MCID: SWT001
MIFTS: 49

Sweat Gland Carcinoma malady

Endocrine, Cancer categories

Summaries for Sweat Gland Carcinoma

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33MalaCards
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MalaCards: Sweat Gland Carcinoma, also known as malignant tumor of the sweat gland, is related to syringocystadenoma papilliferum and eccrine porocarcinoma. An important gene associated with Sweat Gland Carcinoma is KRT1 (keratin 1), and among its related pathways are Glioma and Apoptosis Modulation and Signaling. The compounds adriamycin and jnj 28871063 hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and lymph node, and related mouse phenotypes are muscle and endocrine/exocrine gland.

Aliases & Classifications for Sweat Gland Carcinoma

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Endocrine


Aliases & Descriptions:

sweat gland carcinoma 8
malignant tumor of the sweat gland 8
malignant neoplasm of sweat gland 8
carcinoma of the sweat gland 8
sweat gland adenocarcinoma 61
sweat gland cancer 8


External Ids:

Disease Ontology8 DOID:5667, DOID:2095
NCIt40 C6938, C4810

Related Diseases for Sweat Gland Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Sweat Gland Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 235)
idRelated DiseaseScoreTop Affiliating Genes
1syringocystadenoma papilliferum30.2PIP
2eccrine porocarcinoma30.2MUC1
3syringoma30.2KRT14, KRT1, MUC1, S100A1, S100B
4mammary paget's disease30.2ERBB2, KRT20, KRT7, PGR, MUC1
5papillary carcinoma30.1TP63, ERBB2, ACTC1, KRT20, KRT7, KRT14
6mucoepidermoid carcinoma30.1TP63, ACTC1, KRT13, KRT7, KRT14, PCNA
7adenoid cystic carcinoma30.1TP63, ERBB2, ACTC1, KRT8, KRT20, KRT7
8adenocarcinoma30.1TP53, TP63, ERBB2, ACTC1, KRT8, KRT13
9eye carcinoma10.6
10eyelid carcinoma10.6
11sweat gland disease10.4
12breast apocrine carcinoma10.4
13small cell carcinoma10.3
14malignant acrospiroma10.3
15spiradenoma10.3
16sweat gland neoplasm10.3
17paget disease, extramammary10.3
18hidradenocarcinoma10.2
19bone carcinoma10.1
20amelanotic melanoma10.1
21penis paget's disease10.1
22primary biliary cirrhosis10.1
23malignant spiradenoma10.1
24breast papillary carcinoma10.1
25hypercalcemia10.1
26anal gland neoplasm10.1
27vulva adenocarcinoma10.1
28vulvar disease10.1
29acrospiroma10.1
30keratosis10.0KRT1
31hemangioma10.0ACTC1
32hidrocystoma10.0PIP
33gemistocytic astrocytoma10.0S100B
34epithelial-myoepithelial carcinoma10.0KRT14
35desmoid tumor10.0ACTC1
36cystadenoma10.0KRT7
37tuberous sclerosis10.0S100B
38mixed cell type cancer10.0KRT7
39pilocytic astrocytoma10.0S100B
40histiocytosis10.0S100B
41epidermolysis bullosa10.0KRT14
42pituitary adenoma10.0PCNA
43cervical intraepithelial neoplasia10.0KRT8
44keratoacanthoma10.0PCNA
45lichen planus10.0KRT13, KRT1
46ganglioglioma10.0S100B
47otitis media10.0MUC5AC
48asthma10.0MUC5AC
49pulmonary fibrosis10.0KRT8
50hepatoblastoma10.0KRT7

Graphical network of the top 20 diseases related to Sweat Gland Carcinoma:



Diseases related to sweat gland carcinoma

Clinical Features for Sweat Gland Carcinoma

Drugs & Therapeutics for Sweat Gland Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Sweat Gland Carcinoma

Drug clinical trials:

Search ClinicalTrials for Sweat Gland Carcinoma

Search NIH Clinical Center for Sweat Gland Carcinoma

Search CenterWatch for Sweat Gland Carcinoma

Genetic Tests for Sweat Gland Carcinoma

Anatomical Context for Sweat Gland Carcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Sweat Gland Carcinoma:

33
Skin, Kidney, Lymph node, Lung, Salivary gland, Breast

Animal Models for Sweat Gland Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Sweat Gland Carcinoma

Sources:
51PubMed
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Articles related to Sweat Gland Carcinoma:

(show top 50)    (show all 121)
idTitleAuthorsYear
1
Mucin-producing sweat gland carcinoma of the eyelid: diagnostic and prognostic considerations. (23218693)
2013
2
Late lung metastasis of a primary eccrine sweat gland carcinoma 10 years after initial surgical treatment: the first clinical documentation. (23710393)
2013
3
Recurrent endocrine mucin-producing sweat gland carcinoma in the eyelid. (23582005)
2013
4
A case of endocrine mucin-producing sweat gland carcinoma. (22524664)
2012
5
Primary adenoid cystic carcinoma of sweat glands in vulva: report of an unusual case and review of the literature. (21651649)
2011
6
Endocrine mucin-producing sweat gland carcinoma of the eyelid. (18356733)
2008
7
Apocrine (cutaneous) sweat gland carcinoma of axilla with signet ring cells: a diagnostic dilemma on fine-needle aspiration cytology. (18773442)
2008
8
Recurrent endocrine mucin-producing sweat gland carcinoma. (18022131)
2007
9
Treatment of synchronous mucinous carcinoma and endocrine mucin-producing sweat gland carcinoma with Mohs' micrographic surgery. (15841644)
2005
10
Small cell sweat gland carcinoma of childhood. (16311358)
2005
11
Sentinel lymph node analysis in patients with sweat gland carcinoma. (12712484)
2003
12
Recurrent polymorphous sweat gland carcinoma of the skin. (12063490)
2002
13
Apocrine sweat gland carcinoma. (11339615)
2001
14
Malignant apocrine sweat gland carcinoma of the caruncle. (12045959)
2000
15
Eccrine sweat gland carcinoma: a case report and review of diagnosis and treatment. (10860232)
2000
16
Sweat gland carcinoma with multiple local recurrences: a case report. (10655575)
1999
17
Epidermal growth factor, estrogen, and progesterone receptor expression in primary sweat gland carcinomas and primary and metastatic mammary carcinomas. (10463481)
1999
18
Homologous carcinomas of the breasts, skin, and salivary glands. A histologic and immunohistochemical comparison of ductal mammary carcinoma, ductal sweat gland carcinoma, and salivary duct carcinoma. (9426521)
1998
19
Sweat gland carcinoma of the foot: a review and patient report. (9827961)
1998
20
Follow-up of sweat gland carcinoma by FDG-PET imaging. (9442968)
1998
21
Endocrine mucin-producing sweat gland carcinoma: a cutaneous neoplasm analogous to solid papillary carcinoma of breast. (9414195)
1997
22
Sweat gland carcinoma. (9149787)
1997
23
Sweat gland carcinoma. Case report and review of the literature. (9107287)
1997
24
Sweat gland carcinoma diagnosed by fine needle aspiration (FNA). (8833877)
1996
25
Sweat gland carcinoma with metastases to the skin: response to 5-fluorouracil chemotherapy. (7796614)
1995
26
Sweat gland carcinoma in a patient with sarcoidosis and primary biliary cirrhosis. (8075455)
1994
27
Giant primary mucinous sweat gland carcinoma of the scalp. (8403482)
1993
28
Sweat gland carcinoma: an easily confused skin malignancy. (8334563)
1993
29
Sweat gland carcinoma with mucinous and infiltrating duct-like patterns. (1331212)
1992
30
Cytokeratin expression in mucinous sweat gland carcinomas: an immunohistochemical analysis of four cases. (1380481)
1992
31
Spinal metastasis of sweat gland carcinoma. A case report. (1750011)
1991
32
Metastatic eccrine sweat gland carcinoma: case report. (3243367)
1988
33
Sweat gland carcinoma with bone and visceral metastases. Prolonged complete remission lasting 16 months as a result of chemotherapy. (3594354)
1987
34
Inguinal sweat gland carcinoma with choriocarcinomatous differentiation. (2425551)
1986
35
Axillary sweat gland carcinoma versus amelanotic malignant melanoma. (4089996)
1985
36
Metastasizing eccrine sweat gland carcinoma. Report of a case. (6721544)
1984
37
Sweat gland carcinoma with hypercalcemia. (7132372)
1982
38
Sweat gland carcinoma. (287812)
1979
39
Metastatic sweat gland carcinoma. (703462)
1978
40
Sweat gland carcinoma: a clinico-pathological reappraisal. (1249938)
1976
41
Sweat gland carcinoma. Report of a case in an unusual location and review of literature. (4823258)
1974
42
Sweat gland carcinoma arising in irradiated skin. (5011405)
1972
43
Sweat gland carcinoma: a clinico-pathologic study of 83 patients. (5100098)
1971
44
Sweat gland carcinoma. (5560851)
1971
45
Apocrine sweat gland carcinoma. Report of a case. (5476740)
1970
46
Sweat-gland carcinoma. A clinicopathologic problem. (4164856)
1967
47
VERY LATE RECURRENCE OF A PREVIOUSLY EXCISED SWEAT GLAND CARCINOMA: CASE REPORT WITH REVIEW OF THE LITERATURE. (14316199)
1965
48
Sweat gland carcinoma. (13327847)
1956
49
Sweat-gland carcinoma. (13261057)
1955
50
Apocrine tissue, chronic cystic mastitis and sweat gland carcinoma of the breast. (18104212)
1949

Genetic Variations for Sweat Gland Carcinoma

Expression for genes affiliated with Sweat Gland Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Sweat Gland Carcinoma

Search GEO for disease gene expression data for Sweat Gland Carcinoma.

Pathways for genes affiliated with Sweat Gland Carcinoma

Sources:
30KEGG, 38NCBI BioSystems Database, 60Tocris Bioscience, 54Reactome, 12EMD Millipore, 53R&D Systems, 52QIAGEN, 50PharmGKB, 4Cell Signaling Technology, 56SinoBiological
See all sources

Pathways related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1TP53
2
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9.8TP53, TP63
3
Hide members
9.8ERBB2, TP53
49.5ERBB2, EGFR, EGF
5
Hide members
9.5EGF, EGFR, ERBB2
6
Transcription Androgen Receptor nuclear signaling
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9.5EGF, EGFR, ERBB2
79.5TP53, ERBB2, EGFR
8
Hide members
9.4TP53, EGFR, EGF
99.4EGF, EGFR, TP53
10
Hide members
9.3EGF, EGFR, MUC1, ERBB2
119.2TP53, TP63, ERBB2, EGFR
12
Hide members
9.1TP53, ERBB2, EGFR, EGF
13
Hide members
9.1EGF, EGFR, ERBB2, TP53
14
Hide members
9.1TP53, ERBB2, EGFR, EGF
15
Hide members
9.1TP53, ERBB2, EGF, PIP
16
Hide members
9.0ERBB2, PGR, EGFR, EGF, S100B
179.0KRT7, KRT13, KRT8, ACTC1
189.0EGFR, PCNA, TP63, TP53
198.9EGF, EGFR, MUC1, ERBB2, TP53
208.8KRT8, KRT13, KRT7, KRT14, KRT1
218.7EGF, EGFR, KRT7, KRT8
22
Hide members
8.7PIP, EGF, EGFR, ERBB2, TP53
238.6EGF, EGFR, PCNA, ERBB2, TP53
24
Hide members
8.6EGF, EGFR, PCNA, ERBB2, TP53

Compounds for genes affiliated with Sweat Gland Carcinoma

Sources:
45Novoseek, 60Tocris Bioscience, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB
See all sources

Compounds related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1adriamycin459.8MUC1, PGR, KRT8
2jnj 28871063 hydrochloride609.8EGF, EGFR, ERBB2
3ag 490609.8EGF, EGFR, ERBB2
4s 100459.8ACTC1, MUC1, S100B
5ag 1478 hydrochloride609.8EGF, EGFR, ERBB2
6pd158780459.8ERBB2, EGFR, EGF
7iressa609.8ERBB2, EGFR, EGF
8pertuzumab45 50 1111.7EGF, EGFR, ERBB2
92-methoxyethanol459.7S100A1, KRT14, ACTC1, TP63
10capecitabine45 50 1111.6ERBB2, PGR, EGFR, EGF
11lapatinib45 50 1111.6ERBB2, PGR, EGFR, EGF
12pki-166459.6EGF, EGFR, ERBB2
13taxane459.5EGFR, PGR, ERBB2, TP53
14eosin459.5S100B, MUC1, PCNA
154-hydroxytamoxifen459.4S100B, EGF, EGFR, PGR, ERBB2
16trastuzumab45 50 1111.4EGF, EGFR, MUC1, PGR, ERBB2
17dexamethasone45 50 29 1112.4PCNA, MUC5AC, S100B
18progestin459.3EGF, EGFR, MUC1, PGR, ERBB2
19geldanamycin45 50 60 1112.2EGF, EGFR, PGR, ERBB2, TP53
20leucovorin45 50 1111.1EGF, EGFR, PGR, ERBB2
21fulvestrant45 50 29 1112.1EGF, EGFR, PCNA, PGR, ERBB2
22agar459.1EGF, EGFR, MUC1, PGR, KRT8, ERBB2
23biotin45 11 2410.9S100A1, MUC1, PCNA, KRT1, ACTC1, ERBB2
24bromodeoxyuridine458.9S100B, EGF, PCNA, KRT1, KRT14, KRT8
25reticulin458.9S100B, MUC1, PCNA, KRT7, ACTC1
26paclitaxel45 50 1110.8S100B, EGF, EGFR, PGR, KRT8, ERBB2
27gemcitabine45 50 1110.8EGF, EGFR, MUC1, PCNA, ERBB2, TP53
28steroid458.6PIP, EGF, MUC5AC, KRT1, KRT8, ACTC1
29matrigel458.5EGF, MUC1, KRT7, KRT8, ACTC1, TP63
30doxorubicin45 50 1110.2EGF, EGFR, PGR, KRT20, KRT8, ERBB2
31iron45 249.1S100B, S100A1, KRT14, KRT7, KRT20, KRT8
32methotrexate45 50 1110.1MUC5AC, MUC1, PCNA, PGR, KRT7, ERBB2
33formaldehyde45 249.0S100B, MUC1, PCNA, KRT7, KRT20, ACTC1
34cisplatin45 50 60 1111.0EGF, EGFR, MUC1, PCNA, KRT14, KRT8
355fluorouracil457.9EGF, EGFR, MUC5AC, MUC1, PCNA, PGR
36retinoid457.8EGFR, MUC5AC, PGR, KRT1, KRT14, KRT7
37arginine457.7S100B, PCNA, KRT1, KRT14, KRT7, ERBB2
38cysteine457.7S100B, S100A1, EGF, MUC5AC, MUC1, PCNA
39tamoxifen45 50 29 1110.7PIP, EGF, EGFR, MUC1, PCNA, PGR
40serine457.5S100B, EGF, EGFR, MUC5AC, MUC1, KRT1
41mucicarmine457.5TP63, ACTC1, KRT20, KRT7, KRT14, MUC1
42hematoxylin457.2TP63, ACTC1, KRT8, KRT20, KRT7, KRT14
43b 723457.0PIP, S100A1, S100B, MUC1, PCNA, KRT7
44calcium45 50 11 249.9S100B, S100A1, EGF, MUC5AC, MUC1, KRT1
45vegf456.2ACTC1, KRT8, KRT20, KRT7, PGR, PCNA
46tyrosine455.9MUC1, MUC5AC, EGFR, EGF, S100A1, S100B
47testosterone45 60 11 248.4KRT8, KRT20, KRT7, KRT1, PGR, PCNA
48retinoic acid45 246.3KRT14, KRT1, PGR, PCNA, MUC1, MUC5AC
49paraffin454.4TP53, TP63, ERBB2, ACTC1, KRT8, KRT13
50progesterone45 60 29 11 248.3TP53, PIP, S100A1, S100B, EGF, EGFR

GO Terms for genes affiliated with Sweat Gland Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.6TP53, TP63, MUC1
2keratin filamentGO:0450958.8KRT8, KRT13, KRT7, KRT14, KRT1
3intermediate filamentGO:0058828.6KRT14, KRT7, KRT20, KRT8
4cytoplasmGO:0057376.2S100B, EGFR, MUC1, PCNA, KRT14, KRT7

Biological processes related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of catenin import into nucleusGO:0354139.8EGFR, EGF
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.7TP53, TP63, MUC1
3mitotic G1 DNA damage checkpointGO:0315719.5TP53, TP63
4positive regulation of MAP kinase activityGO:0434069.4ERBB2, EGFR, EGF
5phosphatidylinositol-mediated signalingGO:0480159.1ERBB2, PCNA, EGFR, EGF
6cell proliferationGO:0082838.7S100B, EGFR, PCNA, ERBB2, TP53

Molecular functions related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.9ERBB2, EGFR
2receptor signaling protein tyrosine kinase activityGO:0047169.8ERBB2, EGFR
3p53 bindingGO:0020399.6MUC1, TP63, TP53
4S100 protein bindingGO:0445489.5S100A1, S100B
5structural molecule activityGO:0051988.9KRT8, KRT13, KRT7, KRT1
6identical protein bindingGO:0428028.1TP53, S100B, S100A1, EGFR, PCNA, ERBB2
7protein bindingGO:0055155.3PCNA, MUC1, EGFR, EGF, S100A1, S100B

Products for genes affiliated with Sweat Gland Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sweat Gland Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet