MCID: SBS002
MIFTS: 28

Substernal Goiter malady

Category: Endocrine diseases

Aliases & Classifications for Substernal Goiter

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Aliases & Descriptions for Substernal Goiter:

Name: Substernal Goiter 10 12 65
Retrosternal Thyroid Goiter 10
 
Goiter, Substernal 36

Classifications:



External Ids:

Disease Ontology10 DOID:13200
SNOMED-CT59 190234009, 66392007
MeSH36 D006045
UMLS65 C0018024

Summaries for Substernal Goiter

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MalaCards based summary: Substernal Goiter, also known as retrosternal thyroid goiter, is related to breast cancer and endotheliitis. An important gene associated with Substernal Goiter is F7 (Coagulation Factor VII), and among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include thyroid, breast and endothelial, and related mouse phenotypes are craniofacial and homeostasis/metabolism.

Related Diseases for Substernal Goiter

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Graphical network of the top 20 diseases related to Substernal Goiter:



Diseases related to substernal goiter

Symptoms for Substernal Goiter

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Drugs & Therapeutics for Substernal Goiter

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Substernal Goiter


Cochrane evidence based reviews: goiter, substernal

Genetic Tests for Substernal Goiter

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Anatomical Context for Substernal Goiter

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MalaCards organs/tissues related to Substernal Goiter:

33
Thyroid, Breast, Endothelial, Neutrophil, Prostate, T cells, Monocytes

Animal Models for Substernal Goiter or affiliated genes

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MGI Mouse Phenotypes related to Substernal Goiter:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.0F7, NOTCH1, PTH
2MP:00053767.2CD79A, F7, NOTCH1, PTH, TG

Publications for Substernal Goiter

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Articles related to Substernal Goiter:

(show top 50)    (show all 72)
idTitleAuthorsYear
1
Understanding Racial Differences in Narcolepsy Symptoms May Improve Diagnosis. (26446120)
2015
2
Dynamic interplay between catalytic and lectin domains of GalNAc- transferases modulates protein O-glycosylation. (25939779)
2015
3
Epiblepharon-induced head tilt masquerading as torticollis. (25569166)
2015
4
Diabetic retinopathy and other ocular findings in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study. (24356593)
2014
5
Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by II_B kinase I+ (IKKI+). (24990947)
2014
6
Dual Inhibition of PI3K and mTOR Signaling Pathways Decreases Human Pancreatic Neuroendocrine Tumor Metastatic Progression. (24263107)
2014
7
All-atomic molecular dynamic studies of human CDK8: insight into the A-loop, point mutations and binding with its partner CycC. (24754906)
2014
8
Surgical recanalization of distal middle cerebral artery occlusion due to a coil migration during endovascular coil embolization: a case report. (25340033)
2014
9
Delusional Disorder as a Partial Psychosis. (24421383)
2014
10
Gradual correction of congenital radioulnar synostosis by an osteotomy and Ilizarov external fixation. (23290465)
2013
11
Proteasome inhibitor therapy for WaldenstrAPm's macroglobulinemia. (23562304)
2013
12
Evaluation of biofilm-forming capacity of Moraxella bovis, the primary causative agent of infectious bovine keratoconjunctivitis. (23907059)
2013
13
Risk factors associated with self-reported symptoms of digital ischemia in elite male volleyball players in the Netherlands. (24224476)
2013
14
Prospective Flutemetamol Positron Emission Tomography and Histopathology in Normal Pressure Hydrocephalus. (24296542)
2013
15
Performance of Lynch syndrome predictive models in a multi-center US referral population. (21747416)
2011
16
Cysteine cathepsins in human dentin-pulp complex. (20171366)
2010
17
Ictal bradycardia in an infant following surgical treatment for hemimegalencephaly. (20158665)
2010
18
Promoter methylation analysis of O6-methylguanine-DNA methyltransferase in glioblastoma: detection by locked nucleic acid based quantitative PCR using an imprinted gene (SNURF) as a reference. (20167086)
2010
19
Transcatheter aortic valve implantation in patients with bicuspid aortic valve stenosis. (21087746)
2010
20
Critical role of endogenous heme oxygenase 1 as a tuner of the invasive potential of prostate cancer cells. (19903769)
2009
21
Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study. (18937309)
2008
22
Effects of tumor necrosis factor antagonist treatment on hepatitis C-related immunological abnormalities. (17353164)
2006
23
Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: interactions with genotype and equol production. (16522905)
2006
24
No evidence of parvovirus B19 in tissue samples from patients with polyarteritis nodosa and microscopic polyangiitis as assessed by the polymerase chain reaction. (16474040)
2006
25
High reoperation rates after early treatment of the subluxating hip in children with spastic cerebral palsy. (16932101)
2006
26
Postoperative differentiation between unilateral adrenal adenoma and bilateral adrenal hyperplasia in primary aldosteronism by mRNA expression of the gene CYP11B2. (15248825)
2004
27
Oxytocin requirements at elective cesarean delivery: a dose-finding study. (15516392)
2004
28
Dracunculiasis: a rare cause of breast calcification detected on screening mammography. (14746793)
2004
29
Effect of tamoxifen on serum IL-18, vascular endothelial growth factor and nitric oxide activities in breast carcinoma patients. (15320904)
2004
30
Reoperative retroperitoneal surgery for nonseminomatous germ cell tumor: clinical presentation, patterns of recurrence, and outcome. (14550453)
2003
31
Hyperuricemia, low urine urate excretion and target organ damage in arterial hypertension. (14763658)
2003
32
Enhanced soluble interleukin-5 receptor alpha expression in nasal polyposis. (12752323)
2003
33
Retinoic acid inhibits telomerase activity and downregulates expression but does not affect splicing of hTERT: correlation with cell growth rate inhibition in an in vitro cervical carcinogenesis/multidrug-resistance model. (11777343)
2002
34
Disposition and functions of clarithromycin in human THP-1 monocytes during stimulated and unstimulated conditions. (12760488)
2001
35
Activation of the immune system and coronary artery disease: the role of anti-endothelial cell antibodies. (11166776)
2001
36
Mechanisms of hemorrhage in dengue without circulatory collapse. (11791984)
2001
37
Psychosocial profiles of patients with burning mouth syndrome. (11203740)
2000
38
Relevant prevalence of Mycoplasma hominis and Ureaplasma urealyticum serogroups in HIV-1 infected men without urethritis symptoms. (10968880)
2000
39
Glucose and lactate biosensors based on redox polymer/oxidoreductase nanocomposite thin films. (10905330)
2000
40
Diversity of N-acetylglucosamine-6-O-sulfotransferases: molecular cloning of a novel enzyme with different distribution and specificities. (10913333)
2000
41
Stimulation of femoral trabecular bone growth in ovariectomized rats by human parathyroid hormone (hPTH)-(1-30)NH(2). (10430648)
1999
42
Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6. (9360995)
1997
43
Estrogen receptor-beta mRNA expression in rat ovary: down-regulation by gonadotropins. (9013764)
1997
44
Steady-state levels of mitochondrial messenger RNA species characterize a predominant pathway culminating in apoptosis and shedding of HT29 human colonic carcinoma cells. (8788038)
1996
45
Lack of relationship between an insertion/deletion polymorphism in the angiotensin I-converting enzyme gene and diabetic nephropathy and proliferative retinopathy in IDDM patients. (7729604)
1995
46
A polymorphic (CA)n repeat element maps the human glucokinase gene (GCK) to chromosome 7p. (1740341)
1992
47
Interconversion between apolipoprotein A-I-containing lipoproteins of pre-beta and alpha electrophoretic mobilities. (1479290)
1992
48
Cytosolic epoxide hydrolase in fetal and adult human liver. (6667124)
1983
49
High-pouch imperforate anus treated by electromagnetic bougienage and subsequent perineal repair. (1032894)
1976
50
A new variant of heavy-chain disease (mu-chain disease). (5438427)
1970

Variations for Substernal Goiter

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Expression for genes affiliated with Substernal Goiter

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Search GEO for disease gene expression data for Substernal Goiter.

Pathways for genes affiliated with Substernal Goiter

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Pathways related to Substernal Goiter according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.1CD79A, NOTCH1
29.1CD79A, PTH

GO Terms for genes affiliated with Substernal Goiter

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Biological processes related to Substernal Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell migrationGO:00303359.5F7, NOTCH1
2regulation of gene expressionGO:00104689.1NOTCH1, PTH

Sources for Substernal Goiter

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet