MCID: SBS002
MIFTS: 22

Substernal Goiter malady

Summaries for Substernal Goiter

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32MalaCards
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MalaCards: Substernal Goiter, also known as retrosternal thyroid goiter, is related to goiter and mediastinitis. An important gene associated with Substernal Goiter is CASK (calcium/calmodulin-dependent serine protein kinase (MAGUK family)). Affiliated tissues include thyroid, bone and testes.

Aliases & Classifications for Substernal Goiter

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

substernal goiter 8 10 60
retrosternal thyroid goiter 8


External Ids:

Disease Ontology8 DOID:13200
SNOMED-CT56 66392007, 190234009
MeSH34 D006045

Related Diseases for Substernal Goiter

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17GeneCards, 18GeneDecks
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Diseases related to Substernal Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 20)
idRelated DiseaseScoreTop Affiliating Genes
1goiter11.1
2mediastinitis10.4
3coronary artery disease10.3
4thyroiditis10.3
5tracheal disease10.3
6parathyroid carcinoma10.2
7tracheal stenosis10.2
8coronary aneurysm10.2
9multinodular goiter10.2
10ischemic neuropathy10.2
11ischemic optic neuropathy10.2
12aneurysm disease10.2
13aortic aneurysm10.2
14aortic disease10.2
15esophagitis10.2
16laryngitis10.2
17neuropathy10.2
18pulmonary emphysema10.2
19respiratory failure10.2
20thyrotoxicosis10.2

Graphical network of diseases related to Substernal Goiter:



Diseases related to substernal goiter

Clinical Features for Substernal Goiter

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Drugs & Therapeutics for Substernal Goiter

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Substernal Goiter

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Anatomical Context for Substernal Goiter

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32MalaCards
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MalaCards organs/tissues related to Substernal Goiter:

32
Thyroid, Bone, Testes, Trachea

Animal Models for Substernal Goiter or affiliated genes

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Publications for Substernal Goiter

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50PubMed
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Articles related to Substernal Goiter:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Successful management of trachea stenosis with massive substernal goiter via thacheobronchial stent. (24228633)
2013
2
Chylothorax associated with substernal goiter treated with transcervical thyroidectomy. (21476890)
2011
3
Single-stage operation for giant substernal goiter with severe coronary artery disease. (21881378)
2011
4
Acute respiratory failure caused by neglected giant substernal nontoxic goiter. (21655873)
2011
5
Morbidity and mortality of thyroidectomy for substernal goiter. (19827121)
2010
6
Image in endocrinology. Pemberton's sign in patient with substernal goiter. (20823469)
2010
7
Management of the substernal goiter: a team approach. (20830956)
2010
8
Clinical images. Solitary fibrous tumor of the perithyroidal soft tissue mimicking substernal goiter. (20609717)
2010
9
Substernal goiter: what is in a definition? (20109623)
2010
10
Superior vena cava syndrome and substernal goiter. (20151836)
2010
11
A critical analysis of 33 patients with substernal goiter surgically treated by neck incision. (19575100)
2009
12
Evidence-based surgical management of substernal goiter. (18266028)
2008
13
Solitary intrathyroidal metastasis of renal clear cell carcinoma in a toxic substernal multinodular goiter. (19014412)
2008
14
Diagnosis and management of substernal goiter at the University of Crete. (18239864)
2008
15
Extended tracheal stenosis secondary to a massive substernal goiter. (17956165)
2007
16
Thyroidectomy for substernal goiter via a mediastinoscopic approach. (16999061)
2006
17
Substernal goiter: an unusual cause of respiratory failure after coronary artery bypass grafting. (16107122)
2005
18
Management of an ascending aortic aneurysm with coronary artery disease and tracheal compression from a substernal goiter. (15725145)
2005
19
Thyroid abscess associated with a substernal goiter. Case report. (12813398)
2003
20
Visual vignette. Mediastinal mass due to substernal goiter. (12134778)
2002
21
Detection of a large substernal goiter during Tc-99m tetrofosmin cardiac SPECT imaging. (11391314)
2001
22
Operative management of substernal goiter: analysis of 52 patients. (12056465)
2001
23
Calcified substernal goiter seen on bone scan. (10983765)
2000
24
Bilateral recurrent nerve paralysis associated with multinodular substernal goiter: a case report. (10231217)
1999
25
Substernal goiter: clinical experience of 72 cases. (10335714)
1999
26
Use of a Foley catheter in the removal of a substernal goiter. (9817262)
1998
27
Management of substernal goiter. (9818814)
1998
28
Use of a Foley catheter in the removal of a substernal goiter. (9515535)
1998
29
Lymphatic compromise associated with substernal goiter. (9809698)
1998
30
Giant mediastinal parathyroid cyst masquerading as a substernal goiter. (9121802)
1997
31
Recurrent substernal nodular goiter: incidence and management. (8957497)
1996
32
Substernal goiter. (7475073)
1995
33
Superior vena cava syndrome due to a substernal nontoxic goiter. (8004873)
1994
34
Gastric pull-through imitating substernal goiter. (8062480)
1994
35
A case report of substernal goiter. (8014069)
1993
36
A large substernal goiter as a cause of a pulmonary perfusion defect. (1963388)
1990
37
Substernal goiter versus intrathoracic aberrant thyroid: a critical difference. (3196104)
1988
38
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 24-1987. A 56-year-old man with a substernal goiter, multiple cutaneous and mucosal lesions, and a positive stool test for occult blood. (3587282)
1987
39
Substernal goiter. Analysis of 80 patients from Massachusetts General Hospital. (3970328)
1985
40
Substernal goiter. (3885887)
1985
41
Sequestered substernal goiter. (6625801)
1983
42
Multinodular goiter with substernal component causing superior vena cava obstruction. (869733)
1977
43
Substernal goiter with superior vena caval obstruction. (1129707)
1975
44
Airway obstruction in substernal goiter. Clinical and therapeutic implications. (4777540)
1973
45
Substernal goiter associated with recurrent syncope and stroke. (4502375)
1972
46
A consideration of the proper surgical approach for substernal goiter. (14408062)
1960
47
Differential diagnosis, pathology, and treatment of substernal goiter. (13398297)
1957
48
CLINICO-PATHOLOGIC conference; substernal goiter, thyrotoxicosis, tracheal compression and pulmonary disease. (13207153)
1954
49
A case of substernal goiter with preoperative symptoms of parathyroid tetany. (15399001)
1950
50
Substernal goiter and pulmonary emphysema. (18120860)
1949

Genetic Variations for Substernal Goiter

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Expression for genes affiliated with Substernal Goiter

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Substernal Goiter

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Pathways for genes affiliated with Substernal Goiter

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Compounds for genes affiliated with Substernal Goiter

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GO Terms for genes affiliated with Substernal Goiter

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Products for genes affiliated with Substernal Goiter

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  • Antibodies
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Sources for Substernal Goiter

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet