MCID: SPR005
MIFTS: 34

Superficial Basal Cell Carcinoma malady

Categories: Cancer diseases

Aliases & Classifications for Superficial Basal Cell Carcinoma

Aliases & Descriptions for Superficial Basal Cell Carcinoma:

Name: Superficial Basal Cell Carcinoma 12 14 69
Multifocal Superficial Basal Cell Carcinoma 12 69
Superficial Multicentric Basal-Cell Carcinoma 12
Multicentric Basal Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4300
NCIt 47 C4108
SNOMED-CT 64 61098004
UMLS 69 C0334256

Summaries for Superficial Basal Cell Carcinoma

MalaCards based summary : Superficial Basal Cell Carcinoma, also known as multifocal superficial basal cell carcinoma, is related to basal cell carcinoma and squamous cell carcinoma. An important gene associated with Superficial Basal Cell Carcinoma is TLR7 (Toll Like Receptor 7), and among its related pathways/superpathways are IL-2 Pathway and Diseases associated with the TLR signaling cascade. The drugs Aminolevulinic acid and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include skin and t cells.

Related Diseases for Superficial Basal Cell Carcinoma

Diseases related to Superficial Basal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
id Related Disease Score Top Affiliating Genes
1 basal cell carcinoma 10.8
2 squamous cell carcinoma 10.1
3 keratosis 10.0
4 actinic keratosis 10.0
5 exophthalmos 9.9 TLR7 TLR8
6 melanoma 9.9
7 bowen's disease 9.9
8 epidermolytic hyperkeratosis 9.7
9 dermatitis 9.7
10 nodular basal cell carcinoma 9.7
11 psoriasis 9.7
12 signet ring basal cell carcinoma 9.1 BLK DSG2 PTCH1 TLR7 TLR8

Graphical network of the top 20 diseases related to Superficial Basal Cell Carcinoma:



Diseases related to Superficial Basal Cell Carcinoma

Symptoms & Phenotypes for Superficial Basal Cell Carcinoma

Drugs & Therapeutics for Superficial Basal Cell Carcinoma

Drugs for Superficial Basal Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 106-60-5 137
2
Imiquimod Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 99011-02-6 57469
3 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
4 Photosensitizing Agents Phase 4,Phase 3,Phase 2,Phase 1
5 Methyl 5-aminolevulinate Phase 4,Phase 3,Phase 1,Phase 2
6 interferons Phase 4,Phase 3,Phase 2,Phase 1
7 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2,Phase 1
8 Interferon Inducers Phase 4,Phase 3,Phase 2,Phase 1
9 Anesthetics Phase 3
10 Tea Nutraceutical Phase 2, Phase 3
11
Epinephrine Approved, Vet_approved 51-43-4 5816
12
Lidocaine Approved, Vet_approved 137-58-6 3676
13
Histamine Approved, Investigational 75614-87-8, 51-45-6 774
14
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
15 Epinephryl borate
16 Immunosuppressive Agents
17 Racepinephrine
18
Histamine Phosphate 51-74-1 65513
19 Mydriatics
20 Adrenergic Agents
21 Adrenergic Agonists
22 Sodium Channel Blockers
23 Adrenergic alpha-Agonists
24 Adrenergic beta-Agonists
25 Neurotransmitter Agents
26 Diuretics, Potassium Sparing
27 Peripheral Nervous System Agents
28 Anesthetics, Local
29 Vasoconstrictor Agents
30 Anti-Arrhythmia Agents
31 Anti-Asthmatic Agents
32 Respiratory System Agents
33 Autonomic Agents
34 Bronchodilator Agents
35 Central Nervous System Depressants

Interventional clinical trials:

(show all 41)
id Name Status NCT ID Phase
1 Superficial Basal Cell Carcinoma Treatment With Topical Photodynamic Therapy With Fractionated 5-aminolevulinic Acid 20% Versus Two Stage Methylaminolevulinate Unknown status NCT01491711 Phase 4
2 Safety and Efficacy Study of Imiquimod 5% Cream Applied 3x Per Week for 8 or 12 Weeks in Low Risk Nodular Basal Cell Carcinoma Completed NCT00204555 Phase 4
3 Open-label Study to Evaluate Clearance of Superficial Basal Cell Carcinoma After Use of Imiquimod 5% Cream Completed NCT00189306 Phase 3
4 Metvix PDT Versus Cryotherapy in Patients With Primary Superficial Basal Cell Carcinoma Completed NCT00469417 Phase 3
5 A Study to Evaluate Effectiveness of Imiquimod 5% Cream in Superficial Basal Cell Carcinoma Completed NCT00189241 Phase 3
6 Topical Green Tea Ointment in Treatment of Superficial Skin Cancer Completed NCT02029352 Phase 2, Phase 3
7 Topical Imiquimod Compared With Surgery in Treating Patients With Basal Cell Skin Cancer Completed NCT00066872 Phase 3
8 Aldara for the Treatment of Large and/or Multiple sBCC Completed NCT00189280 Phase 3
9 Radiotherapy or Imiquimod in Complex Lentigo Maligna Recruiting NCT02394132 Phase 3
10 Surgery Versus Combined Treatment With Curettage and Imiquimod for Nodular Basal Cell Carcinoma Recruiting NCT02242929 Phase 3
11 Dose-Ranging Clinical Trial of Topical Creams Containing API 31510 for the Treatment of Superficial Basal Cell Carcinoma Completed NCT00604890 Phase 2
12 PEP005 Gel - Evaluation of the Safety and Efficacy of Ingenol Mebutate Gel on a Superficial Basal Cell Carcinoma on the Trunk or Extremities Completed NCT01325688 Phase 2
13 Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Superficial Basal Cell Carcinoma Completed NCT00108134 Phase 2
14 To Determine the Maximum Tolerated Dose Level (MTD) of PEP005 Topical Gel in Patients With sBCC Completed NCT00432185 Phase 2
15 Photochemical Tissue Bonding Completed NCT00586040 Phase 2
16 Immunevasion of Human Papillomavirus (HPV) in Vulvar Intraepithelial Neoplasia 2/3 and Anogenital Warts and Efficiency and Mechanisms of Imiquimod Treatment Completed NCT00941811 Phase 2
17 Photodynamic Therapy in Treating Patients With Skin Cancer Completed NCT00002975 Phase 2
18 Superficial Basal Cell Cancer's Photodynamic Therapy: Comparing Three Photosensitises: HAL and BF-200 ALA Versus MAL Recruiting NCT02367547 Phase 1, Phase 2
19 Study Evaluating the Efficacy of Oral Vismodegib in Various Histologic Subtypes Recruiting NCT01700049 Phase 2
20 Neoadjuvant Vismodegib in Patients With Large and/or Recurrent Resectable Basal Cell Carcinoma Not yet recruiting NCT03035188 Phase 2
21 To Evaluate the Safety, Local Tolerability, PK and PD of LDE225 on Sporadic Superficial and Nodular Skin Basal Cell Carcinomas (sBCC) Terminated NCT01033019 Phase 2
22 Efficacy and Safety Trial of Topical Resiquimod Gel (0.06%) in Patients With Nodular Basal Cell Carcinoma Terminated NCT01808950 Phase 1, Phase 2
23 Photodynamic Therapy Using Methyl-5-Aminolevulinate Hydrochloride Cream in Determining Pain Threshold in Patients With Skin Cancer Completed NCT01292668 Phase 1
24 Topical Imiquimod 5% Cream for Treatment of Cutaneous Neurofibromas in Adults With Neurofibromatosis 1 Completed NCT00865644 Phase 1
25 Recurrence Rate and Esthetic Outcome After Excision of Basal Cell Carcinomas Excluded From Trial NCT00515970 Unknown status NCT00639652
26 Mohs Versus Traditional Surgery - Basal-Cell Carcinomas (BCC) Unknown status NCT00699829
27 In-vivo Optical Coherence Tomography Imaging in Dermatooncology Unknown status NCT01680562
28 Pulsed Dye Laser in Treating Superficial Basal Cell Carcinomas Completed NCT02125669
29 Cytodiagnosis of Basal Cell Carcinoma and Actinic Keratosis Using Papanicolaou and May-grunwald-giemsa Stained Tissue Smear Completed NCT00218868
30 Clinical Diagnosis of Basal Cell Carcinoma Subtype Completed NCT01370824
31 Debulking Effect of Curretage on Basal Cell Carcinomas - a Histological Assessment. Completed NCT00237107
32 Absorbable Suture Versus Tissue Glue to Repair Defects Following Mohs Surgery Completed NCT01298167
33 Laser Assisted Drug Delivery in the Treatment of Superficial Non Melanoma Skin Cancer: a Randomized Controlled Trial Recruiting NCT03012009
34 Randomized Pilot Study of Treatment for BCC Using the Multiplex 595/1064 nm Laser Recruiting NCT02270645
35 Immunologic Profile of Chronically Photodamaged Skin Recruiting NCT02889159
36 Molecular Mechanisms of Senescence Predisposing to Cancer : Exploratory Analysis on Healthy Tissues (SkinAge). Recruiting NCT02553954
37 New Versus Approved Methyl-aminolevulinate Photodynamic Therapy (MAL-PDT) Regime in Basal Cell Carcinoma (BCC) Active, not recruiting NCT01482104
38 Assessment of the Clinic-pathological Correlation of Basal Cell Carcinoma Active, not recruiting NCT02825511
39 Compassionate Use of Metvix® (Methyl Aminolevulinate) Photodynamic Therapy (PDT) in Subjects With Field Actinic Keratoses, Large/Multiple Superficial Basal Cell Carcinomas (BCCs), or Bowen's Disease No longer available NCT00535080
40 Curettage Versus Excision in Nodular and Superficial Basal Cell Carcinomas Suspended NCT00515970
41 Cure Rates of Superficial Basal Cell Carcinoma (BCC) EDC Terminated NCT00994240

Search NIH Clinical Center for Superficial Basal Cell Carcinoma

Genetic Tests for Superficial Basal Cell Carcinoma

Anatomical Context for Superficial Basal Cell Carcinoma

MalaCards organs/tissues related to Superficial Basal Cell Carcinoma:

39
Skin, T Cells

Publications for Superficial Basal Cell Carcinoma

Articles related to Superficial Basal Cell Carcinoma:

(show top 50) (show all 123)
id Title Authors Year
1
Standard step sectioning of skin biopsy specimens diagnosed as superficial basal cell carcinoma frequently yields deeper and more aggressive subtypes. ( 28088999 )
2017
2
Preoperative prediction of histopathologic outcome in basal cell carcinoma - flat surface and multiple small erosions predict superficial basal cell carcinoma in lighter skin types. ( 26921200 )
2016
3
Treatment of superficial basal cell carcinoma with ingenol mebutate gel, 0.05%. ( 27574458 )
2016
4
Accuracy of optical coherence tomography for the diagnosis of superficial basal cell carcinoma - a prospective, consecutive, cohort study of 168 cases. ( 27146027 )
2016
5
Ablative Fractional Laser-Assisted Topical Fluorouracil for the Treatment of Superficial Basal Cell Carcinoma and Squamous Cell Carcinoma In Situ: A Follow-Up Study. ( 27359199 )
2016
6
Superficial Basal Cell Carcinoma Treated with Two Cycles of Ingenol Mebutate Gel 0.015. ( 27904293 )
2016
7
Treatment failure in superficial basal cell carcinoma following treatment with photodynamic therapy: is this a result of underdiagnosis? ( 27256516 )
2016
8
Surgery Versus 5% Imiquimod for NodularA and Superficial Basal Cell Carcinoma: 5-Year Results of the SINSA Randomized Controlled Trial. ( 27932240 )
2016
9
Two-fold illumination in topical 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) for superficial basal cell carcinoma (sBCC): A retrospective case series and cohort study. ( 26774689 )
2016
10
Superficial Basal Cell Carcinoma on the Face is a Diagnostic Challenge. ( 27057051 )
2016
11
Three year follow-up results of photodynamic therapy versus imiquimod versus fluorouracil for treatment of superficial basal cell carcinoma: a single blind, non-inferiority, randomized controlled trial. ( 27113429 )
2016
12
The effect of topical diclofenac 3% and calcitriol 3A I1g/g on superficial basal cell carcinoma (sBCC) and nodular basal cell carcinoma (nBCC): A phase II, randomized controlled trial. ( 27067393 )
2016
13
Superficial basal cell carcinoma. ( 27914672 )
2016
14
Reflectance confocal microscopy and dermoscopy for in vivo, non-invasive skin imaging of superficial basal cell carcinoma. ( 27123056 )
2016
15
Treatment of choice in superficial basal cell carcinoma. ( 25776243 )
2015
16
Patient Perception of Imiquimod Treatment for Actinic Keratosis and Superficial Basal Cell Carcinoma in 202 Patients. ( 25925162 )
2015
17
Commentary on 'Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial'. ( 25581586 )
2015
18
Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial: a critical appraisal. ( 25581584 )
2015
19
Response to 'Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial: a critical appraisal'. ( 25581585 )
2015
20
The importance of superficial basal cell carcinoma in a retrospective study of 139 patients who underwent Mohs micrographic surgery in a Brazilian university hospital. ( 26602517 )
2015
21
Melanoma in situ or superficial basal cell carcinoma? ( 26158373 )
2015
22
The choice and measurement of fluence in photodynamic therapy for superficial basal cell carcinoma: reply from the authors. ( 26154079 )
2015
23
Tumor thickness and adnexal extension of superficial basal cell carcinoma (sBCC) as determinants of treatment failure for methylaminolevulinate (MAL)-photodynamic therapy (PDT), imiquimod, and 5-fluorouracil (FU). ( 25935596 )
2015
24
Subcutaneous Sarcoidal Granuloma Underlying Superficial Basal Cell Carcinoma. ( 26677309 )
2015
25
The choice and measurement of fluence in photodynamic therapy for superficial basal cell carcinoma. ( 26146762 )
2015
26
Pulsed dye laser treatment of superficial basal cell carcinoma. ( 25776237 )
2015
27
New I+-papillomavirus 4 isolate in a verruca vulgaris with multicentric superficial basal cell carcinoma. ( 25557421 )
2015
28
Treatment of superficial basal cell carcinoma and squamous cell carcinoma in situ on the trunk and extremities with ablative fractional laser-assisted delivery of topical fluorouracil. ( 25687314 )
2015
29
Cost-effectiveness of topical imiquimod and fluorouracil vs. photodynamic therapy for treatment of superficial basal-cell carcinoma. ( 24749843 )
2014
30
The role of the 595-nm pulsed dye laser in treating superficial basal cell carcinoma: outcome of a double-blind randomized placebo-controlled trial. ( 25040296 )
2014
31
Photodynamic therapy versus topical imiquimod for treatment of superficial basal cell carcinoma: a subgroup analysis within a non-inferiority randomised controlled trial. ( 25066012 )
2014
32
Discordant expression of desmoglein 2 and 3 at the mRNA and protein levels in nodular and superficial basal cell carcinoma revealed by immunohistochemistry and fluorescent in situ hybridization. ( 24934917 )
2014
33
Immunocryosurgery for Non-superficial Basal Cell Carcinoma: A Pro-spective, Open-label Phase III Study for Tumours a8oa882 cm in Diameter. ( 23722308 )
2014
34
A case of scrotal superficial basal cell carcinoma caused by chronic arsenic exposure. ( 24566581 )
2014
35
Surgical excision versus imiquimod 5% cream for nodular and superficial basal-cell carcinoma (SINS): a multicentre, non-inferiority, randomised controlled trial. ( 24332516 )
2014
36
Biallelic alterations of the large tumor suppressor 1 (LATS1) gene in infiltrative, but not superficial, basal cell carcinomas in a Japanese patient with nevoid basal cell carcinoma syndrome. ( 25119020 )
2014
37
Superficial basal cell carcinoma successfully treated with ingenol mebutate gel 0.05% ( 25052730 )
2014
38
Thickness of superficial basal cell carcinoma (sBCC) predicts imiquimod efficacy: a proposal for a thickness-based definition of sBCC. ( 23627639 )
2013
39
Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial. ( 23683751 )
2013
40
Applicability of dermoscopy for evaluation of patients' response to non-ablative therapies for the treatment of superficial basal cell carcinoma. ( 24283541 )
2013
41
Combined Carbon Dioxide Laser with Photodynamic Therapy for Nodular and Superficial Basal Cell Carcinoma: Almost Scarless Cure With Minimal Recurrence. ( 23407256 )
2013
42
Aesthetic evaluation after non-invasive treatment for superficial basal cell carcinoma. ( 22103716 )
2013
43
Dermal changes in superficial basal cell carcinoma, melanoma in situ and actinic keratosis and their implications. ( 24117926 )
2013
44
Spoke wheel-like structures in superficial basal cell carcinoma: a correlation between dermoscopy, histopathology, and reflective confocal microscopy. ( 24124839 )
2013
45
Light fractionation significantly improves the response of superficial basal cell carcinoma to aminolaevulinic acid photodynamic therapy: five-year follow-up of a randomized, prospective trial. ( 22964973 )
2012
46
Overall treatment success after treatment of primary superficial basal cell carcinoma: a systematic review and meta-analysis of randomized and nonrandomized trials. ( 22612571 )
2012
47
Chronicle of a pigmented superficial Basal cell carcinoma. ( 23259087 )
2012
48
Large superficial Basal cell carcinoma arising in the scalp. ( 22028585 )
2011
49
Effectiveness and satisfaction with imiquimod for the treatment of superficial basal cell carcinoma in daily dermatological practice. ( 21348896 )
2011
50
A comparison in real clinical practice of methyl aminolevulinate photodynamic therapy and surgery for small superficial basal cell carcinoma: 3-year recurrence rates and cosmetic outcomes. ( 20456551 )
2011

Variations for Superficial Basal Cell Carcinoma

Expression for Superficial Basal Cell Carcinoma

Search GEO for disease gene expression data for Superficial Basal Cell Carcinoma.

Pathways for Superficial Basal Cell Carcinoma

Pathways related to Superficial Basal Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.66 BLK TLR7 TLR8
2
Show member pathways
11.76 TLR7 TLR8
3
Show member pathways
11.75 BLK TLR7 TLR8
4
Show member pathways
11.67 TLR7 TLR8
5 11.65 TLR7 TLR8
6 11.53 TLR7 TLR8
7
Show member pathways
11.46 TLR7 TLR8
8
Show member pathways
11.35 TLR7 TLR8
9 11.29 BLK TLR7 TLR8
10
Show member pathways
11.27 TLR7 TLR8
11 11.09 TLR7 TLR8

GO Terms for Superficial Basal Cell Carcinoma

Cellular components related to Superficial Basal Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endosome membrane GO:0010008 8.96 TLR7 TLR8
2 endolysosome membrane GO:0036020 8.62 TLR7 TLR8

Biological processes related to Superficial Basal Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.65 BLK TLR7 TLR8
2 defense response to virus GO:0051607 9.51 TLR7 TLR8
3 cellular response to mechanical stimulus GO:0071260 9.49 TLR7 TLR8
4 regulation of protein phosphorylation GO:0001932 9.46 TLR7 TLR8
5 toll-like receptor signaling pathway GO:0002224 9.43 TLR7 TLR8
6 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.4 TLR7 TLR8
7 toll-like receptor 9 signaling pathway GO:0034162 9.37 TLR7 TLR8
8 microglial cell activation GO:0001774 9.32 TLR7 TLR8
9 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.26 TLR7 TLR8
10 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.16 TLR7 TLR8
11 positive regulation of interferon-beta biosynthetic process GO:0045359 8.96 TLR7 TLR8
12 positive regulation of interferon-alpha biosynthetic process GO:0045356 8.62 TLR7 TLR8

Molecular functions related to Superficial Basal Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.16 TLR7 TLR8
2 double-stranded RNA binding GO:0003725 8.96 TLR7 TLR8
3 single-stranded RNA binding GO:0003727 8.62 TLR7 TLR8

Sources for Superficial Basal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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