MCID: SDD007
MIFTS: 47

Sudden Cardiac Death malady

Categories: Genetic diseases

Aliases & Classifications for Sudden Cardiac Death

Aliases & Descriptions for Sudden Cardiac Death:

Name: Sudden Cardiac Death 24 29 69
Death Sudden Cardiac 52

Classifications:



Summaries for Sudden Cardiac Death

MalaCards based summary : Sudden Cardiac Death, also known as death sudden cardiac, is related to short qt syndrome 2 and long qt syndrome 9. An important gene associated with Sudden Cardiac Death is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Transmission across Chemical Synapses and Vascular smooth muscle contraction. The drugs Epinephrine and Valproic Acid have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and kidney, and related phenotypes are cardiovascular system and muscle

Related Diseases for Sudden Cardiac Death

Diseases related to Sudden Cardiac Death via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
id Related Disease Score Top Affiliating Genes
1 short qt syndrome 2 31.2 KCNE1 KCNH2 KCNQ1 SCN5A
2 long qt syndrome 9 30.7 MYBPC3 MYH7 TPM1
3 sudden infant death syndrome 29.4 MYH7 SCN5A TPM1
4 cardiac conduction defect 11.7
5 brugada syndrome 11.3
6 cardiomyopathy 11.3
7 coronary artery disease 11.2
8 catecholaminergic polymorphic ventricular tachycardia 11.1
9 arrhythmogenic right ventricular cardiomyopathy 11.1
10 peripartum cardiomyopathy 11.1
11 cardiomyopathy, familial hypertrophic 11.1
12 cardiomyopathy, hypertrophic 6 11.0
13 ventricular septal defect 1 11.0
14 cardiac arrhythmia, ankyrin-b-related 11.0
15 ventricular septal defect 3 11.0
16 ventricular septal defect 2 11.0
17 scapuloperoneal syndrome, neurogenic, kaeser type 10.8
18 long qt syndrome 2 10.8
19 long qt syndrome 13 10.8
20 short qt syndrome 1 10.8
21 cardiomyopathy, hypertrophic, 10 10.8
22 andersen syndrome 10.8
23 cardiomyopathy, hypertrophic, 14 10.8
24 flnc-related familial restrictive cardiomyopathy 10.8
25 long qt syndrome 14 10.8
26 cardiomyopathy, hypertrophic, 13 10.8
27 cardiomyopathy, hypertrophic, 11 10.8
28 long qt syndrome-3 10.8
29 cardiomyopathy, hypertrophic, 3 10.8
30 cardiomyopathy, dilated, 1kk 10.8
31 cardiomyopathy, hypertrophic, 8 10.8
32 cardiomyopathy, hypertrophic, 15 10.8
33 cardiomyopathy, hypertrophic, 25 10.8
34 cardiomyopathy, dilated, 1c, with or without lvnc 10.8
35 short qt syndrome 3 10.8
36 cardiomyopathy, infantile hypertrophic 10.8
37 long qt syndrome 1 10.8
38 cardiomyopathy, hypertrophic, 19 10.8
39 cardiomyopathy, hypertrophic, 16 10.8
40 cardiomyopathy, hypertrophic, 20 10.8
41 cardiomyopathy, hypertrophic, 7 10.8
42 cardiomyopathy, hypertrophic, 2 10.8
43 cardiomyopathy, hypertrophic, 18 10.8
44 cardiomyopathy, hypertrophic, 12 10.8
45 long qt syndrome 12 10.8
46 cardiomyopathy, dilated, 1aa, with or without lvnc 10.8
47 cardiomyopathy, hypertrophic, 4 10.8
48 cardiomyopathy, hypertrophic, 17 10.8
49 long qt syndrome 15 10.8
50 long qt syndrome 6 10.8

Graphical network of the top 20 diseases related to Sudden Cardiac Death:



Diseases related to Sudden Cardiac Death

Symptoms & Phenotypes for Sudden Cardiac Death

MGI Mouse Phenotypes related to Sudden Cardiac Death:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.56 KCNQ1 MYBPC3 MYH7 SCN5A AKAP10 KCNH2
2 muscle MP:0005369 9.1 KCNQ1 MYBPC3 MYH7 SCN5A KCNH2 KCNJ2

Drugs & Therapeutics for Sudden Cardiac Death

Drugs for Sudden Cardiac Death (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 373)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 1 51-43-4 5816
2
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
3
Spironolactone Approved Phase 4,Phase 3,Phase 2 1952-01-7, 52-01-7 5833
4
Amlodipine Approved Phase 4,Phase 3 88150-42-9 2162
5
Carvedilol Approved, Investigational Phase 4,Phase 2 72956-09-3 2585
6
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
7
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
8
Heparin Approved, Investigational Phase 4,Phase 2 9005-49-6 772 46507594
9
Dopamine Approved Phase 4,Phase 2,Phase 3 51-61-6, 62-31-7 681
10
Nicotine Approved Phase 4 54-11-5 942 89594
11
Glyburide Approved Phase 4 10238-21-8 3488
12
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
13
Pravastatin Approved Phase 4 81093-37-0 54687
14
Progesterone Approved, Vet_approved Phase 4,Phase 2 57-83-0 5994
15
Testosterone Approved, Investigational Phase 4 58-22-0 6013
16
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
17
Pantoprazole Approved Phase 4 102625-70-7 4679
18
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
19
Nicorandil Approved Phase 4 65141-46-0 47528
20
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
21
Chlorthalidone Approved Phase 4,Phase 3 77-36-1 2732
22
Olmesartan Approved, Investigational Phase 4,Phase 3 144689-24-7, 144689-63-4 158781 130881
23
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
24
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
25
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
26
Everolimus Approved Phase 4 159351-69-6 6442177
27
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
28
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
29
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
30
Domperidone Approved, Investigational, Vet_approved Phase 4 57808-66-9 3151
31
Ibutilide Approved Phase 4,Phase 2 122647-32-9, 122647-31-8 60753
32
Methyltestosterone Approved Phase 4 58-18-4 6010
33
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
34
Warfarin Approved Phase 4,Phase 2 81-81-2 6691 54678486
35
Rivaroxaban Approved Phase 4 366789-02-8
36
Ticagrelor Approved Phase 4,Phase 2,Phase 3 274693-27-5 9871419
37
Dalteparin Approved Phase 4,Phase 2 9041-08-1
38
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
39
Gliclazide Approved Phase 4 21187-98-4 3475
40
Glimepiride Approved Phase 4 93479-97-1 3476
41
Metformin Approved Phase 4 657-24-9 14219 4091
42
Clopidogrel Approved, Nutraceutical Phase 4,Phase 3,Phase 2 120202-66-6, 113665-84-2 60606
43
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
44
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
45
Phytonadione Approved, Nutraceutical Phase 4 84-80-0 4812 5284607
46
Angiotensin II Phase 4,Phase 3 68521-88-0, 11128-99-7 65143 172198
47 calcium channel blockers Phase 4,Phase 2,Phase 3
48 diuretics Phase 4,Phase 3,Phase 2
49
protease inhibitors Phase 4,Phase 3
50 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 499)
id Name Status NCT ID Phase
1 Impact of Acarbose on Abnormal Glucose Regulation in Patients With Coronary Artery Disease (AAA Trial) Unknown status NCT00858676 Phase 4
2 IRIS : Use of Implantable Defibrillator in High-Risk Patients Early After Acute Myocardial Infarction Unknown status NCT00157768 Phase 4
3 Clinical and Therapeutic Implications of Fibrosis in Hypertrophic Cardiomyopathy Unknown status NCT00879060 Phase 4
4 Effects of Atrial Rate-adaptive Pacing on Exercise Capacity in Patients With Chronic Heart Failure Complicated by Chronotropic Incompetence Unknown status NCT01016431 Phase 4
5 Study of Qiliqiangxin Capsule to Treat Dilated Cardiomyopathy Unknown status NCT01293903 Phase 4
6 A Randomized Trial of Angiotensin Receptor bLocker,Fimasartan, in Aortic Stenosis (ALFA Trial) Unknown status NCT01589380 Phase 4
7 Sodium Bicarbonate in Cardiopulmonary Resuscitation Unknown status NCT01377337 Phase 4
8 Out-of Hospital Resuscitation Study Unknown status NCT00196248 Phase 4
9 The Benefit of Prophylactic Anticonvulsant in Post Cardiac Arrest Syndrome With Induced Mild Hypothermia Unknown status NCT01083784 Phase 4
10 Identification of Carnitine-Responsive Cardiomyopathy Unknown status NCT01904396 Phase 4
11 An Observational Study to Assess the Risk of Out-of-Hospital Sudden Cardiac Death in Users of Domperidone, Users of Proton Pump Inhibitors, and Users of Metoclopramide Completed NCT01907633 Phase 4
12 Neuron Specific Enolase (NSE) as Outcome Parameter of Cooling Therapy After Survived Sudden Cardiac Death Completed NCT01102153 Phase 4
13 Protective Effect of EPA on Cardiovascular Events Completed NCT00231738 Phase 4
14 'Effect of CRT on Defibrillation Threshold Estimates' Study Completed NCT00626093 Phase 4
15 POWER (Pulse Width Optimized Waveform Evaluation Trial) Completed NCT00311181 Phase 4
16 Long Term Integrity Follow-up Evaluation Completed NCT00848835 Phase 4
17 Predictive Risk Stratification Through T Variability in ICD Patients Without Pacing Indications Completed NCT00560768 Phase 4
18 Survival of Patients With Primary Prophylactic ICD Indication Completed NCT00619593 Phase 4
19 Comparison of Valsartan With Amlodipine in Hypertensive Patients With Glucose Intolerance Completed NCT00129233 Phase 4
20 The Use of Dual Chamber ICD With Special Programmed Features to Lower the Risk of Inappropriate Shock Completed NCT00787800 Phase 4
21 Effects of Testosterone on Myocardial Repolarization Completed NCT03126656 Phase 4
22 Physiologic Evaluation of Anomalous Right Coronary Artery Stenosis Completed NCT01133054 Phase 4
23 OptiLink HF Study: Optimization of Heart Failure Management Using Medtronic OptiVol Fluid Status Monitoring and CareLink Network Completed NCT00769457 Phase 4
24 Trop-Shock DFT-testing Versus None Completed NCT01230086 Phase 4
25 Carvedilol Post-intervention Long-term Administration in Large-scale Trial Completed NCT01155635 Phase 4
26 COOL-Trial: Outcome With Invasive and Non-invasive Cooling After Cardiac Arrest Completed NCT00843297 Phase 4
27 Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese(MEGA Study) Completed NCT00211705 Phase 4
28 Multicenter Automatic Defibrillator Implantation Trial - Reduce Inappropriate Therapy Completed NCT00947310 Phase 4
29 DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients. Completed NCT00478933 Phase 4
30 A New Strategy Regarding Discontinuation of Dual Antiplatelet Completed NCT01145079 Phase 4
31 Combination of OLMesartan and CCB or Low Dose Diuretics in High Risk Elderly Hypertensive Patients Study (COLM-Study) Completed NCT00454662 Phase 4
32 Assessment of Translesional Markers and Metabolomics Completed NCT00321139 Phase 4
33 Treatment of Predominant Central Sleep Apnoea by Adaptive Servo Ventilation in Patients With Heart Failure Completed NCT00733343 Phase 4
34 Medtronic Genetic Arrhythmia Markers for Early Detection (GAME Study) Completed NCT00664807 Phase 4
35 Resistance to Aspirin and/or Clopidogrel Among Patients With PAD. Completed NCT00262561 Phase 4
36 Hemodynamic Responses to Tracheal Intubation Direct Laryngoscope and Videolaryngoscope in Elderly Patients Completed NCT02816775 Phase 4
37 PRIDE: Preventing Respiratory Illnesses During Childhood Study Completed NCT00927264 Phase 4
38 Letigen® and Cardiovascular Morbidity Completed NCT00692666 Phase 4
39 Study to Characterize Atrial Fibrillation in CHF Patients Indicated for CRT Completed NCT00156728 Phase 4
40 OlmeSartan and Calcium Antagonists Randomized (OSCAR) Study Completed NCT00134160 Phase 4
41 Valsartan in Elderly Isolated Systolic Hypertension Study Completed NCT00151229 Phase 4
42 Implantable Cardioverter Defibrillator Versus Optimal Medical Therapy In Patients With Variant Angina Manifesting as Aborted Sudden Cardiac Death Recruiting NCT02845531 Phase 4
43 Evaluation of the Entresto Effect on Sympathic Nervous System in Patient With Heart Failure Recruiting NCT02787798 Phase 4
44 Comparing the Effects of Spironolactone With Chlortalidone on LV Mass in Patients With CKD Recruiting NCT02502981 Phase 4
45 P3AMI Antiplatelet Trial Recruiting NCT02376283 Phase 4
46 Influence of Testosterone Administration on Drug-Induced QT Interval Prolongation and Torsades de Pointes Recruiting NCT02513940 Phase 4
47 Effect on Vascular Calcification of Replacing Warfarin by Rivaroxaban With or Without VitK2 in Hemodialysis Patients Recruiting NCT02610933 Phase 4
48 Prospective Study of End Stage Renal Disease Patients With Coronary Artery Disease Treated by Oral Nicorandil Active, not recruiting NCT01475123 Phase 4
49 Efficacy of Implantable Cardioverter Defibrillator in Patients With Non-ischemic Systolic Heart Failure on Mortality Active, not recruiting NCT00541268 Phase 4
50 Thiazolidinediones Or Sulphonylureas and Cardiovascular Accidents.Intervention Trial Active, not recruiting NCT00700856 Phase 4

Search NIH Clinical Center for Sudden Cardiac Death

Genetic Tests for Sudden Cardiac Death

Genetic tests related to Sudden Cardiac Death:

id Genetic test Affiliating Genes
1 Sudden Cardiac Death 29 24

Anatomical Context for Sudden Cardiac Death

MalaCards organs/tissues related to Sudden Cardiac Death:

39
Heart, Testes, Kidney, Brain, Tonsil, Cardiac Myocytes, Thyroid

Publications for Sudden Cardiac Death

Articles related to Sudden Cardiac Death:

(show top 50) (show all 311)
id Title Authors Year
1
Comparative Risk of Ventricular Arrhythmia and Sudden Cardiac Death Across Antidepressants in Patients With Depressive Disorders. ( 27941418 )
2017
2
Genetic anticipation in a special form of hypertrophic cardiomyopathy with sudden cardiac death in a family with 74 members across 5 generations. ( 28296734 )
2017
3
Looking forward: PACES Task Force on prevention of sudden cardiac death in the young: a comprehensive approach to a preventable problem. ( 28084975 )
2017
4
Implantable cardioverter-defibrillator therapy among patients with non-ischaemic vs. ischaemic cardiomyopathy for primary prevention of sudden cardiac death. ( 28082419 )
2017
5
Gender differences in sudden cardiac death in the young-a nationwide study. ( 28061807 )
2017
6
2016 AHA/ACC Clinical Performance and Quality Measures for Prevention of Sudden Cardiac Death: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures. ( 27993943 )
2017
7
Comments on Letter to the Editor entitled: "Role of electrophysiological evaluation for the best device choice to prevent sudden cardiac death in patients with Myotonic Dystrophy Type1 and Emery Dreifuss Muscular Dystrophy". ( 28291654 )
2017
8
Sudden cardiac death in the young: the value of exercise testing. ( 28084955 )
2017
9
Role of electrophysiological evaluation for the best device choice to prevent sudden cardiac death in patients with Myotonic Dystrophy Type 1 and Emery Dreifuss Muscular Dystrophy. ( 28237579 )
2017
10
Sudden cardiac death and chronic kidney disease: From pathophysiology to treatment strategies. ( 27174593 )
2016
11
Value of the QRS-T area angle in improving the prediction of sudden cardiac death after acute coronary syndromes. ( 27203188 )
2016
12
Development and Validation of a Sudden Cardiac Death Prediction Model for the General Population. ( 27542394 )
2016
13
Predictors of Sudden Cardiac Death in Doberman Pinschers with Dilated Cardiomyopathy. ( 27177626 )
2016
14
Medico-legal perspectives on sudden cardiac death in young athletes. ( 27654714 )
2016
15
Syncope and sudden cardiac death: some answers to clinical challenges. ( 27190173 )
2016
16
Sudden Cardiac Death: Autopsy Findings in 7200 Cases Between 2001 and 2015. ( 27973393 )
2016
17
Hutterite-type cataract maps to chromosome 6p21.32-p21.31, cosegregates with a homozygous mutation in LEMD2, and is associated with sudden cardiac death. ( 26788539 )
2016
18
Sudden cardiac death due to deficiency of the mitochondrial inorganic pyrophosphatase PPA2. ( 27523597 )
2016
19
Anatomopathological changes of the cardiac conduction system in sudden cardiac death, particularly in infants: advances over the last 25 years. ( 27616614 )
2016
20
Multiple Giant Coronary Artery Aneurysms: A Rare Cause of Sudden Cardiac Death. ( 27859306 )
2016
21
Sudden cardiac death from structural heart diseases in adults: imaging findings with cardiovascular computed tomography and magnetic resonance. ( 27139460 )
2016
22
Sudden Cardiac Death of a Body Packer Due to Cocaine Cardiotoxicity. ( 27932899 )
2016
23
Depression and Risk of Sudden Cardiac Death and Arrhythmias: A Meta-Analysis. ( 27627224 )
2016
24
Potential roles of the wearable cardioverter-defibrillator in acute phase care of patients at high risk of sudden cardiac death: A single-center Japanese experience. ( 27595899 )
2016
25
Cardiorespiratory fitness and exercise-induced ST segment depression in assessing the risk of sudden cardiac death in men. ( 27604814 )
2016
26
Hemoglobin A1c levels and risk of sudden cardiac death: A nested case-control study. ( 27591826 )
2016
27
Amiodarone for the Prevention of Sudden Cardiac Death. ( 27929253 )
2016
28
Data on benefits of screening for sudden cardiac death are withheld. ( 27098196 )
2016
29
Should the Subcutaneous Implantable Defibrillator Be the First Choice for Primary Prevention of Sudden Cardiac Death? ( 27838348 )
2016
30
Macrolides use and the risk of sudden cardiac death. ( 27086751 )
2016
31
Prevention of sudden cardiac death by the wearable cardioverter defibrillator in a young patient with cardiac sarcoidosis. ( 27920335 )
2016
32
Harms and benefits of screening young people to prevent sudden cardiac death. ( 27097983 )
2016
33
Kidney function and sudden cardiac death in the community: The Atherosclerosis Risk in Communities (ARIC) Study. ( 27659882 )
2016
34
Sudden cardiac death and late arrhythmias after the Fontan operation. ( 27545004 )
2016
35
Validation of the 2014 European Society of Cardiology Sudden Cardiac Death Risk Prediction Model in Hypertrophic Cardiomyopathy in a Reference Center in South America. ( 27189816 )
2016
36
Preventing sudden cardiac death in athletes. ( 27098379 )
2016
37
Novel truncating desmoplakin mutation as a potential cause of sudden cardiac death in a family. ( 27698334 )
2016
38
Sudden cardiac death: A reappraisal. ( 27665048 )
2016
39
Abiraterone acetate as a possible cause of sudden cardiac death. ( 27569102 )
2016
40
Ion Channel Remodeling-A Potential Mechanism Linking Sleep Apnea and Sudden Cardiac Death. ( 27543309 )
2016
41
Inverted U-Shaped Relation Between the Risk of Sudden Cardiac Death and Maximal Left Ventricular Wall Thickness in Hypertrophic Cardiomyopathy. ( 27217341 )
2016
42
Role of risk stratification and genetics in sudden cardiac death. ( 27875062 )
2016
43
Chronic obstructive pulmonary disease and risk of sudden cardiac death. ( 27085657 )
2016
44
Electrocardiographic predictors of mortality and sudden cardiac death in patients with end stage renal disease on hemodialysis. ( 27554424 )
2016
45
Familial Atrial Septal Defect and Sudden Cardiac Death: Identification of a Novel NKX2-5 Mutation and a Review of the Literature. ( 26679770 )
2016
46
Low Heart Rate Variability in a 2-Minute Electrocardiogram Recording Is Associated with an Increased Risk of Sudden Cardiac Death in the General Population: The Atherosclerosis Risk in Communities Study. ( 27551828 )
2016
47
Exome Sequencing Identifies a Novel LMNA Splice-Site Mutation and Multigenic Heterozygosity of Potential Modifiers in a Family with Sick Sinus Syndrome, Dilated Cardiomyopathy, and Sudden Cardiac Death. ( 27182706 )
2016
48
Polymorphisms in the GNAS Gene as Predictors of Ventricular Tachyarrhythmias and Sudden Cardiac Death: Results From the DISCOVERY Trial and Oregon Sudden Unexpected Death Study. ( 27895044 )
2016
49
Subcutaneous Implantable Defibrillator in an acromegalic pregnant woman for secondary prevention of sudden cardiac death: When (2) technologies save (2) lives. ( 27543699 )
2016
50
Sudden cardiac death: a nationwide cohort study among the young. ( 27910804 )
2016

Variations for Sudden Cardiac Death

ClinVar genetic disease variations for Sudden Cardiac Death:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 PLN NM_002667.4(PLN): c.116T> G (p.Leu39Ter) single nucleotide variant Pathogenic/Likely pathogenic rs111033560 GRCh37 Chromosome 6, 118880200: 118880200
2 DSP NM_004415.3(DSP): c.2528C> A (p.Ser843Ter) single nucleotide variant Pathogenic rs1057518920 GRCh37 Chromosome 6, 7575619: 7575619

Copy number variations for Sudden Cardiac Death from CNVD:

7 (show all 32)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 16658 1 128900000 142600000 Deletion Sudden cardiac death
2 17395 1 142600000 155000000 Deletion S100A1 Sudden cardiac death
3 29860 1 237205701 237997288 Gain RYR2 Sudden cardiac death
4 38181 10 1 6600000 Gain Sudden cardiac death
5 59687 11 77100000 92800000 Deletion KCNA4 Sudden cardiac death
6 73255 12 92600000 120700000 Deletion ATP2A2 Sudden cardiac death
7 74068 13 10000000 16300000 Deletion Sudden cardiac death
8 74687 13 110300000 115169878 Gain Sudden cardiac death
9 77098 13 40100000 45200000 Gain Sudden cardiac death
10 84232 14 24600000 33300000 Deletion TINF2 Sudden cardiac death
11 95625 15 78300000 102531392 Gain Sudden cardiac death
12 101480 16 38600000 52600000 Deletion Sudden cardiac death
13 119791 18 17200000 19000000 Deletion Sudden cardiac death
14 119992 18 19000000 25000000 Deletion Sudden cardiac death
15 124165 19 1 6900000 Gain Sudden cardiac death
16 134550 2 102700000 110200000 Gain Sudden cardiac death
17 138742 2 169700000 183000000 Gain Sudden cardiac death
18 139544 2 183000000 189400000 Gain Sudden cardiac death
19 160068 21 6800000 16400000 Gain Sudden cardiac death
20 166127 3 1 8700000 Deletion ITPR1 Sudden cardiac death
21 166128 3 1 8700000 Gain Sudden cardiac death
22 170551 3 155838336 156256927 Deletion KCNAB1 Sudden cardiac death
23 170851 3 160700000 167600000 Gain TERC Sudden cardiac death
24 191731 5 1 9800000 Gain TERT Sudden cardiac death
25 196534 5 168500000 180915260 Gain Sudden cardiac death
26 208074 6 164500000 171115067 Gain Sudden cardiac death
27 217131 7 1 7300000 Gain Sudden cardiac death
28 218560 7 114600000 117400000 Gain Sudden cardiac death
29 221932 7 147900000 159138663 Gain KCNH2 Sudden cardiac death
30 244984 9 1 9000000 Gain Sudden cardiac death
31 247561 9 130300000 141213431 Gain Sudden cardiac death
32 254437 9 65900000 68700000 Deletion gain CMD1B Sudden cardiac death

Expression for Sudden Cardiac Death

Search GEO for disease gene expression data for Sudden Cardiac Death.

Pathways for Sudden Cardiac Death

Pathways related to Sudden Cardiac Death according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.69 CALM2 KCNH2 KCNJ2 KCNJ5 KCNQ1
2
Show member pathways
12.52 CALM2 KCNE1 KCNJ2 KCNJ5 KCNQ1 MYH7
3
Show member pathways
12.43 CALM2 KCNJ2 KCNJ5 KCNQ1
4
Show member pathways
12.29 CALM2 KCNE1 KCNH2 KCNJ2 KCNQ1 MYBPC3
5 12.09 CALM2 KCNE1 KCNH2 KCNJ2 KCNJ5 KCNQ1
6
Show member pathways
11.92 MYBPC3 MYH7 TPM1
7
Show member pathways
11.89 CALM2 KCNJ2 KCNQ1
8
Show member pathways
11.88 KCNH2 KCNJ2 KCNJ5 KCNQ1
9 11.87 KCNH2 KCNQ1 SCN5A
10
Show member pathways
11.5 CALM2 KCNE1 KCNQ1 SCN5A
11 11.09 CALM2 TPM1
12 11 ANK2 SCN5A
13 10.92 ANK2 KCNE1 KCNH2 KCNJ2 KCNJ5 KCNQ1
14 10.82 KCNE1 KCNJ2 KCNQ1

GO Terms for Sudden Cardiac Death

Cellular components related to Sudden Cardiac Death according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.65 ANK2 KCNE1 KCNQ1
2 sarcomere GO:0030017 9.56 CALM2 MYBPC3 MYH7 TPM1
3 intercalated disc GO:0014704 9.5 ANK2 KCNJ2 SCN5A
4 myofibril GO:0030016 9.49 MYH7 TPM1
5 M band GO:0031430 9.46 ANK2 MYBPC3
6 T-tubule GO:0030315 9.46 ANK2 KCNJ2 KCNJ5 SCN5A
7 myosin filament GO:0032982 9.4 MYBPC3 MYH7
8 A band GO:0031672 9.37 ANK2 MYBPC3
9 Z disc GO:0030018 9.35 ANK2 KCNE1 MYBPC3 MYH7 SCN5A
10 voltage-gated potassium channel complex GO:0008076 9.02 KCNE1 KCNH2 KCNJ2 KCNJ5 KCNQ1
11 plasma membrane GO:0005886 10.09 AKAP10 ANK2 CALM2 KCNE1 KCNH2 KCNJ2

Biological processes related to Sudden Cardiac Death according to GeneCards Suite gene sharing:

(show all 40)
id Name GO ID Score Top Affiliating Genes
1 regulation of ion transmembrane transport GO:0034765 9.95 KCNE1 KCNH2 KCNJ2 KCNJ5 KCNQ1 SCN5A
2 ion transmembrane transport GO:0034220 9.93 CALM2 KCNH2 KCNQ1 SCN5A
3 potassium ion transport GO:0006813 9.91 KCNE1 KCNH2 KCNJ2 KCNJ5 KCNQ1
4 potassium ion transmembrane transport GO:0071805 9.89 KCNE1 KCNH2 KCNJ2 KCNQ1
5 cardiac conduction GO:0061337 9.83 KCNE1 KCNH2 KCNJ2 KCNQ1 SCN5A
6 muscle contraction GO:0006936 9.82 CALM2 MYH7 TPM1
7 regulation of heart rate GO:0002027 9.8 ANK2 CALM2 MYH7 SCN5A
8 muscle filament sliding GO:0030049 9.77 MYBPC3 MYH7 TPM1
9 positive regulation of potassium ion transmembrane transport GO:1901381 9.76 KCNE1 KCNH2 KCNJ2 KCNQ1
10 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.75 MYBPC3 MYH7 TPM1
11 cardiac muscle cell action potential involved in contraction GO:0086002 9.74 KCNE1 KCNJ2 SCN5A
12 regulation of cardiac muscle cell contraction GO:0086004 9.73 ANK2 KCNJ2 SCN5A
13 regulation of membrane repolarization GO:0060306 9.72 KCNH2 KCNJ2 KCNQ1
14 atrial cardiac muscle cell action potential GO:0086014 9.71 ANK2 KCNQ1 SCN5A
15 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.71 KCNE1 KCNH2 KCNJ2 KCNQ1
16 potassium ion export GO:0071435 9.7 KCNE1 KCNH2 KCNQ1
17 sarcomere organization GO:0045214 9.68 MYBPC3 TPM1
18 positive regulation of ATPase activity GO:0032781 9.68 MYBPC3 TPM1
19 regulation of heart contraction GO:0008016 9.67 KCNQ1 TPM1
20 membrane depolarization during action potential GO:0086010 9.67 KCNH2 SCN5A
21 striated muscle contraction GO:0006941 9.67 MYBPC3 MYH7
22 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.67 KCNE1 KCNH2 KCNJ5 KCNQ1
23 potassium ion import GO:0010107 9.66 KCNJ2 KCNJ5
24 regulation of cardiac muscle contraction GO:0055117 9.66 ANK2 CALM2
25 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.65 ANK2 CALM2
26 regulation of potassium ion transmembrane transport GO:1901379 9.65 KCNE1 KCNH2
27 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.65 ANK2 KCNE1 KCNH2 KCNQ1 SCN5A
28 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.64 KCNJ2 SCN5A
29 membrane repolarization GO:0086009 9.64 KCNE1 KCNQ1
30 SA node cell action potential GO:0086015 9.63 ANK2 SCN5A
31 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.62 KCNQ1 SCN5A
32 membrane depolarization during SA node cell action potential GO:0086046 9.62 ANK2 SCN5A
33 membrane repolarization during action potential GO:0086011 9.62 KCNE1 KCNH2 KCNJ2 KCNQ1
34 membrane repolarization during atrial cardiac muscle cell action potential GO:0098914 9.61 KCNJ5 KCNQ1
35 potassium ion export across plasma membrane GO:0097623 9.61 KCNH2 KCNQ1
36 ventricular cardiac muscle cell action potential GO:0086005 9.55 ANK2 KCNE1 KCNH2 KCNQ1 SCN5A
37 cardiac muscle contraction GO:0060048 9.43 KCNH2 KCNQ1 MYBPC3 MYH7 SCN5A TPM1
38 regulation of heart rate by cardiac conduction GO:0086091 9.17 ANK2 KCNE1 KCNH2 KCNJ2 KCNJ5 KCNQ1
39 transport GO:0006810 10.16 KCNE1 KCNH2 KCNJ2 KCNJ5 KCNQ1 SCN5A
40 ion transport GO:0006811 10.06 KCNE1 KCNH2 KCNJ2 KCNJ5 KCNQ1 SCN5A

Molecular functions related to Sudden Cardiac Death according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.7 KCNQ1 MYH7 SCN5A
2 ion channel binding GO:0044325 9.67 ANK2 CALM2 KCNQ1 SCN5A
3 potassium channel activity GO:0005267 9.65 KCNE1 KCNH2 KCNQ1
4 voltage-gated potassium channel activity GO:0005249 9.63 KCNE1 KCNH2 KCNQ1
5 scaffold protein binding GO:0097110 9.61 KCNH2 KCNQ1 SCN5A
6 voltage-gated ion channel activity GO:0005244 9.55 KCNH2 KCNJ2 KCNJ5 KCNQ1 SCN5A
7 titin binding GO:0031432 9.51 CALM2 MYBPC3
8 inward rectifier potassium channel activity GO:0005242 9.5 KCNH2 KCNJ2 KCNJ5
9 G-protein activated inward rectifier potassium channel activity GO:0015467 9.49 KCNJ2 KCNJ5
10 delayed rectifier potassium channel activity GO:0005251 9.43 KCNE1 KCNH2 KCNQ1
11 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization GO:0086089 9.4 KCNJ5 KCNQ1
12 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 9.26 KCNE1 KCNH2 KCNJ5 KCNQ1
13 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 8.92 KCNE1 KCNH2 KCNJ2 KCNQ1

Sources for Sudden Cardiac Death

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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