MCID: SBS002
MIFTS: 21

Substernal Goiter malady

Summaries for Substernal Goiter

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Substernal Goiter, also known as retrosternal thyroid goiter, is related to coronary artery disease, and tracheal disease. An important gene associated with Substernal Goiter is CASK (calcium/calmodulin-dependent serine protein kinase (MAGUK family)). Affiliated tissues include thyroid and trachea.

Aliases & Classifications for Substernal Goiter

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 35MeSH, 57SNOMED-CT
See all sources

Aliases & Descriptions:

substernal goiter 8 10 61
retrosternal thyroid goiter 8


External Ids:

Disease Ontology8 DOID:13200
SNOMED-CT57 66392007, 190234009
MeSH35 D006045

Related Diseases for Substernal Goiter

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Substernal Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 17)
idRelated DiseaseScoreTop Affiliating Genes
1coronary artery disease,10.3
2tracheal disease10.3
3parathyroid carcinoma10.2
4tracheal stenosis10.2
5coronary aneurysm10.2
6multinodular goiter10.2
7ischemic neuropathy10.2
8ischemic optic neuropathy10.2
9aneurysm disease10.2
10aortic aneurysm10.2
11aortic disease10.2
12thyrotoxicosis10.2
13coronary artery aneurysm10.2
14superior vena cava syndrome10.2
15sleep apnea10.2
16syncope10.2
17solitary fibrous tumor10.2

Graphical network of diseases related to Substernal Goiter:



Diseases related to substernal goiter

Clinical Features for Substernal Goiter

Drugs & Therapeutics for Substernal Goiter

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Substernal Goiter

Drug clinical trials:

Search ClinicalTrials for Substernal Goiter

Search NIH Clinical Center for Substernal Goiter

Search CenterWatch for Substernal Goiter

Genetic Tests for Substernal Goiter

Anatomical Context for Substernal Goiter

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Substernal Goiter:

33
Thyroid, Trachea

Animal Models for Substernal Goiter or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Substernal Goiter

Sources:
51PubMed
See all sources

Articles related to Substernal Goiter:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Surgical treatment of large substernal thyroid goiter: analysis of 12 patients. (23936586)
2013
2
Obstructive sleep apnea caused by substernal goiter presenting as nonarteritic ischemic optic neuropathy. (22899396)
2013
3
Chylothorax associated with substernal goiter treated with transcervical thyroidectomy. (21476890)
2011
4
Acute respiratory failure caused by neglected giant substernal nontoxic goiter. (21655873)
2011
5
CT cross-sectional imaging classification system for substernal goiter based on risk factors for an extracervical surgical approach. (20737483)
2011
6
Morbidity and mortality of thyroidectomy for substernal goiter. (19827121)
2010
7
Image in endocrinology. Pemberton's sign in patient with substernal goiter. (20823469)
2010
8
Management of the substernal goiter: a team approach. (20830956)
2010
9
Clinical images. Solitary fibrous tumor of the perithyroidal soft tissue mimicking substernal goiter. (20609717)
2010
10
Substernal goiter: what is in a definition? (20109623)
2010
11
Superior vena cava syndrome and substernal goiter. (20151836)
2010
12
A critical analysis of 33 patients with substernal goiter surgically treated by neck incision. (19575100)
2009
13
Evidence-based surgical management of substernal goiter. (18266028)
2008
14
Solitary intrathyroidal metastasis of renal clear cell carcinoma in a toxic substernal multinodular goiter. (19014412)
2008
15
Extended tracheal stenosis secondary to a massive substernal goiter. (17956165)
2007
16
Thyroidectomy for substernal goiter via a mediastinoscopic approach. (16999061)
2006
17
Substernal goiter: an unusual cause of respiratory failure after coronary artery bypass grafting. (16107122)
2005
18
Management of an ascending aortic aneurysm with coronary artery disease and tracheal compression from a substernal goiter. (15725145)
2005
19
Predictors of airway complications after thyroidectomy for substernal goiter. (15197094)
2004
20
Novel technique for control of mediastinal bleeding during thyroidectomy for substernal goiter. (12742217)
2003
21
Giant substernal goiter with chylothorax. (12878569)
2003
22
Visual vignette. Mediastinal mass due to substernal goiter. (12134778)
2002
23
Detection of a large substernal goiter during Tc-99m tetrofosmin cardiac SPECT imaging. (11391314)
2001
24
Operative management of substernal goiter: analysis of 52 patients. (12056465)
2001
25
Calcified substernal goiter seen on bone scan. (10983765)
2000
26
Surgical management of substernal goiter. (11155771)
2000
27
Surgical treatment of substernal goiter. (11324994)
2000
28
Tracheal compression in a patient with substernal extension of a multinodular goiter. (10807067)
2000
29
Substernal goiter: clinical experience of 72 cases. (10335714)
1999
30
Management of substernal goiter. (9818814)
1998
31
Use of a Foley catheter in the removal of a substernal goiter. (9515535)
1998
32
Giant mediastinal parathyroid cyst masquerading as a substernal goiter. (9121802)
1997
33
Recurrent substernal nodular goiter: incidence and management. (8957497)
1996
34
Substernal goiter. (7475073)
1995
35
Surgical management of substernal goiter: analysis of 237 patients. (7661484)
1995
36
Gastric pull-through imitating substernal goiter. (8062480)
1994
37
A case report of substernal goiter. (8014069)
1993
38
Large parathyroid functioning carcinoma (1,200 g) presenting as a substernal goiter. (1560189)
1992
39
A large substernal goiter as a cause of a pulmonary perfusion defect. (1963388)
1990
40
Substernal goiter versus intrathoracic aberrant thyroid: a critical difference. (3196104)
1988
41
Substernal goiter. (3885887)
1985
42
Sequestered substernal goiter. (6679211)
1983
43
Multinodular goiter with substernal component causing superior vena cava obstruction. (869733)
1977
44
Esophageal tracer retention simulating substernal goiter. (845672)
1977
45
Substernal goiter with superior vena caval obstruction. (1129707)
1975
46
Airway obstruction in substernal goiter. Clinical and therapeutic implications. (4777540)
1973
47
Substernal goiter associated with recurrent syncope and stroke. (4502375)
1972
48
Substernal goiter. (5428874)
1970
49
CLINICO-PATHOLOGIC conference; substernal goiter, thyrotoxicosis, tracheal compression and pulmonary disease. (13207153)
1954
50
Substernal goiter and pulmonary emphysema. (18120860)
1949

Genetic Variations for Substernal Goiter

Expression for genes affiliated with Substernal Goiter

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Substernal Goiter

Search GEO for disease gene expression data for Substernal Goiter.

Pathways for genes affiliated with Substernal Goiter

Compounds for genes affiliated with Substernal Goiter

GO Terms for genes affiliated with Substernal Goiter

Products for genes affiliated with Substernal Goiter

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Substernal Goiter

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet