SIDS
MCID: SDD001
MIFTS: 61

Sudden Infant Death Syndrome (SIDS) malady

Categories: Genetic diseases, Rare diseases

Aliases & Classifications for Sudden Infant Death Syndrome

Aliases & Descriptions for Sudden Infant Death Syndrome:

Name: Sudden Infant Death Syndrome 54 12 50 66 29 52 41 3 3 3 14 69
Sids 12 50 66 3
Sudden Infant Death Syndrome, Susceptibility to 13
Sudden Death of Nonspecific Cause in Infancy 12
Sudden Infant Death Syndrome Nos 12
Sudden Infant Death 42
Crib Death 12
Cot Death 12

Characteristics:

HPO:

32
sudden infant death syndrome:
Mortality/Aging sudden death


Classifications:



External Ids:

OMIM 54 272120
Disease Ontology 12 DOID:9007
ICD9CM 35 798.0
MeSH 42 D013398
NCIt 47 C85173
MedGen 40 C0038644
ICD10 33 R95
UMLS 69 C0038644

Summaries for Sudden Infant Death Syndrome

MedlinePlus : 41 sudden infant death syndrome (sids) is the sudden, unexplained death of an infant younger than one year old. some people call sids "crib death" because many babies who die of sids are found in their cribs. sids is the leading cause of death in children between one month and one year old. most sids deaths occur when babies are between one month and four months old. premature babies, boys, african americans, and american indian/alaska native infants have a higher risk of sids. although health care professionals don't know what causes sids, they do know ways to reduce the risk. these include placing your baby on his or her back to sleep, even for short naps. "tummy time" is for when babies are awake and someone is watching having your baby sleep in your room for at least the first six months. your baby should sleep close to you, but on a separate surface designed for infants, such as a crib or bassinet. using a firm sleep surface, such as a crib mattress covered with a fitted sheet keeping soft objects and loose bedding away from your baby's sleep area breastfeeding your baby making sure that your baby doesn't get too hot. keep the room at a comfortable temperature for an adult. not smoking during pregnancy or allowing anyone to smoke near your baby nih: national institute of child health and human development

MalaCards based summary : Sudden Infant Death Syndrome, also known as sids, is related to sudden infant death with dysgenesis of the testes syndrome and cav3-related sudden infant death syndrome, and has symptoms including apneic episodes in infancy An important gene associated with Sudden Infant Death Syndrome is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Transmission across Chemical Synapses and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Nicotine and Autonomic Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and lung, and related phenotypes are behavior/neurological and cardiovascular system

Disease Ontology : 12 A syndrome that is characterized by the sudden death of an infant that is not predicted by medical history and remains unexplained after a thorough forensic autopsy and detailed death scene investigation.

NIH Rare Diseases : 50 sudden infant death syndrome (sids) is the unexpected, sudden death of a child under age 1 which cannot be explained after a thorough investigation is conducted. infants who are affected by the condition generally appear healthy with no suspicious signs and symptoms prior to the incident. it is the leading cause of death in infants age 1 to 12 months old. the exact underlying cause of sids is unknown; however, scientists suspect that it is likely a multifactorial condition (associated with the effects of multiple genes in combination with lifestyle and environmental factors). although there is no guaranteed way to prevent sids, the american academy of pediatrics has a published list of recommendations for risk reduction. please click on the link to access this resource. last updated: 12/15/2015

OMIM : 54 Sudden infant death syndrome (SIDS) is a diagnosis of exclusion which should be made only after a thorough autopsy... (272120) more...

UniProtKB/Swiss-Prot : 66 Sudden infant death syndrome: SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive.

Wikipedia : 71 Sudden infant death syndrome (SIDS), also known as cot death or crib death, is the sudden unexplained... more...

Related Diseases for Sudden Infant Death Syndrome

Diseases in the Sudden Infant Death Syndrome family:

Cav3-Related Sudden Infant Death Syndrome

Diseases related to Sudden Infant Death Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
id Related Disease Score Top Affiliating Genes
1 sudden infant death with dysgenesis of the testes syndrome 12.7
2 cav3-related sudden infant death syndrome 12.2
3 hyperekplexia 11.3
4 infantile apnea 11.2
5 reye syndrome 11.2
6 infantile histiocytoid cardiomyopathy 11.0
7 lipodystrophy, familial partial, type 5 10.4 CAV3 SCN5A SNTA1
8 migraine with aura 9 10.4 KCNH2 KCNQ1 SCN5A
9 brugada syndrome 1 10.4 KCNH2 KCNQ1 SCN5A
10 familial sick sinus syndrome 10.4 KCNH2 KCNQ1 SCN5A
11 isolated encephalocele 10.4 KCNH2 KCNQ1 SCN5A
12 keppen-lubinsky syndrome 10.4 KCNH2 KCNQ1 SCN5A
13 parkinson disease 20, early-onset 10.4 KCNH2 KCNQ1 SCN5A
14 developmental dysplasia of the hip 2 10.4 GPD1L SCN5A
15 adult brainstem astrocytoma 10.4 HTR1A MAOA SLC6A4
16 renpenning syndrome 10.4 HTR1A MAOA SLC6A4
17 specific language impairment 4 10.4 CAV3 KCNH2 KCNQ1 SCN5A
18 multicentric carpotarsal osteolysis syndrome 10.4 KCNH2 KCNQ1 SCN5A SNTA1
19 short qt syndrome 2 10.4 CAV3 KCNH2 KCNQ1 SCN5A
20 kidney pelvis papillary carcinoma 10.4 HTR1A MAOA SLC6A4
21 sick sinus syndrome 1 10.4 KCNH2 KCNQ1 SCN5A
22 neurogenic bladder 10.4 HTR2A MAOA SLC6A4
23 dry eye syndrome 10.4 HTR1A HTR2A SLC6A4
24 tinea pedis 10.4 HTR1A MAOA SLC6A4
25 pyromania 10.4 HTR2A MAOA SLC6A4
26 tardbp-related frontotemporal dementia 10.4 KCNH2 KCNQ1 SCN5A
27 chronic eosinophilic pneumonia 10.4 HTR1A MAOA SLC6A4
28 waardenburg's syndrome 10.4 HTR1A HTR2A SLC6A4
29 hypoglycemic coma 10.4 HTR1A HTR2A MAOA SLC6A4
30 cytomegalic congenital adrenal hypoplasia 10.4 HTR2A MAOA SLC6A4 TH
31 multiple personality disorder 10.4 HTR1A HTR2A MAOA SLC6A4
32 intrahepatic gall duct cancer 10.4 HTR2A MAOA SLC6A4
33 atrial fibrillation, familial, 3 10.4 CAV3 KCNH2 KCNQ1 SCN5A SNTA1
34 hepatitis b reinfection following liver transplantation 10.4 HTR1A HTR2A MAOA SLC6A4
35 postencephalitic parkinson disease 10.4 HTR1A HTR2A MAOA SLC6A4
36 hyperthyroxinemia 10.4 CAV3 KCNH2 KCNQ1 SCN5A SNTA1
37 third-degree atrioventricular block 10.4 KCNH2 KCNQ1 SCN5A
38 keratosis 10.4 HTR1A HTR2A MAOA SLC6A4
39 cecal benign neoplasm 10.4 HTR1A HTR2A MAOA SLC6A4
40 familial periodic paralysis 10.4 KCNH2 KCNQ1 SCN5A
41 lichen disease 10.3 HTR1A HTR2A MAOA SLC6A4
42 fechtner syndrome 10.3 HTR1A HTR2A MAOA SLC6A4
43 hereditary multiple exostoses 10.3 ADCYAP1 HTR2A MAOA SLC6A4
44 hepatitis d 10.3 HTR1A HTR2A MAOA SLC6A4
45 primary angle-closure glaucoma 10.3 HTR1A HTR2A SLC6A4
46 antley-bixler syndrome 10.3 CAV3 GPD1L KCNH2 KCNJ8 KCNQ1 SCN5A
47 retinoblastoma 10.3 HTR1A HTR2A MAOA SLC6A4
48 autosomal dominant nocturnal frontal lobe epilepsy 2 10.3 KCNH2 KCNQ1 SCN5A
49 polyneuropathy 10.3 HTR1A HTR2A
50 personality disorder 10.3 HTR1A HTR2A MAOA SLC6A4

Graphical network of the top 20 diseases related to Sudden Infant Death Syndrome:



Diseases related to Sudden Infant Death Syndrome

Symptoms & Phenotypes for Sudden Infant Death Syndrome

Symptoms by clinical synopsis from OMIM:

272120

Clinical features from OMIM:

272120

Human phenotypes related to Sudden Infant Death Syndrome:

32
id Description HPO Frequency HPO Source Accession
1 apneic episodes in infancy 32 HP:0005949

MGI Mouse Phenotypes related to Sudden Infant Death Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 ADCYAP1 CHAT EN1 HTR1A HTR2A KCNQ1
2 cardiovascular system MP:0005385 10.07 ACADM CAV3 CHAT EN1 HTR1A KCNH2
3 homeostasis/metabolism MP:0005376 10 ADCYAP1 CAV3 CHAT EN1 HTR1A KCNH2
4 muscle MP:0005369 9.7 ACADM ADCYAP1 CAV3 CHAT EN1 HTR2A
5 nervous system MP:0003631 9.36 HTR1A KCNQ1 MAOA ADCYAP1 CHAT EN1

Drugs & Therapeutics for Sudden Infant Death Syndrome

Drugs for Sudden Infant Death Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nicotine Approved Phase 4,Phase 2 54-11-5 942 89594
2 Autonomic Agents Phase 2, Phase 3,Phase 1
3 Neurotransmitter Agents Phase 2, Phase 3,Phase 1
4 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 1
5 Central Nervous System Stimulants Phase 2
6 Cholinergic Agents Phase 2
7 Nicotinic Agonists Phase 2
8
Varenicline Approved, Investigational 249296-44-4 5310966
9
Serotonin 50-67-9 5202
10 Anti-Bacterial Agents
11 Antibiotics, Antitubercular
12 Neurotransmitter Uptake Inhibitors
13 Serotonin Agents
14 Serotonin Uptake Inhibitors

Interventional clinical trials:

(show all 37)
id Name Status NCT ID Phase
1 PRIDE: Preventing Respiratory Illnesses During Childhood Study Completed NCT00927264 Phase 4
2 Influence of Pacifiers on Breastfeeding Duration Completed NCT00306956 Phase 3
3 Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial Withdrawn NCT00293735 Phase 2, Phase 3
4 Effectiveness of Nicotine Replacement Therapy in Reducing the Risk of Nicotine Exposure in Pregnant Minority Smokers Completed NCT00341432 Phase 2
5 Treatment Targets for Chronic Hypertension in Pregnancy Withdrawn NCT00194974 Phase 1, Phase 2
6 Is Home Positioning Time Associated With Torticollis Rate of Recovery? Completed NCT00347334 Phase 1
7 Do Pacifiers Protect From Sudden Infant Death Syndrome (SIDS) Through an Increase in Upper Airway Patency? Unknown status NCT01120938
8 Validation of a Non Invasive Blood Marker of SIDS and Vagal Disorders Unknown status NCT01358461
9 Optimizing Technology-Delivered Interventions for Smoking in Pregnancy: The Mommy Check-Up Study. Unknown status NCT02340624
10 Factors Influencing the Racial Disparity in Sudden Infant Death Syndrome (SIDS) Completed NCT01361893
11 Incidence and Severity of Cardiorespiratory Events in Infants at Increased Epidemiological Risk for Sudden Infant Death Syndrome (SIDS) Completed NCT00004392
12 Parental Knowledge and Beliefs About Infant Sleep Position Completed NCT00005567
13 Comparing Children's Book to Brochures for Safe Sleep Education in a Home Visiting Program Completed NCT02376673
14 Study of the Impact of Parental Note Taking on the Effectiveness of Anticipatory Guidance Completed NCT01014169
15 Magnetic Resonance Imaging Autopsy Study Completed NCT01417962
16 Reduce African-American Infant Mortality Completed NCT01361880
17 Impact of Smoke-free Legislation on Early-life Mortality and Low Birth Weight in England Completed NCT02039583
18 Characterization of Sweat Gland Function in Patients With Recessively Inherited Hypohidrotic Ectodermal Dysplasia Completed NCT01109290
19 Reducing Environmental Tobacco Smoke in Neonatal Intensive Care Unit (NICU) Infants' Homes Completed NCT00670280
20 Secondhand Smoke Exposure Reduction Among Young Children in China Completed NCT00995254
21 "Anticipatory Guidance in the Nursery and Its Impact on Non-urgent Emergency Department Visits" Completed NCT01859065
22 Re-enforcing Safe Sleep Practices for Caregivers With Tangible Incentives Completed NCT02010450
23 Assessing the Impact of Smoke-free Legislation on Perinatal Health in the Netherlands Completed NCT02189265
24 Varenicline Pregnancy Cohort Study Completed NCT01290445
25 Training Mothers of Infants in Infant Cardiopulmonary Resuscitation (CPR) Completed NCT00570869
26 Study of the Effect of Four Methods of Cardiopulmonary Resuscitation Instruction on Psychosocial Response of Parents With Infants at Risk of Sudden Death Completed NCT00004805
27 Cardiac Autonomic Control in Children of HIV Positive Mothers Completed NCT00005353
28 Enhancing Safe Sleep Practices of Urban Low-Income Mothers Recruiting NCT03070639
29 The Paediatric Virtual Autopsy Trial Recruiting NCT01888380
30 Brainstem and Prematurity Recruiting NCT02669056
31 Baby Nutrition and Physical Activity Self-Assessment for Child Care (NAP SACC) Intervention Study Recruiting NCT01890681
32 Is Gastroesophageal Reflux Really a Potential Risk for the Late Complications of Bronchopulmonary Dysplasia in Extremely Premature Infants? Recruiting NCT03014453
33 Effect of Antenatal SSRI Exposure on the QT Interval of Neonates Recruiting NCT02492347
34 Effects of Mother Position in Skin-to-skin Contact Newborn on Oxygen Saturation Levels. Recruiting NCT02585492
35 Pilot Study of Novel Postpartum Educational Video Intervention Active, not recruiting NCT02267265
36 Diagnostic Performance Comparison Between Procalcitonin-based vs. ANAES-based Guidelines Not yet recruiting NCT02590198
37 Changes in Sleep Patterns and Stress in Infants Entering Child Care Suspended NCT01265277

Search NIH Clinical Center for Sudden Infant Death Syndrome

Cochrane evidence based reviews: sudden infant death

Genetic Tests for Sudden Infant Death Syndrome

Genetic tests related to Sudden Infant Death Syndrome:

id Genetic test Affiliating Genes
1 Sudden Infant Death Syndrome 29

Anatomical Context for Sudden Infant Death Syndrome

MalaCards organs/tissues related to Sudden Infant Death Syndrome:

39
Brain, Heart, Lung, Breast, Testes, Liver, Hypothalamus

Publications for Sudden Infant Death Syndrome

Articles related to Sudden Infant Death Syndrome:

(show top 50) (show all 659)
id Title Authors Year
1
Sudden infant death syndrome due to long QT syndrome: a brief review of the genetic substrate and prevalence. ( 28316956 )
2017
2
Paediatricians' Practice About SUDDEN Infant Death Syndrome in Catalonia, Spain. ( 28160232 )
2017
3
Post-mortem whole-exome analysis in a large sudden infant death syndrome cohort with a focus on cardiovascular and metabolic genetic diseases. ( 28074886 )
2017
4
The gene encoding the inwardly rectifying potassium channel Kir4.1 may be involved in sudden infant death syndrome. ( 28520217 )
2017
5
Low cerebrospinal fluid hypocretin levels during sudden infant death syndrome (SIDS) risk period. ( 28449906 )
2017
6
Reducing the Risk of Sudden Infant Death Syndrome. ( 28166332 )
2017
7
Infant pacifiers for reduction in risk of sudden infant death syndrome. ( 28378502 )
2017
8
Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptor 1 (PAC1) in the human infant brain and changes in the Sudden Infant Death Syndrome (SIDS). ( 28392470 )
2017
9
Tricuspid Valve Hemangioma Associated with Hypoplastic Left Heart Syndrome Presenting as Sudden Infant Death Syndrome. ( 28272668 )
2017
10
A "Wear and Tear" Hypothesis to Explain Sudden Infant Death Syndrome. ( 27840622 )
2016
11
The Disappearance of Sudden Infant Death Syndrome. ( 27571448 )
2016
12
Area-based study shows most parents follow advice to reduce risk of sudden infant death syndrome. ( 27992061 )
2016
13
Candidate gene variants of the immune system and sudden infant death syndrome. ( 26975745 )
2016
14
Impaired orexin receptor expression in the KAPlliker-Fuse nucleus in sudden infant death syndrome: possible involvement of this nucleus in arousal pathophysiology. ( 27353953 )
2016
15
Synaptogenesis and Myelination in the Nucleus/Tractus Solitarius: Potential Role in Apnea of Prematurity, Congenital Central Hypoventilation, and Sudden Infant Death Syndrome. ( 26661483 )
2016
16
Environmental risk factors for sudden infant death syndrome in Japan. ( 27664161 )
2016
17
Sudden infant death syndrome caused by cardiac arrhythmias: only a matter of genes encoding ion channels? ( 26872470 )
2016
18
Maternal and obstetrical predictors of sudden infant death syndrome (SIDS). ( 27734747 )
2016
19
The Disappearance of Sudden Infant Death Syndrome: Has the Clock Turned Back? ( 26833064 )
2016
20
Nurses' Knowledge and Adherence To Sudden Infant Death Syndrome Prevention Guidelines. ( 27019936 )
2016
21
Proteomic MALDI-TOF/TOF-IMS examination of peptide expression in the formalin fixed brainstem and changes in sudden infant death syndrome infants. ( 26926438 )
2016
22
Aspiring to inspire - serotonin, the laryngeal chemoreflex and the sudden infant death syndrome. ( 27368108 )
2016
23
Hypothesis on supine sleep, sudden infant death syndrome reduction and association with increasing autism incidence. ( 27610351 )
2016
24
The Disappearance of Sudden Infant Death Syndrome-Reply. ( 27571548 )
2016
25
Risk Factors, Protective Factors, and Current Recommendations to Reduce Sudden Infant Death Syndrome: A Review. ( 27918760 )
2016
26
Sudden Infant Death Syndrome - Role of Trigeminocardiac Reflex: A Review. ( 27994573 )
2016
27
Promotion of the Unfolding Protein Response in Orexin/Dynorphin Neurons in Sudden Infant Death Syndrome (SIDS): Elevated pPERK and ATF4 Expression. ( 27796753 )
2016
28
Evolution and significance of the triple risk model in sudden infant death syndrome. ( 28028890 )
2016
29
Sudden infant death syndrome: exposure to cigarette smoke leads to hypomethylation upstream of the growth factor independent 1 (GFI1) gene promoter. ( 27677632 )
2016
30
Swaddling and the Risk of Sudden Infant Death Syndrome: A Meta-analysis. ( 27244847 )
2016
31
Sudden infant death syndrome: no significant expression of heat-shock proteins (HSP27, HSP70). ( 26662848 )
2016
32
Metabolomic profiling of brain from infants who died from Sudden Infant Death Syndrome reveals novel predictive biomarkers. ( 27608295 )
2016
33
Inner ear lesion and the differential roles of hypoxia and hypercarbia in triggering active movements: Potential implication for the Sudden Infant Death Syndrome. ( 27634772 )
2016
34
Medullary mediation of the laryngeal adductor reflex: A possible role in sudden infant death syndrome. ( 26774498 )
2016
35
Altered gene expression and possible immunodeficiency in cases of sudden infant death syndrome. ( 26959483 )
2016
36
Perinatal Fluoxetine Exposure Impairs the CO2 Chemoreflex: Implications for Sudden Infant Death Syndrome. ( 27018763 )
2016
37
Comment on Fard et al.'s Candidate gene variants of the immune system and sudden infant death syndrome. ( 27188625 )
2016
38
Incidence and determinants of sudden infant death syndrome: a population-based study on 37 million births. ( 25447630 )
2015
39
Association between sudden infant death syndrome and diphtheria-tetanus-pertussis immunisation: an ecological study. ( 25626628 )
2015
40
Variants in TSPYL1 are not associated with sudden infant death syndrome in a cohort of deceased infants from Switzerland. ( 25449952 )
2015
41
Escherichia coli and Sudden Infant Death Syndrome. ( 26191064 )
2015
42
Prenatal-perinatal Nicotine Alters Neonatal Raphe Neurons: Meaning for Sudden Infant Death Syndrome. ( 25695895 )
2015
43
Neonatal Nurses' Beliefs, Knowledge, and Practices in Relation to Sudden Infant Death Syndrome Risk-Reduction Recommendations. ( 25882389 )
2015
44
Sudden infant death syndrome and advice for safe sleeping. ( 25921604 )
2015
45
Polymorphisms in genes of respiratory control and sudden infant death syndrome. ( 26198620 )
2015
46
Sudden Infant Death Syndrome (SIDS). ( 26034863 )
2015
47
Undiagnosed metabolic dysfunction and sudden infant death syndrome--a case-control study. ( 25689231 )
2015
48
Decreased orexin (hypocretin) immunoreactivity in the hypothalamus and pontine nuclei in sudden infant death syndrome. ( 25953524 )
2015
49
Gut Microbiota and Immunity: Possible Role in Sudden Infant Death Syndrome. ( 26089821 )
2015
50
The role of the sodium current complex in a nonreferred nationwide cohort of sudden infant death syndrome. ( 25757662 )
2015

Variations for Sudden Infant Death Syndrome

UniProtKB/Swiss-Prot genetic disease variations for Sudden Infant Death Syndrome:

66 (show all 11)
id Symbol AA change Variation ID SNP ID
1 CAV3 p.Val14Leu VAR_043694 rs121909281
2 CAV3 p.Thr78Met VAR_043695 rs72546668
3 CAV3 p.Leu79Arg VAR_043696 rs121909282
4 GPD1L p.Glu83Lys VAR_044044 rs72552292
5 GPD1L p.Ile124Val VAR_044045 rs72552293
6 GPD1L p.Arg273Cys VAR_044046 rs72552294
7 KCNJ8 p.Val346Ile VAR_065879 rs147316959
8 SCN5A p.Ser1333Tyr VAR_036666 rs199473604
9 SCN5A p.Phe532Cys VAR_055177 rs199473573
10 SCN5A p.Gly1084Ser VAR_055185 rs199473190
11 SCN5A p.Phe1705Ser VAR_055207 rs199473627

ClinVar genetic disease variations for Sudden Infant Death Syndrome:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 MT-TL1 m.3290T> C single nucleotide variant Pathogenic rs199474665 GRCh37 Chromosome MT, 3290: 3290
2 MT-ND1 m.3308T> G single nucleotide variant Pathogenic rs28358582 GRCh37 Chromosome MT, 3308: 3308
3 KCNH2 NM_000238.3(KCNH2): c.2860C> T (p.Arg954Cys) single nucleotide variant Likely pathogenic rs141401803 GRCh37 Chromosome 7, 150644799: 150644799

Expression for Sudden Infant Death Syndrome

Search GEO for disease gene expression data for Sudden Infant Death Syndrome.

Pathways for Sudden Infant Death Syndrome

GO Terms for Sudden Infant Death Syndrome

Cellular components related to Sudden Infant Death Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 voltage-gated potassium channel complex GO:0008076 9.33 KCNH2 KCNJ8 KCNQ1
2 caveola GO:0005901 9.13 CAV3 HTR2A SCN5A
3 sarcolemma GO:0042383 8.92 CAV3 KCNJ8 SCN5A SNTA1

Biological processes related to Sudden Infant Death Syndrome according to GeneCards Suite gene sharing:

(show all 33)
id Name GO ID Score Top Affiliating Genes
1 regulation of ion transmembrane transport GO:0034765 9.86 KCNH2 KCNJ8 KCNQ1 SCN5A
2 cellular response to drug GO:0035690 9.77 KCNH2 KCNQ1 TH
3 memory GO:0007613 9.77 HTR2A SLC6A4 TH
4 social behavior GO:0035176 9.7 EN1 SLC6A4 TH
5 cardiac conduction GO:0061337 9.69 KCNH2 KCNQ1 SCN5A
6 regulation of sodium ion transmembrane transporter activity GO:2000649 9.66 CAV3 GPD1L
7 vasoconstriction GO:0042310 9.65 HTR1A SLC6A4
8 positive regulation of sodium ion transport GO:0010765 9.65 GPD1L SCN5A
9 positive regulation of potassium ion transmembrane transport GO:1901381 9.65 KCNH2 KCNQ1
10 cardiac muscle contraction GO:0060048 9.65 KCNH2 KCNQ1 SCN5A
11 regulation of membrane repolarization GO:0060306 9.64 KCNH2 KCNQ1
12 behavior GO:0007610 9.64 HTR1A HTR2A
13 negative regulation of potassium ion transport GO:0043267 9.63 ADCYAP1 HTR2A
14 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.63 KCNH2 KCNQ1
15 regulation of behavior GO:0050795 9.62 HTR1A HTR2A
16 atrial cardiac muscle cell action potential GO:0086014 9.62 KCNQ1 SCN5A
17 negative regulation of potassium ion transmembrane transport GO:1901380 9.61 CAV3 KCNH2
18 potassium ion export GO:0071435 9.61 KCNH2 KCNQ1
19 regulation of heart rate by cardiac conduction GO:0086091 9.61 KCNH2 KCNQ1 SCN5A
20 regulation of sodium ion transmembrane transport GO:1902305 9.58 SCN5A SNTA1
21 serotonin receptor signaling pathway GO:0007210 9.58 HTR1A HTR2A
22 regulation of heart contraction GO:0008016 9.58 CAV3 KCNQ1 TH
23 brainstem development GO:0003360 9.57 PHOX2B SCN5A
24 regulation of heart rate GO:0002027 9.56 CAV3 GPD1L SCN5A SNTA1
25 regulation of hormone secretion GO:0046883 9.55 HTR1A HTR2A
26 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.54 KCNQ1 SCN5A
27 neurotransmitter biosynthetic process GO:0042136 9.54 CHAT SLC6A4 TH
28 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.5 KCNH2 KCNJ8 KCNQ1
29 membrane repolarization during action potential GO:0086011 9.49 KCNH2 KCNQ1
30 potassium ion export across plasma membrane GO:0097623 9.46 KCNH2 KCNQ1
31 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.35 CAV3 KCNH2 KCNQ1 SCN5A SNTA1
32 regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 9.33 CAV3 GPD1L SCN5A
33 ventricular cardiac muscle cell action potential GO:0086005 9.1 CAV3 GPD1L KCNH2 KCNQ1 SCN5A SNTA1

Molecular functions related to Sudden Infant Death Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.88 ACADM GPD1L MAOA MT-ND1 TH
2 voltage-gated ion channel activity GO:0005244 9.62 KCNH2 KCNJ8 KCNQ1 SCN5A
3 ion channel binding GO:0044325 9.55 CAV3 GPD1L KCNQ1 SCN5A SNTA1
4 scaffold protein binding GO:0097110 9.54 KCNH2 KCNQ1 SCN5A
5 delayed rectifier potassium channel activity GO:0005251 9.46 KCNH2 KCNQ1
6 serotonin binding GO:0051378 9.43 HTR1A HTR2A
7 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 9.43 KCNH2 KCNJ8 KCNQ1
8 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 9.4 KCNH2 KCNQ1
9 sodium channel regulator activity GO:0017080 9.26 CAV3 GPD1L SCN5A SNTA1
10 nitric-oxide synthase binding GO:0050998 8.92 CAV3 SCN5A SLC6A4 SNTA1

Sources for Sudden Infant Death Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....