MCID: SBS002
MIFTS: 27

Substernal Goiter malady

Endocrine diseases category

Aliases & Classifications for Substernal Goiter

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Aliases & Descriptions for Substernal Goiter:

Name: Substernal Goiter 10 65
Retrosternal Thyroid Goiter 10
 
Goiter, Substernal 36


Classifications:



External Ids:

Disease Ontology10 DOID:13200
SNOMED-CT59 190234009, 66392007
MeSH36 D006045

Summaries for Substernal Goiter

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MalaCards based summary: Substernal Goiter, also known as retrosternal thyroid goiter, is related to goiter and laryngitis. An important gene associated with Substernal Goiter is F7 (Coagulation Factor VII (Serum Prothrombin Conversion Accelerator)). Affiliated tissues include thyroid, trachea and testes, and related mouse phenotype homeostasis/metabolism.

Related Diseases for Substernal Goiter

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Diseases related to Substernal Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1goiter11.2
2laryngitis10.5
3mediastinitis10.5
4coronary artery disease10.4
5artery disease10.4
6thyroiditis10.4
7ischemic optic neuropathy10.2
8pulmonary emphysema10.2
9tracheal stenosis10.2
10obstructive sleep apnea10.2
11aortic aneurysm10.2
12esophagitis10.2
13neuropathy10.2
14respiratory failure10.2
15sleep apnea10.2
16superior vena cava syndrome10.2
17aneurysm10.2
18syncope10.2
19solitary fibrous tumor10.2
20alcoholic pancreatitis10.1KANTR, NOTCH1
21mixed astrocytoma-ependymoma-oligodendroglioma10.1KANTR, NOTCH1
22meckel's diverticulum cancer10.1KANTR, NOTCH1
23anterior scleritis10.1F7, KANTR
24common peroneal nerve lesion10.1KANTR, NOTCH1
25visual cortex disease10.1F7, KANTR
26tic disorder10.1KANTR, NOTCH1
27kidney rhabdoid cancer10.1KANTR, NOTCH1
28cascade stomach10.1KANTR, NOTCH1
29ariboflavinosis10.1F7, KANTR
30penis papillary carcinoma10.1KANTR, NOTCH1
31mononeuritis of upper limb and mononeuritis multiplex10.0KANTR, NOTCH1
32skull base neoplasm10.0KANTR, NOTCH1
33breast rhabdomyosarcoma10.0PTH, TG
34leukocyte disease10.0KANTR, NOTCH1
35pericholangitis10.0CD79A, KANTR
36pulmonary edema10.0CD79A, KANTR
37sclerosing keratitis10.0CD79A, KANTR
38posterior corneal pigmentation9.9CD79A, F7
39central sleep apnea9.9CD79A, KANTR
40paracoccidioidomycosis9.9CD79A, KANTR
41mucinous tubular and spindle renal cell carcinoma9.9CD79A, PTH
42typhoid fever9.9CD79A, PTH
43endocrine pancreas disease9.9PTH, TG
44ciliopathy9.8CD79A, KANTR
45rumination disorder9.8KANTR, PTH, TG
46celiac disease9.8CD79A, TG
47epidermolysis bullosa dystrophica9.7CD79A, PTH
48dyshormonogenic goiter9.7CD79A, PTH, TG
49urinary tract obstruction9.6CD79A, PTH
50malignant cardiac peripheral nerve sheath neoplasm9.2CD79A, F7, KANTR, NOTCH1, PTH, TG

Graphical network of the top 20 diseases related to Substernal Goiter:



Diseases related to substernal goiter

Symptoms for Substernal Goiter

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Drugs & Therapeutics for Substernal Goiter

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Substernal Goiter


Cochrane evidence based reviews: Goiter, Substernal

Genetic Tests for Substernal Goiter

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Anatomical Context for Substernal Goiter

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MalaCards organs/tissues related to Substernal Goiter:

33
Thyroid, Trachea, Testes, Bone

Animal Models for Substernal Goiter or affiliated genes

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MGI Mouse Phenotypes related to Substernal Goiter:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.6CD79A, F7, NOTCH1, PTH, TG

Publications for Substernal Goiter

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Articles related to Substernal Goiter:

(show top 50)    (show all 72)
idTitleAuthorsYear
1
Sternotomy for substernal goiter: retrospective study of 52 operations. (25691265)
2015
2
Harmonic focus in thyroidectomy for substernal goiter. (25752670)
2015
3
Substernal goiter: Experience with 50A cases. (26520480)
2015
4
Recurrent laryngeal nerve palsy and substernal goiter. An Italian multicenter study. (24880605)
2014
5
Successful management of trachea stenosis with massive substernal goiter via thacheobronchial stent. (24228633)
2013
6
Chylothorax associated with substernal goiter treated with transcervical thyroidectomy. (21476890)
2011
7
Single-stage operation for giant substernal goiter with severe coronary artery disease. (21881378)
2011
8
Morbidity and mortality of thyroidectomy for substernal goiter. (19827121)
2010
9
Image in endocrinology. Pemberton's sign in patient with substernal goiter. (20823469)
2010
10
Management of the substernal goiter: a team approach. (20830956)
2010
11
Incidental detection of internal jugular vein thrombosis secondary to undiagnosed benign substernal goiter. (20814560)
2010
12
A critical analysis of 33 patients with substernal goiter surgically treated by neck incision. (19575100)
2009
13
Evidence-based surgical management of substernal goiter. (18266028)
2008
14
Surgical treatment of substernal goiter: an analysis of 59 patients. (18516529)
2008
15
Extended tracheal stenosis secondary to a massive substernal goiter. (17956165)
2007
16
Thyroidectomy for substernal goiter via a mediastinoscopic approach. (16999061)
2006
17
Substernal goiter: an unusual cause of respiratory failure after coronary artery bypass grafting. (16107122)
2005
18
Predictors of airway complications after thyroidectomy for substernal goiter. (15197094)
2004
19
Novel technique for control of mediastinal bleeding during thyroidectomy for substernal goiter. (12742217)
2003
20
Visual vignette. Mediastinal mass due to substernal goiter. (12134778)
2002
21
Detection of a large substernal goiter during Tc-99m tetrofosmin cardiac SPECT imaging. (11391314)
2001
22
Operative management of substernal goiter: analysis of 52 patients. (12056465)
2001
23
Calcified substernal goiter seen on bone scan. (10983765)
2000
24
Surgical management of substernal goiter. (11155771)
2000
25
Surgical treatment of substernal goiter. (11324994)
2000
26
Bilateral recurrent nerve paralysis associated with multinodular substernal goiter: a case report. (10231217)
1999
27
Substernal goiter: clinical experience of 72 cases. (10335714)
1999
28
Use of a Foley catheter in the removal of a substernal goiter. (9817262)
1998
29
Management of substernal goiter. (9818814)
1998
30
Giant mediastinal parathyroid cyst masquerading as a substernal goiter. (9121802)
1997
31
Substernal goiter. (7475073)
1995
32
Surgical management of substernal goiter: analysis of 237 patients. (7661484)
1995
33
Gastric pull-through imitating substernal goiter. (8062480)
1994
34
Surgical management of substernal goiter. (7863290)
1994
35
A case report of substernal goiter. (8014069)
1993
36
Large parathyroid functioning carcinoma (1,200 g) presenting as a substernal goiter. (1560189)
1992
37
Surgery of substernal goiter. (3331229)
1987
38
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 24-1987. A 56-year-old man with a substernal goiter, multiple cutaneous and mucosal lesions, and a positive stool test for occult blood. (3587282)
1987
39
Substernal goiter. Analysis of 80 patients from Massachusetts General Hospital. (3970328)
1985
40
Substernal goiter. (3885887)
1985
41
Sequestered substernal goiter. (6625801)
1983
42
Sequestered substernal goiter. (6679211)
1983
43
Esophageal tracer retention simulating substernal goiter. (845672)
1977
44
Substernal goiter with superior vena caval obstruction. (1129707)
1975
45
Airway obstruction in substernal goiter. Clinical and therapeutic implications. (4777540)
1973
46
Substernal goiter. (5428874)
1970
47
INTRATHORACIC AND SUBSTERNAL GOITER: SOME CONSIDERATION IN MANAGEMENT. (14079533)
1963
48
A consideration of the proper surgical approach for substernal goiter. (14408062)
1960
49
Differential diagnosis, pathology, and treatment of substernal goiter. (13398297)
1957
50
A case of substernal goiter with preoperative symptoms of parathyroid tetany. (15399001)
1950

Variations for Substernal Goiter

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Expression for genes affiliated with Substernal Goiter

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Search GEO for disease gene expression data for Substernal Goiter.

Pathways for genes affiliated with Substernal Goiter

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GO Terms for genes affiliated with Substernal Goiter

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Cellular components related to Substernal Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.5F7, NOTCH1, PTH, TG

Biological processes related to Substernal Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to nutrient levelsGO:00316679.4F7, PTH
2organ regenerationGO:00311009.3F7, NOTCH1

Molecular functions related to Substernal Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.3PTH, TG

Sources for Substernal Goiter

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet