MCID: SPP008
MIFTS: 50

Suppurative Otitis Media

Categories: Ear diseases

Aliases & Classifications for Suppurative Otitis Media

MalaCards integrated aliases for Suppurative Otitis Media:

Name: Suppurative Otitis Media 12 14 69
Otitis Media with Effusion - Purulent 12
Otitis Media, Suppurative 41
Purulent Otitis Media 12

Classifications:



Summaries for Suppurative Otitis Media

Disease Ontology : 12 A otitis media which involves inflammation of the middle ear with infected effusion containing pus.

MalaCards based summary : Suppurative Otitis Media, also known as otitis media with effusion - purulent, is related to chronic purulent otitis media and otitis media. An important gene associated with Suppurative Otitis Media is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and NF-KappaB Family Pathway. The drugs Acetylcysteine and Ciprofloxacin have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and testes, and related phenotypes are hematopoietic system and immune system

Related Diseases for Suppurative Otitis Media

Diseases related to Suppurative Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 chronic purulent otitis media 33.3 HSF4 WIPF1
2 otitis media 33.0 IL1B TLR2 TLR4
3 mastoiditis 30.7 CRP SLC29A3
4 meningitis 30.5 CRP IL1B TLR2
5 mesenteric lymphadenitis 30.2 CRP TLR2
6 lymphadenitis 30.1 IL1B TLR4
7 appendicitis 30.0 CRP IL1B
8 bacterial meningitis 29.9 CRP IL1B TLR2
9 pneumonia 29.0 CRP IL1B TLR2 TLR4 TLR5
10 chronic tubotympanic suppurative otitis media 12.7
11 non-suppurative otitis media 12.5
12 purulent acute otitis media 12.3
13 chronic atticoantral disease 11.8
14 serous glue ear 11.4
15 acute serous otitis media 11.3
16 focal labyrinthitis 11.3
17 eustachian tube disease 11.3
18 cholesteatoma 10.6
19 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.5
20 trench fever 10.4 TLR2 TLR4
21 acute cervicitis 10.4 TLR2 TLR4
22 penicilliosis 10.4 TLR2 TLR4
23 myositis fibrosa 10.4 TLR2 TLR4
24 alveolar echinococcosis 10.4 TLR2 TLR4
25 campylobacteriosis 10.4 IL1B TLR4
26 periodontitis, chronic 10.4 IL1B TLR2
27 neisseria meningitidis infection 10.3 TLR2 TLR4
28 endometrial disease 10.3 IL1B TLR4
29 haemophilus influenzae 10.3 IL1B TLR2
30 cysticercosis 10.3 IL1B TLR4
31 periapical periodontitis 10.3 IL1B TLR2
32 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.3
33 thrombosis 10.3
34 sensorineural hearing loss 10.3
35 invasive aspergillosis 10.3 TLR2 TLR4
36 legionnaires' disease 10.3 TLR4 TLR5
37 paracoccidioidomycosis 10.3 TLR2 TLR4
38 labyrinthitis 10.3
39 dental abscess 10.3 CRP TLR4
40 keratoconjunctivitis sicca 10.3 IL1B TLR4
41 extrapulmonary tuberculosis 10.3 IL1B TLR2
42 idiopathic neutropenia 10.3 IL1B TLR4
43 pyelitis 10.2 CRP TLR4
44 branchiootic syndrome 1 10.2
45 mycobacterium tuberculosis 1 10.2
46 mucositis 10.2
47 uremic pruritus 10.2 CRP IL1B
48 pericoronitis 10.2 CRP IL1B
49 filariasis 10.2 TLR2 TLR4
50 salmonellosis 10.2 IL1B TLR4

Graphical network of the top 20 diseases related to Suppurative Otitis Media:



Diseases related to Suppurative Otitis Media

Symptoms & Phenotypes for Suppurative Otitis Media

MGI Mouse Phenotypes related to Suppurative Otitis Media:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.63 IL1B SLC29A3 TLR2 TLR4 TLR5 WIPF1
2 immune system MP:0005387 9.5 SLC29A3 TLR2 TLR4 TLR5 WIPF1 CRP
3 neoplasm MP:0002006 8.92 IL1B SLC29A3 TLR2 TLR4

Drugs & Therapeutics for Suppurative Otitis Media

Drugs for Suppurative Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
2
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4 Anti-Bacterial Agents Phase 4,Phase 1
5 Anti-Infective Agents Phase 4,Phase 1
6 Topoisomerase Inhibitors Phase 4,Phase 1
7 Cytochrome P-450 Enzyme Inhibitors Phase 4
8 Antidotes Phase 4
9 Antiemetics Phase 4
10 Anti-Inflammatory Agents Phase 4
11 Antineoplastic Agents, Hormonal Phase 4
12 Antioxidants Phase 4
13 Antiviral Agents Phase 4
14 Autonomic Agents Phase 4
15 BB 1101 Phase 4
16 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
17 Dexamethasone acetate Phase 4 1177-87-3
18 Expectorants Phase 4
19 Gastrointestinal Agents Phase 4
20 glucocorticoids Phase 4
21 HIV Protease Inhibitors Phase 4
22 Hormone Antagonists Phase 4
23 Hormones Phase 4
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
25 N-monoacetylcystine Phase 4
26 Peripheral Nervous System Agents Phase 4
27 Pharmaceutical Solutions Phase 4
28
protease inhibitors Phase 4
29 Protective Agents Phase 4
30 Respiratory System Agents Phase 4
31 Pazufloxacin Investigational Phase 1 127045-41-4
32 Antitubercular Agents Phase 1
33 Fluoroquinolones Phase 1
34 Nucleic Acid Synthesis Inhibitors Phase 1
35
Sulfamethoxazole Approved 723-46-6 5329
36
Trimethoprim Approved, Vet_approved 738-70-5 5578
37
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
38
leucovorin Approved, Nutraceutical 58-05-9 143 6006
39 Antimalarials
40 Antiparasitic Agents
41 Antiprotozoal Agents
42 Folic Acid Antagonists
43 Renal Agents
44 Trimethoprim, Sulfamethoxazole Drug Combination
45 Vitamin B Complex
46 Folate Nutraceutical
47 Vitamin B9 Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Not yet recruiting NCT00956748 Phase 4 Ciprodex;Ciprodex and 2% NAC
2 A Comparative Study of the Outcomes of 2 Surgical Procedures for Safe Type of Chronic Otitis Media Unknown status NCT00271778 Phase 3
3 Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol Unknown status NCT02592096 Phase 1 0.1% Pazufloxacin Mesilate Ear Drops;0.3% Pazufloxacin Mesilate Ear Drops;0.5% Pazufloxacin Mesilate Ear Drops;Pazufloxacin mesilate injection
4 Host-pathogen Interaction in Otitis Media Unknown status NCT00847756
5 Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media Completed NCT00189098 Sulfamethoxazole-trimethoprim;Placebo
6 Prevalence and Associations of Paediatric Chronic Suppurative Otitis Media and Hearing Impairment in Rural Malawi Recruiting NCT02779907
7 Evaluation of Prognostic Factors in Tympanoplasty Not yet recruiting NCT03416725
8 Treatment and Prevention of Middle Ear Morbidity in Head and Neck Cancer Patients Following Radiotherapy Not yet recruiting NCT02716376

Search NIH Clinical Center for Suppurative Otitis Media

Cochrane evidence based reviews: otitis media, suppurative

Genetic Tests for Suppurative Otitis Media

Anatomical Context for Suppurative Otitis Media

MalaCards organs/tissues related to Suppurative Otitis Media:

38
Brain, Bone, Testes, Neutrophil, Temporal Lobe, T Cells

Publications for Suppurative Otitis Media

Articles related to Suppurative Otitis Media:

(show top 50) (show all 566)
# Title Authors Year
1
Efficacy of Boric Acid as a Treatment of Choice for Chronic Suppurative Otitis Media and Its Ototoxicity. ( 29383205 )
2018
2
A study of bacterial pathogens and antibiotic susceptibility patterns in chronic suppurative otitis media. ( 29151379 )
2018
3
Risk factors of sensorineural hearing loss in patients with unilateral safe chronic suppurative otitis media. ( 29331307 )
2018
4
Efficacy of Empirical Therapy With Combined Ciprofloxacin Versus Topical Drops Alone in Patients With Tubotympanic Chronic Suppurative Otitis Media: A Randomized Double-Blind Controlled Trial. ( 29348711 )
2018
5
Sensorineural hearing loss in patients with chronic suppurative otitis media: Is there a significant correlation? ( 28465813 )
2017
6
Facial Nerve Paralysis in Acute Suppurative Otitis Media-Management. ( 28239580 )
2017
7
Quality of life measurements for patients with chronic suppurative otitis media: Italian adaptation of "Chronic Ear Survey". ( 28374871 )
2017
8
Day-case management of chronic suppurative otitis media with cholesteatoma with canal wall down technique surgery: long-term follow-up. ( 29071059 )
2017
9
Microbiology of Chronic Suppurative Otitis Media in a Tertiary Care Hospital in Bangladesh. ( 28919615 )
2017
10
High-frequency conductive hearing loss as a diagnostic test for incomplete ossicular discontinuity in non-cholesteatomatous chronic suppurative otitis media. ( 29267386 )
2017
11
[The influence of interleukin gene polymorphism on the serum cytokine level in the patients presenting with chonic suppurative otitis media]. ( 28631672 )
2017
12
Gradenigo's Syndrome in a Patient with Chronic Suppurative Otitis Media, Petrous Apicitis, and Meningitis. ( 28955030 )
2017
13
Impact of Chronic Suppurative Otitis Media in Pediatric Cochlear Implant Recipients-Insight into the Challenges from a Tertiary Referral Center in UK. ( 28333779 )
2017
14
Comparative Evaluation of Tympanoplasty with or Without Mastoidectomy in Treatment of Chronic Suppurative Otitis Media Tubotympanic Type. ( 28607885 )
2017
15
Prevalence of paediatric chronic suppurative otitis media and hearing impairment in rural Malawi: A cross-sectional survey. ( 29267304 )
2017
16
Central Nervous System Inflammatory Myofibroblastic Tumor Masquerading as Chronic Suppurative Otitis Media. ( 28904584 )
2017
17
Mycology of chronic suppurative otitis media-cholesteatoma disease: An evaluative study. ( 29306568 )
2017
18
Recurrent otorrhea in chronic suppurative otitis media: is biofilm the missing link? ( 28466356 )
2017
19
Fluoroquinolone-Resistant Alcaligenes faecalis Related to Chronic Suppurative Otitis Media, Angola. ( 28930018 )
2017
20
Changes in antibiotic resistance in recurrent Pseudomonas aeruginosa infections of chronic suppurative otitis media. ( 27792822 )
2016
21
Preoperative Predictors in Chronic Suppurative Otitis Media for Ossicular Chain Discontinuity: A Cross-Sectional Study. ( 27490829 )
2016
22
Aspergillus fumigatus carrying TR34/L98H resistance allele causing complicated suppurative otitis media in Tanzania: Call for improved diagnosis of fungi in sub-Saharan Africa. ( 27589956 )
2016
23
Surveillance of bacteria Pseudomonas aeruginosa and MRSA associated with chronic suppurative otitis media. ( 27177975 )
2016
24
Predictors of disease complications and treatment outcome among patients with chronic suppurative otitis media attending a tertiary hospital, Mwanza Tanzania. ( 26766925 )
2016
25
Chronic Suppurative Otitis Media Complicated With Mastoiditis: An Unusual Presentation of Tuberculosis. ( 27865308 )
2016
26
Evaluation of Role of Mastoid Surgery in the Management of Safe Chronic Suppurative Otitis Media. ( 27833868 )
2016
27
The evaluation of eustachian tube paratubal structures using magnetic resonance imaging in patients with chronic suppurative otitis media. ( 27008280 )
2016
28
Etiological factors associated with chronic suppurative otitis media in a population of Han adults in China. ( 27206699 )
2016
29
Frequency of Sensorineural hearing loss in chronic suppurative otitis media. ( 27895351 )
2016
30
Molecular Microbiological Profile of Chronic Suppurative Otitis Media. ( 27487953 )
2016
31
Chronic suppurative otitis media, middle ear pathology and corresponding hearing loss in a cohort of Greenlandic children. ( 26968069 )
2016
32
Characterization of the T-cell subpopulations in the granulation tissues of chronic suppurative otitis media. ( 27313854 )
2016
33
Why are ototopical aminoglycosides still first-line therapy for chronic suppurative otitis media? A systematic review and discussion of aminoglycosides versus quinolones. ( 26584651 )
2016
34
Prevalence and associated factors of chronic suppurative otitis media: Data from the Korea National Health and Nutrition Examination Survey, 2009-2012. ( 27076099 )
2016
35
Do tissue spears used to clear ear canal pus improve hearing? A case series study of hearing in remote Australian Aboriginal children with chronic suppurative otitis media before and after dry mopping with tissue spears. ( 26685792 )
2016
36
A case of chronic suppurative otitis media caused by KerstersiaA gyiorum. ( 26303793 )
2015
37
Polymorphisms in Toll-like receptors 2 and 4 genes and their expression in chronic suppurative otitis media. ( 26055429 )
2015
38
Impact of Educational Program on the Management of Chronic Suppurative Otitis Media among Children. ( 25792984 )
2015
39
Comparative bactericidal activity of four fluoroquinolones against Pseudomonas aeruginosa isolated from chronic suppurative otitis media. ( 26472937 )
2015
40
Varicella vasculopathy and chronic suppurative otitis media: Differential diagnosis for isolated sixth nerve palsy. ( 26655013 )
2015
41
Chronic suppurative otitis media due to nontuberculous mycobacteria: A case of successful treatment with topical boric acid. ( 26026892 )
2015
42
Correction: Is chronic suppurative otitis media a neglected tropical disease? ( 25915036 )
2015
43
Patency of the aditus ad antrum in tubotympanic chronic suppurative otitis media. ( 25422281 )
2015
44
Observations on the current bacteriological profile of chronic suppurative otitis media in South eastern Nigeria. ( 25861532 )
2015
45
Is chronic suppurative otitis media a neglected tropical disease? ( 25811602 )
2015
46
Efficacy and safety of ofloxacin and its combination with dexamethasone in chronic suppurative otitis media. A randomised, double blind, parallel group, comparative study. ( 26015650 )
2015
47
Current concepts in the pathogenesis and treatment of chronic suppurative otitis media. ( 26248613 )
2015
48
Prevalence of Chronic Suppurative Otitis Media (CSOM) and Associated Hearing Impairment Among School-aged Children in Yemen. ( 26421117 )
2015
49
Role of Acetic Acid Irrigation in Medical Management of Chronic Suppurative Otitis Media: A Comparative Study. ( 26405670 )
2015
50
Microbiology of chronic suppurative otitis media at Queen Elizabeth Central Hospital, Blantyre, Malawi: A cross-sectional descriptive study. ( 26955432 )
2015

Variations for Suppurative Otitis Media

Expression for Suppurative Otitis Media

Search GEO for disease gene expression data for Suppurative Otitis Media.

Pathways for Suppurative Otitis Media

Pathways related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 IL1B TLR2 TLR4 TLR5
2
Show member pathways
12.47 IL1B TLR2 TLR4 TLR5
3
Show member pathways
12.39 IL1B TLR2 TLR4 TLR5
4
Show member pathways
12.35 IL1B TLR2 TLR4 TLR5
5
Show member pathways
12.25 IL1B TLR2 TLR4 TLR5
6
Show member pathways
12.13 IL1B TLR2 TLR5
7
Show member pathways
12.05 TLR2 TLR4 TLR5
8
Show member pathways
12.04 IL1B TLR2 TLR4
9 12.01 IL1B TLR2 TLR4
10 11.97 TLR2 TLR4 TLR5
11 11.86 TLR2 TLR4 TLR5
12
Show member pathways
11.84 IL1B TLR2 TLR4 TLR5
13 11.69 IL1B TLR2 TLR4
14 11.65 IL1B TLR2 TLR4
15
Show member pathways
11.65 IL1B TLR2 TLR4 TLR5
16 11.61 IL1B TLR4 TLR5
17 11.58 TLR2 TLR4 TLR5
18
Show member pathways
11.47 IL1B TLR2 TLR4 TLR5
19 11.43 TLR2 TLR4 TLR5
20 11.27 IL1B TLR2 TLR4
21 11.23 IL1B TLR2 TLR4
22
Show member pathways
11.22 IL1B TLR2 TLR4 TLR5
23 11.17 IL1B TLR4
24 11 IL1B TLR2
25 10.66 IL1B TLR2 TLR4 TLR5

GO Terms for Suppurative Otitis Media

Cellular components related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intrinsic component of plasma membrane GO:0031226 8.62 TLR2 TLR4

Biological processes related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.8 CRP IL1B TLR2 TLR4
2 response to lipopolysaccharide GO:0032496 9.75 IL1B TLR2 TLR4
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.72 IL1B TLR2 TLR4
4 cellular response to mechanical stimulus GO:0071260 9.65 IL1B TLR4 TLR5
5 inflammatory response GO:0006954 9.65 CRP IL1B TLR2 TLR4 TLR5
6 positive regulation of tumor necrosis factor production GO:0032760 9.61 TLR2 TLR4
7 toll-like receptor signaling pathway GO:0002224 9.61 TLR2 TLR4
8 positive regulation of interleukin-6 production GO:0032755 9.61 IL1B TLR2 TLR4
9 positive regulation of interferon-gamma production GO:0032729 9.6 IL1B TLR4
10 positive regulation of interferon-beta production GO:0032728 9.59 TLR2 TLR4
11 positive regulation of interleukin-12 production GO:0032735 9.58 TLR2 TLR4
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 IL1B TLR4 TLR5
13 positive regulation of interleukin-10 production GO:0032733 9.57 TLR2 TLR4
14 positive regulation of chemokine production GO:0032722 9.56 TLR2 TLR4
15 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.54 TLR2 TLR4
16 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.54 TLR2 TLR4 TLR5
17 I-kappaB phosphorylation GO:0007252 9.52 TLR2 TLR4
18 cellular response to lipoteichoic acid GO:0071223 9.51 TLR2 TLR4
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.5 IL1B TLR2 TLR4
20 positive regulation of toll-like receptor signaling pathway GO:0034123 9.46 TLR2 TLR5
21 positive regulation of NF-kappaB import into nucleus GO:0042346 9.33 IL1B TLR2 TLR4
22 regulation of cytokine secretion GO:0050707 9.13 TLR2 TLR4 TLR5
23 positive regulation of interleukin-8 production GO:0032757 8.92 IL1B TLR2 TLR4 TLR5

Molecular functions related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 9.16 TLR2 TLR4
2 interleukin-1 receptor binding GO:0005149 8.96 IL1B TLR5
3 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Suppurative Otitis Media

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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