MCID: SPR066
MIFTS: 33

Superficial Siderosis malady

Neuronal diseases, Rare diseases categories

Summaries for Superficial Siderosis

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Wikipedia:63 Superficial hemosiderosis of the central nervous system is a disease of the brain resulting from chronic... more...

MalaCards based summary: Superficial Siderosis is related to siderosis and superficial siderosis of the central nervous system. An important gene associated with Superficial Siderosis is FTH1 (ferritin, heavy polypeptide 1), and among its related pathways are Iron metabolism in placenta and Metabolism of porphyrins. The compounds ferrous ammonium sulfate and iron dextran have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and spinal cord, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Superficial Siderosis

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Sources:
47Orphanet, 26ICD10 via Orphanet
See all sources

Superficial Siderosis, Aliases & Descriptions:

Name: Superficial Siderosis 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
superficial siderosis:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Orphanet47 247245
ICD10 via Orphanet26 I69.0

Related Diseases for Superficial Siderosis

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Graphical network of the top 20 diseases related to Superficial Siderosis:



Diseases related to superficial siderosis

Symptoms for Superficial Siderosis

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Drugs & Therapeutics for Superficial Siderosis

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Drug clinical trials:

Search ClinicalTrials for Superficial Siderosis

Search NIH Clinical Center for Superficial Siderosis

Genetic Tests for Superficial Siderosis

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Anatomical Context for Superficial Siderosis

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MalaCards organs/tissues related to Superficial Siderosis:

31
Brain, Bone, Spinal cord, Bone marrow

Animal Models for Superficial Siderosis or affiliated genes

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MGI Mouse Phenotypes related to Superficial Siderosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0HMOX1, FTH1, TTR, TF

Publications for Superficial Siderosis

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Articles related to Superficial Siderosis:

(show top 50)    (show all 243)
idTitleAuthorsYear
1
Cortical superficial siderosis, APOE genotype, and hemorrhage risk in cerebral amyloid angiopathy. (25716363)
2015
2
Time-resolved imaging of contrast kinetics imaging showing a vertebral hemangioma in CNS superficial siderosis. (25234095)
2014
3
Interrelationship of superficial siderosis and microbleeds in cerebral amyloid angiopathy. (25320098)
2014
4
CSF biomarkers in superficial siderosis: a new tool for diagnosis and evaluation of therapeutic efficacy of deferiprone--a case report. (24627229)
2014
5
Cerebral amyloid angiopathy: amyloid spells and cortical superficial siderosis. (25359331)
2014
6
High noon back pain- severe pseudoradicular pain as a lead symptom of superficial siderosis: a case report. (25371709)
2014
7
Superficial siderosis of the central nervous system presenting with dysuria initially. (24698546)
2014
8
Spinal intradural extramedullary cavernous angioma presenting with superficial siderosis and hydrocephalus: a case report and review of the literature. (25130126)
2014
9
Superficial siderosis of the central nervous system as a presentation of stage iv melanoma. (24856369)
2014
10
Superficial siderosis associated with aceruloplasminemia. Case report. (24607334)
2014
11
Neuropathology of cortical superficial siderosis and cerebral amyloid angiopathy: new insights, new questions. (24281141)
2013
12
Teaching neuroImages: MRI changes in superficial siderosis. (22547776)
2012
13
Progression and management of superficial siderosis. (22342237)
2012
14
Superficial siderosis associated with multiple dural tears opening into a spinal epidural fluid collection. (21748941)
2011
15
A patient with superficial siderosis, intraspinal cyst, low-pressure headache and low-lying cord. (22368982)
2011
16
Superficial siderosis in cerebral amyloid angiopathy. (21654928)
2011
17
Superficial siderosis of the central nervous system: phenotype and implications for audiology and otology. (21730883)
2011
18
Superficial siderosis of the CNS. (21700976)
2011
19
Cochlear implantation in a patient with superficial siderosis: an update. (20015783)
2010
20
Superficial siderosis mimicking amyotrophic lateral sclerosis. (20215988)
2010
21
Superficial siderosis of the central nervous system manifested with seizures. (20006512)
2010
22
Intraventricular cavernous malformation with superficial siderosis. (20457968)
2010
23
Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy. (20975060)
2010
24
Iron localization in superficial siderosis of the central nervous system. (18694445)
2009
25
Cochlear implant patients with superficial siderosis. (19594083)
2009
26
Superficial siderosis: sealing the defect. (19221303)
2009
27
Cognitive impairment in superficial siderosis of the central nervous system: a case report. (18937022)
2009
28
Superficial siderosis revealed by isolated cognitive impairment. (19196635)
2009
29
Systemic sclerosis and superficial siderosis of the central nervous system: casuality or causality? (18193230)
2008
30
Cerebellar atrophy revealing superficial siderosis. (18795601)
2008
31
The pathology of superficial siderosis of the central nervous system. (18696091)
2008
32
Cognitive and social impairments in patients with superficial siderosis. (15788543)
2005
33
Superficial siderosis from spinal teratoma. (12443590)
2002
34
Neuro-otologic findings in a case of superficial siderosis with bilateral hearing impairment. (11771051)
2001
35
Superficial siderosis of the central nervous system in a patient with neurofibromatosis type I. (10686476)
2000
36
Superficial siderosis of the central nervous system. A case report on examination by ECoG and DPOAE. (10965263)
2000
37
Evidence for preganglionic pupillary involvement in superficial siderosis. (10496281)
1999
38
Elevated CSF lactoferrin in superficial siderosis of the central nervous system. (10552243)
1999
39
Superficial siderosis of the central nervous system and anticoagulant therapy: a case report. (10551912)
1999
40
Secondary superficial siderosis of the central nervous system in a patient presenting with sensorineural hearing loss. (9638673)
1998
41
Neuroradiology case of the day. Myxopapillary ependymoma of the conus medullaris or filum terminale resulting in superficial siderosis and dissemination of tumor along CSF pathways. (9599402)
1998
42
Morphological and functional study of a case of superficial siderosis of the central nervous system. (9239533)
1997
43
Focal dystonia secondary to superficial siderosis. (8813232)
1996
44
Superficial siderosis of the brain: roles for cerebrospinal fluid circulation, iron and the hydroxyl radical. (8910872)
1996
45
Superficial siderosis of the central nervous system: a neglected cause of sensorineural hearing loss. (1528605)
1992
46
Superficial siderosis of the brain following unexplained subarachnoid hemorrhage: MRI diagnosis and clinical significance. (1407522)
1992
47
Superficial siderosis of the central nervous system. A 37-year follow-up of a case and review of the literature. (1832307)
1991
48
Superficial siderosis of the central nervous system. (2926762)
1989
49
High-field MR imaging of superficial siderosis of the central nervous system. (4031180)
1985
50
Superficial siderosis of the central nervous system. (5100703)
1971

Variations for Superficial Siderosis

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Expression for genes affiliated with Superficial Siderosis

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Search GEO for disease gene expression data for Superficial Siderosis.

Pathways for genes affiliated with Superficial Siderosis

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Pathways related to Superficial Siderosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3FTH1, TF
2
Show member pathways
tetrapyrrole biosynthesis36
heme degradation36
Heme Biosynthesis36
heme biosynthesis36
heme biosynthesis from uroporphyrinogen-III I36
9.1HMOX1, FTH1
39.0TF, HMOX1
49.0HMOX1, TF
5
Show member pathways
8.5HMOX1, TF, FTH1
68.5HMOX1, FTH1, TF
7
Show member pathways
8.5TF, FTH1, HMOX1

Compounds for genes affiliated with Superficial Siderosis

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Compounds related to Superficial Siderosis according to GeneCards Suite gene sharing:

(show all 43)
idCompoundScoreTop Affiliating Genes
1ferrous ammonium sulfate439.8TF, FTH1
2iron dextran43 1210.8TF, FTH1
3apotransferrin439.8FTH1, TF
4tbps43 2810.7TF, TTR
5fe3+439.7TF, FTH1
6tocopherol439.7TF, TTR
7fe2+439.7TF, FTH1
8glutaraldehyde439.7TF, TTR
9vitamin b12439.7TTR, TF
10betacarotene439.7TF, TTR
11adenine43 24 1211.6TTR, TF
12carbohydrates439.6TTR, TF
13thyroxine43 2410.6TF, TTR
14copper43 2410.6TF, FTH1
15folate439.5TTR, TF
16salicylic acid43 2810.5HMOX1, TTR
17zinc protoporphyrin439.4TF, HMOX1
18fenton439.4HMOX1, TF
19protoporphyrin ix43 24 1211.4HMOX1, TF
20resveratrol43 59 24 1212.4HMOX1, TTR
218-isoprostane439.4HMOX1, TF
22vitamin a43 24 1211.4TF, TTR
23phenobarbital43 28 49 1212.4TF, HMOX1
24polyethylene glycol439.4HMOX1, TF
25sodium nitroprusside439.3TF, HMOX1
26carbon439.3HMOX1, FTH1
27nifedipine43 28 49 1212.3HMOX1, TF
28citrate439.3HMOX1, TF
29agar439.2TF, TTR
30prostacyclin439.2HMOX1, TF
31heme28 24 1211.1HMOX1, TF
32aspirin43 49 28 2412.1HMOX1, TTR
33epinephrine43 24 1211.0TTR, TF
34n acetylcysteine439.0TF, HMOX1
35deferoxamine43 129.9HMOX1, TF, FTH1
36alpha tocopherol438.9TF, TTR, HMOX1
37norepinephrine43 24 1210.9TF, TTR, HMOX1
38cyclosporin a43 28 5910.9TF, HMOX1, TTR
39lactate438.9HMOX1, TTR, TF
40alanine438.8HMOX1, TF, TTR
41estrogen438.8HMOX1, TF, TTR
42ascorbic acid43 249.4TF, HMOX1, TTR, FTH1
43iron43 249.4TF, HMOX1, TTR, FTH1

GO Terms for genes affiliated with Superficial Siderosis

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Cellular components related to Superficial Siderosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.5HMOX1, TTR, TF

Biological processes related to Superficial Siderosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transmembrane transportGO:00550858.5HMOX1, FTH1, TF
2cellular iron ion homeostasisGO:00068798.2HMOX1, FTH1, TF

Molecular functions related to Superficial Siderosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ferric iron bindingGO:00081999.3FTH1, TF

Products for genes affiliated with Superficial Siderosis

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  • Antibodies
  • Proteins
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  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Superficial Siderosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet