MCID: SDD001
MIFTS: 60

Sudden Infant Death Syndrome

Categories: Genetic diseases, Rare diseases

Aliases & Classifications for Sudden Infant Death Syndrome

MalaCards integrated aliases for Sudden Infant Death Syndrome:

Name: Sudden Infant Death Syndrome 54 12 50 71 29 52 41 3 3 3 14 69
Sids 12 50 71 3
Sudden Infant Death Syndrome, Susceptibility to 13
Sudden Death of Nonspecific Cause in Infancy 12
Sudden Infant Death Syndrome Nos 12
Sudden Infant Death 42
Crib Death 12
Cot Death 12

Characteristics:

OMIM:

54
Inheritance:
? autosomal recessive form vs. multifactorial


HPO:

32
sudden infant death syndrome:
Mortality/Aging sudden death


Classifications:



External Ids:

OMIM 54 272120
Disease Ontology 12 DOID:9007
ICD9CM 35 798.0
MeSH 42 D013398
NCIt 47 C85173
MedGen 40 C0038644
ICD10 33 R95
SNOMED-CT via HPO 65 26636000
UMLS 69 C0038644

Summaries for Sudden Infant Death Syndrome

MedlinePlus : 41 sudden infant death syndrome (sids) is the sudden, unexplained death of an infant younger than one year old. some people call sids "crib death" because many babies who die of sids are found in their cribs. sids is the leading cause of death in children between one month and one year old. most sids deaths occur when babies are between one month and four months old. premature babies, boys, african americans, and american indian/alaska native infants have a higher risk of sids. although health care professionals don't know what causes sids, they do know ways to reduce the risk. these include placing your baby on his or her back to sleep, even for short naps. "tummy time" is for when babies are awake and someone is watching having your baby sleep in your room for at least the first six months. your baby should sleep close to you, but on a separate surface designed for infants, such as a crib or bassinet. using a firm sleep surface, such as a crib mattress covered with a fitted sheet keeping soft objects and loose bedding away from your baby's sleep area breastfeeding your baby making sure that your baby doesn't get too hot. keep the room at a comfortable temperature for an adult. not smoking during pregnancy or allowing anyone to smoke near your baby nih: national institute of child health and human development

MalaCards based summary : Sudden Infant Death Syndrome, also known as sids, is related to cav3-related sudden infant death syndrome and hyperekplexia, and has symptoms including apneic episodes in infancy An important gene associated with Sudden Infant Death Syndrome is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Serotonergic synapse. The drugs Autonomic Agents and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and lung, and related phenotypes are behavior/neurological and cardiovascular system

NIH Rare Diseases : 50 sudden infant death syndrome (sids) is the unexpected, sudden death of a child under age 1 which cannot be explained after a thorough investigation is conducted. infants who are affected by the condition generally appear healthy with no suspicious signs and symptoms prior to the incident. it is the leading cause of death in infants age 1 to 12 months old. the exact underlying cause of sids is unknown; however, scientists suspect that it is likely a multifactorial condition (associated with the effects of multiple genes in combination with lifestyle and environmental factors). although there is no guaranteed way to prevent sids, the american academy of pediatrics has a published list of recommendations for risk reduction. please click on the link to access this resource. last updated: 12/15/2015

UniProtKB/Swiss-Prot : 71 Sudden infant death syndrome: SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive.

OMIM : 54
Sudden infant death syndrome (SIDS) is a diagnosis of exclusion which should be made only after a thorough autopsy without identification of a specific cause of death (Mage and Donner, 2004). Weese-Mayer et al. (2007) provided a detailed review of genetic factors that have been implicated in SIDS. The authors concluded that SIDS represents more than 1 entity and has a heterogeneous etiology most likely involving several different genetically controlled metabolic pathways. (272120)

Disease Ontology : 12 A syndrome that is characterized by the sudden death of an infant that is not predicted by medical history and remains unexplained after a thorough forensic autopsy and detailed death scene investigation.

Wikipedia : 72 Sudden infant death syndrome (SIDS), also known as cot death or crib death, is the sudden unexplained... more...

Related Diseases for Sudden Infant Death Syndrome

Diseases in the Sudden Infant Death Syndrome family:

Cav3-Related Sudden Infant Death Syndrome

Diseases related to Sudden Infant Death Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
id Related Disease Score Top Affiliating Genes
1 cav3-related sudden infant death syndrome 12.2
2 hyperekplexia 11.3
3 reye syndrome 11.2
4 infantile apnea 11.2
5 infantile histiocytoid cardiomyopathy 11.1
6 lipodystrophy, familial partial, type 5 11.1 CAV3 SCN5A SNTA1
7 developmental dysplasia of the hip 2 11.0 GPD1L SCN5A
8 cardiac conduction disease with or without dilated cardiomyopathy 11.0 KCNH2 KCNQ1 SCN5A
9 hyperaldosteronism, familial, type iii 11.0 KCNH2 KCNQ1 SCN5A
10 intellectual disability-cataracts-kyphosis syndrome 11.0 KCNH2 KCNQ1 SCN5A
11 brugada syndrome 1 11.0 KCNH2 KCNQ1 SCN5A
12 sick sinus syndrome 1 11.0 KCNH2 KCNQ1 SCN5A
13 keppen-lubinsky syndrome 11.0 KCNH2 KCNQ1 SCN5A
14 zttk syndrome 11.0 KCNH2 KCNQ1 SCN5A
15 short qt syndrome 1 11.0 KCNH2 KCNQ1 SCN5A
16 ventricular tachycardia, catecholaminergic polymorphic, 1 11.0 KCNH2 KCNQ1 SCN5A
17 syne1-related emery-dreifuss muscular dystrophy 10.9 KCNH2 KCNQ1 SCN5A
18 cone dystrophy 10.9 GPD1L KCNH2 KCNQ1 SCN5A
19 mental retardation, autosomal dominant 11 10.9 KCNH2 KCNQ1 SCN5A SNTA1
20 vascular erectile tumor 10.9 CAV3 KCNH2 KCNQ1 SCN5A
21 prostate malignant phyllodes tumor 10.9 KCNH2 KCNQ1 SCN5A
22 atrial fibrillation, familial, 3 10.9 CAV3 KCNH2 KCNQ1 SCN5A
23 second-degree atrioventricular block 10.9 KCNH2 KCNQ1 SCN5A
24 autoimmune disease of skin and connective tissue 10.9 KCNH2 KCNQ1 SCN5A
25 conjunctival degeneration 10.9 HTR1A HTR2A SLC6A4
26 pompholyx 10.9 HTR1A HTR2A SLC6A4
27 pauci-immune glomerulonephritis with anca 10.9 HTR2A SLC6A4 TH
28 obsessive-compulsive personality disorder 10.9 HTR1A HTR2A SLC6A4
29 acquired aneurysmal subarachnoid hemorrhage 10.9 HTR1A HTR2A SLC6A4
30 primary angle-closure glaucoma 10.9 HTR1A HTR2A SLC6A4
31 jervell and lange-nielsen syndrome 10.8 CAV3 KCNH2 KCNQ1 SCN5A SNTA1
32 hairy cell leukemia 10.8 CAV3 KCNH2 KCNQ1 SCN5A SNTA1
33 paranoid personality disorder 10.8 HTR1A HTR2A
34 sudden infant death with dysgenesis of the testes syndrome 10.8
35 keratosis 10.8 HTR1A HTR2A SLC6A4
36 pigment dispersion syndrome 10.8 KCNH2 KCNQ1 SCN5A
37 laryngeal adductor paralysis 10.8 HTR1A HTR2A SLC6A4
38 postencephalitic parkinson disease 10.8 HTR1A HTR2A SLC6A4
39 polyneuropathy 10.8 HTR1A HTR2A
40 hypoglycemic coma 10.8 HTR1A HTR2A SLC6A4
41 spinal meningioma 10.8 CHAT HTR2A PHOX2B
42 cecal benign neoplasm 10.8 HTR1A HTR2A SLC6A4
43 partial motor epilepsy 10.8 HTR1A HTR2A SLC6A4 TH
44 hyperphosphatemia 10.8 CAV3 GPD1L KCNH2 KCNJ8 KCNQ1 SCN5A
45 bladder flat intraepithelial lesion 10.8 HTR1A HTR2A SLC6A4
46 hodgkin's granuloma 10.8 HTR1A HTR2A
47 acute poisoning by drugs with membrane-stabilizing effect 10.8 KCNH2 KCNQ1
48 hereditary multiple exostoses 10.7 ADCYAP1 HTR2A SLC6A4
49 hepatic angiomyolipoma 10.7 CHAT HTR2A SLC6A4 TH
50 albinism, oculocutaneous, type v 10.7 ADCYAP1 HTR1A HTR2A SLC6A4

Graphical network of the top 20 diseases related to Sudden Infant Death Syndrome:



Diseases related to Sudden Infant Death Syndrome

Symptoms & Phenotypes for Sudden Infant Death Syndrome

Symptoms via clinical synopsis from OMIM:

54

Resp:
periodic apnea

Misc:
malignant hyperthermia association
sudden infant death


Clinical features from OMIM:

272120

Human phenotypes related to Sudden Infant Death Syndrome:

32
id Description HPO Frequency HPO Source Accession
1 apneic episodes in infancy 32 HP:0005949

MGI Mouse Phenotypes related to Sudden Infant Death Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.15 PHOX2B SCN5A SLC6A4 SNTA1 TH ADCYAP1
2 cardiovascular system MP:0005385 10.1 HTR1A KCNH2 KCNJ8 KCNQ1 PHOX2B SCN5A
3 homeostasis/metabolism MP:0005376 10.1 ACADM ADCYAP1 CAV3 CHAT EN1 FEV
4 mortality/aging MP:0010768 9.93 ACADM ADCYAP1 CHAT EN1 FEV HTR1A
5 muscle MP:0005369 9.7 ACADM ADCYAP1 CAV3 CHAT EN1 HTR2A
6 nervous system MP:0003631 9.36 ADCYAP1 CHAT EN1 FEV HTR1A KCNQ1

Drugs & Therapeutics for Sudden Infant Death Syndrome

Drugs for Sudden Infant Death Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Autonomic Agents Phase 2, Phase 3
2 Neurotransmitter Agents Phase 2, Phase 3
3 Peripheral Nervous System Agents Phase 2, Phase 3
4
Nicotine Approved Phase 2 54-11-5 942 89594
5 Central Nervous System Stimulants Phase 2
6 Cholinergic Agents Phase 2
7 Nicotinic Agonists Phase 2
8
Varenicline Approved, Investigational 249296-44-4 5310966
9
Serotonin 50-67-9 5202

Interventional clinical trials:

(show all 31)

id Name Status NCT ID Phase Drugs
1 Influence of Pacifiers on Breastfeeding Duration Completed NCT00306956 Phase 3
2 Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial Withdrawn NCT00293735 Phase 2, Phase 3 labetalol (seizure prevention);MgSO4 (seizure prevention)
3 Effectiveness of Nicotine Replacement Therapy in Reducing the Risk of Nicotine Exposure in Pregnant Minority Smokers Completed NCT00341432 Phase 2
4 Is Home Positioning Time Associated With Torticollis Rate of Recovery? Completed NCT00347334 Phase 1
5 Do Pacifiers Protect From Sudden Infant Death Syndrome (SIDS) Through an Increase in Upper Airway Patency? Unknown status NCT01120938
6 Optimizing Technology-Delivered Interventions for Smoking in Pregnancy: The Mommy Check-Up Study. Unknown status NCT02340624
7 Factors Influencing the Racial Disparity in Sudden Infant Death Syndrome (SIDS) Completed NCT01361893
8 Incidence and Severity of Cardiorespiratory Events in Infants at Increased Epidemiological Risk for Sudden Infant Death Syndrome (SIDS) Completed NCT00004392
9 Parental Knowledge and Beliefs About Infant Sleep Position Completed NCT00005567
10 Comparing Children's Book to Brochures for Safe Sleep Education in a Home Visiting Program Completed NCT02376673
11 Enhancing Safe Sleep Practices of Urban Low-Income Mothers Completed NCT03070639
12 Reduce African-American Infant Mortality Completed NCT01361880
13 Study of the Impact of Parental Note Taking on the Effectiveness of Anticipatory Guidance Completed NCT01014169
14 Magnetic Resonance Imaging Autopsy Study Completed NCT01417962
15 Pilot Study of Novel Postpartum Educational Video Intervention Completed NCT02267265
16 Validation of a Non Invasive Blood Marker of SIDS and Vagal Disorders Completed NCT01358461
17 Impact of Smoke-free Legislation on Early-life Mortality and Low Birth Weight in England Completed NCT02039583
18 PRIDE: Preventing Respiratory Illnesses During Childhood Study Completed NCT00927264
19 Reducing Environmental Tobacco Smoke in Neonatal Intensive Care Unit (NICU) Infants' Homes Completed NCT00670280
20 Secondhand Smoke Exposure Reduction Among Young Children in China Completed NCT00995254
21 "Anticipatory Guidance in the Nursery and Its Impact on Non-urgent Emergency Department Visits" Completed NCT01859065
22 Characterization of Sweat Gland Function in Patients With Recessively Inherited Hypohidrotic Ectodermal Dysplasia Completed NCT01109290
23 Re-enforcing Safe Sleep Practices for Caregivers With Tangible Incentives Completed NCT02010450
24 Assessing the Impact of Smoke-free Legislation on Perinatal Health in the Netherlands Completed NCT02189265
25 Varenicline Pregnancy Cohort Study Completed NCT01290445 varenicline
26 Generations in Families Talking Safe Sleep Recruiting NCT03186469
27 Brainstem and Prematurity Recruiting NCT02669056
28 The Paediatric Virtual Autopsy Trial Recruiting NCT01888380
29 Baby Nutrition and Physical Activity Self-Assessment for Child Care (NAP SACC) Intervention Study Active, not recruiting NCT01890681
30 Changes in Sleep Patterns and Stress in Infants Entering Child Care Enrolling by invitation NCT01265277
31 Apparent Life Threatening Events, Sudden Infant Death Syndrome and Muscarinic Receptors Not yet recruiting NCT03278977

Search NIH Clinical Center for Sudden Infant Death Syndrome

Cochrane evidence based reviews: sudden infant death

Genetic Tests for Sudden Infant Death Syndrome

Genetic tests related to Sudden Infant Death Syndrome:

id Genetic test Affiliating Genes
1 Sudden Infant Death Syndrome 29

Anatomical Context for Sudden Infant Death Syndrome

MalaCards organs/tissues related to Sudden Infant Death Syndrome:

39
Brain, Heart, Lung, Testes, Liver, Hypothalamus, Pituitary

Publications for Sudden Infant Death Syndrome

Articles related to Sudden Infant Death Syndrome:

(show top 50) (show all 667)
id Title Authors Year
1
Beyond "Back to Sleep": Ways to Further Reduce the Risk of Sudden Infant Death Syndrome. ( 28806464 )
2017
2
Post-mortem whole-exome analysis in a large sudden infant death syndrome cohort with a focus on cardiovascular and metabolic genetic diseases. ( 28074886 )
2017
3
Ambient Temperature and Sudden Infant Death Syndrome in the United States. ( 28661937 )
2017
4
Infant pacifiers for reduction in risk of sudden infant death syndrome. ( 28378502 )
2017
5
Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptor 1 (PAC1) in the human infant brain and changes in the Sudden Infant Death Syndrome (SIDS). ( 28392470 )
2017
6
Low cerebrospinal fluid hypocretin levels during sudden infant death syndrome (SIDS) risk period. ( 28449906 )
2017
7
Sudden infant death syndrome due to long QT syndrome: a brief review of the genetic substrate and prevalence. ( 28316956 )
2017
8
Tricuspid Valve Hemangioma Associated with Hypoplastic Left Heart Syndrome Presenting as Sudden Infant Death Syndrome. ( 28272668 )
2017
9
High serum serotonin in sudden infant death syndrome. ( 28674018 )
2017
10
Targeted Metabolic Profiling of Post-Mortem Brain from Infants Who Died from Sudden Infant Death Syndrome. ( 28608686 )
2017
11
In-utero exposure to nicotine alters the development of the rabbit cardiac conduction system and provides a potential mechanism for sudden infant death syndrome. ( 28593499 )
2017
12
Reducing the Risk of Sudden Infant Death Syndrome. ( 28166332 )
2017
13
Paediatricians' Practice About SUDDEN Infant Death Syndrome in Catalonia, Spain. ( 28160232 )
2017
14
Sudden infant death syndrome and inherited cardiac conditions. ( 28880023 )
2017
15
Abnormalities in substance P neurokinin-1 receptor binding in key brainstem nuclei in sudden infant death syndrome related to prematurity and sex. ( 28931039 )
2017
16
The gene encoding the inwardly rectifying potassium channel Kir4.1 may be involved in sudden infant death syndrome. ( 28520217 )
2017
17
Medullary Serotonin Neuron Abnormalities in an Australian Cohort of Sudden Infant Death Syndrome. ( 28922849 )
2017
18
Area-based study shows most parents follow advice to reduce risk of sudden infant death syndrome. ( 27992061 )
2016
19
Promotion of the Unfolding Protein Response in Orexin/Dynorphin Neurons in Sudden Infant Death Syndrome (SIDS): Elevated pPERK and ATF4 Expression. ( 27796753 )
2016
20
Sudden infant death syndrome caused by cardiac arrhythmias: only a matter of genes encoding ion channels? ( 26872470 )
2016
21
Impaired orexin receptor expression in the KAPlliker-Fuse nucleus in sudden infant death syndrome: possible involvement of this nucleus in arousal pathophysiology. ( 27353953 )
2016
22
Altered gene expression and possible immunodeficiency in cases of sudden infant death syndrome. ( 26959483 )
2016
23
Inner ear lesion and the differential roles of hypoxia and hypercarbia in triggering active movements: Potential implication for the Sudden Infant Death Syndrome. ( 27634772 )
2016
24
Medullary mediation of the laryngeal adductor reflex: A possible role in sudden infant death syndrome. ( 26774498 )
2016
25
Swaddling and the Risk of Sudden Infant Death Syndrome: A Meta-analysis. ( 27244847 )
2016
26
A "Wear and Tear" Hypothesis to Explain Sudden Infant Death Syndrome. ( 27840622 )
2016
27
Maternal and obstetrical predictors of sudden infant death syndrome (SIDS). ( 27734747 )
2016
28
The Disappearance of Sudden Infant Death Syndrome: Has the Clock Turned Back? ( 26833064 )
2016
29
Metabolomic profiling of brain from infants who died from Sudden Infant Death Syndrome reveals novel predictive biomarkers. ( 27608295 )
2016
30
Sudden Infant Death Syndrome - Role of Trigeminocardiac Reflex: A Review. ( 27994573 )
2016
31
Sudden infant death syndrome: exposure to cigarette smoke leads to hypomethylation upstream of the growth factor independent 1 (GFI1) gene promoter. ( 27677632 )
2016
32
Sudden infant death syndrome: no significant expression of heat-shock proteins (HSP27, HSP70). ( 26662848 )
2016
33
Aspiring to inspire - serotonin, the laryngeal chemoreflex and the sudden infant death syndrome. ( 27368108 )
2016
34
Perinatal Fluoxetine Exposure Impairs the CO2 Chemoreflex: Implications for Sudden Infant Death Syndrome. ( 27018763 )
2016
35
Environmental risk factors for sudden infant death syndrome in Japan. ( 27664161 )
2016
36
Nurses' Knowledge and Adherence To Sudden Infant Death Syndrome Prevention Guidelines. ( 27019936 )
2016
37
Candidate gene variants of the immune system and sudden infant death syndrome. ( 26975745 )
2016
38
Hypothesis on supine sleep, sudden infant death syndrome reduction and association with increasing autism incidence. ( 27610351 )
2016
39
Evolution and significance of the triple risk model in sudden infant death syndrome. ( 28028890 )
2016
40
Comment on Fard et al.'s Candidate gene variants of the immune system and sudden infant death syndrome. ( 27188625 )
2016
41
The Disappearance of Sudden Infant Death Syndrome. ( 27571448 )
2016
42
The Disappearance of Sudden Infant Death Syndrome-Reply. ( 27571548 )
2016
43
Proteomic MALDI-TOF/TOF-IMS examination of peptide expression in the formalin fixed brainstem and changes in sudden infant death syndrome infants. ( 26926438 )
2016
44
Risk Factors, Protective Factors, and Current Recommendations to Reduce Sudden Infant Death Syndrome: A Review. ( 27918760 )
2016
45
Synaptogenesis and Myelination in the Nucleus/Tractus Solitarius: Potential Role in Apnea of Prematurity, Congenital Central Hypoventilation, and Sudden Infant Death Syndrome. ( 26661483 )
2016
46
Sudden infant death syndrome. ( 26034855 )
2015
47
Incidence and determinants of sudden infant death syndrome: a population-based study on 37 million births. ( 25447630 )
2015
48
Decreased orexin (hypocretin) immunoreactivity in the hypothalamus and pontine nuclei in sudden infant death syndrome. ( 25953524 )
2015
49
That's not it, either-neither polymorphisms in PHOX2B nor in MIF are involved in sudden infant death syndrome (SIDS). ( 26104808 )
2015
50
Undiagnosed metabolic dysfunction and sudden infant death syndrome--a case-control study. ( 25689231 )
2015

Variations for Sudden Infant Death Syndrome

UniProtKB/Swiss-Prot genetic disease variations for Sudden Infant Death Syndrome:

71 (show all 11)
id Symbol AA change Variation ID SNP ID
1 CAV3 p.Val14Leu VAR_043694 rs121909281
2 CAV3 p.Thr78Met VAR_043695 rs72546668
3 CAV3 p.Leu79Arg VAR_043696 rs121909282
4 GPD1L p.Glu83Lys VAR_044044 rs72552292
5 GPD1L p.Ile124Val VAR_044045 rs72552293
6 GPD1L p.Arg273Cys VAR_044046 rs72552294
7 KCNJ8 p.Val346Ile VAR_065879 rs147316959
8 SCN5A p.Ser1333Tyr VAR_036666 rs199473604
9 SCN5A p.Phe532Cys VAR_055177 rs199473573
10 SCN5A p.Gly1084Ser VAR_055185 rs199473190
11 SCN5A p.Phe1705Ser VAR_055207 rs199473627

ClinVar genetic disease variations for Sudden Infant Death Syndrome:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 SCN5A NM_198056.2(SCN5A): c.3308C> A (p.Ser1103Tyr) single nucleotide variant risk factor rs7626962 GRCh37 Chromosome 3, 38620907: 38620907
2 MT-TL1 m.3290T> C single nucleotide variant Pathogenic rs199474665 GRCh38 Chromosome MT, 3290: 3290
3 MT-ND1 m.3308T> G single nucleotide variant Pathogenic rs28358582 GRCh37 Chromosome MT, 3308: 3308
4 KCNH2 NM_000238.3(KCNH2): c.2860C> T (p.Arg954Cys) single nucleotide variant Likely pathogenic rs141401803 GRCh37 Chromosome 7, 150644799: 150644799

Expression for Sudden Infant Death Syndrome

Search GEO for disease gene expression data for Sudden Infant Death Syndrome.

Pathways for Sudden Infant Death Syndrome

GO Terms for Sudden Infant Death Syndrome

Cellular components related to Sudden Infant Death Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 voltage-gated potassium channel complex GO:0008076 9.33 KCNH2 KCNJ8 KCNQ1
2 caveola GO:0005901 9.13 CAV3 HTR2A SCN5A
3 sarcolemma GO:0042383 8.92 CAV3 KCNJ8 SCN5A SNTA1

Biological processes related to Sudden Infant Death Syndrome according to GeneCards Suite gene sharing:

(show all 35)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.97 HTR2A MT-ND1 SLC6A4 TH
2 regulation of ion transmembrane transport GO:0034765 9.85 KCNH2 KCNJ8 KCNQ1 SCN5A
3 cellular response to drug GO:0035690 9.8 KCNH2 KCNQ1 TH
4 memory GO:0007613 9.77 HTR2A SLC6A4 TH
5 social behavior GO:0035176 9.71 EN1 SLC6A4 TH
6 cardiac conduction GO:0061337 9.7 KCNH2 KCNQ1 SCN5A
7 cardiac muscle contraction GO:0060048 9.67 KCNH2 KCNQ1 SCN5A
8 regulation of sodium ion transmembrane transporter activity GO:2000649 9.66 CAV3 GPD1L
9 vasoconstriction GO:0042310 9.66 HTR1A SLC6A4
10 positive regulation of sodium ion transport GO:0010765 9.65 GPD1L SCN5A
11 positive regulation of potassium ion transmembrane transport GO:1901381 9.65 KCNH2 KCNQ1
12 behavior GO:0007610 9.65 HTR1A HTR2A
13 regulation of membrane repolarization GO:0060306 9.64 KCNH2 KCNQ1
14 negative regulation of potassium ion transport GO:0043267 9.63 ADCYAP1 HTR2A
15 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.63 KCNH2 KCNQ1
16 atrial cardiac muscle cell action potential GO:0086014 9.62 KCNQ1 SCN5A
17 regulation of behavior GO:0050795 9.61 HTR1A HTR2A
18 negative regulation of potassium ion transmembrane transport GO:1901380 9.61 CAV3 KCNH2
19 regulation of heart rate by cardiac conduction GO:0086091 9.61 KCNH2 KCNQ1 SCN5A
20 potassium ion export GO:0071435 9.6 KCNH2 KCNQ1
21 regulation of sodium ion transmembrane transport GO:1902305 9.58 SCN5A SNTA1
22 brainstem development GO:0003360 9.58 PHOX2B SCN5A
23 regulation of heart contraction GO:0008016 9.58 CAV3 KCNQ1 TH
24 regulation of hormone secretion GO:0046883 9.57 HTR1A HTR2A
25 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.56 KCNQ1 SCN5A
26 neurotransmitter biosynthetic process GO:0042136 9.54 CHAT SLC6A4 TH
27 membrane repolarization during action potential GO:0086011 9.51 KCNH2 KCNQ1
28 regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 9.5 CAV3 GPD1L SCN5A
29 serotonin receptor signaling pathway GO:0007210 9.48 HTR1A HTR2A
30 potassium ion export across plasma membrane GO:0097623 9.46 KCNH2 KCNQ1
31 regulation of heart rate GO:0002027 9.46 CAV3 GPD1L SCN5A SNTA1
32 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.43 KCNH2 KCNJ8 KCNQ1
33 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.35 CAV3 KCNH2 KCNQ1 SCN5A SNTA1
34 membrane repolarization GO:0086009 9.34 KCNQ1
35 ventricular cardiac muscle cell action potential GO:0086005 9.1 CAV3 GPD1L KCNH2 KCNQ1 SCN5A SNTA1

Molecular functions related to Sudden Infant Death Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.62 KCNH2 KCNJ8 KCNQ1 SCN5A
2 scaffold protein binding GO:0097110 9.54 KCNH2 KCNQ1 SCN5A
3 delayed rectifier potassium channel activity GO:0005251 9.48 KCNH2 KCNQ1
4 inward rectifier potassium channel activity GO:0005242 9.46 KCNH2 KCNJ8
5 serotonin binding GO:0051378 9.43 HTR1A HTR2A
6 sodium channel regulator activity GO:0017080 9.43 CAV3 GPD1L SNTA1
7 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 9.4 KCNH2 KCNQ1
8 ion channel binding GO:0044325 9.35 CAV3 GPD1L KCNQ1 SCN5A SNTA1
9 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 9.33 KCNH2 KCNJ8 KCNQ1
10 nitric-oxide synthase binding GO:0050998 8.92 CAV3 SCN5A SLC6A4 SNTA1

Sources for Sudden Infant Death Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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