MCID: SBS002
MIFTS: 24

Substernal Goiter malady

Category: Endocrine diseases

Aliases & Classifications for Substernal Goiter

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Aliases & Descriptions for Substernal Goiter:

Name: Substernal Goiter 11 13 66
Retrosternal Thyroid Goiter 11
 
Goiter, Substernal 37

Classifications:



External Ids:

Disease Ontology11 DOID:13200
SNOMED-CT60 190234009, 66392007
MeSH37 D006045

Summaries for Substernal Goiter

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MalaCards based summary: Substernal Goiter, also known as retrosternal thyroid goiter, is related to goiter and laryngitis. An important gene associated with Substernal Goiter is F7 (Coagulation Factor VII), and among its related pathways is Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include thyroid, trachea and testes.

Related Diseases for Substernal Goiter

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Diseases related to Substernal Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1goiter10.9
2laryngitis10.2
3mediastinitis10.2
4intra-abdominal lymph node mast cell malignancy10.2KANTR, NOTCH1
5diffuse alopecia areata10.2F7, KANTR
6central nervous system germinoma10.2F7, KANTR
7renal infectious disease10.2KANTR, NOTCH1
8abnormal threshold of rods10.1KANTR, NOTCH1
9lesion of sciatic nerve10.1KANTR, NOTCH1
10brachial plexus neuropathy10.1KANTR, NOTCH1
11coronary artery disease10.1
12artery disease10.1
13thyroiditis10.1
14urinary bladder small cell neuroendocrine carcinoma10.1F7, KANTR
15perinatal jaundice due to hepatocellular damage10.1KANTR, NOTCH1
16tibial collateral ligament bursitis10.0KANTR, NOTCH1
17ancylostomiasis10.0KANTR, TG
18olfactory neuroblastoma10.0KANTR, NOTCH1
19ischemic optic neuropathy10.0
20pulmonary emphysema10.0
21sleep apnea10.0
22obstructive sleep apnea10.0
23respiratory failure10.0
24esophagitis10.0
25tracheal stenosis10.0
26aortic aneurysm10.0
27neuropathy10.0
28superior vena cava syndrome10.0
29aneurysm10.0
30syncope10.0
31intrinsic asthma9.9KANTR, NOTCH1
32protein-deficiency anemia9.9CD79A, KANTR
33central nervous system germ cell tumor9.9KANTR, NOTCH1
34pyosalpinx9.9CD79A, KANTR
35heart disease9.9CD79A, KANTR
36pompholyx9.9CD79A, KANTR
37interstitial emphysema9.8CD79A, KANTR
38papilledema9.8CD79A, TG
39pulmonary alveolar proteinosis9.8CD79A, F7
40bone lymphoma9.7CD79A, TG
41salpingitis9.7CD79A, KANTR
42brachyolmia9.6NOTCH1, TG
43blood group incompatibility9.4CD79A, TG
44sarcoidosis 19.4CD79A, TG
45gemistocytic astrocytoma9.2CD79A, KANTR
46background diabetic retinopathy8.3CD79A, F7, KANTR, NOTCH1, TG

Graphical network of the top 20 diseases related to Substernal Goiter:



Diseases related to substernal goiter

Symptoms for Substernal Goiter

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Drugs & Therapeutics for Substernal Goiter

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Substernal Goiter


Cochrane evidence based reviews: goiter, substernal

Genetic Tests for Substernal Goiter

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Anatomical Context for Substernal Goiter

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MalaCards organs/tissues related to Substernal Goiter:

34
Thyroid, Trachea, Testes, Bone

Animal Models for Substernal Goiter or affiliated genes

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Publications for Substernal Goiter

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Articles related to Substernal Goiter:

(show top 50)    (show all 74)
idTitleAuthorsYear
1
Strategies of laparoscopic thyroidectomy for treatment of substernal goiter via areola approach. (27005286)
2016
2
Harmonic focus in thyroidectomy for substernal goiter. (25752670)
2015
3
Sternotomy for substernal goiter: retrospective study of 52 operations. (25691265)
2015
4
eComment. Substernal goiter. Beware of the thyroidea ima artery. (24944323)
2014
5
Substernal Goiter: When is a Sternotomy Required? (25058777)
2014
6
Obstructive sleep apnea caused by substernal goiter presenting as nonarteritic ischemic optic neuropathy. (22899396)
2013
7
Successful management of trachea stenosis with massive substernal goiter via thacheobronchial stent. (24228633)
2013
8
Chylothorax associated with substernal goiter treated with transcervical thyroidectomy. (21476890)
2011
9
CT cross-sectional imaging classification system for substernal goiter based on risk factors for an extracervical surgical approach. (20737483)
2011
10
Management of the substernal goiter: a team approach. (20830956)
2010
11
Incidental detection of internal jugular vein thrombosis secondary to undiagnosed benign substernal goiter. (20814560)
2010
12
Clinical images. Solitary fibrous tumor of the perithyroidal soft tissue mimicking substernal goiter. (20609717)
2010
13
Substernal goiter: what is in a definition? (20109623)
2010
14
Morbidity and mortality of thyroidectomy for substernal goiter. (19827121)
2010
15
A critical analysis of 33 patients with substernal goiter surgically treated by neck incision. (19575100)
2009
16
Evidence-based surgical management of substernal goiter. (18266028)
2008
17
Surgical treatment of substernal goiter: an analysis of 59 patients. (18516529)
2008
18
Diagnosis and management of substernal goiter at the University of Crete. (18239864)
2008
19
Thyroidectomy for substernal goiter via a mediastinoscopic approach. (16999061)
2006
20
Substernal goiter: an unusual cause of respiratory failure after coronary artery bypass grafting. (16107122)
2005
21
Management of an ascending aortic aneurysm with coronary artery disease and tracheal compression from a substernal goiter. (15725145)
2005
22
Predictors of airway complications after thyroidectomy for substernal goiter. (15197094)
2004
23
Giant substernal goiter with chylothorax. (12878569)
2003
24
Thyroid abscess associated with a substernal goiter. Case report. (12813398)
2003
25
Novel technique for control of mediastinal bleeding during thyroidectomy for substernal goiter. (12742217)
2003
26
Detection of a large substernal goiter during Tc-99m tetrofosmin cardiac SPECT imaging. (11391314)
2001
27
Surgical treatment of substernal goiter. (11324994)
2000
28
Calcified substernal goiter seen on bone scan. (10983765)
2000
29
Surgical management of substernal goiter. (11155771)
2000
30
Management of substernal goiter. (9818814)
1998
31
Lymphatic compromise associated with substernal goiter. (9809698)
1998
32
Use of a Foley catheter in the removal of a substernal goiter. (9817262)
1998
33
Giant mediastinal parathyroid cyst masquerading as a substernal goiter. (9121802)
1997
34
Substernal goiter. (7475073)
1995
35
Gastric pull-through imitating substernal goiter. (8062480)
1994
36
Substernal goiter: a clinical review. (7872476)
1994
37
Large parathyroid functioning carcinoma (1,200 g) presenting as a substernal goiter. (1560189)
1992
38
A large substernal goiter as a cause of a pulmonary perfusion defect. (1963388)
1990
39
Surgery of substernal goiter. (3331229)
1987
40
Substernal goiter. Analysis of 80 patients from Massachusetts General Hospital. (3970328)
1985
41
Sequestered substernal goiter. (6625801)
1983
42
Esophageal tracer retention simulating substernal goiter. (845672)
1977
43
Substernal goiter with superior vena caval obstruction. (1129707)
1975
44
Airway obstruction in substernal goiter. Clinical and therapeutic implications. (4777540)
1973
45
Substernal goiter. (5428874)
1970
46
INTRATHORACIC AND SUBSTERNAL GOITER: SOME CONSIDERATION IN MANAGEMENT. (14079533)
1963
47
A consideration of the proper surgical approach for substernal goiter. (14408062)
1960
48
Differential diagnosis, pathology, and treatment of substernal goiter. (13398297)
1957
49
CLINICO-PATHOLOGIC conference; substernal goiter, thyrotoxicosis, tracheal compression and pulmonary disease. (13207153)
1954
50
Substernal goiter and pulmonary emphysema. (18120860)
1949

Variations for Substernal Goiter

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Expression for genes affiliated with Substernal Goiter

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Search GEO for disease gene expression data for Substernal Goiter.

Pathways for genes affiliated with Substernal Goiter

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Pathways related to Substernal Goiter according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.1CD79A, NOTCH1

GO Terms for genes affiliated with Substernal Goiter

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Biological processes related to Substernal Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell migrationGO:00303359.5F7, NOTCH1
2animal organ regenerationGO:00311009.4F7, NOTCH1

Sources for Substernal Goiter

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet