1, SLC6A3
24migraine29.9HTR1B, DRD2, DRD3, DRD4, DRD5, CNR1
25alzheimer's disease29.9DRD2, DRD3, DRD4, OPRK1, OPRD1, OPRM1
26dependent personality disorder10.6
27alexithymia10.3
28mental depression10.1
29sleep disorder10.1
30restless legs syndrome10.0DRD2
31neuroblastoma10.0OPRM1
32hypertension10.0SLC6A4
33myoclonus-dystonia10.0DRD2
34premature ejaculation10.0SLC6A4
35fibromyalgia10.0SLC6A4
36obsessive-compulsive personality disorder10.0SLC6A4
37alcoholic psychosis10.0SLC6A4
38delusional disorder10.0DRD4, DRD2
39multiple system atrophy10.0DRD2, SLC6A3
40narcolepsy10.0DRD2
41cannabis dependence10.0CNR1
42essential tremor10.0DRD3, SLC6A3
43endogenous depression10.0DRD3, SLC6A4
44social phobia10.0DRD2, SLC6A4
45striatonigral degeneration10.0SLC6A3, DRD2
46focal dystonia10.0DRD5, DRD2
47seasonal affective disorder10.0TPH1, SLC6A4, DRD4
48wilson disease10.0SLC6A3, DRD2
49movement disease10.0SLC6A3, DRD3, DRD2
50anorexia nervosa10.0DRD4, CNR1, TPH1, SLC6A4

Graphical network of the top 20 diseases related to Substance Dependence:



Diseases related to substance dependence

Clinical Features for Substance Dependence

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Drugs & Therapeutics for Substance Dependence

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Substance Dependence

Drug clinical trials:

Search ClinicalTrials for Substance Dependence

Search NIH Clinical Center for Substance Dependence

Search CenterWatch for Substance Dependence

Genetic Tests for Substance Dependence

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Anatomical Context for Substance Dependence

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32MalaCards
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MalaCards organs/tissues related to Substance Dependence:

32
Testes, Brain, Lung, Bone marrow, Prostate, Skin, Breast, Colon, Smooth muscle, Whole blood, Bone, Eye, Endothelial

Animal Models for Substance Dependence or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Substance Dependence:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.9DRD2, CNR1, SLC6A3, ADH7
2MP:00053759.9DRD3, OPRM1, CNR1, TPH1, DRD2
3MP:00053799.2HTR1B, DRD2, DRD5, OPRK1, OPRM1, PICK1
4MP:00107719.1DRD2, OPRK1, OPRD1, OPRM1, CHRNB4, CNR1
5MP:00053768.9OPRM1, OPRD1, DRD4, DRD3, DRD2, CHRNB4
6MP:00053788.8HTR1B, DRD2, DRD3, OPRM1, CHRNB4, CNR1
7MP:00036318.8DRD2, DRD3, DRD4, DRD5, OPRD1, OPRM1
8MP:00053868.4TPH1, HTR1B, DRD2, DRD3, DRD4, OPRK1

Publications for Substance Dependence

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50PubMed
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Articles related to Substance Dependence:

(show top 50)    (show all 382)
idTitleAuthorsYear
1
Impact of Dual Disorders, Trauma, and Social Support on Quality of Life Among Women in Treatment for Substance Dependence. (23543844)
2013
2
A family history of substance dependence obscures the group differences in brain function associated with HIV-1 and ART. (22749564)
2013
3
Adjunctive Methylphenidate in the Treatment of Bulimia Nervosa Co-occurring with Bipolar Disorder and Substance Dependence. (23556140)
2013
4
Prefrontal white matter impairment in substance users depends upon the catechol-o-methyl transferase (COMT) val158met polymorphism. (23219927)
2013
5
The Brief Self-Control Scale Predicts Jail Inmates' Recidivism, Substance Dependence, and Post-Release Adjustment. (24345712)
2013
6
Integrated exposure-based therapy for co-occurring posttraumatic stress disorder and substance dependence: a randomized controlled trial. (22893166)
2012
7
Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses. (22591552)
2012
8
Mark Barrett on Mukta Sharma and Anindya Chatterjee's "Failure of substance use interventions: perspectives from Asia". Substance dependence treatment interventions: why we continue to fail people who use drugs in Asia. (23186492)
2012
9
Negative reinforcement learning is affected in substance dependence. (22079143)
2012
10
Disparities in safe sex counseling & behavior among individuals with substance dependence: a cross-sectional study. (23276300)
2012
11
Mediational relations between 12-Step attendance, depression and substance use in patients with comorbid substance dependence and major depression. (22578037)
2012
12
The translation of substance dependence criteria to food-related behaviors: different views and interpretations. (22740835)
2012
13
Reasons for help-seeking and associated fears in subjects with substance dependence. (23162192)
2012
14
Predictors of retention in the 'voluntary' and 'quasi-compulsory' treatment of substance dependence in europe. (21228594)
2011
15
Non-suicidal self-injury by intravenous application of nicotine in a patient with borderline personality disorder resulting in substance dependence. (21306599)
2011
16
Distinguishing general and specific personality disorder features and implications for substance dependence comorbidity. (21604829)
2011
17
Co-occurring Psychiatric and Substance Dependence Disorders as Predictors of Parolee Time to Rearrest. (22582021)
2011
18
Predictors of suicide-related hospitalization among U.S. veterans receiving treatment for comorbid depression and substance dependence: who is the riskiest of the risky? (21815915)
2011
19
Does comorbid substance use disorder exacerbate borderline personality features? A comparison of borderline personality disorder individuals with vs. without current substance dependence. (21116439)
2010
20
Deliberate self-harm in substance-dependent patients and relationship with alexithymia and personality disorders: a case-control study. (21122286)
2010
21
Are inmates' subjective sleep problems associated with borderline personality, psychopathy, and antisocial personality independent of depression and substance dependence? (20198127)
2010
22
A "community-friendly" version of integrated group therapy for patients with bipolar disorder and substance dependence: a randomized controlled trial. (19573999)
2009
23
Perceived peer delinquency and the genetic predisposition for substance dependence vulnerability. (19008053)
2009
24
Subtypes of major depression in substance dependence. (19681804)
2009
25
Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test. (18801187)
2008
26
The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. (17622222)
2008
27
ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects. (17918242)
2008
28
Comorbid disorders in patients with bipolar disorder and concomitant substance dependence. (17291591)
2007
29
A dimensional option for the diagnosis of substance dependence in DSM-V. (17623392)
2007
30
A randomized trial of integrated group therapy versus group drug counseling for patients with bipolar disorder and substance dependence. (17202550)
2007
31
Multiple substance dependence and course of alcoholism among Alaska native men and women. (16603457)
2006
32
The roles of familial alcoholism and adolescent family harmony in young adults' substance dependence disorders: mediated and moderated relations. (16737396)
2006
33
Emotion, decision-making and substance dependence: a somatic-marker model of addiction. (18615136)
2006
34
Co-occurring substance dependence and depression: practical implications and next questions. (16367973)
2005
35
Long-term stability of alcohol and other substance dependence diagnoses and habitual smoking: an evaluation after 5 years. (15997016)
2005
36
Quality of life and its correlates in patients with dual diagnosis of bipolar affective disorder and substance dependence. (15762860)
2005
37
Feasibility of a skills training approach to reduce substance dependence among individuals with schizophrenia. (12954948)
2003
38
Substance Dependence Severity Scale: reliability and validity for ICD-10 substance use disorders. (11456080)
2001
39
Effects of substance dependence on outcomes of patients in a randomized trial of two case management models. (10783183)
2000
40
Dr. Jekyll and Mr. Hyde: a primer on substance dependence. (10698849)
2000
41
Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence. (11092766)
2000
42
Concurrent and predictive validity of the Substance Dependence Severity Scale (SDSS). (10706977)
2000
43
Substance Dependence Severity Scale (SDSS): reliability and validity of a clinician-administered interview for DSM-IV substance use disorders. (10706976)
2000
44
Individual differences in electrodermal responsivity to predictable aversive stimuli and substance dependence. (10194966)
1999
45
Twin studies of adult psychiatric and substance dependence disorders: are they biased by differences in the environmental experiences of monozygotic and dizygotic twins in childhood and adolescence? (9626718)
1998
46
Relationship of cocaine and other substance dependence to well-being of high-risk psychiatric patients. (9661229)
1998
47
Quantitative electroencephalographic differences associated with alcohol, cocaine, heroin and dual-substance dependence. (9246556)
1997
48
The dynamic interaction between family and substance dependence: an international perspective. (7833902)
1994
49
Reliability of dual diagnosis. Substance dependence and psychiatric disorders. (1556565)
1992
50
Psychiatric diagnosis of patients with substance abuse problems: a comparison of two procedures, the DIS and the SADS-L. Alcoholism, drug abuse/dependence, anxiety disorders and antisocial personality disorder. (3560008)
1987

Genetic Variations for Substance Dependence

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Expression for genes affiliated with Substance Dependence

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Substance Dependence

Search GEO for disease gene expression data for Substance Dependence.

Pathways for genes affiliated with Substance Dependence

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53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB
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Pathways related to Substance Dependence according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.1CHRNA5, CHRNB4
210.0DRD2, DRD3, DRD4, DRD5
3
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10.0DRD5, DRD4, DRD3, DRD2
410.0DRD5, DRD4, DRD3, DRD2
5
Hide members
10.0ADH1A, ADH4, ADH7
6
Hide members
10.0ADH1A, ADH4, ADH7
7
Hide members
10.0ADH1A, ADH4, ADH7
8
Hide members
10.0ADH7, ADH4, ADH1A
9
Hide members
10.0ADH7, ADH4, ADH1A
10
Hide members
9.9DRD2, DRD3, DRD4, CHRNA5
11
Hide members
9.8PICK1, CHRNB4, CHRNA5, SLC6A3
12
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9.7HTR1B, DRD2, DRD3, DRD4, DRD5, SLC6A4
13
Hide members
9.2SLC6A4, HTR1B, DRD2, DRD3, DRD4, DRD5
14
Hide members
9.0HTR1B, DRD2, DRD3, DRD4, DRD5, OPRK1
15
Hide members
8.9HTR1B, DRD2, DRD3, DRD4, DRD5, OPRK1

Compounds for genes affiliated with Substance Dependence

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Substance Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 263)
idCompoundScoreTop Affiliating Genes
1(+)-butaclamol28 4411.3DRD2, DRD5, DRD4, DRD3
2piperazine44 1111.2DRD2, DRD3, SLC6A3, OPRM1, DRD4
3rotigotine44 28 1112.2DRD5, DRD3, DRD4, DRD2
4raclopride44 2811.2DRD4, DRD3, DRD2, SLC6A3
5methylphenidate44 49 1112.2DRD4, SLC6A3, SLC6A4, DRD5, DRD2
6ropinirole44 1111.2HTR1B, DRD2, DRD3, DRD4, DRD5
7lisuride28 44 1112.2DRD3, DRD5, HTR1B, DRD4, DRD2
8quinpirole44 2811.2DRD2, SLC6A3, CNR1, DRD4, DRD3
9pergolide28 44 1112.2HTR1B, DRD2, DRD3, DRD4, DRD5
10cabergoline28 44 1112.2HTR1B, DRD5, DRD4, DRD3, DRD2
11aripiprazole28 49 44 11 2414.2HTR1B, DRD2, DRD3, DRD4, DRD5
12roxindole28 4411.2HTR1B, DRD4, DRD3, DRD2
13pramipexole44 49 28 1113.1DRD2, HTR1B, SLC6A3, DRD5, DRD4, DRD3
14ziprasidone49 28 44 1113.1DRD5, DRD4, DRD2, DRD3, HTR1B
15bupropion44 49 11 2413.1CNR1, SLC6A3, DRD3, SLC6A4, DRD2
16spiperone28 4411.1DRD2, DRD3, DRD4, DRD5
17phencyclidine44 28 1112.1DRD2, DRD4, SLC6A3, OPRM1, OPRD1
18quetiapine44 49 28 11 2414.1SLC6A3, DRD5, DRD4, DRD3, DRD2, HTR1B
19terguride28 4411.1HTR1B, DRD4, DRD3, DRD2
20maoa4410.1HTR1B, SLC6A3, SLC6A4, TPH1, DRD2, DRD4
21paroxetine44 49 28 1113.1HTR1B, DRD3, DRD4, SLC6A3, SLC6A4, TPH1
22bromocriptine28 44 1112.1HTR1B, DRD2, DRD3, DRD4, SLC6A3, DRD5
23olanzapine49 44 28 11 2414.1DRD2, DRD3, DRD4, DRD5, SLC6A3, HTR1B
24risperidone28 44 49 59 11 2415.1DRD2, DRD4, SLC6A3, HTR1B, DRD3, SLC6A4
25Tapentadol1110.1OPRK1, SLC6A4, OPRM1, OPRD1
26fluoxetine49 44 28 1113.0SLC6A4, DRD2, CNR1, SLC6A3, HTR1B, TPH1
27apomorphine44 28 1112.0CNR1, DRD4, DRD5, DRD3, DRD2, HTR1B
28tramadol44 49 1112.0OPRD1, OPRK1, SLC6A4, OPRM1
29haloperidol44 28 2 49 1114.0OPRM1, DRD2, SLC6A4, SLC6A3, DRD5, DRD4
30nmda44 2811.0SLC6A3, PICK1, OPRK1, OPRD1, OPRM1, CNR1
31(-)-cyclazocine2810.0OPRK1, OPRD1, OPRM1
32amphetamine44 1111.0DRD2, SLC6A3, OPRK1, CNR1, DRD4, SLC6A4
336-hydroxydopamine449.9SLC6A3, OPRM1, DRD4, DRD3, DRD2
34baclofen44 1110.9CNR1, OPRM1, SLC6A3, OPRD1
35sulpiride44 28 1111.9SLC6A3, DRD4, DRD2, DRD3
36opiate449.9SLC6A3, DRD3, OPRM1, OPRK1, OPRD1, SLC6A4
37morphine44 49 28 1112.9OPRM1, OPRK1, CNR1, DRD2, OPRD1, SLC6A3
38methamphetamine44 49 1111.7PICK1, TPH1, SLC6A4, SLC6A3, OPRM1, OPRD1
395-hydroxytryptamine449.7SLC6A3, SLC6A4, TPH1, CNR1, OPRM1, OPRD1
40heroin44 49 1111.7OPRM1, CNR1, SLC6A3, SLC6A4, DRD3, OPRK1
41gaba449.6TPH1, SLC6A4, SLC6A3, CNR1, OPRM1, DRD4
42levodopa44 1110.6OPRK1, TPH1, SLC6A3, CNR1, OPRM1, DRD5
43cyclic amp44 2410.5OPRK1, DRD5, DRD4, DRD3, HTR1B, CNR1
44cocaine44 1110.5DRD2, HTR1B, DRD3, DRD4, SLC6A4, SLC6A3
45clozapine44 28 49 1112.5DRD3, OPRD1, NQO2, SLC6A3, SLC6A4, DRD4
46norepinephrine44 11 2411.4DRD3, DRD2, DRD4, DRD5, TPH1, SLC6A4
47glutamate449.3SLC6A3, TPH1, DRD3, CNR1, PICK1, OPRD1
48nicotine44 49 28 1112.2OPRD1, CNR1, TPH1, SLC6A4, SLC6A3, DRD2
49acetylcholine44 49 28 11 2413.2SLC6A3, CNR1, OPRM1, TPH1, OPRK1, OPRD1
50dopamine44 28 11 2412.1OPRK1, CNR1, SLC6A3, SLC6A4, TPH1, DRD5

GO Terms for genes affiliated with Substance Dependence

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16Gene Ontology
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Cellular components related to Substance Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:00589210.1CHRNA5, CHRNB4
2integral to plasma membraneGO:0058878.7SLC6A4, HTR1B, DRD2, DRD3, DRD4, DRD5
3plasma membraneGO:0058868.1OPRK1, DRD5, DRD4, DRD3, DRD2, HTR1B

Biological processes related to Substance Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of voltage-gated calcium channel activityGO:190138610.6DRD4, DRD2
2positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.6DRD4, DRD2
3negative regulation of dopamine receptor signaling pathwayGO:06016010.6DRD3, DRD2
4response to histamineGO:03477610.6DRD4, DRD3, DRD2
5regulation of dopamine uptake involved in synaptic transmissionGO:05158410.6DRD2, DRD3
6adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.5DRD2, DRD4, DRD3
7adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.5DRD5, OPRM1, DRD3
8dopamine metabolic processGO:04241710.5DRD4, DRD3, DRD2
9behavioral response to ethanolGO:04814910.5DRD2, DRD4, OPRM1
10behavioral response to cocaineGO:04814810.5DRD2, DRD3, DRD4
11regulation of cAMP metabolic processGO:03081410.5DRD3, DRD2
12negative regulation of protein secretionGO:05070910.5DRD4, DRD2, DRD3
13arachidonic acid secretionGO:05048210.5DRD3, DRD4, DRD2
14response to morphineGO:04327810.5CNR1, DRD3, DRD2
15regulation of dopamine secretionGO:01405910.5DRD2, DRD3, HTR1B
16prepulse inhibitionGO:06013410.5DRD3, DRD2, SLC6A3
17monoamine transportGO:01584410.5SLC6A3, PICK1, SLC6A4
18social behaviorGO:03517610.5DRD4, SLC6A4, DRD3
19G-protein coupled receptor internalizationGO:00203110.5DRD3, DRD2, HTR1B
20response to nicotineGO:03509410.5DRD2, CNR1, SLC6A3
21synaptic transmission, dopaminergicGO:00196310.5DRD4, DRD3, DRD2, DRD5
22adenohypophysis developmentGO:02198410.4SLC6A3, DRD2
23response to amphetamineGO:00197510.4DRD5, DRD4, DRD3, DRD2
24reduction of cytosolic calcium ion concentrationGO:05148110.4DRD2, OPRM1
25negative regulation of blood pressureGO:04577610.4DRD5, DRD2, DRD3, CNR1
26phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.4DRD5, DRD2
27negative regulation of adenylate cyclase activityGO:00719410.4OPRM1, DRD3, DRD2, DRD4
28behaviorGO:00761010.4OPRK1, CNR1, OPRM1
29alcohol metabolic processGO:00606610.4ADH4, ADH1A
30regulation of synaptic transmission, GABAergicGO:03222810.4CNR1, DRD2
31cellular calcium ion homeostasisGO:00687410.4DRD3, DRD2, DRD4, DRD5
32opioid receptor signaling pathwayGO:03800310.4OPRK1, OPRD1
33regulation of dopamine metabolic processGO:04205310.4DRD4, SLC6A3
34ethanol oxidationGO:00606910.4ADH1A, ADH7, ADH4
35behavioral response to nicotineGO:03509510.4CHRNB4, CHRNA5
36memoryGO:00761310.4NQO2, SLC6A4, CNR1
37sensory perception of painGO:01923310.4CNR1, OPRK1, OPRM1
38phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00720010.3OPRD1, OPRM1, OPRK1
39adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00719310.3OPRM1, OPRD1, OPRK1
40G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.3OPRM1, OPRD1, CNR1, HTR1B
41negative regulation of synaptic transmission, glutamatergicGO:05196710.3HTR1B, DRD2
42sensory perceptionGO:00760010.2OPRK1, OPRM1
43response to ethanolGO:04547110.2CNR1, SLC6A3, ADH7, DRD3, HTR1B
44negative regulation of cAMP biosynthetic processGO:03081810.2DRD4, HTR1B
45response to cocaineGO:04222010.2CNR1, SLC6A3, DRD5, DRD3, DRD2, HTR1B
46regulation of behaviorGO:05079510.1HTR1B, OPRM1
47locomotory behaviorGO:00762610.1CHRNB4, SLC6A3, DRD2, OPRM1, OPRK1, DRD3
48response to drugGO:04249310.0SLC6A4, DRD2, DRD3, SLC6A3
49response to iron ionGO:0100399.9DRD2, SLC6A3
50synaptic transmissionGO:0072689.8PICK1, OPRK1, CHRNB4, CHRNA5, SLC6A3, DRD5

Molecular functions related to Substance Dependence according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activityGO:00495210.4DRD5, DRD4
2dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.3DRD2, DRD3, DRD4
3monoamine transmembrane transporter activityGO:00850410.3SLC6A4, SLC6A3
4ligand-gated ion channel activityGO:01527610.2CHRNA5, CHRNB4
5retinol bindingGO:01984110.2ADH4, ADH7
6alcohol dehydrogenase activity, zinc-dependentGO:00402410.2ADH7, ADH4, ADH1A
7alcohol dehydrogenase (NAD) activityGO:00402210.2ADH1A, ADH4, ADH7
8dopamine bindingGO:03524010.1SLC6A3, DRD5, DRD4, DRD3, DRD2
9acetylcholine-activated cation-selective channel activityGO:00488910.1CHRNA5, CHRNB4
10acetylcholine receptor activityGO:01546410.0CHRNA5, CHRNB4
11drug bindingGO:0081449.9HTR1B, DRD2, DRD3, DRD4, CNR1, SLC6A3
12retinol dehydrogenase activityGO:0047459.9ADH7, ADH4

Products for genes affiliated with Substance Dependence

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Substance Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet