MCID: SPR005
MIFTS: 39

Superficial Basal Cell Carcinoma malady

Cancer category

Summaries for Superficial Basal Cell Carcinoma

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33MalaCards
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MalaCards: Superficial Basal Cell Carcinoma, also known as multifocal superficial basal cell carcinoma, is related to basal cell carcinoma and actinic keratosis. An important gene associated with Superficial Basal Cell Carcinoma is DLL1 (delta-like 1 (Drosophila)), and among its related pathways are Presenilin action in Notch and Wnt signaling and Notch signaling pathway. The compounds loxoribine and resiquimod have been mentioned in the context of this disorder. Affiliated tissues include skin and t cells, and related mouse phenotypes are hearing/vestibular/ear and renal/urinary system.

Aliases & Classifications for Superficial Basal Cell Carcinoma

Sources:
8Disease Ontology, 61UMLS, 40NCIt, 57SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

superficial basal cell carcinoma 8 61
multifocal superficial basal cell carcinoma 8 61
superficial multicentric basal-cell carcinoma 8
multicentric basal cell carcinoma 8


External Ids:

Disease Ontology8 DOID:4300
SNOMED-CT57 61098004
NCIt40 C4108

Related Diseases for Superficial Basal Cell Carcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Superficial Basal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1basal cell carcinoma31.8TLR7
2actinic keratosis30.5TLR7
3nodular basal cell carcinoma10.5
4large cell carcinoma10.5
5squamous cell carcinoma10.5
6small cell carcinoma10.5
7basal cell carcinoma, multiple10.5
8pigmented basal cell carcinoma10.4
9scrotum basal cell carcinoma10.4
10vitiligo10.4
11epidermolytic hyperkeratosis10.2
12clear cell basal cell carcinoma10.2
13rheumatoid arthritis10.0MME
14kidney cancer10.0IFNA1
15hepatitis b10.0IFNA1
16hepatitis10.0IFNA1
17acute leukemia10.0NOTCH1
18cryoglobulinemic vasculitis10.0IFNA1
19asthma10.0MME
20pneumonia10.0MME
21choriocarcinoma10.0MME
22smooth muscle tumor10.0MME
23lupus erythematosus10.0TLR7
24glomerulonephritis10.0MME
25cryoglobulinemia10.0IFNA1
26myeloid leukemia10.0BCL2
27lung cancer10.0BCL2
28hepatitis c10.0TLR7, IFNA1
29cadasil10.0NOTCH1, JAG1
30alagille syndrome10.0NOTCH1, JAG1
31glioblastoma multiforme10.0BCL2
32deficiency anemia10.0IFNA1, MME
33colon adenocarcinoma10.0BCL2
34wilms tumor10.0NOTCH1, MME
35stomach cancer10.0BCL2, JAG1
36b-cell chronic lymphocytic leukemia10.0MME, BCL2
37lymphoma, diffuse large cell10.0BCL2, MME
38colorectal cancer10.0BCL2, IFNA1
39endometrial carcinoma10.0BCL2, MME
40multiple sclerosis10.0MME, JAG1, IFNA1
41galactosemia10.0MME, JAG1, IFNA1
42hypertension10.0NOTCH1, MME
43viral infectious disease10.0MME, IFNA1, TLR7
44follicular lymphoma10.0MME, BCL2
45burkitt's lymphoma10.0IFNA1, MME, BCL2
46cervical cancer10.0JAG1, NOTCH1, BCL2
47myeloma10.0BCL2, NOTCH1, IFNA1
48ovarian cancer10.0BCL2, NOTCH1, MME
49prostate cancer10.0BCL2, NOTCH1, MME
50acute lymphocytic leukemia10.0MME, NOTCH1, BCL2

Graphical network of the top 20 diseases related to Superficial Basal Cell Carcinoma:



Diseases related to superficial basal cell carcinoma

Clinical Features for Superficial Basal Cell Carcinoma

Drugs & Therapeutics for Superficial Basal Cell Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Superficial Basal Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Superficial Basal Cell Carcinoma

Search NIH Clinical Center for Superficial Basal Cell Carcinoma

Search CenterWatch for Superficial Basal Cell Carcinoma

Genetic Tests for Superficial Basal Cell Carcinoma

Anatomical Context for Superficial Basal Cell Carcinoma

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33MalaCards
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MalaCards organs/tissues related to Superficial Basal Cell Carcinoma:

33
Skin, T cells

Animal Models for Superficial Basal Cell Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Superficial Basal Cell Carcinoma

Sources:
51PubMed
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Articles related to Superficial Basal Cell Carcinoma:

(show top 50)    (show all 101)
idTitleAuthorsYear
1
Immunocryosurgery for Non-superficial Basal Cell Carcinoma: A Pro-spective, Open-label Phase III Study for Tumours a8oa882 cm in Diameter. (23722308)
2014
2
The application of axial superficial temporal artery island flap for repairing the defect secondary to the removal of the lower eyelid basal cell carcinoma. (24103434)
2014
3
Spoke wheel-like structures in superficial basal cell carcinoma: a correlation between dermoscopy, histopathology, and reflective confocal microscopy. (24124839)
2013
4
Applicability of dermoscopy for evaluation of patients' response to non-ablative therapies for the treatment of superficial basal cell carcinoma. (24283541)
2013
5
Light fractionation significantly improves the response of superficial basal cell carcinoma to aminolaevulinic acid photodynamic therapy: five-year follow-up of a randomized, prospective trial. (22964973)
2012
6
Overall treatment success after treatment of primary superficial basal cell carcinoma: a systematic review and meta-analysis of randomized and nonrandomized trials. (22612571)
2012
7
Effectiveness and satisfaction with imiquimod for the treatment of superficial basal cell carcinoma in daily dermatological practice. (21348896)
2011
8
Large superficial Basal cell carcinoma arising in the scalp. (22028585)
2011
9
A comparison in real clinical practice of methyl aminolevulinate photodynamic therapy and surgery for small superficial basal cell carcinoma: 3-year recurrence rates and cosmetic outcomes. (20456551)
2011
10
Detection of human papilloma virus in normal skin and in superficial and nodular basal cell carcinomas in immunocompetent subjects. (21054564)
2011
11
The SINS trial: a randomised controlled trial of excisional surgery versus imiquimod 5% cream for nodular and superficial basal cell carcinoma. (20409337)
2010
12
Probing tumor and peritumoral tissues in superficial and nodular basal cell carcinoma using polarized Raman microspectroscopy. (19845756)
2010
13
Superficial basal cell carcinoma treated with imiquimod 5% topical cream for a 4-week period: a case series. (19646136)
2009
14
Management of superficial basal cell carcinoma: focus on imiquimod. (21436969)
2009
15
Fractionated 5-aminolevulinic acid photodynamic therapy in the treatment of a giant recurrent superficial basal cell carcinoma. (19906170)
2009
16
Methyl aminolaevulinate-photodynamic therapy for actinic keratoses, squamous cell carcinoma in situ and superficial basal cell carcinoma employing a square wave intense pulsed light device for photoactivation. (19416229)
2009
17
A clinical study comparing methyl aminolevulinate photodynamic therapy and surgery in small superficial basal cell carcinoma (8-20 mm), with a 12-month follow-up. (18624836)
2008
18
Microscopic distribution of protoporphyrin (PpIX) fluorescence in superficial basal cell carcinoma during light-fractionated aminolaevulinic acid photodynamic therapy. (19002337)
2008
19
Dermatoscopy aids in the diagnosis of the solitary red scaly patch or plaque-features distinguishing superficial basal cell carcinoma, intraepidermal carcinoma, and psoriasis. (18550207)
2008
20
Topical methyl aminolaevulinate photodynamic therapy versus cryotherapy for superficial basal cell carcinoma: a 5 year randomized trial. (18693158)
2008
21
Vitiligo-like hypopigmentation with poliosis following treatment of superficial basal cell carcinoma with imiquimod. (18363730)
2008
22
Primary superficial basal cell carcinoma of the nipple. (17684426)
2007
23
Induction of the members of Notch pathway in superficial basal cell carcinomas treated with imiquimod. (17922128)
2007
24
5% 5-Fluorouracil cream for the treatment of small superficial Basal cell carcinoma: efficacy, tolerability, cosmetic outcome, and patient satisfaction. (17430377)
2007
25
Two-year interim results from a 5-year study evaluating clinical recurrence of superficial basal cell carcinoma after treatment with imiquimod 5% cream daily for 6 weeks. (17034468)
2006
26
Superficial basal cell carcinoma on face treated with 5% imiquimod cream. (17050935)
2006
27
Superficial basal cell carcinoma of the scalp mimicking seborrhoeic dermatitis. (16428215)
2006
28
Topical 5-aminolevulinic acid mediated photodynamic therapy of superficial basal cell carcinoma using two light fractions with a two-hour interval: long-term follow-up. (16955185)
2006
29
Dermoscopic differentiation of a superficial basal cell carcinoma and squamous cell carcinoma in situ. (16640692)
2006
30
Giant superficial basal cell carcinoma of the scrotum. (15908305)
2005
31
Recurrence rate of superficial basal cell carcinoma following successful treatment with imiquimod 5% cream: interim 2-year results from an ongoing 5-year follow-up study in Europe. (16172048)
2005
32
Nanoparticles as drug carrier system of 5-fluorouracil in local treatment of patients with superficial basal cell carcinoma. (17357210)
2005
33
Imiquimod induced regression of clinically diagnosed superficial basal cell carcinoma is associated with early infiltration by CD4 T cells and dendritic cells. (15550144)
2004
34
Possibility of treating basal cell carcinomas of nevoid basal cell carcinoma syndrome with superficial x-ray therapy. (14730239)
2004
35
Superficial radiotherapy for patients with basal cell carcinoma: recurrence rates, histologic subtypes, and expression of p53 and Bcl-2. (14669293)
2003
36
Evaluation of superficial basal cell carcinomas after treatment with imiquimod 5% cream or vehicle for apoptosis and lymphocyte phenotyping. (14725659)
2003
37
Evidence that superficial basal cell carcinoma is monoclonal from analysis of the Ptch1 gene locus. (12410703)
2002
38
Treatment of a large superficial basal cell carcinoma with 5% imiquimod: a case report and review of the literature. (11966794)
2002
39
Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: a double-blind, randomized, vehicle-controlled study. (12196749)
2002
40
Imiquimod 5% cream in the treatment of superficial basal cell carcinoma: results of a multicenter 6-week dose-response trial. (11312429)
2001
41
Ber-EP4-positive phenotype differentiates actinic keratosis from superficial basal cell carcinoma. (10816226)
2000
42
Guess what! Superficial basal cell carcinoma of the scrotum. (10408920)
1999
43
Differences in age, site distribution, and sex between nodular and superficial basal cell carcinoma indicate different types of tumors. (9620293)
1998
44
Photodynamic therapy of superficial basal cell carcinoma by instillation of aminolevulinic acid and irradiation with visible light. (9420532)
1997
45
Solar keratosis can be distinguished from superficial basal cell carcinoma by expression of bcl-2. (9335236)
1997
46
Pigmented basal cell carcinoma and superficial spreading malignant melanoma: an unusual combination. (6520255)
1984
47
Tumors of the skin. XI. Effect of occlusive dressing on the local administration of 5-fluorouracil to superficial basal cell carcinoma. (5774360)
1969
48
Superficial hidradenoma and basal-cell carcinoma. (4290147)
1966
49
SUPERFICIAL BASAL-CELL CARCINOMA. (14191739)
1964
50
Multiple Superficial Basal Cell Carcinoma. (19983548)
1924

Genetic Variations for Superficial Basal Cell Carcinoma

Expression for genes affiliated with Superficial Basal Cell Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Superficial Basal Cell Carcinoma

Search GEO for disease gene expression data for Superficial Basal Cell Carcinoma.

Pathways for genes affiliated with Superficial Basal Cell Carcinoma

Sources:
38NCBI BioSystems Database, 30KEGG, 4Cell Signaling Technology, 54Reactome, 52QIAGEN, 12EMD Millipore, 53R&D Systems
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Pathways related to Superficial Basal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5NOTCH1, DLL1
2
Hide members
9.1NOTCH1, DLL1, JAG1
39.1JAG1, DLL1, NOTCH1
4
Hide members
9.1JAG1, DLL1, NOTCH1
5
Hide members
9.1JAG1, DLL1, NOTCH1
6
Hide members
9.1NOTCH1, DLL1, JAG1
7
Hide members
9.1JAG1, DLL1, NOTCH1
8
Hide members
9.1NOTCH1, DLL1, JAG1
99.1JAG1, DLL1, NOTCH1
10
Hide members
8.7BCL2, IFNA1, TLR7
118.2BCL2, NOTCH1, DLL1, JAG1

Compounds for genes affiliated with Superficial Basal Cell Carcinoma

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 24HMDB
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Compounds related to Superficial Basal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1loxoribine45 2910.8IFNA1, TLR7
2resiquimod45 6010.8IFNA1, TLR7
3imiquimod45 29 60 1112.7IFNA1, TLR7
4polyinosinic-polycytidylic acid459.6IFNA1, TLR7
5ginsenoside459.4BCL2, MME
6poly(i-c)459.4TLR7, IFNA1
7dacarbazine45 1110.4BCL2, IFNA1
82-chlorodeoxyadenosine459.3IFNA1, BCL2
9fludarabine45 1110.1BCL2, IFNA1
10cytarabine45 50 1110.9IFNA1, MME, BCL2
11adriamycin458.9IFNA1, MME, BCL2
12mitoxantrone45 50 1110.8IFNA1, BCL2
13rapamycin458.6IFNA1, NOTCH1, BCL2
14actinomycin d458.6BCL2, MME, IFNA1
15doxorubicin45 50 1110.3BCL2, NOTCH1, MME, IFNA1
16dexamethasone45 50 29 1111.2IFNA1, MME, NOTCH1, BCL2
17vegf458.2IFNA1, MME, NOTCH1, BCL2
18retinoic acid45 249.1BCL2, NOTCH1, MME, IFNA1

GO Terms for genes affiliated with Superficial Basal Cell Carcinoma

Sources:
16Gene Ontology
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Biological processes related to Superficial Basal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1loop of Henle developmentGO:07207010.0JAG1, DLL1
2cell fate determinationGO:0017099.9DLL1, JAG1
3positive regulation of Notch signaling pathwayGO:0457479.9DLL1, JAG1
4compartment pattern specificationGO:0073869.8NOTCH1, DLL1
5distal tubule developmentGO:0720179.8NOTCH1, JAG1
6negative regulation of stem cell differentiationGO:20007379.8JAG1, NOTCH1
7left/right axis specificationGO:0709869.8NOTCH1, DLL1
8cardiac septum morphogenesisGO:0604119.8NOTCH1, JAG1
9pulmonary valve morphogenesisGO:0031849.7JAG1, NOTCH1
10Notch signaling involved in heart developmentGO:0613149.7NOTCH1, JAG1
11response to muramyl dipeptideGO:0324959.7NOTCH1, JAG1
12determination of left/right symmetryGO:0073689.5NOTCH1, DLL1
13heart loopingGO:0019479.5DLL1, NOTCH1
14neuronal stem cell maintenanceGO:0971509.4NOTCH1, DLL1, JAG1
15Notch receptor processingGO:0072209.4NOTCH1, DLL1, JAG1
16hemopoiesisGO:0300979.4DLL1, JAG1
17mesenchymal cell developmentGO:0140319.4NOTCH1, BCL2
18keratinocyte differentiationGO:0302169.3NOTCH1, JAG1
19Notch signaling pathwayGO:0072199.3JAG1, DLL1, NOTCH1
20negative regulation of anoikisGO:20008119.3NOTCH1, BCL2
21negative regulation of ossificationGO:0302799.2NOTCH1, BCL2
22hair follicle morphogenesisGO:0310699.2NOTCH1, BCL2
23humoral immune responseGO:0069599.1BCL2, NOTCH1
24axonogenesisGO:0074099.0BCL2, NOTCH1

Molecular functions related to Superficial Basal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Notch bindingGO:0051129.7DLL1, JAG1

Products for genes affiliated with Superficial Basal Cell Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Superficial Basal Cell Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet