MCID: SPR007
MIFTS: 42

Superior Mesenteric Artery Syndrome

Categories: Rare diseases, Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Superior Mesenteric Artery Syndrome

MalaCards integrated aliases for Superior Mesenteric Artery Syndrome:

Name: Superior Mesenteric Artery Syndrome 12 72 49 41 14 69
Arteriomesenteric Compression of Duodenojejunal Flexure 69
Arteriomesenteric Duodenal Compression Syndrome 49
Vascular Compression of the Duodenum 49
Wilkie Syndrome 49
Cast Syndrome 49

Classifications:



External Ids:

Disease Ontology 12 DOID:3557
MeSH 41 D013478
NCIt 46 C85175
SNOMED-CT 64 197006009 24988007

Summaries for Superior Mesenteric Artery Syndrome

NIH Rare Diseases : 49 Superior mesenteric artery syndrome (SMAS) is a digestive condition that occurs when the duodenum (the first part of the small intestine) is compressed between two arteries (the aorta and the superior mesenteric artery). This compression causes partial or complete blockage of the duodenum. Symptoms vary based on severity, but can be severely debilitating. Symptoms may include abdominal pain, fullness, nausea, vomiting, and/or weight loss. SMAS typically is due to loss of the mesenteric fat pad (fatty tissue that surrounds the superior mesenteric artery). The most common cause is significant weight loss caused by medical disorders, psychological disorders, or surgery. In younger patients, it most commonly occurs after corrective spinal surgery for scoliosis. Delays in diagnosis may result in significant complications. Depending on the cause and severity, treatment options may include addressing the underlying cause, dietary changes (small feedings or a liquid diet), and/or surgery. Symptoms may not resolve completely after treatment. Last updated: 7/6/2017

MalaCards based summary : Superior Mesenteric Artery Syndrome, also known as arteriomesenteric compression of duodenojejunal flexure, is related to duodenitis and hernia, hiatus, and has symptoms including abdominal angina An important gene associated with Superior Mesenteric Artery Syndrome is KRT17 (Keratin 17), and among its related pathways/superpathways are Diseases of glycosylation and Defective GALNT12 causes colorectal cancer 1 (CRCS1). Affiliated tissues include small intestine, brain and spinal cord, and related phenotype is digestive/alimentary.

Wikipedia : 72 Superior mesenteric artery (SMA) syndrome is a gastro-vascular disorder in which the third and final... more...

Related Diseases for Superior Mesenteric Artery Syndrome

Diseases related to Superior Mesenteric Artery Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
# Related Disease Score Top Affiliating Genes
1 duodenitis 31.3 ATP12A ATP4A
2 hernia, hiatus 30.3 ATP12A ATP4A
3 renal nutcracker syndrome 11.5
4 fungal esophagitis 10.5 ATP12A ATP4A
5 gastrointestinal neuroendocrine benign tumor 10.5 ATP12A ATP4A
6 gastric neuroendocrine neoplasm 10.5 ATP12A ATP4A
7 neonatal candidiasis 10.5 ATP12A ATP4A
8 pancreatic intraductal papillary-mucinous neoplasm 10.5 MUC2 MUC6
9 photoallergic dermatitis 10.5 ATP12A ATP4A
10 squamous papillomatosis 10.5 ATP12A ATP4A
11 acute laryngitis 10.5 ATP12A ATP4A
12 tumor of exocrine pancreas 10.5 MUC2 MUC6
13 gastroduodenal crohn's disease 10.5 ATP12A ATP4A
14 toxic megacolon 10.5 ATP12A ATP4A
15 aspiration pneumonitis 10.5 ATP12A ATP4A
16 gastric antral vascular ectasia 10.5 ATP12A ATP4A
17 esophageal candidiasis 10.5 ATP12A ATP4A
18 postsurgical hypothyroidism 10.5 ATP12A ATP4A
19 laryngeal disease 10.5 ATP12A ATP4A
20 congenital disorder of deglycosylation 10.5 ATP12A ATP4A
21 granulomatous gastritis 10.5 ATP12A ATP4A
22 active peptic ulcer disease 10.5 ATP12A ATP4A
23 dyskinesia of esophagus 10.4 ATP12A ATP4A
24 anismus 10.4 ATP12A ATP4A
25 capillary disease 10.4 ATP12A ATP4A
26 peptic esophagitis 10.4 ATP12A ATP4A
27 duodenal disease 10.4 ATP12A ATP4A
28 esophageal atresia/tracheoesophageal fistula 10.4 ATP12A ATP4A
29 laryngitis 10.4 ATP12A ATP4A
30 laryngeal tuberculosis 10.4 ATP12A ATP4A
31 scoliosis 10.4
32 lymphocytic colitis 10.4 ATP12A ATP4A
33 chronic intestinal vascular insufficiency 10.4 ATP12A ATP4A
34 sphenoid sinusitis 10.4 AVP PGRMC1
35 clostridium difficile colitis 10.4 ATP12A ATP4A
36 diarrhea 1, secretory chloride, congenital 10.4 ATP12A ATP4A
37 chronic cholangitis 10.4 CDX2 MUC2
38 aspiration pneumonia 10.4 ATP12A ATP4A
39 ovarian mucinous adenocarcinoma 10.4 CDX2 MUC2
40 esophageal varix 10.3 ATP12A ATP4A
41 eosinophilic gastritis 10.3 ATP12A ATP4A
42 bladder calculus 10.3 ATP12A ATP4A PGRMC1
43 lower urinary tract calculus 10.3 ATP12A ATP4A PGRMC1
44 ischemic neuropathy 10.3 ATP12A ATP4A PMAIP1
45 endocervical adenocarcinoma 10.3 CDX2 MUC6
46 myopathy, x-linked, with excessive autophagy 10.3 ATP12A ATP4A
47 rumination disorder 10.3 ATP12A ATP4A HTR3A
48 motion sickness 10.3 AVP HTR3A
49 functional gastric disease 10.3 ATP12A ATP4A HTR3A
50 chronic dacryocystitis 10.3 PGRMC1 WDFY2

Graphical network of the top 20 diseases related to Superior Mesenteric Artery Syndrome:



Diseases related to Superior Mesenteric Artery Syndrome

Symptoms & Phenotypes for Superior Mesenteric Artery Syndrome

UMLS symptoms related to Superior Mesenteric Artery Syndrome:


abdominal angina

MGI Mouse Phenotypes related to Superior Mesenteric Artery Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.23 ATP12A ATP4A CDX2 KRT17 KRT19 MUC2

Drugs & Therapeutics for Superior Mesenteric Artery Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 SMAS: a Prospective Study in a Single Institution Completed NCT03416647

Search NIH Clinical Center for Superior Mesenteric Artery Syndrome

Cochrane evidence based reviews: superior mesenteric artery syndrome

Genetic Tests for Superior Mesenteric Artery Syndrome

Anatomical Context for Superior Mesenteric Artery Syndrome

MalaCards organs/tissues related to Superior Mesenteric Artery Syndrome:

38
Small Intestine, Brain, Spinal Cord, Testes, B Cells, Pancreas, Colon

Publications for Superior Mesenteric Artery Syndrome

Articles related to Superior Mesenteric Artery Syndrome:

(show top 50) (show all 386)
# Title Authors Year
1
Superior Mesenteric Artery Syndrome: An Uncommon Cause of Abdominal Pain. ( 29336988 )
2018
2
Robotic Strong's procedure for the treatment of superior mesenteric artery syndrome. Description of surgical technique on occasion of the first reported case in the literature. ( 29168288 )
2018
3
Superior mesenteric artery syndrome: quality of life after laparoscopic duodenojejunostomy. ( 29445471 )
2018
4
A Rare Case of Coexisting Superior Mesenteric Artery Syndrome and Nutcracker Phenomenon. ( 29062567 )
2017
5
Clinical and Radiologic Considerations for Idiopathic Superior Mesenteric Artery Syndrome. ( 29321946 )
2017
6
Superior Mesenteric Artery Syndrome in association with Abdominal Tuberculosis: An Eye Opener. ( 28814938 )
2017
7
Superior Mesenteric Artery Syndrome: Weight Loss Can Be a Problem, Weight Gain Can Be a Solution. ( 28848779 )
2017
8
Superior Mesenteric Artery Syndrome Combined with Renal Nutcracker Syndrome in a Young Male: A Case Report. ( 29277094 )
2017
9
Intestinal atresia following chemotherapy, presenting as superior mesenteric artery syndrome: A case report. ( 28855988 )
2017
10
Superior mesenteric artery syndrome after lung transplantation: a rare early gastrointestinal complication of lung transplantation. ( 28364397 )
2017
11
The two sides of superior mesenteric artery syndrome treatment: conservative or surgical management? ( 29095027 )
2017
12
Superior mesenteric artery syndrome in a young woman. ( 28270402 )
2017
13
Wilkie Syndrome behind Crohn Disease? Superior Mesenteric Artery Syndrome Mimicking and Complicating Crohn Disease of the Upper Gastrointestinal Tract. ( 28848781 )
2017
14
A Case Series on Superior Mesenteric Artery Syndrome Surgical Management, Single Institution Experience. ( 28969208 )
2017
15
Superior mesenteric artery syndrome leading to reversible mucosal gangrene. ( 29123896 )
2017
16
Anorexia nervosa complicated with hiatal hernia and superior mesenteric artery syndrome: A case illustrating the risk of inference observation confusion. ( 29264011 )
2017
17
Superior mesenteric artery syndrome: an uncommon cause of intestinal obstruction. ( 28100055 )
2017
18
Superior Mesenteric Artery Syndrome Combined with Renal Nutcracker Syndrome in a Young Male: A Case Report. ( 29161795 )
2017
19
Superior Mesenteric Artery Syndrome after Kyphosis Correction - A Case Report. ( 29242799 )
2017
20
Superior Mesenteric Artery Syndrome as a Complication of Scoliosis Surgery. ( 28437498 )
2017
21
Superior mesenteric artery syndrome in a healthy adolescent. ( 28637846 )
2017
22
Superior Mesenteric Artery Syndrome Improved by Enteral Nutritional Therapy according to the Controlling Nutritional Status Score. ( 29430225 )
2017
23
Increase body weight to treat superior mesenteric artery syndrome. ( 28576908 )
2017
24
Unusual Mechanism for Superior Mesenteric Artery Syndrome after Scoliosis Surgery. ( 28759898 )
2017
25
Superior mesenteric artery syndrome: A diagnosis to be kept in mind (Case report and literature review). ( 28376419 )
2017
26
Superior Mesenteric Artery Syndrome: The Dark Side of Weight Loss. ( 29375945 )
2017
27
Superior Mesenteric Artery Syndrome May Be Overlooked in Women with Functional Dyspepsia. ( 28883239 )
2017
28
Superior mesenteric artery syndrome: a single centre experience of laparoscopic duodenojejunostomy as the operation of choice. ( 28660836 )
2017
29
Unusual delayed presentation of superior mesenteric artery syndrome following scoliosis correction surgery-a case report and review of literature. ( 28744512 )
2017
30
Superior mesenteric artery syndrome: A rare but life threatening disease. ( 28616620 )
2017
31
Significant gastric distension caused by superior mesenteric artery syndrome or Wilkie's syndrome. ( 28434785 )
2017
32
Superior Mesenteric Artery Syndrome Associated with Abdominal Aortic Aneurysm. ( 28256350 )
2017
33
Unusual Manifestation of Superior Mesenteric Artery Syndrome in a Female Patient: A Case Presentation. ( 27833827 )
2016
34
Superior Mesenteric Artery Syndrome: Diagnosis and Management. ( 28814697 )
2016
35
Severe malnutrition causing superior mesenteric artery syndrome in an adolescent with Triple A syndrome. ( 27682707 )
2016
36
Conservative therapy for superior mesenteric artery syndrome. ( 26620963 )
2016
37
Laparoscopic duodenojejunostomy for superior mesenteric artery syndrome: intermediate follow-up results and a review of the literature. ( 27405482 )
2016
38
Favorable minimal invasive surgery in the treatment of superior mesenteric artery syndrome: Case report. ( 27914348 )
2016
39
Superior Mesenteric Artery Syndrome Complicated by Diabetic Ketoacidosis and Graves' Disease in Slowly Progressive Insulin Dependent Diabetes Mellitus (SPIDDM): A Case Report and a Review of the Literature. ( 27477411 )
2016
40
Familial superior mesenteric artery syndrome. ( 27126095 )
2016
41
A Case Series of Laparoscopic Duodenojejunostomy for the Treatment of Pediatric Superior Mesenteric Artery Syndrome. ( 27747293 )
2016
42
Superior Mesenteric Artery Syndrome Presented with Parkinson's Disease. ( 27523019 )
2016
43
Superior mesenteric artery syndrome: CT findings. ( 27353179 )
2016
44
Primary adenocarcinoma of the small intestine presenting as superior mesenteric artery syndrome: A case report. ( 26998097 )
2016
45
Superior Mesenteric Artery Syndrome Treated with Percutaneous Radiologic Gastrojejunostomy. ( 27312833 )
2016
46
Superior Mesenteric Artery Syndrome: A Case Report of Two Surgical Options, Duodenal Derotation and Duodenojejunostomy. ( 28101395 )
2016
47
Anemia revealing a rare association: superior mesenteric artery syndrome and nutcracker syndrome. ( 27532538 )
2016
48
Acute abdominal pain caused by superior mesenteric artery syndrome in a healthy young boy. ( 27993824 )
2016
49
Superior mesenteric artery syndrome as a cause of acute pancreatitis. ( 27646321 )
2016
50
A Rare Case of Gastric Mantle Cell Lymphoma causing Superior Mesenteric Artery Syndrome in an Adult. ( 28031660 )
2016

Variations for Superior Mesenteric Artery Syndrome

Expression for Superior Mesenteric Artery Syndrome

Search GEO for disease gene expression data for Superior Mesenteric Artery Syndrome.

Pathways for Superior Mesenteric Artery Syndrome

GO Terms for Superior Mesenteric Artery Syndrome

Cellular components related to Superior Mesenteric Artery Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.8 MUC2 MUC5AC MUC6

Biological processes related to Superior Mesenteric Artery Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.43 MUC2 MUC5AC MUC6
2 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP12A ATP4A
3 maintenance of gastrointestinal epithelium GO:0030277 8.96 MUC2 MUC6
4 O-glycan processing GO:0016266 8.8 MUC2 MUC5AC MUC6

Molecular functions related to Superior Mesenteric Artery Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 hydrogen:potassium-exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Superior Mesenteric Artery Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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