MCID: SPR066
MIFTS: 26

Superficial Siderosis malady

Neuronal diseases category

Summaries for Superficial Siderosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Superficial hemosiderosis of the central nervous system is a disease of the brain resulting from chronic... more...

MalaCards: Superficial Siderosis is related to siderosis and cerebritis. An important gene associated with Superficial Siderosis is FTH1 (ferritin, heavy polypeptide 1), and among its related pathways are Iron metabolism in placenta and HIF-1 signaling pathway. The compounds ferrous ammonium sulfate and apotransferrin have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Superficial Siderosis

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Sources:
48Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
superficial siderosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

superficial siderosis 48


External Ids:

ICD10 via Orphanet26 I69.0

Related Diseases for Superficial Siderosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Superficial Siderosis:



Diseases related to superficial siderosis

Clinical Features for Superficial Siderosis

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Drugs & Therapeutics for Superficial Siderosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Superficial Siderosis

Drug clinical trials:

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Search NIH Clinical Center for Superficial Siderosis

Search CenterWatch for Superficial Siderosis

Genetic Tests for Superficial Siderosis

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Anatomical Context for Superficial Siderosis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Superficial Siderosis:

32
Brain

Animal Models for Superficial Siderosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Superficial Siderosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0HMOX1, TTR, FTH1, TF

Publications for Superficial Siderosis

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Genetic Variations for Superficial Siderosis

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Expression for genes affiliated with Superficial Siderosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Superficial Siderosis

Search GEO for disease gene expression data for Superficial Siderosis.

Pathways for genes affiliated with Superficial Siderosis

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Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome
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Pathways related to Superficial Siderosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3TF, FTH1
29.0HMOX1, TF
39.0HMOX1, TF
4
Hide members
8.5HMOX1, FTH1, TF
58.5HMOX1, FTH1, TF
6
Hide members
8.5HMOX1, FTH1, TF

Compounds for genes affiliated with Superficial Siderosis

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Superficial Siderosis according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1ferrous ammonium sulfate449.7FTH1, TF
2apotransferrin449.7FTH1, TF
3iron dextran44 1110.7FTH1, TF
4tbps44 2810.7TF, TTR
5fe3+449.7TF, FTH1
6tocopherol449.7TTR, TF
7fe2+449.7TF, FTH1
8glutaraldehyde449.7TF, TTR
9vitamin b12449.6TTR, TF
10betacarotene449.6TTR, TF
11zinc protoporphyrin449.4TF, HMOX1
12salicylic acid44 2810.4TTR, HMOX1
13fenton449.4HMOX1, TF
14protoporphyrin ix44 11 2411.4HMOX1, TF
15adenine44 11 2411.4TF, TTR
168-isoprostane449.4HMOX1, TF
17resveratrol44 59 11 2412.3HMOX1, TTR
18carbohydrates449.3TTR, TF
19phenobarbital44 28 1111.3HMOX1, TF
20polyethylene glycol449.3HMOX1, TF
21sodium nitroprusside449.3TF, HMOX1
22thyroxine44 2410.2TTR, TF
23nifedipine44 49 28 1112.2HMOX1, TF
24citrate449.1HMOX1, TF
25carbon449.1HMOX1, FTH1
26copper44 2410.0FTH1, TF
27deferoxamine44 119.9HMOX1, FTH1, TF
28alpha tocopherol448.9TF, TTR, HMOX1
29norepinephrine44 11 2410.9TF, TTR, HMOX1
30cyclosporin a44 28 5910.8HMOX1, TTR, TF
31lactate448.8TF, TTR, HMOX1
32alanine448.7HMOX1, TTR, TF
33estrogen448.7TF, TTR, HMOX1
34ascorbic acid44 249.4HMOX1, TTR, FTH1, TF
35iron44 249.4TF, FTH1, TTR, HMOX1

GO Terms for genes affiliated with Superficial Siderosis

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16Gene Ontology
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Biological processes related to Superficial Siderosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane transportGO:0550858.5HMOX1, FTH1, TF
2cellular iron ion homeostasisGO:0068798.2HMOX1, FTH1, TF

Molecular functions related to Superficial Siderosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferric iron bindingGO:0081999.3FTH1, TF

Products for genes affiliated with Superficial Siderosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Superficial Siderosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet