MCID: SPR066
MIFTS: 38

Superficial Siderosis malady

Neuronal diseases, Rare diseases categories

Summaries for Superficial Siderosis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Superficial hemosiderosis of the central nervous system is a disease of the brain resulting from chronic... more...

MalaCards: Superficial Siderosis is related to siderosis and superficial siderosis of the central nervous system. An important gene associated with Superficial Siderosis is FTH1 (ferritin, heavy polypeptide 1), and among its related pathways are Iron metabolism in placenta and Metabolism of porphyrins. The compounds ferrous ammonium sulfate and iron dextran have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Superficial Siderosis

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Sources:
50Orphanet, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

50
superficial siderosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

superficial siderosis 50


External Ids:

ICD10 via Orphanet27 I69.0

Related Diseases for Superficial Siderosis

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Superficial Siderosis:



Diseases related to superficial siderosis

Symptoms for Superficial Siderosis

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Drugs & Therapeutics for Superficial Siderosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Superficial Siderosis

Search CenterWatch for Superficial Siderosis

Genetic Tests for Superficial Siderosis

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Anatomical Context for Superficial Siderosis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Superficial Siderosis:

34
Brain, Spinal cord, Bone

Animal Models for Superficial Siderosis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Superficial Siderosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0HMOX1, FTH1, TTR, TF

Publications for Superficial Siderosis

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Sources:
53PubMed
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Articles related to Superficial Siderosis:

(show top 50)    (show all 218)
idTitleAuthorsYear
1
Neuropathology of cortical superficial siderosis and cerebral amyloid angiopathy: new insights, new questions. (24281141)
2013
2
Teaching neuroImages: MRI changes in superficial siderosis. (22547776)
2012
3
Progression and management of superficial siderosis. (22342237)
2012
4
T2*-weighted MRI findings of superficial siderosis. (22821124)
2012
5
Superficial siderosis associated with multiple dural tears opening into a spinal epidural fluid collection. (21748941)
2011
6
A patient with superficial siderosis, intraspinal cyst, low-pressure headache and low-lying cord. (22368982)
2011
7
Superficial siderosis in cerebral amyloid angiopathy. (21654928)
2011
8
Superficial siderosis of the central nervous system: phenotype and implications for audiology and otology. (21730883)
2011
9
Superficial siderosis of the CNS. (21700976)
2011
10
Cochlear implantation in a patient with superficial siderosis: an update. (20015783)
2010
11
Superficial siderosis mimicking amyotrophic lateral sclerosis. (20215988)
2010
12
Superficial siderosis of the central nervous system manifested with seizures. (20006512)
2010
13
Intraventricular cavernous malformation with superficial siderosis. (20457968)
2010
14
Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy. (20975060)
2010
15
Iron localization in superficial siderosis of the central nervous system. (18694445)
2009
16
Cochlear implant patients with superficial siderosis. (19594083)
2009
17
Superficial siderosis: sealing the defect. (19221303)
2009
18
Cognitive impairment in superficial siderosis of the central nervous system: a case report. (18937022)
2009
19
Superficial siderosis revealed by isolated cognitive impairment. (19196635)
2009
20
Systemic sclerosis and superficial siderosis of the central nervous system: casuality or causality? (18193230)
2008
21
Cerebellar atrophy revealing superficial siderosis. (18795601)
2008
22
The pathology of superficial siderosis of the central nervous system. (18696091)
2008
23
Superficial siderosis of the central nervous system and its cochleovestibular consequences. (19137643)
2008
24
Superficial siderosis: associations and therapeutic implications. (17420310)
2007
25
Superficial siderosis due to papillary glioneuronal tumor. (17049863)
2006
26
Cognitive and social impairments in patients with superficial siderosis. (15788543)
2005
27
Central nervous system superficial siderosis following spinal surgery. (15739535)
2005
28
Continuation of oral anticoagulation despite superficial siderosis. (14678820)
2003
29
MRI findings in a case of a superficial siderosis associated with an ependymoma. (12297737)
2002
30
Superficial siderosis from spinal teratoma. (12443590)
2002
31
Superficial siderosis 20 years after brain tumour. (12849430)
2002
32
Neuro-otologic findings in a case of superficial siderosis with bilateral hearing impairment. (11771051)
2001
33
Superficial siderosis of the central nervous system in a patient with neurofibromatosis type I. (10686476)
2000
34
Superficial siderosis of the central nervous system. A case report on examination by ECoG and DPOAE. (10965263)
2000
35
Evidence for preganglionic pupillary involvement in superficial siderosis. (10496281)
1999
36
Elevated CSF lactoferrin in superficial siderosis of the central nervous system. (10552243)
1999
37
Superficial siderosis of the central nervous system and anticoagulant therapy: a case report. (10551912)
1999
38
Secondary superficial siderosis of the central nervous system in a patient presenting with sensorineural hearing loss. (9638673)
1998
39
Neuroradiology case of the day. Myxopapillary ependymoma of the conus medullaris or filum terminale resulting in superficial siderosis and dissemination of tumor along CSF pathways. (9599402)
1998
40
Morphological and functional study of a case of superficial siderosis of the central nervous system. (9239533)
1997
41
Focal dystonia secondary to superficial siderosis. (8813232)
1996
42
Superficial siderosis of the brain: roles for cerebrospinal fluid circulation, iron and the hydroxyl radical. (8910872)
1996
43
Superficial siderosis--a cause of audiovestibular failure. (8816109)
1996
44
Superficial siderosis of the central nervous system: a neglected cause of sensorineural hearing loss. (1528605)
1992
45
Superficial siderosis of the brain following unexplained subarachnoid hemorrhage: MRI diagnosis and clinical significance. (1407522)
1992
46
Superficial siderosis of the central nervous system. A 37-year follow-up of a case and review of the literature. (1832307)
1991
47
Superficial siderosis of the central nervous system. (2926762)
1989
48
High-field MR imaging of superficial siderosis of the central nervous system. (4031180)
1985
49
Superficial siderosis of the central nervous system. (5100703)
1971
50
Superficial siderosis of the central nervous system. A histological, histochemical and chemical study. (5567573)
1971

Variations for Superficial Siderosis

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Expression for genes affiliated with Superficial Siderosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Superficial Siderosis

Search GEO for disease gene expression data for Superficial Siderosis.

Pathways for genes affiliated with Superficial Siderosis

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG
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Pathways related to Superficial Siderosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3FTH1, TF
2
Show member pathways
tetrapyrrole biosynthesis39
heme degradation39
Heme Biosynthesis39
heme biosynthesis39
heme biosynthesis from uroporphyrinogen-III I39
9.1FTH1, HMOX1
39.0HMOX1, TF
49.0HMOX1, TF
5
Show member pathways
8.5HMOX1, FTH1, TF
68.5HMOX1, FTH1, TF
7
Show member pathways
8.5HMOX1, FTH1, TF

Compounds for genes affiliated with Superficial Siderosis

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 25HMDB, 62Tocris Bioscience, 52PharmGKB
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Compounds related to Superficial Siderosis according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1ferrous ammonium sulfate469.8TF, FTH1
2iron dextran46 1210.8TF, FTH1
3apotransferrin469.8TF, FTH1
4tbps46 3010.7TF, TTR
5fe3+469.7TF, FTH1
6tocopherol469.7TTR, TF
7fe2+469.7FTH1, TF
8glutaraldehyde469.7TTR, TF
9vitamin b12469.7TF, TTR
10betacarotene469.7TTR, TF
11adenine46 25 1211.6TF, TTR
12carbohydrates469.6TTR, TF
13thyroxine46 2510.6TTR, TF
14copper46 2510.6TF, FTH1
15folate469.5TTR, TF
16salicylic acid46 3010.5HMOX1, TTR
17zinc protoporphyrin469.4HMOX1, TF
18fenton469.4HMOX1, TF
19protoporphyrin ix46 25 1211.4HMOX1, TF
20resveratrol46 62 25 1212.4HMOX1, TTR
218-isoprostane469.4HMOX1, TF
22vitamin a46 25 1211.4TTR, TF
23phenobarbital46 30 52 1212.4TF, HMOX1
24polyethylene glycol469.4HMOX1, TF
25sodium nitroprusside469.3HMOX1, TF
26carbon469.3HMOX1, FTH1
27nifedipine46 30 52 1212.3TF, HMOX1
28citrate469.3HMOX1, TF
29agar469.2TTR, TF
30prostacyclin469.2TF, HMOX1
31heme30 25 1211.1HMOX1, TF
32aspirin46 52 30 2512.1TTR, HMOX1
33epinephrine46 25 1211.0TTR, TF
34n acetylcysteine469.0HMOX1, TF
35deferoxamine46 129.9TF, FTH1, HMOX1
36alpha tocopherol468.9HMOX1, TTR, TF
37norepinephrine46 25 1210.9TF, TTR, HMOX1
38cyclosporin a46 30 6210.9TF, TTR, HMOX1
39lactate468.9TF, TTR, HMOX1
40alanine468.8HMOX1, TTR, TF
41estrogen468.8TF, TTR, HMOX1
42ascorbic acid46 259.4HMOX1, FTH1, TTR, TF
43iron46 259.4HMOX1, FTH1, TTR, TF

GO Terms for genes affiliated with Superficial Siderosis

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17Gene Ontology
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Cellular components related to Superficial Siderosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5HMOX1, TTR, TF

Biological processes related to Superficial Siderosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane transportGO:0550858.5HMOX1, FTH1, TF
2cellular iron ion homeostasisGO:0068798.2HMOX1, FTH1, TF

Molecular functions related to Superficial Siderosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferric iron bindingGO:0081999.3FTH1, TF

Products for genes affiliated with Superficial Siderosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Superficial Siderosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet