PNET
MCID: SPR008
MIFTS: 40

Supratentorial Primitive Neuroectodermal Tumor (PNET) malady

Rare diseases, Cancer diseases, Neuronal diseases categories

Summaries for Supratentorial Primitive Neuroectodermal Tumor

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MalaCards based summary: Supratentorial Primitive Neuroectodermal Tumor, also known as neuroectodermal tumor, peripheral, is related to medulloblastoma and merkel cell carcinoma. An important gene associated with Supratentorial Primitive Neuroectodermal Tumor is SLITRK6 (SLIT and NTRK-like family, member 6), and among its related pathways are SIDS Susceptibility Pathways and Neuroscience. The compounds 111in-pentetreotide and amine have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotypes are nervous system and behavior/neurological.

Aliases & Classifications for Supratentorial Primitive Neuroectodermal Tumor

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Supratentorial Primitive Neuroectodermal Tumor, Aliases & Descriptions:

Name: Supratentorial Primitive Neuroectodermal Tumor 9 42 11 61
Neuroectodermal Tumor, Peripheral 61
Peripheral Neuroectodermal Tumor 42
Neuroectodermal Tumor, Primitive 61
 
Primative Neuroectodermal Tumor 42
Supratentorial Pnet 9
Pnet 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:4791
SNOMED-CT56 39781001
NCIt39 C6968

Related Diseases for Supratentorial Primitive Neuroectodermal Tumor

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Diseases related to Supratentorial Primitive Neuroectodermal Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1medulloblastoma31.1SSTR2, SYP, S100B
2merkel cell carcinoma30.9SYP
3neuroblastoma30.8SYP
4neuroendocrine tumor30.4SSTR2
5pilocytic astrocytoma30.4SYP, S100B
6olfactory neuroblastoma30.0S100B, SYP
7neuroectodermal tumor11.2
8sarcoma10.6
9supratentorial primitive neuroectodermal tumors, childhood10.6
10peripheral primitive neuroectodermal tumor10.4
11malignant peripheral neuroectodermal tumor of the cervix uteri10.4
12atypical teratoid rhabdoid tumor10.4
13epidermolysis bullosa simplex10.4
14childhood medulloblastoma10.4
15astrocytoma10.4
16epidermolysis bullosa10.4
17mediastinitis10.4
18osteosarcoma10.4
19pineoblastoma10.4
20pineoblastoma, childhood10.4
21subependymal giant cell astrocytoma10.4SYP
22dysembryoplastic neuroepithelial tumor10.4SYP
23paraganglioma10.4SYP
24malignant peripheral neuroectodermal tumor of the corpus uteri10.3
25pancreatitis10.2
26amyotrophic lateral sclerosis type 1410.2SYP
27rhabdoid tumor10.2
28soft tissue peripheral neuroepithelioma10.2
29extraosseous ewing's sarcoma10.2
30prostatitis10.2
31vaginitis10.2
32teratocarcinoma10.1SYP, ASCL1
33thyroid medullary carcinoma10.1ASCL1, SSTR2
34gastrinoma10.1SYP, SSTR2
35cerebral primitive neuroectodermal tumor10.1
36neuronitis10.1
37cerebritis10.1
38glioblastoma10.1
39teratoma10.1
40papillary ependymoma10.1S100B, SYP
41choroid plexus papilloma10.1SYP, S100B
42papillary carcinoma10.1SYP, SSTR2
43pineocytoma10.1S100B, SYP
44granular cell tumor10.0SYP, S100B
45ganglioneuroblastoma10.0SYP, S100B
46hemangioblastoma10.0SYP, S100B
47pancreatic cancer10.0SYP, SSTR2
48ganglioglioma10.0S100B, SYP
49ganglioneuroma10.0SYP, S100B
50neurofibroma10.0S100B, SYP

Graphical network of the top 20 diseases related to Supratentorial Primitive Neuroectodermal Tumor:



Diseases related to supratentorial primitive neuroectodermal tumor

Symptoms for Supratentorial Primitive Neuroectodermal Tumor

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Drugs & Therapeutics for Supratentorial Primitive Neuroectodermal Tumor

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Drug clinical trials:

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Genetic Tests for Supratentorial Primitive Neuroectodermal Tumor

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Anatomical Context for Supratentorial Primitive Neuroectodermal Tumor

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MalaCards organs/tissues related to Supratentorial Primitive Neuroectodermal Tumor:

32
T cells

Animal Models for Supratentorial Primitive Neuroectodermal Tumor or affiliated genes

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MGI Mouse Phenotypes related to Supratentorial Primitive Neuroectodermal Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.9ASCL1, SSTR2, SYP, SLITRK6, DDC
2MP:00053867.3SLITRK6, S100B, SSTR2, ASCL1, DDC

Publications for Supratentorial Primitive Neuroectodermal Tumor

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Articles related to Supratentorial Primitive Neuroectodermal Tumor:

(show all 45)
idTitleAuthorsYear
1
Supratentorial primitive neuroectodermal tumor presenting with intracranial hemorrhage in adult. (24966562)
2014
2
A patient tumor-derived orthotopic xenograft mouse model replicating the group 3 supratentorial primitive neuroectodermal tumor in children. (24470556)
2014
3
A supratentorial primitive neuroectodermal tumor presenting with intracranial hemorrhage in a 42-year-old man: a case report and review of the literature. (23537064)
2013
4
Proton radiation therapy for pediatric medulloblastoma and supratentorial primitive neuroectodermal tumors: outcomes for very young children treated with upfront chemotherapy. (23790826)
2013
5
Supratentorial primitive neuroectodermal tumor in an adult: a case report and review of the literature. (23095172)
2012
6
Severe allergic reactions to thiol-based cytoprotective agents mesna and amifostine in a child with a supratentorial primitive neuroectodermal tumor. (21646919)
2011
7
Treatment of a supratentorial primitive neuroectodermal tumor using magnetic resonance-guided laser-induced thermal therapy. (22044371)
2011
8
Late complete remission of supratentorial primitive neuroectodermal tumor (CNS-PNET) after multiple relapses. (21113945)
2011
9
Supratentorial primitive neuroectodermal tumors of the central nervous system in adults: molecular and histopathologic analysis of 12 cases. (21378543)
2011
10
Supratentorial primitive neuroectodermal tumor (PNET): an uncommon location. (22297899)
2011
11
Upregulation of SOX2, NOTCH1, and ID1 in supratentorial primitive neuroectodermal tumors: a distinct differentiation pattern from that of medulloblastomas. (20515335)
2010
12
Supratentorial primitive neuroectodermal tumor metastasis to the abdomen via a ventriculoperitoneal shunt. (20526591)
2010
13
Reduced-dose craniospinal radiotherapy followed by high-dose chemotherapy and autologous stem cell rescue for children with newly diagnosed high-risk medulloblastoma or supratentorial primitive neuroectodermal tumor. (21120191)
2010
14
Successful radiation therapy for supratentorial primitive neuroectodermal tumor and epidermolysis bullosa simplex. (19760773)
2010
15
Lipomatous supratentorial primitive neuroectodermal tumor with glioblastomatous differentiation. (19118780)
2009
16
Frequent IDH1 mutations in supratentorial primitive neuroectodermal tumors (sPNET) of adults but not children. (19411854)
2009
17
Secondary supratentorial primitive neuroectodermal tumor following treatment of childhood osteosarcoma. (19434734)
2009
18
Therapeutic Difficulty in a Case of Supratentorial Primitive Neuroectodermal Tumor Diagnosed during Pregnancy. (19242570)
2009
19
A supratentorial primitive neuroectodermal tumor in an adult: a case report and review of the literature. (17713720)
2008
20
Different hypermethylation status of RASSF1A in medulloblastoma and supratentorial primitive neuroectodermal tumor]. (17374234)
2007
21
High-dose chemotherapy and autologous stem cell rescue in children with newly diagnosed high-risk or relapsed medulloblastoma or supratentorial primitive neuroectodermal tumor. (17066462)
2007
22
Supratentorial primitive neuroectodermal tumor during pregnancy. Case report. (17505462)
2007
23
High-resolution array-based comparative genomic hybridization of medulloblastomas and supratentorial primitive neuroectodermal tumors. (16783165)
2006
24
Supratentorial primitive neuroectodermal tumor (sPNET). (16612986)
2006
25
Long-term relapse-free survival with supratentorial primitive neuroectodermal tumor in an adult: a case report. (16528456)
2006
26
Histone deacetylase inhibitors induce cell death in supratentorial primitive neuroectodermal tumor cells. (17016591)
2006
27
Molecular genetics of supratentorial primitive neuroectodermal tumors and pineoblastoma. (16398467)
2005
28
Epigenetic inactivation of DLC-1 in supratentorial primitive neuroectodermal tumor. (15712180)
2005
29
High-dose chemotherapy with autologous stem cell rescue for children with high risk and recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors. (15719272)
2005
30
Supratentorial primitive neuroectodermal tumor in an aged patient--case report--. (16247240)
2005
31
Secondary supratentorial primitive neuroectodermal tumor following irradiation in a patient with low-grade astrocytoma. (15661719)
2005
32
Somatostatin receptor subtype 2 is expressed by supratentorial primitive neuroectodermal tumors of childhood and can be targeted for somatostatin receptor imaging. (15131035)
2004
33
Results of a phase II upfront window of pharmacokinetically guided topotecan in high-risk medulloblastoma and supratentorial primitive neuroectodermal tumor. (15310781)
2004
34
Patterns of failure in relation to radiotherapy fields in supratentorial primitive neuroectodermal tumor. (15001261)
2004
35
Supratentorial primitive neuroectodermal tumor: report of a surgical case]. (15352632)
2004
36
Valproic acid induces differentiation of a supratentorial primitive neuroectodermal tumor. (15739631)
2004
37
PTEN and DMBT1 homozygous deletion and expression in medulloblastomas and supratentorial primitive neuroectodermal tumors. (15547761)
2004
38
Unusual aberration involving the short arm of chromosome 11 in an 8-month-old patient with a supratentorial primitive neuroectodermal tumor. (12606132)
2003
39
Mediastinal T-cell lymphoma in a boy 7 years after treatment of supratentorial primitive neuroectodermal tumor. (12902924)
2003
40
A novel case of a CAT to AAT transversion in codon 179 of the p53 gene in a supratentorial primitive neuroectodermal tumor harbored by a young girl. Case report and review of the literature. (12837982)
2003
41
Cytogenetic and histopathologic studies of congenital supratentorial primitive neuroectodermal tumors: a case report. (11349224)
2001
42
Feasibility of four consecutive high-dose chemotherapy cycles with stem-cell rescue for patients with newly diagnosed medulloblastoma or supratentorial primitive neuroectodermal tumor after craniospinal radiotherapy: results of a collaborative study. (11352962)
2001
43
Supratentorial primitive neuroectodermal tumor in children: clinical features, treatment outcome and prognostic factors. (10447606)
1999
44
A continuous cell line (KK-2) from a supratentorial primitive neuroectodermal tumor. (1323907)
1992
45
Immunophenotype profile of childhood medulloblastomas and supratentorial primitive neuroectodermal tumors using 16 monoclonal antibodies. (2196109)
1990

Variations for Supratentorial Primitive Neuroectodermal Tumor

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Expression for genes affiliated with Supratentorial Primitive Neuroectodermal Tumor

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Expression patterns in normal tissues for genes affiliated with Supratentorial Primitive Neuroectodermal Tumor

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Pathways for genes affiliated with Supratentorial Primitive Neuroectodermal Tumor

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Pathways related to Supratentorial Primitive Neuroectodermal Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.9SSTR2, ASCL1, DDC
28.6S100B, SYP, DDC

Compounds for genes affiliated with Supratentorial Primitive Neuroectodermal Tumor

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Compounds related to Supratentorial Primitive Neuroectodermal Tumor according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1111in-pentetreotide449.7SYP, SSTR2
2amine449.7SYP, DDC
3spec-t449.6DDC, SSTR2
45-hydroxytryptamine449.6DDC, SYP
5s 100449.5S100B, SYP
6reticulin449.5S100B, SYP
7mucicarmine449.5S100B, SYP
8b 723449.5SYP, S100B
9hematoxylin449.4S100B, SYP
10dbc-amp449.4S100B, SYP
11agarose449.2S100B, DDC
12formaldehyde44 2510.2S100B, SYP
13histamine44 29 2511.1SYP, SSTR2, DDC
14l-amino acid449.0S100B, SYP, DDC
15catecholamine449.0DDC, SYP, S100B
16choline44 25 1211.0DDC, SYP, S100B
17gaba449.0DDC, SYP, S100B
18histidine449.0S100B, SYP, DDC
19norepinephrine44 25 1210.9DDC, SYP, S100B
20gtp44 299.9DDC, SYP, S100B
21acth448.9S100B, SYP, SSTR2
22ionomycin448.8S100B, SYP
23paraffin448.8S100B, SYP, SSTR2
24forskolin44 50 1210.8S100B, SYP, SSTR2
25glutamate448.8S100B, SYP, DDC
26progesterone44 29 60 25 1212.8SSTR2, SYP, S100B
27vegf448.7SSTR2, SYP, S100B
28retinoic acid44 259.6S100B, SYP, ASCL1
29estrogen448.5SSTR2, SYP, S100B
30glucose448.5S100B, SSTR2, DDC
31dopamine44 29 25 1210.9S100B, SYP, SSTR2, ASCL1, DDC
32tyrosine447.9DDC, ASCL1, SSTR2, SYP, S100B

GO Terms for genes affiliated with Supratentorial Primitive Neuroectodermal Tumor

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Cellular components related to Supratentorial Primitive Neuroectodermal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430258.7S100B, ASCL1, DDC

Biological processes related to Supratentorial Primitive Neuroectodermal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonogenesisGO:0074099.2SLITRK6, S100B
2regulation of neuronal synaptic plasticityGO:0481688.8S100B, SYP

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