MCID: SWT001
MIFTS: 59

Sweat Gland Carcinoma malady

Cancer diseases, Endocrine diseases categories
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Summaries for Sweat Gland Carcinoma

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MalaCards based summary: Sweat Gland Carcinoma, also known as malignant tumor of the sweat gland, is related to syringocystadenoma papilliferum and eccrine porocarcinoma. An important gene associated with Sweat Gland Carcinoma is S100B (S100 calcium binding protein B), and among its related pathways are TP53 network and EGFR Transactivation by Gastrin. The compounds jnj 28871063 hydrochloride and ag 490 have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and lymph node, and related mouse phenotypes are pigmentation and limbs/digits/tail.

Aliases & Classifications for Sweat Gland Carcinoma

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Sweat Gland Carcinoma, Aliases & Descriptions:

Name: Sweat Gland Carcinoma 8
Malignant Tumor of the Sweat Gland 8 62
Malignant Neoplasm of Sweat Gland 8 62
Carcinoma of the Sweat Gland 8 62
Tumor of the Sweat Gland 8 62
Neoplasm of Sweat Gland 8 62
 
Sweat Gland Cancer 8 62
Sweat Gland Adenocarcinoma 62
Sweat Gland Neoplasms 62
Sweat Gland Tumor Nos 8
Sweat Gland Neoplasm 8
Sweat Gland Tumor 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Related Diseases for Sweat Gland Carcinoma

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Diseases related to Sweat Gland Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 190)
idRelated DiseaseScoreTop Affiliating Genes
1syringocystadenoma papilliferum31.2PIP
2eccrine porocarcinoma31.1MUC1
3hidradenoma31.0MUC1, PIP
4myoepithelioma30.4KRT14, S100B, S100A1, ACTC1, TP63
5breast cancer29.6EGF, EGFR, KRT14, ERBB2, PGR, PIP
6melanoma29.5KRT14, S100B, S100A1, PCNA, ACTC1, TP53
7papillary carcinoma29.4KRT20, KRT7, KRT14, ERBB2, S100A1, ACTC1
8mucoepidermoid carcinoma29.2EGFR, KRT13, KRT7, KRT14, S100A1, PCNA
9adenocarcinoma27.3EGF, EGFR, KRT13, KRT20, KRT7, KRT1
10gemistocytic astrocytoma10.6S100B
11hidrocystoma10.6PIP
12epithelial-myoepithelial carcinoma10.5KRT14
13inverted papilloma10.5KRT20
14rosai-dorfman disease10.5S100B
15metanephric adenoma10.5KRT7
16paraganglioma10.5S100A1, ACTC1
17langerhans-cell histiocytosis10.5S100B, S100A1
18supernumerary nipples10.5KRT20, PIP
19nephrogenic adenoma10.5KRT7, S100A1
20cystadenocarcinoma10.5MUC5AC, MUC1
21giant cell glioblastoma10.5EGFR
22fibrous meningioma10.5S100B, MUC1
23anaplastic ependymoma10.4S100B, MUC1
24cystadenoma10.4KRT7
25choroid plexus papilloma10.4S100B, MUC1
26granular cell tumor10.4S100B, S100A1
27secretory meningioma10.4KRT7, MUC1
28bladder adenocarcinoma10.4KRT20, KRT7
29breast fibroadenoma10.4PGR
30fibrous histiocytoma10.4S100B, ACTC1
31ovarian brenner tumor10.4KRT20, KRT7
32papilloma10.4KRT14, MUC5AC
33leiomyomatosis10.4PGR
34histiocytosis10.4S100B
35cutaneous fibrous histiocytoma10.4S100B, S100A1, ACTC1
36oxyphilic adenoma10.4KRT7, S100A1
37perineurioma10.4S100B, MUC1
38folliculitis10.4EGFR
39rhabdoid tumor10.4ACTC1, MUC1
40ganglioglioma10.4S100B
41keratoderma10.4KRT1, KRT14
42signet ring cell adenocarcinoma10.4KRT20, KRT7, PIP
43renal oncocytoma10.4KRT7, S100A1
44merkel cell carcinoma10.4KRT20, MUC1
45pseudomyxoma peritonei10.4KRT20, KRT7, MUC5AC
46fibroma10.4KRT1, S100A1, ACTC1
47giant cell tumor10.4S100B, ACTC1, MUC1
48chondrosarcoma10.3S100B, S100A1, MUC1
49pancreatic ductal carcinoma10.3KRT20, KRT7, MUC5AC
50mucinous cystadenocarcinoma10.3KRT20, KRT7, MUC1

Graphical network of the top 20 diseases related to Sweat Gland Carcinoma:



Diseases related to sweat gland carcinoma

Symptoms for Sweat Gland Carcinoma

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Drugs & Therapeutics for Sweat Gland Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Sweat Gland Carcinoma

Search NIH Clinical Center for Sweat Gland Carcinoma

Genetic Tests for Sweat Gland Carcinoma

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Anatomical Context for Sweat Gland Carcinoma

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MalaCards organs/tissues related to Sweat Gland Carcinoma:

32
Breast, Skin, Lymph node, Lung, Bone, Kidney, Salivary gland

Animal Models for Sweat Gland Carcinoma or affiliated genes

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Publications for Sweat Gland Carcinoma

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Articles related to Sweat Gland Carcinoma:

(show top 50)    (show all 122)
idTitleAuthorsYear
1
Primary Cutaneous Endocrine Mucin-Producing Sweat Gland Carcinoma Co-occurring Simultaneously With Low-Grade Ductal Mucinous Breast Cancer: A Clinicopathologic Conundrum. (25014107)
2014
2
Primary cutaneous sweat gland carcinoma. (25022402)
2014
3
Aggressiveness of poorly differentiated sweat gland carcinoma in kidney transplant recipient. (23829827)
2013
4
Mucin-producing sweat gland carcinoma of the eyelid: diagnostic and prognostic considerations. (23218693)
2013
5
Apocrine sweat gland carcinoma: initial evaluation, staging, and response monitoring using 18F-FDG PET/CT. (23377411)
2013
6
Endocrine mucin producing sweat gland carcinoma: a clinicopathological analysis of three cases. (22935981)
2012
7
Clinicopathologic characteristics of 12 patients with vulvar sweat gland carcinoma. (20606537)
2010
8
Sweat gland carcinoma - a case report. (21661469)
2010
9
Sweat gland carcinoma. (19116525)
2009
10
Endocrine mucin-producing sweat gland carcinoma: report of a case and review of the literature. (17177942)
2006
11
Sweat gland carcinoma with lung metastases. (17998708)
2006
12
Endocrine mucin-producing sweat gland carcinoma: twelve new cases suggest that it is a precursor of some invasive mucinous carcinomas. (16160476)
2005
13
Treatment of synchronous mucinous carcinoma and endocrine mucin-producing sweat gland carcinoma with Mohs' micrographic surgery. (15841644)
2005
14
Sweat gland carcinoma. (14964551)
2004
15
Recurrent polymorphous sweat gland carcinoma of the skin. (12063490)
2002
16
Histiocytoid variant of eccrine sweat gland carcinoma of the eyelid and orbit: report of five cases. (11874761)
2002
17
Facial sweat gland carcinoma metastasizing to neck nodes: a diagnostic and therapeutic challenge. (11735822)
2001
18
Metastatic sweat gland carcinoma. (11762625)
2001
19
Apocrine sweat gland carcinoma. (11339615)
2001
20
Malignant apocrine sweat gland carcinoma of the caruncle. (12045959)
2000
21
Sweat gland carcinoma with multiple local recurrences: a case report. (10655575)
1999
22
Epidermal growth factor, estrogen, and progesterone receptor expression in primary sweat gland carcinomas and primary and metastatic mammary carcinomas. (10463481)
1999
23
Sweat gland carcinoma: a clinicopathologic analysis of an expanded series in a single institution. (9727435)
1998
24
Endocrine mucin-producing sweat gland carcinoma: a cutaneous neoplasm analogous to solid papillary carcinoma of breast. (9414195)
1997
25
Sweat gland carcinoma. (9149787)
1997
26
Sweat gland carcinoma in a human immunodeficiency virus-infected patient. (7539911)
1995
27
Prognostic value of immunohistochemical staining for proliferating cell nuclear antigen, p53, and c-erbB-2 in sebaceous gland carcinoma and sweat gland carcinoma: comparison with histopathological parameter. (7909154)
1994
28
A case of ductal sweat gland carcinoma connected to syringocystadenoma papilliferum arising in nevus sebaceus. (7699123)
1994
29
Giant primary mucinous sweat gland carcinoma of the scalp. (8403482)
1993
30
Sweat gland carcinoma with mucinous and infiltrating duct-like patterns. (1331212)
1992
31
Sweat gland carcinoma ex eccrine spiradenoma. (2847574)
1987
32
Mucinous (adenocystic) sweat gland carcinoma of the great toe. (2833541)
1987
33
Inguinal sweat gland carcinoma with choriocarcinomatous differentiation. (2425551)
1986
34
Axillary sweat gland carcinoma versus amelanotic malignant melanoma. (4089996)
1985
35
Chemotherapy of metastatic sweat gland carcinoma. A retrospective review. (3909802)
1985
36
Extramammary Paget's disease. Arising in knee region in association with sweat gland carcinoma. (6205637)
1984
37
Metastasizing eccrine sweat gland carcinoma. Report of a case. (6721544)
1984
38
Sweat gland carcinoma with hypercalcemia. (7132372)
1982
39
Primary mucinous sweat gland carcinoma of the eyelid simulating metastatic carcinoma. (219696)
1979
40
Sustained complete remission of metastatic sweat gland carcinoma following regional hyperthermic perfusion. (660813)
1978
41
Metastatic sweat gland carcinoma. (703462)
1978
42
Sweat gland carcinoma: a clinico-pathological reappraisal. (1249938)
1976
43
Sweat gland carcinoma. Report of a case in an unusual location and review of literature. (4823258)
1974
44
Sweat gland carcinoma of the hand. (4825405)
1974
45
Sweat gland carcinoma arising in irradiated skin. (5011405)
1972
46
Sweat gland carcinoma: a clinico-pathologic study of 83 patients. (5100098)
1971
47
Apocrine sweat gland carcinoma. Report of a case. (5476740)
1970
48
APOCRINE GLAND CARCINOMA (SWEAT GLAND CARCINOMA) OF THE BREAST. (14119212)
1964
49
Metastasizing sweat-gland carcinoma; notes on the surgical therapy. (13636656)
1959
50
Sweat-gland carcinoma of eyelid. (14430109)
1959

Variations for Sweat Gland Carcinoma

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Expression for genes affiliated with Sweat Gland Carcinoma

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Expression patterns in normal tissues for genes affiliated with Sweat Gland Carcinoma

Search GEO for disease gene expression data for Sweat Gland Carcinoma.

Pathways for genes affiliated with Sweat Gland Carcinoma

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Pathways related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9TP63, TP53
2
Show member pathways
EGFR-dependent Endothelin signaling events37
9.8EGF, EGFR
39.5ERBB2, EGFR, EGF
4
Show member pathways
9.5ERBB2, EGFR, EGF
59.5ERBB2, EGFR, EGF
6
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.5EGF, EGFR, ERBB2
7
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.5EGF, EGFR, ERBB2
89.5EGF, EGFR, ERBB2
99.5TP53, ERBB2, EGFR
10
Show member pathways
9.5TP53, ERBB2, EGFR
11
Show member pathways
9.5EGFR, ERBB2, TP53
12
Show member pathways
Delta-Notch Signaling Pathway37
Notch Signaling Pathway37
9.4TP53, EGFR, EGF
13
Show member pathways
9.4TP53, EGFR, EGF
149.4EGF, EGFR, TP53
159.4EGF, EGFR, TP53
169.4EGFR, EGF, TP53
17
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.3EGF, EGFR, ERBB2, MUC1
189.2TP63, TP53, ERBB2, EGFR
19
Show member pathways
9.2TP53, ERBB2, EGFR, EGF
20
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.2TP53, ERBB2, EGFR, EGF
219.2TP53, ERBB2, EGFR, EGF
22
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.2TP53, ERBB2, EGFR, EGF
23
Show member pathways
9.2EGF, EGFR, ERBB2, TP53
24
Show member pathways
Signaling Pathways in Glioblastoma37
9.2EGF, EGFR, ERBB2, TP53
25
Show member pathways
9.0PGR, S100B, ERBB2, EGFR, EGF
269.0EGFR, PCNA, TP53, TP63
278.9EGF, EGFR, ERBB2, MUC1, TP53
288.9KRT13, KRT7, KRT1, KRT14
29
Show member pathways
8.7PIP, TP53, ERBB2, EGFR, EGF
30
Show member pathways
8.7EGF, EGFR, ERBB2, TP53, PIP
31
Show member pathways
Signal transduction PTEN pathway60
8.6TP53, PCNA, ERBB2, EGFR, EGF
328.6TP53, PCNA, ERBB2, EGFR, EGF
33
Show member pathways
8.5EGF, EGFR, ERBB2, MUC1, TP53, PIP

Compounds for genes affiliated with Sweat Gland Carcinoma

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Compounds related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 143)
idCompoundScoreTop Affiliating Genes
1jnj 28871063 hydrochloride619.8ERBB2, EGFR, EGF
2ag 490619.8ERBB2, EGFR, EGF
3ag 1478 hydrochloride619.8ERBB2, EGFR, EGF
4pd158780449.8EGF, EGFR, ERBB2
5iressa619.8EGF, EGFR, ERBB2
6pertuzumab44 50 1111.7EGF, EGFR, ERBB2
7eosin449.7MUC1, PCNA, S100B
82-methoxyethanol449.7TP63, ACTC1, S100A1, KRT14
9pki-166449.6ERBB2, EGFR, EGF
10capecitabine44 50 1111.6PGR, ERBB2, EGFR, EGF
11lapatinib44 50 1111.5PGR, ERBB2, EGFR, EGF
12s 100449.5S100B, ACTC1, MUC1
13taxane449.5TP53, PGR, ERBB2, EGFR
144-hydroxytamoxifen449.4PGR, S100B, ERBB2, EGFR, EGF
15trastuzumab44 50 1111.3PGR, MUC1, ERBB2, EGFR, EGF
16progestin449.3PGR, MUC1, ERBB2, EGFR, EGF
17leucovorin44 50 1111.2PGR, ERBB2, EGFR, EGF
18geldanamycin44 50 61 1112.2EGF, EGFR, ERBB2, PGR, TP53
19fulvestrant44 50 28 1112.1PGR, PCNA, ERBB2, EGFR, EGF
20bromodeoxyuridine449.1TP63, PCNA, S100B, KRT14, KRT1, EGF
21biotin44 24 1111.0MUC1, ACTC1, PCNA, S100A1, ERBB2, KRT1
22reticulin448.9MUC1, ACTC1, PCNA, S100B, KRT7
23egcg448.9TP53, PCNA, ERBB2, EGFR, EGF
24gemcitabine44 50 1110.8TP53, MUC1, PCNA, ERBB2, EGFR, EGF
25proline448.6TP53, MUC5AC, S100B, KRT14, KRT1, KRT13
26paclitaxel44 50 1110.5TP53, PGR, PCNA, S100B, ERBB2, EGFR
27doxorubicin44 50 1110.3TP63, TP53, PGR, ERBB2, KRT20, EGFR
28cisplatin44 50 61 1111.3TP63, TP53, MUC1, PCNA, ERBB2, KRT14
29dexamethasone44 50 28 1111.2PGR, MUC1, MUC5AC, ACTC1, PCNA, S100B
30methotrexate50 44 1110.1PGR, MUC1, MUC5AC, PCNA, ERBB2, KRT7
31steroid448.1PIP, TP63, PGR, MUC5AC, ACTC1, S100B
32retinoid448.0TP53, PGR, MUC5AC, KRT14, KRT1, KRT7
335fluorouracil448.0TP53, PGR, MUC1, MUC5AC, PCNA, ERBB2
34formaldehyde44 249.0MUC1, ACTC1, PCNA, S100B, ERBB2, KRT7
35iron44 248.9S100A1, S100B, KRT14, KRT7, KRT20, ACTC1
36arginine447.9TP63, TP53, PCNA, S100B, ERBB2, KRT14
37cysteine447.9PGR, MUC1, MUC5AC, PCNA, S100A1, S100B
38tamoxifen44 50 28 1110.9PIP, TP53, PGR, MUC1, PCNA, ERBB2
39serine447.8TP53, MUC1, MUC5AC, S100B, ERBB2, KRT14
40calcium44 50 24 1110.6TP63, MUC1, MUC5AC, ACTC1, S100A1, S100B
41mucicarmine447.5KRT20, KRT7, KRT14, S100B, S100A1, ACTC1
42b 723447.2PCNA, ACTC1, MUC1, TP63, PIP, S100A1
43hematoxylin446.6KRT20, KRT7, KRT1, KRT14, S100B, S100A1
44vegf446.4EGF, EGFR, KRT20, KRT7, ERBB2, S100B
45tyrosine446.1S100A1, ACTC1, MUC5AC, MUC1, TP63, S100B
46retinoic acid44 246.6MUC5AC, MUC1, PGR, TP53, TP63, ACTC1
47testosterone44 61 24 118.6PGR, TP63, PIP, MUC1, MUC5AC, EGF
48paraffin444.6EGFR, KRT13, KRT20, KRT7, KRT1, KRT14
49estrogen444.5EGF, PIP, TP63, TP53, EGFR, KRT20
50progesterone44 28 61 24 118.5MUC1, PGR, TP53, TP63, PIP, MUC5AC

GO Terms for genes affiliated with Sweat Gland Carcinoma

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Cellular components related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.3MUC1, TP53, TP63
2apical plasma membraneGO:0163249.2PIP, MUC1, ERBB2, EGFR
3keratin filamentGO:0450959.0KRT14, KRT1, KRT7, KRT13
4intermediate filamentGO:0058828.8KRT20, KRT7, KRT14
5extracellular spaceGO:0056158.6PIP, ACTC1, S100B, KRT1, EGFR, EGF
6extracellular vesicular exosomeGO:0700627.7EGF, PIP, MUC1, MUC5AC, ACTC1, PCNA
7cytoplasmGO:0057376.4TP63, TP53, MUC1, ACTC1, PCNA, S100B

Biological processes related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:03157110.0TP53, TP63
2regulation of angiogenesisGO:04576510.0KRT1, ERBB2
3response to X-rayGO:0101659.9TP53, TP63
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.9MUC1, TP53, TP63
5positive regulation of catenin import into nucleusGO:0354139.9EGF, EGFR
6positive regulation of MAP kinase activityGO:0434069.7EGF, EGFR, ERBB2
7positive regulation of phosphorylationGO:0423279.7EGF, EGFR
8peptidyl-tyrosine phosphorylationGO:0181089.7ERBB2, EGFR, EGF
9negative regulation of apoptotic processGO:0430669.3TP63, TP53, ACTC1, EGFR
10fibroblast growth factor receptor signaling pathwayGO:0085439.2EGF, EGFR, ERBB2
11phosphatidylinositol-mediated signalingGO:0480159.2PCNA, ERBB2, EGFR, EGF
12cell proliferationGO:0082839.0TP53, PCNA, S100B, ERBB2, EGFR

Molecular functions related to Sweat Gland Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.9EGFR, ERBB2
2S100 protein bindingGO:0445489.8S100B, S100A1
3p53 bindingGO:0020399.6TP63, TP53, MUC1
4receptor signaling protein tyrosine kinase activityGO:0047169.5EGFR, ERBB2
5protein phosphatase bindingGO:0199039.4EGFR, ERBB2, TP53
6identical protein bindingGO:0428028.2EGFR, TP63, TP53, PCNA, S100A1, S100B
7protein bindingGO:0055155.4S100A1, PCNA, MUC1, PGR, TP53, TP63

Products for genes affiliated with Sweat Gland Carcinoma

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Sources for Sweat Gland Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet