MCID: SPR066
MIFTS: 33

Superficial Siderosis malady

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Superficial Siderosis

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Sources:
52Orphanet, 29ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Superficial Siderosis:

Name: Superficial Siderosis 52

Characteristics:

Orphanet epidemiological data:

52
superficial siderosis:
Inheritance: Not applicable; Age of onset: All ages

Classifications:



External Ids:

Orphanet52 ORPHA247245
ICD10 via Orphanet29 I69.0

Summaries for Superficial Siderosis

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Wikipedia:69 Superficial hemosiderosis of the central nervous system is a disease of the brain resulting from chronic... more...

MalaCards based summary: Superficial Siderosis is related to superficial siderosis of the central nervous system and siderosis. An important gene associated with Superficial Siderosis is FTH1 (Ferritin Heavy Chain 1), and among its related pathways are Iron metabolism in placenta and HIF-1 signaling pathway. Affiliated tissues include brain, spinal cord and bone, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Related Diseases for Superficial Siderosis

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Graphical network of the top 20 diseases related to Superficial Siderosis:



Diseases related to superficial siderosis

Symptoms for Superficial Siderosis

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Drugs & Therapeutics for Superficial Siderosis

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Drugs for Superficial Siderosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
IronPhase 410807439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
 
Ed-In-Sol
Eisen
Electrolytic iron
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feronate
Ferretts
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
Ferrum metallicum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron powder
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, carbonyl
Iron, electrolytic
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
Iron, reduced
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Reduced iron
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Vitedyn-Slo
Yieronia
fer
ferrous iron
hierro
2
DeferipronePhase 45630652-11-02972
Synonyms:
1,2-Dimethyl-3-hydroxypyrid-4-one
3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
APO-066
CP-20
DN-180-01-AF
Deferipron
 
Deferiprona
Deferiproni
Deferipronum
Deferypron
Dimethylhydroxypyridone
Défériprone
Ferriprox
PL-1

Interventional clinical trials:

idNameStatusNCT IDPhase
1Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial SiderosisActive, not recruitingNCT01284127Phase 4
2Superficial Siderosis in Patients With Suspected Cerebral Amyloid AngiopathyActive, not recruitingNCT01856699
3Florbetaben as an Amyloid Plaque Marker in Elderly Patients With Focal or Disseminated Superficial HemosiderosisNot yet recruitingNCT02664571

Search NIH Clinical Center for Superficial Siderosis

Genetic Tests for Superficial Siderosis

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Anatomical Context for Superficial Siderosis

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MalaCards organs/tissues related to Superficial Siderosis:

34
Brain, Spinal cord, Bone, Testes, Bone marrow

Animal Models for Superficial Siderosis or affiliated genes

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MGI Mouse Phenotypes related to Superficial Siderosis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8FTH1, HMOX1, LTF
2MP:00053978.0FTH1, HMOX1, LTF, TF
3MP:00053768.0FTH1, HMOX1, LTF, TF

Publications for Superficial Siderosis

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Articles related to Superficial Siderosis:

(show top 50)    (show all 278)
idTitleAuthorsYear
1
Cortical superficial siderosis: Prevalence and biomarker profile in a memory clinic population. (27534713)
2016
2
An autopsy case of superficial siderosis of the central nervous system accompanied by anterior sacral polycystic meningocele in neurofibromatosis type 1. (27356733)
2016
3
Intraspinal hemorrhage in spontaneous intracranial hypotension: link to superficial siderosis? Report of 2 cases. (26588500)
2016
4
Cortical superficial siderosis, APOE genotype, and hemorrhage risk in cerebral amyloid angiopathy. (25716363)
2015
5
Bilateral Vestibulopathy Documented by Video Head Impulse Tests in Superficial Siderosis. (26440725)
2015
6
Superficial siderosis of the central nervous system induced by a single-episode of traumatic subarachnoid hemorrhage: a study using MRI-enhanced gradient echo T2 star-weighted angiography. (25647424)
2015
7
Time-resolved imaging of contrast kinetics imaging showing a vertebral hemangioma in CNS superficial siderosis. (25234095)
2014
8
CSF biomarkers in superficial siderosis: a new tool for diagnosis and evaluation of therapeutic efficacy of deferiprone--a case report. (24627229)
2014
9
Neuropathology of cortical superficial siderosis and cerebral amyloid angiopathy: new insights, new questions. (24281141)
2013
10
Superficial siderosis and sudden sensorineural hearing loss: a case report and review of the literature. (23762708)
2013
11
Teaching neuroImages: MRI changes in superficial siderosis. (22547776)
2012
12
A patient with superficial siderosis, intraspinal cyst, low-pressure headache and low-lying cord. (22368982)
2011
13
Three cases of superficial siderosis of the central nervous system and review of the literature. (21822983)
2011
14
Superficial siderosis mimicking amyotrophic lateral sclerosis. (20215988)
2010
15
Superficial siderosis of the central nervous system manifested with seizures. (20006512)
2010
16
Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy. (20975060)
2010
17
Superficial siderosis of the central nervous system due to bilateral jugular vein thrombosis. (20937957)
2010
18
Further in-depth look at superficial siderosis (and intracranial hypotension). (20581071)
2010
19
Episodic encephalopathy due to an occult spinal vascular malformation complicated by superficial siderosis. (19857921)
2010
20
Neuroimaging in superficial siderosis: an in-depth look. (19729538)
2010
21
Iron localization in superficial siderosis of the central nervous system. (18694445)
2009
22
Cochlear implant patients with superficial siderosis. (19594083)
2009
23
Superficial siderosis revealed by isolated cognitive impairment. (19196635)
2009
24
Superficial siderosis. (19934584)
2009
25
Systemic sclerosis and superficial siderosis of the central nervous system: casuality or causality? (18193230)
2008
26
The pathology of superficial siderosis of the central nervous system. (18696091)
2008
27
Superficial siderosis of the central nervous system and its cochleovestibular consequences. (19137643)
2008
28
Unsuccessful cochlear implantation in two patients with superficial siderosis of the central nervous system. (18665029)
2008
29
Superficial siderosis due to papillary glioneuronal tumor. (17049863)
2006
30
Successful cochlear implantation in a patient with superficial siderosis. (16798402)
2006
31
Central nervous system superficial siderosis following spinal surgery. (15739535)
2005
32
Effects of shunting CSF in superficial siderosis of the CNS. (15037721)
2004
33
Superficial siderosis of the brain as a late complication of subarachnoid haemorrhage. (14534383)
2004
34
MRI findings in a case of a superficial siderosis associated with an ependymoma. (12297737)
2002
35
Superficial siderosis 20 years after brain tumour. (12849430)
2002
36
Neuro-otologic findings in a case of superficial siderosis with bilateral hearing impairment. (11771051)
2001
37
Superficial siderosis of the central nervous system in a patient with neurofibromatosis type I. (10686476)
2000
38
Surgical resection of a cerebral arteriovenous malformation for treatment of superficial siderosis: case report. (10940422)
2000
39
Elevated CSF lactoferrin in superficial siderosis of the central nervous system. (10552243)
1999
40
Superficial siderosis of the CNS as a rare differential diagnosis of chronic low back pain. (10552254)
1999
41
Secondary superficial siderosis of the central nervous system in a patient presenting with sensorineural hearing loss. (9638673)
1998
42
Neuroradiology case of the day. Myxopapillary ependymoma of the conus medullaris or filum terminale resulting in superficial siderosis and dissemination of tumor along CSF pathways. (9599402)
1998
43
Calcified filum terminale paraganglioma causing superficial siderosis. (9609190)
1998
44
Morphological and functional study of a case of superficial siderosis of the central nervous system. (9239533)
1997
45
Superficial siderosis--a cause of audiovestibular failure. (8816109)
1996
46
Superficial siderosis of the central nervous system: a neglected cause of sensorineural hearing loss. (1528605)
1992
47
Superficial siderosis of the brain following unexplained subarachnoid hemorrhage: MRI diagnosis and clinical significance. (1407522)
1992
48
Superficial siderosis of the central nervous system. A 37-year follow-up of a case and review of the literature. (1832307)
1991
49
High-field MR imaging of superficial siderosis of the central nervous system. (4031180)
1985
50
Superficial siderosis of the central nervous system. (5100703)
1971

Variations for Superficial Siderosis

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Expression for genes affiliated with Superficial Siderosis

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Search GEO for disease gene expression data for Superficial Siderosis.

Pathways for genes affiliated with Superficial Siderosis

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Pathways related to Superficial Siderosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.4FTH1, TF
29.3HMOX1, TF
39.3HMOX1, TF
48.8FTH1, HMOX1, TF
5
Show member pathways
8.8FTH1, HMOX1, TF
6
Show member pathways
8.0FTH1, HMOX1, LTF, TF

GO Terms for genes affiliated with Superficial Siderosis

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Cellular components related to Superficial Siderosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.5HMOX1, LTF, TF

Biological processes related to Superficial Siderosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1iron ion homeostasisGO:00550729.7HMOX1, TF
2retina homeostasisGO:00018959.2LTF, TF
3positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.0HMOX1, LTF
4cellular iron ion homeostasisGO:00068798.7FTH1, HMOX1, TF

Molecular functions related to Superficial Siderosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ferric iron bindingGO:00081999.9FTH1, TF
2iron ion bindingGO:00055069.1FTH1, LTF

Sources for Superficial Siderosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet