MCID: SPR066
MIFTS: 38

Superficial Siderosis malady

Neuronal diseases, Rare diseases categories
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Summaries for Superficial Siderosis

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Wikipedia:65 Superficial hemosiderosis of the central nervous system is a disease of the brain resulting from chronic... more...

MalaCards based summary: Superficial Siderosis is related to siderosis and superficial siderosis of the central nervous system. An important gene associated with Superficial Siderosis is FTH1 (ferritin, heavy polypeptide 1), and among its related pathways are Iron metabolism in placenta and Metabolism of porphyrins. The compounds ferrous ammonium sulfate and iron dextran have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and spinal cord, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Superficial Siderosis

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Sources:
48Orphanet, 26ICD10 via Orphanet
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Superficial Siderosis, Aliases & Descriptions:

Name: Superficial Siderosis 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
superficial siderosis:
Inheritance: Sporadic; Age of onset: Variable


External Ids:

ICD10 via Orphanet26 I69.0

Related Diseases for Superficial Siderosis

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Graphical network of the top 20 diseases related to Superficial Siderosis:



Diseases related to superficial siderosis

Symptoms for Superficial Siderosis

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Drugs & Therapeutics for Superficial Siderosis

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Drug clinical trials:

Search ClinicalTrials for Superficial Siderosis

Search NIH Clinical Center for Superficial Siderosis

Genetic Tests for Superficial Siderosis

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Anatomical Context for Superficial Siderosis

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MalaCards organs/tissues related to Superficial Siderosis:

32
Brain, Bone, Spinal cord, Bone marrow

Animal Models for Superficial Siderosis or affiliated genes

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MGI Mouse Phenotypes related to Superficial Siderosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0HMOX1, FTH1, TTR, TF

Publications for Superficial Siderosis

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Articles related to Superficial Siderosis:

(show top 50)    (show all 236)
idTitleAuthorsYear
1
Time-resolved imaging of contrast kinetics imaging showing a vertebral hemangioma in CNS superficial siderosis. (25234095)
2014
2
Interrelationship of superficial siderosis and microbleeds in cerebral amyloid angiopathy. (25320098)
2014
3
CSF biomarkers in superficial siderosis: a new tool for diagnosis and evaluation of therapeutic efficacy of deferiprone--a case report. (24627229)
2014
4
Cerebral amyloid angiopathy: amyloid spells and cortical superficial siderosis. (25359331)
2014
5
High noon back pain- severe pseudoradicular pain as a lead symptom of superficial siderosis: a case report. (25371709)
2014
6
Superficial siderosis of the central nervous system presenting with dysuria initially. (24698546)
2014
7
Spinal intradural extramedullary cavernous angioma presenting with superficial siderosis and hydrocephalus: a case report and review of the literature. (25130126)
2014
8
Superficial siderosis of the central nervous system as a presentation of stage iv melanoma. (24856369)
2014
9
Superficial siderosis associated with aceruloplasminemia. Case report. (24607334)
2014
10
Neuropathology of cortical superficial siderosis and cerebral amyloid angiopathy: new insights, new questions. (24281141)
2013
11
Teaching neuroImages: MRI changes in superficial siderosis. (22547776)
2012
12
Progression and management of superficial siderosis. (22342237)
2012
13
Superficial siderosis associated with multiple dural tears opening into a spinal epidural fluid collection. (21748941)
2011
14
A patient with superficial siderosis, intraspinal cyst, low-pressure headache and low-lying cord. (22368982)
2011
15
Superficial siderosis in cerebral amyloid angiopathy. (21654928)
2011
16
Superficial siderosis of the central nervous system: phenotype and implications for audiology and otology. (21730883)
2011
17
Superficial siderosis of the CNS. (21700976)
2011
18
Cochlear implantation in a patient with superficial siderosis: an update. (20015783)
2010
19
Superficial siderosis mimicking amyotrophic lateral sclerosis. (20215988)
2010
20
Superficial siderosis of the central nervous system manifested with seizures. (20006512)
2010
21
Intraventricular cavernous malformation with superficial siderosis. (20457968)
2010
22
Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy. (20975060)
2010
23
Iron localization in superficial siderosis of the central nervous system. (18694445)
2009
24
Cochlear implant patients with superficial siderosis. (19594083)
2009
25
Superficial siderosis: sealing the defect. (19221303)
2009
26
Cognitive impairment in superficial siderosis of the central nervous system: a case report. (18937022)
2009
27
Superficial siderosis revealed by isolated cognitive impairment. (19196635)
2009
28
Systemic sclerosis and superficial siderosis of the central nervous system: casuality or causality? (18193230)
2008
29
Cerebellar atrophy revealing superficial siderosis. (18795601)
2008
30
The pathology of superficial siderosis of the central nervous system. (18696091)
2008
31
Cognitive and social impairments in patients with superficial siderosis. (15788543)
2005
32
MRI findings in a case of a superficial siderosis associated with an ependymoma. (12297737)
2002
33
Superficial siderosis from spinal teratoma. (12443590)
2002
34
Neuro-otologic findings in a case of superficial siderosis with bilateral hearing impairment. (11771051)
2001
35
Superficial siderosis of the central nervous system in a patient with neurofibromatosis type I. (10686476)
2000
36
Superficial siderosis of the central nervous system. A case report on examination by ECoG and DPOAE. (10965263)
2000
37
Evidence for preganglionic pupillary involvement in superficial siderosis. (10496281)
1999
38
Elevated CSF lactoferrin in superficial siderosis of the central nervous system. (10552243)
1999
39
Superficial siderosis of the central nervous system and anticoagulant therapy: a case report. (10551912)
1999
40
Secondary superficial siderosis of the central nervous system in a patient presenting with sensorineural hearing loss. (9638673)
1998
41
Neuroradiology case of the day. Myxopapillary ependymoma of the conus medullaris or filum terminale resulting in superficial siderosis and dissemination of tumor along CSF pathways. (9599402)
1998
42
Morphological and functional study of a case of superficial siderosis of the central nervous system. (9239533)
1997
43
Focal dystonia secondary to superficial siderosis. (8813232)
1996
44
Superficial siderosis of the brain: roles for cerebrospinal fluid circulation, iron and the hydroxyl radical. (8910872)
1996
45
Superficial siderosis of the central nervous system: a neglected cause of sensorineural hearing loss. (1528605)
1992
46
Superficial siderosis of the brain following unexplained subarachnoid hemorrhage: MRI diagnosis and clinical significance. (1407522)
1992
47
Superficial siderosis of the central nervous system. A 37-year follow-up of a case and review of the literature. (1832307)
1991
48
Superficial siderosis of the central nervous system. (2926762)
1989
49
High-field MR imaging of superficial siderosis of the central nervous system. (4031180)
1985
50
Superficial siderosis of the central nervous system. (5100703)
1971

Variations for Superficial Siderosis

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Expression for genes affiliated with Superficial Siderosis

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Expression patterns in normal tissues for genes affiliated with Superficial Siderosis

Search GEO for disease gene expression data for Superficial Siderosis.

Pathways for genes affiliated with Superficial Siderosis

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Pathways related to Superficial Siderosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3FTH1, TF
2
Show member pathways
tetrapyrrole biosynthesis37
heme degradation37
Heme Biosynthesis37
heme biosynthesis37
heme biosynthesis from uroporphyrinogen-III I37
9.1FTH1, HMOX1
39.0HMOX1, TF
49.0HMOX1, TF
5
Show member pathways
8.5HMOX1, FTH1, TF
68.5HMOX1, FTH1, TF
7
Show member pathways
8.5HMOX1, FTH1, TF

Compounds for genes affiliated with Superficial Siderosis

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Compounds related to Superficial Siderosis according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1ferrous ammonium sulfate449.8TF, FTH1
2iron dextran44 1110.8TF, FTH1
3apotransferrin449.8TF, FTH1
4tbps44 2810.7TF, TTR
5fe3+449.7TF, FTH1
6tocopherol449.7TTR, TF
7fe2+449.7FTH1, TF
8glutaraldehyde449.7TTR, TF
9vitamin b12449.7TF, TTR
10betacarotene449.7TTR, TF
11adenine44 24 1111.6TF, TTR
12carbohydrates449.6TTR, TF
13thyroxine44 2410.6TTR, TF
14copper44 2410.6TF, FTH1
15folate449.5TTR, TF
16salicylic acid44 2810.5HMOX1, TTR
17zinc protoporphyrin449.4HMOX1, TF
18fenton449.4HMOX1, TF
19protoporphyrin ix44 24 1111.4HMOX1, TF
20resveratrol44 61 24 1112.4HMOX1, TTR
218-isoprostane449.4HMOX1, TF
22vitamin a44 24 1111.4TTR, TF
23phenobarbital44 28 50 1112.4TF, HMOX1
24polyethylene glycol449.4HMOX1, TF
25sodium nitroprusside449.3HMOX1, TF
26carbon449.3HMOX1, FTH1
27nifedipine44 28 50 1112.3TF, HMOX1
28citrate449.3HMOX1, TF
29agar449.2TTR, TF
30prostacyclin449.2TF, HMOX1
31heme28 24 1111.1HMOX1, TF
32aspirin44 50 28 2412.1TTR, HMOX1
33epinephrine44 24 1111.0TTR, TF
34n acetylcysteine449.0HMOX1, TF
35deferoxamine44 119.9TF, FTH1, HMOX1
36alpha tocopherol448.9HMOX1, TTR, TF
37norepinephrine44 24 1110.9TF, TTR, HMOX1
38cyclosporin a44 28 6110.9TF, TTR, HMOX1
39lactate448.9TF, TTR, HMOX1
40alanine448.8HMOX1, TTR, TF
41estrogen448.8TF, TTR, HMOX1
42ascorbic acid44 249.4HMOX1, FTH1, TTR, TF
43iron44 249.4HMOX1, FTH1, TTR, TF

GO Terms for genes affiliated with Superficial Siderosis

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Cellular components related to Superficial Siderosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5HMOX1, TTR, TF

Biological processes related to Superficial Siderosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane transportGO:0550858.5HMOX1, FTH1, TF
2cellular iron ion homeostasisGO:0068798.2HMOX1, FTH1, TF

Molecular functions related to Superficial Siderosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferric iron bindingGO:0081999.3FTH1, TF

Products for genes affiliated with Superficial Siderosis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Superficial Siderosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet