MCID: SPR066
MIFTS: 31

Superficial Siderosis malady

Neuronal diseases, Rare diseases categories

Aliases & Classifications for Superficial Siderosis

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Sources:
51Orphanet, 28ICD10 via Orphanet
See all sources

Aliases & Descriptions for Superficial Siderosis:

Name: Superficial Siderosis 51


Classifications:



Characteristics (Orphanet epidemiological data):

51
superficial siderosis:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Orphanet51 247245
ICD10 via Orphanet28 I69.0

Summaries for Superficial Siderosis

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Wikipedia:68 Superficial hemosiderosis of the central nervous system is a disease of the brain resulting from chronic... more...

MalaCards based summary: Superficial Siderosis is related to siderosis and superficial siderosis of the central nervous system. An important gene associated with Superficial Siderosis is FTH1 (Ferritin, Heavy Polypeptide 1), and among its related pathways are Iron metabolism in placenta and HIF-1 signaling pathway. Affiliated tissues include brain, bone and spinal cord, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Related Diseases for Superficial Siderosis

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Graphical network of the top 20 diseases related to Superficial Siderosis:



Diseases related to superficial siderosis

Symptoms for Superficial Siderosis

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Drugs & Therapeutics for Superficial Siderosis

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Drugs for Superficial Siderosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
IronapprovedPhase 49577439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Dexiron
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
Ed-In-Sol
 
Eisen
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feraheme
Feronate
Ferretts
Ferrlecit
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Infufer
Iron
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Venofer
Vitedyn-Slo
Yieronia
fer
ferrous ascorbate
ferrous fumarate
ferrous gluconate
ferrous glycine sulfate
ferrous iron
ferrous succinate
ferrous sulfate
hierro
2
DeferiproneapprovedPhase 44930652-11-02972
Synonyms:
1,2-Dimethyl-3-hydroxypyrid-4-one
3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
APO-066
CP-20
DN-180-01-AF
Deferipron
 
Deferiprona
Deferiproni
Deferipronum
Deferypron
Dimethylhydroxypyridone
Défériprone
Ferriprox
PL-1

Interventional clinical trials:

idNameStatusNCT IDPhase
1Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial SiderosisActive, not recruitingNCT01284127Phase 4
2Superficial Siderosis in Patients With Suspected Cerebral Amyloid AngiopathyRecruitingNCT01856699
3Florbetaben as an Amyloid Plaque Marker in Elderly Patients With Focal or Disseminated Superficial HemosiderosisNot yet recruitingNCT02664571

Search NIH Clinical Center for Superficial Siderosis

Genetic Tests for Superficial Siderosis

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Anatomical Context for Superficial Siderosis

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MalaCards organs/tissues related to Superficial Siderosis:

33
Brain, Bone, Spinal cord, Testes, Bone marrow

Animal Models for Superficial Siderosis or affiliated genes

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MGI Mouse Phenotypes related to Superficial Siderosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6FTH1, HMOX1, LTF
2MP:00053978.0FTH1, HMOX1, LTF, TF
3MP:00053767.7FTH1, HMOX1, LTF, TF

Publications for Superficial Siderosis

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Articles related to Superficial Siderosis:

(show top 50)    (show all 255)
idTitleAuthorsYear
1
Cortical superficial siderosis, APOE genotype, and hemorrhage risk in cerebral amyloid angiopathy. (25716363)
2015
2
Bilateral Vestibulopathy Documented by Video Head Impulse Tests in Superficial Siderosis. (26440725)
2015
3
Superficial siderosis of the central nervous system associated with incomplete dural closure following posterior fossa surgery: report of 3 cases. (26067619)
2015
4
Time-resolved imaging of contrast kinetics imaging showing a vertebral hemangioma in CNS superficial siderosis. (25234095)
2014
5
Interrelationship of superficial siderosis and microbleeds in cerebral amyloid angiopathy. (25320098)
2014
6
CSF biomarkers in superficial siderosis: a new tool for diagnosis and evaluation of therapeutic efficacy of deferiprone--a case report. (24627229)
2014
7
Cerebral amyloid angiopathy: amyloid spells and cortical superficial siderosis. (25359331)
2014
8
High noon back pain- severe pseudoradicular pain as a lead symptom of superficial siderosis: a case report. (25371709)
2014
9
Superficial siderosis of the central nervous system presenting with dysuria initially. (24698546)
2014
10
Spinal intradural extramedullary cavernous angioma presenting with superficial siderosis and hydrocephalus: a case report and review of the literature. (25130126)
2014
11
Superficial siderosis of the central nervous system as a presentation of stage iv melanoma. (24856369)
2014
12
Superficial siderosis associated with aceruloplasminemia. Case report. (24607334)
2014
13
Teaching neuroImages: MRI changes in superficial siderosis. (22547776)
2012
14
Progression and management of superficial siderosis. (22342237)
2012
15
Superficial siderosis associated with multiple dural tears opening into a spinal epidural fluid collection. (21748941)
2011
16
A patient with superficial siderosis, intraspinal cyst, low-pressure headache and low-lying cord. (22368982)
2011
17
Superficial siderosis in cerebral amyloid angiopathy. (21654928)
2011
18
Superficial siderosis of the central nervous system: phenotype and implications for audiology and otology. (21730883)
2011
19
Superficial siderosis of the CNS. (21700976)
2011
20
Cochlear implantation in a patient with superficial siderosis: an update. (20015783)
2010
21
Superficial siderosis mimicking amyotrophic lateral sclerosis. (20215988)
2010
22
Superficial siderosis of the central nervous system manifested with seizures. (20006512)
2010
23
Intraventricular cavernous malformation with superficial siderosis. (20457968)
2010
24
Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy. (20975060)
2010
25
Iron localization in superficial siderosis of the central nervous system. (18694445)
2009
26
Cochlear implant patients with superficial siderosis. (19594083)
2009
27
Superficial siderosis: sealing the defect. (19221303)
2009
28
Cognitive impairment in superficial siderosis of the central nervous system: a case report. (18937022)
2009
29
Superficial siderosis revealed by isolated cognitive impairment. (19196635)
2009
30
Systemic sclerosis and superficial siderosis of the central nervous system: casuality or causality? (18193230)
2008
31
Cerebellar atrophy revealing superficial siderosis. (18795601)
2008
32
Cognitive and social impairments in patients with superficial siderosis. (15788543)
2005
33
MRI findings in a case of a superficial siderosis associated with an ependymoma. (12297737)
2002
34
Superficial siderosis from spinal teratoma. (12443590)
2002
35
Neuro-otologic findings in a case of superficial siderosis with bilateral hearing impairment. (11771051)
2001
36
Superficial siderosis of the central nervous system in a patient with neurofibromatosis type I. (10686476)
2000
37
Superficial siderosis of the central nervous system. A case report on examination by ECoG and DPOAE. (10965263)
2000
38
Evidence for preganglionic pupillary involvement in superficial siderosis. (10496281)
1999
39
Elevated CSF lactoferrin in superficial siderosis of the central nervous system. (10552243)
1999
40
Superficial siderosis of the central nervous system and anticoagulant therapy: a case report. (10551912)
1999
41
Secondary superficial siderosis of the central nervous system in a patient presenting with sensorineural hearing loss. (9638673)
1998
42
Neuroradiology case of the day. Myxopapillary ependymoma of the conus medullaris or filum terminale resulting in superficial siderosis and dissemination of tumor along CSF pathways. (9599402)
1998
43
Morphological and functional study of a case of superficial siderosis of the central nervous system. (9239533)
1997
44
Focal dystonia secondary to superficial siderosis. (8813232)
1996
45
Superficial siderosis of the brain: roles for cerebrospinal fluid circulation, iron and the hydroxyl radical. (8910872)
1996
46
Superficial siderosis of the central nervous system: a neglected cause of sensorineural hearing loss. (1528605)
1992
47
Superficial siderosis of the central nervous system. A 37-year follow-up of a case and review of the literature. (1832307)
1991
48
Superficial siderosis of the central nervous system. (2926762)
1989
49
High-field MR imaging of superficial siderosis of the central nervous system. (4031180)
1985
50
Superficial siderosis of the central nervous system. (5100703)
1971

Variations for Superficial Siderosis

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Expression for genes affiliated with Superficial Siderosis

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Search GEO for disease gene expression data for Superficial Siderosis.

Pathways for genes affiliated with Superficial Siderosis

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Pathways related to Superficial Siderosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4FTH1, TF
29.3HMOX1, TF
39.3HMOX1, TF
48.8FTH1, HMOX1, TF
5
Show member pathways
8.8FTH1, HMOX1, TF
6
Show member pathways
8.0FTH1, HMOX1, LTF, TF

GO Terms for genes affiliated with Superficial Siderosis

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Cellular components related to Superficial Siderosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.5HMOX1, LTF, TF

Biological processes related to Superficial Siderosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1iron ion transportGO:000682610.0FTH1, TF
2iron ion homeostasisGO:00550729.9HMOX1, TF
3positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.1HMOX1, LTF
4retina homeostasisGO:00018959.1LTF, TF
5cellular iron ion homeostasisGO:00068798.7FTH1, HMOX1, TF
6transmembrane transportGO:00550858.5FTH1, HMOX1, TF

Molecular functions related to Superficial Siderosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ferric iron bindingGO:00081999.8FTH1, TF
2iron ion bindingGO:00055069.1FTH1, LTF

Sources for Superficial Siderosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet