MCID: SWT001
MIFTS: 56

Sweat Gland Carcinoma malady

Endocrine diseases, Cancer diseases categories

Summaries for Sweat Gland Carcinoma

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32MalaCards
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MalaCards: Sweat Gland Carcinoma, also known as malignant tumor of the sweat gland, is related to syringocystadenoma papilliferum and eccrine porocarcinoma. An important gene associated with Sweat Gland Carcinoma is KRT1 (keratin 1), and among its related pathways are Glioma and Apoptosis Modulation and Signaling. The compounds adriamycin and ag 1478 hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and lymph node, and related mouse phenotypes are muscle and endocrine/exocrine gland.

Aliases & Classifications for Sweat Gland Carcinoma

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

sweat gland carcinoma 8
malignant tumor of the sweat gland 8
malignant neoplasm of sweat gland 8
carcinoma of the sweat gland 8
sweat gland adenocarcinoma 60
tumor of the sweat gland 8
neoplasm of sweat gland 8
sweat gland tumor nos 8
sweat gland neoplasm 8
sweat gland cancer 8
sweat gland tumor 8


Related Diseases for Sweat Gland Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Sweat Gland Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 240)
idRelated DiseaseScoreTop Affiliating Genes
1syringocystadenoma papilliferum30.1PIP
2eccrine porocarcinoma30.1MUC1
3smooth muscle tumor30.1ACTC1, PGR, PCNA, S100A1, S100B
4hidradenoma30.1MUC1, PIP
5mammary paget's disease30.1ERBB2, KRT20, KRT7, PGR, MUC1
6myoepithelioma30.1TP63, ACTC1, KRT14, S100A1, S100B
7melanoma30.1TP53, TP63, ACTC1, KRT8, KRT14, PCNA
8papillary carcinoma30.1TP63, ERBB2, ACTC1, KRT20, KRT7, KRT14
9mucoepidermoid carcinoma30.1TP63, ACTC1, KRT13, KRT7, KRT14, PCNA
10adenoid cystic carcinoma30.1TP63, ERBB2, ACTC1, KRT8, KRT20, KRT7
11adenocarcinoma30.0TP53, TP63, ERBB2, ACTC1, KRT8, KRT13
12sweat gland disease10.4
13apocrine sweat gland neoplasm10.4
14breast apocrine carcinoma10.4
15small cell carcinoma10.3
16malignant acrospiroma10.3
17spiradenoma10.3
18eccrine sweat gland cancer10.3
19hidradenocarcinoma10.1
20eccrine papillary adenoma10.1
21apocrine adenoma10.1
22bone carcinoma10.1
23amelanotic melanoma10.1
24penis paget's disease10.1
25primary biliary cirrhosis10.1
26malignant spiradenoma10.1
27breast papillary carcinoma10.1
28hypercalcemia10.1
29adenoiditis10.1
30breast mucinous carcinoma10.1
31mastitis10.1
32sarcoidosis10.1
33skin disease10.1
34vulva adenocarcinoma10.1
35vulvar disease10.1
36eccrine acrospiroma10.1
37nodular hidradenoma10.1
38dermal eccrine cylindroma10.1
39keratosis10.0KRT1
40hemangioma10.0ACTC1
41hidrocystoma10.0PIP
42gemistocytic astrocytoma10.0S100B
43epithelial-myoepithelial carcinoma10.0KRT14
44cystadenoma10.0KRT7
45desmoid tumor10.0ACTC1
46tuberous sclerosis10.0S100B
47mixed cell type cancer10.0KRT7
48pilocytic astrocytoma10.0S100B
49histiocytosis10.0S100B
50epidermolysis bullosa10.0KRT14

Graphical network of the top 20 diseases related to Sweat Gland Carcinoma:



Diseases related to sweat gland carcinoma

Clinical Features for Sweat Gland Carcinoma

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Drugs & Therapeutics for Sweat Gland Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Sweat Gland Carcinoma

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Anatomical Context for Sweat Gland Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Sweat Gland Carcinoma:

32
Skin, Breast, Lymph node, Lung, Bone, Kidney, Salivary gland

Animal Models for Sweat Gland Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sweat Gland Carcinoma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.9TP53, ACTC1
2MP:00053799.9TP53, EGF
3MP:00107719.7TP53, KRT14, KRT1, S100B
4MP:00053768.9MUC5AC, PGR, KRT1, KRT14, ACTC1
5MP:00020068.6EGFR, MUC1, PGR, KRT14, ERBB2, TP63
6MP:00053898.6EGF, EGFR, PCNA, KRT14, ERBB2, TP53
7MP:00053817.7EGF, EGFR, MUC5AC, MUC1, KRT14, KRT8
8MP:00053857.7S100A1, EGFR, PGR, KRT8, ACTC1, ERBB2
9MP:00028737.6S100B, S100A1, EGF, EGFR, MUC1, PGR
10MP:00053877.2EGF, EGFR, MUC5AC, PCNA, PGR, KRT14
11MP:00053847.1PCNA, PGR, KRT14, KRT7, ACTC1, ERBB2

Publications for Sweat Gland Carcinoma

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50PubMed
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Articles related to Sweat Gland Carcinoma:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Aggressiveness of poorly differentiated sweat gland carcinoma in kidney transplant recipient. (23829827)
2013
2
Apocrine sweat gland carcinoma: initial evaluation, staging, and response monitoring using 18F-FDG PET/CT. (23377411)
2013
3
Endocrine mucin-producing sweat gland carcinoma: report of two cases of an under-recognized malignant neoplasm and review of the literature. (22892473)
2013
4
Endocrine mucin producing sweat gland carcinoma: a clinicopathological analysis of three cases. (22935981)
2012
5
A case of histiocytoid variant eccrine sweat gland carcinoma of the orbit. (21350696)
2011
6
Sweat gland carcinoma. (19116525)
2009
7
Endocrine mucin-producing sweat gland carcinoma: report of a case and review of the literature. (17177942)
2006
8
Sweat gland carcinoma with lung metastases. (17998708)
2006
9
Histiocytoid eccrine sweat gland carcinoma of the eyelid: report of a case. (16869823)
2006
10
Endocrine mucin-producing sweat gland carcinoma: twelve new cases suggest that it is a precursor of some invasive mucinous carcinomas. (16160476)
2005
11
Sweat gland carcinoma. (14964551)
2004
12
Lymphatic mapping and sentinel lymph node biopsy in the detection of early metastasis from sweat gland carcinoma. (12712485)
2003
13
Histiocytoid variant of eccrine sweat gland carcinoma of the eyelid and orbit: report of five cases. (11874761)
2002
14
Facial sweat gland carcinoma metastasizing to neck nodes: a diagnostic and therapeutic challenge. (11735822)
2001
15
Metastatic sweat gland carcinoma. (11762625)
2001
16
Cytologic features of pleural effusion in apocrine sweat gland carcinoma. A case report. (11213508)
2001
17
Sweat gland carcinoma with multiple local recurrences: a case report. (10655575)
1999
18
Epidermal growth factor, estrogen, and progesterone receptor expression in primary sweat gland carcinomas and primary and metastatic mammary carcinomas. (10463481)
1999
19
Small cell sweat gland carcinoma in childhood. (9500223)
1998
20
Sweat gland carcinoma in a human immunodeficiency virus-infected patient. (7539911)
1995
21
Sweat gland carcinoma of the vulva. (7618462)
1995
22
A case of ductal sweat gland carcinoma connected to syringocystadenoma papilliferum arising in nevus sebaceus. (7699123)
1994
23
Adenoid cystic sweat gland carcinoma. A clinicopathologic and immunohistochemical study]. (8050902)
1994
24
Vulvar Paget's disease and sweat gland carcinoma--report of a case and review of the literature. (7954012)
1994
25
Adenocarcinoma of the mammary-like glands of the vulva: a concept unifying sweat gland carcinoma of the vulva, carcinoma of supernumerary mammary glands and extramammary Paget's disease. (8040464)
1994
26
Surgical resection for pulmonary metastases of sweat gland carcinoma. (8128411)
1994
27
Sweat gland carcinoma: an easily confused skin malignancy. (8334563)
1993
28
Mucoepidermoid carcinoma metastatic to the skin. An histologic mimic of a primary sweat gland carcinoma. (1607459)
1992
29
Sweat gland carcinoma metastatic to the tibia. A case report. (3420043)
1988
30
Sweat gland carcinoma ex eccrine spiradenoma. (2847574)
1987
31
Mucinous (adenocystic) sweat gland carcinoma of the great toe. (2833541)
1987
32
Treatment of metastatic sweat gland carcinoma by a four drug combination chemotherapy: response in two cases. (2422504)
1986
33
Enlarging ulcerated tumor on the back. Eccrine sweat gland carcinoma (SGC)--metastatic. (3707177)
1986
34
Chemotherapy of metastatic sweat gland carcinoma. A retrospective review. (3909802)
1985
35
Extramammary Paget's disease. Arising in knee region in association with sweat gland carcinoma. (6205637)
1984
36
Sweat gland carcinoma of the hand: two cases of malignant eccrine spiradenoma. (6096437)
1984
37
Sweat gland carcinoma with hypercalcemia. (7132372)
1982
38
Paget's disease of the penis and adjacent skin: its association with fatal sweat gland carcinoma. (6269515)
1981
39
Eccrine sweat gland carcinoma of the eyelid with orbital involvement. (7447777)
1980
40
Adenosquamous carcinoma of skin appendages (adenoid squamous cell carcinoma, pseudoglandular squamous cell carcinoma, adenocanthoma of sweat gland of Lever) of the vulva: a clinical and ultrastructural study. (709534)
1978
41
Sweat gland carcinoma. Current concepts of surgical management. (942300)
1976
42
Sweat gland carcinoma with regional lymph node metastasis. (1155958)
1975
43
Eccrine sweat gland carcinoma with metastases. (5060426)
1972
44
Sweat gland carcinoma. (5560851)
1971
45
Intracranial metastasis of sweat gland carcinoma. Case report. (4288759)
1966
46
APOCRINE GLAND CARCINOMA (SWEAT GLAND CARCINOMA) OF THE BREAST. (14119212)
1964
47
Sweat-gland carcinoma of eyelid. (14430109)
1959
48
Sweat-gland carcinoma. (13261057)
1955
49
Metastasizing sweat gland carcinoma of the scalp involving transverse sinus. (13207521)
1954
50
Sweat-gland carcinoma with proved metastases; report of a case. (13141231)
1954

Genetic Variations for Sweat Gland Carcinoma

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Expression for genes affiliated with Sweat Gland Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sweat Gland Carcinoma

Search GEO for disease gene expression data for Sweat Gland Carcinoma.

Pathways for genes affiliated with Sweat Gland Carcinoma

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29KEGG, 37NCBI BioSystems Database, 59Tocris Bioscience, 53Reactome, 12EMD Millipore, 52R&D Systems, 51QIAGEN, 49PharmGKB, 4Cell Signaling Technology, 55SinoBiological
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Pathways related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.1TP53
2
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9.8TP53, TP63
3
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9.8ERBB2, TP53
49.5ERBB2, EGFR, EGF
5
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9.5EGF, EGFR, ERBB2
6
Transcription Androgen Receptor nuclear signaling
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9.5EGF, EGFR, ERBB2
79.5TP53, ERBB2, EGFR
8
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9.4TP53, EGFR, EGF
99.4EGF, EGFR, TP53
10
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9.3EGF, EGFR, MUC1, ERBB2
119.2TP53, TP63, ERBB2, EGFR
12
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9.1TP53, ERBB2, EGFR, EGF
13
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9.1EGF, EGFR, ERBB2, TP53
14
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9.1TP53, ERBB2, EGFR, EGF
15
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9.1TP53, ERBB2, EGF, PIP
16
Hide members
9.0ERBB2, PGR, EGFR, EGF, S100B
179.0KRT7, KRT13, KRT8, ACTC1
189.0EGFR, PCNA, TP63, TP53
198.9EGF, EGFR, MUC1, ERBB2, TP53
208.8KRT8, KRT13, KRT7, KRT14, KRT1
218.7EGF, EGFR, KRT7, KRT8
22
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8.7PIP, EGF, EGFR, ERBB2, TP53
238.6EGF, EGFR, PCNA, ERBB2, TP53
24
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8.6EGF, EGFR, PCNA, ERBB2, TP53

Compounds for genes affiliated with Sweat Gland Carcinoma

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44Novoseek, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB
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Compounds related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1adriamycin449.8KRT8, PGR, MUC1
2ag 1478 hydrochloride599.8EGF, EGFR, ERBB2
3pd158780449.8EGFR, ERBB2, EGF
4s 100449.8S100B, ACTC1, MUC1
5iressa599.8EGFR, ERBB2, EGF
6ag 490599.8EGFR, EGF, ERBB2
7jnj 28871063 hydrochloride599.8EGF, ERBB2, EGFR
8pertuzumab44 49 1111.7EGF, ERBB2, EGFR
92-methoxyethanol449.7ACTC1, KRT14, S100A1, TP63
10capecitabine44 49 1111.6PGR, ERBB2, EGFR, EGF
11lapatinib44 49 1111.6EGF, PGR, ERBB2, EGFR
12pki-166449.6ERBB2, EGFR, EGF
13taxane449.5EGFR, TP53, ERBB2, PGR
14eosin449.5S100B, MUC1, PCNA
154-hydroxytamoxifen449.4S100B, EGF, EGFR, PGR, ERBB2
16trastuzumab44 49 1111.4EGF, EGFR, MUC1, ERBB2, PGR
17dexamethasone44 49 28 1112.4S100B, PCNA, MUC5AC
18progestin449.3PGR, MUC1, EGFR, EGF, ERBB2
19geldanamycin44 49 59 1112.2ERBB2, EGFR, EGF, PGR, TP53
20leucovorin44 49 1111.1PGR, EGFR, EGF, ERBB2
21fulvestrant44 49 28 1112.1EGF, EGFR, ERBB2, PGR, PCNA
22agar449.1ERBB2, KRT8, EGFR, PGR, MUC1, EGF
23biotin44 11 2410.9S100A1, MUC1, KRT1, ACTC1, ERBB2, PCNA
24bromodeoxyuridine448.9KRT1, KRT14, KRT8, TP63, EGF, PCNA
25reticulin448.9PCNA, S100B, MUC1, KRT7, ACTC1
26paclitaxel44 49 1110.8ERBB2, KRT8, PGR, TP53, S100B, EGF
27gemcitabine44 49 1110.8EGFR, EGF, MUC1, PCNA, ERBB2, TP53
28steroid448.6ERBB2, ACTC1, KRT8, KRT1, MUC5AC, EGF
29matrigel448.5TP63, ACTC1, KRT8, KRT7, MUC1, EGF
30doxorubicin44 49 1110.2ERBB2, TP53, EGF, EGFR, PGR, KRT20
31iron44 249.1KRT8, S100B, S100A1, ACTC1, KRT14, KRT20
32methotrexate44 49 1110.1PCNA, ERBB2, KRT7, PGR, MUC5AC, MUC1
33formaldehyde44 249.0ACTC1, KRT20, KRT7, PCNA, MUC1, S100B
34cisplatin44 49 59 1111.0EGF, TP63, TP53, EGFR, MUC1, PCNA
355fluorouracil447.9TP53, ERBB2, PGR, PCNA, MUC1, EGF
36retinoid447.8TP53, KRT7, KRT8, EGFR, KRT1, KRT14
37arginine447.7TP63, KRT14, KRT1, PCNA, S100B, ERBB2
38cysteine447.7S100A1, KRT8, KRT14, PGR, PCNA, MUC1
39tamoxifen44 49 28 1110.7PIP, MUC1, PCNA, KRT14, KRT8, PGR
40serine447.5KRT8, S100B, EGF, EGFR, MUC5AC, KRT14
41mucicarmine447.5KRT14, KRT7, KRT20, ACTC1, TP63, MUC1
42hematoxylin447.2S100B, S100A1, PCNA, KRT1, KRT14, KRT7
43b 723447.0PIP, MUC1, PCNA, KRT7, KRT20, KRT8
44calcium44 49 11 249.9TP63, ACTC1, KRT8, S100A1, EGF, KRT13
45vegf446.2TP53, PGR, TP63, ERBB2, S100B, EGF
46tyrosine445.9S100A1, ACTC1, S100B, EGF, EGFR, MUC5AC
47testosterone44 59 11 248.4TP63, ERBB2, ACTC1, KRT8, KRT20, KRT7
48retinoic acid44 246.3S100B, S100A1, EGF, EGFR, MUC5AC, MUC1
49paraffin444.4KRT14, PCNA, MUC1, MUC5AC, EGFR, PIP
50progesterone44 59 28 11 248.3MUC5AC, EGFR, EGF, PIP, S100A1, S100B

GO Terms for genes affiliated with Sweat Gland Carcinoma

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16Gene Ontology
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Cellular components related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.6TP53, TP63, MUC1
2keratin filamentGO:0450958.8KRT8, KRT13, KRT7, KRT14, KRT1
3intermediate filamentGO:0058828.6KRT14, KRT7, KRT20, KRT8
4cytoplasmGO:0057376.2S100B, EGFR, MUC1, PCNA, KRT14, KRT7

Biological processes related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of catenin import into nucleusGO:0354139.8EGFR, EGF
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.7TP53, TP63, MUC1
3mitotic G1 DNA damage checkpointGO:0315719.5TP53, TP63
4positive regulation of MAP kinase activityGO:0434069.4ERBB2, EGFR, EGF
5phosphatidylinositol-mediated signalingGO:0480159.1ERBB2, PCNA, EGFR, EGF
6cell proliferationGO:0082838.7S100B, EGFR, PCNA, ERBB2, TP53

Molecular functions related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.9ERBB2, EGFR
2receptor signaling protein tyrosine kinase activityGO:0047169.8ERBB2, EGFR
3p53 bindingGO:0020399.6MUC1, TP63, TP53
4S100 protein bindingGO:0445489.5S100A1, S100B
5structural molecule activityGO:0051988.9KRT8, KRT13, KRT7, KRT1
6identical protein bindingGO:0428028.1TP53, S100B, S100A1, EGFR, PCNA, ERBB2
7protein bindingGO:0055155.3PCNA, MUC1, EGFR, EGF, S100A1, S100B

Products for genes affiliated with Sweat Gland Carcinoma

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Sources for Sweat Gland Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet