MCID: SWT001
MIFTS: 56

Sweat Gland Carcinoma malady

Endocrine diseases, Cancer diseases categories

Summaries for Sweat Gland Carcinoma

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MalaCards: Sweat Gland Carcinoma, also known as malignant tumor of the sweat gland, is related to syringocystadenoma papilliferum and eccrine porocarcinoma. An important gene associated with Sweat Gland Carcinoma is KRT1 (keratin 1), and among its related pathways are Glioma and Apoptosis Modulation and Signaling. The compounds adriamycin and jnj 28871063 hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and lymph node, and related mouse phenotypes are muscle and endocrine/exocrine gland.

Aliases & Classifications for Sweat Gland Carcinoma

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

sweat gland carcinoma 8
malignant tumor of the sweat gland 8
malignant neoplasm of sweat gland 8
carcinoma of the sweat gland 8
sweat gland adenocarcinoma 60
tumor of the sweat gland 8
neoplasm of sweat gland 8
sweat gland tumor nos 8
sweat gland neoplasm 8
sweat gland cancer 8
sweat gland tumor 8


Related Diseases for Sweat Gland Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Sweat Gland Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 240)
idRelated DiseaseScoreTop Affiliating Genes
1syringocystadenoma papilliferum30.1PIP
2eccrine porocarcinoma30.1MUC1
3smooth muscle tumor30.1ACTC1, PGR, PCNA, S100A1, S100B
4hidradenoma30.1MUC1, PIP
5mammary paget's disease30.1ERBB2, KRT20, KRT7, PGR, MUC1
6myoepithelioma30.1TP63, ACTC1, KRT14, S100A1, S100B
7melanoma30.1TP53, TP63, ACTC1, KRT8, KRT14, PCNA
8papillary carcinoma30.1TP63, ERBB2, ACTC1, KRT20, KRT7, KRT14
9mucoepidermoid carcinoma30.1TP63, ACTC1, KRT13, KRT7, KRT14, PCNA
10adenoid cystic carcinoma30.1TP63, ERBB2, ACTC1, KRT8, KRT20, KRT7
11adenocarcinoma30.0TP53, TP63, ERBB2, ACTC1, KRT8, KRT13
12sweat gland disease10.4
13apocrine sweat gland neoplasm10.4
14breast apocrine carcinoma10.4
15small cell carcinoma10.3
16malignant acrospiroma10.3
17spiradenoma10.3
18eccrine sweat gland cancer10.3
19hidradenocarcinoma10.1
20eccrine papillary adenoma10.1
21apocrine adenoma10.1
22bone carcinoma10.1
23amelanotic melanoma10.1
24penis paget's disease10.1
25primary biliary cirrhosis10.1
26malignant spiradenoma10.1
27breast papillary carcinoma10.1
28hypercalcemia10.1
29adenoiditis10.1
30breast mucinous carcinoma10.1
31mastitis10.1
32sarcoidosis10.1
33skin disease10.1
34vulva adenocarcinoma10.1
35vulvar disease10.1
36eccrine acrospiroma10.1
37nodular hidradenoma10.1
38dermal eccrine cylindroma10.1
39keratosis10.0KRT1
40hemangioma10.0ACTC1
41hidrocystoma10.0PIP
42gemistocytic astrocytoma10.0S100B
43epithelial-myoepithelial carcinoma10.0KRT14
44cystadenoma10.0KRT7
45desmoid tumor10.0ACTC1
46tuberous sclerosis10.0S100B
47mixed cell type cancer10.0KRT7
48pilocytic astrocytoma10.0S100B
49histiocytosis10.0S100B
50epidermolysis bullosa10.0KRT14

Graphical network of the top 20 diseases related to Sweat Gland Carcinoma:



Diseases related to sweat gland carcinoma

Clinical Features for Sweat Gland Carcinoma

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Drugs & Therapeutics for Sweat Gland Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Sweat Gland Carcinoma

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Anatomical Context for Sweat Gland Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Sweat Gland Carcinoma:

32
Skin, Breast, Lymph node, Lung, Bone, Kidney, Salivary gland

Animal Models for Sweat Gland Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sweat Gland Carcinoma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.9TP53, ACTC1
2MP:00053799.9TP53, EGF
3MP:00107719.7TP53, KRT14, KRT1, S100B
4MP:00053768.9MUC5AC, PGR, KRT1, KRT14, ACTC1
5MP:00020068.6EGFR, MUC1, PGR, KRT14, ERBB2, TP63
6MP:00053898.6EGF, EGFR, PCNA, KRT14, ERBB2, TP53
7MP:00053817.7EGF, EGFR, MUC5AC, MUC1, KRT14, KRT8
8MP:00053857.7S100A1, EGFR, PGR, KRT8, ACTC1, ERBB2
9MP:00028737.6S100B, S100A1, EGF, EGFR, MUC1, PGR
10MP:00053877.2EGF, EGFR, MUC5AC, PCNA, PGR, KRT14
11MP:00053847.1PCNA, PGR, KRT14, KRT7, ACTC1, ERBB2

Publications for Sweat Gland Carcinoma

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50PubMed
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Articles related to Sweat Gland Carcinoma:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Mucin-producing sweat gland carcinoma of the eyelid: diagnostic and prognostic considerations. (23218693)
2013
2
Late lung metastasis of a primary eccrine sweat gland carcinoma 10 years after initial surgical treatment: the first clinical documentation. (23710393)
2013
3
Recurrent endocrine mucin-producing sweat gland carcinoma in the eyelid. (23582005)
2013
4
A case of endocrine mucin-producing sweat gland carcinoma. (22524664)
2012
5
Primary adenoid cystic carcinoma of sweat glands in vulva: report of an unusual case and review of the literature. (21651649)
2011
6
Endocrine mucin-producing sweat gland carcinoma of the eyelid. (18356733)
2008
7
Apocrine (cutaneous) sweat gland carcinoma of axilla with signet ring cells: a diagnostic dilemma on fine-needle aspiration cytology. (18773442)
2008
8
Recurrent endocrine mucin-producing sweat gland carcinoma. (18022131)
2007
9
Treatment of synchronous mucinous carcinoma and endocrine mucin-producing sweat gland carcinoma with Mohs' micrographic surgery. (15841644)
2005
10
Small cell sweat gland carcinoma of childhood. (16311358)
2005
11
Sentinel lymph node analysis in patients with sweat gland carcinoma. (12712484)
2003
12
Recurrent polymorphous sweat gland carcinoma of the skin. (12063490)
2002
13
Apocrine sweat gland carcinoma. (11339615)
2001
14
Malignant apocrine sweat gland carcinoma of the caruncle. (12045959)
2000
15
Eccrine sweat gland carcinoma: a case report and review of diagnosis and treatment. (10860232)
2000
16
Sweat gland carcinoma with multiple local recurrences: a case report. (10655575)
1999
17
Epidermal growth factor, estrogen, and progesterone receptor expression in primary sweat gland carcinomas and primary and metastatic mammary carcinomas. (10463481)
1999
18
Homologous carcinomas of the breasts, skin, and salivary glands. A histologic and immunohistochemical comparison of ductal mammary carcinoma, ductal sweat gland carcinoma, and salivary duct carcinoma. (9426521)
1998
19
Sweat gland carcinoma of the foot: a review and patient report. (9827961)
1998
20
Follow-up of sweat gland carcinoma by FDG-PET imaging. (9442968)
1998
21
Endocrine mucin-producing sweat gland carcinoma: a cutaneous neoplasm analogous to solid papillary carcinoma of breast. (9414195)
1997
22
Sweat gland carcinoma. (9149787)
1997
23
Sweat gland carcinoma. Case report and review of the literature. (9107287)
1997
24
Sweat gland carcinoma diagnosed by fine needle aspiration (FNA). (8833877)
1996
25
Sweat gland carcinoma with metastases to the skin: response to 5-fluorouracil chemotherapy. (7796614)
1995
26
Sweat gland carcinoma in a patient with sarcoidosis and primary biliary cirrhosis. (8075455)
1994
27
Giant primary mucinous sweat gland carcinoma of the scalp. (8403482)
1993
28
Sweat gland carcinoma with mucinous and infiltrating duct-like patterns. (1331212)
1992
29
Cytokeratin expression in mucinous sweat gland carcinomas: an immunohistochemical analysis of four cases. (1380481)
1992
30
Spinal metastasis of sweat gland carcinoma. A case report. (1750011)
1991
31
Metastatic eccrine sweat gland carcinoma: case report. (3243367)
1988
32
Sweat gland carcinoma with bone and visceral metastases. Prolonged complete remission lasting 16 months as a result of chemotherapy. (3594354)
1987
33
Inguinal sweat gland carcinoma with choriocarcinomatous differentiation. (2425551)
1986
34
Axillary sweat gland carcinoma versus amelanotic malignant melanoma. (4089996)
1985
35
Metastasizing eccrine sweat gland carcinoma. Report of a case. (6721544)
1984
36
Sweat gland carcinoma with hypercalcemia. (7132372)
1982
37
Sweat gland carcinoma. (287812)
1979
38
Sweat gland carcinoma with syringomatous features: a light microscopic and ultrastructural study. (455242)
1979
39
Metastatic sweat gland carcinoma. (703462)
1978
40
Sweat gland carcinoma: a clinico-pathological reappraisal. (1249938)
1976
41
Sweat gland carcinoma. Report of a case in an unusual location and review of literature. (4823258)
1974
42
Sweat gland carcinoma arising in irradiated skin. (5011405)
1972
43
Apocrine sweat gland carcinoma with lymphatic invasion in a dog. (4481120)
1972
44
Sweat gland carcinoma: a clinico-pathologic study of 83 patients. (5100098)
1971
45
Apocrine sweat gland carcinoma. Report of a case. (5476740)
1970
46
Virus-like particles observed in a human sweat gland carcinoma. (6049216)
1967
47
Sweat-gland carcinoma. A clinicopathologic problem. (4164856)
1967
48
VERY LATE RECURRENCE OF A PREVIOUSLY EXCISED SWEAT GLAND CARCINOMA: CASE REPORT WITH REVIEW OF THE LITERATURE. (14316199)
1965
49
Sweat gland carcinoma. (13327847)
1956
50
Apocrine tissue, chronic cystic mastitis and sweat gland carcinoma of the breast. (18104212)
1949

Genetic Variations for Sweat Gland Carcinoma

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Expression for genes affiliated with Sweat Gland Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sweat Gland Carcinoma

Search GEO for disease gene expression data for Sweat Gland Carcinoma.

Pathways for genes affiliated with Sweat Gland Carcinoma

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29KEGG, 37NCBI BioSystems Database, 59Tocris Bioscience, 53Reactome, 12EMD Millipore, 52R&D Systems, 51QIAGEN, 49PharmGKB, 4Cell Signaling Technology, 55SinoBiological
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Pathways related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.1TP53
2
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9.8TP53, TP63
3
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9.8ERBB2, TP53
49.5ERBB2, EGFR, EGF
5
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9.5EGF, EGFR, ERBB2
6
Transcription Androgen Receptor nuclear signaling
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9.5EGF, EGFR, ERBB2
79.5TP53, ERBB2, EGFR
8
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9.4TP53, EGFR, EGF
99.4EGF, EGFR, TP53
10
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9.3EGF, EGFR, MUC1, ERBB2
119.2TP53, TP63, ERBB2, EGFR
12
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9.1TP53, ERBB2, EGFR, EGF
13
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9.1EGF, EGFR, ERBB2, TP53
14
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9.1TP53, ERBB2, EGFR, EGF
15
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9.1TP53, ERBB2, EGF, PIP
16
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9.0ERBB2, PGR, EGFR, EGF, S100B
179.0KRT7, KRT13, KRT8, ACTC1
189.0EGFR, PCNA, TP63, TP53
198.9EGF, EGFR, MUC1, ERBB2, TP53
208.8KRT8, KRT13, KRT7, KRT14, KRT1
218.7EGF, EGFR, KRT7, KRT8
22
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8.7PIP, EGF, EGFR, ERBB2, TP53
238.6EGF, EGFR, PCNA, ERBB2, TP53
24
Hide members
8.6EGF, EGFR, PCNA, ERBB2, TP53

Compounds for genes affiliated with Sweat Gland Carcinoma

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44Novoseek, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB
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Compounds related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1adriamycin449.8MUC1, PGR, KRT8
2jnj 28871063 hydrochloride599.8EGF, EGFR, ERBB2
3ag 490599.8EGF, EGFR, ERBB2
4s 100449.8ACTC1, MUC1, S100B
5ag 1478 hydrochloride599.8EGF, EGFR, ERBB2
6pd158780449.8ERBB2, EGFR, EGF
7iressa599.8ERBB2, EGFR, EGF
8pertuzumab44 49 1111.7EGF, EGFR, ERBB2
92-methoxyethanol449.7S100A1, KRT14, ACTC1, TP63
10capecitabine44 49 1111.6ERBB2, PGR, EGFR, EGF
11lapatinib44 49 1111.6ERBB2, PGR, EGFR, EGF
12pki-166449.6EGF, EGFR, ERBB2
13taxane449.5EGFR, PGR, ERBB2, TP53
14eosin449.5S100B, MUC1, PCNA
154-hydroxytamoxifen449.4S100B, EGF, EGFR, PGR, ERBB2
16trastuzumab44 49 1111.4EGF, EGFR, MUC1, PGR, ERBB2
17dexamethasone44 49 28 1112.4PCNA, MUC5AC, S100B
18progestin449.3EGF, EGFR, MUC1, PGR, ERBB2
19geldanamycin44 49 59 1112.2EGF, EGFR, PGR, ERBB2, TP53
20leucovorin44 49 1111.1EGF, EGFR, PGR, ERBB2
21fulvestrant44 49 28 1112.1EGF, EGFR, PCNA, PGR, ERBB2
22agar449.1EGF, EGFR, MUC1, PGR, KRT8, ERBB2
23biotin44 11 2410.9S100A1, MUC1, PCNA, KRT1, ACTC1, ERBB2
24bromodeoxyuridine448.9S100B, EGF, PCNA, KRT1, KRT14, KRT8
25reticulin448.9S100B, MUC1, PCNA, KRT7, ACTC1
26paclitaxel44 49 1110.8S100B, EGF, EGFR, PGR, KRT8, ERBB2
27gemcitabine44 49 1110.8EGF, EGFR, MUC1, PCNA, ERBB2, TP53
28steroid448.6PIP, EGF, MUC5AC, KRT1, KRT8, ACTC1
29matrigel448.5EGF, MUC1, KRT7, KRT8, ACTC1, TP63
30doxorubicin44 49 1110.2EGF, EGFR, PGR, KRT20, KRT8, ERBB2
31iron44 249.1S100B, S100A1, KRT14, KRT7, KRT20, KRT8
32methotrexate44 49 1110.1MUC5AC, MUC1, PCNA, PGR, KRT7, ERBB2
33formaldehyde44 249.0S100B, MUC1, PCNA, KRT7, KRT20, ACTC1
34cisplatin44 49 59 1111.0EGF, EGFR, MUC1, PCNA, KRT14, KRT8
355fluorouracil447.9EGF, EGFR, MUC5AC, MUC1, PCNA, PGR
36retinoid447.8EGFR, MUC5AC, PGR, KRT1, KRT14, KRT7
37arginine447.7S100B, PCNA, KRT1, KRT14, KRT7, ERBB2
38cysteine447.7S100B, S100A1, EGF, MUC5AC, MUC1, PCNA
39tamoxifen44 49 28 1110.7PIP, EGF, EGFR, MUC1, PCNA, PGR
40serine447.5S100B, EGF, EGFR, MUC5AC, MUC1, KRT1
41mucicarmine447.5TP63, ACTC1, KRT20, KRT7, KRT14, MUC1
42hematoxylin447.2TP63, ACTC1, KRT8, KRT20, KRT7, KRT14
43b 723447.0PIP, S100A1, S100B, MUC1, PCNA, KRT7
44calcium44 49 11 249.9S100B, S100A1, EGF, MUC5AC, MUC1, KRT1
45vegf446.2ACTC1, KRT8, KRT20, KRT7, PGR, PCNA
46tyrosine445.9MUC1, MUC5AC, EGFR, EGF, S100A1, S100B
47testosterone44 59 11 248.4KRT8, KRT20, KRT7, KRT1, PGR, PCNA
48retinoic acid44 246.3KRT14, KRT1, PGR, PCNA, MUC1, MUC5AC
49paraffin444.4TP53, TP63, ERBB2, ACTC1, KRT8, KRT13
50progesterone44 59 28 11 248.3TP53, PIP, S100A1, S100B, EGF, EGFR

GO Terms for genes affiliated with Sweat Gland Carcinoma

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16Gene Ontology
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Cellular components related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.6TP53, TP63, MUC1
2keratin filamentGO:0450958.8KRT8, KRT13, KRT7, KRT14, KRT1
3intermediate filamentGO:0058828.6KRT14, KRT7, KRT20, KRT8
4cytoplasmGO:0057376.2S100B, EGFR, MUC1, PCNA, KRT14, KRT7

Biological processes related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of catenin import into nucleusGO:0354139.8EGFR, EGF
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.7TP53, TP63, MUC1
3mitotic G1 DNA damage checkpointGO:0315719.5TP53, TP63
4positive regulation of MAP kinase activityGO:0434069.4ERBB2, EGFR, EGF
5phosphatidylinositol-mediated signalingGO:0480159.1ERBB2, PCNA, EGFR, EGF
6cell proliferationGO:0082838.7S100B, EGFR, PCNA, ERBB2, TP53

Molecular functions related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.9ERBB2, EGFR
2receptor signaling protein tyrosine kinase activityGO:0047169.8ERBB2, EGFR
3p53 bindingGO:0020399.6MUC1, TP63, TP53
4S100 protein bindingGO:0445489.5S100A1, S100B
5structural molecule activityGO:0051988.9KRT8, KRT13, KRT7, KRT1
6identical protein bindingGO:0428028.1TP53, S100B, S100A1, EGFR, PCNA, ERBB2
7protein bindingGO:0055155.3PCNA, MUC1, EGFR, EGF, S100A1, S100B

Products for genes affiliated with Sweat Gland Carcinoma

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Sources for Sweat Gland Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet