MCID: SPR005
MIFTS: 43

Superficial Basal Cell Carcinoma malady

Cancer diseases category

Summaries for Superficial Basal Cell Carcinoma

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32MalaCards
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MalaCards: Superficial Basal Cell Carcinoma, also known as multifocal superficial basal cell carcinoma, is related to basal cell carcinoma and actinic keratosis. An important gene associated with Superficial Basal Cell Carcinoma is DLL1 (delta-like 1 (Drosophila)), and among its related pathways are Presenilin action in Notch and Wnt signaling and Notch signaling pathway. The compounds loxoribine and resiquimod have been mentioned in the context of this disorder. Affiliated tissues include skin and t cells, and related mouse phenotypes are hearing/vestibular/ear and renal/urinary system.

Aliases & Classifications for Superficial Basal Cell Carcinoma

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8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

superficial basal cell carcinoma 8 60
multifocal superficial basal cell carcinoma 8 60
superficial multicentric basal-cell carcinoma 8
multicentric basal cell carcinoma 8


External Ids:

Disease Ontology8 DOID:4300
SNOMED-CT56 61098004
NCIt39 C4108

Related Diseases for Superficial Basal Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Superficial Basal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1basal cell carcinoma31.7TLR7
2actinic keratosis30.5TLR7
3melanoma30.2TLR7, IFNA1, MME, NOTCH1, BCL2
4nodular basal cell carcinoma10.5
5large cell carcinoma10.5
6in situ carcinoma10.5
7squamous cell carcinoma10.5
8small cell carcinoma10.4
9keratosis10.4
10pigmented basal cell carcinoma10.4
11scrotum basal cell carcinoma10.4
12vitiligo10.4
13epidermolytic hyperkeratosis10.2
14infiltrative basal cell carcinoma10.2
15dermatitis10.2
16psoriasis10.2
17keratoacanthoma10.2
18rheumatoid arthritis10.0MME
19kidney cancer10.0IFNA1
20hepatitis b10.0IFNA1
21hepatitis10.0IFNA1
22acute leukemia10.0NOTCH1
23cryoglobulinemic vasculitis10.0IFNA1
24asthma10.0MME
25pneumonia10.0MME
26choriocarcinoma10.0MME
27smooth muscle tumor10.0MME
28lupus erythematosus10.0TLR7
29glomerulonephritis10.0MME
30cryoglobulinemia10.0IFNA1
31myeloid leukemia10.0BCL2
32lung cancer10.0BCL2
33hepatitis c10.0TLR7, IFNA1
34cadasil10.0NOTCH1, JAG1
35alagille syndrome10.0NOTCH1, JAG1
36glioblastoma multiforme10.0BCL2
37deficiency anemia10.0IFNA1, MME
38colon adenocarcinoma10.0BCL2
39wilms tumor10.0NOTCH1, MME
40stomach cancer10.0BCL2, JAG1
41b-cell chronic lymphocytic leukemia10.0MME, BCL2
42lymphoma, diffuse large cell10.0BCL2, MME
43colorectal cancer10.0BCL2, IFNA1
44endometrial carcinoma10.0BCL2, MME
45multiple sclerosis10.0MME, JAG1, IFNA1
46galactosemia10.0MME, JAG1, IFNA1
47hypertension10.0NOTCH1, MME
48viral infectious disease10.0MME, IFNA1, TLR7
49follicular lymphoma10.0MME, BCL2
50burkitt's lymphoma10.0IFNA1, MME, BCL2

Graphical network of the top 20 diseases related to Superficial Basal Cell Carcinoma:



Diseases related to superficial basal cell carcinoma

Clinical Features for Superficial Basal Cell Carcinoma

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Drugs & Therapeutics for Superficial Basal Cell Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Superficial Basal Cell Carcinoma

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Anatomical Context for Superficial Basal Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Superficial Basal Cell Carcinoma:

32
Skin, T cells

Animal Models for Superficial Basal Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Superficial Basal Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537710.0NOTCH1
2MP:00053679.4DLL1, JAG1, TLR7
3MP:00053768.7TLR7, JAG1, DLL1, NOTCH1
4MP:00053818.1JAG1, DLL1, NOTCH1, BCL2
5MP:00053697.9JAG1, DLL1, NOTCH1, BCL2
6MP:00053977.8BCL2, NOTCH1, DLL1, JAG1, TLR7
7MP:00053877.7BCL2, NOTCH1, MME, DLL1, TLR7

Publications for Superficial Basal Cell Carcinoma

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50PubMed
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Articles related to Superficial Basal Cell Carcinoma:

(show top 50)    (show all 101)
idTitleAuthorsYear
1
Accuracy of dermoscopic criteria for discriminating superficial from other subtypes of basal cell carcinoma. (24268311)
2014
2
Aesthetic evaluation after non-invasive treatment for superficial basal cell carcinoma. (22103716)
2013
3
Dermal changes in superficial basal cell carcinoma, melanoma in situ and actinic keratosis and their implications. (24117926)
2013
4
Multiple superficial and pigmented basal cell carcinomas: do these represent a type of multiple non-syndromic basal cell carcinoma? (24117161)
2013
5
Combined Carbon Dioxide Laser with Photodynamic Therapy for Nodular and Superficial Basal Cell Carcinoma: Almost Scarless Cure With Minimal Recurrence. (23407256)
2013
6
Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial. (23683751)
2013
7
Thickness of superficial basal cell carcinoma (sBCC) predicts imiquimod efficacy: a proposal for a thickness-based definition of sBCC. (23627639)
2013
8
Chronicle of a pigmented superficial Basal cell carcinoma. (23259087)
2012
9
Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened. (21558397)
2011
10
PEP005 (ingenol mebutate) gel for the topical treatment of superficial basal cell carcinoma: results of a randomized phase IIa trial. (20546215)
2010
11
A cost analysis of photodynamic therapy with methyl aminolevulinate and imiquimod compared with conventional surgery for the treatment of superficial basal cell carcinoma and Bowen's disease of the lower extremities. (20456549)
2010
12
Superficial basal cell carcinoma treated with imiquimod 5% topical cream for a 4-week period: a case series. (19646136)
2009
13
Management of superficial basal cell carcinoma: focus on imiquimod. (21436969)
2009
14
Photodynamic therapy using methyl aminolevulinate in the management of primary superficial basal cell carcinoma: clinical and health economic outcomes. (19894366)
2009
15
Photodynamic therapy for the treatment of a giant superficial basal cell carcinoma. (19152518)
2009
16
Methyl aminolaevulinate-photodynamic therapy for actinic keratoses, squamous cell carcinoma in situ and superficial basal cell carcinoma employing a square wave intense pulsed light device for photoactivation. (19416229)
2009
17
Giant superficial basal cell carcinoma treated with cryosurgery. (18657160)
2008
18
Confirmation of histological clearance of superficial basal cell carcinoma with multiple serial sectioning and Mohs' micrographic surgery following treatment with imiquimod 5% cream. (18569271)
2008
19
Recurrence rate of superficial basal cell carcinoma following treatment with imiquimod 5% cream: conclusion of a 5-year long-term follow-up study in Europe. (18955210)
2008
20
A randomized parallel study to assess the safety and efficacy of two different dosing regimens of 5% imiquimod in the treatment of superficial basal cell carcinoma. (17917935)
2008
21
Induction of the members of Notch pathway in superficial basal cell carcinomas treated with imiquimod. (17922128)
2007
22
Efficacy of photodynamic therapy with methyl aminolevulinate in the treatment of superficial and nodular basal cell carcinoma: an open-label trial. (17673385)
2007
23
CD-10 immunostaining differentiates superficial basal cell carcinoma from cutaneous squamous cell carcinoma. (18032951)
2007
24
Radial streaking: unusual dermoscopic pattern in pigmented superficial basal cell carcinoma. (17894724)
2007
25
Cost-effectiveness of treatment of superficial basal cell carcinoma: surgical excision vs. imiquimod 5% cream. (17263811)
2007
26
Epidermoid cysts mimicking recurrence of superficial basal cell carcinoma following photodynamic therapy. (17137478)
2007
27
Management of primary superficial basal cell carcinoma. (16751865)
2006
28
Photodynamic therapy for superficial basal cell carcinoma and Bowen's disease. (16436340)
2006
29
Clinical and histopathologic findings of superficial basal cell carcinoma: A comparison with other basal cell carcinoma subtypes. (16970272)
2006
30
Fractionated illumination significantly improves the response of superficial basal cell carcinoma to aminolevulinic acid photodynamic therapy. (16841035)
2006
31
Topical 5-aminolevulinic acid mediated photodynamic therapy of superficial basal cell carcinoma using two light fractions with a two-hour interval: long-term follow-up. (16955185)
2006
32
Imiquimod treatment of superficial and nodular basal cell carcinoma: 12-week open-label trial. (15841634)
2005
33
Dermoscopic monitoring of tazarotene treatment of superficial basal cell carcinoma. (15762218)
2005
34
595 nm pulsed dye laser for the treatment of superficial basal cell carcinoma. (16328096)
2005
35
Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from a randomized vehicle-controlled phase III study in Europe. (15888150)
2005
36
A case of penile superficial basal cell carcinoma involving the inner surface of foreskin. (16303075)
2005
37
Treatment of an extensive superficial basal cell carcinoma of the face with imiquimod 5% cream. (16372477)
2005
38
Dermoscopy of superficial basal cell carcinoma. (16336893)
2005
39
5% imiquimod cream for the treatment of large superficial basal cell carcinoma. (15492202)
2004
40
Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from two phase III, randomized, vehicle-controlled studies. (15097956)
2004
41
Pulsed dye laser treatment of superficial basal cell carcinoma: realistic or not? (12928824)
2003
42
Imiquimod 5% cream for the treatment of superficial and nodular basal cell carcinoma: randomized studies comparing low-frequency dosing with and without occlusion. (12452875)
2002
43
Photodynamic therapy of superficial basal cell carcinoma with 5-aminolevulinic acid with dimethylsulfoxide and ethylendiaminetetraacetic acid: a comparison of two light sources. (10857368)
2000
44
Therapeutic options for superficial basal cell carcinoma: the role of radiation therapy. (9645651)
1998
45
When to suspect superficial basal cell carcinoma. (9823392)
1998
46
Photodynamic therapy of superficial basal cell carcinoma by instillation of aminolevulinic acid and irradiation with visible light. (9420532)
1997
47
Epidermolytic hyperkeratosis associated with superficial basal cell carcinoma. (6824352)
1983
48
Superficial basal cell carcinoma of 32 years' duration. (281535)
1978
49
The histological findings in normal skin and multiple superficial basal cell carcinoma treated with an ointment containing demecolcine. (14406310)
1959
50
Superficial Basal-cell Carcinoma. (19992640)
1943

Genetic Variations for Superficial Basal Cell Carcinoma

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Expression for genes affiliated with Superficial Basal Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Superficial Basal Cell Carcinoma

Search GEO for disease gene expression data for Superficial Basal Cell Carcinoma.

Pathways for genes affiliated with Superficial Basal Cell Carcinoma

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37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology, 53Reactome, 51QIAGEN, 12EMD Millipore, 52R&D Systems
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Pathways related to Superficial Basal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5NOTCH1, DLL1
2
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9.1NOTCH1, DLL1, JAG1
39.1JAG1, DLL1, NOTCH1
4
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9.1JAG1, DLL1, NOTCH1
5
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9.1JAG1, DLL1, NOTCH1
6
Hide members
9.1NOTCH1, DLL1, JAG1
7
Hide members
9.1JAG1, DLL1, NOTCH1
8
Hide members
9.1NOTCH1, DLL1, JAG1
99.1JAG1, DLL1, NOTCH1
10
Hide members
8.7BCL2, IFNA1, TLR7
118.2BCL2, NOTCH1, DLL1, JAG1

Compounds for genes affiliated with Superficial Basal Cell Carcinoma

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Superficial Basal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1loxoribine44 2810.8IFNA1, TLR7
2resiquimod44 5910.8IFNA1, TLR7
3imiquimod44 28 59 1112.7IFNA1, TLR7
4polyinosinic-polycytidylic acid449.6IFNA1, TLR7
5ginsenoside449.4BCL2, MME
6poly(i-c)449.4TLR7, IFNA1
7dacarbazine44 1110.4BCL2, IFNA1
82-chlorodeoxyadenosine449.3IFNA1, BCL2
9fludarabine44 1110.1BCL2, IFNA1
10cytarabine44 49 1110.9IFNA1, MME, BCL2
11adriamycin448.9IFNA1, MME, BCL2
12mitoxantrone44 49 1110.8IFNA1, BCL2
13rapamycin448.6IFNA1, NOTCH1, BCL2
14actinomycin d448.6BCL2, MME, IFNA1
15doxorubicin44 49 1110.3BCL2, NOTCH1, MME, IFNA1
16dexamethasone44 49 28 1111.2IFNA1, MME, NOTCH1, BCL2
17vegf448.2IFNA1, MME, NOTCH1, BCL2
18retinoic acid44 249.1BCL2, NOTCH1, MME, IFNA1

GO Terms for genes affiliated with Superficial Basal Cell Carcinoma

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16Gene Ontology
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Biological processes related to Superficial Basal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1loop of Henle developmentGO:07207010.0JAG1, DLL1
2cell fate determinationGO:0017099.9DLL1, JAG1
3positive regulation of Notch signaling pathwayGO:0457479.9DLL1, JAG1
4compartment pattern specificationGO:0073869.8NOTCH1, DLL1
5distal tubule developmentGO:0720179.8NOTCH1, JAG1
6negative regulation of stem cell differentiationGO:20007379.8JAG1, NOTCH1
7left/right axis specificationGO:0709869.8NOTCH1, DLL1
8cardiac septum morphogenesisGO:0604119.8NOTCH1, JAG1
9pulmonary valve morphogenesisGO:0031849.7JAG1, NOTCH1
10Notch signaling involved in heart developmentGO:0613149.7NOTCH1, JAG1
11response to muramyl dipeptideGO:0324959.7NOTCH1, JAG1
12determination of left/right symmetryGO:0073689.5NOTCH1, DLL1
13heart loopingGO:0019479.5DLL1, NOTCH1
14neuronal stem cell maintenanceGO:0971509.4NOTCH1, DLL1, JAG1
15Notch receptor processingGO:0072209.4NOTCH1, DLL1, JAG1
16hemopoiesisGO:0300979.4DLL1, JAG1
17mesenchymal cell developmentGO:0140319.4NOTCH1, BCL2
18keratinocyte differentiationGO:0302169.3NOTCH1, JAG1
19Notch signaling pathwayGO:0072199.3JAG1, DLL1, NOTCH1
20negative regulation of anoikisGO:20008119.3NOTCH1, BCL2
21negative regulation of ossificationGO:0302799.2NOTCH1, BCL2
22hair follicle morphogenesisGO:0310699.2NOTCH1, BCL2
23humoral immune responseGO:0069599.1BCL2, NOTCH1
24axonogenesisGO:0074099.0BCL2, NOTCH1

Molecular functions related to Superficial Basal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Notch bindingGO:0051129.7DLL1, JAG1

Products for genes affiliated with Superficial Basal Cell Carcinoma

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Sources for Superficial Basal Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet