MCID: SBS002
MIFTS: 22

Substernal Goiter malady

Summaries for Substernal Goiter

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32MalaCards
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MalaCards: Substernal Goiter, also known as retrosternal thyroid goiter, is related to goiter and mediastinitis. An important gene associated with Substernal Goiter is CASK (calcium/calmodulin-dependent serine protein kinase (MAGUK family)). Affiliated tissues include thyroid, testes and bone.

Aliases & Classifications for Substernal Goiter

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

substernal goiter 8 10 60
retrosternal thyroid goiter 8


External Ids:

Disease Ontology8 DOID:13200
SNOMED-CT56 66392007, 190234009
MeSH34 D006045

Related Diseases for Substernal Goiter

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17GeneCards, 18GeneDecks
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Diseases related to Substernal Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 20)
idRelated DiseaseScoreTop Affiliating Genes
1goiter11.1
2mediastinitis10.4
3coronary artery disease10.3
4thyroiditis10.3
5tracheal disease10.3
6parathyroid carcinoma10.2
7tracheal stenosis10.2
8coronary aneurysm10.2
9multinodular goiter10.2
10ischemic neuropathy10.2
11ischemic optic neuropathy10.2
12aneurysm disease10.2
13aortic aneurysm10.2
14aortic disease10.2
15esophagitis10.2
16laryngitis10.2
17neuropathy10.2
18pulmonary emphysema10.2
19respiratory failure10.2
20thyrotoxicosis10.2

Graphical network of diseases related to Substernal Goiter:



Diseases related to substernal goiter

Clinical Features for Substernal Goiter

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Drugs & Therapeutics for Substernal Goiter

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Substernal Goiter

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Anatomical Context for Substernal Goiter

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32MalaCards
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MalaCards organs/tissues related to Substernal Goiter:

32
Thyroid, Testes, Bone, Trachea

Animal Models for Substernal Goiter or affiliated genes

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Publications for Substernal Goiter

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50PubMed
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Articles related to Substernal Goiter:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Successful management of trachea stenosis with massive substernal goiter via thacheobronchial stent. (24228633)
2013
2
Surgical treatment of large substernal thyroid goiter: analysis of 12 patients. (23936586)
2013
3
Obstructive sleep apnea caused by substernal goiter presenting as nonarteritic ischemic optic neuropathy. (22899396)
2013
4
Chylothorax associated with substernal goiter treated with transcervical thyroidectomy. (21476890)
2011
5
Single-stage operation for giant substernal goiter with severe coronary artery disease. (21881378)
2011
6
Acute respiratory failure caused by neglected giant substernal nontoxic goiter. (21655873)
2011
7
CT cross-sectional imaging classification system for substernal goiter based on risk factors for an extracervical surgical approach. (20737483)
2011
8
Management of the substernal goiter: a team approach. (20830956)
2010
9
Incidental detection of internal jugular vein thrombosis secondary to undiagnosed benign substernal goiter. (20814560)
2010
10
Substernal goiter: what is in a definition? (20109623)
2010
11
A critical analysis of 33 patients with substernal goiter surgically treated by neck incision. (19575100)
2009
12
Solitary intrathyroidal metastasis of renal clear cell carcinoma in a toxic substernal multinodular goiter. (19014412)
2008
13
Surgical treatment of substernal goiter: an analysis of 59 patients. (18516529)
2008
14
Extended tracheal stenosis secondary to a massive substernal goiter. (17956165)
2007
15
Substernal goiter: an unusual cause of respiratory failure after coronary artery bypass grafting. (16107122)
2005
16
VATS with a supraclavicular window for huge substernal goiter: an alternative technique for preventing recurrent laryngeal nerve injury. (16037869)
2005
17
Management of an ascending aortic aneurysm with coronary artery disease and tracheal compression from a substernal goiter. (15725145)
2005
18
Predictors of airway complications after thyroidectomy for substernal goiter. (15197094)
2004
19
Novel technique for control of mediastinal bleeding during thyroidectomy for substernal goiter. (12742217)
2003
20
Giant substernal goiter with chylothorax. (12878569)
2003
21
Thyroid abscess associated with a substernal goiter. Case report. (12813398)
2003
22
Visual vignette. Mediastinal mass due to substernal goiter. (12134778)
2002
23
Detection of a large substernal goiter during Tc-99m tetrofosmin cardiac SPECT imaging. (11391314)
2001
24
Operative management of substernal goiter: analysis of 52 patients. (12056465)
2001
25
Calcified substernal goiter seen on bone scan. (10983765)
2000
26
Surgical management of substernal goiter. (11155771)
2000
27
Surgical treatment of substernal goiter. (11324994)
2000
28
Tracheal compression in a patient with substernal extension of a multinodular goiter. (10807067)
2000
29
Bilateral recurrent nerve paralysis associated with multinodular substernal goiter: a case report. (10231217)
1999
30
Substernal goiter: clinical experience of 72 cases. (10335714)
1999
31
Use of a Foley catheter in the removal of a substernal goiter. (9817262)
1998
32
Management of substernal goiter. (9818814)
1998
33
Giant mediastinal parathyroid cyst masquerading as a substernal goiter. (9121802)
1997
34
Surgical management of substernal goiter: analysis of 237 patients. (7661484)
1995
35
Gastric pull-through imitating substernal goiter. (8062480)
1994
36
Surgical management of substernal goiter. (7863290)
1994
37
Substernal goiter: a clinical review. (7872476)
1994
38
Large parathyroid functioning carcinoma (1,200 g) presenting as a substernal goiter. (1560189)
1992
39
Substernal goiter versus intrathoracic aberrant thyroid: a critical difference. (3196104)
1988
40
Surgery of substernal goiter. (3331229)
1987
41
Substernal goiter. Analysis of 80 patients from Massachusetts General Hospital. (3970328)
1985
42
Substernal goiter. (3885887)
1985
43
Sequestered substernal goiter. (6625801)
1983
44
Sequestered substernal goiter. (6679211)
1983
45
Esophageal tracer retention simulating substernal goiter. (845672)
1977
46
Substernal goiter associated with recurrent syncope and stroke. (4502375)
1972
47
Substernal goiter. (5428874)
1970
48
INTRATHORACIC AND SUBSTERNAL GOITER: SOME CONSIDERATION IN MANAGEMENT. (14079533)
1963
49
CLINICO-PATHOLOGIC conference; substernal goiter, thyrotoxicosis, tracheal compression and pulmonary disease. (13207153)
1954
50
A case of substernal goiter with preoperative symptoms of parathyroid tetany. (15399001)
1950

Genetic Variations for Substernal Goiter

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Expression for genes affiliated with Substernal Goiter

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Substernal Goiter

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Pathways for genes affiliated with Substernal Goiter

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Compounds for genes affiliated with Substernal Goiter

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GO Terms for genes affiliated with Substernal Goiter

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Products for genes affiliated with Substernal Goiter

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  • Antibodies
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  • Lysates
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Sources for Substernal Goiter

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet