MCID: SDD001
MIFTS: 62

Sudden Infant Death Syndrome malady

Genetic diseases, Rare diseases categories

Aliases & Classifications for Sudden Infant Death Syndrome

About this section

Aliases & Descriptions for Sudden Infant Death Syndrome:

Name: Sudden Infant Death Syndrome 46 8 42 10 44 32 2 61
Sids 8 42 2
Sudden Infant Death Syndrome, Susceptibility to 9 22
Sudden Death of Nonspecific Cause in Infancy 8
 
Sudden Infant Death Syndrome Nos 8
Crib Death 8
Cot Death 8


Classifications:



External Ids:

OMIM46 272120
Disease Ontology8 DOID:9007
NCIt39 C85173
MeSH33 D013398
ICD9CM27 798.0
ICD1025 R95

Summaries for Sudden Infant Death Syndrome

About this section
MedlinePlus:32 Sudden infant death syndrome (sids) is the sudden, unexplained death of an infant younger than one year old. some people call sids "crib death" because many babies who die of sids are found in their cribs. sids is the leading cause of death in children between one month and one year old. most sids deaths occur when babies are between two months and four months old. premature babies, boys, african americans, and american indian/alaska native infants have a higher risk of sids. although health care professionals don't know what causes sids, they do know ways to reduce the risk. these include placing babies on their backs to sleep, even for short naps. "tummy time" is for when babies are awake and someone is watching using a firm sleep surface, such as a crib mattress covered with a fitted sheet keeping soft objects and loose bedding away from sleep area making sure babies don't get too hot. keep the room at a comfortable temperature for an adult. don't smoke during pregnancy or allow anyone to smoke near your baby nih: national institute of child health and human development

MalaCards based summary: Sudden Infant Death Syndrome, also known as sids, is related to long qt syndrome and brugada syndrome, and has symptoms including apneic episodes in infancy An important gene associated with Sudden Infant Death Syndrome is SCN5A (sodium channel, voltage-gated, type V, alpha subunit), and among its related pathways are Antiarrhythmic Pathway, Pharmacodynamics and beta-Alanine metabolism. The compounds flecainide and clofilium have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and lung, and related mouse phenotypes are normal and muscle.

Disease Ontology:8 A syndrome that is characterized by the sudden death of an infant that is not predicted by medical history and remains unexplained after a thorough forensic autopsy and detailed death scene investigation.

OMIM:46 Sudden infant death syndrome (SIDS) is a diagnosis of exclusion which should be made only after a thorough autopsy... (272120) more...

Wikipedia:64 Sudden infant death syndrome (SIDS), also known as cot death or crib death, is the sudden unexplained... more...

Related Diseases for Sudden Infant Death Syndrome

About this section

Diseases in the Sudden Infant Death Syndrome family:

Cav3-Related Sudden Infant Death Syndrome

Diseases related to Sudden Infant Death Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1long qt syndrome31.1CAV3, SNTA1, SCN5A, KCNH2, KCNQ1
2brugada syndrome30.9GPD1L, SCN5A, KCNH2
3medium-chain acyl-coenzyme a dehydrogenase deficiency30.8ACADM, ACADS
4neuronitis10.8
5hypoxia10.7
6brugada syndrome 110.5SCN5A
7infant botulism10.5
8botulism10.5
9laryngitis10.5
10lactic acidosis10.5G6PC
11atrioventricular block10.4SCN5A, KCNH2
12hyperekplexia10.4
13cav3-related sudden infant death syndrome10.4
14central hypoventilation syndrome, congenital10.4PHOX2B
15acyl-coa dehydrogenase, short-chain, deficiency of10.4ACADM, ACADS
16organic acidemia10.4ACADS, ACADM
17spinocerebellar ataxia10.4SCN5A, ACADM, KCNH2
18hypophosphatemia10.4
19cerebritis10.4
20toxic shock syndrome10.4
21reye syndrome10.4
22myocarditis10.4
23pneumonia10.4
24hypoglycemia10.3G6PC, ACADM, ACADS
25myopathy10.2KCNH2, ACADS, CAV3
26asthma10.2
27orthostatic intolerance10.2
28ectodermal dysplasia10.2
29hepatitis10.2
30bronchiolitis10.2
31parametritis10.2
32desquamative interstitial pneumonia10.2
33munchausen by proxy10.2
34nasopharyngitis10.2
35hypertrophic pyloric stenosis10.2
36diphtheria10.2
37fetal alcohol syndrome10.2
38short qt syndrome10.2
39embryonal rhabdomyosarcoma10.2
40eosinophilia10.2
41influenza10.2
42ischemia10.2
43legionellosis10.2
44mediastinitis10.2
45meningitis10.2
46opiate dependence10.2
47pertussis10.2
48prostatitis10.2
49pulmonary eosinophilia10.2
50pyloric stenosis10.2

Graphical network of the top 20 diseases related to Sudden Infant Death Syndrome:



Diseases related to sudden infant death syndrome

Symptoms for Sudden Infant Death Syndrome

About this section

Symptoms by clinical synopsis from OMIM:

272120

Clinical features from OMIM:

272120

HPO human phenotypes related to Sudden Infant Death Syndrome:

id Description Frequency HPO Source Accession
1 apneic episodes in infancy HP:0005949

Drugs & Therapeutics for Sudden Infant Death Syndrome

About this section

Drug clinical trials:

Search ClinicalTrials for Sudden Infant Death Syndrome

Search NIH Clinical Center for Sudden Infant Death Syndrome

Genetic Tests for Sudden Infant Death Syndrome

About this section

Genetic tests related to Sudden Infant Death Syndrome:

id Genetic test Affiliating Genes
1 Sudden Infant Death Syndrome22

Anatomical Context for Sudden Infant Death Syndrome

About this section

MalaCards organs/tissues related to Sudden Infant Death Syndrome:

31
Brain, Heart, Lung, Breast, Liver, Testes, Eye, Whole blood, Smooth muscle, Colon, Placenta, Prostate, Endothelial, Hypothalamus, Medulla oblongata, Pituitary

Animal Models for Sudden Infant Death Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Sudden Infant Death Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028739.2SLC6A4, PHOX2B, G6PC, SCN5A, KCNQ1, EN1
2MP:00053699.2KCNH2, SCN5A, ACADS, SNTA1, CAV3, SLC6A4
3MP:00036318.7PHOX2B, SNTA1, G6PC, SCN5A, IDS, KCNQ1
4MP:00053858.7ACADM, SLC6A4, PHOX2B, EN1, CAV3, SCN5A
5MP:00053868.6IDS, KCNQ1, SCN5A, G6PC, ACADS, SNTA1
6MP:00053788.6IDS, SCN5A, G6PC, EN1, SLC6A4, PHOX2B
7MP:00053768.2EN1, CAV3, PHOX2B, SLC6A4, SNTA1, ACADS
8MP:00107688.2IDS, SCN5A, EN1, ACADM, SLC6A4, ACADS

Publications for Sudden Infant Death Syndrome

About this section

Articles related to Sudden Infant Death Syndrome:

(show top 50)    (show all 594)
idTitleAuthorsYear
1
Does I^-APP staining of the brain in infant bed-sharing deaths differentiate these cases from sudden infant death syndrome? (25287799)
2014
2
Sudden Infant Death Syndrome (SIDS) risk reduction and infant sleep location - moving the discussion forward. (22571891)
2013
3
Functional single-nucleotide variant of HSPD1 in sudden infant death syndrome. (23823174)
2013
4
Sudden infant death syndrome: cry characteristics. (23759336)
2013
5
A re-audit of the use of definitions of sudden infant death syndrome (SIDS) in peer-reviewed literature. (23084308)
2012
6
Temporal trends in sudden infant death syndrome in Canada from 1991 to 2005: contribution of changes in cause of death assignment practices and in maternal and infant characteristics. (22324498)
2012
7
Review finds that bed sharing increases risk of sudden infant death syndrome. (22561148)
2012
8
Do infants die of sudden infant death syndrome (SIDS) with long QT syndrome (LQTS) or from LQTS? (22868671)
2012
9
Reanalyses of case-control studies examining the temporal association between sudden infant death syndrome and vaccination. (22289512)
2012
10
Cardiac ion channelopathies and the sudden infant death syndrome. (23304551)
2012
11
Prenatal nicotine exposure in rhesus monkeys compromises development of brainstem and cardiac monoamine pathways involved in perinatal adaptation and sudden infant death syndrome: amelioration by vitamin C. (21320590)
2011
12
Formative evaluation to improve prevention of sudden infant death syndrome (SIDS): a prospective study. (21517963)
2011
13
Serotonin in the sudden infant death syndrome. (21152449)
2010
14
Cardiac muscarinic receptor overexpression in sudden infant death syndrome. (20209124)
2010
15
Outcomes of heart transplantation using donor hearts from infants with sudden infant death syndrome. (20691612)
2010
16
Association of dopamine transporter and monoamine oxidase molecular polymorphisms with sudden infant death syndrome and stillbirth: new insights into the serotonin hypothesis. (18810510)
2009
17
The role of infection and inflammation in sudden infant death syndrome. (19874217)
2009
18
Sudden infant death syndrome (SIDS) in African Americans: polymorphisms in the gene encoding the stress peptide pituitary adenylate cyclase-activating polypeptide (PACAP). (19120039)
2009
19
Minimizing the risks of sudden infant death syndrome: to swaddle or not to swaddle? (19540517)
2009
20
Sudden infant death syndrome: a developmental psychobiologist's perspective. (19206137)
2009
21
Genes regulating the serotonin metabolic pathway in the brain stem and their role in the etiopathogenesis of the sudden infant death syndrome. (18387780)
2008
22
Sleep position alters arousal processes maximally at the high-risk age for sudden infant death syndrome. (19090953)
2008
23
The effect of maternal smoking and drinking during pregnancy upon (3)H-nicotine receptor brainstem binding in infants dying of the sudden infant death syndrome: initial observations in a high risk population. (17924983)
2008
24
Intrathoracic petechial hemorrhages in sudden infant death syndrome and other infant deaths: time for re-examination. (18416633)
2008
25
Cytomegalovirus-induced pneumonia and myocarditis in three cases of suspected sudden infant death syndrome (SIDS): diagnosis by immunohistochemical techniques and molecularpathologic methods. (17566679)
2008
26
Sudden infant death syndrome and activating GNAS1 gene mutations. (18075835)
2007
27
Cribs for Kids: risk and reduction of sudden infant death syndrome and accidental suffocation. (17896680)
2007
28
Letter by O'Rourke regarding articles, "Prevalence of long-QT syndrome gene variants in sudden infant death syndrome," "Cardiac sodium channel dysfunction in sudden infant death syndrome," and "Contribution of long-QT syndrome genes to sudden infant death syndrome: is it time to consider newborn electrocardiographic screening?". (17646591)
2007
29
Hemoglobin F in sudden infant death syndrome: a San Diego SIDS/SUDC Research Project report. (17961870)
2007
30
Mechanisms of pathogenesis in the Sudden Infant Death Syndrome. (17644048)
2007
31
Sudden infant death syndrome. (17452672)
2007
32
Educating parents about the risk factors of sudden infant death syndrome: the role of neonatal intensive care unit and well baby nursery nurses. (17505237)
2007
33
Contribution of long-QT syndrome genes to sudden infant death syndrome: is it time to consider newborn electrocardiographic screening? (17242294)
2007
34
Sudden infant death syndrome. (17980736)
2007
35
Predicting the risk of sudden infant death syndrome from obstetric characteristics. (16396879)
2006
36
New recommendations to reduce the risk of sudden infant death syndrome. (16523040)
2006
37
Effects of prematurity on heart rate control: implications for sudden infant death syndrome. (16716094)
2006
38
Sudden Infant Death Syndrome and prenatal maternal smoking: rising attributed risk in the Back to Sleep era. (15644131)
2005
39
Fatty acid oxidation disorder as a cause of sudden infant death syndrome (SIDS)--a case report. (16366103)
2005
40
Sudden Infant Death Syndrome: increased carotid-body dopamine and noradrenaline content. (16034653)
2005
41
Mortality due to sudden infant death syndrome in Northern Italy, 1990-2000: a baseline for the assessment of prevention campaigns. (15367320)
2004
42
Genes and Sudden Infant Death Syndrome. (15240865)
2004
43
Possible pathomechanisms of sudden infant death syndrome: key role of chronic hypoxia, infection/inflammation states, cytokine irregularities, and metabolic trauma in genetically predisposed infants. (15543094)
2004
44
Adult hemoglobin levels at birth and risk of sudden infant death syndrome. (15066877)
2004
45
Sudden infant death syndrome is not associated with the mutation of PHOX2B gene, a major causative gene of congenital central hypoventilation syndrome. (15185974)
2004
46
Transcutaneous implantation of an internal cardioverter defibrillator in a small infant with recurrent myocardial ischemia and cardiac arrest simulating sudden infant death syndrome. (14720167)
2004
47
Prenatal nicotine exposure alters central cardiorespiratory responses to hypoxia in rats: implications for sudden infant death syndrome. (15496661)
2004
48
Sudden infant death syndrome: is it a transepithelial transport disorder? (12323127)
2002
49
Frequency of 985A-to-G mutation in medium-chain acyl-CoA dehydrogenase gene among patients with sudden infant death syndrome, Reye syndrome, severe motor and intellectual disabilities and healthy newborns in Japan. (8840534)
1996
50
Desquamative interstitial pneumonia in an infant. Mimicry of sudden infant death syndrome. (2589300)
1989

Variations for Sudden Infant Death Syndrome

About this section

UniProtKB/Swiss-Prot genetic disease variations for Sudden Infant Death Syndrome:

63 (show all 11)
id Symbol AA change Variation ID SNP ID
1CAV3p.Val14LeuVAR_043694rs121909281
2CAV3p.Thr78MetVAR_043695rs72546668
3CAV3p.Leu79ArgVAR_043696
4GPD1Lp.Glu83LysVAR_044044
5GPD1Lp.Ile124ValVAR_044045rs72552293
6GPD1Lp.Arg273CysVAR_044046
7KCNJ8p.Val346IleVAR_065879
8SCN5Ap.Ser1333TyrVAR_036666
9SCN5Ap.Phe532CysVAR_055177
10SCN5Ap.Gly1084SerVAR_055185
11SCN5Ap.Phe1705SerVAR_055207

Clinvar genetic disease variations for Sudden Infant Death Syndrome:

5 (show all 19)
id Gene Variation Type Significance SNP ID Assembly Location
1KCNQ1NM_000218.2(KCNQ1): c.1135T> C (p.Trp379Arg)single nucleotide variantPathogenicrs199472768GRCh37Chr 11, 2608806: 2608806
2KCNQ1NM_000218.2(KCNQ1): c.1750G> A (p.Gly584Ser)single nucleotide variantPathogenicrs199472811GRCh37Chr 11, 2799223: 2799223
3KCNQ1NM_000218.2(KCNQ1): c.1793A> G (p.Lys598Arg)single nucleotide variantPathogenicrs199472817GRCh37Chr 11, 2799266: 2799266
4KCNH2NM_000238.3(KCNH2): c.2684C> T (p.Thr895Met)single nucleotide variantPathogenicrs199473434GRCh37Chr 7, 150645540: 150645540
5KCNH2NM_000238.3(KCNH2): c.2860C> T (p.Arg954Cys)single nucleotide variantPathogenicrs141401803GRCh37Chr 7, 150644799: 150644799
6KCNH2NM_000238.3(KCNH2): c.3118A> G (p.Ser1040Gly)single nucleotide variantPathogenicrs199473024GRCh37Chr 7, 150644450: 150644450
7KCNH2NM_000238.3(KCNH2): c.3470C> T (p.Pro1157Leu)single nucleotide variantLikely pathogenicrs143167166GRCh37Chr 7, 150642463: 150642463
8KCNH2NM_000238.3(KCNH2): c.818G> A (p.Arg273Gln)single nucleotide variantPathogenicrs199472877GRCh37Chr 7, 150655245: 150655245
9KCNH2NM_000238.3(KCNH2): c.835G> A (p.Val279Met)single nucleotide variantPathogenicrs199472879GRCh37Chr 7, 150655228: 150655228
10KCNH2NM_000238.3(KCNH2): c.881G> T (p.Gly294Val)single nucleotide variantLikely pathogenicrs199473549GRCh37Chr 7, 150655182: 150655182
11SCN5ANM_000335.4(SCN5A): c.2039G> A (p.Arg680His)single nucleotide variantPathogenicrs199473142GRCh37Chr 3, 38639443: 38639443
12SCN5ANM_000335.4(SCN5A): c.3247G> A (p.Gly1083Ser)single nucleotide variantPathogenicrs199473190GRCh37Chr 3, 38620965: 38620965
13SCN5ANM_000335.4(SCN5A): c.4453T> C (p.Phe1485Leu)single nucleotide variantPathogenicrs199473615GRCh37Chr 3, 38597233: 38597233
14SCN5ANM_000335.4(SCN5A): c.5111T> C (p.Phe1704Ser)single nucleotide variantPathogenicrs199473627GRCh37Chr 3, 38592749: 38592749
15GPD1LNM_015141.3(GPD1L): c.370A> G (p.Ile124Val)single nucleotide variantLikely pathogenic, Pathogenicrs72552293GRCh37Chr 3, 32181723: 32181723
16SCN5ANM_000335.4(SCN5A): c.3305C> A (p.Ser1102Tyr)single nucleotide variantPathogenic, risk factorrs7626962GRCh37Chr 3, 38620907: 38620907
17MT-TL1m.3290T> Csingle nucleotide variantPathogenicrs199474665GRCh37Chr MT, 3290: 3290
18MT-ND1m.3308T> Csingle nucleotide variantPathogenicrs28358582GRCh37Chr MT, 3308: 3308
19MT-ND1m.3308T> Gsingle nucleotide variantPathogenicrs28358582GRCh37Chr MT, 3308: 3308

Expression for genes affiliated with Sudden Infant Death Syndrome

About this section
Search GEO for disease gene expression data for Sudden Infant Death Syndrome.

Pathways for genes affiliated with Sudden Infant Death Syndrome

About this section

Pathways related to Sudden Infant Death Syndrome according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9KCNH2, KCNQ1, KCNJ8, SCN5A
2
Show member pathways
phenylethylamine degradation I36
9.9ACADM, ECHS1
3
Show member pathways
9.9ECHS1, ACADM
4
Show member pathways
9.9ACADS, ECHS1
5
Show member pathways
9.8KCNH2, KCNQ1, KCNJ8, SLC6A4
6
Show member pathways
mitochondrial L-carnitine shuttle pathway36
Saturated fatty acid biosynthesis59
9.6ACADM, ACADS, ECHS1
7
Show member pathways
fatty acid beta-oxidation III (unsaturated, odd number)36
Fatty Acid Beta Oxidation36
9.6ACADM, ACADS, ECHS1
8
Show member pathways
L-serine degradation36
pentose phosphate pathway (oxidative branch)36
formaldehyde oxidation II (glutathione-dependent)36
9.6ECHS1, ACADS, ACADM
9
Show member pathways
beta-alanine degradation I36
valine degradation I36
pyruvate fermentation to lactate36
isoleucine degradation I36
9.6ECHS1, ACADS, ACADM
10
Show member pathways
9.5ACADM, ACADS, GPD1L, ECHS1
11
Show member pathways
8.9ECHS1, GPD1L, IDS, G6PC, MT-ND1, ACADS
127.5C4B, KCNH2, KCNQ1, KCNJ8, GPD1L, SCN5A

Compounds for genes affiliated with Sudden Infant Death Syndrome

About this section
Sources:
50PharmGKB, 44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB
See all sources

Compounds related to Sudden Infant Death Syndrome according to GeneCards Suite gene sharing:

(show all 45)
idCompoundScoreTop Affiliating Genes
1flecainide50 44 28 1113.6SCN5A, KCNH2
2clofilium44 2811.6KCNH2, KCNQ1
3propafenone28 44 50 1113.6SCN5A, KCNH2
4mexiletine50 44 1112.6SCN5A, KCNH2
5cocaethylene4410.6KCNH2, SLC6A4
6cromakalim44 2811.5KCNJ8, KCNQ1
7bepridil44 28 1112.5KCNH2, KCNQ1
8isoleucine4410.5KCNH2, KCNQ1, SCN5A
9katp4410.5KCNJ8, KCNQ1, KCNH2
10trazodone44 28 1112.4KCNH2, SLC6A4
11pentamidine44 1111.3KCNH2, G6PC
12FADH2410.3ACADS, ACADM
13cisapride44 28 1112.3KCNH2, SCN5A
14valine4410.3SLC6A4, MT-ND1, SCN5A, KCNH2
15verapamil44 28 50 24 1114.2SLC6A4, SCN5A, KCNH2
16cocaine44 1111.2KCNH2, SCN5A, SLC6A4
173-methylcrotonyl-coa44 2411.2ECHS1, ACADM
18potassium44 24 1112.2KCNH2, KCNQ1, KCNJ8, SCN5A
19Methacrylyl-CoA2410.1ACADS, ECHS1, ACADM
20nadh44 24 1112.1ACADS, MT-ND1, GPD1L, G6PC
21Tiglyl-CoA2410.1ECHS1, ACADS, ACADM
22bamhi4410.1ACADM, C4A
23hind iii4410.0C4A, IDS
24isoproterenol44 1111.0KCNQ1, KCNH2, CAV3
25(2E)-Decenoyl-CoA2410.0ACADS, ECHS1, ACADM
26(2E)-Octenoyl-CoA2410.0ECHS1, ACADS, ACADM
27(2E)-Dodecenoyl-CoA2410.0ACADM, ECHS1, ACADS
28(2E)-Tetradecenoyl-CoA2410.0ACADS, ECHS1, ACADM
29Crotonoyl-CoA2410.0ECHS1, ACADS, ACADM
30trans-2-Hexenoyl-CoA2410.0ECHS1, ACADM, ACADS
31Acrylyl-CoA2410.0ECHS1, ACADS, ACADM
32(2E)-Hexadecenoyl-CoA2410.0ACADM, ACADS, ECHS1
33lysine449.9ACADM, SLC6A4, KCNH2, SCN5A
34Heptanoyl-CoA249.9ACADS, ECHS1, ACADM
35sodium44 2410.9SLC6A4, CAV3, SNTA1, KCNH2, KCNQ1, SCN5A
36glutamine449.9SCN5A, G6PC, ACADM, PHOX2B
37alanine449.8G6PC, KCNH2, SCN5A, MT-ND1, PHOX2B, SLC6A4
38threonine449.8SCN5A, KCNH2, KCNQ1, MT-ND1, C4A, C4B
39FAD249.8ACADM, MT-ND1, ACADS
40steroid449.8C4B, C4A, G6PC, IDS, KCNH2
41riboflavin44 24 1111.7ACADM, ACADS
42fatty acid449.7CAV3, ACADM, ACADS, G6PC, ECHS1
43arginine449.6SCN5A, KCNQ1, KCNH2, G6PC, ACADM, SLC6A4
44calcium44 50 24 1112.4C4B, KCNQ1, IDS, CAV3, SCN5A, G6PC
45serine449.4C4A, SLC6A4, ACADS, KCNH2, SCN5A, C4B

GO Terms for genes affiliated with Sudden Infant Death Syndrome

About this section

Cellular components related to Sudden Infant Death Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated potassium channel complexGO:00080769.7KCNH2, KCNQ1, KCNJ8
2sarcolemmaGO:00423839.6CAV3, SNTA1, SCN5A, KCNJ8, KCNQ1
3plasma membraneGO:00058868.8KCNQ1, KCNJ8, GPD1L, SCN5A, CAV3, SLC6A4

Biological processes related to Sudden Infant Death Syndrome according to GeneCards Suite gene sharing:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1membrane depolarization during action potentialGO:008601010.5KCNH2, SCN5A
2regulation of atrial cardiac muscle cell membrane repolarizationGO:006037210.5KCNQ1, SCN5A
3negative regulation of potassium ion transmembrane transportGO:0190138010.5CAV3, KCNH2
4membrane repolarization during action potentialGO:008601110.5KCNQ1, KCNH2
5membrane repolarization during cardiac muscle cell action potentialGO:008601310.5KCNQ1, KCNH2
6positive regulation of potassium ion transmembrane transportGO:0190138110.4KCNQ1, KCNH2
7regulation of heart rate by cardiac conductionGO:008609110.4KCNH2, KCNQ1, SCN5A
8regulation of membrane repolarizationGO:006030610.4KCNH2, KCNQ1
9brainstem developmentGO:000336010.4PHOX2B, SCN5A
10cardiac muscle contractionGO:006004810.4KCNH2, KCNQ1, SCN5A
11regulation of sodium ion transmembrane transportGO:0190230510.4SNTA1, SCN5A
12regulation of ventricular cardiac muscle cell membrane depolarizationGO:006037310.4CAV3, SCN5A, GPD1L
13potassium ion exportGO:007143510.3KCNH2, KCNQ1
14regulation of sodium ion transmembrane transporter activityGO:0200064910.3CAV3, GPD1L
15fatty acid beta-oxidation using acyl-CoA dehydrogenaseGO:003353910.3ACADM, ACADS
16positive regulation of sodium ion transportGO:001076510.2GPD1L, SCN5A
17regulation of heart rateGO:000202710.2CAV3, SNTA1, GPD1L, SCN5A
18regulation of ventricular cardiac muscle cell membrane repolarizationGO:006030710.1KCNH2, KCNQ1, SCN5A, SNTA1, CAV3
19regulation of heart contractionGO:000801610.1CAV3, KCNQ1
20response to starvationGO:004259410.0ACADS, ACADM
21fatty acid beta-oxidationGO:000663510.0ACADS, ECHS1, ACADM
22regulation of complement activationGO:003044910.0C4A, C4B
23ventricular cardiac muscle cell action potentialGO:00860059.9SNTA1, KCNQ1, GPD1L, SCN5A, CAV3, KCNH2
24cellular lipid metabolic processGO:00442559.8ECHS1, GPD1L, ACADS, ACADM
25triglyceride metabolic processGO:00066419.8CAV3, G6PC
26small molecule metabolic processGO:00442819.2ECHS1, GPD1L, IDS, ACADS, ACADM, G6PC

Molecular functions related to Sudden Infant Death Syndrome according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationGO:0190228210.3KCNH2, KCNQ1
2inward rectifier potassium channel activityGO:000524210.2KCNJ8, KCNH2
3sodium channel regulator activityGO:001708010.1CAV3, SNTA1, GPD1L
4acyl-CoA dehydrogenase activityGO:000399510.1ACADM, ACADS
5nitric-oxide synthase bindingGO:005099810.0SLC6A4, CAV3, SNTA1, SCN5A
6endopeptidase inhibitor activityGO:000486610.0C4B, C4A
7calmodulin bindingGO:00055169.9KCNQ1, SCN5A, SNTA1
8scaffold protein bindingGO:00971109.9SCN5A, KCNQ1
9ion channel bindingGO:00443259.8KCNQ1, GPD1L, SCN5A, SNTA1, CAV3

Sources for Sudden Infant Death Syndrome

About this section
2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet