Aliases & Classifications for Sudden Cardiac Death

MalaCards integrated aliases for Sudden Cardiac Death:

Name: Sudden Cardiac Death 24 29 69
Death Sudden Cardiac 52

Classifications:



Summaries for Sudden Cardiac Death

MalaCards based summary : Sudden Cardiac Death, also known as death sudden cardiac, is related to long qt syndrome 9 and short qt syndrome 1. An important gene associated with Sudden Cardiac Death is DSP (Desmoplakin), and among its related pathways/superpathways are Vascular smooth muscle contraction and Cardiac conduction. The drugs Acarbose and Spironolactone have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and kidney, and related phenotypes are cardiovascular system and muscle

Related Diseases for Sudden Cardiac Death

Diseases related to Sudden Cardiac Death via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 169)
id Related Disease Score Top Affiliating Genes
1 long qt syndrome 9 29.6 MYBPC3 MYH7 TPM1
2 short qt syndrome 1 29.4 ANK2 KCNE1 KCNH2 KCNJ2 KCNQ1 SCN5A
3 sudden infant death syndrome 28.2 DSP MYH7 SCN5A TPM1
4 cardiac conduction defect 11.6
5 brugada syndrome 11.3
6 cardiomyopathy 11.3
7 coronary artery disease 11.1
8 catecholaminergic polymorphic ventricular tachycardia 11.1
9 arrhythmogenic right ventricular cardiomyopathy 11.1
10 peripartum cardiomyopathy 11.1
11 cardiomyopathy, familial hypertrophic 11.1
12 cardiac arrhythmia, ankyrin-b-related 10.9
13 ventricular septal defect 3 10.9
14 ventricular septal defect 2 10.9
15 cardiomyopathy, hypertrophic 6 10.9
16 ventricular septal defect 1 10.9
17 cardiomyopathy, hypertrophic, 20 10.8
18 cardiomyopathy, hypertrophic, 2 10.8
19 cardiomyopathy, dilated, 1aa, with or without lvnc 10.8
20 long qt syndrome 15 10.8
21 cardiomyopathy, familial hypertrophic, 9 10.8
22 scapuloperoneal syndrome, neurogenic, kaeser type 10.8
23 cardiomyopathy, hypertrophic, 13 10.8
24 long qt syndrome-3 10.8
25 cardiomyopathy, hypertrophic, 8 10.8
26 3-methylglutaconic aciduria, type v 10.8
27 ventricular tachycardia, catecholaminergic polymorphic, 3 10.8
28 cardiomyopathy, hypertrophic, 16 10.8
29 cardiomyopathy, hypertrophic, 18 10.8
30 long qt syndrome-11 10.8
31 cardiomyopathy, familial hypertrophic, 26 10.8
32 long qt syndrome 2 10.8
33 cardiomyopathy, dilated, 1kk 10.8
34 cardiomyopathy, hypertrophic, 15 10.8
35 cardiomyopathy, dilated, 1c, with or without lvnc 10.8
36 long qt syndrome 1 10.8
37 short qt syndrome 2 10.8
38 cardiomyopathy, hypertrophic, 12 10.8
39 cardiomyopathy, hypertrophic, 4 10.8
40 long qt syndrome-10 10.8
41 long qt syndrome 13 10.8
42 cardiomyopathy, hypertrophic, 10 10.8
43 cardiomyopathy, hypertrophic, 14 10.8
44 long qt syndrome 14 10.8
45 cardiomyopathy, hypertrophic, 11 10.8
46 cardiomyopathy, hypertrophic, 3 10.8
47 cardiomyopathy, hypertrophic, 25 10.8
48 naxos disease 10.8
49 short qt syndrome 3 10.8
50 cardiomyopathy, hypertrophic, 19 10.8

Graphical network of the top 20 diseases related to Sudden Cardiac Death:



Diseases related to Sudden Cardiac Death

Symptoms & Phenotypes for Sudden Cardiac Death

MGI Mouse Phenotypes related to Sudden Cardiac Death:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.61 AKAP10 DSP KCNH2 KCNJ2 KCNJ5 KCNQ1
2 muscle MP:0005369 9.17 SCN5A DSP KCNH2 KCNJ2 KCNQ1 MYBPC3

Drugs & Therapeutics for Sudden Cardiac Death

Drugs for Sudden Cardiac Death (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 228)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
2
Spironolactone Approved Phase 4,Phase 2 1952-01-7, 52-01-7 5833
3
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
4 Racepinephrine Approved Phase 4,Phase 2
5
Dexlansoprazole Approved Phase 4 138530-94-6, 103577-45-3 9578005
6
Domperidone Approved, Investigational, Vet_approved Phase 4 57808-66-9 3151
7
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
8
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
9
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
10
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
11
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
12
Pantoprazole Approved Phase 4 102625-70-7 4679
13
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
14
Amlodipine Approved Phase 4 88150-42-9 2162
15
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
16
Methyltestosterone Approved Phase 4 58-18-4 6010
17
Testosterone Approved, Investigational Phase 4 58-22-0 6013
18
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
19
Carvedilol Approved, Investigational Phase 4,Phase 2 72956-09-3 2585
20
Pravastatin Approved Phase 4 81093-37-0 54687
21
Nicorandil Approved Phase 4 65141-46-0 47528
22
Chlorthalidone Approved Phase 4 77-36-1 2732
23
Ticlopidine Approved Phase 4 55142-85-3 5472
24
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
25
Clopidogrel Approved, Nutraceutical Phase 4,Phase 2 120202-66-6, 113665-84-2 60606
26
Angiotensin II Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
27 Cardiac Glycosides Phase 4
28 Glycoside Hydrolase Inhibitors Phase 4
29 Hypoglycemic Agents Phase 4
30 diuretics Phase 4,Phase 2
31 Diuretics, Potassium Sparing Phase 4,Phase 3
32 Hormone Antagonists Phase 4
33 Hormones Phase 4
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
35 Mineralocorticoid Receptor Antagonists Phase 4,Phase 2
36 Mineralocorticoids Phase 4,Phase 2
37 Natriuretic Agents Phase 4
38 Angiotensin Receptor Antagonists Phase 4
39 Epinephryl borate Phase 4,Phase 2
40 Antiemetics Phase 4
41 Autonomic Agents Phase 4,Phase 3,Phase 2
42 Dopamine Agents Phase 4
43 Dopamine Antagonists Phase 4
44 Dopamine D2 Receptor Antagonists Phase 4
45 Gastrointestinal Agents Phase 4,Phase 2
46 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
47 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
48
Proton pump inhibitors Phase 4
49 Eicosapentaenoic acid ethyl ester Phase 4
50 Platelet Aggregation Inhibitors Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 300)

id Name Status NCT ID Phase Drugs
1 Impact of Acarbose on Abnormal Glucose Regulation in Patients With Coronary Artery Disease (AAA Trial) Unknown status NCT00858676 Phase 4 acarbose
2 IRIS : Use of Implantable Defibrillator in High-Risk Patients Early After Acute Myocardial Infarction Unknown status NCT00157768 Phase 4
3 Clinical and Therapeutic Implications of Fibrosis in Hypertrophic Cardiomyopathy Unknown status NCT00879060 Phase 4 spironolactone
4 Effects of Atrial Rate-adaptive Pacing on Exercise Capacity in Patients With Chronic Heart Failure Complicated by Chronotropic Incompetence Unknown status NCT01016431 Phase 4
5 A Randomized Trial of Angiotensin Receptor bLocker,Fimasartan, in Aortic Stenosis (ALFA Trial) Unknown status NCT01589380 Phase 4 Fimasartan;Placebo
6 Sodium Bicarbonate in Cardiopulmonary Resuscitation Unknown status NCT01377337 Phase 4 sodium bicarbonate
7 Out-of Hospital Resuscitation Study Unknown status NCT00196248 Phase 4
8 An Observational Study to Assess the Risk of Out-of-Hospital Sudden Cardiac Death in Users of Domperidone, Users of Proton Pump Inhibitors, and Users of Metoclopramide Completed NCT01907633 Phase 4 No intervention
9 Neuron Specific Enolase (NSE) as Outcome Parameter of Cooling Therapy After Survived Sudden Cardiac Death Completed NCT01102153 Phase 4
10 Protective Effect of EPA on Cardiovascular Events Completed NCT00231738 Phase 4 Eicosapentaenoic acid ethyl ester(EPADEL Capsule 300 TM)
11 'Effect of CRT on Defibrillation Threshold Estimates' Study Completed NCT00626093 Phase 4
12 POWER (Pulse Width Optimized Waveform Evaluation Trial) Completed NCT00311181 Phase 4
13 Long Term Integrity Follow-up Evaluation Completed NCT00848835 Phase 4
14 Predictive Risk Stratification Through T Variability in ICD Patients Without Pacing Indications Completed NCT00560768 Phase 4
15 Survival of Patients With Primary Prophylactic ICD Indication Completed NCT00619593 Phase 4
16 Comparison of Valsartan With Amlodipine in Hypertensive Patients With Glucose Intolerance Completed NCT00129233 Phase 4 Valsartan;Amlodipine
17 The Use of Dual Chamber ICD With Special Programmed Features to Lower the Risk of Inappropriate Shock Completed NCT00787800 Phase 4
18 Effects of Testosterone on Myocardial Repolarization Completed NCT03126656 Phase 4 Testosterone Undecanoate
19 Physiologic Evaluation of Anomalous Right Coronary Artery Stenosis Completed NCT01133054 Phase 4
20 OptiLink HF Study: Optimization of Heart Failure Management Using Medtronic OptiVol Fluid Status Monitoring and CareLink Network Completed NCT00769457 Phase 4
21 Trop-Shock DFT-testing Versus None Completed NCT01230086 Phase 4
22 Study of Qiliqiangxin Capsule to Treat Dilated Cardiomyopathy Completed NCT01293903 Phase 4 Qiliqiangxin capsule;Placebo
23 Carvedilol Post-intervention Long-term Administration in Large-scale Trial Completed NCT01155635 Phase 4 Carvedilol;No Carvedilol
24 COOL-Trial: Outcome With Invasive and Non-invasive Cooling After Cardiac Arrest Completed NCT00843297 Phase 4
25 Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese(MEGA Study) Completed NCT00211705 Phase 4 Diet+pravastatin
26 Multicenter Automatic Defibrillator Implantation Trial - Reduce Inappropriate Therapy Completed NCT00947310 Phase 4
27 Implantable Cardioverter Defibrillator Versus Optimal Medical Therapy In Patients With Variant Angina Manifesting as Aborted Sudden Cardiac Death Recruiting NCT02845531 Phase 4 Optimal Medical Therapy
28 Evaluation of the Entresto Effect on Sympathic Nervous System in Patient With Heart Failure Recruiting NCT02787798 Phase 4 valsartan/sacubitril 100 mg;valsartan/sacubitril 200 mg
29 Prospective Study of End Stage Renal Disease Patients With Coronary Artery Disease Treated by Oral Nicorandil Active, not recruiting NCT01475123 Phase 4 Nicorandil
30 Comparing the Effects of Spironolactone With Chlortalidone on LV Mass in Patients With CKD Active, not recruiting NCT02502981 Phase 4 Spironolactone;Chlortalidone
31 To Determine Optimal Time for Delivering Electrical Shocks to Cardiac Arrest Patients Not yet recruiting NCT01665755 Phase 4
32 CORE: Study to Evaluate the Conducted AF-Response-Algorithm in Patients Suffering From Heart Failure and Atrial Fibrillation Terminated NCT00170313 Phase 4
33 Abrupt Versus Tapered Interruption of Chronic Clopidogrel Therapy After DES Implantation Terminated NCT00640679 Phase 4 Abrupt Clopidogrel Interruption;Clopidogrel Tapering
34 RAMYD Study - Evaluation of Arrhythmic Risk in Myotonic Dystrophy Unknown status NCT00127582 Phase 3
35 DAPERB 3,4-DiAminoPyridine and Electrophysiological Response in Brugada Syndrome Unknown status NCT00701077 Phase 3 3,4-Di-amino-Pyridine;placebo
36 LUCAS Chest Compressor Versus Manual Chest Compression in Out-of-hospital Sudden Cardiac Arrest. LUCAT Trial Unknown status NCT01521208 Phase 3
37 OMEGA-Study: Effect of Omega 3-Fatty Acids on the Reduction of Sudden Cardiac Death After Myocardial Infarction Completed NCT00251134 Phase 3 Zodin (drug);Olive oil (placebo)
38 Effect of Ranolazine on Arrhythmias and Microvolt T- Wave Alternans (MVTWA) Patients With LV Dysfunction Completed NCT00998218 Phase 3 Ranolazine;Placebo
39 Ovatio DR and VR Implantable Cardioverter Defibrillators Post-approval Study Completed NCT00586378 Phase 3
40 Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Completed NCT00000609 Phase 3 amiodarone
41 Coronary Care Caffeine: Influence of Coffee on Heart Rate Post Myocardial Infarction Completed NCT00137098 Phase 3 Caffeine
42 Cardiac Arrhythmia Suppression Trial (CAST) Completed NCT00000526 Phase 3 encainide;flecainide;moricizine
43 Antiarrhythmics Versus Implantable Defibrillators (AVID) Completed NCT00000531 Phase 3 amiodarone amiodarone;sotalol
44 GISSI-HF- Effects of n-3 PUFA and Rosuvastatin on Mortality-Morbidity of Patients With Symptomatic CHF Completed NCT00336336 Phase 3 n-3 PUFA;Rosuvastatin;Placebo;Placebo
45 Vitamin D Supplementation in Chronic Stable Heart Failure Completed NCT01292720 Phase 3 Cholecalciferol;Placebo
46 Psychological Support for Patients With an Implantable Cardioverter Defibrillator Completed NCT00152763 Phase 3
47 Beta-Blocker Heart Attack Trial (BHAT) Completed NCT00000492 Phase 3 propranolol
48 Firefighter Aged Garlic Extract Investigation With CoQ10 as a Treatment for Heart Disease (FAITH) Completed NCT00860847 Phase 3
49 Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (PCI) Completed NCT01442038 Phase 3 Ranolazine;Placebo
50 Effect of High Dose Fish Oil Supplementation After Recent Heart Attack Using Magnetic Resonance Imaging Completed NCT00729430 Phase 3 Omega-3 Fatty Acids (Fish Oil Supplements);Placebo

Search NIH Clinical Center for Sudden Cardiac Death

Genetic Tests for Sudden Cardiac Death

Genetic tests related to Sudden Cardiac Death:

id Genetic test Affiliating Genes
1 Sudden Cardiac Death 29 24

Anatomical Context for Sudden Cardiac Death

MalaCards organs/tissues related to Sudden Cardiac Death:

39
Heart, Testes, Kidney, Bone, Endothelial, Lung, Bone Marrow

Publications for Sudden Cardiac Death

Articles related to Sudden Cardiac Death:

(show top 50) (show all 332)
id Title Authors Year
1
Efficacy of Familial Screening After Sudden Cardiac Death in Young Adults Irrespective of Postmortem Analysis: Implication of a Pharmacological Challenge as a First Step of Screening. ( 28912208 )
2017
2
How to avoid sudden cardiac death. ( 28952797 )
2017
3
Genetic anticipation in a special form of hypertrophic cardiomyopathy with sudden cardiac death in a family with 74 members across 5 generations. ( 28296734 )
2017
4
Aborted Sudden Cardiac Death After Unroofing of Anomalous Left Coronary Artery. ( 28838524 )
2017
5
Sudden Cardiac Death. ( 28938708 )
2017
6
Sudden cardiac death in isolated right ventricular hypertrabeculation/noncompaction cardiomyopathy. ( 28901675 )
2017
7
2016 AHA/ACC Clinical Performance and Quality Measures for Prevention of Sudden Cardiac Death: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures. ( 27993943 )
2017
8
Comments on Letter to the Editor entitled: "Role of electrophysiological evaluation for the best device choice to prevent sudden cardiac death in patients with Myotonic Dystrophy Type1 and Emery Dreifuss Muscular Dystrophy". ( 28291654 )
2017
9
Editorial commentary: QTdrugs: From electrocardiographic intervals to prevention of sudden cardiac death. ( 28882364 )
2017
10
Comparative Risk of Ventricular Arrhythmia and Sudden Cardiac Death Across Antidepressants in Patients With Depressive Disorders. ( 27941418 )
2017
11
Media attention regarding sudden cardiac death associated with domperidone use does not affect in hospital ECG recording. ( 28924989 )
2017
12
Sudden cardiac death among the young in Sweden from 2000 to 2010: an autopsy-based study. ( 28873959 )
2017
13
Age and strain related aberrant Ca(2+) release is associated with sudden cardiac death in the ACTC E99K mouse model of hypertrophic cardiomyopathy. ( 28887330 )
2017
14
Sudden Cardiac Death in Women With Suspected Ischemic Heart Disease, Preserved Ejection Fraction, and No Obstructive Coronary Artery Disease: A Report From the Women's Ischemia Syndrome Evaluation Study. ( 28862961 )
2017
15
Sudden cardiac death in the young: the value of exercise testing. ( 28084955 )
2017
16
Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant. ( 28859293 )
2017
17
Risk stratification of sudden cardiac death in hypertension. ( 28916176 )
2017
18
Role of electrophysiological evaluation for the best device choice to prevent sudden cardiac death in patients with Myotonic Dystrophy Type 1 and Emery Dreifuss Muscular Dystrophy. ( 28237579 )
2017
19
Implantable Cardioverter-Defibrillators in Sudden Cardiac Death Survivors: Are We Doing All We Can? ( 28867264 )
2017
20
Guidelines for autopsy investigation of sudden cardiac death: 2017 update from the Association for European Cardiovascular Pathology. ( 28889247 )
2017
21
Fragmented QRS complex as a predictor of exercise-related sudden cardiac death. ( 28940877 )
2017
22
Sudden Cardiac Death inA Professional Soccer Players. ( 28882241 )
2017
23
Vital exhaustion and sudden cardiac death in the Atherosclerosis Risk in Communities Study. ( 28928241 )
2017
24
Implantable cardioverter-defibrillator therapy among patients with non-ischaemic vs. ischaemic cardiomyopathy for primary prevention of sudden cardiac death. ( 28082419 )
2017
25
Looking forward: PACES Task Force on prevention of sudden cardiac death in the young: a comprehensive approach to a preventable problem. ( 28084975 )
2017
26
Thyroid-stimulating hormone and risk of sudden cardiac death, total mortality and cardiovascular morbidity. ( 28862752 )
2017
27
Can documented coronary vasospasm be the smoking gun in settling the etiology of sudden cardiac death? ( 28870013 )
2017
28
Gender differences in sudden cardiac death in the young-a nationwide study. ( 28061807 )
2017
29
Sudden cardiac death in a dog during Holter recording-R on T phenomenon. ( 28939249 )
2017
30
Inverted U-Shaped Relation Between the Risk of Sudden Cardiac Death and Maximal Left Ventricular Wall Thickness in Hypertrophic Cardiomyopathy. ( 27217341 )
2016
31
Role of risk stratification and genetics in sudden cardiac death. ( 27875062 )
2016
32
Obstructive sleep apnea: Underestimated risk factor in sudden cardiac death in schizophrenia. ( 27656264 )
2016
33
Left ventricular apical hypoplasia: Case report on cardiomyopathy and a history of sudden cardiac death. ( 27114737 )
2016
34
Electrocardiographic predictors of mortality and sudden cardiac death in patients with end stage renal disease on hemodialysis. ( 27554424 )
2016
35
Should the Subcutaneous Implantable Defibrillator Be the First Choice for Primary Prevention of Sudden Cardiac Death? ( 27838348 )
2016
36
Sudden cardiac death: a nationwide cohort study among the young. ( 27910804 )
2016
37
Sudden neurologic death masquerading as out-of-hospital sudden cardiac death. ( 27638923 )
2016
38
Heart adipose tissue and sudden cardiac death in middle-aged men. ( 27085129 )
2016
39
Sudden cardiac death and chronic kidney disease: From pathophysiology to treatment strategies. ( 27174593 )
2016
40
Sudden cardiac death due to deficiency of the mitochondrial inorganic pyrophosphatase PPA2. ( 27523597 )
2016
41
Polymorphisms in the GNAS Gene as Predictors of Ventricular Tachyarrhythmias and Sudden Cardiac Death: Results From the DISCOVERY Trial and Oregon Sudden Unexpected Death Study. ( 27895044 )
2016
42
Sudden cardiac death: A reappraisal. ( 27665048 )
2016
43
Sudden Cardiac Death: Autopsy Findings in 7200 Cases Between 2001 and 2015. ( 27973393 )
2016
44
Value of the QRS-T area angle in improving the prediction of sudden cardiac death after acute coronary syndromes. ( 27203188 )
2016
45
Ventricular fibrillation and sudden cardiac death during myocardial infarction. ( 27127021 )
2016
46
Depression and Risk of Sudden Cardiac Death and Arrhythmias: A Meta-Analysis. ( 27627224 )
2016
47
Sudden cardiac death from structural heart diseases in adults: imaging findings with cardiovascular computed tomography and magnetic resonance. ( 27139460 )
2016
48
CARDIOSTIM-EHRA EUROPACE 2016 included recommendations to prevent sudden cardiac death in athletes. ( 27587477 )
2016
49
Lipoprotein(a) and risk of sudden cardiac death in middle-aged Finnish men: A new prospective cohort study. ( 27393854 )
2016
50
Abiraterone acetate as a possible cause of sudden cardiac death. ( 27569102 )
2016

Variations for Sudden Cardiac Death

ClinVar genetic disease variations for Sudden Cardiac Death:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 PLN NM_002667.4(PLN): c.116T> G (p.Leu39Ter) single nucleotide variant Pathogenic/Likely pathogenic rs111033560 GRCh37 Chromosome 6, 118880200: 118880200
2 DSP NM_004415.3(DSP): c.2528C> A (p.Ser843Ter) single nucleotide variant Pathogenic rs1057518920 GRCh37 Chromosome 6, 7575619: 7575619

Copy number variations for Sudden Cardiac Death from CNVD:

7 (show all 32)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 16658 1 128900000 142600000 Deletion Sudden cardiac death
2 17395 1 142600000 155000000 Deletion S100A1 Sudden cardiac death
3 29860 1 237205701 237997288 Gain RYR2 Sudden cardiac death
4 38181 10 1 6600000 Gain Sudden cardiac death
5 59687 11 77100000 92800000 Deletion KCNA4 Sudden cardiac death
6 73255 12 92600000 120700000 Deletion ATP2A2 Sudden cardiac death
7 74068 13 10000000 16300000 Deletion Sudden cardiac death
8 74687 13 110300000 115169878 Gain Sudden cardiac death
9 77098 13 40100000 45200000 Gain Sudden cardiac death
10 84232 14 24600000 33300000 Deletion TINF2 Sudden cardiac death
11 95625 15 78300000 102531392 Gain Sudden cardiac death
12 101480 16 38600000 52600000 Deletion Sudden cardiac death
13 119791 18 17200000 19000000 Deletion Sudden cardiac death
14 119992 18 19000000 25000000 Deletion Sudden cardiac death
15 124165 19 1 6900000 Gain Sudden cardiac death
16 134550 2 102700000 110200000 Gain Sudden cardiac death
17 138742 2 169700000 183000000 Gain Sudden cardiac death
18 139544 2 183000000 189400000 Gain Sudden cardiac death
19 160068 21 6800000 16400000 Gain Sudden cardiac death
20 166127 3 1 8700000 Deletion ITPR1 Sudden cardiac death
21 166128 3 1 8700000 Gain Sudden cardiac death
22 170551 3 155838336 156256927 Deletion KCNAB1 Sudden cardiac death
23 170851 3 160700000 167600000 Gain TERC Sudden cardiac death
24 191731 5 1 9800000 Gain TERT Sudden cardiac death
25 196534 5 168500000 180915260 Gain Sudden cardiac death
26 208074 6 164500000 171115067 Gain Sudden cardiac death
27 217131 7 1 7300000 Gain Sudden cardiac death
28 218560 7 114600000 117400000 Gain Sudden cardiac death
29 221932 7 147900000 159138663 Gain KCNH2 Sudden cardiac death
30 244984 9 1 9000000 Gain Sudden cardiac death
31 247561 9 130300000 141213431 Gain Sudden cardiac death
32 254437 9 65900000 68700000 Deletion gain CMD1B Sudden cardiac death

Expression for Sudden Cardiac Death

Search GEO for disease gene expression data for Sudden Cardiac Death.

Pathways for Sudden Cardiac Death

Pathways related to Sudden Cardiac Death according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.46 KCNE1 KCNJ2 KCNJ5 KCNQ1 MYH7 SCN5A
2
Show member pathways
12.23 KCNE1 KCNH2 KCNJ2 KCNQ1 MYBPC3 SCN5A
3 12.01 KCNE1 KCNH2 KCNJ2 KCNJ5 KCNQ1
4
Show member pathways
11.84 KCNH2 KCNJ2 KCNJ5 KCNQ1
5 11.82 KCNH2 KCNQ1 SCN5A
6
Show member pathways
11.46 KCNE1 KCNQ1 SCN5A
7 10.97 ANK2 DSP KCNE1 KCNH2 KCNJ2 KCNJ5
8 10.93 ANK2 SCN5A
9 10.78 KCNE1 KCNJ2 KCNQ1

GO Terms for Sudden Cardiac Death

Cellular components related to Sudden Cardiac Death according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.67 ANK2 KCNE1 KCNQ1
2 basolateral plasma membrane GO:0016323 9.65 ANK2 DSP KCNQ1
3 intercalated disc GO:0014704 9.56 ANK2 DSP KCNJ2 SCN5A
4 myofibril GO:0030016 9.51 MYH7 TPM1
5 sarcomere GO:0030017 9.5 MYBPC3 MYH7 TPM1
6 M band GO:0031430 9.46 ANK2 MYBPC3
7 T-tubule GO:0030315 9.46 ANK2 KCNJ2 KCNJ5 SCN5A
8 myosin filament GO:0032982 9.4 MYBPC3 MYH7
9 A band GO:0031672 9.37 ANK2 MYBPC3
10 Z disc GO:0030018 9.35 ANK2 KCNE1 MYBPC3 MYH7 SCN5A
11 voltage-gated potassium channel complex GO:0008076 9.02 KCNE1 KCNH2 KCNJ2 KCNJ5 KCNQ1
12 plasma membrane GO:0005886 10.09 AKAP10 ANK2 DSP KCNE1 KCNH2 KCNJ2

Biological processes related to Sudden Cardiac Death according to GeneCards Suite gene sharing:

(show all 36)
id Name GO ID Score Top Affiliating Genes
1 regulation of ion transmembrane transport GO:0034765 9.95 KCNE1 KCNH2 KCNJ2 KCNJ5 KCNQ1 SCN5A
2 potassium ion transmembrane transport GO:0071805 9.9 KCNE1 KCNH2 KCNJ2 KCNQ1
3 potassium ion transport GO:0006813 9.89 KCNE1 KCNH2 KCNJ2 KCNJ5 KCNQ1
4 cardiac conduction GO:0061337 9.83 KCNE1 KCNH2 KCNJ2 KCNQ1 SCN5A
5 muscle filament sliding GO:0030049 9.78 MYBPC3 MYH7 TPM1
6 regulation of heart rate GO:0002027 9.77 ANK2 MYH7 SCN5A
7 positive regulation of potassium ion transmembrane transport GO:1901381 9.76 KCNE1 KCNH2 KCNJ2 KCNQ1
8 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.75 MYBPC3 MYH7 TPM1
9 cardiac muscle cell action potential involved in contraction GO:0086002 9.74 KCNE1 KCNJ2 SCN5A
10 regulation of cardiac muscle cell contraction GO:0086004 9.73 ANK2 KCNJ2 SCN5A
11 regulation of membrane repolarization GO:0060306 9.72 KCNH2 KCNJ2 KCNQ1
12 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.71 KCNE1 KCNH2 KCNJ2 KCNQ1
13 atrial cardiac muscle cell action potential GO:0086014 9.7 ANK2 KCNQ1 SCN5A
14 potassium ion export GO:0071435 9.69 KCNE1 KCNH2 KCNQ1
15 sarcomere organization GO:0045214 9.67 MYBPC3 TPM1
16 positive regulation of ATPase activity GO:0032781 9.67 MYBPC3 TPM1
17 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.67 KCNE1 KCNH2 KCNJ5 KCNQ1
18 regulation of heart contraction GO:0008016 9.66 KCNQ1 TPM1
19 membrane depolarization during action potential GO:0086010 9.65 KCNH2 SCN5A
20 striated muscle contraction GO:0006941 9.65 MYBPC3 MYH7
21 potassium ion import GO:0010107 9.65 KCNJ2 KCNJ5
22 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.65 ANK2 KCNE1 KCNH2 KCNQ1 SCN5A
23 regulation of potassium ion transmembrane transport GO:1901379 9.64 KCNE1 KCNH2
24 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.64 KCNJ2 SCN5A
25 SA node cell action potential GO:0086015 9.63 ANK2 SCN5A
26 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.63 KCNQ1 SCN5A
27 membrane depolarization during SA node cell action potential GO:0086046 9.62 ANK2 SCN5A
28 membrane repolarization during atrial cardiac muscle cell action potential GO:0098914 9.62 KCNJ5 KCNQ1
29 membrane repolarization during action potential GO:0086011 9.62 KCNE1 KCNH2 KCNJ2 KCNQ1
30 potassium ion export across plasma membrane GO:0097623 9.61 KCNH2 KCNQ1
31 ventricular cardiac muscle cell action potential GO:0086005 9.55 ANK2 KCNE1 KCNH2 KCNQ1 SCN5A
32 membrane repolarization GO:0086009 9.54 KCNE1 KCNQ1
33 cardiac muscle contraction GO:0060048 9.43 KCNH2 KCNQ1 MYBPC3 MYH7 SCN5A TPM1
34 regulation of heart rate by cardiac conduction GO:0086091 9.23 ANK2 DSP KCNE1 KCNH2 KCNJ2 KCNJ5
35 transport GO:0006810 10.14 KCNE1 KCNH2 KCNJ2 KCNJ5 KCNQ1 SCN5A
36 ion transport GO:0006811 10.06 KCNE1 KCNH2 KCNJ2 KCNJ5 KCNQ1 SCN5A

Molecular functions related to Sudden Cardiac Death according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.7 KCNQ1 MYH7 SCN5A
2 ion channel binding GO:0044325 9.69 ANK2 KCNQ1 SCN5A
3 structural constituent of cytoskeleton GO:0005200 9.67 ANK2 DSP TPM1
4 potassium channel activity GO:0005267 9.63 KCNE1 KCNH2 KCNQ1
5 voltage-gated potassium channel activity GO:0005249 9.61 KCNE1 KCNH2 KCNQ1
6 scaffold protein binding GO:0097110 9.56 DSP KCNH2 KCNQ1 SCN5A
7 voltage-gated ion channel activity GO:0005244 9.55 KCNH2 KCNJ2 KCNJ5 KCNQ1 SCN5A
8 structural constituent of muscle GO:0008307 9.54 MYBPC3 TPM1
9 delayed rectifier potassium channel activity GO:0005251 9.54 KCNE1 KCNH2 KCNQ1
10 inward rectifier potassium channel activity GO:0005242 9.5 KCNH2 KCNJ2 KCNJ5
11 G-protein activated inward rectifier potassium channel activity GO:0015467 9.48 KCNJ2 KCNJ5
12 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization GO:0086089 9.4 KCNJ5 KCNQ1
13 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 9.26 KCNE1 KCNH2 KCNJ5 KCNQ1
14 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 8.92 KCNE1 KCNH2 KCNJ2 KCNQ1

Sources for Sudden Cardiac Death

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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