MCID: SBS002
MIFTS: 24

Substernal Goiter malady

Categories: Endocrine diseases

Aliases & Classifications for Substernal Goiter

Aliases & Descriptions for Substernal Goiter:

Name: Substernal Goiter 12 14 69
Retrosternal Thyroid Goiter 12
Goiter, Substernal 42

Classifications:



External Ids:

Disease Ontology 12 DOID:13200
MeSH 42 D006045
SNOMED-CT 64 190234009 66392007
UMLS 69 C0018024

Summaries for Substernal Goiter

MalaCards based summary : Substernal Goiter, also known as retrosternal thyroid goiter, is related to goiter and shipyard eye. An important gene associated with Substernal Goiter is NOTCH1 (Notch 1), and among its related pathways/superpathways is Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include thyroid, testes and bone.

Related Diseases for Substernal Goiter

Diseases related to Substernal Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
id Related Disease Score Top Affiliating Genes
1 goiter 10.8
2 shipyard eye 10.1 KANTR NOTCH1
3 pancreatic non-functioning delta cell tumor 10.1 KANTR NOTCH1
4 anal canal adenocarcinoma 10.1 KANTR NOTCH1
5 lethal congenital contracture syndrome 1 10.1 KANTR NOTCH1
6 maxillary sinus cancer 10.1 KANTR NOTCH1
7 acquired metabolic disease 10.1 F7 KANTR
8 seminoma 10.1 F7 KANTR
9 brain compression 10.1 KANTR NOTCH1
10 laryngitis 10.1
11 mediastinitis 10.1
12 iridocyclitis 10.0 KANTR NOTCH1
13 prostate small cell carcinoma 10.0 F7 KANTR
14 guillain-barre syndrome 10.0 KANTR TG
15 cervical alveolar soft part sarcoma 10.0 KANTR NOTCH1
16 lingual-facial-buccal dyskinesia 10.0 KANTR TG
17 gonococcal spondylitis 10.0 CD79A KANTR
18 pancreatic acinar cell adenocarcinoma 10.0 CD79A KANTR
19 spinal canal and spinal cord meningioma 10.0 CD79A KANTR
20 artery disease 10.0
21 thyroiditis 10.0
22 coronary artery disease 10.0
23 homocystinuria 10.0 CD79A KANTR
24 compensatory emphysema 9.9 CD79A KANTR
25 atheroembolism of kidney 9.9 CD79A TG
26 postinflammatory pulmonary fibrosis 9.9 CD79A F7
27 childhood vagina botryoid rhabdomyosarcoma 9.9 CD79A TG
28 acinic cell breast carcinoma 9.9 CD79A KANTR
29 uterine ligament serous adenocarcinoma 9.9 CD79A KANTR
30 substance-induced psychosis 9.8 CD79A KANTR
31 pulmonary emphysema 9.8
32 aneurysm 9.8
33 syncope 9.8
34 sleep apnea 9.8
35 obstructive sleep apnea 9.8
36 thrombosis 9.8
37 mucositis 9.8
38 respiratory failure 9.8
39 esophagitis 9.8
40 tracheal stenosis 9.8
41 aortic aneurysm 9.8
42 neuropathy 9.8
43 ischemic optic neuropathy 9.8
44 superior vena cava syndrome 9.8
45 membranoproliferative glomerulonephritis 9.8 CD79A TG
46 articulation disorder 9.8 CD79A TG
47 inflammatory bowel disease 3 9.7 CD79A TG
48 right bundle branch block 9.4 CD79A F7 KANTR NOTCH1 TG

Graphical network of the top 20 diseases related to Substernal Goiter:



Diseases related to Substernal Goiter

Symptoms & Phenotypes for Substernal Goiter

Drugs & Therapeutics for Substernal Goiter

Search Clinical Trials , NIH Clinical Center for Substernal Goiter

Cochrane evidence based reviews: goiter, substernal

Genetic Tests for Substernal Goiter

Anatomical Context for Substernal Goiter

MalaCards organs/tissues related to Substernal Goiter:

39
Thyroid, Testes, Bone, Trachea

Publications for Substernal Goiter

Articles related to Substernal Goiter:

(show top 50) (show all 76)
id Title Authors Year
1
Strategies of laparoscopic thyroidectomy for treatment of substernal goiter via areola approach. ( 27005286 )
2016
2
Erratum to: Strategies of laparoscopic thyroidectomy for treatment of substernal goiter via areola approach. ( 27387178 )
2016
3
Preoperative risk factors in total thyroidectomy of substernal goiter. ( 27932888 )
2016
4
Surgical treatment of substernal goiter: An analysis of 44 cases. ( 26995097 )
2016
5
Substernal goiter: when is a sternotomy required? ( 25976851 )
2015
6
Substernal goiter: Experience with 50A cases. ( 26520480 )
2015
7
Sternotomy for substernal goiter: retrospective study of 52 operations. ( 25691265 )
2015
8
Harmonic focus in thyroidectomy for substernal goiter. ( 25752670 )
2015
9
eComment. Substernal goiter. Beware of the thyroidea ima artery. ( 24944323 )
2014
10
Substernal Goiter: When is a Sternotomy Required? ( 25058777 )
2014
11
Recurrent laryngeal nerve palsy and substernal goiter. An Italian multicenter study. ( 24880605 )
2014
12
Transient palsy of recurrent laryngeal nerve postresection of giant substernal goiter. ( 25798363 )
2014
13
Obstructive sleep apnea caused by substernal goiter presenting as nonarteritic ischemic optic neuropathy. ( 22899396 )
2013
14
Successful management of trachea stenosis with massive substernal goiter via thacheobronchial stent. ( 24228633 )
2013
15
Single-stage operation for giant substernal goiter with severe coronary artery disease. ( 21881378 )
2011
16
CT cross-sectional imaging classification system for substernal goiter based on risk factors for an extracervical surgical approach. ( 20737483 )
2011
17
Chylothorax associated with substernal goiter treated with transcervical thyroidectomy. ( 21476890 )
2011
18
Incidental detection of internal jugular vein thrombosis secondary to undiagnosed benign substernal goiter. ( 20814560 )
2010
19
Management of the substernal goiter: a team approach. ( 20830956 )
2010
20
Clinical images. Solitary fibrous tumor of the perithyroidal soft tissue mimicking substernal goiter. ( 20609717 )
2010
21
Morbidity and mortality of thyroidectomy for substernal goiter. ( 19827121 )
2010
22
Image in endocrinology. Pemberton's sign in patient with substernal goiter. ( 20823469 )
2010
23
Superior vena cava syndrome and substernal goiter. ( 20151836 )
2010
24
Substernal goiter: what is in a definition? ( 20109623 )
2010
25
A critical analysis of 33 patients with substernal goiter surgically treated by neck incision. ( 19575100 )
2009
26
Evidence-based surgical management of substernal goiter. ( 18266028 )
2008
27
Diagnosis and management of substernal goiter at the University of Crete. ( 18239864 )
2008
28
Surgical treatment of substernal goiter: an analysis of 59 patients. ( 18516529 )
2008
29
Extended tracheal stenosis secondary to a massive substernal goiter. ( 17956165 )
2007
30
Thyroidectomy for substernal goiter via a mediastinoscopic approach. ( 16999061 )
2006
31
Management of an ascending aortic aneurysm with coronary artery disease and tracheal compression from a substernal goiter. ( 15725145 )
2005
32
VATS with a supraclavicular window for huge substernal goiter: an alternative technique for preventing recurrent laryngeal nerve injury. ( 16037869 )
2005
33
Substernal goiter: an unusual cause of respiratory failure after coronary artery bypass grafting. ( 16107122 )
2005
34
Predictors of airway complications after thyroidectomy for substernal goiter. ( 15197094 )
2004
35
Thyroid abscess associated with a substernal goiter. Case report. ( 12813398 )
2003
36
Novel technique for control of mediastinal bleeding during thyroidectomy for substernal goiter. ( 12742217 )
2003
37
Giant substernal goiter with chylothorax. ( 12878569 )
2003
38
Visual vignette. Mediastinal mass due to substernal goiter. ( 12134778 )
2002
39
Detection of a large substernal goiter during Tc-99m tetrofosmin cardiac SPECT imaging. ( 11391314 )
2001
40
Operative management of substernal goiter: analysis of 52 patients. ( 12056465 )
2001
41
Surgical treatment of substernal goiter. ( 11324994 )
2000
42
Surgical management of substernal goiter. ( 11155771 )
2000
43
Calcified substernal goiter seen on bone scan. ( 10983765 )
2000
44
Substernal goiter: clinical experience of 72 cases. ( 10335714 )
1999
45
Bilateral recurrent nerve paralysis associated with multinodular substernal goiter: a case report. ( 10231217 )
1999
46
Use of a Foley catheter in the removal of a substernal goiter. ( 9817262 )
1998
47
Lymphatic compromise associated with substernal goiter. ( 9809698 )
1998
48
Use of a Foley catheter in the removal of a substernal goiter. ( 9515535 )
1998
49
Management of substernal goiter. ( 9818814 )
1998
50
Giant mediastinal parathyroid cyst masquerading as a substernal goiter. ( 9121802 )
1997

Variations for Substernal Goiter

Expression for Substernal Goiter

Search GEO for disease gene expression data for Substernal Goiter.

Pathways for Substernal Goiter

Pathways related to Substernal Goiter according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.69 CD79A NOTCH1

GO Terms for Substernal Goiter

Biological processes related to Substernal Goiter according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 8.96 F7 NOTCH1
2 animal organ regeneration GO:0031100 8.62 F7 NOTCH1

Sources for Substernal Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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