MCID: SWT002
MIFTS: 38

Sweat Gland Cancer

Categories: Skin diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Sweat Gland Cancer

MalaCards integrated aliases for Sweat Gland Cancer:

Name: Sweat Gland Cancer 12 14
Sweat Gland Neoplasms 42 69
Sweat Gland Neoplasm 12 14
Primary Malignant Neoplasm of Sweat Gland 69
Malignant Tumor of the Sweat Gland 12
Malignant Neoplasm of Sweat Gland 12
Tumor of the Sweat Gland 12
Neoplasm of Sweat Gland 12
Sweat Gland Tumor Nos 12
Sweat Gland Tumor 12

Classifications:



Summaries for Sweat Gland Cancer

MalaCards based summary : Sweat Gland Cancer, also known as sweat gland neoplasms, is related to eccrine sweat gland neoplasm and ercc2-related xeroderma pigmentosum. An important gene associated with Sweat Gland Cancer is KRT5 (Keratin 5), and among its related pathways/superpathways are Endometrial cancer and Integrated Breast Cancer Pathway. The drugs lanreotide and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include skin, salivary gland and pituitary, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Sweat Gland Cancer

Diseases related to Sweat Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 255)
id Related Disease Score Top Affiliating Genes
1 eccrine sweat gland neoplasm 11.2
2 ercc2-related xeroderma pigmentosum 10.9 KRT14 KRT5
3 pachyonychia congenita 3 10.9 KRT14 KRT5
4 dowling-degos disease 1 10.9 KRT14 KRT5
5 eccrine adenocarcinoma 10.8
6 apocrine adenocarcinoma 10.8
7 hidradenocarcinoma 10.8
8 light chain deposition disease 10.8 KRT14 KRT5
9 bladder tuberculosis 10.8 ERBB2 KRT5
10 acantholytic acanthoma 10.8 KRT14 KRT5
11 epidermolysis bullosa simplex-mp 10.8 KRT14 KRT5
12 gastritis 10.8 ERBB2 PGR
13 vipoma 10.8 KRT15 KRT20
14 skin sarcoma 10.8 ERBB2 PGR
15 her2-receptor negative breast cancer 10.8 ERBB2 PGR
16 sed, maroteaux type 10.7 KRT14 KRT5
17 bartholin's gland benign neoplasm 10.7 ESR1 PGR
18 gallbladder leiomyoma 10.7 ESR1 PGR
19 pigmented basal cell carcinoma 10.7 KRT14 KRT20
20 fallopian tube benign neoplasm 10.7 ESR1 PGR
21 paranasal sinus disease 10.7 ESR1 PGR
22 dartoic leiomyoma 10.7 ESR1 PGR
23 familial periodic paralysis 10.7 KRT5 KRT8
24 deafness, autosomal dominant 8/12 10.7 ESR1 PGR
25 vulvitis 10.7 KRT15 KRT8
26 adult spinal cord glioblastoma multiforme 10.7 ERBB2 KRT8
27 lipid-cell variant infiltrating bladder urothelial carcinoma 10.7 KRT5 TP53
28 nerve fibre bundle defect 10.7 ERBB2 ESR1
29 blastema predominant kidney wilms' tumor 10.7 PGR TP53
30 superficial basal cell carcinoma 10.6 ESR1 PGR
31 anal squamous cell carcinoma 10.6 KRT5 TP53
32 bladder colloid adenocarcinoma 10.6 ESR1 PGR
33 kallmann syndrome 10.6 ERBB2 PGR
34 endophthalmitis 10.6 ESR1 PGR
35 fallopian tube squamous cell carcinoma 10.6 KRT5 TP53
36 malignant conjunctival melanoma 10.6 KRT15 TP53
37 breast myoepithelial neoplasm 10.6 PGR TP53
38 congenital disorder of glycosylation, type if 10.6 ERBB2 TP53
39 leiomyoma cutis 10.6 PGR TP53
40 prostatic acinar adenocarcinoma 10.6 PGR TP53
41 endocervicitis 10.6 ERBB2 TP53
42 intraductal breast myoepitheliosis 10.6 PGR TP53
43 fallopian tube clear cell adenocarcinoma 10.6 ESR1 TP53
44 cutaneous mucoepidermoid carcinoma 10.5 ESR1 PGR
45 intrahepatic bile duct adenoma 10.5 KRT20 TP53
46 extrahepatic bile duct adenoma 10.5 KRT20 TP53
47 enchondromatosis, multiple, ollier type 10.5 KRT20 PIP
48 holoprosencephaly 6 10.5 ESR1 PGR
49 animal phobia 10.5 ERBB2 TP53
50 rectum adenoma 10.5 KRT20 PIP

Graphical network of the top 20 diseases related to Sweat Gland Cancer:



Diseases related to Sweat Gland Cancer

Symptoms & Phenotypes for Sweat Gland Cancer

MGI Mouse Phenotypes related to Sweat Gland Cancer:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.97 AR ERBB2 ESR1 KRT14 KRT5 KRT8
2 endocrine/exocrine gland MP:0005379 9.87 ESR1 KRT14 PGR PIP TP53 AR
3 integument MP:0010771 9.86 ESR1 KRT14 KRT5 MME PGR TP53
4 limbs/digits/tail MP:0005371 9.63 AR ERBB2 ESR1 KRT5 PGR TP53
5 neoplasm MP:0002006 9.43 AR ERBB2 ESR1 KRT14 PGR TP53
6 reproductive system MP:0005389 9.23 AR ERBB2 ESR1 KRT14 KRT8 PGR

Drugs & Therapeutics for Sweat Gland Cancer

Drugs for Sweat Gland Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 lanreotide Approved Phase 3 108736-35-2
2
Somatostatin Approved Phase 3 38916-34-6, 51110-01-1 53481605
3 Angiopeptin Phase 3
4 Hormone Antagonists Phase 3
5 Hormones Phase 3
6 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
7
Etanercept Approved, Investigational Phase 2 185243-69-0
8
nivolumab Approved Phase 2 946414-94-4
9 Analgesics Phase 2
10 Analgesics, Non-Narcotic Phase 2
11 Anti-Inflammatory Agents Phase 2
12 Anti-Inflammatory Agents, Non-Steroidal Phase 2
13 Antirheumatic Agents Phase 2
14 Gastrointestinal Agents Phase 2
15 Immunosuppressive Agents Phase 2
16 Peripheral Nervous System Agents Phase 2
17 Antioxidants Phase 1, Phase 2
18 Protective Agents Phase 1, Phase 2
19 Superoxide Dismutase Phase 1, Phase 2
20 Antibodies Phase 2
21 Antibodies, Monoclonal Phase 2
22 Immunoglobulins Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 The Use of Human Acellular Dermal Matrix to Improve Infraauricular Depressed Deformities and Frey's Syndrome Completed NCT01414790 Phase 3
2 Lanreotide as Primary Treatment for Acromegalic Patients With Pituitary Gland Macroadenoma Completed NCT00690898 Phase 3 Lanreotide autogel 120 mg
3 Etanercept for Treatment of Hidradenitis Completed NCT00107991 Phase 2 etanercept
4 Study of APN201 (Liposomal Recombinant Human Cu/Zn-Superoxide Dismutase) for the Prevention of Radiation-induced Dermatitis in Women With Breast Cancer Completed NCT01513278 Phase 1, Phase 2 APN201;Placebo
5 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2
6 Trial of Radiotherapy and Panitumumab in Salivary Gland Malignancies Withdrawn NCT00984217 Phase 2 Panitumumab
7 Assessment of the Prevalence of Small Fiber Peripheral Neuropathy Among Non-diabetic Obese Patients Recruiting NCT02767583
8 Miradry Treatment for Focal Axillary Hyperhidrosis Recruiting NCT02295891
9 Chronic Inflammatory Disease, Lifestyle and Treatment Response Not yet recruiting NCT03173144

Search NIH Clinical Center for Sweat Gland Cancer

Cochrane evidence based reviews: sweat gland neoplasms

Genetic Tests for Sweat Gland Cancer

Anatomical Context for Sweat Gland Cancer

MalaCards organs/tissues related to Sweat Gland Cancer:

39
Skin, Salivary Gland, Pituitary

Publications for Sweat Gland Cancer

Articles related to Sweat Gland Cancer:

id Title Authors Year
1
Neck sweat gland cancer hemorrhage. Case study. ( 23788972 )
2013

Variations for Sweat Gland Cancer

Expression for Sweat Gland Cancer

Search GEO for disease gene expression data for Sweat Gland Cancer.

Pathways for Sweat Gland Cancer

GO Terms for Sweat Gland Cancer

Cellular components related to Sweat Gland Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neuron projection terminus GO:0044306 9.16 MME SYP
2 keratin filament GO:0045095 9.13 KRT14 KRT5 KRT8
3 intermediate filament GO:0005882 9.02 KRT14 KRT15 KRT20 KRT5 KRT8

Biological processes related to Sweat Gland Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.78 AR ERBB2 PIP TP53
2 epidermis development GO:0008544 9.61 KRT14 KRT15 KRT5
3 mammary gland alveolus development GO:0060749 9.46 AR ESR1
4 steroid hormone mediated signaling pathway GO:0043401 9.43 AR ESR1 PGR
5 replicative senescence GO:0090399 9.4 MME TP53
6 positive regulation of transcription from RNA polymerase III promoter GO:0045945 9.37 AR ERBB2
7 keratinization GO:0031424 9.35 KRT14 KRT15 KRT20 KRT5 KRT8
8 hemidesmosome assembly GO:0031581 9.32 KRT14 KRT5
9 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 9.16 AR PGR
10 cornification GO:0070268 9.02 KRT14 KRT15 KRT20 KRT5 KRT8

Molecular functions related to Sweat Gland Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.83 AR ESR1 MME PGR TP53
2 enzyme binding GO:0019899 9.71 AR ESR1 PGR TP53
3 ATPase binding GO:0051117 9.54 AR ESR1 PGR
4 steroid hormone receptor activity GO:0003707 9.5 AR ESR1 PGR
5 scaffold protein binding GO:0097110 9.43 KRT15 KRT5 KRT8
6 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.33 AR ESR1 PGR
7 steroid binding GO:0005496 9.13 AR ESR1 PGR
8 structural constituent of cytoskeleton GO:0005200 8.92 KRT14 KRT15 KRT20 KRT5

Sources for Sweat Gland Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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