MCID: SPR007
MIFTS: 40

Superior Mesenteric Artery Syndrome

Categories: Rare diseases, Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Superior Mesenteric Artery Syndrome

MalaCards integrated aliases for Superior Mesenteric Artery Syndrome:

Name: Superior Mesenteric Artery Syndrome 12 50 42 14 69
Arteriomesenteric Compression of Duodenojejunal Flexure 69
Arteriomesenteric Duodenal Compression Syndrome 50
Vascular Compression of the Duodenum 50
Wilkie Syndrome 50
Cast Syndrome 50

Classifications:



External Ids:

Disease Ontology 12 DOID:3557
MeSH 42 D013478
NCIt 47 C85175
SNOMED-CT 64 197006009 24988007
UMLS 69 C0038828

Summaries for Superior Mesenteric Artery Syndrome

NIH Rare Diseases : 50 superior mesenteric artery syndrome (smas) is a digestive condition that occurs when the duodenum (the first part of the small intestine) is compressed between two arteries (the aorta and the superior mesenteric artery). this compression causes partial or complete blockage of the duodenum. symptoms vary based on severity, but can be severely debilitating. symptoms may include abdominal pain, fullness, nausea, vomiting, and/or weight loss. smas typically is due to loss of the mesenteric fat pad (fatty tissue that surrounds the superior mesenteric artery). the most common cause is significant weight loss caused by medical disorders, psychological disorders, or surgery. in younger patients, it most commonly occurs after corrective spinal surgery for scoliosis. delays in diagnosis may result in significant complications. depending on the cause and severity, treatment options may include addressing the underlying cause, dietary changes (small feedings or a liquid diet), and/or surgery. symptoms may not resolve completely after treatment. last updated: 7/6/2017

MalaCards based summary : Superior Mesenteric Artery Syndrome, also known as arteriomesenteric compression of duodenojejunal flexure, is related to renal nutcracker syndrome and situs inversus, and has symptoms including abdominal angina An important gene associated with Superior Mesenteric Artery Syndrome is KRT17 (Keratin 17), and among its related pathways/superpathways are O-linked glycosylation and Diseases of glycosylation. Affiliated tissues include small intestine, brain and spinal cord, and related phenotype is digestive/alimentary.

Wikipedia : 72 Superior mesenteric artery (SMA) syndrome is a gastro-vascular disorder in which the third and final... more...

Related Diseases for Superior Mesenteric Artery Syndrome

Diseases related to Superior Mesenteric Artery Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 183)
id Related Disease Score Top Affiliating Genes
1 renal nutcracker syndrome 11.1
2 situs inversus 10.7 MUC2 MUC6
3 urinary system disease 10.7 MUC2 MUC6
4 cushing's syndrome 10.6 ATP4A CDX2
5 breast mucinous cystadenocarcinoma 10.6 CDX2 MUC2
6 tubular adenocarcinoma 10.6 CDX2 MUC2
7 cholangitis 10.6 CDX2 MUC2
8 scrotum melanoma 10.5 ATP12A ATP4A
9 congenital aphakia 10.5 ATP12A ATP4A
10 shwartzman phenomenon 10.5 ATP12A ATP4A
11 anemia of prematurity 10.5 CDX2 MUC2
12 primary syphilis 10.5 ATP12A ATP4A
13 bone giant cell sarcoma 10.5 ATP12A ATP4A
14 urethral calculus 10.5 ATP12A ATP4A
15 breast ductal adenoma 10.5 ATP12A ATP4A
16 hypopituitarism 10.5 ATP12A ATP4A
17 amyotrophic lateral sclerosis type 5 10.5 ATP12A ATP4A
18 hyperimmunoglobulin syndrome 10.5 AVP HTR3A
19 stricture or kinking of ureter 10.5 CDX2 KRT17 MUC2
20 atheroembolism of kidney 10.5 ATP12A ATP4A
21 microphthalmia, syndromic 12 10.5 ATP12A ATP4A
22 synovitis 10.5 CDX2 CEACAM5
23 muscle cancer 10.5 ATP12A ATP4A
24 adult xanthogranuloma 10.4 ATP12A ATP4A
25 migraine with aura 10.4 CDX2 MUC2 MUC6
26 pacinian tumor 10.4 CDX2 MUC2 MUC6
27 focal hand dystonia 10.4 ATP12A ATP4A
28 pancreatic signet ring cell adenocarcinoma 10.4 CDX2 MUC2 MUC6
29 optic papillitis 10.4 CDX2 MUC2 MUC6
30 cloacal exstrophy 10.4 ATP12A ATP4A
31 pineal region meningioma 10.4 CDX2 CEACAM5
32 intrahepatic cholangiocarcinoma 10.4 CDX2 CEACAM5
33 spastic ataxia 3 10.4 CDX2 MUC6
34 giant cell tumor 10.4 CDX2 CEACAM5
35 thrombocytopenia due to platelet alloimmunization 10.4 ATP12A ATP4A
36 myotonia congenita 10.4 CDX2 CEACAM5
37 proliferative fasciitis 10.4 ATP12A ATP4A
38 hodgkin's paragranuloma 10.4 ATP12A ATP4A
39 spinocerebellar ataxia 18 10.4 ATP12A ATP4A
40 duodenitis 10.4
41 cystic basal cell carcinoma 10.3 CEACAM5 KRT17
42 idiopathic central precocious puberty 10.3 MUC2 MUC5AC
43 scoliosis 10.3
44 fungal gastritis 10.3 ATP12A ATP4A
45 cubitus valgus with mental retardation and unusual facies 10.3 ATP12A ATP4A
46 synostosis 10.3 ATP12A ATP4A PMAIP1
47 abnormal pupillary function 10.3 ATP12A ATP4A HTR3A
48 ileocolitis 10.3 ATP12A ATP4A
49 scleral staphyloma 10.2 ATP12A ATP4A HTR3A
50 allergic urticaria 10.2 ATP12A ATP4A

Graphical network of the top 20 diseases related to Superior Mesenteric Artery Syndrome:



Diseases related to Superior Mesenteric Artery Syndrome

Symptoms & Phenotypes for Superior Mesenteric Artery Syndrome

UMLS symptoms related to Superior Mesenteric Artery Syndrome:


abdominal angina

MGI Mouse Phenotypes related to Superior Mesenteric Artery Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.23 ATP12A ATP4A CDX2 KRT17 KRT19 MUC2

Drugs & Therapeutics for Superior Mesenteric Artery Syndrome

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Evaluation of Portal Venous System Thrombosis After Blunt Splenic Trauma Utilizing Doppler Ultrasound Unknown status NCT01906983
2 Impact of Different Modes of Noninvasive Ventilation on Regional Oximetry and Hemodynamics in Premature Newborn Completed NCT01942967
3 Perioperative Intra-Aortic Balloon Pump (IABP) in Coronary Artery Bypass Grafting (CABG) Operations in Patients With Severely Depressed Left Ventricular Function Completed NCT00881192
4 Aneurysmal Subarachnoid Hemorrhage and Superior Mesenteric Artery Flow Study Terminated NCT02684500

Search NIH Clinical Center for Superior Mesenteric Artery Syndrome

Cochrane evidence based reviews: superior mesenteric artery syndrome

Genetic Tests for Superior Mesenteric Artery Syndrome

Anatomical Context for Superior Mesenteric Artery Syndrome

MalaCards organs/tissues related to Superior Mesenteric Artery Syndrome:

39
Small Intestine, Brain, Spinal Cord, Testes, B Cells, Pancreas, Colon

Publications for Superior Mesenteric Artery Syndrome

Articles related to Superior Mesenteric Artery Syndrome:

(show top 50) (show all 371)
id Title Authors Year
1
Superior Mesenteric Artery Syndrome: Weight Loss Can Be a Problem, Weight Gain Can Be a Solution. ( 28848779 )
2017
2
Superior mesenteric artery syndrome in a young woman. ( 28270402 )
2017
3
Superior mesenteric artery syndrome: A rare but life threatening disease. ( 28616620 )
2017
4
Superior mesenteric artery syndrome: A diagnosis to be kept in mind (Case report and literature review). ( 28376419 )
2017
5
Superior Mesenteric Artery Syndrome May Be Overlooked in Women with Functional Dyspepsia. ( 28883239 )
2017
6
Superior mesenteric artery syndrome after lung transplantation: a rare early gastrointestinal complication of lung transplantation. ( 28364397 )
2017
7
Wilkie Syndrome behind Crohn Disease? Superior Mesenteric Artery Syndrome Mimicking and Complicating Crohn Disease of the Upper Gastrointestinal Tract. ( 28848781 )
2017
8
Unusual Mechanism for Superior Mesenteric Artery Syndrome after Scoliosis Surgery. ( 28759898 )
2017
9
Superior Mesenteric Artery Syndrome as a Complication of Scoliosis Surgery. ( 28437498 )
2017
10
Superior Mesenteric Artery Syndrome Associated with Abdominal Aortic Aneurysm. ( 28256350 )
2017
11
Superior mesenteric artery syndrome: an uncommon cause of intestinal obstruction. ( 28100055 )
2017
12
Superior mesenteric artery syndrome: a single centre experience of laparoscopic duodenojejunostomy as the operation of choice. ( 28660836 )
2017
13
Significant gastric distension caused by superior mesenteric artery syndrome or Wilkie's syndrome. ( 28434785 )
2017
14
Superior mesenteric artery syndrome in a healthy adolescent. ( 28637846 )
2017
15
Increase body weight to treat superior mesenteric artery syndrome. ( 28576908 )
2017
16
Intestinal atresia following chemotherapy, presenting as superior mesenteric artery syndrome: A case report. ( 28855988 )
2017
17
Unusual delayed presentation of superior mesenteric artery syndrome following scoliosis correction surgery-a case report and review of literature. ( 28744512 )
2017
18
Superior Mesenteric Artery Syndrome in association with Abdominal Tuberculosis: An Eye Opener. ( 28814938 )
2017
19
A Case Series of Laparoscopic Duodenojejunostomy for the Treatment of Pediatric Superior Mesenteric Artery Syndrome. ( 27747293 )
2016
20
Superior Mesenteric Artery Syndrome Complicated by Diabetic Ketoacidosis and Graves' Disease in Slowly Progressive Insulin Dependent Diabetes Mellitus (SPIDDM): A Case Report and a Review of the Literature. ( 27477411 )
2016
21
Laparoscopic duodenojejunostomy for superior mesenteric artery syndrome: intermediate follow-up results and a review of the literature. ( 27405482 )
2016
22
Superior Mesenteric Artery Syndrome Presented with Parkinson's Disease. ( 27523019 )
2016
23
Anemia revealing a rare association: superior mesenteric artery syndrome and nutcracker syndrome. ( 27532538 )
2016
24
Severe malnutrition causing superior mesenteric artery syndrome in an adolescent with Triple A syndrome. ( 27682707 )
2016
25
Superior Mesenteric Artery Syndrome: A Case Report of Two Surgical Options, Duodenal Derotation and Duodenojejunostomy. ( 28101395 )
2016
26
Superior mesenteric artery syndrome as a cause of acute pancreatitis. ( 27646321 )
2016
27
Superior Mesenteric Artery Syndrome: Diagnosis and Management. ( 28814697 )
2016
28
Unusual Manifestation of Superior Mesenteric Artery Syndrome in a Female Patient: A Case Presentation. ( 27833827 )
2016
29
Familial superior mesenteric artery syndrome. ( 27126095 )
2016
30
Laparoscopic Duodenojejunostomy for Superior Mesenteric Artery Syndrome. ( 27457852 )
2016
31
Superior Mesenteric Artery Syndrome Treated with Percutaneous Radiologic Gastrojejunostomy. ( 27312833 )
2016
32
Favorable minimal invasive surgery in the treatment of superior mesenteric artery syndrome: Case report. ( 27914348 )
2016
33
Primary adenocarcinoma of the small intestine presenting as superior mesenteric artery syndrome: A case report. ( 26998097 )
2016
34
A Rare Case of Gastric Mantle Cell Lymphoma causing Superior Mesenteric Artery Syndrome in an Adult. ( 28031660 )
2016
35
Conservative therapy for superior mesenteric artery syndrome. ( 26620963 )
2016
36
Superior Mesenteric Artery Syndrome with Abdominal Compartment Syndrome. ( 28003918 )
2016
37
Superior mesenteric artery syndrome: CT findings. ( 27353179 )
2016
38
Acute abdominal pain caused by superior mesenteric artery syndrome in a healthy young boy. ( 27993824 )
2016
39
Malroatation of gut with superior mesenteric artery syndrome and multiple jejunal diverticula presenting as acute intestinal obstruction in 6th decade: A rare case report. ( 25485845 )
2015
40
Superior Mesenteric Artery Syndrome in a 20-year-old Athletic Female with Abdominal Pain. ( 26612308 )
2015
41
Superior mesenteric artery syndrome as a cause for recurrent abdominal pain and vomiting in a 9-year-old girl. ( 25721841 )
2015
42
Image of the month: A Rare Case of Superior Mesenteric Artery Syndrome Causing Upper Gastrointestinal Bleeding. ( 26673491 )
2015
43
Superior mesenteric artery syndrome. ( 26035775 )
2015
44
Duodenal Emphysema Complicated with Superior Mesenteric Artery Syndrome in a Patient with Cerebral Paralysis: A Case Report. ( 26150182 )
2015
45
A Case of Superior Mesenteric Artery Syndrome in a Healthy Active Duty Marine. ( 26444481 )
2015
46
Massive gastrointestinal pneumatosis in a patient with celiac disease and superior mesenteric artery syndrome. ( 26468931 )
2015
47
Minimally invasive surgery for superior mesenteric artery syndrome: A case report. ( 26668518 )
2015
48
Massive gastrointestinal pneumatosis in a patient with celiac disease and superior mesenteric artery syndrome. ( 26541666 )
2015
49
Superior mesenteric artery syndrome after ileal pouch-anal anastomosis for colon cancer associated with ulcerative colitis: report of a case. ( 26943395 )
2015
50
A Model Example: Coexisting Superior Mesenteric Artery Syndrome and the Nutcracker Phenomenon. ( 26448895 )
2015

Variations for Superior Mesenteric Artery Syndrome

Expression for Superior Mesenteric Artery Syndrome

Search GEO for disease gene expression data for Superior Mesenteric Artery Syndrome.

Pathways for Superior Mesenteric Artery Syndrome

GO Terms for Superior Mesenteric Artery Syndrome

Cellular components related to Superior Mesenteric Artery Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.8 MUC2 MUC5AC MUC6

Biological processes related to Superior Mesenteric Artery Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.43 MUC2 MUC5AC MUC6
2 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP12A ATP4A
3 maintenance of gastrointestinal epithelium GO:0030277 8.96 MUC2 MUC6
4 O-glycan processing GO:0016266 8.8 MUC2 MUC5AC MUC6

Molecular functions related to Superior Mesenteric Artery Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 hydrogen:potassium-exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Superior Mesenteric Artery Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
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55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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