SIDS
MCID: SDD001
MIFTS: 65

Sudden Infant Death Syndrome (SIDS) malady

Summaries for Sudden Infant Death Syndrome

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:34 Sudden infant death syndrome (sids) is the sudden, unexplained death of an infant younger than one year old. some people call sids "crib death" because many babies who die of sids are found in their cribs. sids is the leading cause of death in children between one month and one year old. most sids deaths occur when babies are between two months and four months old. premature babies, boys, african americans, and american indian/alaska native infants have a higher risk of sids. although health care professionals don't know what causes sids, they do know ways to reduce the risk. these include placing babies on their backs to sleep, even for short naps. "tummy time" is for when babies are awake and someone is watching using a firm sleep surface, such as a crib mattress covered with a fitted sheet keeping soft objects and loose bedding away from sleep area making sure babies don't get too hot. keep the room at a comfortable temperature for an adult. nih: national institute of child health and human development

MalaCards: Sudden Infant Death Syndrome, also known as sudden infant death syndrome, susceptibility to, is related to medium-chain acyl-coenzyme a dehydrogenase deficiency and brugada syndrome. An important gene associated with Sudden Infant Death Syndrome is SCN5A (sodium channel, voltage-gated, type V, alpha subunit), and among its related pathways are Antiarrhythmic Pathway, Pharmacodynamics and Potassium Channels. The compounds verapamil and haloperidol have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and lung, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Disease Ontology:8 A syndrome that is characterized by the sudden death of an infant that is not predicted by medical history and remains unexplained after a thorough forensic autopsy and detailed death scene investigation.

CDC:3 Sudden unexpected infant deaths are defined as deaths in infants less than 1 year of age that occur suddenly and unexpectedly, and whose cause of death are not immediately obvious prior to investigation.

Wikipedia:64 Sudden infant death syndrome (SIDS) is marked by the sudden death of an infant that is not predicted by... more...

Description from OMIM:47 272120

Aliases & Classifications for Sudden Infant Death Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 9diseasecard, 22GTR, 57SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM
See all sources

Aliases & Descriptions:

sudden infant death syndrome 8 43 47 10 45 34 61
sudden infant death syndrome, susceptibility to 9 22
sids 8 43
sudden death of nonspecific cause in infancy 8
sudden infant death syndrome nos 8
crib death 8
cot death 8


External Ids:

Disease Ontology8 DOID:9007
OMIM47 272120
NCIt40 C85173
MeSH35 D013398
ICD9CM27 798.0

Related Diseases for Sudden Infant Death Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Sudden Infant Death Syndrome family:

sudden infant death with dysgenesis of the testes syndrome

Diseases related to Sudden Infant Death Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1medium-chain acyl-coenzyme a dehydrogenase deficiency30.5ACADM, ACADS
2brugada syndrome29.9GPD1L, SCN5A, KCNH2
3n syndrome11.1
4serotonin syndrome10.9
5hypoxia10.7
6char syndrome10.7
7bod syndrome10.6
8infant botulism10.5
9botulism10.5
10congenital central hypoventilation syndrome10.5
11central hypoventilation syndrome10.5
12hyperekplexia10.4
13german syndrome10.4
14sudden arrhythmia death syndrome10.4
15cav3-related sudden infant death syndrome10.4
16reye syndrome10.3
17hypophosphatemia10.3
18west syndrome10.3
19toxic shock syndrome10.3
20arc syndrome10.3
21micro syndrome10.3
22short syndrome10.3
23jervell-lange nielsen syndrome10.2
24desquamative interstitial pneumonia10.2
25hypohidrotic ectodermal dysplasia10.2
26prostate embryonal rhabdomyosarcoma10.2
27nasopharyngitis10.2
28fetal alcohol syndrome10.2
29adult syndrome10.2
30conn's syndrome10.2
31hypertrophic pyloric stenosis10.2
32asthma10.2
33infantile apnea10.2
34staphylococcal toxic shock syndrome10.2
35ectodermal dysplasia10.2
36infantile histiocytoid cardiomyopathy10.2
37kid syndrome10.2
38scot deficiency10.2
39mass syndrome10.2
40plagiocephaly10.2
41scott syndrome10.2
42autonomic dysfunction10.2
43cerebral hypoxia10.2
44megalencephaly10.2
45shaken baby syndrome10.2
46sleep apnea10.2
47orthostatic intolerance10.2
48audiogenic seizures10.2
49adrenocortical insufficiency10.2
50sudden cardiac death multi-gene panels10.0KCNH2, CAV3, SCN5A, ACADM, TSPYL1

Graphical network of the top 20 diseases related to Sudden Infant Death Syndrome:



Diseases related to sudden infant death syndrome

Clinical Features for Sudden Infant Death Syndrome

Sources:
47OMIM
See all sources

Clinical features from OMIM:

272120

Clinical synopsis from OMIM:

272120

Drugs & Therapeutics for Sudden Infant Death Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Sudden Infant Death Syndrome

Drug clinical trials:

Search ClinicalTrials for Sudden Infant Death Syndrome

Search NIH Clinical Center for Sudden Infant Death Syndrome

Search CenterWatch for Sudden Infant Death Syndrome

Genetic Tests for Sudden Infant Death Syndrome

Sources:
22GTR
See all sources

Genetic tests related to Sudden Infant Death Syndrome:

id Genetic test Affiliating Genes
1 Sudden Infant Death Syndrome22

Anatomical Context for Sudden Infant Death Syndrome

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Sudden Infant Death Syndrome:

33
Liver, Brain, Lung, Whole blood, Heart, Smooth muscle, Small intestine, Colon, Breast, Placenta, Prostate, B cells, Endothelial, Fetal brain, Hypothalamus, Medulla oblongata, Fetal liver, Fetal lung, Pituitary

Animal Models for Sudden Infant Death Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Sudden Infant Death Syndrome

Sources:
51PubMed
See all sources

Articles related to Sudden Infant Death Syndrome:

(show top 50)    (show all 572)
idTitleAuthorsYear
1
Head covering and SUDEP: lessons from sudden infant death syndrome. (23602225)
2013
2
Is there any correlation between HLA-DR expression in laryngeal mucosa and interleukin gene variation in sudden infant death syndrome? (23186119)
2013
3
Heat stress and sudden infant death syndrome--stress gene expression after exposure to moderate heat stress. (24053860)
2013
4
Is excess male infant mortality from sudden infant death syndrome and other respiratory diseases X-linked? (24164639)
2013
5
Hypophosphatemia as a key factor in sudden infant death syndrome (SIDS)? (23570456)
2013
6
Temporal trends in sudden infant death syndrome in Canada from 1991 to 2005: contribution of changes in cause of death assignment practices and in maternal and infant characteristics. (22324498)
2012
7
Rat homologues to the human post-neonatal period: models for vulnerability to the sudden infant death syndrome. (22162517)
2012
8
Serotonin in the sudden infant death syndrome. (21152449)
2010
9
Outcomes of heart transplantation using donor hearts from infants with sudden infant death syndrome. (20691612)
2010
10
Variant interleukin 1 receptor antagonist gene alleles in sudden infant death syndrome. (20880945)
2010
11
Cytokine gene polymorphisms and sudden infant death syndrome. (19958302)
2010
12
Immunohistochemical and molecular-pathological diagnosis of myocarditis in cases of suspected sudden infant death syndrome (SIDS)--a multicenter study. (19282217)
2009
13
Sudden infant death syndrome. (20050322)
2009
14
Socio-cultural perceptions of sudden infant death syndrome among migrant Indian mothers. (19845839)
2009
15
Role of congenital long-QT syndrome in unexplained sudden infant death: proposal for an electrocardiographic screening in relatives. (19266217)
2009
16
Risk factors for sudden infant death syndrome in a developing country. (18470361)
2008
17
Use of a fan during sleep and the risk of sudden infant death syndrome. (18838649)
2008
18
Serotonin transporter gene variation in sudden infant death syndrome. (18477062)
2008
19
An infectious aetiology of sudden infant death syndrome. (18266695)
2008
20
Overrepresentation of the proarrhythmic, sudden death predisposing sodium channel polymorphism S1103Y in a population-based cohort of African-American sudden infant death syndrome. (18452875)
2008
21
Hemoglobin F in sudden infant death syndrome: a San Diego SIDS/SUDC Research Project report. (17961870)
2007
22
Educating parents about the risk factors of sudden infant death syndrome: the role of neonatal intensive care unit and well baby nursery nurses. (17505237)
2007
23
Do risk factors differ between explained sudden unexpected death in infancy and sudden infant death syndrome? (16935913)
2007
24
Infant care practices associated with sudden infant death syndrome: findings from the Pacific Islands Families study. (17489830)
2007
25
Molecular and functional characterization of novel glycerol-3- phosphate dehydrogenase 1 like gene (GPD1-L) mutations in sudden infant death syndrome. (17967976)
2007
26
Risk of sudden infant death syndrome with parental mental illness. (17984401)
2007
27
Sudden infant death syndrome: another year of new hope but no cure. (17901755)
2007
28
Knowledge of sudden infant death syndrome prevention strategies in a multicultural, disadvantaged community. (16898882)
2006
29
Bed sharing with unimpaired parents is not an important risk for sudden infant death syndrome: to the editor. (16510693)
2006
30
Bed sharing with unimpaired parents is not an important risk for sudden infant death syndrome. (16510691)
2006
31
IL6 G-174C associated with sudden infant death syndrome in a Caucasian Australian cohort. (17055359)
2006
32
Use of a dummy (pacifier) during sleep and risk of sudden infant death syndrome (SIDS): population based case-control study. (16339767)
2006
33
Sudden infant death syndrome. (16135270)
2005
34
The changing concept of sudden infant death syndrome: diagnostic coding shifts, controversies regarding the sleeping environment, and new variables to consider in reducing risk. (16216901)
2005
35
Do pacifiers reduce the risk of sudden infant death syndrome? A meta-analysis. (16216900)
2005
36
Widening social inequalities in risk for sudden infant death syndrome. (16254231)
2005
37
Adult hemoglobin levels at birth and risk of sudden infant death syndrome. (15066877)
2004
38
Maternal smoking: an increasing unique risk factor for sudden infant death syndrome in Sweden. (15188973)
2004
39
Pathology research into sudden infant death syndrome: where do we go from here? (15286238)
2004
40
Sudden infant death syndrome due to parainfluenza virus 2 associated with hemophagocytic syndrome. (15474632)
2004
41
Analyses of the potential oxygen transfer capability in placentae from infants succumbing to sudden infant death syndrome. (14757264)
2004
42
Age at death, season, and day of death as indicators of the effect of the back to sleep program on sudden infant death syndrome in the United States, 1992-1999. (15066876)
2004
43
Interleukin 1-beta responses to bacterial toxins and sudden infant death syndrome. (15325407)
2004
44
Hazards in the epidemiological study of sudden infant death syndrome. (12716730)
2003
45
A comparison of the effects of parental risk markers on pre- and perinatal variables in multiple patient cohorts with fetal alcohol syndrome, autism, Tourette syndrome, and sudden infant death syndrome: an enviromic analysis. (14624970)
2003
46
Effect of a sudden infant death syndrome risk reduction education program on risk factor compliance and information sources in primarily black urban communities. (12671150)
2003
47
Intrauterine hypoxia and sudden infant death syndrome]. (12630342)
2002
48
Mannan binding lectin and the sudden infant death syndrome. (9871992)
1998
49
Hyperekplexia associated with apnea and sudden infant death syndrome. (8180653)
1994
50
Infant botulism: epidemiology and relation to sudden infant death syndrome. (7030764)
1981

Genetic Variations for Sudden Infant Death Syndrome

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Sudden Infant Death Syndrome:

63 (show all 11)
id Symbol AA change Variation SNP ID
1CAV3p.Val14LeuVAR_043694rs121909281
2CAV3p.Thr78MetVAR_043695rs72546668
3CAV3p.Leu79ArgVAR_043696
4GPD1Lp.Glu83LysVAR_044044
5GPD1Lp.Ile124ValVAR_044045rs72552293
6GPD1Lp.Arg273CysVAR_044046
7KCNJ8p.Val346IleVAR_065879
8SCN5Ap.Ser1333TyrVAR_036666
9SCN5Ap.Phe532CysVAR_055177
10SCN5Ap.Gly1084SerVAR_055185
11SCN5Ap.Phe1705SerVAR_055207

Expression for genes affiliated with Sudden Infant Death Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Sudden Infant Death Syndrome

Search GEO for disease gene expression data for Sudden Infant Death Syndrome.

Pathways for genes affiliated with Sudden Infant Death Syndrome

Sources:
50PharmGKB, 54Reactome, 30KEGG, 38NCBI BioSystems Database
See all sources

Pathways related to Sudden Infant Death Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5SCN5A, KCNH2, KCNJ8
2
Hide members
10.5SLC6A4, KCNH2, KCNJ8
3
Hide members
10.5ECHS1, ACADM
4
Hide members
10.5ACADS, ACADM, SLC25A20, TH, GPD1L
510.5ADCYAP1, KCNJ8, KCNH2, CAV3, SCN5A, PHOX2B
6
Hide members
10.5ACADS, ACADM, ECHS1
7
Hide members
10.5ECHS1, GPD1L, SLC25A20, ACADM, ACADS
8
Hide members
10.4ECHS1, SLC25A20, ACADM, ACADS

Compounds for genes affiliated with Sudden Infant Death Syndrome

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Sudden Infant Death Syndrome according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1verapamil45 50 29 11 2414.9KCNH2, SCN5A, TH, SLC6A4
2haloperidol45 29 2 50 1114.9KCNH2, TH, SLC6A4, ADCYAP1
3cocaine45 1111.9KCNH2, SCN5A, TH, SLC6A4
4arginine4510.9KCNH2, SCN5A, C4A, SLC25A20, SLC6A4, ACADM
5Octanoyl-Coenzyme A1110.9ACADM, ECHS1
6norepinephrine45 11 2412.9UCP1, PHOX2B, TH, SLC6A4, ADCYAP1
7cocaethylene4510.9KCNH2, SLC6A4
8carnitine4510.9ACADS, ACADM, SLC25A20, UCP1
9sodium45 2411.9KCNH2, CAV3, SCN5A, SNTA1, SLC6A4
10mazindol45 29 1112.9SLC6A4, TH
11fatty acid4510.9ADCYAP1, CAV3, UCP1, ECHS1, SLC25A20, ACADM
12Acetoacetyl-Coenzyme A1110.9ECHS1, ACADS
13flecainide45 50 29 1113.9SCN5A, KCNH2
14alanine4510.9KCNH2, UCP1, SCN5A, PHOX2B, TH, SLC6A4
15aspartate4510.9UCP1, SCN5A, TH, SLC6A4, ADCYAP1
16glutamate4510.9UCP1, TH, SLC6A4, ACADM, ACADS, ADCYAP1
17tetrodotoxin45 60 2912.9SCN5A, TH, ADCYAP1
18mexiletine45 1111.9KCNH2, SCN5A
19serine4510.9KCNH2, UCP1, SCN5A, C4A, C4B, SLC6A4
20propafenone45 50 29 1113.9KCNH2, SCN5A
21d amphetamine4510.9TH, SLC6A4
22cyclic amp45 2411.8KCNH2, UCP1, PHOX2B, TH, ADCYAP1
23mdma4510.8TH, SLC6A4
24Intravenous Immunoglobulin1110.8C4B, C4A
253-methylcrotonyl-coa45 2411.8ECHS1, ACADM
26oxygen45 2411.8KCNH2, UCP1, C4A, TH, ACADM, ADCYAP1
27acyl-coa4510.8SLC25A20, ACADM, ACADS
28(2E)-Tetradecenoyl-CoA2410.8ECHS1, ACADM, ACADS
29(2E)-Octenoyl-CoA2410.8ECHS1, ACADM, ACADS
30corticosterone45 60 2412.8ADCYAP1, SLC6A4, TH
31(2E)-Dodecenoyl-CoA2410.8ECHS1, ACADM, ACADS
32(2E)-Decenoyl-CoA2410.8ACADS, ACADM, ECHS1
33(2E)-Hexadecenoyl-CoA2410.7ACADS, ACADM, ECHS1
34testosterone45 60 11 2413.7KCNH2, UCP1, TH, SLC6A4, ADCYAP1
35catecholamine4510.7ADCYAP1, TH, UCP1
36trazodone45 29 1112.7KCNH2, SLC6A4
375-hydroxytryptophan4510.7SLC6A4, TH
38mhpg4510.7SLC6A4, TH
39methylphenidate45 50 1112.7SLC6A4, TH
40steroid4510.7KCNH2, IDS, C4A, C4B, ADCYAP1
41calcium45 50 11 2413.6KCNH2, CAV3, IDS, UCP1, SCN5A, C4B
42nimodipine45 29 1112.6TH, ADCYAP1
43maoa4510.5TH, SLC6A4
44potassium45 11 2412.5KCNJ8, KCNH2, SCN5A, ADCYAP1
45homovanillic acid45 2411.5SLC6A4, TH
46cisapride45 29 1112.4SCN5A, KCNH2
47bamhi4510.2ACADM, C4A

GO Terms for genes affiliated with Sudden Infant Death Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Sudden Infant Death Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrionGO:00573910.4UCP1, ECHS1, TH, SLC25A20, ACADM, ACADS
2sarcolemmaGO:04238310.2SNTA1, SCN5A, CAV3, KCNJ8

Biological processes related to Sudden Infant Death Syndrome according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of ventricular cardiac muscle cell action potentialGO:08600510.8GPD1L, SNTA1, SCN5A, CAV3, KCNH2
2regulation of ventricular cardiac muscle cell membrane repolarizationGO:06030710.8KCNH2, CAV3, SCN5A, SNTA1
3regulation of heart rateGO:00202710.8GPD1L, SNTA1, SCN5A, CAV3
4regulation of ventricular cardiac muscle cell membrane depolarizationGO:06037310.8CAV3, SCN5A, GPD1L
5cellular lipid metabolic processGO:04425510.7ACADS, ACADM, SLC25A20, GPD1L, ECHS1
6response to starvationGO:04259410.7ACADM, ACADS, ADCYAP1
7small molecule metabolic processGO:04428110.7IDS, UCP1, ECHS1, GPD1L, TH, SLC25A20
8fatty acid beta-oxidationGO:00663510.7ACADS, ACADM, ECHS1
9negative regulation of potassium ion transmembrane transportGO:190138010.7KCNH2, CAV3
10membrane depolarization involved in regulation of action potentialGO:08601010.6KCNH2, SCN5A
11regulation of sodium ion transmembrane transportGO:190230510.6SCN5A, SNTA1
12fatty acid beta-oxidation using acyl-CoA dehydrogenaseGO:03353910.5ACADM, ACADS
13brainstem developmentGO:00336010.5SCN5A, PHOX2B
14regulation of heart rate by cardiac conductionGO:08609110.5SCN5A, KCNH2
15regulation of sodium ion transmembrane transporter activityGO:200064910.4GPD1L, CAV3
16positive regulation of sodium ion transportGO:01076510.2GPD1L, SCN5A

Molecular functions related to Sudden Infant Death Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nitric-oxide synthase bindingGO:05099810.6SLC6A4, SNTA1, SCN5A, CAV3
2ion channel bindingGO:04432510.5CAV3, SCN5A, SNTA1, GPD1L
3inward rectifier potassium channel activityGO:00524210.5KCNH2, KCNJ8
4sodium channel regulator activityGO:01708010.4GPD1L, SNTA1, CAV3
5acyl-CoA dehydrogenase activityGO:00399510.2ACADS, ACADM

Products for genes affiliated with Sudden Infant Death Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sudden Infant Death Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet