MCID: SPP003
MIFTS: 29

Suppurative Periapical Periodontitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Suppurative Periapical Periodontitis

MalaCards integrated aliases for Suppurative Periapical Periodontitis:

Name: Suppurative Periapical Periodontitis 12 14 69
Periapical Abscess 12 51 41
Suppurative Apical Periodontitis 12
Dentoalveolar Abscess 12
Apical Abscess 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2562
MeSH 41 D010482
NCIt 46 C34913
ICD10 32 K04.6 K04.7
UMLS 69 C0031024

Summaries for Suppurative Periapical Periodontitis

MalaCards based summary : Suppurative Periapical Periodontitis, also known as periapical abscess, is related to dental abscess and hypochondroplasia. An important gene associated with Suppurative Periapical Periodontitis is PIMREG (PICALM Interacting Mitotic Regulator), and among its related pathways/superpathways are Defensins and Matrix Metalloproteinases. The drugs Amoxicillin and Clindamycin have been mentioned in the context of this disorder. Related phenotype is neoplasm.

Related Diseases for Suppurative Periapical Periodontitis

Diseases related to Suppurative Periapical Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 dental abscess 11.2
2 hypochondroplasia 9.9
3 hypophosphatemic rickets, x-linked recessive 9.9
4 rickets 9.9
5 acute apical periodontitis 9.7
6 periodontitis 9.7
7 gingivitis 9.7 CTSG LTF
8 cholangitis, primary sclerosing 9.5 CTSG LTF

Graphical network of the top 20 diseases related to Suppurative Periapical Periodontitis:



Diseases related to Suppurative Periapical Periodontitis

Symptoms & Phenotypes for Suppurative Periapical Periodontitis

MGI Mouse Phenotypes related to Suppurative Periapical Periodontitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.8 CTSG LTF MMP19

Drugs & Therapeutics for Suppurative Periapical Periodontitis

Drugs for Suppurative Periapical Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
2
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
3 Amoxicillin-Potassium Clavulanate Combination Phase 4
4 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
5 Anti-Infective Agents Phase 4,Phase 2,Phase 3
6 beta-Lactamase Inhibitors Phase 4
7 Clavulanic Acid Phase 4
8 Clindamycin palmitate Phase 4
9 Clindamycin phosphate Phase 4
10
Chlorhexidine Approved, Vet_approved Phase 2, Phase 3 55-56-1 2713 9552079
11 Anti-Infective Agents, Local Phase 2, Phase 3
12 Anti-Inflammatory Agents Phase 2, Phase 3
13 Chlorhexidine gluconate Phase 2, Phase 3
14 Dermatologic Agents Phase 2, Phase 3
15 Disinfectants Phase 2, Phase 3
16 Pharmaceutical Solutions Phase 2, Phase 3
17 Root Canal Irrigants Phase 2, Phase 3
18 Neem Nutraceutical Phase 2, Phase 3
19
Acetaminophen Approved 103-90-2 1983
20
Codeine Approved, Illicit 76-57-3 5284371
21
Guaifenesin Approved, Investigational, Vet_approved 93-14-1 3516
22
Tramadol Approved, Investigational 27203-92-5 33741
23
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
24 Analgesics
25 Analgesics, Non-Narcotic
26 Analgesics, Opioid
27 Antipyretics
28 Antitussive Agents
29 Central Nervous System Depressants
30 Chlorpheniramine, phenylpropanolamine drug combination
31 Narcotics
32 Peripheral Nervous System Agents
33 Respiratory System Agents
34 Antiemetics
35 Antineoplastic Agents, Hormonal
36 Autonomic Agents
37 BB 1101
38 Dexamethasone acetate 1177-87-3
39 Gastrointestinal Agents
40 glucocorticoids
41 HIV Protease Inhibitors
42 Hormone Antagonists
43 Hormones
44 Hormones, Hormone Substitutes, and Hormone Antagonists
45
protease inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 AUGMENTIN™ in Dental Infections Completed NCT02141217 Phase 4 Amoxicillin/clavulanate;Clindamycin
2 Resolution of Pain and Swelling After the Use of Neem Leaf Extract Compared to Chlorhexidine Gluconate as an Intracanal Irrigant During Pulpectomy Not yet recruiting NCT02943759 Phase 2, Phase 3 Neem leaf extract;Chlorhexidine gluconate
3 Comparison of Two Combinations of Opioid and Non-opioid Analgesics for Acute Periradicular Abscess Completed NCT02750696 Fixed-dose oral tablet of codeine/ acetaminophen every 4 hours for 3 days;Fixed-dose oral tablet of tramadol/ acetaminophen every 4 hours for 3 days
4 Periodontal and Periapical Inflammation and Pregnancy Completed NCT00490165
5 The Effects of Dexamethasone on the Time to Pain Resolution in Dental Apical Abscess Not yet recruiting NCT03005522 oral dexamethasone;Placebo Oral Capsule

Search NIH Clinical Center for Suppurative Periapical Periodontitis

Cochrane evidence based reviews: periapical abscess

Genetic Tests for Suppurative Periapical Periodontitis

Anatomical Context for Suppurative Periapical Periodontitis

Publications for Suppurative Periapical Periodontitis

Articles related to Suppurative Periapical Periodontitis:

# Title Authors Year
1
Chondroblastic osteosarcoma mimicking periapical abscess. ( 28877285 )
2017
2
A retrospective cohort study on the association between periapical abscess, advanced periodontal disease, and the national oral health screening program among Korean adults. ( 22186394 )
2013
3
Dentin malformation with alveolar bone loss and periapical abscess formation. ( 10197342 )
1999

Variations for Suppurative Periapical Periodontitis

Expression for Suppurative Periapical Periodontitis

Search GEO for disease gene expression data for Suppurative Periapical Periodontitis.

Pathways for Suppurative Periapical Periodontitis

Pathways related to Suppurative Periapical Periodontitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.32 CTSG LTF
2
Show member pathways
10.62 CTSG MMP19

GO Terms for Suppurative Periapical Periodontitis

Cellular components related to Suppurative Periapical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 8.62 CTSG LTF

Biological processes related to Suppurative Periapical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.5 CTSG LTF MMP19
2 cellular protein metabolic process GO:0044267 9.4 CTSG LTF
3 defense response to bacterium GO:0042742 9.37 CTSG LTF
4 defense response to Gram-negative bacterium GO:0050829 9.26 CTSG LTF
5 extracellular matrix disassembly GO:0022617 9.16 CTSG MMP19
6 antimicrobial humoral response GO:0019730 8.96 CTSG LTF
7 antibacterial humoral response GO:0019731 8.62 CTSG LTF

Molecular functions related to Suppurative Periapical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.26 CTSG LTF
2 serine-type peptidase activity GO:0008236 9.16 CTSG LTF
3 peptidase activity GO:0008233 9.13 CTSG LTF MMP19
4 serine-type endopeptidase activity GO:0004252 8.8 CTSG LTF MMP19

Sources for Suppurative Periapical Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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