MCID: SWT001
MIFTS: 59

Sweat Gland Carcinoma malady

Cancer diseases, Endocrine diseases categories

Summaries for Sweat Gland Carcinoma

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34MalaCards
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MalaCards: Sweat Gland Carcinoma, also known as malignant tumor of the sweat gland, is related to syringocystadenoma papilliferum and eccrine porocarcinoma. An important gene associated with Sweat Gland Carcinoma is S100B (S100 calcium binding protein B), and among its related pathways are TP53 network and EGFR Transactivation by Gastrin. The compounds pd158780 and iressa have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and lymph node, and related mouse phenotypes are pigmentation and limbs/digits/tail.

Aliases & Classifications for Sweat Gland Carcinoma

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9Disease Ontology, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

sweat gland carcinoma 9
malignant tumor of the sweat gland 9
malignant neoplasm of sweat gland 9
carcinoma of the sweat gland 9
sweat gland adenocarcinoma 63
tumor of the sweat gland 9
neoplasm of sweat gland 9
sweat gland tumor nos 9
sweat gland neoplasm 9
sweat gland cancer 9
sweat gland tumor 9


Related Diseases for Sweat Gland Carcinoma

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18GeneCards, 19GeneDecks
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Diseases related to Sweat Gland Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 183)
idRelated DiseaseScoreTop Affiliating Genes
1syringocystadenoma papilliferum30.5PIP
2eccrine porocarcinoma30.4MUC1
3hidradenoma30.4MUC1, PIP
4myoepithelioma30.3KRT14, S100B, S100A1, ACTC1, TP63
5melanoma30.1KRT14, S100B, S100A1, PCNA, ACTC1, TP53
6papillary carcinoma30.0KRT20, KRT7, KRT14, ERBB2, S100A1, ACTC1
7mucoepidermoid carcinoma30.0EGFR, KRT13, KRT7, KRT14, S100A1, PCNA
8adenocarcinoma29.5EGF, EGFR, KRT13, KRT20, KRT7, KRT1
9apocrine sweat gland neoplasm10.3
10malignant acrospiroma10.3
11spiradenoma10.3
12eccrine sweat gland cancer10.3
13eccrine papillary adenoma10.2
14apocrine adenoma10.2
15hypercalcemia10.2
16adenoiditis10.2
17primary biliary cirrhosis10.2
18mastitis10.2
19sarcoidosis10.2
20acrospiroma10.2
21eccrine acrospiroma10.1
22nodular hidradenoma10.1
23dermal eccrine cylindroma10.1
24gemistocytic astrocytoma10.1S100B
25hidrocystoma10.1PIP
26epithelial-myoepithelial carcinoma10.1KRT14
27inverted papilloma10.1KRT20
28rosai-dorfman disease10.1S100B
29glomus tumor10.1S100A1, ACTC1
30metanephric adenoma10.1KRT7
31langerhans-cell histiocytosis10.1S100B, S100A1
32supernumerary nipples10.1KRT20, PIP
33nephrogenic adenoma10.1KRT7, S100A1
34cystadenocarcinoma10.1MUC5AC, MUC1
35giant cell glioblastoma10.1EGFR
36fibrous meningioma10.1S100B, MUC1
37anaplastic ependymoma10.1S100B, MUC1
38choroid plexus papilloma10.1S100B, MUC1
39cystadenoma10.1KRT7
40granular cell tumor10.1S100B, S100A1
41secretory meningioma10.1KRT7, MUC1
42bladder adenocarcinoma10.1KRT20, KRT7
43breast fibroadenoma10.1PGR
44fibrous histiocytoma10.1S100B, ACTC1
45ovarian brenner tumor10.1KRT20, KRT7
46papilloma10.1KRT14, MUC5AC
47leiomyomatosis10.1PGR
48cutaneous fibrous histiocytoma10.1S100B, S100A1, ACTC1
49oxyphilic adenoma10.1KRT7, S100A1
50perineurioma10.1S100B, MUC1

Graphical network of the top 20 diseases related to Sweat Gland Carcinoma:



Diseases related to sweat gland carcinoma

Symptoms for Sweat Gland Carcinoma

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Drugs & Therapeutics for Sweat Gland Carcinoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Sweat Gland Carcinoma

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Anatomical Context for Sweat Gland Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Sweat Gland Carcinoma:

34
Breast, Skin, Lymph node, Lung, Bone, Kidney, Salivary gland

Animal Models for Sweat Gland Carcinoma or affiliated genes

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38MGI
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Publications for Sweat Gland Carcinoma

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53PubMed
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Articles related to Sweat Gland Carcinoma:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
Aggressiveness of poorly differentiated sweat gland carcinoma in kidney transplant recipient. (23829827)
2013
2
Mucin-producing sweat gland carcinoma of the eyelid: diagnostic and prognostic considerations. (23218693)
2013
3
Apocrine sweat gland carcinoma: initial evaluation, staging, and response monitoring using 18F-FDG PET/CT. (23377411)
2013
4
Endocrine mucin producing sweat gland carcinoma: a clinicopathological analysis of three cases. (22935981)
2012
5
Clinicopathologic characteristics of 12 patients with vulvar sweat gland carcinoma. (20606537)
2010
6
Sweat gland carcinoma - a case report. (21661469)
2010
7
Sweat gland carcinoma. (19116525)
2009
8
Endocrine mucin-producing sweat gland carcinoma: report of a case and review of the literature. (17177942)
2006
9
Sweat gland carcinoma with lung metastases. (17998708)
2006
10
Endocrine mucin-producing sweat gland carcinoma: twelve new cases suggest that it is a precursor of some invasive mucinous carcinomas. (16160476)
2005
11
Treatment of synchronous mucinous carcinoma and endocrine mucin-producing sweat gland carcinoma with Mohs' micrographic surgery. (15841644)
2005
12
Sweat gland carcinoma. (14964551)
2004
13
Recurrent polymorphous sweat gland carcinoma of the skin. (12063490)
2002
14
Histiocytoid variant of eccrine sweat gland carcinoma of the eyelid and orbit: report of five cases. (11874761)
2002
15
Facial sweat gland carcinoma metastasizing to neck nodes: a diagnostic and therapeutic challenge. (11735822)
2001
16
Metastatic sweat gland carcinoma. (11762625)
2001
17
Apocrine sweat gland carcinoma. (11339615)
2001
18
Malignant apocrine sweat gland carcinoma of the caruncle. (12045959)
2000
19
Sweat gland carcinoma with multiple local recurrences: a case report. (10655575)
1999
20
Epidermal growth factor, estrogen, and progesterone receptor expression in primary sweat gland carcinomas and primary and metastatic mammary carcinomas. (10463481)
1999
21
Sweat gland carcinoma: a clinicopathologic analysis of an expanded series in a single institution. (9727435)
1998
22
Endocrine mucin-producing sweat gland carcinoma: a cutaneous neoplasm analogous to solid papillary carcinoma of breast. (9414195)
1997
23
Sweat gland carcinoma. (9149787)
1997
24
Sweat gland carcinoma in a human immunodeficiency virus-infected patient. (7539911)
1995
25
Sweat gland carcinoma of the vulva. (7618462)
1995
26
Prognostic value of immunohistochemical staining for proliferating cell nuclear antigen, p53, and c-erbB-2 in sebaceous gland carcinoma and sweat gland carcinoma: comparison with histopathological parameter. (7909154)
1994
27
A case of ductal sweat gland carcinoma connected to syringocystadenoma papilliferum arising in nevus sebaceus. (7699123)
1994
28
Giant primary mucinous sweat gland carcinoma of the scalp. (8403482)
1993
29
Sweat gland carcinoma with mucinous and infiltrating duct-like patterns. (1331212)
1992
30
Sweat gland carcinoma ex eccrine spiradenoma. (2847574)
1987
31
Mucinous (adenocystic) sweat gland carcinoma of the great toe. (2833541)
1987
32
Inguinal sweat gland carcinoma with choriocarcinomatous differentiation. (2425551)
1986
33
Axillary sweat gland carcinoma versus amelanotic malignant melanoma. (4089996)
1985
34
Chemotherapy of metastatic sweat gland carcinoma. A retrospective review. (3909802)
1985
35
Extramammary Paget's disease. Arising in knee region in association with sweat gland carcinoma. (6205637)
1984
36
Metastasizing eccrine sweat gland carcinoma. Report of a case. (6721544)
1984
37
Sweat gland carcinoma with hypercalcemia. (7132372)
1982
38
Primary mucinous sweat gland carcinoma of the eyelid simulating metastatic carcinoma. (219696)
1979
39
Sustained complete remission of metastatic sweat gland carcinoma following regional hyperthermic perfusion. (660813)
1978
40
Metastatic sweat gland carcinoma. (703462)
1978
41
Sweat gland carcinoma: a clinico-pathological reappraisal. (1249938)
1976
42
Sweat gland carcinoma. Report of a case in an unusual location and review of literature. (4823258)
1974
43
Sweat gland carcinoma of the hand. (4825405)
1974
44
Sweat gland carcinoma arising in irradiated skin. (5011405)
1972
45
Sweat gland carcinoma: a clinico-pathologic study of 83 patients. (5100098)
1971
46
Apocrine sweat gland carcinoma. Report of a case. (5476740)
1970
47
Intracranial metastasis of sweat gland carcinoma. Case report. (4288759)
1966
48
APOCRINE GLAND CARCINOMA (SWEAT GLAND CARCINOMA) OF THE BREAST. (14119212)
1964
49
Metastasizing sweat-gland carcinoma; notes on the surgical therapy. (13636656)
1959
50
Sweat-gland carcinoma of eyelid. (14430109)
1959

Variations for Sweat Gland Carcinoma

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Expression for genes affiliated with Sweat Gland Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sweat Gland Carcinoma

Search GEO for disease gene expression data for Sweat Gland Carcinoma.

Pathways for genes affiliated with Sweat Gland Carcinoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 5Cell Signaling Technology, 61Thomson Reuters, 31KEGG, 55R&D Systems, 62Tocris Bioscience, 54QIAGEN, 52PharmGKB, 58SinoBiological
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Pathways related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9TP63, TP53
2
Show member pathways
EGFR-dependent Endothelin signaling events39
9.8EGF, EGFR
39.5ERBB2, EGFR, EGF
4
Show member pathways
9.5ERBB2, EGFR, EGF
59.5ERBB2, EGFR, EGF
6
Show member pathways
Development Ligand independent activation of ESR1 and ESR261
9.5EGF, EGFR, ERBB2
7
Show member pathways
Translation Non genomic rapid action of Androgen Receptor61
9.5EGF, EGFR, ERBB2
89.5EGF, EGFR, ERBB2
99.5TP53, ERBB2, EGFR
10
Show member pathways
9.5TP53, ERBB2, EGFR
11
Show member pathways
9.5EGFR, ERBB2, TP53
12
Show member pathways
Delta-Notch Signaling Pathway39
Notch Signaling Pathway39
9.4TP53, EGFR, EGF
13
Show member pathways
9.4TP53, EGFR, EGF
149.4EGF, EGFR, TP53
159.4EGF, EGFR, TP53
169.4EGFR, EGF, TP53
17
Show member pathways
Development ERBB family signaling61
Development GDNF family signaling61
9.3EGF, EGFR, ERBB2, MUC1
189.2TP63, TP53, ERBB2, EGFR
19
Show member pathways
9.2TP53, ERBB2, EGFR, EGF
20
Show member pathways
ErbB receptor signaling network39
ErbB signaling pathway39
9.2TP53, ERBB2, EGFR, EGF
219.2TP53, ERBB2, EGFR, EGF
22
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
9.2TP53, ERBB2, EGFR, EGF
23
Show member pathways
9.2EGF, EGFR, ERBB2, TP53
24
Show member pathways
Signaling Pathways in Glioblastoma39
9.2EGF, EGFR, ERBB2, TP53
25
Show member pathways
9.0PGR, S100B, ERBB2, EGFR, EGF
269.0EGFR, PCNA, TP53, TP63
278.9EGF, EGFR, ERBB2, MUC1, TP53
288.9KRT13, KRT7, KRT1, KRT14
29
Show member pathways
8.7PIP, TP53, ERBB2, EGFR, EGF
30
Show member pathways
8.7EGF, EGFR, ERBB2, TP53, PIP
31
Show member pathways
Signal transduction PTEN pathway61
8.6TP53, PCNA, ERBB2, EGFR, EGF
328.6TP53, PCNA, ERBB2, EGFR, EGF
33
Show member pathways
8.5EGF, EGFR, ERBB2, MUC1, TP53, PIP

Compounds for genes affiliated with Sweat Gland Carcinoma

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Sources:
46Novoseek, 62Tocris Bioscience, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB
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Compounds related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 143)
idCompoundScoreTop Affiliating Genes
1pd158780469.8ERBB2, EGFR, EGF
2iressa629.8EGFR, ERBB2, EGF
3ag 490629.8EGFR, ERBB2, EGF
4jnj 28871063 hydrochloride629.8EGF, EGFR, ERBB2
5ag 1478 hydrochloride629.8ERBB2, EGFR, EGF
6pertuzumab46 52 1211.7ERBB2, EGF, EGFR
7eosin469.7S100B, MUC1, PCNA
82-methoxyethanol469.7ACTC1, TP63, KRT14, S100A1
9pki-166469.6EGFR, EGF, ERBB2
10capecitabine46 52 1211.6EGFR, EGF, ERBB2, PGR
11lapatinib46 52 1211.5EGFR, ERBB2, PGR, EGF
12s 100469.5S100B, MUC1, ACTC1
13taxane469.5TP53, PGR, ERBB2, EGFR
144-hydroxytamoxifen469.4EGFR, EGF, PGR, ERBB2, S100B
15trastuzumab46 52 1211.3PGR, MUC1, EGF, EGFR, ERBB2
16progestin469.3EGF, EGFR, ERBB2, MUC1, PGR
17leucovorin46 52 1211.2EGFR, EGF, PGR, ERBB2
18geldanamycin46 52 62 1212.2EGF, ERBB2, EGFR, TP53, PGR
19fulvestrant46 52 30 1212.1ERBB2, EGF, EGFR, PCNA, PGR
20bromodeoxyuridine469.1TP63, EGF, KRT1, KRT14, PCNA, S100B
21biotin46 25 1211.0MUC1, S100A1, ACTC1, PCNA, ERBB2, KRT1
22reticulin468.9KRT7, S100B, PCNA, ACTC1, MUC1
23egcg468.9EGFR, ERBB2, PCNA, EGF, TP53
24gemcitabine46 52 1210.8EGF, PCNA, EGFR, TP53, ERBB2, MUC1
25proline468.6S100B, KRT14, MUC5AC, KRT1, KRT13, TP53
26paclitaxel46 52 1210.5EGFR, S100B, PCNA, PGR, TP53, EGF
27doxorubicin46 52 1210.3TP63, TP53, PGR, ERBB2, KRT20, EGFR
28cisplatin46 52 62 1211.3ERBB2, TP63, TP53, MUC1, PCNA, EGF
29dexamethasone46 52 30 1211.2PGR, MUC1, ERBB2, EGF, S100B, PCNA
30methotrexate52 46 1210.1MUC1, PGR, MUC5AC, PCNA, ERBB2, KRT7
31steroid468.1ERBB2, KRT1, EGF, ACTC1, S100B, MUC5AC
32retinoid468.0EGFR, KRT7, KRT1, MUC5AC, PGR, TP53
335fluorouracil468.0PGR, PCNA, TP53, ERBB2, EGFR, EGF
34formaldehyde46 259.0KRT7, KRT20, ERBB2, S100B, ACTC1, MUC1
35iron46 258.9ACTC1, S100A1, S100B, KRT14, KRT20, KRT7
36arginine467.9TP63, PCNA, S100B, KRT7, ERBB2, KRT14
37cysteine467.9EGF, S100B, MUC1, PGR, KRT14, MUC5AC
38tamoxifen46 52 30 1210.9PIP, TP53, PGR, MUC1, EGF, EGFR
39serine467.8S100B, ERBB2, EGFR, MUC1, EGF, KRT1
40calcium46 52 25 1210.6EGF, TP63, KRT13, KRT1, KRT14, S100A1
41mucicarmine467.4ACTC1, S100A1, S100B, KRT14, KRT7, KRT20
42b 723467.2PIP, TP63, MUC1, ACTC1, KRT20, PCNA
43hematoxylin466.6KRT20, TP63, MUC5AC, KRT7, KRT1, KRT14
44vegf466.4EGF, EGFR, KRT20, KRT7, ERBB2, S100B
45tyrosine466.1ERBB2, KRT20, MUC5AC, MUC1, TP63, KRT1
46retinoic acid46 256.6S100A1, PCNA, ACTC1, MUC5AC, MUC1, PGR
47testosterone46 62 25 128.6MUC5AC, MUC1, PGR, TP63, PIP, ACTC1
48paraffin464.6KRT14, ERBB2, S100B, S100A1, PCNA, ACTC1
49progesterone46 30 62 25 128.6ERBB2, KRT14, KRT1, KRT7, KRT20, EGFR
50estrogen464.5EGF, EGFR, KRT20, PGR, TP53, TP63

GO Terms for genes affiliated with Sweat Gland Carcinoma

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17Gene Ontology
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Cellular components related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.3MUC1, TP53, TP63
2apical plasma membraneGO:0163249.2PIP, MUC1, ERBB2, EGFR
3keratin filamentGO:0450959.0KRT14, KRT1, KRT7, KRT13
4intermediate filamentGO:0058828.8KRT20, KRT7, KRT14
5extracellular spaceGO:0056158.6PIP, ACTC1, S100B, KRT1, EGFR, EGF
6extracellular vesicular exosomeGO:0700627.7EGF, PIP, MUC1, MUC5AC, ACTC1, PCNA
7cytoplasmGO:0057376.4TP63, TP53, MUC1, ACTC1, PCNA, S100B

Biological processes related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:03157110.0TP53, TP63
2regulation of angiogenesisGO:04576510.0KRT1, ERBB2
3response to X-rayGO:0101659.9TP53, TP63
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.9MUC1, TP53, TP63
5positive regulation of catenin import into nucleusGO:0354139.9EGF, EGFR
6positive regulation of MAP kinase activityGO:0434069.7EGF, EGFR, ERBB2
7positive regulation of phosphorylationGO:0423279.7EGF, EGFR
8peptidyl-tyrosine phosphorylationGO:0181089.7ERBB2, EGFR, EGF
9negative regulation of apoptotic processGO:0430669.3TP63, TP53, ACTC1, EGFR
10fibroblast growth factor receptor signaling pathwayGO:0085439.2EGF, EGFR, ERBB2
11phosphatidylinositol-mediated signalingGO:0480159.2PCNA, ERBB2, EGFR, EGF
12cell proliferationGO:0082839.0TP53, PCNA, S100B, ERBB2, EGFR

Molecular functions related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.9EGFR, ERBB2
2S100 protein bindingGO:0445489.8S100B, S100A1
3p53 bindingGO:0020399.6TP63, TP53, MUC1
4receptor signaling protein tyrosine kinase activityGO:0047169.5EGFR, ERBB2
5protein phosphatase bindingGO:0199039.4EGFR, ERBB2, TP53
6identical protein bindingGO:0428028.2EGFR, TP63, TP53, PCNA, S100A1, S100B
7protein bindingGO:0055155.4S100A1, PCNA, MUC1, PGR, TP53, TP63

Products for genes affiliated with Sweat Gland Carcinoma

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Sources for Sweat Gland Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet