Sudden Infant Death Syndrome malady

MedlinePlus: Sudden infant death syndrome (sids) is the sudden, unexplained death of an infant younger than one year old. some people call sids "crib death" because many babies who die of sids are found in their cribs. sids is the leading cause of death in children between one month and one year old. most sids deaths occur when babies are between two months and four months old. although health care professionals don't know what causes sids, they do know ways to reduce the risk. these include placing babies on their backs to sleep, even for short naps - "tummy time" is for when babies are awake and someone is watching using a firm sleep surface, such as a crib mattress covered with a fitted sheet keeping soft objects and loose bedding away from sleep area making sure babies don't get too hot - keep the room at a comfortable temperature for an adult nih: national institute of child health and human development²³

MalaCards: Sudden Infant Death Syndrome, also known as sids, is related to sudden cardiac death multi-gene panels and reye syndrome. An important gene associated with Sudden Infant Death Syndrome is SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4), and among its related pathways are Fatty acid metabolism and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The compounds mdma and nicotine have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and liver, and related mouse phenotypes are hematopoietic system and respiratory system.

Genetics Home Reference: Hereditary hyperekplexia is a condition in which affected infants have increased muscle tone (hypertonia) and an exaggerated startle reaction to unexpected stimuli, especially loud noises. Following the startle reaction, infants experience a brief period in which they are very rigid and unable to move. During these rigid periods, some infants stop breathing, which, if prolonged, can be fatal. This condition may explain some cases of sudden infant death syndrome (SIDS), which is a major cause of unexplained death in babies younger than 1 year. Infants with hereditary hyperekplexia have hypertonia at all times, except when they are sleeping.¹⁷

CDC: Sudden unexpected infant deaths are defined as deaths in infants less than 1 year of age that occur suddenly and unexpectedly, and whose cause of death are not immediately obvious prior to investigation.²

Wikipedia: Sudden Infant Death Syndrome (SIDS) is marked by the sudden death of an infant that is not predicted by...⁴⁴ more...

OMIM: 272120

Aliases & Descriptions:

sudden infant death syndrome 6 30 8 33 32 23 43 sids 6 30 sudden infant death syndrome nos (context-dependent category) 6 sudden infant death syndrome (context-dependent category) 6 sudden death of nonspecific cause in infancy 6 crib death (context-dependent category) 6

cot death (context-dependent category) 6 sudden infant death syndrome (finding) 6 sudden cardiac death 43 cot death 6

Diseases related to sudden infant death syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 785)

id	Related Disease	Score	Top Affiliating Genes
1	sudden cardiac death multi-gene panels	33.0	KCNE1, KCNH2, KCNJ2, KCNQ1, KCNE2, SCN5A
2	reye syndrome	32.8	IFNG, ACADM, SLC22A5, HADHA
3	long qt syndrome	32.7	KCNE1, KCNH2, KCNJ2, KCNQ1, KCND3, KCNE2
4	brugada syndrome	32.6	KCNE1, KCNH2, KCNJ2, KCNQ1, SCN5A, RYR2
5	medium-chain acyl-coenzyme a dehydrogenase deficiency	32.0	ACADS, ACADL, ACADM, ACADVL, HADHA
6	congenital central hypoventilation syndrome	31.7	RET, ASCL1, PHOX2B, TH
7	central hypoventilation syndrome	31.5	RET, ASCL1, GRP, EN1, PHOX2A, PHOX2B
8	catecholaminergic polymorphic ventricular tachycardia	30.6	KCNH2, KCNJ2, KCNE2, SCN5A, HTR3A, ACADVL
9	gliosis	30.5	SCN1B, CHAT, FOS, IL6, MAOB, IFNG
10	hypertrophic cardiomyopathy	30.4	MT-CYB, MT-ND1, IL6, HTR2A, GNAS, CAV3
11	ventricular fibrillation	30.3	KCNE1, KCNH2, KCNJ2, KCNQ1, KCNE2, KCNJ8
12	conduction disease	30.1	SCN4B, SCN1B, SCN5A, SCN3B, MAOA, TGFB1
13	systolic heart failure	29.6	IL6, TNF, CYP2D6, EDN1
14	hyperhomocysteinemia	29.2	IL1B, IL1RN, IL6, APOE, MAOB, EDN1
15	congenital heart defect	27.3	KCNH2, SCN5A, S100A1, MME, IL6, IL6R
16	sleep apnea	26.9	RET, ASCL1, IL10, IL1B, IL4, IL6
17	apnea	26.6	RET, CHAT, ASCL1, IL10, IL1B, IL4
18	acute myocardial infarction	26.1	VEGFA, KCNJ8, SCN5A, MME, GSTM1, GSTT1
19	myocardial infarction	25.8	VEGFA, KCNE1, KCNQ1, KCND3, KCNE2, KCNJ8
20	atrial fibrillation	25.8	KCNE1, KCNH2, KCNJ2, KCNQ1, KCND3, KCNE2
21	hepatitis c	25.4	MX1, IL10, IL2, IL4, IL6R, IFNG
22	congestive heart failure	25.3	VEGFA, KCNJ2, KCNQ1, KCNE2, SCN5A, MME
23	bronchiolitis	25.3	S100A1, FOS, GSTT1, IL10, IL1B, IL1RN
24	hypoxia	24.5	RET, PCK2, VEGFA, BMP2, KCNH2, KCNJ8
25	laryngitis	23.9	VEGFA, S100A1, GSTM1, GSTT1, IL10, IL1B
26	atherosclerosis	21.2	GCK, VEGFA, BMP2, UCP1, MME, FOS
27	neuronitis	20.1	RET, PCK2, GCK, VEGFA, BMP2, KCNH2
28	hepatitis	19.7	PCK2, GCK, VEGFA, CKAP5, CHAT, MX1
29	colon cancer	19.6	VEGFA, BMP2, KCNH2, SCN5A, CHAT, MME
30	hypertension	18.6	RET, GCK, VEGFA, BMP2, KCNH2, KCND3
31	haddad syndrome	14.0	ASCL1, PHOX2B, TH
32	fatty acid oxidation disorders	14.0	ACADS, ACADL, ACADM, ACADVL, SLC25A20, CPT1A
33	right bundle branch block	13.9	SCN1B, SCN5A, SCN3B, GPD1L
34	short-chain acyl-coa dehydrogenase deficiency	13.9	PCK2, ACADS, ACADM
35	familial atrial fibrillation	13.9	KCNQ1, KCNE2, SCN5A
36	autistic disorder	13.9	HTR1A, HTR2A, HTR3A, TH, SLC6A4, ADCYAP1
37	long qt syndrome 1	13.9	KCNE1, KCNH2, KCNQ1, KCNE2, SCN5A
38	neurotic disorder	13.9	MAOA, HTR1A, HTR2A, HTR3A, SLC6A4
39	vlcad deficiency	13.9	PCK2, ACADS, ACADL, ACADM, ACADVL, CPT1A
40	jervell-lange nielsen syndrome	13.9	KCNE1, KCNH2, KCNQ1, KCNE2, SCN4B, SCN5A
41	phenylketonuria	13.9	TPH1, ACADM, TH, HADHA
42	social phobia	13.9	MAOA, HTR1A, HTR3A, SLC6A4
43	short qt syndrome	13.9	KCNH2, KCNJ2, KCNQ1
44	insomnia	13.8	HTR1A, HTR2A, HTR3A, SLC6A4
45	seasonal affective disorder	13.8	HTR1A, HTR2A, TPH1, SLC6A4
46	generalized anxiety disorder	13.8	MAOA, HTR1A, HTR2A, HTR3A, TPH1, SLC6A4
47	hyperammonemia with hypoornithinemia	13.8	GCK, CHAT, ACADS, SLC25A20
48	alcoholic psychosis	13.8	HTR2A, SLC6A3, SLC6A4
49	3-hydroxyacyl-coa dehydrogenase deficiency	13.8	GCK, ACADVL, HADHA
50	fainting	13.8	KCNH2, SCN1B, SCN5A, SCN3B, GPD1L, GNAS

Clinical features from OMIM: 272120

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to sudden infant death syndrome:

²²

MGI Mouse Phenotypes related to sudden infant death syndrome:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.3	KCNE1, EN1, C4B, SLC37A4
2	respiratory system phenotype	MP:0005388	10.0	TH, TLX3, PHOX2B, PHOX2A, TPH2, TPH1
3	renal/urinary system phenotype	MP:0005367	9.4	ACADL, G6PC, TAC1, SLC9A3, SLC22A5, SLC37A4
4	endocrine/exocrine gland phenotype	MP:0005379	9.3	SLC9A3, GNAS, HTR2A, IFNG, EN1, IL2
5	skeleton phenotype	MP:0005390	9.2	ECE1, SLC37A4, CASP3, GNAS, IDS, EN1
6	liver/biliary system phenotype	MP:0005370	9.2	HADHA, ADCYAP1, SLC22A5, TH, ACADVL, ACADM
7	craniofacial phenotype	MP:0005382	9.1	ECE1, EDN1, GNAS, IDS, ASCL1, CKAP5
8	no phenotypic analysis	MP:0003012	9.1	CYP1A1, SST, NTS, PHOX2A, RYR2, TPH2
9	integument phenotype	MP:0010771	9.0	TPH1, TPH2, ACADS, TLX3, TH, SLC6A3
10	adipose tissue phenotype	MP:0005375	8.0	NTS, NOS2, ACADVL, TGFB1, ADCYAP1, TNF
11	nervous system phenotype	MP:0003631	7.9	ADCYAP1, IDS, MAOB, MAOA, EN1, FEV
12	immune system phenotype	MP:0005387	7.3	GNAS, CAV3, TNF, GFAP, TLX3, SLC37A4
13	growth/size phenotype	MP:0005378	7.1	GFAP, G6PC, ACADVL, PHOX2B, PHOX2A, NTS
14	digestive/alimentary phenotype	MP:0005381	7.0	CASP3, SST, NOS2, EDN1, C4B, GFAP
15	normal phenotype	MP:0002873	6.9	PHOX2B, SST, CYP1A1, GNAS, IFNG, G6PC
16	vision/eye phenotype	MP:0005391	6.5	CASP3, TNF, NOS2, PHOX2B, GFAP, TH
17	reproductive system phenotype	MP:0005389	6.4	IFNG, CASP3, TNF, NOS2, ACADL, TGFB1
18	mortality/aging	MP:0010768	6.1	KCNJ8, KCNJ2, KCNH2, BMP2, VEGFA, GCK
19	muscle phenotype	MP:0005369	5.6	ACADVL, ACADM, ACADS, EDN1, NOS2, SNTA1
20	cellular phenotype	MP:0005384	5.0	TNF, CAV3, CASP3, GNAS, IDS, IFNG
21	homeostasis/metabolism phenotype	MP:0005376	4.3	TH, TLX3, GFAP, G6PC, ACADVL, ACADM
22	behavior/neurological phenotype	MP:0005386	4.2	SLC6A4, SLC6A3, TAC1, TGFB1, TH, TLX3
23	cardiovascular system phenotype	MP:0005385	3.3	SCN5A, KCNJ8, KCND3, KCNQ1, KCNJ2, KCNH2

Articles related to sudden infant death syndrome:

(show top 50)    (show all 106)

id	Title	Authors	Year	Affiliating Genes
1	Loss-of-function mutations in the KCNJ8-encoded Kir6.1 KATP channel and sudden infant death syndrome. (21836131)	Tester D.J.... Ackerman M.J.	2011	KCNJ8
2	Lack of association of the serotonin transporter poly morphism with the sudden infant death syndrome in the San Diego Dataset. (20661167)	Paterson D.S.... Markianos K.	2010	SLC6A4
3	A common FMO3 polymorphism may amplify the effect of nicotine exposure in sudden infant death syndrome (SIDS). (20198379)	Poetsch M.... Bajanowski T.	2010	FMO3
4	Impact of sodium/proton exchanger 3 gene variants on sudden infant death syndrome. (19772970)	Poetsch M.... Bajanowski T.	2010	SLC9A3
5	HTR2A variation and sudden infant death syndrome: a case-control analysis. (18771483)	Rand C.M.... Weese-Mayer D.E.	2009	HTR2A
6	The role of 5-HT3 and other excitatory receptors in central cardiorespiratory responses to hypoxia: implications for sudden infant death syndrome. (19247214)	Dergacheva O.... Mendelowitz D.	2009	HTR3A
7	Sudden Infant Death Syndrome and Sudden Intrauterine Unexplained Death: Correlation Between Hypoplasia of RaphAc Nuclei and Serotonin Transporter Gene Promoter Polymorphism. (19342987)	Lavezzi A.M.... Matturri L.	2009	SLC6A4
8	Serotoninergic receptor 1A in the sudden infant death syndrome brainstem medulla and associations with clinical risk factors. (19052756)	Machaalani R.... Waters K.A.	2009	HTR1A
9	Apolipoprotein E e4 and its prevalence in early childhood death due to sudden infant death syndrome or to recognised causes. (18280677)	Becher J.C.... McIntosh N.	2008	APOE, IDS
10	The IL6 -174G/C polymorphism and sudden infant death syndrome. (17509454)	Opdal S.H.... Rognum T.O.	2007	IL6
11	Genetic variation in hepatic glucose-6-phosphatase system genes in cases of sudden infant death syndrome. (17354259)	Forsyth L.... Burchell A.	2007	G6PC, SLC37A4
12	A mitochondrial DNA polymorphism associated with cardiac arrhythmia investigated in sudden infant death syndrome. (17429906)	Arnestad M.... Rognum T.O.	2007	KCNH2, MT-ND1
13	Active caspase-3 in the sudden infant death syndrome (SIDS) brainstem. (17364171)	Machaalani R.... Waters K.A.	2007	CASP3
14	Mitochondrial tRNA genes and flanking regions in sudden infant death syndrome. (17429907)	Opdal S.H.... Rognum T.O.	2007	MT-ND3
15	Prevalence of long-QT syndrome gene variants in sudden infant death syndrome. (17210839)	Arnestad M.... Schwartz P.J.	2007	KCNQ1, KCNH2, KCNE1
16	Genetic investigation of the TSPYL1 gene in sudden infant death syndrome. (16418600)	Hering R.... Riess O.	2006	TSPYL1
17	Nicotine metabolizing genes GSTT1 and CYP1A1 in sudden infant death syndrome. (16763966)	Rand C.M.... Berry-Kravis E.M.	2006	CYP1A1, GSTT1
18	Sudden infant death syndrome: Case-control frequency differences in paired like homeobox (PHOX) 2B gene. (16830328)	Rand C.M.... Berry-Kravis E.M.	2006	PHOX2B
19	Infection, health problems, and health care utilisation, and the risk of sudden infant death syndrome. (15851437)	Vennemann M.M.... Mitchell E.A.	2005	IDS
20	Epidemiology of 25 years of crib death (sudden infant death syndrome) in the Netherlands; incidence of crib death and prevalence of risk factors in 1980-2004 (15960133)	de Jonge G.A.... Hoogenboezem J.	2005	IDS
21	Ethnicity, infection and sudden infant death syndrome. (15325398)	Blackwell C.C.... Busuttil A.	2004	IDS
22	Update on sudden infant death syndrome. (15021209)	Daley K.C.	2004	IDS
23	Interleukin-10 and sudden infant death syndrome. (15325406)	Moscovis S.M.... Blackwell C.C.	2004	IL10
24	Sudden infant death syndrome: case-control frequency differences at genes pertinent to early autonomic nervous system embryologic development. (15240857)	Weese-Mayer D.E.... Marazita M.L.	2004	RET, BMP2, ECE1
25	Interleukin 10 genotype as a risk factor for sudden infant death syndrome: determination of IL-10 genotype from wax-embedded postmortem samples. (15325405)	Korachi M.... Drucker D.B.	2004	IDS, IL10
26	Vascular endothelial growth factor in the cerebrospinal fluid of infants who died of sudden infant death syndrome: evidence for antecedent hypoxia. (12563064)	Jones K.L.... Gozal D.	2003	VEGFA
27	A serotonin malfunction hypothesis by finding clear mutual relationships between several risk factors and symptoms associated with sudden infant death syndrome. (12018976)	Okado N.... Narita N.	2002	SLC6A4
28	Sudden infant death syndrome: is it a transepithelial transport disorder? (12323127)	Reid G.M.	2002	NOS2
29	Intrauterine hypoxia and sudden infant death syndrome (12630342)	Habek D.... SalihagiA8 A.	2002	IL6
30	Developmental neurotransmitter pathology in the brain stem of sudden infant death syndrome: a review and sleep position. (12350301)	Ozawa Y.... Takashima S.	2002	HTR1A
31	Are risk factors for sudden infant death syndrome dif ferent at night? (12243991)	Williams S.M.... Taylor B.J.	2002	IDS
32	Elevated serum concentrations of beta-tryptase, but not alpha-tryptase, in Sudden Infant Death Syndrome (SIDS). An investigation of anaphylactic mechanisms. (11696045)	Buckley M.G.... Walls A.F.	2001	TPSAB1
33	Sudden infant death syndrome Part 2: the response of the reticuloendothelial system to hypoxemia and infection. (11421619)	Reid G.M.	2001	MME
34	Postmortem molecular analysis of SCN5A defects in sudden infant death syndrome. (11710892)	Ackerman M.J.... Towbin J.A.	2001	SCN5A
35	Ontogenesis of CYP2C-dependent arachidonic acid metabolism in the human liver: relationship with sudden infant death syndrome. (10813596)	Treluyer J.M.... Cresteil T.	2000	CYP2C9
36	IL-6 cerebrospinal fluid levels are related to laryngeal IgA and epithelial HLA-DR response in sudden infant death syndrome. (10367769)	Vege A.... Anestad G.	1999	IL6
37	Transcriptional activation of CYP2C, MxA and Fas in sudden infant death syndrome. (9864383)	Beurton F.... Cresteil T.	1999	CYP2C19, MX1
38	Catecholamine neurons alteration in the brainstem of sudden infant death syndrome victims. (9445505)	Obonai T.... Takashima S.	1998	TH
39	Cytochrome P450 2D6 and glutathione S-transferase genotype in sudden infant death syndrome. (9069041)	Chen C.L.... Relling M.V.	1997	CYP2D6, GSTT1, GSTM1
40	Frequency of 985A-to-G mutation in medium-chain acyl-CoA dehydrogenase gene among patients with sudden infant death syndrome, Reye syndrome, severe motor and intellectual disabilities and healthy newborns in Japan. (8840534)	Nagao M.	1996	ACADM
41	Human heat shock protein gene polymorphisms and sudden infant death syndrome. (8957963)	Rahim R.A.... Burdon R.H.	1996	HSPA14
42	Reduction in mortality from sudden infant death syndrome in New Zealand: 1986-92. (8185361)	Mitchell E.A.... Everard C.	1994	IDS
43	Medium-chain acyl-CoA dehydrogenase deficiency does not correlate with apparent life-threatening events and the sudden infant death syndrome: results from phenylpropionate loading tests and DNA analysis. (8033926)	Penzien J.M.... Wermuth B.	1994	ACADM
44	Well health care and the sudden infant death syndrome. (8198848)	Ford R.P.... Taylor B.J.	1994	IDS
45	Proliferation of dendritic cells in the bronchioles of sudden infant death syndrome victims. (8346185)	Haque A.K.... Mancuso M.G.	1993	S100A1
46	Synaptic neurochemistry of human striatum during development: changes in sudden infant death syndrome. (8098354)	Kalaria R.N.... Sparks D.L.	1993	MAOB, CHAT, SST
47	Scottish frequency of the common G985 mutation in the medium-chain acyl-CoA dehydrogenase (MCAD) gene and the role of MCAD deficiency in sudden infant death syndrome (SIDS). (8127075)	Dundar M.... Connor J.M.	1993	ACADM
48	Frequency of medium-chain acyl-CoA dehydrogenase deficiency G-985 mutation in sudden infant death syndrome. (1570195)	Miller M.E.... Insel R.	1992	ACADM
49	Inherited metabolic diseases in the sudden infant death syndrome. (1755645)	Holton J.B.... Berry P.J.	1991	ACADM
50	Sudden infant death syndrome: altered aminergic-cholinergic synaptic markers in hypothalamus. (1719064)	Sparks D.L.... Hunsaker J.C.	1991	MAOA, MAOB, CHAT

Genes related to sudden infant death syndrome according to GeneCards:

(show top 50)    (show all 102)

id	Symbol	Description	Score	GeneCards Section Context
1	SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	11.1	Summaries, Publications
2	KCNJ8	potassium inwardly-rectifying channel, subfamily J, member 8	11.1	Summaries, Publications
3	GPD1L	glycerol-3-phosphate dehydrogenase 1-like	11.1	Summaries, Publications
4	SCN5A	sodium channel, voltage-gated, type V, alpha subunit	11.1	Publications
5	SNTA1	syntrophin, alpha 1	11.0	Summaries
6	IDS	iduronate 2-sulfatase	11.0	Publications
7	EN1	engrailed homeobox 1	11.0	Publications
8	TSPYL1	TSPY-like 1	11.0	Publications
9	PHOX2B	paired-like homeobox 2b	11.0	Publications
10	ACADM	acyl-CoA dehydrogenase, C-4 to C-12 straight chain	11.0	Publications
11	ECHS1	enoyl CoA hydratase, short chain, 1, mitochondrial	11.0
12	CAV3	caveolin 3	11.0	Publications
13	SLC25A20	solute carrier family 25 (carnitine/acylcarnitine translocase), member 20	11.0
14	ACADS	acyl-CoA dehydrogenase, C-2 to C-3 short chain	11.0
15	HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	11.0
16	NTS	neurotensin	11.0	Publications
17	G6PC	glucose-6-phosphatase, catalytic subunit	11.0	Publications
18	GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	11.0	Publications
19	ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	11.0	Publications
20	SLC22A5	solute carrier family 22 (organic cation/carnitine transporter), member 5	11.0
21	C4B	complement component 4B (Chido blood group)	11.0
22	C4A	complement component 4A (Rodgers blood group)	11.0
23	CHAT	choline O-acetyltransferase	11.0	Publications
24	KCNH2	potassium voltage-gated channel, subfamily H (eag-related), member 2	11.0	Publications
25	UCP1	uncoupling protein 1 (mitochondrial, proton carrier)	11.0
26	ACADVL	acyl-CoA dehydrogenase, very long chain	11.0
27	HTR3A	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	11.0	Publications
28	TH	tyrosine hydroxylase	11.0	Publications
29	HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	11.0	Publications
30	FEV	FEV (ETS oncogene family)	11.0	Publications
31	PHOX2A	paired-like homeobox 2a	11.0	Publications
32	SCN4B	sodium channel, voltage-gated, type IV, beta subunit	11.0	Publications
33	TLX3	T-cell leukemia homeobox 3	11.0	Publications
34	SCN2B	sodium channel, voltage-gated, type II, beta subunit	11.0	Publications
35	TPSAB1	tryptase alpha/beta 1	11.0	Publications
36	SLC37A4	solute carrier family 37 (glucose-6-phosphate transporter), member 4	11.0	Publications
37	ACADL	acyl-CoA dehydrogenase, long chain	11.0
38	ASCL1	achaete-scute complex homolog 1 (Drosophila)	11.0	Publications
39	ARFGAP2	ADP-ribosylation factor GTPase activating protein 2	11.0
40	EN2	engrailed homeobox 2	11.0
41	ZBED1	zinc finger, BED-type containing 1	11.0
42	KCNE2	potassium voltage-gated channel, Isk-related family, member 2	11.0	Publications
43	SCN1B	sodium channel, voltage-gated, type I, beta subunit	11.0	Publications
44	PNMT	phenylethanolamine N-methyltransferase	11.0	Publications
45	SCN3B	sodium channel, voltage-gated, type III, beta subunit	11.0	Publications
46	KCNJ2	potassium inwardly-rectifying channel, subfamily J, member 2	11.0	Publications
47	MT-CYB	mitochondrially encoded cytochrome b	11.0
48	PYGM	phosphorylase, glycogen, muscle	11.0	Publications
49	PCK2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	11.0	Publications
50	ZFP106	zinc finger protein 106 homolog (mouse)	11.0

Pathways related to sudden infant death syndrome according to GeneDecks:

(show top 50)    (show all 74)

id	Pathway	Score	Top Affiliating Genes
1	Fatty acid metabolism20	10.7	ACADVL, CPT1A, ACADL, ACADS, ACADM, ECHS1
2	Neuropathic Pain-Signaling in Dorsal Horn Neurons36	10.4	TAC1, GRIN1, FOS, SCN1B, SCN5A, SCN3B
3	Fluoxetine Pathway, Pharmacokinetics34	10.4	CYP2C9, CYP2D6, CYP2C19, SLC6A4
4	Potassium transporters- outward current10	10.4	SLC6A4, KCND3, KCNQ1, KCNJ2, KCNH2, KCNE1
5	Tryptophan metabolism20	10.4	CYP1A1, ECHS1, HADHA, TPH1, MAOA, MAOB
6	Tyrosine metabolism p.1 (dopamine)41	10.4	MAOA, PNMT, TH, MAOB
7	Tyrosine metabolism p.1 (dopamine)10	10.4	MAOB, PNMT, MAOA, TH
8	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	10.3	MAOA, HTR2A, GNAS, TPH1, TPH2, SLC6A4
9	Gefitinib Pathway, Pharmacokinetics34	10.3	CYP2C19, CYP2D6, CYP2C9, CYP1A1
10	Graft-versus-host disease20	10.2	IL2
11	Tamoxifen Pathway, Pharmacokinetics34	10.1	CYP2C9, CYP2D6, CYP2C19, FMO3
12	Estradiol metabolism41	9.9	CYP2D6, CYP2C9, CYP2C19, CYP1A1
13	Citalopram Pathway, Pharmacokinetics34	9.9	SLC6A4, CYP2C19, CYP2D6
14	Antiarrhythmic Pathway, Pharmacodynamics34	9.8	SCN2B, SCN1B, SCN4B, KCNJ8, KCNE2, KCND3
15	Drug metabolism - cytochrome P45020	9.8	CYP2C9, GSTT1, FMO3, GSTM1, MAOA, MAOB
16	Estradiol metabolism10	9.8	CYP2C9, CYP2D6, CYP1A1, CYP2C19
17	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.7	TGFB1, IL6, IL4, IL1B
18	Selected targets of GCR-alpha10	9.7	CYP2C9, CHAT, IL4, IL1B, IL6, CYP2C19
19	Amoebiasis20	9.6	TGFB1, IL1B, IL6, GNAS, NOS2
20	PGC1Alpha Pathway36	9.4	IL1B, IL2, IL4, BMP2
21	IL-6 Pathway36	9.3	IL4, BMP2, IL10, IL6R
22	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.3	IL1B, TGFB1, IFNG, IL6R, IL6, IL4
23	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.1	IL6, IL1B, APOE, FOS, IFNG, TNF
24	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.0	IFNG, IL6, TNF, APOE, FOS, IL1B
25	Immune response MIF in innate immunity response10	8.9	TNF, NOS2, IFNG, IL6, IL1B
26	Immune response_MIF in innate immunity response41	8.9	IL1B, NOS2, IFNG, IL6, TNF
27	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.9	TNF, TGFB1, IL10, IL2
28	Rheumatoid arthritis20	8.8	IL1B, FOS, IL6, IFNG, TNF, TGFB1
29	Immune response MIF-mediated glucocorticoid regulation10	8.8	IL6, IL2, IFNG, FOS, NOS2, TNF
30	African trypanosomiasis20	8.7	IL1B, IL6, IFNG, TNF, IL10
31	Immune response_MIF-mediated glucocorticoid regulation41	8.7	TNF, NOS2, IFNG, IL6, IL2, FOS
32	Metabolic pathways20	8.7	ACADM, ACADVL, G6PC, TH, ACADL, ACADS
33	Malaria20	8.6	TGFB1, IFNG, IL6, TNF, IL10, IL1B
34	Immune response IL-1 signaling pathway10	8.5	TNF, IL6, EDN1, NOS2, FOS, IL1B
35	Immune response_IL-1 signaling pathway41	8.5	FOS, TNF, IL1B, NOS2, EDN1, IL6
36	Allograft rejection20	8.5	TNF, IL10, IFNG, IL4, IL2
37	Pertussis20	8.5	TNF, FOS, IL10, IL1B, IL6, CASP3
38	THC Differentiation Pathway36	8.4	IL10, TNF, IFNG, IL2, IL4
39	Th1 Differentiation37	8.3	TNF, IL10, IFNG, FOS, IL2
40	Glucocorticoid Receptor Signaling36	8.2	IL6R, IL1B, IL10, IL6, IL4, IL2
41	Leishmaniasis20	8.1	FOS, IL10, TGFB1, NOS2, TNF, IFNG
42	MIF Mediated Glucocorticoid Regulation36	8.1	TNF, IL10, BMP2, IL6, IL4, IL2
43	TGF-Beta Pathway36	8.1	FOS, IL6R, BMP2, IL2, TGFB1, IL6
44	PEDF Induced Signaling36	8.1	IL1B, IL4, IL6, IL2, FOS, TNF
45	MIF Regulation of Innate Immune Cells36	8.0	FOS, BMP2, IL10, IL1B, IL2, IL4
46	Cytokine Network36	8.0	IL6, IL2, IFNG, TNF, IL1B, IL10
47	Tuberculosis20	7.8	TGFB1, TNF, IL10, IL6, IL1B, IFNG
48	Endothelin-1 Signaling Pathway36	7.5	IL1B, EDN1, ECE1, CASP3, IL6, IL4
49	Chagas disease (American trypanosomiasis)20	7.4	TGFB1, NOS2, TNF, GNAS, IL6, IL2
50	Cytokine-cytokine receptor interaction20	7.2	VEGFA, TNF, IL2, BMP2, IL10, IL6

Compounds related to sudden infant death syndrome according to GeneDecks:

(show top 50)    (show all 492)

id	Compound	Score	Top Affiliating Genes
1	mdma32	10.2	SLC6A4, SLC6A3, TH, NTS, CYP2D6, TPH1
2	nicotine32 34 9 9	13.0	CYP2C19, GRP, FMO3, BMP2, CYP2D6, CYP2C9
3	maoa32	10.0	HTR2A, HTR1A, MAOB, MAOA, TPH1, TPH2
4	methamphetamine32 9 9	12.0	CHAT, SLC6A4, SLC22A5, SLC6A3, TH, GFAP
5	glucose32	10.0	PYGM, HSPA14, MME, MT-ND1, MT-CYB, NTS
6	haloperidol32 34 9 9	12.9	TH, NTS, CYP2C9, CYP1A1, HTR3A, HTR2A
7	corticosterone32 18	10.9	TH, GFAP, PNMT, NTS, IL1RN, IL1B
8	fluvoxamine32 34 9 9	12.9	HTR1A, MAOA, HTR2A, HTR3A, SLC6A4, SLC6A3
9	amitriptyline32 34 42 9 9	13.8	SLC6A4, SLC6A3, CYP2C9, CYP2D6, CYP2C19, HTR3A
10	venlafaxine32 34 9 18 9	13.8	HTR1A, HTR2A, TPH2, CYP2C19, CYP2D6, CYP2C9
11	citalopram32 34 9 18 9	13.7	SLC6A4, SLC6A3, CYP2C9, CYP2D6, CYP2C19, CYP1A1
12	paroxetine32 34 9 9	12.7	TPH1, CYP2D6, CYP2C19, HTR3A, HTR2A, HTR1A
13	amphetamine32 9 9	11.7	SLC6A4, SLC22A5, SLC6A3, TAC1, TH, NTS
14	olanzapine32 34 9 18 9	13.6	FMO3, FOS, CHAT, KCNH2, APOE, HTR1A
15	clozapine32 34 9 9	12.5	HTR3A, HTR2A, HTR1A, IL10, FMO3, FOS
16	imipramine32 34 9 18 9	13.4	MAOB, MAOA, FMO3, CHAT, KCND3, IFNG
17	choline32 9 18 9	12.3	SLC6A4, NTS, MAOA, RET, CHAT, GRP
18	epinephrine32 9 18 9	12.3	ADCYAP1, GRP, KCNQ1, IL1RN, MAOB, TH
19	isoproterenol32 9 9	11.2	KCNQ1, KCNJ2, KCNH2, GNAS, CAV3, ADCYAP1
20	sodium32 18	10.1	CYP2C9, KCNE1, KCNH2, CAV3, MBL2, MME
21	desipramine32 34 9 9	12.1	HTR2A, SLC6A4, SLC22A5, MAOA, HTR1A, GNAS
22	pge232	9.1	ADCYAP1, EDN1, NTS, SST, GNAS, IL1RN
23	potassium32 9 18 9	12.0	NTS, CYP2C9, HSPA14, MME, MT-CYB, CHAT
24	glutamate32	8.8	HADHA, ADCYAP1, RYR2, TAC1, TH, GFAP
25	fluoxetine32 34 9 9	11.8	SLC6A3, TAC1, CYP2C9, CYP2D6, CYP2C19, TPH2
26	cysteine32	8.7	TPH1, GFAP, CASP3, IDS, IFNG, MAOB
27	testosterone32 9 18 9	11.7	ADCYAP1, SLC6A4, TAC1, TH, GFAP, NTS
28	dopamine32 9 18 9	11.7	TAC1, ADCYAP1, SLC6A4, SLC22A5, SLC9A3, SLC6A3
29	alanine32	8.6	MX1, CHAT, SCN5A, KCNH2, BMP2, GCK
30	5-hydroxytryptamine32	8.5	TPH2, TPH1, HTR3A, HTR2A, HTR1A, MAOB
31	vegf32	8.3	GFAP, MBL2, CYP1A1, SST, ADCYAP1, ECE1
32	nifedipine32 9 9	10.3	TGFB1, EDN1, NTS, SST, CYP2C9, CYP2D6
33	norepinephrine32 9 18 9	11.3	PNMT, GRIN1, UCP1, CHAT, GRP, IL1RN
34	creatinine32	8.2	SLC9A3, KCNH2, BMP2, GCK, MT-CYB, GSTM1
35	acetylcholine32 9 18 9	11.1	ADCYAP1, SLC22A5, SLC6A3, TAC1, TH, GFAP
36	histamine32 18	9.0	IL4, IL2, IL1RN, GRP, MME, IL6R
37	oxygen32 18	8.7	ADCYAP1, CPT1A, TH, GFAP, ACADM, C4A
38	lactate32	7.5	HADHA, CPT1A, SLC37A4, SLC9A3, TGFB1, TH
39	arginine32	7.4	SST, BMP2, GCK, RET, KCNE1, KCNH2
40	neopterin32	6.9	IL2, MX1, IL10, IL1B, IL1RN, IL4
41	retinoic acid32 42 18	8.6	SST, CYP2C9, CYP2D6, CYP2C19, CYP1A1, TNF
42	tyrosine32	6.5	PNMT, NTS, CYP2C9, CYP2D6, CYP2C19, PYGM
43	lipid32	6.5	CYP2D6, UCP1, MX1, CHAT, KCND3, KCNH2
44	indomethacin32 9 9	7.8	CYP1A1, TNF, IFNG, APOE, IL6, IL4
45	serine32	5.7	KCNH2, KCNE1, BMP2, GCK, RET, HADHA
46	thymidine32 18	6.6	ADCYAP1, TGFB1, GFAP, EDN1, NTS, CYP2C9
47	actinomycin d32	5.5	ADCYAP1, IL4, IL2, IL1B, GRP, FOS
48	nitric oxide32 9 18 9	7.8	CHAT, IL1RN, IL1B, IL10, GRIN1, MME
49	dexamethasone32 42 34 9 9	8.7	ADCYAP1, SLC9A3, TAC1, TGFB1, TH, GFAP
50	cycloheximide32	4.2	ADCYAP1, SLC9A3, TGFB1, GFAP, IL1B, IL10

Cellular components related to sudden infant death syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	voltage-gated sodium channel complex	GO:001518	10.4	SCN3B, SCN2B, SCN5A, SCN1B, SCN4B
2	sarcolemma	GO:042383	10.3	SNTA1, CAV3, SCN5A, KCNJ8, KCND3, KCNQ1
3	voltage-gated potassium channel complex	GO:008076	10.1	KCNJ8, KCNE2, KCND3, KCNQ1, KCNH2, KCNE1
4	axon	GO:030424	9.4	SLC6A3, TAC1, TGFB1, ACADM, HTR3A, MME
5	neuronal cell body	GO:043025	9.4	SLC6A3, TAC1, TGFB1, SST, HTR3A, APOE
6	plasma membrane	GO:005886	7.2	C4A, TNF, CAV3, CASP3, GNAS, HTR3A
7	extracellular region	GO:005576	6.2	TPSAB1, SST, NTS, EDN1, C4A, C4B
8	extracellular space	GO:005615	5.2	VEGFA, IFNG, TPSAB1, TNF, SST, EDN1

Biological processes related to sudden infant death syndrome according to GeneDecks:

(show all 47)

id	Name	GO ID	Score	Top Affiliating Genes
1	fatty acid beta-oxidation using acyl-CoA dehydrogenase	GO:033539	10.8	ACADVL, ACADM, ACADL, ACADS
2	regulation of ventricular cardiomyocyte membrane repolarization	GO:060307	10.8	CAV3, SCN5A, SCN1B, SCN4B
3	membrane depolarization involved in regulation of cardiac muscle cell action potential	GO:086012	10.7	SCN3B, SCN5A, SCN1B, SCN4B
4	regulation of cardiac muscle cell action potential involved in contraction	GO:086002	10.7	SCN3B, SCN2B, SCN5A, SCN1B, SCN4B
5	regulation of atrial cardiomyocyte membrane depolarization	GO:060371	10.7	SCN3B, SCN2B, SCN5A, SCN1B
6	regulation of heart rate by cardiac conduction	GO:086091	10.7	SCN3B, SCN2B, SCN5A, SCN1B, SCN4B, KCNH2
7	regulation of sodium ion transmembrane transporter activity	GO:2000649	10.7	CAV3, SCN3B, SCN2B, SCN1B, SCN4B
8	sodium ion transmembrane transport	GO:035725	10.7	SCN3B, SCN2B, SCN5A, SCN1B, SCN4B
9	regulation of ventricular cardiomyocyte membrane depolarization	GO:060373	10.7	CAV3, SCN3B, SCN5A
10	fatty acid beta-oxidation	GO:006635	10.7	HADHA, ECHS1, CPT1A, ACADVL, ACADM, ACADL
11	cellular lipid metabolic process	GO:044255	10.6	HADHA, ECHS1, CPT1A, SLC25A20, ACADVL, ACADM
12	neuron fate specification	GO:048665	10.5	ASCL1, FEV, TLX3
13	regulation of heart contraction	GO:008016	10.5	TH, CAV3, S100A1, KCNE2, KCNQ1, KCNH2
14	chronic inflammatory response to antigenic stimulus	GO:002439	10.4	IL1RN, IL1B
15	memory	GO:007613	10.4	SLC6A4, TH, HTR2A, IL1RN, IL1B, CHAT
16	monoterpenoid metabolic process	GO:016098	10.3	CYP2C9, CYP2D6, CYP2C19
17	regulation of ventricular cardiac muscle cell action potential	GO:086005	10.3	RYR2, SCN3B, SCN5A
18	cardiac muscle contraction	GO:060048	10.3	RYR2, SCN3B, SCN2B, SCN5A, SCN1B, SCN4B
19	drug metabolic process	GO:017144	10.2	CYP2C9, CYP2D6, CYP2C19, CYP1A1, FMO3
20	triglyceride metabolic process	GO:006641	10.2	CPT1A, G6PC, CAV3, APOE
21	response to ethanol	GO:045471	10.1	SLC6A3, TH, MAOB, IL4, GRIN1, CHAT
22	oxidation-reduction process	GO:055114	10.1	ACADM, ACADL, CYP2C9, CYP2D6, CYP2C19, CYP1A1
23	synaptic transmission	GO:007268	9.9	SLC6A3, TAC1, SST, HTR3A, HTR2A, MAOA
24	membrane depolarization	GO:051899	9.8	EDN1, SCN3B, SCN5A, SCN1B, KCNE1
25	xenobiotic metabolic process	GO:006805	9.8	CYP2C9, CYP2D6, CYP2C19, CYP1A1, MAOB, MAOA
26	sensory perception of pain	GO:019233	9.7	TAC1, EDN1, HTR2A, GRIN1, MME, SCN3B
27	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.6	TNF, IFNG, IL1B
28	positive regulation of isotype switching to IgG isotypes	GO:048304	9.5	IFNG, IL4, IL2
29	positive regulation of odontogenesis	GO:042482	9.5	TGFB1, EDN1, BMP2
30	positive regulation of membrane protein ectodomain proteolysis	GO:051044	9.4	TNF, IFNG, APOE, IL1B
31	defense response to Gram-positive bacterium	GO:050830	9.4	IL6, IL6R, MBL2, TNF
32	positive regulation of chemokine biosynthetic process	GO:045080	9.4	TNF, IFNG, IL4, IL1B
33	positive regulation of MHC class II biosynthetic process	GO:045348	9.3	IFNG, IL4, IL10
34	cellular response to organic cyclic compound	GO:071407	9.1	TGFB1, TNF, IL1B, BMP2
35	negative regulation of growth of symbiont in host	GO:044130	9.1	IL10, MBL2, IFNG, TNF
36	positive regulation of interleukin-6 production	GO:032755	9.0	TNF, IL6R, IL6, IL1B
37	positive regulation of MAP kinase activity	GO:043406	9.0	TGFB1, EDN1, TNF, HTR2A, VEGFA
38	regulation of insulin secretion	GO:050796	8.9	CPT1A, NOS2, TNF, GNAS, IFNG, IL1B
39	elevation of cytosolic calcium ion concentration	GO:007204	8.9	TAC1, EDN1, CAV3, IL2, IL1B, GCK
40	response to glucocorticoid stimulus	GO:051384	8.9	SLC9A3, ACADS, TNF, TPH2, IL6, IL1RN
41	small molecule metabolic process	GO:044281	8.7	PCK2, CYP2D6, CYP2C9, PNMT, ACADS, ACADL
42	positive regulation of nitric oxide biosynthetic process	GO:045429	8.6	EDN1, TNF, IFNG, IL1B
43	inflammatory response	GO:006954	8.5	TAC1, TGFB1, C4B, C4A, TNF, IL6
44	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.8	EN2, IFNG, TNF, PHOX2A, PHOX2B, TGFB1
45	cell-cell signaling	GO:007267	7.8	ADCYAP1, TAC1, EDN1, SST, IL2, IL1B
46	response to hypoxia	GO:001666	7.6	ECE1, RYR2, SLC6A4, TGFB1, TH, EDN1
47	response to drug	GO:042493	7.3	SST, EDN1, TGFB1, SLC6A3, SLC6A4, CPT1A

Molecular functions related to sudden infant death syndrome according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential	GO:086006	10.5	SCN4B, SCN1B, SCN5A, SCN2B, SCN3B
2	acyl-CoA dehydrogenase activity	GO:003995	10.5	ACADVL, ACADM, ACADL, ACADS
3	sodium channel regulator activity	GO:017080	10.5	CAV3, SCN3B, SCN2B, SCN1B, SCN4B
4	serotonin binding	GO:051378	10.4	HTR3A, HTR2A, HTR1A, MAOA
5	flavin adenine dinucleotide binding	GO:050660	10.0	ACADVL, ACADM, ACADL, ACADS, NOS2, MAOB
6	voltage-gated potassium channel activity	GO:005249	9.9	HTR3A, KCNE2, KCNQ1, KCNH2, KCNE1
7	drug binding	GO:008144	9.8	SLC6A3, CYP2C9, CYP2D6, PYGM, HTR2A, HTR1A
8	iron ion binding	GO:005506	9.4	TH, NOS2, CYP2C9, CYP2D6, CYP2C19, CYP1A1
9	protein homodimerization activity	GO:042803	8.8	SLC6A4, TGFB1, NOS2, GPD1L, MAOB, APOE
10	growth factor activity	GO:008083	7.7	TGFB1, IL6, IL4, IL2, IL1B, IL10
11	cytokine activity	GO:005125	6.6	EDN1, TNF, IFNG, IL6, IL4, IL2