MCID: SWT002
MIFTS: 35

Sweat Gland Cancer

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Sweat Gland Cancer

MalaCards integrated aliases for Sweat Gland Cancer:

Name: Sweat Gland Cancer 12 14
Sweat Gland Neoplasms 41 69
Sweat Gland Neoplasm 12 14
Primary Malignant Neoplasm of Sweat Gland 69
Malignant Tumor of the Sweat Gland 12
Malignant Neoplasm of Sweat Gland 12
Tumor of the Sweat Gland 12
Neoplasm of Sweat Gland 12
Sweat Gland Tumor Nos 12
Sweat Gland Tumor 12

Classifications:



Summaries for Sweat Gland Cancer

MalaCards based summary : Sweat Gland Cancer, also known as sweat gland neoplasms, is related to eccrine adenocarcinoma and eccrine sweat gland neoplasm. An important gene associated with Sweat Gland Cancer is KRT7 (Keratin 7), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. The drugs nivolumab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are digestive/alimentary and embryo

Related Diseases for Sweat Gland Cancer

Diseases related to Sweat Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 289)
# Related Disease Score Top Affiliating Genes
1 eccrine adenocarcinoma 32.0 ESR1 KRT7
2 eccrine sweat gland neoplasm 31.4 DAND5 KRT15 KRT20 KRT7 TP53
3 hidradenocarcinoma 30.8 ERBB2 ESR1 KRT5 KRT7 TP53
4 eccrine papillary adenocarcinoma 30.6 KRT7 PGR
5 papillary adenocarcinoma 30.3 ERBB2 KRT7 PGR
6 apocrine adenocarcinoma 30.2 AR ERBB2 ESR1 KRT5 KRT7 PGR
7 hidradenoma 11.1
8 acrospiroma 11.1
9 inverted transitional papilloma 10.6 KRT5 KRT7
10 sensory organ benign neoplasm 10.6 KRT5 KRT7
11 middle ear adenoma 10.6 KRT5 KRT7
12 bile duct mucoepidermoid carcinoma 10.6 KRT5 KRT7
13 epidermolysis bullosa simplex, autosomal recessive 1 10.5 KRT14 KRT5
14 papillary adenoma 10.5 KRT5 KRT7
15 epidermolysis bullosa simplex, localized 10.5 KRT14 KRT5
16 lichen planopilaris 10.5 KRT14 KRT5
17 endosalpingiosis 10.5 KRT7 PGR
18 eccrine porocarcinoma 10.5 KRT15 KRT7
19 breast cystic hypersecretory carcinoma 10.5 ERBB2 KRT5
20 epidermolysis bullosa simplex, generalized 10.5 KRT14 KRT5
21 cystic basal cell carcinoma 10.5 KRT20 KRT7
22 malignant mixed mullerian tumor 10.5 KRT7 PGR
23 lung acinar adenocarcinoma 10.5 KRT20 KRT7
24 vaginal benign neoplasm 10.5 KRT20 KRT7
25 seminal vesicle adenocarcinoma 10.5 KRT20 KRT7
26 transverse colon cancer 10.5 KRT20 KRT7
27 ovarian large-cell neuroendocrine carcinoma 10.5 KRT20 KRT7
28 vaginal adenoma 10.5 KRT20 KRT7
29 vaginal tubulovillous adenoma 10.5 KRT20 KRT7
30 benign metastasizing leiomyoma 10.5 KRT7 PGR
31 eyelid neoplasm 10.5 KRT20 KRT7
32 krukenberg carcinoma 10.5 KRT20 KRT7
33 pancreatic serous cystadenoma 10.5 KRT7 PGR
34 scirrhous adenocarcinoma 10.5 ERBB2 PGR
35 breast apocrine carcinoma 10.5 ERBB2 PGR
36 large intestine adenocarcinoma 10.5 KRT20 KRT7
37 glandular cystitis 10.5 KRT20 KRT7
38 linitis plastica 10.5 KRT20 KRT7
39 small cell carcinoma of the bladder 10.5 KRT20 KRT7
40 adenoid squamous cell carcinoma 10.4 KRT20 KRT7
41 epidermolysis bullosa simplex with mottled pigmentation 10.4 KRT14 KRT5
42 mucinous adenofibroma 10.4 ESR1 KRT7
43 mucinous bronchioloalveolar adenocarcinoma 10.4 KRT20 KRT7
44 intracystic papillary adenoma 10.4 ERBB2 PGR
45 progesterone-receptor negative breast cancer 10.4 ERBB2 PGR
46 bladder adenocarcinoma 10.4 KRT20 KRT7
47 bile duct cystadenocarcinoma 10.4 KRT20 KRT7
48 basal cell carcinoma, infundibulocystic 10.4 KRT14 KRT20
49 intratubular embryonal carcinoma 10.4 KRT20 KRT7
50 proliferating trichilemmal cyst 10.4 KRT7 KRT8

Graphical network of the top 20 diseases related to Sweat Gland Cancer:



Diseases related to Sweat Gland Cancer

Symptoms & Phenotypes for Sweat Gland Cancer

MGI Mouse Phenotypes related to Sweat Gland Cancer:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.91 KRT14 KRT5 KRT8 AR TP53 ERBB2
2 embryo MP:0005380 9.87 ESR1 KRT8 AR PGR DAND5 TP53
3 integument MP:0010771 9.86 KRT14 KRT5 AR MME PGR TP53
4 limbs/digits/tail MP:0005371 9.63 ESR1 KRT5 AR PGR TP53 ERBB2
5 neoplasm MP:0002006 9.43 KRT14 AR PGR TP53 ERBB2 ESR1
6 reproductive system MP:0005389 9.17 ESR1 KRT14 KRT8 AR PGR TP53

Drugs & Therapeutics for Sweat Gland Cancer

Drugs for Sweat Gland Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Antibodies Phase 2
3 Antibodies, Monoclonal Phase 2
4 Immunoglobulins Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Sweat Gland Cancer

Cochrane evidence based reviews: sweat gland neoplasms

Genetic Tests for Sweat Gland Cancer

Anatomical Context for Sweat Gland Cancer

MalaCards organs/tissues related to Sweat Gland Cancer:

38
Skin

Publications for Sweat Gland Cancer

Articles related to Sweat Gland Cancer:

# Title Authors Year
1
Neck sweat gland cancer hemorrhage. Case study. ( 23788972 )
2013

Variations for Sweat Gland Cancer

Expression for Sweat Gland Cancer

Search GEO for disease gene expression data for Sweat Gland Cancer.

Pathways for Sweat Gland Cancer

GO Terms for Sweat Gland Cancer

Cellular components related to Sweat Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.96 AR ERBB2 KRT14 KRT15 KRT20 KRT5
2 cytoplasm GO:0005737 9.9 AR ERBB2 ESR1 KRT14 KRT20 KRT5
3 keratin filament GO:0045095 9.26 KRT14 KRT5 KRT7 KRT8
4 intermediate filament GO:0005882 9.1 KRT14 KRT15 KRT20 KRT5 KRT7 KRT8

Biological processes related to Sweat Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 9.61 KRT14 KRT15 KRT5
2 mammary gland alveolus development GO:0060749 9.46 AR ESR1
3 steroid hormone mediated signaling pathway GO:0043401 9.43 AR ESR1 PGR
4 keratinization GO:0031424 9.43 KRT14 KRT15 KRT20 KRT5 KRT7 KRT8
5 replicative senescence GO:0090399 9.4 MME TP53
6 positive regulation of transcription by RNA polymerase III GO:0045945 9.37 AR ERBB2
7 hemidesmosome assembly GO:0031581 9.32 KRT14 KRT5
8 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 9.16 AR PGR
9 cornification GO:0070268 9.1 KRT14 KRT15 KRT20 KRT5 KRT7 KRT8

Molecular functions related to Sweat Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.83 AR ESR1 MME PGR TP53
2 enzyme binding GO:0019899 9.71 AR ESR1 PGR TP53
3 ATPase binding GO:0051117 9.54 AR ESR1 PGR
4 scaffold protein binding GO:0097110 9.5 KRT15 KRT5 KRT8
5 steroid hormone receptor activity GO:0003707 9.43 AR ESR1 PGR
6 nuclear receptor activity GO:0004879 9.33 AR ESR1 PGR
7 steroid binding GO:0005496 9.13 AR ESR1 PGR
8 structural constituent of cytoskeleton GO:0005200 8.92 KRT14 KRT15 KRT20 KRT5

Sources for Sweat Gland Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....