SIDS
MCID: SDD001
MIFTS: 61

Sudden Infant Death Syndrome (SIDS) malady

Categories: Genetic diseases, Rare diseases

Aliases & Classifications for Sudden Infant Death Syndrome

About this section

Aliases & Descriptions for Sudden Infant Death Syndrome:

Name: Sudden Infant Death Syndrome 52 11 48 70 27 50 38 2 13 68
Sids 11 48 70 2
Sudden Infant Death Syndrome, Susceptibility to 12
Sudden Death of Nonspecific Cause in Infancy 11
 
Sudden Infant Death Syndrome Nos 11
Sudden Infant Death 39
Crib Death 11
Cot Death 11

Characteristics:

HPO:

64
sudden infant death syndrome:
Mortality/Aging: sudden death

Classifications:



External Ids:

OMIM52 272120
Disease Ontology11 DOID:9007
ICD9CM32 798.0
MeSH39 D013398
NCIt45 C85173
MedGen37 C0038644
ICD1030 R95

Summaries for Sudden Infant Death Syndrome

About this section
MedlinePlus:38 Sudden infant death syndrome (sids) is the sudden, unexplained death of an infant younger than one year old. some people call sids "crib death" because many babies who die of sids are found in their cribs. sids is the leading cause of death in children between one month and one year old. most sids deaths occur when babies are between one month and four months old. premature babies, boys, african americans, and american indian/alaska native infants have a higher risk of sids. although health care professionals don't know what causes sids, they do know ways to reduce the risk. these include placing your baby on his or her back to sleep, even for short naps. "tummy time" is for when babies are awake and someone is watching having your baby sleep in your room for at least the first six months. your baby should sleep close to you, but on a separate surface designed for infants, such as a crib or bassinet. using a firm sleep surface, such as a crib mattress covered with a fitted sheet keeping soft objects and loose bedding away from your baby's sleep area breastfeeding your baby making sure that your baby doesn't get too hot. keep the room at a comfortable temperature for an adult. not smoking during pregnancy or allowing anyone to smoke near your baby nih: national institute of child health and human development

MalaCards based summary: Sudden Infant Death Syndrome, also known as SIDS, is related to sudden infant death with dysgenesis of the testes syndrome and cav3-related sudden infant death syndrome, and has symptoms including apneic episodes in infancy An important gene associated with Sudden Infant Death Syndrome is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways are Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction) and Dopamine metabolism. Affiliated tissues include brain, heart and breast, and related mouse phenotypes are muscle and behavior/neurological.

Disease Ontology:11 A syndrome that is characterized by the sudden death of an infant that is not predicted by medical history and remains unexplained after a thorough forensic autopsy and detailed death scene investigation.

NIH Rare Diseases:48 Sudden infant death syndrome (sids) is the unexpected, sudden death of a child under age 1 which cannot be explained after a thorough investigation is conducted. infants who are affected by the condition generally appear healthy with no suspicious signs and symptoms prior to the incident. it is the leading cause of death in infants age 1 to 12 months old. the exact underlying cause of sids is unknown; however, scientists suspect that it is likely a multifactorial condition (associated with the effects of multiple genes in combination with lifestyle and environmental factors). although there is no guaranteed way to prevent sids, the american academy of pediatrics has a published list of recommendations for risk reduction. please click on the link to access this resource. last updated: 12/15/2015

OMIM:52 Sudden infant death syndrome (SIDS) is a diagnosis of exclusion which should be made only after a thorough autopsy... (272120) more...

UniProtKB/Swiss-Prot:70 Sudden infant death syndrome: SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive.

Wikipedia:71 Sudden infant death syndrome (SIDS), also known as cot death or crib death, is the sudden unexplained... more...

Related Diseases for Sudden Infant Death Syndrome

About this section

Diseases in the Sudden Infant Death Syndrome family:

Cav3-Related Sudden Infant Death Syndrome

Diseases related to Sudden Infant Death Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1sudden infant death with dysgenesis of the testes syndrome12.7
2cav3-related sudden infant death syndrome12.2
3hyperekplexia11.3
4reye syndrome11.2
5infantile apnea11.2
6infantile histiocytoid cardiomyopathy11.0
7lipodystrophy, familial partial, type 510.4CAV3, SCN5A, SNTA1
8migraine with aura 910.4KCNH2, KCNQ1, SCN5A
9brugada syndrome 110.4KCNH2, KCNQ1, SCN5A
10familial sick sinus syndrome10.4KCNH2, KCNQ1, SCN5A
11isolated encephalocele10.4KCNH2, KCNQ1, SCN5A
12keppen-lubinsky syndrome10.4KCNH2, KCNQ1, SCN5A
13parkinson disease 20, early-onset10.4KCNH2, KCNQ1, SCN5A
14developmental dysplasia of the hip 210.4GPD1L, SCN5A
15adult brainstem astrocytoma10.4HTR1A, MAOA, SLC6A4
16renpenning syndrome10.4HTR1A, MAOA, SLC6A4
17specific language impairment 410.4CAV3, KCNH2, KCNQ1, SCN5A
18multicentric carpotarsal osteolysis syndrome10.4KCNH2, KCNQ1, SCN5A, SNTA1
19short qt syndrome 210.4CAV3, KCNH2, KCNQ1, SCN5A
20kidney pelvis papillary carcinoma10.4HTR1A, MAOA, SLC6A4
21sick sinus syndrome 110.4KCNH2, KCNQ1, SCN5A
22neurogenic bladder10.4HTR2A, MAOA, SLC6A4
23dry eye syndrome10.4HTR1A, HTR2A, SLC6A4
24tinea pedis10.4HTR1A, MAOA, SLC6A4
25pyromania10.4HTR2A, MAOA, SLC6A4
26tardbp-related frontotemporal dementia10.4KCNH2, KCNQ1, SCN5A
27chronic eosinophilic pneumonia10.4HTR1A, MAOA, SLC6A4
28waardenburg's syndrome10.4HTR1A, HTR2A, SLC6A4
29hypoglycemic coma10.4HTR1A, HTR2A, MAOA, SLC6A4
30cytomegalic congenital adrenal hypoplasia10.4HTR2A, MAOA, SLC6A4, TH
31multiple personality disorder10.4HTR1A, HTR2A, MAOA, SLC6A4
32intrahepatic gall duct cancer10.4HTR2A, MAOA, SLC6A4
33atrial fibrillation, familial, 310.4CAV3, KCNH2, KCNQ1, SCN5A, SNTA1
34hepatitis b reinfection following liver transplantation10.4HTR1A, HTR2A, MAOA, SLC6A4
35postencephalitic parkinson disease10.4HTR1A, HTR2A, MAOA, SLC6A4
36hyperthyroxinemia10.4CAV3, KCNH2, KCNQ1, SCN5A, SNTA1
37third-degree atrioventricular block10.4KCNH2, KCNQ1, SCN5A
38keratosis10.4HTR1A, HTR2A, MAOA, SLC6A4
39cecal benign neoplasm10.4HTR1A, HTR2A, MAOA, SLC6A4
40familial periodic paralysis10.4KCNH2, KCNQ1, SCN5A
41lichen disease10.3HTR1A, HTR2A, MAOA, SLC6A4
42fechtner syndrome10.3HTR1A, HTR2A, MAOA, SLC6A4
43hereditary multiple exostoses10.3ADCYAP1, HTR2A, MAOA, SLC6A4
44hepatitis d10.3HTR1A, HTR2A, MAOA, SLC6A4
45primary angle-closure glaucoma10.3HTR1A, HTR2A, SLC6A4
46antley-bixler syndrome10.3CAV3, GPD1L, KCNH2, KCNJ8, KCNQ1, SCN5A
47retinoblastoma10.3HTR1A, HTR2A, MAOA, SLC6A4
48autosomal dominant nocturnal frontal lobe epilepsy 210.3KCNH2, KCNQ1, SCN5A
49polyneuropathy10.3HTR1A, HTR2A
50personality disorder10.3HTR1A, HTR2A, MAOA, SLC6A4

Graphical network of the top 20 diseases related to Sudden Infant Death Syndrome:



Diseases related to sudden infant death syndrome

Symptoms & Phenotypes for Sudden Infant Death Syndrome

About this section

Symptoms by clinical synopsis from OMIM:

272120

Clinical features from OMIM:

272120

Human phenotypes related to Sudden Infant Death Syndrome:

 64
id Description HPO Frequency HPO Source Accession
1 apneic episodes in infancy64 HP:0005949

MGI Mouse Phenotypes related to Sudden Infant Death Syndrome according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.1ACADM, ADCYAP1, CAV3, CHAT, EN1, HTR2A
2MP:00053869.9ADCYAP1, CHAT, EN1, HTR1A, HTR2A, KCNQ1
3MP:00053859.9ACADM, CAV3, CHAT, EN1, HTR1A, KCNH2
4MP:00053769.7ACADM, ADCYAP1, CAV3, CHAT, EN1, HTR1A
5MP:00036319.2ADCYAP1, CHAT, EN1, HTR1A, KCNQ1, MAOA

Drugs & Therapeutics for Sudden Infant Death Syndrome

About this section

Drugs for Sudden Infant Death Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
NicotineapprovedPhase 4, Phase 2110354-11-5942, 89594
Synonyms:
(−
(+)-Nicotine
(-)-3-(1-Methyl-2-pyrrolidyl)pyridine
(-)-3-(N-Methylpyrrolidino)pyridine
(-)-Nicotine
(-)-Nicotine solution
(2S) 3-(1-Methyl-pyrrolidin-2-yl)-pyridine
(R)-3-(1-Methyl-2-pyrrolidinyl)pyridine
(R,S)-Nicotine
(S)-(-)-NICOTINE, 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE
(S)-(-)-Nicotine
(S)-(−)-nicotine
(S)-3-(1-methylpyrrolidin-2-yl)pyridine
(S)-3-(N-methylpyrrolidin-2-yl)pyridine
(S)-Nicotine
(−)-nicotine
)-1-Methyl-2-(3-pyridyl)pyrrolidine
)-Nicotine
)-Nicotine solution
1-Methyl-2-(3-pyridal)-Pyrrolidine
1-Methyl-2-(3-pyridal)-pyrrolidene
1-Methyl-2-(3-pyridiyl)pyrrolidine
1-Methyl-2-(3-pyridyl)pyrrolidine
1uw6
2'-beta-H-Nicotine
3-(1-Methyl-2-pyrollidinyl)pyridine
3-(1-Methyl-2-pyrrolidinyl)-Pyridine
3-(1-Methyl-2-pyrrolidinyl)pyridine
3-(1-Methylpyrrolidin-2-yl)pyridine
3-(2-(N-methylpyrrolidinyl))pyridine
3-(N-Methylpyrollidino)pyridine
3-(N-Methylpyrrolidino)pyridine
3-(N-methylpyrollidino)pyridine
3-N-Methylpyrrolidine
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
36733_FLUKA
36733_RIEDEL
434F7990-3240-4A43-ACEC-E6CC1E495FA0
46343_FLUKA
46343_RIEDEL
54-11-5
AC1L3I79
AC1Q3ZOC
AI3-03424
BB_NC-0777
BIDD:GT0599
BRD-K05395900-322-02-1
Black Leaf
Black Leaf 40
C00745
CCRIS 1637
CHEBI:17688
CHEMBL3
CID89594
CPD000059074
Campbell's Nico-Soap
Caswell No. 597
Commit
D-Nicotine
D03365
DL-tetrahydronicotyrine
Destruxol
Destruxol Orchid Spray
EINECS 200-193-3
ENT 3,424
EPA Pesticide Chemical Code 056702
Emo-Nik
Flux Maag
Fumeto bac
Fumetobac
HSDB 1107
Habitrol
Habitrol (TN)
L(-)-nicotine
L(−)-nicotine
L-3-(1-Methyl-2-pyrrolidyl)pyridine
 
L-Nicotine
LS-202
MLS001055457
MLS001335905
Mach-Nic
Methyl-2-pyrrolidinyl)pyridine
Micotine
MolPort-000-744-731
N3876_SIGMA
N5511_FLUKA
N5511_SIGMA
NCGC00090693-01
NCGC00090693-02
NCGC00090693-03
NCGC00090693-04
NCGC00090693-05
NCGC00090693-06
NCGC00090693-07
NCT
NICOTINE AND SALTS
NSC 5065
NSC97238
Niagara P.A. Dust
Nic-Sal
Nico-Dust
Nico-Fume
Nicocide
Nicoderm
Nicoderm Cq
Nicoderm Patch
Nicorette
Nicorette Plus
Nicotin
Nicotina
Nicotina [Italian]
Nicotine
Nicotine (USP)
Nicotine (compounds related to)
Nicotine Alkaloid
Nicotine Patch
Nicotine Polacrilex
Nicotine [BSI:ISO]
Nicotine [UN1654]
Nicotine [UN1654] [Poison]
Nicotine [USAN]
Nicotrol
Nicotrol Inhaler
Nicotrol Ns
Nictoine patch
Nikotin
Nikotin [German]
Nikotyna
Nikotyna [Polish]
Ortho N-4 Dust
Ortho N-5 Dust
PDSP1_000113
PDSP1_000465
PDSP2_000463
PDSP2_000555
Prostep
R)-(+)-Nicotine
RCRA waste no. P075
RCRA waste number P075
SAM002564224
SDCCGMLS-0066911.P001
SMR000059074
Tendust
Transdermal Nicotine
UN1654
a -N-Methylpyrrolidine
a-N-Methylpyrrolidine
alpha-N-Methylpyrrolidine
beta-Pyridyl-alpha-N-methyl pyrrolidine
beta-Pyridyl-alpha-N-methylpyrrolidine
bmse000105
delta-Nicotine
nicotine
nicotine replacement patch
2Peripheral Nervous System AgentsPhase 2, Phase 3, Phase 123689
3Neurotransmitter AgentsPhase 2, Phase 3, Phase 118340
4Autonomic AgentsPhase 2, Phase 3, Phase 110150
5Cholinergic AgentsPhase 23992
6Nicotinic AgonistsPhase 2945
7Central Nervous System StimulantsPhase 22211
8
Vareniclineapproved, investigational273249296-44-45310966
Synonyms:
249296-44-4
7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine
7,8,9,10-tetrahydro-6h-6,10-methanoazepino[4,5-g]quinoxaline
AC1L55H0
AC1Q4W6H
AKOS005145561
AR-1H2911
CHEBI:430452
CHEMBL1396
CID170361
CP 526555
 
CP-526,555
Champix
Chantix
D08669
HSDB 7591
I14-1963
LS-187375
UNII-W6HS99O8ZO
Varenicline
Varenicline (INN)
Varenicline tartrate
varenicline
9Serotonin Agents3156
10Serotonin Uptake Inhibitors1587
11Neurotransmitter Uptake Inhibitors3521
12Anti-Bacterial Agents11226
13
Serotonin362750-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
14Antibiotics, Antitubercular7180

Interventional clinical trials:

(show all 37)
idNameStatusNCT IDPhase
1PRIDE: Preventing Respiratory Illnesses During Childhood StudyCompletedNCT00927264Phase 4
2Influence of Pacifiers on Breastfeeding DurationCompletedNCT00306956Phase 3
3Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia TrialWithdrawnNCT00293735Phase 2, Phase 3
4Effectiveness of Nicotine Replacement Therapy in Reducing the Risk of Nicotine Exposure in Pregnant Minority SmokersCompletedNCT00341432Phase 2
5Treatment Targets for Chronic Hypertension in PregnancyWithdrawnNCT00194974Phase 1, Phase 2
6Is Home Positioning Time Associated With Torticollis Rate of Recovery?CompletedNCT00347334Phase 1
7Do Pacifiers Protect From Sudden Infant Death Syndrome (SIDS) Through an Increase in Upper Airway Patency?Unknown statusNCT01120938
8Validation of a Non Invasive Blood Marker of SIDS and Vagal DisordersUnknown statusNCT01358461
9Optimizing Technology-Delivered Interventions for Smoking in Pregnancy: The Mommy Check-Up Study.Unknown statusNCT02340624
10Factors Influencing the Racial Disparity in Sudden Infant Death Syndrome (SIDS)CompletedNCT01361893
11Incidence and Severity of Cardiorespiratory Events in Infants at Increased Epidemiological Risk for Sudden Infant Death Syndrome (SIDS)CompletedNCT00004392
12Parental Knowledge and Beliefs About Infant Sleep PositionCompletedNCT00005567
13Comparing Children's Book to Brochures for Safe Sleep Education in a Home Visiting ProgramCompletedNCT02376673
14Study of the Impact of Parental Note Taking on the Effectiveness of Anticipatory GuidanceCompletedNCT01014169
15Magnetic Resonance Imaging Autopsy StudyCompletedNCT01417962
16Reduce African-American Infant MortalityCompletedNCT01361880
17Impact of Smoke-free Legislation on Early-life Mortality and Low Birth Weight in EnglandCompletedNCT02039583
18Characterization of Sweat Gland Function in Patients With Recessively Inherited Hypohidrotic Ectodermal DysplasiaCompletedNCT01109290
19Reducing Environmental Tobacco Smoke in Neonatal Intensive Care Unit (NICU) Infants' HomesCompletedNCT00670280
20Secondhand Smoke Exposure Reduction Among Young Children in ChinaCompletedNCT00995254
21"Anticipatory Guidance in the Nursery and Its Impact on Non-urgent Emergency Department Visits"CompletedNCT01859065
22Re-enforcing Safe Sleep Practices for Caregivers With Tangible IncentivesCompletedNCT02010450
23Assessing the Impact of Smoke-free Legislation on Perinatal Health in the NetherlandsCompletedNCT02189265
24Varenicline Pregnancy Cohort StudyCompletedNCT01290445
25Training Mothers of Infants in Infant Cardiopulmonary Resuscitation (CPR)CompletedNCT00570869
26Study of the Effect of Four Methods of Cardiopulmonary Resuscitation Instruction on Psychosocial Response of Parents With Infants at Risk of Sudden DeathCompletedNCT00004805
27Cardiac Autonomic Control in Children of HIV Positive MothersCompletedNCT00005353
28Enhancing Safe Sleep Practices of Urban Low-Income MothersRecruitingNCT03070639
29The Paediatric Virtual Autopsy TrialRecruitingNCT01888380
30Brainstem and PrematurityRecruitingNCT02669056
31Baby Nutrition and Physical Activity Self-Assessment for Child Care (NAP SACC) Intervention StudyRecruitingNCT01890681
32Is Gastroesophageal Reflux Really a Potential Risk for the Late Complications of Bronchopulmonary Dysplasia in Extremely Premature Infants?RecruitingNCT03014453
33Effect of Antenatal SSRI Exposure on the QT Interval of NeonatesRecruitingNCT02492347
34Effects of Mother Position in Skin-to-skin Contact Newborn on Oxygen Saturation Levels.RecruitingNCT02585492
35Pilot Study of Novel Postpartum Educational Video InterventionActive, not recruitingNCT02267265
36Diagnostic Performance Comparison Between Procalcitonin-based vs. ANAES-based GuidelinesNot yet recruitingNCT02590198
37Changes in Sleep Patterns and Stress in Infants Entering Child CareSuspendedNCT01265277

Search NIH Clinical Center for Sudden Infant Death Syndrome


Cochrane evidence based reviews: sudden infant death

Genetic Tests for Sudden Infant Death Syndrome

About this section

Genetic tests related to Sudden Infant Death Syndrome:

id Genetic test Affiliating Genes
1 Sudden Infant Death Syndrome27

Anatomical Context for Sudden Infant Death Syndrome

About this section

MalaCards organs/tissues related to Sudden Infant Death Syndrome:

36
Brain, Heart, Breast, Lung, Hypothalamus, Testes, Liver

Publications for Sudden Infant Death Syndrome

About this section

Articles related to Sudden Infant Death Syndrome:

(show top 50)    (show all 659)
idTitleAuthorsYear
1
Sudden infant death syndrome due to long QT syndrome: a brief review of the genetic substrate and prevalence. (28316956)
2017
2
Paediatricians' Practice About SUDDEN Infant Death Syndrome in Catalonia, Spain. (28160232)
2017
3
Post-mortem whole-exome analysis in a large sudden infant death syndrome cohort with a focus on cardiovascular and metabolic genetic diseases. (28074886)
2017
4
The gene encoding the inwardly rectifying potassium channel Kir4.1 may be involved in sudden infant death syndrome. (28520217)
2017
5
Low cerebrospinal fluid hypocretin levels during sudden infant death syndrome (SIDS) risk period. (28449906)
2017
6
Reducing the Risk of Sudden Infant Death Syndrome. (28166332)
2017
7
Infant pacifiers for reduction in risk of sudden infant death syndrome. (28378502)
2017
8
Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptor 1 (PAC1) in the human infant brain and changes in the Sudden Infant Death Syndrome (SIDS). (28392470)
2017
9
Tricuspid Valve Hemangioma Associated with Hypoplastic Left Heart Syndrome Presenting as Sudden Infant Death Syndrome. (28272668)
2017
10
A "Wear and Tear" Hypothesis to Explain Sudden Infant Death Syndrome. (27840622)
2016
11
The Disappearance of Sudden Infant Death Syndrome. (27571448)
2016
12
Area-based study shows most parents follow advice to reduce risk of sudden infant death syndrome. (27992061)
2016
13
Candidate gene variants of the immune system and sudden infant death syndrome. (26975745)
2016
14
Impaired orexin receptor expression in the KAPlliker-Fuse nucleus in sudden infant death syndrome: possible involvement of this nucleus in arousal pathophysiology. (27353953)
2016
15
Synaptogenesis and Myelination in the Nucleus/Tractus Solitarius: Potential Role in Apnea of Prematurity, Congenital Central Hypoventilation, and Sudden Infant Death Syndrome. (26661483)
2016
16
Environmental risk factors for sudden infant death syndrome in Japan. (27664161)
2016
17
Sudden infant death syndrome caused by cardiac arrhythmias: only a matter of genes encoding ion channels? (26872470)
2016
18
Maternal and obstetrical predictors of sudden infant death syndrome (SIDS). (27734747)
2016
19
The Disappearance of Sudden Infant Death Syndrome: Has the Clock Turned Back? (26833064)
2016
20
Nurses' Knowledge and Adherence To Sudden Infant Death Syndrome Prevention Guidelines. (27019936)
2016
21
Proteomic MALDI-TOF/TOF-IMS examination of peptide expression in the formalin fixed brainstem and changes in sudden infant death syndrome infants. (26926438)
2016
22
Aspiring to inspire - serotonin, the laryngeal chemoreflex and the sudden infant death syndrome. (27368108)
2016
23
Hypothesis on supine sleep, sudden infant death syndrome reduction and association with increasing autism incidence. (27610351)
2016
24
The Disappearance of Sudden Infant Death Syndrome-Reply. (27571548)
2016
25
Risk Factors, Protective Factors, and Current Recommendations to Reduce Sudden Infant Death Syndrome: A Review. (27918760)
2016
26
Sudden Infant Death Syndrome - Role of Trigeminocardiac Reflex: A Review. (27994573)
2016
27
Promotion of the Unfolding Protein Response in Orexin/Dynorphin Neurons in Sudden Infant Death Syndrome (SIDS): Elevated pPERK and ATF4 Expression. (27796753)
2016
28
Evolution and significance of the triple risk model in sudden infant death syndrome. (28028890)
2016
29
Sudden infant death syndrome: exposure to cigarette smoke leads to hypomethylation upstream of the growth factor independent 1 (GFI1) gene promoter. (27677632)
2016
30
Swaddling and the Risk of Sudden Infant Death Syndrome: A Meta-analysis. (27244847)
2016
31
Sudden infant death syndrome: no significant expression of heat-shock proteins (HSP27, HSP70). (26662848)
2016
32
Metabolomic profiling of brain from infants who died from Sudden Infant Death Syndrome reveals novel predictive biomarkers. (27608295)
2016
33
Inner ear lesion and the differential roles of hypoxia and hypercarbia in triggering active movements: Potential implication for the Sudden Infant Death Syndrome. (27634772)
2016
34
Medullary mediation of the laryngeal adductor reflex: A possible role in sudden infant death syndrome. (26774498)
2016
35
Altered gene expression and possible immunodeficiency in cases of sudden infant death syndrome. (26959483)
2016
36
Perinatal Fluoxetine Exposure Impairs the CO2 Chemoreflex: Implications for Sudden Infant Death Syndrome. (27018763)
2016
37
Comment on Fard et al.'s Candidate gene variants of the immune system and sudden infant death syndrome. (27188625)
2016
38
Incidence and determinants of sudden infant death syndrome: a population-based study on 37 million births. (25447630)
2015
39
Association between sudden infant death syndrome and diphtheria-tetanus-pertussis immunisation: an ecological study. (25626628)
2015
40
Variants in TSPYL1 are not associated with sudden infant death syndrome in a cohort of deceased infants from Switzerland. (25449952)
2015
41
Escherichia coli and Sudden Infant Death Syndrome. (26191064)
2015
42
Prenatal-perinatal Nicotine Alters Neonatal Raphe Neurons: Meaning for Sudden Infant Death Syndrome. (25695895)
2015
43
Neonatal Nurses' Beliefs, Knowledge, and Practices in Relation to Sudden Infant Death Syndrome Risk-Reduction Recommendations. (25882389)
2015
44
Sudden infant death syndrome and advice for safe sleeping. (25921604)
2015
45
Polymorphisms in genes of respiratory control and sudden infant death syndrome. (26198620)
2015
46
Sudden Infant Death Syndrome (SIDS). (26034863)
2015
47
Undiagnosed metabolic dysfunction and sudden infant death syndrome--a case-control study. (25689231)
2015
48
Decreased orexin (hypocretin) immunoreactivity in the hypothalamus and pontine nuclei in sudden infant death syndrome. (25953524)
2015
49
Gut Microbiota and Immunity: Possible Role in Sudden Infant Death Syndrome. (26089821)
2015
50
The role of the sodium current complex in a nonreferred nationwide cohort of sudden infant death syndrome. (25757662)
2015

Variations for Sudden Infant Death Syndrome

About this section

UniProtKB/Swiss-Prot genetic disease variations for Sudden Infant Death Syndrome:

70 (show all 11)
id Symbol AA change Variation ID SNP ID
1CAV3p.Val14LeuVAR_043694rs121909281
2CAV3p.Thr78MetVAR_043695rs72546668
3CAV3p.Leu79ArgVAR_043696rs121909282
4GPD1Lp.Glu83LysVAR_044044rs72552292
5GPD1Lp.Ile124ValVAR_044045rs72552293
6GPD1Lp.Arg273CysVAR_044046rs72552294
7KCNJ8p.Val346IleVAR_065879rs147316959
8SCN5Ap.Ser1333TyrVAR_036666rs199473604
9SCN5Ap.Phe532CysVAR_055177rs199473573
10SCN5Ap.Gly1084SerVAR_055185rs199473190
11SCN5Ap.Phe1705SerVAR_055207rs199473627

Clinvar genetic disease variations for Sudden Infant Death Syndrome:

5
id Gene Variation Type Significance SNP ID Assembly Location
1KCNH2NM_ 000238.3(KCNH2): c.2860C> T (p.Arg954Cys)SNVLikely pathogenicrs141401803GRCh37Chr 7, 150644799: 150644799
2MT-TL1m.3290T> CSNVPathogenicrs199474665GRCh37Chr MT, 3290: 3290
3MT-ND1m.3308T> GSNVPathogenicrs28358582GRCh37Chr MT, 3308: 3308

Expression for genes affiliated with Sudden Infant Death Syndrome

About this section
Search GEO for disease gene expression data for Sudden Infant Death Syndrome.

Pathways for genes affiliated with Sudden Infant Death Syndrome

About this section

GO Terms for genes affiliated with Sudden Infant Death Syndrome

About this section

Cellular components related to Sudden Infant Death Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1caveolaGO:000590110.8CAV3, HTR2A, SCN5A
2sarcolemmaGO:004238310.6CAV3, KCNJ8, SCN5A, SNTA1
3voltage-gated potassium channel complexGO:000807610.1KCNH2, KCNJ8, KCNQ1

Biological processes related to Sudden Infant Death Syndrome according to GeneCards Suite gene sharing:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1brainstem developmentGO:000336011.0PHOX2B, SCN5A
2positive regulation of sodium ion transportGO:001076511.0GPD1L, SCN5A
3atrial cardiac muscle cell action potentialGO:008601410.9KCNQ1, SCN5A
4negative regulation of potassium ion transmembrane transportGO:190138010.9CAV3, KCNH2
5regulation of atrial cardiac muscle cell membrane repolarizationGO:006037210.9KCNQ1, SCN5A
6membrane repolarization during action potentialGO:008601110.9KCNH2, KCNQ1
7membrane repolarization during cardiac muscle cell action potentialGO:008601310.9KCNH2, KCNQ1
8behaviorGO:000761010.9HTR1A, HTR2A
9negative regulation of potassium ion transportGO:004326710.9ADCYAP1, HTR2A
10positive regulation of potassium ion transmembrane transportGO:190138110.9KCNH2, KCNQ1
11potassium ion exportGO:007143510.9KCNH2, KCNQ1
12potassium ion export across plasma membraneGO:009762310.9KCNH2, KCNQ1
13regulation of behaviorGO:005079510.9HTR1A, HTR2A
14regulation of sodium ion transmembrane transportGO:190230510.9SCN5A, SNTA1
15regulation of hormone secretionGO:004688310.8HTR1A, HTR2A
16cardiac conductionGO:006133710.8KCNH2, KCNQ1, SCN5A
17regulation of sodium ion transmembrane transporter activityGO:200064910.8CAV3, GPD1L
18cardiac muscle contractionGO:006004810.8KCNH2, KCNQ1, SCN5A
19membrane repolarization during ventricular cardiac muscle cell action potentialGO:009891510.8KCNH2, KCNJ8, KCNQ1
20memoryGO:000761310.8HTR2A, SLC6A4, TH
21neurotransmitter biosynthetic processGO:004213610.8CHAT, SLC6A4, TH
22regulation of membrane repolarizationGO:006030610.8KCNH2, KCNQ1
23cellular response to drugGO:003569010.8KCNH2, KCNQ1, TH
24regulation of heart rate by cardiac conductionGO:008609110.8KCNH2, KCNQ1, SCN5A
25regulation of heart contractionGO:000801610.8CAV3, KCNQ1, TH
26regulation of heart rateGO:000202710.8CAV3, GPD1L, SCN5A, SNTA1
27regulation of ventricular cardiac muscle cell membrane depolarizationGO:006037310.8CAV3, GPD1L, SCN5A
28serotonin receptor signaling pathwayGO:000721010.7HTR1A, HTR2A
29regulation of ion transmembrane transportGO:003476510.6KCNH2, KCNJ8, KCNQ1, SCN5A
30social behaviorGO:003517610.6EN1, SLC6A4, TH
31vasoconstrictionGO:004231010.6HTR1A, SLC6A4
32regulation of ventricular cardiac muscle cell membrane repolarizationGO:006030710.5CAV3, KCNH2, KCNQ1, SCN5A, SNTA1
33ventricular cardiac muscle cell action potentialGO:00860059.9CAV3, GPD1L, KCNH2, KCNQ1, SCN5A, SNTA1

Molecular functions related to Sudden Infant Death Syndrome according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1delayed rectifier potassium channel activityGO:000525110.9KCNH2, KCNQ1
2nitric-oxide synthase bindingGO:005099810.8CAV3, SCN5A, SLC6A4, SNTA1
3serotonin bindingGO:005137810.8HTR1A, HTR2A
4scaffold protein bindingGO:009711010.7KCNH2, KCNQ1, SCN5A
5sodium channel regulator activityGO:001708010.7CAV3, GPD1L, SCN5A, SNTA1
6ion channel bindingGO:004432510.7CAV3, GPD1L, KCNQ1, SCN5A, SNTA1
7oxidoreductase activityGO:001649110.5ACADM, GPD1L, MAOA, MT-ND1, TH
8voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarizationGO:008600810.4KCNH2, KCNQ1
9voltage-gated ion channel activityGO:000524410.4KCNH2, KCNJ8, KCNQ1, SCN5A
10voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationGO:190228210.1KCNH2, KCNJ8, KCNQ1

Sources for Sudden Infant Death Syndrome

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet