MCID: SPR066
MIFTS: 33

Superficial Siderosis malady

Neuronal category

Summaries for Superficial Siderosis

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Superficial hemosiderosis of the central nervous system is a disease of the brain resulting from chronic... more...

MalaCards: Superficial Siderosis is related to siderosis and alzheimer's disease. An important gene associated with Superficial Siderosis is FTH1 (ferritin, heavy polypeptide 1), and among its related pathways are Iron metabolism in placenta and HIF-1 signaling pathway. The compounds ferrous ammonium sulfate and apotransferrin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and brain, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Superficial Siderosis

Sources:
49Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
superficial siderosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

superficial siderosis 49


External Ids:

ICD10 via Orphanet26 I69.0

Related Diseases for Superficial Siderosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Superficial Siderosis:



Diseases related to superficial siderosis

Clinical Features for Superficial Siderosis

Drugs & Therapeutics for Superficial Siderosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Superficial Siderosis

Drug clinical trials:

Search ClinicalTrials for Superficial Siderosis

Search NIH Clinical Center for Superficial Siderosis

Search CenterWatch for Superficial Siderosis

Genetic Tests for Superficial Siderosis

Anatomical Context for Superficial Siderosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Superficial Siderosis:

33
Spinal cord, Brain

Animal Models for Superficial Siderosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Superficial Siderosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0HMOX1, TTR, FTH1, TF

Publications for Superficial Siderosis

Sources:
51PubMed
See all sources

Articles related to Superficial Siderosis:

(show top 50)    (show all 225)
idTitleAuthorsYear
1
Neuropathology of cortical superficial siderosis and cerebral amyloid angiopathy: new insights, new questions. (24281141)
2013
2
Superficial siderosis is a warning sign for future intracranial hemorrhage. (22820723)
2013
3
Superficial siderosis and sudden sensorineural hearing loss: a case report and review of the literature. (23762708)
2013
4
Superficial siderosis of central nervous system in patients with brachial plexus injury. (23456443)
2013
5
Agranulocytosis with deferiprone treatment of superficial siderosis. (23925681)
2013
6
Auditory profile in superficial siderosis of the central nervous system: a prospective study. (23670174)
2013
7
Superficial siderosis of the central nervous system due to chronic hemorrhage from a giant invasive prolactinoma. (23664407)
2013
8
Superficial siderosis due to dural defect with thoracic spinal cord herniation. (21868040)
2012
9
Update on a patient with superficial siderosis on deferiprone. (22576890)
2012
10
Superficial siderosis of the CNS. (21700976)
2011
11
Idiopathic superficial siderosis. (21987551)
2011
12
Deferiprone reduces hemosiderin deposits in the brain of a patient with superficial siderosis. (21051507)
2011
13
Superficial cortical siderosis. (21748942)
2011
14
Superficial siderosis: a case report. (21968884)
2011
15
Superficial siderosis of the central nervous system due to bilateral jugular vein thrombosis. (20937957)
2010
16
Neuroimaging in superficial siderosis: an in-depth look. (19729538)
2010
17
Successful cochlear implantation in a patient with superficial siderosis of the central nervous system. (19887990)
2010
18
Cochlear implant patients with superficial siderosis. (19594083)
2009
19
Superficial siderosis revealed by isolated cognitive impairment. (19196635)
2009
20
Superficial siderosis of the central nervous system - treatment with steroids? (19753681)
2009
21
Teaching neuroimages: superficial siderosis. (19237692)
2009
22
Malpositioned spinal instrument as a possible cause of superficial siderosis. (19333243)
2009
23
The pathology of superficial siderosis of the central nervous system. (18696091)
2008
24
Hyperphosphorylation of tau protein in superficial CNS siderosis. (18617192)
2008
25
Association of superficial siderosis of the central nervous system and low pressure headache. (18344051)
2008
26
Cerebral hemiatrophy with superficial siderosis and PLEDs due to a germ cell tumor of the basal ganglia. (16879304)
2006
27
Unusual neuroimaging in superficial siderosis. (16087926)
2005
28
Superficial siderosis of the central nervous system following cervical nerve root avulsion: the importance of early diagnosis and surgery. (15662570)
2005
29
Superficial siderosis: a potentially important cause of genetic as well as non-genetic deafness. (15368490)
2004
30
MRI findings in a case of a superficial siderosis associated with an ependymoma. (12297737)
2002
31
Superficial siderosis associated with anterior horn cell dysfunction. (11796786)
2002
32
Polyradiculopathy in the course of superficial siderosis of the CNS. (12013591)
2001
33
Surgical resection of a cerebral arteriovenous malformation for treatment of superficial siderosis: case report. (10940422)
2000
34
Superficial CNS siderosis and spinal pilocytic astrocytoma. (10932289)
2000
35
Superficial siderosis of the CNS: a late complication of cerebellar tumors. (10563659)
1999
36
Secondary superficial siderosis of the central nervous system in a patient presenting with sensorineural hearing loss. (9638673)
1998
37
Neuroradiology case of the day. Myxopapillary ependymoma of the conus medullaris or filum terminale resulting in superficial siderosis and dissemination of tumor along CSF pathways. (9599402)
1998
38
Surgical treatment of superficial siderosis associated with a spinal arteriovenous malformation. Case report. (9833832)
1998
39
Morphological and functional study of a case of superficial siderosis of the central nervous system. (9239533)
1997
40
Superficial siderosis of the central nervous system. Its MRI manifestations. (9215469)
1997
41
Presence of superficial siderosis assists in the diagnosis of myxopapillary ependymoma. (8633473)
1996
42
Superficial siderosis of the central nervous system. (15374298)
1994
43
Posterior fossa surgery: an unusual cause of superficial siderosis. (8455772)
1993
44
Superficial siderosis of the brain following unexplained subarachnoid hemorrhage: MRI diagnosis and clinical significance. (1407522)
1992
45
Superficial siderosis of the central nervous system: report of three cases and review of the literature. (1402994)
1992
46
Superficial siderosis of the central nervous system. (2926762)
1989
47
Brain hemosiderin and superficial siderosis of the central nervous system. (3367157)
1988
48
High-field spin-echo MR imaging of superficial and subependymal siderosis secondary to neonatal intraventricular hemorrhage. (3627414)
1987
49
High-field MR imaging of superficial siderosis of the central nervous system. (4031180)
1985
50
Superficial siderosis of the central nervous system. A report on nine cases with autopsy. (5784099)
1969

Genetic Variations for Superficial Siderosis

Expression for genes affiliated with Superficial Siderosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Superficial Siderosis

Search GEO for disease gene expression data for Superficial Siderosis.

Pathways for genes affiliated with Superficial Siderosis

Sources:
38NCBI BioSystems Database, 30KEGG, 54Reactome
See all sources

Pathways related to Superficial Siderosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3TF, FTH1
29.0HMOX1, TF
39.0HMOX1, TF
4
Hide members
8.5HMOX1, FTH1, TF
58.5HMOX1, FTH1, TF
6
Hide members
8.5HMOX1, FTH1, TF

Compounds for genes affiliated with Superficial Siderosis

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 50PharmGKB
See all sources

Compounds related to Superficial Siderosis according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1ferrous ammonium sulfate459.7FTH1, TF
2apotransferrin459.7FTH1, TF
3iron dextran45 1110.7FTH1, TF
4tbps45 2910.7TF, TTR
5fe3+459.7TF, FTH1
6tocopherol459.7TTR, TF
7fe2+459.7TF, FTH1
8glutaraldehyde459.7TF, TTR
9vitamin b12459.6TTR, TF
10betacarotene459.6TTR, TF
11zinc protoporphyrin459.4TF, HMOX1
12salicylic acid45 2910.4TTR, HMOX1
13fenton459.4HMOX1, TF
14protoporphyrin ix45 11 2411.4HMOX1, TF
15adenine45 11 2411.4TF, TTR
168-isoprostane459.4HMOX1, TF
17resveratrol45 60 11 2412.3HMOX1, TTR
18carbohydrates459.3TTR, TF
19phenobarbital45 29 1111.3HMOX1, TF
20polyethylene glycol459.3HMOX1, TF
21sodium nitroprusside459.3TF, HMOX1
22thyroxine45 2410.2TTR, TF
23nifedipine45 50 29 1112.2HMOX1, TF
24citrate459.1HMOX1, TF
25carbon459.1HMOX1, FTH1
26copper45 2410.0FTH1, TF
27deferoxamine45 119.9HMOX1, FTH1, TF
28alpha tocopherol458.9TF, TTR, HMOX1
29norepinephrine45 11 2410.9TF, TTR, HMOX1
30cyclosporin a45 29 6010.8HMOX1, TTR, TF
31lactate458.8TF, TTR, HMOX1
32alanine458.7HMOX1, TTR, TF
33estrogen458.7TF, TTR, HMOX1
34ascorbic acid45 249.4HMOX1, TTR, FTH1, TF
35iron45 249.4TF, FTH1, TTR, HMOX1

GO Terms for genes affiliated with Superficial Siderosis

Sources:
16Gene Ontology
See all sources

Biological processes related to Superficial Siderosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane transportGO:0550858.5HMOX1, FTH1, TF
2cellular iron ion homeostasisGO:0068798.2HMOX1, FTH1, TF

Molecular functions related to Superficial Siderosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferric iron bindingGO:0081999.3FTH1, TF

Products for genes affiliated with Superficial Siderosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Superficial Siderosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet