MCID: SPR066
MIFTS: 34

Superficial Siderosis malady

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Superficial Siderosis

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Sources:
31ICD10 via Orphanet, 54Orphanet
See all MalaCards sources

Aliases & Descriptions for Superficial Siderosis:

Name: Superficial Siderosis 54

Characteristics:

Orphanet epidemiological data:

54
superficial siderosis:
Inheritance: Not applicable; Age of onset: All ages

Classifications:



External Ids:

Orphanet54 ORPHA247245
ICD10 via Orphanet31 I69.0

Summaries for Superficial Siderosis

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Wikipedia:71 Superficial hemosiderosis of the central nervous system is a disease of the brain resulting from chronic... more...

MalaCards based summary: Superficial Siderosis is related to superficial siderosis of the central nervous system and siderosis. An important gene associated with Superficial Siderosis is FTH1 (Ferritin Heavy Chain 1), and among its related pathways are NRF2 pathway and Iron metabolism in placenta. Affiliated tissues include brain, spinal cord and bone, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Related Diseases for Superficial Siderosis

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Graphical network of the top 20 diseases related to Superficial Siderosis:



Diseases related to superficial siderosis

Symptoms & Phenotypes for Superficial Siderosis

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MGI Mouse Phenotypes related to Superficial Siderosis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8FTH1, HMOX1, LTF
2MP:00053978.7FTH1, HMOX1, LTF, TF

Drugs & Therapeutics for Superficial Siderosis

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Drugs for Superficial Siderosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
IronapprovedPhase 411657439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
 
Ed-In-Sol
Eisen
Electrolytic iron
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feronate
Ferretts
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
Ferrum metallicum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron powder
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, carbonyl
Iron, electrolytic
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
Iron, reduced
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Reduced iron
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Vitedyn-Slo
Yieronia
fer
ferrous iron
hierro
2
DeferiproneapprovedPhase 45730652-11-02972
Synonyms:
1,2-Dimethyl-3-hydroxypyrid-4-one
3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
APO-066
CP-20
DN-180-01-AF
Deferipron
 
Deferiprona
Deferiproni
Deferipronum
Deferypron
Dimethylhydroxypyridone
Défériprone
Ferriprox
PL-1
3Iron Chelating AgentsPhase 4226
4Chelating AgentsPhase 41423

Interventional clinical trials:

idNameStatusNCT IDPhase
1Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial SiderosisActive, not recruitingNCT01284127Phase 4
2Superficial Siderosis in Patients With Suspected Cerebral Amyloid AngiopathyActive, not recruitingNCT01856699
3Florbetaben as an Amyloid Plaque Marker in Elderly Patients With Focal or Disseminated Superficial HemosiderosisNot yet recruitingNCT02664571

Search NIH Clinical Center for Superficial Siderosis

Genetic Tests for Superficial Siderosis

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Anatomical Context for Superficial Siderosis

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MalaCards organs/tissues related to Superficial Siderosis:

36
Brain, Spinal cord, Bone, Testes, Bone marrow

Publications for Superficial Siderosis

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Articles related to Superficial Siderosis:

(show top 50)    (show all 288)
idTitleAuthorsYear
1
Cortical superficial siderosis and first-ever cerebral hemorrhage in cerebral amyloid angiopathy. (28356458)
2017
2
Characterizing Deep White Matter Hyperintensities in Patients with Symptomatic Isolated Cortical Superficial Siderosis. (28089561)
2017
3
Superficial siderosis and dural ectasia: A case report. (27754910)
2016
4
An autopsy case of superficial siderosis of the central nervous system accompanied by anterior sacral polycystic meningocele in neurofibromatosis type 1. (27356733)
2016
5
Superficial Siderosis after Germinal Matrix Hemorrhage. (27633808)
2016
6
IV and V cranial nerves dysfunction as initial manifestations of superficial siderosis of the central nervous system. (26988173)
2016
7
Chronic dorsal subdural haematoma: single aetiology for CNS superficial siderosis and myelopathy. (27055529)
2016
8
Deferiprone Reduces Hemosiderin Deposition in Superficial Siderosis. (27788692)
2016
9
Sporadic cerebral amyloid angiopathy as a cause of relapsing lobar hemorrhage, convexal subarachnoid hemorrhage and cortical superficial siderosis. (27259571)
2016
10
Case report: Superficial siderosis after brachial plexus avulsion. (26914142)
2016
11
Spinal subarachnoid hemorrhage in cortical superficial siderosis after apixaban and clopidogrel therapy. (26837378)
2016
12
Superficial Siderosis. (27685823)
2016
13
Cochlear implantation is a therapeutic option for superficial siderosis patients with sensorineural hearing loss. (26857965)
2016
14
Cortical superficial siderosis: Prevalence and biomarker profile in a memory clinic population. (27534713)
2016
15
Superficial siderosis associated with peripheral autonomic failure and tetraventricular hydrocephalus: a case report. (27498096)
2016
16
Cortical superficial siderosis predicts early recurrent lobar hemorrhage. (27694268)
2016
17
Intraspinal hemorrhage in spontaneous intracranial hypotension: link to superficial siderosis? Report of 2 cases. (26588500)
2016
18
An autopsy case of cortical superficial siderosis with persistent abnormal behavior. (27090856)
2016
19
Cortical Superficial Siderosis Presumed due to Cerebral Amyloid Angiopathy: Minimum Standards for Rating and Reporting. (26915571)
2016
20
Corticobasal Syndrome Due to Superficial Siderosis Caused by Thalamic Cavernoma. (26844964)
2016
21
Cerebral Amyloid Angiopathy as an Etiology for Cortical Superficial Siderosis: An Unproven Hypothesis. (26721767)
2016
22
Cerebrospinal Fluid Alzheimer's Disease Biomarkers in Isolated Supratentorial Cortical Superficial Siderosis. (27567848)
2016
23
Aneurysmal wall imaging in a case of cortical superficial siderosis and multiple unruptured aneurysms. (27873743)
2016
24
Familial amyloid polyneuropathy involving a homozygous Val30Met mutation in the amyloidogenic transthyretin gene presenting with superficial siderosis: a case report. (27212678)
2016
25
The value of eZIS analysis of Tc-99m ECD SPECT on identifying cerebellar hypoperfusion in a patient with superficial siderosis: A case report. (27893680)
2016
26
Infratentorial superficial siderosis: Classification, diagnostic criteria and rational investigation pathway. (28019651)
2016
27
Cerebral Microbleeds and Cortical Superficial Siderosis in Patients Presenting With Minor Cerebrovascular Events. (27507863)
2016
28
Cortical Superficial Siderosis in Memory Clinic Patients: Further Evidence for Underlying Cerebral Amyloid Angiopathy. (26751369)
2016
29
Superficial siderosis syndrome with progressive hearing loss and bilateral vestibular failure, 51 years after a neurosurgical procedure: diagnostic value of combined MRI and video head impulse test. (27981351)
2016
30
Intracranial dural arteriovenous fistula as a cause for symptomatic superficial siderosis: A report of two cases and review of the literature. (27127712)
2016
31
Superficial siderosis complicated by hydrocephalus: bleeding from the dura mater in the cerebrospinal fluid cavity after brain tumor surgery. (27117905)
2016
32
Superficial Siderosis of the Central Nervous System Originating from the Thoracic Spine: A Case Report. (27437021)
2016
33
The Characteristics of Superficial Siderosis and Convexity Subarachnoid Hemorrhage and Clinical Relevance in Suspected Cerebral Amyloid Angiopathy. (25871492)
2015
34
Cochlear Implantation in Patients With Superficial Siderosis: Seven Cases and Systematic Review of the Literature. (26065403)
2015
35
Bilateral Vestibulopathy Documented by Video Head Impulse Tests in Superficial Siderosis. (26440725)
2015
36
Superficial siderosis of the central nervous system with seizures onset. (26512155)
2015
37
Superficial siderosis of central nervous system of unknown cause. (25713424)
2015
38
Prevalence of superficial siderosis following singular, acute aneurysmal subarachnoid hemorrhage. (25534525)
2015
39
Cortical superficial siderosis, APOE genotype, and hemorrhage risk in cerebral amyloid angiopathy. (25716363)
2015
40
Cortical superficial siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions. (26115675)
2015
41
Superficial siderosis of the central nervous system induced by a single-episode of traumatic subarachnoid hemorrhage: a study using MRI-enhanced gradient echo T2 star-weighted angiography. (25647424)
2015
42
Cortical superficial siderosis: a marker of vascular amyloid in patients with cognitive impairment. (25632096)
2015
43
Superficial siderosis of the central nervous system: A case report. (25780438)
2015
44
Diagnostic Significance of Cortical Superficial Siderosis for Alzheimer Disease in Patients with Cognitive Impairment. (26450535)
2015
45
Cortical Superficial Siderosis and Risk of Bleeding after Thrombolysis for Ischemic Stroke. (26351845)
2015
46
Superficial siderosis following spontaneous intracranial hypotension. (26139598)
2015
47
Clinical spectrum, underlying etiologies and radiological characteristics of cortical superficial siderosis. (25860345)
2015
48
Superficial siderosis of the central nervous system associated with incomplete dural closure following posterior fossa surgery: report of 3 cases. (26067619)
2015
49
Cervical Spinal Meningeal Melanocytoma Presenting as Intracranial Superficial Siderosis. (26770862)
2015
50
Superficial siderosis of the central nervous system. (26240112)
2015

Variations for Superficial Siderosis

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Expression for genes affiliated with Superficial Siderosis

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Search GEO for disease gene expression data for Superficial Siderosis.

Pathways for genes affiliated with Superficial Siderosis

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Pathways related to Superficial Siderosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.4FTH1, HMOX1
29.1FTH1, TF
39.1HMOX1, TF
49.1HMOX1, TF
5
Show member pathways
8.6FTH1, HMOX1, TF
6
Show member pathways
8.6FTH1, HMOX1, TF
78.6FTH1, HMOX1, TF
88.6FTH1, HMOX1, TF

GO Terms for genes affiliated with Superficial Siderosis

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Cellular components related to Superficial Siderosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tertiary granule lumenGO:19047249.3FTH1, LTF

Biological processes related to Superficial Siderosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.8HMOX1, LTF
2iron ion transportGO:00068269.7FTH1, TF
3cellular protein metabolic processGO:00442679.6LTF, TF
4cellular iron ion homeostasisGO:00068799.3FTH1, HMOX1, TF
5iron ion homeostasisGO:00550729.1HMOX1, LTF, TF
6retina homeostasisGO:00018959.0LTF, TF

Molecular functions related to Superficial Siderosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1iron ion bindingGO:000550610.1FTH1, LTF
2ferric iron bindingGO:00081999.9FTH1, TF
3metal ion bindingGO:00468728.0FTH1, HMOX1, LTF, TF

Sources for Superficial Siderosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet