MCID: SPR005
MIFTS: 44

Superficial Basal Cell Carcinoma malady

Cancer diseases category
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Summaries for Superficial Basal Cell Carcinoma

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33MalaCards
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MalaCards: Superficial Basal Cell Carcinoma, also known as multifocal superficial basal cell carcinoma, is related to basal cell carcinoma and melanoma. An important gene associated with Superficial Basal Cell Carcinoma is DLL1 (delta-like 1 (Drosophila)), and among its related pathways are Presenilin action in Notch and Wnt signaling and Neural Crest Differentiation. The compounds ginsenoside and dacarbazine have been mentioned in the context of this disorder. Affiliated tissues include skin and t cells, and related mouse phenotypes are hearing/vestibular/ear and renal/urinary system.

Aliases & Classifications for Superficial Basal Cell Carcinoma

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8Disease Ontology, 62UMLS, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

superficial basal cell carcinoma 8 62
multifocal superficial basal cell carcinoma 8 62
superficial multicentric basal-cell carcinoma 8
multicentric basal cell carcinoma 8


External Ids:

Disease Ontology8 DOID:4300
SNOMED-CT58 61098004
NCIt40 C4108

Related Diseases for Superficial Basal Cell Carcinoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Superficial Basal Cell Carcinoma:



Diseases related to superficial basal cell carcinoma

Symptoms for Superficial Basal Cell Carcinoma

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Drugs & Therapeutics for Superficial Basal Cell Carcinoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Superficial Basal Cell Carcinoma

Search NIH Clinical Center for Superficial Basal Cell Carcinoma

Genetic Tests for Superficial Basal Cell Carcinoma

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Anatomical Context for Superficial Basal Cell Carcinoma

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33MalaCards
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MalaCards organs/tissues related to Superficial Basal Cell Carcinoma:

33
Skin, T cells

Animal Models for Superficial Basal Cell Carcinoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Superficial Basal Cell Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.3NOTCH1, DLL1, BCL2, JAG1
2MP:00053678.3JAG1, BCL2, DLL1, NOTCH1
3MP:00053818.2JAG1, BCL2, DLL1, NOTCH1
4MP:00053698.2NOTCH1, DLL1, BCL2, JAG1
5MP:00053798.1NOTCH1, DLL1, BCL2, JAG1
6MP:00053978.1NOTCH1, DLL1, BCL2, JAG1
7MP:00107718.0MME, JAG1, BCL2, NOTCH1
8MP:00053857.8JAG1, BCL2, DLL1, NOTCH1
9MP:00053767.7MME, JAG1, BCL2, DLL1, NOTCH1

Publications for Superficial Basal Cell Carcinoma

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52PubMed
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Articles related to Superficial Basal Cell Carcinoma:

(show top 50)    (show all 88)
idTitleAuthorsYear
1
Immunocryosurgery for Non-superficial Basal Cell Carcinoma: A Pro-spective, Open-label Phase III Study for Tumours a8oa882 cm in Diameter. (23722308)
2014
2
Aesthetic evaluation after non-invasive treatment for superficial basal cell carcinoma. (22103716)
2013
3
Dermal changes in superficial basal cell carcinoma, melanoma in situ and actinic keratosis and their implications. (24117926)
2013
4
Spoke wheel-like structures in superficial basal cell carcinoma: a correlation between dermoscopy, histopathology, and reflective confocal microscopy. (24124839)
2013
5
Combined Carbon Dioxide Laser with Photodynamic Therapy for Nodular and Superficial Basal Cell Carcinoma: Almost Scarless Cure With Minimal Recurrence. (23407256)
2013
6
Applicability of dermoscopy for evaluation of patients' response to non-ablative therapies for the treatment of superficial basal cell carcinoma. (24283541)
2013
7
Light fractionation significantly improves the response of superficial basal cell carcinoma to aminolaevulinic acid photodynamic therapy: five-year follow-up of a randomized, prospective trial. (22964973)
2012
8
Chronicle of a pigmented superficial Basal cell carcinoma. (23259087)
2012
9
Effectiveness and satisfaction with imiquimod for the treatment of superficial basal cell carcinoma in daily dermatological practice. (21348896)
2011
10
Large superficial Basal cell carcinoma arising in the scalp. (22028585)
2011
11
A comparison in real clinical practice of methyl aminolevulinate photodynamic therapy and surgery for small superficial basal cell carcinoma: 3-year recurrence rates and cosmetic outcomes. (20456551)
2011
12
PEP005 (ingenol mebutate) gel for the topical treatment of superficial basal cell carcinoma: results of a randomized phase IIa trial. (20546215)
2010
13
Large superficial basal cell carcinoma arising from moxa cautery. (19451052)
2009
14
Superficial basal cell carcinoma treated with imiquimod 5% topical cream for a 4-week period: a case series. (19646136)
2009
15
Vitiligo-like depigmentation induced by imiquimod treatment of superficial basal cell carcinoma. (19659986)
2009
16
Management of superficial basal cell carcinoma: focus on imiquimod. (21436969)
2009
17
A clinical study comparing methyl aminolevulinate photodynamic therapy and surgery in small superficial basal cell carcinoma (8-20 mm), with a 12-month follow-up. (18624836)
2008
18
Microscopic distribution of protoporphyrin (PpIX) fluorescence in superficial basal cell carcinoma during light-fractionated aminolaevulinic acid photodynamic therapy. (19002337)
2008
19
Dermoscopic patterns of superficial basal cell carcinoma. (18986346)
2008
20
Giant superficial basal cell carcinoma treated with cryosurgery. (18657160)
2008
21
Primary superficial basal cell carcinoma of the nipple. (17684426)
2007
22
Induction of the members of Notch pathway in superficial basal cell carcinomas treated with imiquimod. (17922128)
2007
23
CD-10 immunostaining differentiates superficial basal cell carcinoma from cutaneous squamous cell carcinoma. (18032951)
2007
24
5% 5-Fluorouracil cream for the treatment of small superficial Basal cell carcinoma: efficacy, tolerability, cosmetic outcome, and patient satisfaction. (17430377)
2007
25
Radial streaking: unusual dermoscopic pattern in pigmented superficial basal cell carcinoma. (17894724)
2007
26
Two-year interim results from a 5-year study evaluating clinical recurrence of superficial basal cell carcinoma after treatment with imiquimod 5% cream daily for 6 weeks. (17034468)
2006
27
Superficial basal cell carcinoma on face treated with 5% imiquimod cream. (17050935)
2006
28
Superficial basal cell carcinoma of the scalp mimicking seborrhoeic dermatitis. (16428215)
2006
29
Management of primary superficial basal cell carcinoma. (16751865)
2006
30
Photodynamic therapy for superficial basal cell carcinoma and Bowen's disease. (16436340)
2006
31
Clinical and histopathologic findings of superficial basal cell carcinoma: A comparison with other basal cell carcinoma subtypes. (16970272)
2006
32
Dermoscopic monitoring of tazarotene treatment of superficial basal cell carcinoma. (15762218)
2005
33
Giant superficial basal cell carcinoma of the scrotum. (15908305)
2005
34
595 nm pulsed dye laser for the treatment of superficial basal cell carcinoma. (16328096)
2005
35
Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from a randomized vehicle-controlled phase III study in Europe. (15888150)
2005
36
A case of penile superficial basal cell carcinoma involving the inner surface of foreskin. (16303075)
2005
37
5% imiquimod cream for the treatment of large superficial basal cell carcinoma. (15492202)
2004
38
Imiquimod induced regression of clinically diagnosed superficial basal cell carcinoma is associated with early infiltration by CD4 T cells and dendritic cells. (15550144)
2004
39
Evidence that superficial basal cell carcinoma is monoclonal from analysis of the Ptch1 gene locus. (12410703)
2002
40
Treatment of a large superficial basal cell carcinoma with 5% imiquimod: a case report and review of the literature. (11966794)
2002
41
Imiquimod 5% cream in the treatment of superficial basal cell carcinoma: results of a multicenter 6-week dose-response trial. (11312429)
2001
42
Ber-EP4-positive phenotype differentiates actinic keratosis from superficial basal cell carcinoma. (10816226)
2000
43
Guess what! Superficial basal cell carcinoma of the scrotum. (10408920)
1999
44
Therapeutic options for superficial basal cell carcinoma: the role of radiation therapy. (9645651)
1998
45
Differences in age, site distribution, and sex between nodular and superficial basal cell carcinoma indicate different types of tumors. (9620293)
1998
46
Photodynamic therapy of superficial basal cell carcinoma by instillation of aminolevulinic acid and irradiation with visible light. (9420532)
1997
47
Tumors of the skin. XI. Effect of occlusive dressing on the local administration of 5-fluorouracil to superficial basal cell carcinoma. (5774360)
1969
48
SUPERFICIAL BASAL-CELL CARCINOMA. (14191739)
1964
49
The histological findings in normal skin and multiple superficial basal cell carcinoma treated with an ointment containing demecolcine. (14406310)
1959
50
Superficial Basal-cell Carcinoma. (19992640)
1943

Variations for Superficial Basal Cell Carcinoma

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Expression for genes affiliated with Superficial Basal Cell Carcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Superficial Basal Cell Carcinoma

Search GEO for disease gene expression data for Superficial Basal Cell Carcinoma.

Pathways for genes affiliated with Superficial Basal Cell Carcinoma

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50PathCards, 38NCBI BioSystems Database, 30KEGG, 57SinoBiological, 5Cell Signaling Technology, 53QIAGEN, 55Reactome, 60Thomson Reuters, 54R&D Systems
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Pathways related to Superficial Basal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4NOTCH1, DLL1
29.4NOTCH1, DLL1
3
Show member pathways
9.3NOTCH1, JAG1
49.3JAG1, NOTCH1
59.0NOTCH1, BCL2
6
Show member pathways
8.9JAG1, DLL1, NOTCH1
7
Show member pathways
Notch signaling pathway38
8.9JAG1, DLL1, NOTCH1
88.9NOTCH1, DLL1, JAG1
9
Show member pathways
8.9NOTCH1, DLL1, JAG1
10
Show member pathways
Delta-Notch Signaling Pathway38
Notch Signaling Pathway38
8.9NOTCH1, DLL1, JAG1
11
Show member pathways
Development Notch Signaling Pathway60
Transcription Sin3 and NuRD in transcription regulation60
8.9NOTCH1, DLL1, JAG1
12
Show member pathways
8.6NOTCH1, DLL1, BCL2
138.1NOTCH1, DLL1, BCL2, JAG1

Compounds for genes affiliated with Superficial Basal Cell Carcinoma

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45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 24HMDB, 29IUPHAR
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Compounds related to Superficial Basal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1ginsenoside459.6MME, BCL2
2dacarbazine45 1110.5BCL2, IFNA1
32-chlorodeoxyadenosine459.5BCL2, IFNA1
4mitoxantrone45 51 1111.4BCL2, IFNA1
5fludarabine45 51 1111.4IFNA1, BCL2
6rituximab45 51 1111.4BCL2, IFNA1
7vinblastine45 51 1111.4IFNA1, BCL2
8thymidylate459.4BCL2, IFNA1
9vincristine45 51 1111.3BCL2, IFNA1
10camptothecin45 61 1111.3BCL2, IFNA1
11quercetin45 61 24 1112.3BCL2, MME
12docetaxel45 51 61 1112.2BCL2, IFNA1
13cyclophosphamide45 51 1111.1BCL2, IFNA1
14nitric oxide45 24 1111.1MME, JAG1, NOTCH1
15cytarabine45 51 1111.1BCL2, IFNA1, MME
16adriamycin459.0MME, IFNA1, BCL2
17actinomycin d459.0BCL2, IFNA1, MME
18cycloheximide459.0MME, IFNA1, BCL2
19rapamycin458.8IFNA1, BCL2, NOTCH1
20imatinib45 51 1110.8BCL2, IFNA1
21phosphatidylinositol458.8NOTCH1, BCL2, MME
22oxygen45 249.6MME, BCL2, NOTCH1
23estrogen458.5NOTCH1, BCL2, MME
24doxorubicin45 51 1110.4NOTCH1, BCL2, IFNA1, MME
25dexamethasone45 51 29 1111.4NOTCH1, BCL2, IFNA1, MME
26vegf458.4MME, IFNA1, BCL2, NOTCH1
27retinoic acid45 249.4NOTCH1, BCL2, IFNA1, MME
28serine458.3NOTCH1, BCL2, IFNA1, MME

GO Terms for genes affiliated with Superficial Basal Cell Carcinoma

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16Gene Ontology
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Biological processes related to Superficial Basal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1loop of Henle developmentGO:0720709.9JAG1, DLL1
2cell fate determinationGO:0017099.8DLL1, JAG1
3compartment pattern specificationGO:0073869.8NOTCH1, DLL1
4positive regulation of Notch signaling pathwayGO:0457479.7JAG1, DLL1
5left/right axis specificationGO:0709869.7NOTCH1, DLL1
6distal tubule developmentGO:0720179.7NOTCH1, JAG1
7negative regulation of stem cell differentiationGO:20007379.7JAG1, NOTCH1
8cardiac septum morphogenesisGO:0604119.7NOTCH1, JAG1
9pulmonary valve morphogenesisGO:0031849.6NOTCH1, JAG1
10Notch signaling involved in heart developmentGO:0613149.6NOTCH1, JAG1
11response to muramyl dipeptideGO:0324959.6JAG1, NOTCH1
12determination of left/right symmetryGO:0073689.6NOTCH1, DLL1
13heart loopingGO:0019479.6DLL1, NOTCH1
14hemopoiesisGO:0300979.4JAG1, DLL1
15keratinocyte differentiationGO:0302169.4NOTCH1, JAG1
16mesenchymal cell developmentGO:0140319.4BCL2, NOTCH1
17neuronal stem cell maintenanceGO:0971509.3NOTCH1, DLL1, JAG1
18Notch receptor processingGO:0072209.3NOTCH1, DLL1, JAG1
19negative regulation of ossificationGO:0302799.3NOTCH1, BCL2
20negative regulation of anoikisGO:20008119.3NOTCH1, BCL2
21Notch signaling pathwayGO:0072199.2JAG1, DLL1, NOTCH1
22hair follicle morphogenesisGO:0310699.2NOTCH1, BCL2
23humoral immune responseGO:0069599.0NOTCH1, BCL2
24positive regulation of transcription from RNA polymerase II promoterGO:0459448.9NOTCH1, DLL1, JAG1
25axonogenesisGO:0074098.7NOTCH1, BCL2

Molecular functions related to Superficial Basal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Notch bindingGO:0051129.2DLL1, JAG1
2calcium ion bindingGO:0055098.9NOTCH1, DLL1, JAG1

Products for genes affiliated with Superficial Basal Cell Carcinoma

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Sources for Superficial Basal Cell Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet