MCID: SPP008
MIFTS: 45

Suppurative Otitis Media malady

Categories: Ear diseases

Aliases & Classifications for Suppurative Otitis Media

Aliases & Descriptions for Suppurative Otitis Media:

Name: Suppurative Otitis Media 12 14 69
Otitis Media with Effusion - Purulent 12
Otitis Media, Suppurative 42
Purulent Otitis Media 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11506
ICD10 33 H66 H66.4 H66.40
ICD9CM 35 382 382.4
MeSH 42 D010035
UMLS 69 C0029888

Summaries for Suppurative Otitis Media

Disease Ontology : 12 A otitis media which involves inflammation of the middle ear with infected effusion containing pus.

MalaCards based summary : Suppurative Otitis Media, also known as otitis media with effusion - purulent, is related to myiasis and chronic tubotympanic suppurative otitis media. An important gene associated with Suppurative Otitis Media is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and NF-KappaB Family Pathway. The drugs Dexamethasone and Ciprofloxacin have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and testes, and related phenotype is immune system.

Related Diseases for Suppurative Otitis Media

Diseases related to Suppurative Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
id Related Disease Score Top Affiliating Genes
1 myiasis 29.7 CD40LG CRP TLR4
2 chronic tubotympanic suppurative otitis media 12.6
3 non-suppurative otitis media 12.4
4 chronic purulent otitis media 12.0
5 purulent acute otitis media 12.0
6 otitis media 11.8
7 chronic atticoantral disease 11.7
8 acute serous otitis media 11.2
9 serous glue ear 11.2
10 focal labyrinthitis 11.2
11 eustachian tube disease 11.2
12 cholesteatoma 10.5
13 mastoiditis 10.5
14 pseudoainhum 10.3 TLR2 TLR4
15 primary optic atrophy 10.3 TLR2 TLR4
16 aortic coarctation 10.3 TLR2 TLR4
17 aseptic meningitis 10.3 TLR2 TLR4
18 polyarteritis nodosa 10.2 TLR2 TLR4
19 omphalocele 10.2 CRP TLR4
20 parasitic ichthyosporea infectious disease 10.2 TLR2 TLR4
21 thrombosis 10.2
22 meningitis 10.2
23 nephropathy familial with hyperuricemia 10.2 TLR2 TLR4
24 umbilical hernia 10.2 CRP HSF4
25 retinal cancer 10.2 CRP HSF4
26 epidermolysis bullosa dystrophica, ad 10.2 CRP TLR2
27 sensorineural hearing loss 10.2
28 labyrinthitis 10.2
29 central nervous system chondroma 10.2 CRP HSF4
30 arcus senilis 10.2 CRP TLR5
31 brain ischemia 10.2 CRP TLR4
32 cervical polyp 10.2 CRP SLC29A3
33 premature menopause 10.2 CRP TLR2
34 sabinas brittle hair syndrome 10.2 CRP SLC29A3
35 cardioskeletal syndrome, kuwaiti type 10.1 TLR2 TLR4 TLR5
36 fibrosis of extraocular muscles, congenital, 1 10.1 TLR2 TLR4 TLR5
37 crohn's colitis 10.1 TLR2 TLR4 TLR5
38 usher syndrome, type 2a 10.1 TLR2 TLR4 TLR5
39 neuropathy 10.1 CRP TLR4
40 abnormal retinal correspondence 10.1 TLR2 TLR4
41 tuberculosis 10.1
42 mucositis 10.1
43 nodular nonsuppurative panniculitis 10.1 CRP PGRMC1
44 appendiceal l-cell glucagon-like peptide producing tumor 10.1 CRP TLR2 TLR4
45 pericholangitis 10.1 CRP TLR2 TLR4
46 unilateral hypoactive labyrinth 10.1 CRP TLR2 TLR4
47 glycogen storage disease ix 10.1 TLR2 TLR4 TLR5
48 autoimmune disease of central nervous system 10.1 CRP TLR2
49 histiocytosis 10.1 CRP TLR2 TLR4
50 rift valley fever 10.1 CRP TLR4 TLR5

Graphical network of the top 20 diseases related to Suppurative Otitis Media:



Diseases related to Suppurative Otitis Media

Symptoms & Phenotypes for Suppurative Otitis Media

MGI Mouse Phenotypes related to Suppurative Otitis Media:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.17 CD40LG CRP SLC29A3 TLR2 TLR4 TLR5

Drugs & Therapeutics for Suppurative Otitis Media

Drugs for Suppurative Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
2
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
3
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
4 Cytochrome P-450 Enzyme Inhibitors Phase 4
5 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1
6 Anti-Infective Agents Phase 4,Phase 3,Phase 1
7 Topoisomerase Inhibitors Phase 4,Phase 1
8 Dexamethasone acetate Phase 4 1177-87-3
9 glucocorticoids Phase 4
10
protease inhibitors Phase 4
11 N-monoacetylcystine Phase 4
12 Gastrointestinal Agents Phase 4
13 HIV Protease Inhibitors Phase 4
14 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
15 Hormone Antagonists Phase 4
16 Dexamethasone 21-phosphate Phase 4
17 Hormones Phase 4
18 Peripheral Nervous System Agents Phase 4
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
20 Pharmaceutical Solutions Phase 4
21 Expectorants Phase 4
22 Protective Agents Phase 4
23 Antidotes Phase 4
24 Antiemetics Phase 4
25 Anti-Inflammatory Agents Phase 4
26 Respiratory System Agents Phase 4
27 BB 1101 Phase 4
28 Autonomic Agents Phase 4
29 Antineoplastic Agents, Hormonal Phase 4
30 Antiviral Agents Phase 4
31 Antioxidants Phase 4
32
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613 2171
33
Azithromycin Approved Phase 3 83905-01-5 55185 53477736 447043
34
Telithromycin Approved Phase 3 191114-48-4 5462516
35 Clavulanic Acid Phase 3
36 Amoxicillin-Potassium Clavulanate Combination Phase 3
37 beta-Lactamase Inhibitors Phase 3
38 Nucleic Acid Synthesis Inhibitors Phase 1
39 Pazufloxacin Phase 1
40 Fluoroquinolones Phase 1
41 Antitubercular Agents Phase 1
42
Sulfamethoxazole Approved 723-46-6 5329
43
Trimethoprim Approved, Vet_approved 738-70-5 5578
44
leucovorin Approved, Nutraceutical 58-05-9 54575, 6560146 143
45
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
46 Folic Acid Antagonists
47 Trimethoprim, Sulfamethoxazole Drug Combination
48 Vitamin B Complex
49 Antimalarials
50 Renal Agents

Interventional clinical trials:


id Name Status NCT ID Phase
1 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Not yet recruiting NCT00956748 Phase 4
2 A Comparative Study of the Outcomes of 2 Surgical Procedures for Safe Type of Chronic Otitis Media Unknown status NCT00271778 Phase 3
3 Amoxicillin-clavulanate in Treating Acute Otitis Media Evaluated by Daily Tympanometry Completed NCT01244581 Phase 3
4 TELI COM - Telithromycin in Children With Otitis Media Terminated NCT00315003 Phase 3
5 Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol Recruiting NCT02592096 Phase 1
6 Host-pathogen Interaction in Otitis Media Unknown status NCT00847756
7 Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media Completed NCT00189098
8 Procalcitonin Level and Kinetics in Children With Bacterial Infections Completed NCT00714402
9 Prevalence and Associations of Paediatric Chronic Suppurative Otitis Media and Hearing Impairment in Rural Malawi Recruiting NCT02779907
10 Treatment and Prevention of Middle Ear Morbidity in Head and Neck Cancer Patients Following Radiotherapy Not yet recruiting NCT02716376

Search NIH Clinical Center for Suppurative Otitis Media

Cochrane evidence based reviews: otitis media, suppurative

Genetic Tests for Suppurative Otitis Media

Anatomical Context for Suppurative Otitis Media

MalaCards organs/tissues related to Suppurative Otitis Media:

39
Bone, Brain, Testes, Neutrophil, Temporal Lobe, T Cells

Publications for Suppurative Otitis Media

Articles related to Suppurative Otitis Media:

(show top 50) (show all 550)
id Title Authors Year
1
Recurrent otorrhea in chronic suppurative otitis media: is biofilm the missing link? ( 28466356 )
2017
2
Sensorineural hearing loss in patients with chronic suppurative otitis media: Is there a significant correlation? ( 28465813 )
2017
3
Chronic Suppurative Otitis Media Complicated With Mastoiditis: An Unusual Presentation of Tuberculosis. ( 27865308 )
2016
4
Evaluation of Role of Mastoid Surgery in the Management of Safe Chronic Suppurative Otitis Media. ( 27833868 )
2016
5
Surveillance of bacteria Pseudomonas aeruginosa and MRSA associated with chronic suppurative otitis media. ( 27177975 )
2016
6
Molecular Microbiological Profile of Chronic Suppurative Otitis Media. ( 27487953 )
2016
7
Characterization of the T-cell subpopulations in the granulation tissues of chronic suppurative otitis media. ( 27313854 )
2016
8
Why are ototopical aminoglycosides still first-line therapy for chronic suppurative otitis media? A systematic review and discussion of aminoglycosides versus quinolones. ( 26584651 )
2016
9
Predictors of disease complications and treatment outcome among patients with chronic suppurative otitis media attending a tertiary hospital, Mwanza Tanzania. ( 26766925 )
2016
10
Frequency of Sensorineural hearing loss in chronic suppurative otitis media. ( 27895351 )
2016
11
Prevalence and associated factors of chronic suppurative otitis media: Data from the Korea National Health and Nutrition Examination Survey, 2009-2012. ( 27076099 )
2016
12
Aspergillus fumigatus carrying TR34/L98H resistance allele causing complicated suppurative otitis media in Tanzania: Call for improved diagnosis of fungi in sub-Saharan Africa. ( 27589956 )
2016
13
Etiological factors associated with chronic suppurative otitis media in a population of Han adults in China. ( 27206699 )
2016
14
Do tissue spears used to clear ear canal pus improve hearing? A case series study of hearing in remote Australian Aboriginal children with chronic suppurative otitis media before and after dry mopping with tissue spears. ( 26685792 )
2016
15
Changes in antibiotic resistance in recurrent Pseudomonas aeruginosa infections of chronic suppurative otitis media. ( 27792822 )
2016
16
The evaluation of eustachian tube paratubal structures using magnetic resonance imaging in patients with chronic suppurative otitis media. ( 27008280 )
2016
17
Chronic suppurative otitis media, middle ear pathology and corresponding hearing loss in a cohort of Greenlandic children. ( 26968069 )
2016
18
Preoperative Predictors in Chronic Suppurative Otitis Media for Ossicular Chain Discontinuity: A Cross-Sectional Study. ( 27490829 )
2016
19
Chronic suppurative otitis media due to nontuberculous mycobacteria: A case of successful treatment with topical boric acid. ( 26026892 )
2015
20
Efficacy and safety of ofloxacin and its combination with dexamethasone in chronic suppurative otitis media. A randomised, double blind, parallel group, comparative study. ( 26015650 )
2015
21
Change in Detection Rate of Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa and Their Antibiotic Sensitivities in Patients with Chronic Suppurative Otitis Media. ( 26381007 )
2015
22
Role of Acetic Acid Irrigation in Medical Management of Chronic Suppurative Otitis Media: A Comparative Study. ( 26405670 )
2015
23
Comparison of Arbekacin and Vancomycin in Treatment of Chronic Suppurative Otitis Media by Methicillin Resistant Staphylococcus aureus. ( 26028918 )
2015
24
Current concepts in the pathogenesis and treatment of chronic suppurative otitis media. ( 26248613 )
2015
25
Comparative bactericidal activity of four fluoroquinolones against Pseudomonas aeruginosa isolated from chronic suppurative otitis media. ( 26472937 )
2015
26
A case of chronic suppurative otitis media caused by KerstersiaA gyiorum. ( 26303793 )
2015
27
Varicella vasculopathy and chronic suppurative otitis media: Differential diagnosis for isolated sixth nerve palsy. ( 26655013 )
2015
28
Microbiology of chronic suppurative otitis media at Queen Elizabeth Central Hospital, Blantyre, Malawi: A cross-sectional descriptive study. ( 26955432 )
2015
29
Prevalence of Chronic Suppurative Otitis Media (CSOM) and Associated Hearing Impairment Among School-aged Children in Yemen. ( 26421117 )
2015
30
Patency of the aditus ad antrum in tubotympanic chronic suppurative otitis media. ( 25422281 )
2015
31
Mitochondrial DNA deletions in patients with chronic suppurative otitis media. ( 26620342 )
2015
32
Observations on the current bacteriological profile of chronic suppurative otitis media in South eastern Nigeria. ( 25861532 )
2015
33
Polymorphisms in Toll-like receptors 2 and 4 genes and their expression in chronic suppurative otitis media. ( 26055429 )
2015
34
Impact of Educational Program on the Management of Chronic Suppurative Otitis Media among Children. ( 25792984 )
2015
35
A systematic review of patient-reported outcome measures for chronic suppurative otitis media. ( 26371616 )
2015
36
Allergic Rhinitis in Adults with Chronic Suppurative Otitis Media. ( 26788473 )
2015
37
A study protocol for a cluster randomised trial for the prevention of chronic suppurative otitis media in children in Jumla, Nepal. ( 26425113 )
2015
38
Knowledge, attitudes, beliefs and practices related to chronic suppurative otitis media and hearing impairment in Pokhara, Nepal. ( 26567594 )
2015
39
Is chronic suppurative otitis media a neglected tropical disease? ( 25811602 )
2015
40
Complications of Chronic Suppurative Otitis Media and Their Management: A Single Institution 12 Years Experience. ( 26693451 )
2015
41
The changing epidemiological and complications profile of chronic suppurative otitis media in a developing country after two decades. ( 26611685 )
2015
42
Correction: Is chronic suppurative otitis media a neglected tropical disease? ( 25915036 )
2015
43
Role of High Resolution Computed Tomography of Mastoids in Planning Surgery for Chronic Suppurative Otitis Media. ( 26405664 )
2015
44
In vitro efficacy of N-acetylcysteine on bacteria associated with chronic suppurative otitis media. ( 25001062 )
2014
45
Preparation of levofloxacin thermo-sensitive gel and clinical application in the treatment of suppurative otitis media. ( 24597493 )
2014
46
An unusual complication of chronic suppurative otitis media: bezold abscess progressing to scapular abscess. ( 25992134 )
2014
47
A mistaken identity: rhabdomyosarcoma of the middle ear cleft misdiagnosed as chronic suppurative otitis media with temporal lobe abscess. ( 25240007 )
2014
48
Cochlear implantation in patients with chronic suppurative otitis media. ( 24569796 )
2014
49
Optimising the pre-treatment process before mobile ear surgery for chronic suppurative otitis media in Wolisso and Attat, Ethiopia. ( 24834464 )
2014
50
Comparison of chronic suppurative otitis media in rural and urban primary school children in Bangladesh. ( 24895917 )
2014

Variations for Suppurative Otitis Media

Expression for Suppurative Otitis Media

Search GEO for disease gene expression data for Suppurative Otitis Media.

Pathways for Suppurative Otitis Media

Pathways related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

(show all 17)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 CD40LG CRP PGRMC1 TLR2 TLR4 TLR5
2
Show member pathways
12.32 CD40LG TLR2 TLR4 TLR5
3
Show member pathways
12.31 CD40LG TLR2 TLR4 TLR5
4
Show member pathways
11.99 TLR2 TLR4 TLR5
5
Show member pathways
11.97 CD40LG TLR2 TLR4
6
Show member pathways
11.9 TLR2 TLR4 TLR5
7 11.89 TLR2 TLR4 TLR5
8 11.76 TLR2 TLR4 TLR5
9
Show member pathways
11.7 TLR2 TLR4 TLR5
10
Show member pathways
11.57 TLR2 TLR4 TLR5
11
Show member pathways
11.51 TLR2 TLR4 TLR5
12 11.36 TLR2 TLR4 TLR5
13 11.25 TLR2 TLR4
14 11.09 CD40LG TLR4
15 11.07 TLR2 TLR4 TLR5
16 10.82 CD40LG TLR2 TLR4
17 10.77 CD40LG TLR2 TLR4 TLR5

GO Terms for Suppurative Otitis Media

Cellular components related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intrinsic component of plasma membrane GO:0031226 8.62 TLR2 TLR4

Biological processes related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.72 CD40LG CRP TLR2 TLR4 TLR5
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.67 CD40LG TLR2 TLR4
3 positive regulation of tumor necrosis factor production GO:0032760 9.58 TLR2 TLR4
4 toll-like receptor signaling pathway GO:0002224 9.58 TLR2 TLR4
5 positive regulation of interleukin-6 production GO:0032755 9.57 TLR2 TLR4
6 positive regulation of nitric oxide biosynthetic process GO:0045429 9.56 TLR4 TLR5
7 lipopolysaccharide-mediated signaling pathway GO:0031663 9.55 TLR2 TLR4
8 positive regulation of interferon-beta production GO:0032728 9.54 TLR2 TLR4
9 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.54 TLR2 TLR4 TLR5
10 positive regulation of NF-kappaB import into nucleus GO:0042346 9.52 TLR2 TLR4
11 positive regulation of chemokine production GO:0032722 9.51 TLR2 TLR4
12 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.48 TLR2 TLR4
13 I-kappaB phosphorylation GO:0007252 9.46 TLR2 TLR4
14 cellular response to lipoteichoic acid GO:0071223 9.43 TLR2 TLR4
15 positive regulation of interleukin-8 production GO:0032757 9.43 TLR2 TLR4 TLR5
16 positive regulation of toll-like receptor signaling pathway GO:0034123 9.4 TLR2 TLR5
17 positive regulation of interleukin-12 production GO:0032735 9.33 CD40LG TLR2 TLR4
18 positive regulation of interleukin-10 production GO:0032733 9.13 CD40LG TLR2 TLR4
19 regulation of cytokine secretion GO:0050707 8.8 TLR2 TLR4 TLR5

Molecular functions related to Suppurative Otitis Media according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.33 TLR2 TLR4 TLR5
2 lipopolysaccharide binding GO:0001530 8.96 TLR2 TLR4
3 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Suppurative Otitis Media

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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