SIDS
MCID: SDD001
MIFTS: 71

Sudden Infant Death Syndrome (SIDS) malady

Genetic diseases, Rare diseases categories

Summaries for Sudden Infant Death Syndrome

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9Disease Ontology, 35MedlinePlus, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 Sudden infant death syndrome (sids) is the sudden, unexplained death of an infant younger than one year old. some people call sids "crib death" because many babies who die of sids are found in their cribs. sids is the leading cause of death in children between one month and one year old. most sids deaths occur when babies are between two months and four months old. premature babies, boys, african americans, and american indian/alaska native infants have a higher risk of sids. although health care professionals don't know what causes sids, they do know ways to reduce the risk. these include placing babies on their backs to sleep, even for short naps. "tummy time" is for when babies are awake and someone is watching using a firm sleep surface, such as a crib mattress covered with a fitted sheet keeping soft objects and loose bedding away from sleep area making sure babies don't get too hot. keep the room at a comfortable temperature for an adult. nih: national institute of child health and human development

MalaCards: Sudden Infant Death Syndrome, also known as sudden infant death syndrome, susceptibility to, is related to long qt syndrome and medium-chain acyl-coenzyme a dehydrogenase deficiency. An important gene associated with Sudden Infant Death Syndrome is SCN5A (sodium channel, voltage-gated, type V, alpha subunit), and among its related pathways are Antiarrhythmic Pathway, Pharmacodynamics and Potassium Channels. The compounds cocaethylene and flecainide have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and breast, and related mouse phenotypes are muscle and normal.

Disease Ontology:9 A syndrome that is characterized by the sudden death of an infant that is not predicted by medical history and remains unexplained after a thorough forensic autopsy and detailed death scene investigation.

Wikipedia:66 Sudden infant death syndrome (SIDS) also known as cot death or crib death is the sudden death of an... more...

Description from OMIM:48 272120

Aliases & Classifications for Sudden Infant Death Syndrome

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9Disease Ontology, 10diseasecard, 44NIH Rare Diseases, 23GTR, 48OMIM, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases


Aliases & Descriptions:

sudden infant death syndrome 9 44 48 11 46 35 63
sudden infant death syndrome, susceptibility to 10 23
sids 9 44
sudden death of nonspecific cause in infancy 9
sudden infant death syndrome nos 9
crib death 9
cot death 9


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Disease Ontology9 DOID:9007
NCIt41 C85173
MeSH36 D013398
OMIM48 272120
ICD9CM28 798.0

Related Diseases for Sudden Infant Death Syndrome

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18GeneCards, 19GeneDecks
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Diseases in the Sudden Infant Death Syndrome family:

Cav3-Related Sudden Infant Death Syndrome

Diseases related to Sudden Infant Death Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1long qt syndrome31.2CAV3, SNTA1, SCN5A, KCNH2
2medium-chain acyl-coenzyme a dehydrogenase deficiency30.4ACADS, ACADM
3ischemia30.2TH, KCNJ8, SCN5A, G6PC, ADCYAP1
4brugada syndrome30.1KCNH2, GPD1L, SCN5A
5neuronitis10.7
6hypoxia10.7
7infant botulism10.5
8botulism10.5
9congenital central hypoventilation syndrome10.5
10central hypoventilation syndrome10.5
11cerebritis10.4
12laryngitis10.4
13cav3-related sudden infant death syndrome10.4
14hypophosphatemia10.3
15toxic shock syndrome10.3
16reye syndrome10.3
17myocarditis10.3
18pneumonia10.3
19hyperekplexia10.3
20bronchiolitis10.2
21desquamative interstitial pneumonia10.2
22munchausen by proxy10.2
23nasopharyngitis10.2
24hypertrophic pyloric stenosis10.2
25hypohidrotic ectodermal dysplasia10.2
26fetal alcohol syndrome10.2
27short qt syndrome10.2
28asthma10.2
29embryonal rhabdomyosarcoma10.2
30eosinophilia10.2
31hepatitis10.2
32influenza10.2
33intellectual disability10.2
34legionellosis10.2
35mediastinitis10.2
36meningitis10.2
37opiate dependence10.2
38prostatitis10.2
39pulmonary eosinophilia10.2
40pyloric stenosis10.2
41rhabdomyosarcoma10.2
42sleep apnea10.2
43ectodermal dysplasia10.2
44infantile apnea10.2
45infantile histiocytoid cardiomyopathy10.2
46plagiocephaly10.2
47staphylococcal toxic shock syndrome10.2
48fatty acid oxidation disorders10.2
49cerebral hypoxia10.2
50megalencephaly10.2

Graphical network of the top 20 diseases related to Sudden Infant Death Syndrome:



Diseases related to sudden infant death syndrome

Symptoms for Sudden Infant Death Syndrome

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48OMIM
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Symptoms by clinical synopsis from OMIM:

272120

Clinical features from OMIM:

272120

Drugs & Therapeutics for Sudden Infant Death Syndrome

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Sudden Infant Death Syndrome

Drug clinical trials:

Search ClinicalTrials for Sudden Infant Death Syndrome

Search NIH Clinical Center for Sudden Infant Death Syndrome

Search CenterWatch for Sudden Infant Death Syndrome

Genetic Tests for Sudden Infant Death Syndrome

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23GTR
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Genetic tests related to Sudden Infant Death Syndrome:

id Genetic test Affiliating Genes
1 Sudden Infant Death Syndrome23

Anatomical Context for Sudden Infant Death Syndrome

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34MalaCards
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MalaCards organs/tissues related to Sudden Infant Death Syndrome:

34
Brain, Heart, Breast, Lung, Liver, Testes, Hypothalamus, Prostate, Endothelial, Pituitary, Placenta, Colon, Smooth muscle, Whole blood, Eye, Medulla oblongata

Animal Models for Sudden Infant Death Syndrome or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Sudden Infant Death Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5KCNH2, SCN5A, ADCYAP1, SNTA1, CAV3, SLC6A4
2MP:00028738.4PHOX2B, SLC6A4, TH, SCN5A, G6PC, EN1
3MP:00053708.2TH, C4B, ACADM, ACADS, ADCYAP1, G6PC
4MP:00053857.6ACADM, C4B, PHOX2B, SLC6A4, TH, KCNH2
5MP:00036317.5SLC6A4, SCN5A, TH, G6PC, ADCYAP1, SNTA1
6MP:00053847.4TH, PHOX2B, EN1, CAV3, ACADS, ADCYAP1
7MP:00053787.3EN1, G6PC, SCN5A, IDS, KCNH2, ADCYAP1
8MP:00053867.3SCN5A, SLC6A4, EN1, SNTA1, ACADS, ADCYAP1
9MP:00053766.6G6PC, ADCYAP1, SNTA1, ACADS, ACADM, CAV3
10MP:00107686.5C4B, TH, KCNH2, KCNJ8, IDS, SCN5A

Publications for Sudden Infant Death Syndrome

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53PubMed
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Articles related to Sudden Infant Death Syndrome:

(show top 50)    (show all 563)
idTitleAuthorsYear
1
Sudden Infant Death Syndrome (SIDS) risk reduction and infant sleep location - moving the discussion forward. (22571891)
2013
2
Functional single-nucleotide variant of HSPD1 in sudden infant death syndrome. (23823174)
2013
3
Sudden infant death syndrome: cry characteristics. (23759336)
2013
4
A re-audit of the use of definitions of sudden infant death syndrome (SIDS) in peer-reviewed literature. (23084308)
2012
5
Temporal trends in sudden infant death syndrome in Canada from 1991 to 2005: contribution of changes in cause of death assignment practices and in maternal and infant characteristics. (22324498)
2012
6
Review finds that bed sharing increases risk of sudden infant death syndrome. (22561148)
2012
7
Do infants die of sudden infant death syndrome (SIDS) with long QT syndrome (LQTS) or from LQTS? (22868671)
2012
8
Reanalyses of case-control studies examining the temporal association between sudden infant death syndrome and vaccination. (22289512)
2012
9
Cardiac ion channelopathies and the sudden infant death syndrome. (23304551)
2012
10
Prenatal nicotine exposure in rhesus monkeys compromises development of brainstem and cardiac monoamine pathways involved in perinatal adaptation and sudden infant death syndrome: amelioration by vitamin C. (21320590)
2011
11
Formative evaluation to improve prevention of sudden infant death syndrome (SIDS): a prospective study. (21517963)
2011
12
Serotonin in the sudden infant death syndrome. (21152449)
2010
13
Cardiac muscarinic receptor overexpression in sudden infant death syndrome. (20209124)
2010
14
Outcomes of heart transplantation using donor hearts from infants with sudden infant death syndrome. (20691612)
2010
15
Association of dopamine transporter and monoamine oxidase molecular polymorphisms with sudden infant death syndrome and stillbirth: new insights into the serotonin hypothesis. (18810510)
2009
16
The role of infection and inflammation in sudden infant death syndrome. (19874217)
2009
17
Sudden infant death syndrome (SIDS) in African Americans: polymorphisms in the gene encoding the stress peptide pituitary adenylate cyclase-activating polypeptide (PACAP). (19120039)
2009
18
Minimizing the risks of sudden infant death syndrome: to swaddle or not to swaddle? (19540517)
2009
19
Sudden infant death syndrome: a developmental psychobiologist's perspective. (19206137)
2009
20
Genes regulating the serotonin metabolic pathway in the brain stem and their role in the etiopathogenesis of the sudden infant death syndrome. (18387780)
2008
21
Sleep position alters arousal processes maximally at the high-risk age for sudden infant death syndrome. (19090953)
2008
22
The effect of maternal smoking and drinking during pregnancy upon (3)H-nicotine receptor brainstem binding in infants dying of the sudden infant death syndrome: initial observations in a high risk population. (17924983)
2008
23
Intrathoracic petechial hemorrhages in sudden infant death syndrome and other infant deaths: time for re-examination. (18416633)
2008
24
Cytomegalovirus-induced pneumonia and myocarditis in three cases of suspected sudden infant death syndrome (SIDS): diagnosis by immunohistochemical techniques and molecularpathologic methods. (17566679)
2008
25
Sudden infant death syndrome and activating GNAS1 gene mutations. (18075835)
2007
26
Cribs for Kids: risk and reduction of sudden infant death syndrome and accidental suffocation. (17896680)
2007
27
Letter by O'Rourke regarding articles, "Prevalence of long-QT syndrome gene variants in sudden infant death syndrome," "Cardiac sodium channel dysfunction in sudden infant death syndrome," and "Contribution of long-QT syndrome genes to sudden infant death syndrome: is it time to consider newborn electrocardiographic screening?". (17646591)
2007
28
Hemoglobin F in sudden infant death syndrome: a San Diego SIDS/SUDC Research Project report. (17961870)
2007
29
Mechanisms of pathogenesis in the Sudden Infant Death Syndrome. (17644048)
2007
30
Sudden infant death syndrome. (17452672)
2007
31
Educating parents about the risk factors of sudden infant death syndrome: the role of neonatal intensive care unit and well baby nursery nurses. (17505237)
2007
32
Contribution of long-QT syndrome genes to sudden infant death syndrome: is it time to consider newborn electrocardiographic screening? (17242294)
2007
33
Sudden infant death syndrome. (17980736)
2007
34
Recent research in sudden infant death syndrome. (17990653)
2007
35
Predicting the risk of sudden infant death syndrome from obstetric characteristics. (16396879)
2006
36
New recommendations to reduce the risk of sudden infant death syndrome. (16523040)
2006
37
Effects of prematurity on heart rate control: implications for sudden infant death syndrome. (16716094)
2006
38
Sudden Infant Death Syndrome and prenatal maternal smoking: rising attributed risk in the Back to Sleep era. (15644131)
2005
39
Fatty acid oxidation disorder as a cause of sudden infant death syndrome (SIDS)--a case report. (16366103)
2005
40
Sudden Infant Death Syndrome: increased carotid-body dopamine and noradrenaline content. (16034653)
2005
41
Mortality due to sudden infant death syndrome in Northern Italy, 1990-2000: a baseline for the assessment of prevention campaigns. (15367320)
2004
42
Genes and Sudden Infant Death Syndrome. (15240865)
2004
43
Possible pathomechanisms of sudden infant death syndrome: key role of chronic hypoxia, infection/inflammation states, cytokine irregularities, and metabolic trauma in genetically predisposed infants. (15543094)
2004
44
Adult hemoglobin levels at birth and risk of sudden infant death syndrome. (15066877)
2004
45
Sudden infant death syndrome is not associated with the mutation of PHOX2B gene, a major causative gene of congenital central hypoventilation syndrome. (15185974)
2004
46
Transcutaneous implantation of an internal cardioverter defibrillator in a small infant with recurrent myocardial ischemia and cardiac arrest simulating sudden infant death syndrome. (14720167)
2004
47
Prenatal nicotine exposure alters central cardiorespiratory responses to hypoxia in rats: implications for sudden infant death syndrome. (15496661)
2004
48
Sudden infant death syndrome: is it a transepithelial transport disorder? (12323127)
2002
49
Frequency of 985A-to-G mutation in medium-chain acyl-CoA dehydrogenase gene among patients with sudden infant death syndrome, Reye syndrome, severe motor and intellectual disabilities and healthy newborns in Japan. (8840534)
1996
50
Desquamative interstitial pneumonia in an infant. Mimicry of sudden infant death syndrome. (2589300)
1989

Variations for Sudden Infant Death Syndrome

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65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Sudden Infant Death Syndrome:

65 (show all 11)
id Symbol AA change Variation ID SNP ID
1CAV3p.Val14LeuVAR_043694rs121909281
2CAV3p.Thr78MetVAR_043695rs72546668
3CAV3p.Leu79ArgVAR_043696
4GPD1Lp.Glu83LysVAR_044044
5GPD1Lp.Ile124ValVAR_044045rs72552293
6GPD1Lp.Arg273CysVAR_044046
7KCNJ8p.Val346IleVAR_065879
8SCN5Ap.Ser1333TyrVAR_036666
9SCN5Ap.Phe532CysVAR_055177
10SCN5Ap.Gly1084SerVAR_055185
11SCN5Ap.Phe1705SerVAR_055207

Clinvar genetic disease variations for Sudden Infant Death Syndrome:

1 (show all 17)
id Gene Name Type Significance SNP ID Assembly Location
1KCNQ1NM_000218.2(KCNQ1): c.1135T> C (p.Trp379Arg)single nucleotide variantPathogenicrs199472768GRCh37Chr 11, 2608806: 2608806
2KCNQ1NM_000218.2(KCNQ1): c.1750G> A (p.Gly584Ser)single nucleotide variantPathogenicrs199472811GRCh37Chr 11, 2799223: 2799223
3KCNQ1NM_000218.2(KCNQ1): c.1793A> G (p.Lys598Arg)single nucleotide variantPathogenicrs199472817GRCh37Chr 11, 2799266: 2799266
4KCNH2NM_000238.3(KCNH2): c.2684C> T (p.Thr895Met)single nucleotide variantPathogenicrs199473434GRCh37Chr 7, 150645540: 150645540
5KCNH2NM_000238.3(KCNH2): c.2860C> T (p.Arg954Cys)single nucleotide variantPathogenicrs141401803GRCh37Chr 7, 150644799: 150644799
6KCNH2NM_000238.3(KCNH2): c.3118A> G (p.Ser1040Gly)single nucleotide variantPathogenicrs199473024GRCh37Chr 7, 150644450: 150644450
7KCNH2NM_000238.3(KCNH2): c.818G> A (p.Arg273Gln)single nucleotide variantPathogenicrs199472877GRCh37Chr 7, 150655245: 150655245
8KCNH2NM_000238.3(KCNH2): c.835G> A (p.Val279Met)single nucleotide variantPathogenicrs199472879GRCh37Chr 7, 150655228: 150655228
9SCN5ANM_000335.4(SCN5A): c.2039G> A (p.Arg680His)single nucleotide variantPathogenicrs199473142GRCh37Chr 3, 38639443: 38639443
10SCN5ANM_000335.4(SCN5A): c.3247G> A (p.Gly1083Ser)single nucleotide variantPathogenicrs199473190GRCh37Chr 3, 38620965: 38620965
11SCN5ANM_000335.4(SCN5A): c.4453T> C (p.Phe1485Leu)single nucleotide variantPathogenicrs199473615GRCh37Chr 3, 38597233: 38597233
12SCN5ANM_000335.4(SCN5A): c.5111T> C (p.Phe1704Ser)single nucleotide variantPathogenicrs199473627GRCh37Chr 3, 38592749: 38592749
13GPD1LNM_015141.3(GPD1L): c.370A> G (p.Ile124Val)single nucleotide variantLikely pathogenic, Pathogenicrs72552293GRCh37Chr 3, 32181723: 32181723
14SCN5ANM_000335.4(SCN5A): c.3305C> A (p.Ser1102Tyr)single nucleotide variantBenign, Pathogenic, risk factorrs7626962GRCh37Chr 3, 38620907: 38620907
15MT-TL1m.3290T> Csingle nucleotide variantPathogenicrs199474665GRCh37Chr MT, 3290: 3290
16MT-ND1m.3308T> Csingle nucleotide variantPathogenicrs28358582GRCh37Chr MT, 3308: 3308
17MT-ND1m.3308T> Gsingle nucleotide variantPathogenicrs28358582GRCh37Chr MT, 3308: 3308

Expression for genes affiliated with Sudden Infant Death Syndrome

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sudden Infant Death Syndrome

Search GEO for disease gene expression data for Sudden Infant Death Syndrome.

Pathways for genes affiliated with Sudden Infant Death Syndrome

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Sources:
51PathCards, 52PharmGKB, 56Reactome, 13EMD Millipore, 31KEGG, 39NCBI BioSystems Database, 61Thomson Reuters
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Pathways related to Sudden Infant Death Syndrome according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8KCNJ8, SCN5A, KCNH2
2
Show member pathways
9.8KCNH2, SLC6A4, KCNJ8
3
Show member pathways
phenylethylamine degradation I39
9.4ACADM, ECHS1
4
Show member pathways
9.4ECHS1, ACADM
5
Show member pathways
9.3ACADS, ECHS1
6
Show member pathways
L-serine degradation39
pentose phosphate pathway (oxidative branch)39
formaldehyde oxidation II (glutathione-dependent)39
9.1ACADS, ECHS1, ACADM
7
Show member pathways
mitochondrial L-carnitine shuttle pathway39
Saturated fatty acid biosynthesis61
9.1ECHS1, ACADM, ACADS
8
Show member pathways
beta-alanine degradation I39
valine degradation I39
pyruvate fermentation to lactate39
isoleucine degradation I39
9.1ECHS1, ACADS, ACADM
9
Show member pathways
fatty acid beta-oxidation III (unsaturated, odd number)39
Fatty Acid Beta Oxidation39
8.7SLC25A20, ACADM, ACADS, ECHS1
10
Show member pathways
8.5ACADS, GPD1L, SLC25A20, ACADM, ECHS1
11
Show member pathways
7.4IDS, ACADS, ACADM, SLC25A20, GPD1L, TH
125.6TSPYL1, GPD1L, SCN5A, G6PC, C4B, C4A

Compounds for genes affiliated with Sudden Infant Death Syndrome

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46Novoseek, 52PharmGKB, 30IUPHAR, 12DrugBank, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Sudden Infant Death Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1cocaethylene4610.4SLC6A4, KCNH2
2flecainide52 46 30 1213.4SCN5A, KCNH2
3propafenone30 46 52 1213.4KCNH2, SCN5A
4mexiletine52 46 1212.4SCN5A, KCNH2
5trazodone46 30 1212.2KCNH2, SLC6A4
6FADH2510.2ACADM, ACADS
7mazindol46 30 1212.2SLC6A4, TH
8d amphetamine4610.1TH, SLC6A4
9pentamidine46 1211.1KCNH2, G6PC
10mdma4610.0TH, SLC6A4
115-hydroxytryptophan469.9SLC6A4, TH
12carnitine469.9SLC25A20, ACADM, ACADS
13acyl-coa469.8SLC25A20, ACADM, ACADS
14mhpg469.8SLC6A4, TH
15sodium46 2510.8KCNH2, SCN5A, SNTA1, CAV3, SLC6A4
16methylphenidate46 52 1211.7TH, SLC6A4
17tetrodotoxin46 62 3011.7TH, SCN5A, ADCYAP1
18verapamil46 30 52 25 1213.7SLC6A4, SCN5A, KCNH2, TH
19cocaine46 1210.7TH, KCNH2, SCN5A, SLC6A4
203-methylcrotonyl-coa46 2510.6ECHS1, ACADM
21corticosterone46 62 2511.6SLC6A4, ADCYAP1, TH
22potassium46 25 1211.6ADCYAP1, SCN5A, KCNJ8, KCNH2
23Tiglyl-CoA259.5ECHS1, ACADS, ACADM
24Methacrylyl-CoA259.5ECHS1, ACADS, ACADM
25nimodipine46 30 1211.5ADCYAP1, TH
26haloperidol46 52 30 3 1213.4TH, KCNH2, ADCYAP1, SLC6A4
27maoa469.4SLC6A4, TH
28Acrylyl-CoA259.4ACADS, ACADM, ECHS1
29(2E)-Tetradecenoyl-CoA259.4ECHS1, ACADS, ACADM
30Crotonoyl-CoA259.4ACADM, ACADS, ECHS1
31trans-2-Hexenoyl-CoA259.4ACADM, ACADS, ECHS1
32norepinephrine46 25 1211.4TH, ADCYAP1, PHOX2B, SLC6A4
33(2E)-Octenoyl-CoA259.4ECHS1, ACADM, ACADS
34(2E)-Decenoyl-CoA259.4ACADM, ACADS, ECHS1
35glutamine469.4TH, SCN5A, G6PC, ACADM, PHOX2B
36s-adenosylmethionine46 25 1211.4SLC25A20, ACADM, ACADS
37(2E)-Dodecenoyl-CoA259.4ACADM, ACADS, ECHS1
38(2E)-Hexadecenoyl-CoA259.4ECHS1, ACADS, ACADM
39Heptanoyl-CoA259.3ACADM, ACADS, ECHS1
40aspartate469.2TH, SCN5A, G6PC, ADCYAP1, SLC6A4
41alanine469.1TH, KCNH2, SCN5A, G6PC, PHOX2B, SLC6A4
42threonine469.0KCNH2, SCN5A, ADCYAP1, C4A, C4B
43lipid469.0KCNH2, G6PC, ACADS, ACADM, CAV3, SLC25A20
44steroid468.9KCNH2, IDS, G6PC, ADCYAP1, C4A, C4B
45glutamate468.8TH, G6PC, ADCYAP1, ACADS, ACADM, SLC6A4
46oxygen46 259.7TH, KCNH2, G6PC, ADCYAP1, ACADM, C4A
47serine468.7KCNH2, SCN5A, ADCYAP1, ACADS, SLC6A4, C4A
48calcium46 52 25 1211.6KCNH2, IDS, SCN5A, G6PC, ADCYAP1, SNTA1
49arginine468.5KCNH2, SCN5A, G6PC, ADCYAP1, ACADM, SLC6A4
50fatty acid468.1SLC25A20, ECHS1, G6PC, ADCYAP1, ACADS, ACADM

GO Terms for genes affiliated with Sudden Infant Death Syndrome

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17Gene Ontology
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Cellular components related to Sudden Infant Death Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sarcolemmaGO:0423839.4KCNJ8, SCN5A, SNTA1, CAV3
2mitochondrionGO:0057397.9TH, ECHS1, KCNJ8, ACADS, ACADM, SLC25A20

Biological processes related to Sudden Infant Death Syndrome according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1regulation of sodium ion transmembrane transportGO:190230510.3SCN5A, SNTA1
2membrane depolarization during action potentialGO:08601010.3SCN5A, KCNH2
3negative regulation of potassium ion transmembrane transportGO:190138010.2CAV3, KCNH2
4regulation of ventricular cardiac muscle cell membrane depolarizationGO:06037310.2CAV3, SCN5A, GPD1L
5regulation of sodium ion transmembrane transporter activityGO:200064910.2CAV3, GPD1L
6brainstem developmentGO:00336010.2SCN5A, PHOX2B
7positive regulation of sodium ion transportGO:01076510.2SCN5A, GPD1L
8fatty acid beta-oxidation using acyl-CoA dehydrogenaseGO:03353910.1ACADM, ACADS
9regulation of heart rate by cardiac conductionGO:08609110.0KCNH2, SCN5A
10regulation of heart rateGO:00202710.0GPD1L, SCN5A, SNTA1, CAV3
11regulation of ventricular cardiac muscle cell membrane repolarizationGO:0603079.9KCNH2, SCN5A, SNTA1, CAV3
12regulation of heart contractionGO:0080169.8CAV3, TH
13ventricular cardiac muscle cell action potentialGO:0860059.7CAV3, SNTA1, SCN5A, GPD1L, KCNH2
14response to starvationGO:0425949.7ACADM, ACADS, ADCYAP1
15regulation of complement activationGO:0304499.5C4B, C4A
16fatty acid beta-oxidationGO:0066359.3ECHS1, ACADS, ACADM
17pigmentationGO:0434739.2TH, EN1
18cellular lipid metabolic processGO:0442558.8ECHS1, GPD1L, ACADS, ACADM, SLC25A20
19small molecule metabolic processGO:0442817.7TH, ECHS1, GPD1L, IDS, G6PC, ACADS

Molecular functions related to Sudden Infant Death Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inward rectifier potassium channel activityGO:00524210.0KCNJ8, KCNH2
2sodium channel regulator activityGO:0170809.8CAV3, SNTA1, GPD1L
3nitric-oxide synthase bindingGO:0509989.7SLC6A4, CAV3, SNTA1, SCN5A
4ion channel bindingGO:0443259.7GPD1L, SCN5A, SNTA1, CAV3
5acyl-CoA dehydrogenase activityGO:0039959.6ACADM, ACADS

Products for genes affiliated with Sudden Infant Death Syndrome

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Sources for Sudden Infant Death Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet