SIDS
MCID: SDD001
MIFTS: 70

Sudden Infant Death Syndrome (SIDS) malady

Summaries for Sudden Infant Death Syndrome

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Sudden infant death syndrome (sids) is the sudden, unexplained death of an infant younger than one year old. some people call sids "crib death" because many babies who die of sids are found in their cribs. sids is the leading cause of death in children between one month and one year old. most sids deaths occur when babies are between two months and four months old. premature babies, boys, african americans, and american indian/alaska native infants have a higher risk of sids. although health care professionals don't know what causes sids, they do know ways to reduce the risk. these include placing babies on their backs to sleep, even for short naps. "tummy time" is for when babies are awake and someone is watching using a firm sleep surface, such as a crib mattress covered with a fitted sheet keeping soft objects and loose bedding away from sleep area making sure babies don't get too hot. keep the room at a comfortable temperature for an adult. nih: national institute of child health and human development

MalaCards: Sudden Infant Death Syndrome, also known as sudden infant death syndrome, susceptibility to, is related to long qt syndrome and medium-chain acyl-coenzyme a dehydrogenase deficiency. An important gene associated with Sudden Infant Death Syndrome is SCN5A (sodium channel, voltage-gated, type V, alpha subunit), and among its related pathways are Antiarrhythmic Pathway, Pharmacodynamics and Potassium Channels. The compounds verapamil and haloperidol have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and testes, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Disease Ontology:8 A syndrome that is characterized by the sudden death of an infant that is not predicted by medical history and remains unexplained after a thorough forensic autopsy and detailed death scene investigation.

CDC:3 NIH and CDC launch registry for sudden death in the young

Wikipedia:63 Sudden infant death syndrome (SIDS) also known as cot death or crib death is the sudden death of an... more...

Description from OMIM:46 272120

Aliases & Classifications for Sudden Infant Death Syndrome

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

sudden infant death syndrome 8 42 46 10 44 33 60
sudden infant death syndrome, susceptibility to 9 22
sids 8 42
sudden death of nonspecific cause in infancy 8
sudden infant death syndrome nos 8
crib death 8
cot death 8


External Ids:

Disease Ontology8 DOID:9007
OMIM46 272120
NCIt39 C85173
MeSH34 D013398
ICD9CM27 798.0

Related Diseases for Sudden Infant Death Syndrome

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17GeneCards, 18GeneDecks
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Diseases in the Sudden Infant Death Syndrome family:

Cav3-Related Sudden Infant Death Syndrome

Diseases related to Sudden Infant Death Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1long qt syndrome31.1SNTA1, SCN5A, CAV3, KCNH2
2medium-chain acyl-coenzyme a dehydrogenase deficiency30.4ACADM, ACADS
3ischemia30.2KCNJ8, SCN5A, TH, ADCYAP1
4brugada syndrome29.9GPD1L, SCN5A, KCNH2
5neuronitis10.7
6infant botulism10.5
7botulism10.5
8congenital central hypoventilation syndrome10.5
9cerebritis10.4
10laryngitis10.4
11hyperekplexia10.4
12cav3-related sudden infant death syndrome10.4
13reye syndrome10.3
14hypophosphatemia10.3
15toxic shock syndrome10.3
16myocarditis10.3
17pneumonia10.3
18munchausen by proxy10.2
19desquamative interstitial pneumonia10.2
20bronchiolitis10.2
21hypohidrotic ectodermal dysplasia10.2
22prostate embryonal rhabdomyosarcoma10.2
23lactose intolerance10.2
24nasopharyngitis10.2
25fetal alcohol syndrome10.2
26adult syndrome10.2
27down syndrome10.2
28short qt syndrome10.2
29hypertrophic pyloric stenosis10.2
30asthma10.2
31embryonal rhabdomyosarcoma10.2
32eosinophilia10.2
33hepatitis10.2
34influenza10.2
35intellectual disability10.2
36legionellosis10.2
37mediastinitis10.2
38meningitis10.2
39opiate dependence10.2
40prostate rhabdomyosarcoma10.2
41prostatitis10.2
42pulmonary eosinophilia10.2
43pyloric stenosis10.2
44rhabdomyosarcoma10.2
45x-linked disease10.2
46micro syndrome10.2
47infantile histiocytoid cardiomyopathy10.2
48sudden infant death with dysgenesis of the testes syndrome10.2
49sudden cardiac death multi-gene panels10.0KCNH2, CAV3, SCN5A, ACADM, TSPYL1
50acute myocardial infarction10.0SLC6A4

Graphical network of the top 20 diseases related to Sudden Infant Death Syndrome:



Diseases related to sudden infant death syndrome

Clinical Features for Sudden Infant Death Syndrome

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46OMIM
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Clinical features from OMIM:

272120

Clinical synopsis from OMIM:

272120

Drugs & Therapeutics for Sudden Infant Death Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Sudden Infant Death Syndrome

Drug clinical trials:

Search ClinicalTrials for Sudden Infant Death Syndrome

Search NIH Clinical Center for Sudden Infant Death Syndrome

Search CenterWatch for Sudden Infant Death Syndrome

Genetic Tests for Sudden Infant Death Syndrome

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22GTR
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Genetic tests related to Sudden Infant Death Syndrome:

id Genetic test Affiliating Genes
1 Sudden Infant Death Syndrome22

Anatomical Context for Sudden Infant Death Syndrome

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32MalaCards
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MalaCards organs/tissues related to Sudden Infant Death Syndrome:

32
Brain, Heart, Testes, Lung, Breast, Liver, Placenta, Prostate, Hypothalamus, Colon, Smooth muscle, Pituitary, Endothelial, Whole blood, Eye, Medulla oblongata

Animal Models for Sudden Infant Death Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sudden Infant Death Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.6EN1, KCNJ8, KCNH2, CAV3, UCP1, SCN5A
2MP:000537610.6C4B, PHOX2B, UCP1, CAV3, KCNH2, SNTA1
3MP:000536910.5KCNH2, CAV3, SCN5A, SNTA1, SLC6A4, ACADM
4MP:000537810.5IDS, UCP1, SCN5A, PHOX2B, TH, SLC6A4
5MP:001076810.5PHOX2B, SCN5A, IDS, KCNH2, KCNJ8, C4B
6MP:000538610.4IDS, UCP1, SCN5A, PHOX2B, SNTA1, TH
7MP:000538410.2CAV3, IDS, UCP1, SCN5A, PHOX2B, TH

Publications for Sudden Infant Death Syndrome

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Sources:
50PubMed
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Articles related to Sudden Infant Death Syndrome:

(show top 50)    (show all 571)
idTitleAuthorsYear
1
Serotonin metabolites in the cerebrospinal fluid in sudden infant death syndrome. (24423636)
2014
2
Sudden Infant Death Syndrome (SIDS) risk reduction and infant sleep location - moving the discussion forward. (22571891)
2013
3
Functional single-nucleotide variant of HSPD1 in sudden infant death syndrome. (23823174)
2013
4
Maternal alcohol use and sudden infant death syndrome and infant mortality excluding SIDS. (23439895)
2013
5
Postmortem review and genetic analysis in sudden infant death syndrome: an 11-year review. (23623143)
2013
6
The dorsal motor nucleus of the vagus (DMNV) in sudden infant death syndrome (SIDS): pathways leading to apoptosis. (22975482)
2013
7
Monoamine oxidase A gene polymorphism and the pathogenesis of sudden infant death syndrome. (23391042)
2013
8
Trends in socioeconomic inequalities in risk of sudden infant death syndrome, other causes of infant mortality, and stillbirth in Scotland: population based study. (22427307)
2012
9
Cardiac channelopathies and sudden infant death syndrome. (21778721)
2011
10
Human cardioviruses, meningitis, and sudden infant death syndrome in children. (22153118)
2011
11
The gliocentric hypothesis of the pathophysiology of the sudden infant death syndrome (SIDS). (21159448)
2011
12
Next steps in the study of sudden infant death syndrome. (21503379)
2011
13
Cardiac muscarinic receptor overexpression in sudden infant death syndrome. (20209124)
2010
14
The A, B, Cs of sudden infant death syndrome: an electrical disorder? (20176136)
2010
15
Sudden infant death syndrome (SIDS) in African Americans: polymorphisms in the gene encoding the stress peptide pituitary adenylate cyclase-activating polypeptide (PACAP). (19120039)
2009
16
Sudden infant death syndrome. (20032331)
2009
17
Sudden infant death syndrome. (19496386)
2009
18
Sudden infant death syndrome and prone sleeping position. (19344862)
2009
19
The effect of maternal smoking and drinking during pregnancy upon (3)H-nicotine receptor brainstem binding in infants dying of the sudden infant death syndrome: initial observations in a high risk population. (17924983)
2008
20
Sudden infant death syndrome: changing epidemiologic patterns in California 1989-2004. (18534214)
2008
21
Sudden infant death syndrome is associated with parental psychiatric admission. (18669694)
2008
22
Sudden infant death syndrome in Brazil: fact or fancy? (18425287)
2008
23
Novel mechanism for sudden infant death syndrome: persistent late sodium current secondary to mutations in caveolin-3. (17275750)
2007
24
Pulmonary neuroendocrine cells and neuroepithelial bodies in sudden infant death syndrome: potential markers of airway chemoreceptor dysfunction. (17378691)
2007
25
An audit of the use of definitions of sudden infant death syndrome (SIDS). (17961869)
2007
26
Sudden Infant Death Syndrome and parental smoking. (17881163)
2007
27
Sudden infant death syndrome and long QT syndrome: the zealots versus the naysayers. (17275751)
2007
28
Commentary on: Alexander RT, Radisch D. Sudden infant death syndrome risk factors with regards to sleep position, sleep surface, and co-sleeping. J Forensic Sci 2005;50:1-5. (16566786)
2006
29
Sudden infant death syndrome: risk factors for infants found face down differ from other SIDS cases. (17095333)
2006
30
Unexpected perinatal death and sudden infant death syndrome (SIDS): anatomopathologic and legal aspects. (15894850)
2005
31
Awareness of sudden infant death syndrome needed in Nepal. (16295728)
2005
32
Inhibition of serotonergic neurons in the nucleus paragigantocellularis lateralis fragments sleep and decreases rapid eye movement sleep in the piglet: implications for sudden infant death syndrome. (16148240)
2005
33
Possible pathomechanisms of sudden infant death syndrome: key role of chronic hypoxia, infection/inflammation states, cytokine irregularities, and metabolic trauma in genetically predisposed infants. (15543094)
2004
34
Second-trimester maternal serum levels of alpha-fetoprotein and the subsequent risk of sudden infant death syndrome. (15342806)
2004
35
Seasonal variation of sudden infant death syndrome in Hawaii. (15483306)
2004
36
Interleukin-10 and sudden infant death syndrome. (15325406)
2004
37
Interleukin 10 genotype as a risk factor for sudden infant death syndrome: determination of IL-10 genotype from wax-embedded postmortem samples. (15325405)
2004
38
Infection and food: a factor in sudden infant death syndrome? (15325399)
2004
39
Sudden infant death syndrome and social deprivation: assessing epidemiological factors after post-matching for deprivation. (12839539)
2003
40
Sudden infant death syndrome: a cybernetic etiology. (14592795)
2003
41
Sudden infant death syndrome. (15555102)
2003
42
Are risk factors for sudden infant death syndrome different at night? (12243991)
2002
43
Sudden infant death syndrome, bedsharing, parental weight, and age at death. (11230594)
2001
44
Molecular diagnosis in a child with sudden infant death syndrome. (11684219)
2001
45
A molecular link between the sudden infant death syndrome and the long-QT syndrome. (10911008)
2000
46
Ontogenesis of CYP2C-dependent arachidonic acid metabolism in the human liver: relationship with sudden infant death syndrome. (10813596)
2000
47
Proliferation of dendritic cells in the bronchioles of sudden infant death syndrome victims. (8346185)
1993
48
Inherited metabolic diseases in the sudden infant death syndrome. (1755645)
1991
49
Honey, infant botulism and the sudden infant death syndrome. (7376645)
1980
50
In utero opiate dependence and sudden infant death syndrome. (383362)
1979

Genetic Variations for Sudden Infant Death Syndrome

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Sudden Infant Death Syndrome:

62 (show all 11)
id Symbol AA change Variation ID SNP ID
1CAV3p.Val14LeuVAR_043694rs121909281
2CAV3p.Thr78MetVAR_043695rs72546668
3CAV3p.Leu79ArgVAR_043696
4GPD1Lp.Glu83LysVAR_044044
5GPD1Lp.Ile124ValVAR_044045rs72552293
6GPD1Lp.Arg273CysVAR_044046
7KCNJ8p.Val346IleVAR_065879
8SCN5Ap.Ser1333TyrVAR_036666
9SCN5Ap.Phe532CysVAR_055177
10SCN5Ap.Gly1084SerVAR_055185
11SCN5Ap.Phe1705SerVAR_055207

Expression for genes affiliated with Sudden Infant Death Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sudden Infant Death Syndrome

Search GEO for disease gene expression data for Sudden Infant Death Syndrome.

Pathways for genes affiliated with Sudden Infant Death Syndrome

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49PharmGKB, 53Reactome, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Sudden Infant Death Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5SCN5A, KCNH2, KCNJ8
2
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10.5SLC6A4, KCNH2, KCNJ8
3
Hide members
10.5ECHS1, ACADM
4
Hide members
10.5ACADS, ACADM, SLC25A20, TH, GPD1L
510.5ADCYAP1, KCNJ8, KCNH2, CAV3, SCN5A, PHOX2B
6
Hide members
10.5ACADS, ACADM, ECHS1
7
Hide members
10.5ECHS1, GPD1L, SLC25A20, ACADM, ACADS
8
Hide members
10.4ECHS1, SLC25A20, ACADM, ACADS

Compounds for genes affiliated with Sudden Infant Death Syndrome

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Sudden Infant Death Syndrome according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1verapamil44 49 28 11 2414.9KCNH2, SCN5A, TH, SLC6A4
2haloperidol44 28 2 49 1114.9KCNH2, TH, SLC6A4, ADCYAP1
3cocaine44 1111.9KCNH2, SCN5A, TH, SLC6A4
4arginine4410.9KCNH2, SCN5A, C4A, SLC25A20, SLC6A4, ACADM
5Octanoyl-Coenzyme A1110.9ACADM, ECHS1
6norepinephrine44 11 2412.9UCP1, PHOX2B, TH, SLC6A4, ADCYAP1
7cocaethylene4410.9KCNH2, SLC6A4
8carnitine4410.9ACADS, ACADM, SLC25A20, UCP1
9sodium44 2411.9KCNH2, CAV3, SCN5A, SNTA1, SLC6A4
10mazindol44 28 1112.9SLC6A4, TH
11fatty acid4410.9ADCYAP1, CAV3, UCP1, ECHS1, SLC25A20, ACADM
12Acetoacetyl-Coenzyme A1110.9ECHS1, ACADS
13flecainide44 49 28 1113.9SCN5A, KCNH2
14alanine4410.9KCNH2, UCP1, SCN5A, PHOX2B, TH, SLC6A4
15aspartate4410.9UCP1, SCN5A, TH, SLC6A4, ADCYAP1
16glutamate4410.9UCP1, TH, SLC6A4, ACADM, ACADS, ADCYAP1
17tetrodotoxin44 59 2812.9SCN5A, TH, ADCYAP1
18mexiletine44 1111.9KCNH2, SCN5A
19serine4410.9KCNH2, UCP1, SCN5A, C4A, C4B, SLC6A4
20propafenone44 49 28 1113.9KCNH2, SCN5A
21d amphetamine4410.9TH, SLC6A4
22cyclic amp44 2411.8KCNH2, UCP1, PHOX2B, TH, ADCYAP1
23mdma4410.8TH, SLC6A4
24Intravenous Immunoglobulin1110.8C4B, C4A
253-methylcrotonyl-coa44 2411.8ECHS1, ACADM
26oxygen44 2411.8KCNH2, UCP1, C4A, TH, ACADM, ADCYAP1
27acyl-coa4410.8SLC25A20, ACADM, ACADS
28(2E)-Tetradecenoyl-CoA2410.8ECHS1, ACADM, ACADS
29(2E)-Octenoyl-CoA2410.8ECHS1, ACADM, ACADS
30corticosterone44 59 2412.8ADCYAP1, SLC6A4, TH
31(2E)-Dodecenoyl-CoA2410.8ECHS1, ACADM, ACADS
32(2E)-Decenoyl-CoA2410.8ACADS, ACADM, ECHS1
33(2E)-Hexadecenoyl-CoA2410.7ACADS, ACADM, ECHS1
34testosterone44 59 11 2413.7KCNH2, UCP1, TH, SLC6A4, ADCYAP1
35catecholamine4410.7ADCYAP1, TH, UCP1
36trazodone44 28 1112.7KCNH2, SLC6A4
375-hydroxytryptophan4410.7SLC6A4, TH
38mhpg4410.7SLC6A4, TH
39methylphenidate44 49 1112.7SLC6A4, TH
40steroid4410.7KCNH2, IDS, C4A, C4B, ADCYAP1
41calcium44 49 11 2413.6KCNH2, CAV3, IDS, UCP1, SCN5A, C4B
42nimodipine44 28 1112.6TH, ADCYAP1
43maoa4410.5TH, SLC6A4
44potassium44 11 2412.5KCNJ8, KCNH2, SCN5A, ADCYAP1
45homovanillic acid44 2411.5SLC6A4, TH
46cisapride44 28 1112.4SCN5A, KCNH2
47bamhi4410.2ACADM, C4A

GO Terms for genes affiliated with Sudden Infant Death Syndrome

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16Gene Ontology
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Cellular components related to Sudden Infant Death Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrionGO:00573910.4UCP1, ECHS1, TH, SLC25A20, ACADM, ACADS
2sarcolemmaGO:04238310.2SNTA1, SCN5A, CAV3, KCNJ8

Biological processes related to Sudden Infant Death Syndrome according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of ventricular cardiac muscle cell action potentialGO:08600510.8GPD1L, SNTA1, SCN5A, CAV3, KCNH2
2regulation of ventricular cardiac muscle cell membrane repolarizationGO:06030710.8KCNH2, CAV3, SCN5A, SNTA1
3regulation of heart rateGO:00202710.8GPD1L, SNTA1, SCN5A, CAV3
4regulation of ventricular cardiac muscle cell membrane depolarizationGO:06037310.8CAV3, SCN5A, GPD1L
5cellular lipid metabolic processGO:04425510.7ACADS, ACADM, SLC25A20, GPD1L, ECHS1
6response to starvationGO:04259410.7ACADM, ACADS, ADCYAP1
7small molecule metabolic processGO:04428110.7IDS, UCP1, ECHS1, GPD1L, TH, SLC25A20
8fatty acid beta-oxidationGO:00663510.7ACADS, ACADM, ECHS1
9negative regulation of potassium ion transmembrane transportGO:190138010.7KCNH2, CAV3
10membrane depolarization involved in regulation of action potentialGO:08601010.6KCNH2, SCN5A
11regulation of sodium ion transmembrane transportGO:190230510.6SCN5A, SNTA1
12fatty acid beta-oxidation using acyl-CoA dehydrogenaseGO:03353910.5ACADM, ACADS
13brainstem developmentGO:00336010.5SCN5A, PHOX2B
14regulation of heart rate by cardiac conductionGO:08609110.5SCN5A, KCNH2
15regulation of sodium ion transmembrane transporter activityGO:200064910.4GPD1L, CAV3
16positive regulation of sodium ion transportGO:01076510.2GPD1L, SCN5A

Molecular functions related to Sudden Infant Death Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nitric-oxide synthase bindingGO:05099810.6SLC6A4, SNTA1, SCN5A, CAV3
2ion channel bindingGO:04432510.5CAV3, SCN5A, SNTA1, GPD1L
3inward rectifier potassium channel activityGO:00524210.5KCNH2, KCNJ8
4sodium channel regulator activityGO:01708010.4GPD1L, SNTA1, CAV3
5acyl-CoA dehydrogenase activityGO:00399510.2ACADS, ACADM

Products for genes affiliated with Sudden Infant Death Syndrome

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Sources for Sudden Infant Death Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet