MCID: SBS002
MIFTS: 24

Substernal Goiter malady

Category: Endocrine diseases

Aliases & Classifications for Substernal Goiter

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Aliases & Descriptions for Substernal Goiter:

Name: Substernal Goiter 11 13 68
Retrosternal Thyroid Goiter 11
 
Goiter, Substernal 39

Classifications:



External Ids:

Disease Ontology11 DOID:13200
SNOMED-CT62 190234009, 66392007
MeSH39 D006045

Summaries for Substernal Goiter

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MalaCards based summary: Substernal Goiter, also known as retrosternal thyroid goiter, is related to goiter and shipyard eye. An important gene associated with Substernal Goiter is NOTCH1 (Notch 1), and among its related pathways is Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include thyroid, trachea and testes.

Related Diseases for Substernal Goiter

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Diseases related to Substernal Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1goiter10.8
2shipyard eye10.1KANTR, NOTCH1
3pancreatic non-functioning delta cell tumor10.1KANTR, NOTCH1
4anal canal adenocarcinoma10.1KANTR, NOTCH1
5lethal congenital contracture syndrome 110.1KANTR, NOTCH1
6maxillary sinus cancer10.1KANTR, NOTCH1
7acquired metabolic disease10.1F7, KANTR
8seminoma10.1F7, KANTR
9brain compression10.1KANTR, NOTCH1
10laryngitis10.1
11mediastinitis10.1
12iridocyclitis10.0KANTR, NOTCH1
13prostate small cell carcinoma10.0F7, KANTR
14guillain-barre syndrome10.0KANTR, TG
15cervical alveolar soft part sarcoma10.0KANTR, NOTCH1
16lingual-facial-buccal dyskinesia10.0KANTR, TG
17gonococcal spondylitis10.0CD79A, KANTR
18pancreatic acinar cell adenocarcinoma10.0CD79A, KANTR
19spinal canal and spinal cord meningioma10.0CD79A, KANTR
20coronary artery disease10.0
21artery disease10.0
22thyroiditis10.0
23homocystinuria10.0CD79A, KANTR
24compensatory emphysema9.9CD79A, KANTR
25atheroembolism of kidney9.9CD79A, TG
26postinflammatory pulmonary fibrosis9.9CD79A, F7
27childhood vagina botryoid rhabdomyosarcoma9.9CD79A, TG
28acinic cell breast carcinoma9.9CD79A, KANTR
29uterine ligament serous adenocarcinoma9.9CD79A, KANTR
30substance-induced psychosis9.8CD79A, KANTR
31ischemic optic neuropathy9.8
32pulmonary emphysema9.8
33sleep apnea9.8
34obstructive sleep apnea9.8
35thrombosis9.8
36mucositis9.8
37respiratory failure9.8
38esophagitis9.8
39tracheal stenosis9.8
40aortic aneurysm9.8
41neuropathy9.8
42superior vena cava syndrome9.8
43aneurysm9.8
44syncope9.8
45membranoproliferative glomerulonephritis9.8CD79A, TG
46articulation disorder9.8CD79A, TG
47inflammatory bowel disease 39.7CD79A, TG
48right bundle branch block9.4CD79A, F7, KANTR, NOTCH1, TG

Graphical network of the top 20 diseases related to Substernal Goiter:



Diseases related to substernal goiter

Symptoms & Phenotypes for Substernal Goiter

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Drugs & Therapeutics for Substernal Goiter

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Substernal Goiter


Cochrane evidence based reviews: goiter, substernal

Genetic Tests for Substernal Goiter

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Anatomical Context for Substernal Goiter

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MalaCards organs/tissues related to Substernal Goiter:

36
Thyroid, Trachea, Testes, Bone

Publications for Substernal Goiter

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Articles related to Substernal Goiter:

(show top 50)    (show all 76)
idTitleAuthorsYear
1
Strategies of laparoscopic thyroidectomy for treatment of substernal goiter via areola approach. (27005286)
2016
2
Erratum to: Strategies of laparoscopic thyroidectomy for treatment of substernal goiter via areola approach. (27387178)
2016
3
Preoperative risk factors in total thyroidectomy of substernal goiter. (27932888)
2016
4
Surgical treatment of substernal goiter: An analysis of 44 cases. (26995097)
2016
5
Substernal goiter: when is a sternotomy required? (25976851)
2015
6
Substernal goiter: Experience with 50A cases. (26520480)
2015
7
Sternotomy for substernal goiter: retrospective study of 52 operations. (25691265)
2015
8
Harmonic focus in thyroidectomy for substernal goiter. (25752670)
2015
9
eComment. Substernal goiter. Beware of the thyroidea ima artery. (24944323)
2014
10
Substernal Goiter: When is a Sternotomy Required? (25058777)
2014
11
Recurrent laryngeal nerve palsy and substernal goiter. An Italian multicenter study. (24880605)
2014
12
Transient palsy of recurrent laryngeal nerve postresection of giant substernal goiter. (25798363)
2014
13
Obstructive sleep apnea caused by substernal goiter presenting as nonarteritic ischemic optic neuropathy. (22899396)
2013
14
Successful management of trachea stenosis with massive substernal goiter via thacheobronchial stent. (24228633)
2013
15
Single-stage operation for giant substernal goiter with severe coronary artery disease. (21881378)
2011
16
CT cross-sectional imaging classification system for substernal goiter based on risk factors for an extracervical surgical approach. (20737483)
2011
17
Chylothorax associated with substernal goiter treated with transcervical thyroidectomy. (21476890)
2011
18
Incidental detection of internal jugular vein thrombosis secondary to undiagnosed benign substernal goiter. (20814560)
2010
19
Management of the substernal goiter: a team approach. (20830956)
2010
20
Clinical images. Solitary fibrous tumor of the perithyroidal soft tissue mimicking substernal goiter. (20609717)
2010
21
Morbidity and mortality of thyroidectomy for substernal goiter. (19827121)
2010
22
Image in endocrinology. Pemberton's sign in patient with substernal goiter. (20823469)
2010
23
Superior vena cava syndrome and substernal goiter. (20151836)
2010
24
Substernal goiter: what is in a definition? (20109623)
2010
25
A critical analysis of 33 patients with substernal goiter surgically treated by neck incision. (19575100)
2009
26
Evidence-based surgical management of substernal goiter. (18266028)
2008
27
Diagnosis and management of substernal goiter at the University of Crete. (18239864)
2008
28
Surgical treatment of substernal goiter: an analysis of 59 patients. (18516529)
2008
29
Extended tracheal stenosis secondary to a massive substernal goiter. (17956165)
2007
30
Thyroidectomy for substernal goiter via a mediastinoscopic approach. (16999061)
2006
31
Management of an ascending aortic aneurysm with coronary artery disease and tracheal compression from a substernal goiter. (15725145)
2005
32
VATS with a supraclavicular window for huge substernal goiter: an alternative technique for preventing recurrent laryngeal nerve injury. (16037869)
2005
33
Substernal goiter: an unusual cause of respiratory failure after coronary artery bypass grafting. (16107122)
2005
34
Predictors of airway complications after thyroidectomy for substernal goiter. (15197094)
2004
35
Thyroid abscess associated with a substernal goiter. Case report. (12813398)
2003
36
Novel technique for control of mediastinal bleeding during thyroidectomy for substernal goiter. (12742217)
2003
37
Giant substernal goiter with chylothorax. (12878569)
2003
38
Visual vignette. Mediastinal mass due to substernal goiter. (12134778)
2002
39
Detection of a large substernal goiter during Tc-99m tetrofosmin cardiac SPECT imaging. (11391314)
2001
40
Operative management of substernal goiter: analysis of 52 patients. (12056465)
2001
41
Surgical treatment of substernal goiter. (11324994)
2000
42
Surgical management of substernal goiter. (11155771)
2000
43
Calcified substernal goiter seen on bone scan. (10983765)
2000
44
Substernal goiter: clinical experience of 72 cases. (10335714)
1999
45
Bilateral recurrent nerve paralysis associated with multinodular substernal goiter: a case report. (10231217)
1999
46
Use of a Foley catheter in the removal of a substernal goiter. (9817262)
1998
47
Lymphatic compromise associated with substernal goiter. (9809698)
1998
48
Use of a Foley catheter in the removal of a substernal goiter. (9515535)
1998
49
Management of substernal goiter. (9818814)
1998
50
Giant mediastinal parathyroid cyst masquerading as a substernal goiter. (9121802)
1997

Variations for Substernal Goiter

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Expression for genes affiliated with Substernal Goiter

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Search GEO for disease gene expression data for Substernal Goiter.

Pathways for genes affiliated with Substernal Goiter

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Pathways related to Substernal Goiter according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.2CD79A, NOTCH1

GO Terms for genes affiliated with Substernal Goiter

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Biological processes related to Substernal Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1animal organ regenerationGO:003110010.1F7, NOTCH1
2positive regulation of cell migrationGO:00303359.5F7, NOTCH1

Sources for Substernal Goiter

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet