MCID: SBS002
MIFTS: 25

Substernal Goiter

Categories: Endocrine diseases

Aliases & Classifications for Substernal Goiter

MalaCards integrated aliases for Substernal Goiter:

Name: Substernal Goiter 12 14 69
Retrosternal Thyroid Goiter 12
Goiter, Substernal 41

Classifications:



External Ids:

Disease Ontology 12 DOID:13200
MeSH 41 D006045
SNOMED-CT 64 190234009 66392007
UMLS 69 C0018024

Summaries for Substernal Goiter

MalaCards based summary : Substernal Goiter, also known as retrosternal thyroid goiter, is related to goiter and laryngitis. An important gene associated with Substernal Goiter is NOTCH1 (Notch 1), and among its related pathways/superpathways is Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include thyroid, trachea and testes.

Related Diseases for Substernal Goiter

Diseases related to Substernal Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 goiter 10.9
2 laryngitis 10.1
3 mediastinitis 10.1
4 subclavian steal syndrome 10.1 KANTR NOTCH1
5 petroclival meningioma 10.1 KANTR NOTCH1
6 brachial plexus neuritis 10.1 KANTR NOTCH1
7 arteries, anomalies of 10.1
8 coronary artery anomaly 10.1
9 thyroiditis 10.1
10 optic disk drusen 10.1 KANTR NOTCH1
11 sciatic neuropathy 10.0 KANTR NOTCH1
12 anterior cranial fossa meningioma 10.0 F7 KANTR
13 visual agnosia 10.0 F7 KANTR
14 dystonia 1, torsion, autosomal dominant 10.0 KANTR NOTCH1
15 thyroid crisis 10.0 KANTR TG
16 radiation cystitis 10.0 F7 KANTR
17 carotid artery dissection 9.9 KANTR NOTCH1
18 apnea, obstructive sleep 9.9
19 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 9.9
20 hemangiopericytoma, malignant 9.9
21 graves disease 1 9.9
22 ischemic optic neuropathy 9.9
23 pulmonary emphysema 9.9
24 sleep apnea 9.9
25 thrombosis 9.9
26 mucositis 9.9
27 respiratory failure 9.9
28 esophagitis 9.9
29 graves' disease 9.9
30 tracheal stenosis 9.9
31 aortic aneurysm 9.9
32 neuropathy 9.9
33 aneurysm 9.9
34 syncope 9.9
35 hypertropia 9.9 KANTR TG
36 salpingitis isthmica nodosa 9.9 CD79A KANTR
37 cicatricial entropion 9.8 CD79A KANTR
38 cerebral arteritis 9.8 CD79A KANTR
39 geniculate herpes zoster 9.8 CD79A KANTR
40 tabes dorsalis 9.8 CD79A KANTR
41 postsurgical hypothyroidism 9.8 CD79A TG
42 pulmonary hemosiderosis 9.7 CD79A F7
43 amyloid tumor 9.7 CD79A TG
44 chronic salpingitis 9.6 CD79A KANTR
45 hypersensitivity reaction disease 9.5 CD79A TG
46 immune system disease 9.4 CD79A TG
47 celiac disease 1 9.3 CD79A TG

Graphical network of the top 20 diseases related to Substernal Goiter:



Diseases related to Substernal Goiter

Symptoms & Phenotypes for Substernal Goiter

Drugs & Therapeutics for Substernal Goiter

Search Clinical Trials , NIH Clinical Center for Substernal Goiter

Cochrane evidence based reviews: goiter, substernal

Genetic Tests for Substernal Goiter

Anatomical Context for Substernal Goiter

MalaCards organs/tissues related to Substernal Goiter:

38
Thyroid, Trachea, Testes, Bone

Publications for Substernal Goiter

Articles related to Substernal Goiter:

(show top 50) (show all 79)
# Title Authors Year
1
Morbidity of total thyroidectomy for substernal goiter: A series of 70 patients. ( 28602544 )
2017
2
Patient-tailored management of an asymptomatic massive substernal goiter presenting as brachiocephalic vein occlusion. Report of a case and review of sternotomy indications. ( 28095343 )
2017
3
Chylothorax Associated with Substernal Goiter in Graves' Disease Treated with Radioactive Iodine. ( 28835765 )
2017
4
Substernal goiter and laryngopharyngeal reflux. ( 28658344 )
2017
5
Preoperative risk factors in total thyroidectomy of substernal goiter. ( 27932888 )
2016
6
Surgical treatment of substernal goiter: An analysis of 44 cases. ( 26995097 )
2016
7
Strategies of laparoscopic thyroidectomy for treatment of substernal goiter via areola approach. ( 27005286 )
2016
8
Substernal goiter: Experience with 50A cases. ( 26520480 )
2015
9
Sternotomy for substernal goiter: retrospective study of 52 operations. ( 25691265 )
2015
10
Harmonic focus in thyroidectomy for substernal goiter. ( 25752670 )
2015
11
Substernal goiter: when is a sternotomy required? ( 25976851 )
2015
12
eComment. Substernal goiter. Beware of the thyroidea ima artery. ( 24944323 )
2014
13
Transient palsy of recurrent laryngeal nerve postresection of giant substernal goiter. ( 25798363 )
2014
14
Substernal Goiter: When is a Sternotomy Required? ( 25058777 )
2014
15
Recurrent laryngeal nerve palsy and substernal goiter. An Italian multicenter study. ( 24880605 )
2014
16
Obstructive sleep apnea caused by substernal goiter presenting as nonarteritic ischemic optic neuropathy. ( 22899396 )
2013
17
Successful management of trachea stenosis with massive substernal goiter via thacheobronchial stent. ( 24228633 )
2013
18
Chylothorax associated with substernal goiter treated with transcervical thyroidectomy. ( 21476890 )
2011
19
Single-stage operation for giant substernal goiter with severe coronary artery disease. ( 21881378 )
2011
20
CT cross-sectional imaging classification system for substernal goiter based on risk factors for an extracervical surgical approach. ( 20737483 )
2011
21
Incidental detection of internal jugular vein thrombosis secondary to undiagnosed benign substernal goiter. ( 20814560 )
2010
22
Clinical images. Solitary fibrous tumor of the perithyroidal soft tissue mimicking substernal goiter. ( 20609717 )
2010
23
Superior vena cava syndrome and substernal goiter. ( 20151836 )
2010
24
Image in endocrinology. Pemberton's sign in patient with substernal goiter. ( 20823469 )
2010
25
Morbidity and mortality of thyroidectomy for substernal goiter. ( 19827121 )
2010
26
Management of the substernal goiter: a team approach. ( 20830956 )
2010
27
Substernal goiter: what is in a definition? ( 20109623 )
2010
28
A critical analysis of 33 patients with substernal goiter surgically treated by neck incision. ( 19575100 )
2009
29
Diagnosis and management of substernal goiter at the University of Crete. ( 18239864 )
2008
30
Surgical treatment of substernal goiter: an analysis of 59 patients. ( 18516529 )
2008
31
Evidence-based surgical management of substernal goiter. ( 18266028 )
2008
32
Extended tracheal stenosis secondary to a massive substernal goiter. ( 17956165 )
2007
33
Thyroidectomy for substernal goiter via a mediastinoscopic approach. ( 16999061 )
2006
34
VATS with a supraclavicular window for huge substernal goiter: an alternative technique for preventing recurrent laryngeal nerve injury. ( 16037869 )
2005
35
Substernal goiter: an unusual cause of respiratory failure after coronary artery bypass grafting. ( 16107122 )
2005
36
Management of an ascending aortic aneurysm with coronary artery disease and tracheal compression from a substernal goiter. ( 15725145 )
2005
37
Predictors of airway complications after thyroidectomy for substernal goiter. ( 15197094 )
2004
38
Novel technique for control of mediastinal bleeding during thyroidectomy for substernal goiter. ( 12742217 )
2003
39
Giant substernal goiter with chylothorax. ( 12878569 )
2003
40
Thyroid abscess associated with a substernal goiter. Case report. ( 12813398 )
2003
41
Visual vignette. Mediastinal mass due to substernal goiter. ( 12134778 )
2002
42
Operative management of substernal goiter: analysis of 52 patients. ( 12056465 )
2001
43
Detection of a large substernal goiter during Tc-99m tetrofosmin cardiac SPECT imaging. ( 11391314 )
2001
44
Calcified substernal goiter seen on bone scan. ( 10983765 )
2000
45
Surgical management of substernal goiter. ( 11155771 )
2000
46
Surgical treatment of substernal goiter. ( 11324994 )
2000
47
Substernal goiter: clinical experience of 72 cases. ( 10335714 )
1999
48
Bilateral recurrent nerve paralysis associated with multinodular substernal goiter: a case report. ( 10231217 )
1999
49
Management of substernal goiter. ( 9818814 )
1998
50
Use of a Foley catheter in the removal of a substernal goiter. ( 9817262 )
1998

Variations for Substernal Goiter

Expression for Substernal Goiter

Search GEO for disease gene expression data for Substernal Goiter.

Pathways for Substernal Goiter

Pathways related to Substernal Goiter according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.69 CD79A NOTCH1

GO Terms for Substernal Goiter

Biological processes related to Substernal Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 8.96 F7 NOTCH1
2 animal organ regeneration GO:0031100 8.62 F7 NOTCH1

Sources for Substernal Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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