MCID: SWT001
MIFTS: 50

Sweat Gland Carcinoma malady

Endocrine diseases, Cancer diseases categories

Aliases & Classifications for Sweat Gland Carcinoma

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Aliases & Descriptions for Sweat Gland Carcinoma:

Name: Sweat Gland Carcinoma 8 61
Malignant Neoplasm of Sweat Gland 8 61
Primary Malignant Neoplasm of Sweat Gland 61
Malignant Tumor of the Sweat Gland 8
Carcinoma of the Sweat Gland 8
Sweat Gland Adenocarcinoma 61
Tumor of the Sweat Gland 8
 
Neoplasm of Sweat Gland 8
Sweat Gland Neoplasms 61
Sweat Gland Tumor Nos 8
Sweat Gland Neoplasm 8
Sweat Gland Cancer 8
Sweat Gland Tumor 8


Classifications:



Summaries for Sweat Gland Carcinoma

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MalaCards based summary: Sweat Gland Carcinoma, also known as malignant neoplasm of sweat gland, is related to syringocystadenoma papilliferum and eccrine porocarcinoma. An important gene associated with Sweat Gland Carcinoma is S100B (S100 calcium binding protein B), and among its related pathways are TP53 network and EGFR Transactivation by Gastrin. The compounds pd158780 and iressa have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and lymph node, and related mouse phenotypes are pigmentation and limbs/digits/tail.

Related Diseases for Sweat Gland Carcinoma

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Diseases related to Sweat Gland Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 185)
idRelated DiseaseScoreTop Affiliating Genes
1syringocystadenoma papilliferum31.2PIP
2eccrine porocarcinoma31.1MUC1
3hidradenoma31.1MUC1, PIP
4merkel cell carcinoma30.8KRT20, MUC1
5myoepithelioma30.4KRT14, S100B, S100A1, ACTC1, TP63
6spindle cell carcinoma30.4ACTC1, MUC1, PGR, TP63
7breast cancer30.4ERBB2, PCNA, PGR
8melanoma29.5KRT14, S100B, S100A1, PCNA, ACTC1, TP53
9papillary carcinoma29.4KRT20, KRT7, KRT14, ERBB2, S100A1, ACTC1
10mucoepidermoid carcinoma29.2EGFR, KRT13, KRT7, KRT14, S100A1, PCNA
11adenocarcinoma27.3EGF, EGFR, KRT13, KRT20, KRT7, KRT1
12gemistocytic astrocytoma10.6S100B
13hidrocystoma10.6PIP
14epithelial-myoepithelial carcinoma10.5KRT14
15inverted papilloma10.5KRT20
16rosai-dorfman disease10.5S100B
17metanephric adenoma10.5KRT7
18glomus tumor10.5S100A1, ACTC1
19langerhans-cell histiocytosis10.5S100B, S100A1
20supernumerary nipples10.5KRT20, PIP
21nephrogenic adenoma10.5KRT7, S100A1
22cystadenocarcinoma10.5MUC5AC, MUC1
23giant cell glioblastoma10.5EGFR
24fibrous meningioma10.4S100B, MUC1
25anaplastic ependymoma10.4S100B, MUC1
26cystadenoma10.4KRT7
27choroid plexus papilloma10.4S100B, MUC1
28granular cell tumor10.4S100B, S100A1
29secretory meningioma10.4KRT7, MUC1
30apocrine sweat gland neoplasm10.4
31bladder adenocarcinoma10.4KRT20, KRT7
32breast fibroadenoma10.4PGR
33fibrous histiocytoma10.4S100B, ACTC1
34ovarian brenner tumor10.4KRT20, KRT7
35eccrine sweat gland cancer10.4
36papilloma10.4KRT14, MUC5AC
37leiomyomatosis10.4PGR
38histiocytosis10.4S100B
39cutaneous fibrous histiocytoma10.4S100B, S100A1, ACTC1
40oxyphilic adenoma10.4KRT7, S100A1
41perineurioma10.4S100B, MUC1
42folliculitis10.4EGFR
43rhabdoid tumor10.4ACTC1, MUC1
44ganglioglioma10.4S100B
45keratoderma10.4KRT1, KRT14
46signet ring cell adenocarcinoma10.4KRT20, KRT7, PIP
47renal oncocytoma10.4KRT7, S100A1
48pseudomyxoma peritonei10.4KRT20, KRT7, MUC5AC
49fibroma10.4KRT1, S100A1, ACTC1
50giant cell tumor10.4S100B, ACTC1, MUC1

Graphical network of the top 20 diseases related to Sweat Gland Carcinoma:



Diseases related to sweat gland carcinoma

Symptoms for Sweat Gland Carcinoma

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Drugs & Therapeutics for Sweat Gland Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Sweat Gland Carcinoma

Search NIH Clinical Center for Sweat Gland Carcinoma

Genetic Tests for Sweat Gland Carcinoma

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Anatomical Context for Sweat Gland Carcinoma

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MalaCards organs/tissues related to Sweat Gland Carcinoma:

31
Breast, Skin, Lymph node, Lung, Bone, Kidney, Salivary gland

Animal Models for Sweat Gland Carcinoma or affiliated genes

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Publications for Sweat Gland Carcinoma

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Articles related to Sweat Gland Carcinoma:

(show top 50)    (show all 125)
idTitleAuthorsYear
1
Merkel cell carcinoma with glandular differentiation admixed with sweat gland carcinoma and spindle cell carcinoma: histogenesis of merkel cell carcinoma from hair follicle stem cells. (25699980)
2015
2
Primary Cutaneous Endocrine Mucin-Producing Sweat Gland Carcinoma Co-occurring Simultaneously With Low-Grade Ductal Mucinous Breast Cancer: A Clinicopathologic Conundrum. (25014107)
2014
3
Considerations before accepting an extra-facial location of endocrine mucin-producing sweat gland carcinoma. (25487867)
2014
4
Primary cutaneous sweat gland carcinoma. (25022402)
2014
5
Aggressiveness of poorly differentiated sweat gland carcinoma in kidney transplant recipient. (23829827)
2013
6
Mucin-producing sweat gland carcinoma of the eyelid: diagnostic and prognostic considerations. (23218693)
2013
7
Apocrine sweat gland carcinoma: initial evaluation, staging, and response monitoring using 18F-FDG PET/CT. (23377411)
2013
8
Endocrine mucin producing sweat gland carcinoma: a clinicopathological analysis of three cases. (22935981)
2012
9
Clinicopathologic characteristics of 12 patients with vulvar sweat gland carcinoma. (20606537)
2010
10
Sweat gland carcinoma - a case report. (21661469)
2010
11
Endocrine mucin-producing sweat gland carcinoma: report of a case and review of the literature. (17177942)
2006
12
Sweat gland carcinoma with lung metastases. (17998708)
2006
13
Endocrine mucin-producing sweat gland carcinoma: twelve new cases suggest that it is a precursor of some invasive mucinous carcinomas. (16160476)
2005
14
Treatment of synchronous mucinous carcinoma and endocrine mucin-producing sweat gland carcinoma with Mohs' micrographic surgery. (15841644)
2005
15
Sweat gland carcinoma. (14964551)
2004
16
Recurrent polymorphous sweat gland carcinoma of the skin. (12063490)
2002
17
Histiocytoid variant of eccrine sweat gland carcinoma of the eyelid and orbit: report of five cases. (11874761)
2002
18
Facial sweat gland carcinoma metastasizing to neck nodes: a diagnostic and therapeutic challenge. (11735822)
2001
19
Metastatic sweat gland carcinoma. (11762625)
2001
20
Apocrine sweat gland carcinoma. (11339615)
2001
21
Malignant apocrine sweat gland carcinoma of the caruncle. (12045959)
2000
22
Sweat gland carcinoma with multiple local recurrences: a case report. (10655575)
1999
23
Epidermal growth factor, estrogen, and progesterone receptor expression in primary sweat gland carcinomas and primary and metastatic mammary carcinomas. (10463481)
1999
24
Sweat gland carcinoma: a clinicopathologic analysis of an expanded series in a single institution. (9727435)
1998
25
Endocrine mucin-producing sweat gland carcinoma: a cutaneous neoplasm analogous to solid papillary carcinoma of breast. (9414195)
1997
26
Sweat gland carcinoma. (9149787)
1997
27
Sweat gland carcinoma in a human immunodeficiency virus-infected patient. (7539911)
1995
28
Prognostic value of immunohistochemical staining for proliferating cell nuclear antigen, p53, and c-erbB-2 in sebaceous gland carcinoma and sweat gland carcinoma: comparison with histopathological parameter. (7909154)
1994
29
A case of ductal sweat gland carcinoma connected to syringocystadenoma papilliferum arising in nevus sebaceus. (7699123)
1994
30
Giant primary mucinous sweat gland carcinoma of the scalp. (8403482)
1993
31
Sweat gland carcinoma with mucinous and infiltrating duct-like patterns. (1331212)
1992
32
Sweat gland carcinoma ex eccrine spiradenoma. (2847574)
1987
33
Mucinous (adenocystic) sweat gland carcinoma of the great toe. (2833541)
1987
34
Inguinal sweat gland carcinoma with choriocarcinomatous differentiation. (2425551)
1986
35
Axillary sweat gland carcinoma versus amelanotic malignant melanoma. (4089996)
1985
36
Extramammary Paget's disease. Arising in knee region in association with sweat gland carcinoma. (6205637)
1984
37
Metastasizing eccrine sweat gland carcinoma. Report of a case. (6721544)
1984
38
Sweat gland carcinoma with hypercalcemia. (7132372)
1982
39
Primary mucinous sweat gland carcinoma of the eyelid simulating metastatic carcinoma. (219696)
1979
40
Sustained complete remission of metastatic sweat gland carcinoma following regional hyperthermic perfusion. (660813)
1978
41
Metastatic sweat gland carcinoma. (703462)
1978
42
Sweat gland carcinoma: a clinico-pathological reappraisal. (1249938)
1976
43
Sweat gland carcinoma. Report of a case in an unusual location and review of literature. (4823258)
1974
44
Sweat gland carcinoma of the hand. (4825405)
1974
45
Sweat gland carcinoma arising in irradiated skin. (5011405)
1972
46
Sweat gland carcinoma: a clinico-pathologic study of 83 patients. (5100098)
1971
47
Apocrine sweat gland carcinoma. Report of a case. (5476740)
1970
48
APOCRINE GLAND CARCINOMA (SWEAT GLAND CARCINOMA) OF THE BREAST. (14119212)
1964
49
Metastasizing sweat-gland carcinoma; notes on the surgical therapy. (13636656)
1959
50
Sweat-gland carcinoma of eyelid. (14430109)
1959

Variations for Sweat Gland Carcinoma

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Expression for genes affiliated with Sweat Gland Carcinoma

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Search GEO for disease gene expression data for Sweat Gland Carcinoma.

Pathways for genes affiliated with Sweat Gland Carcinoma

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Pathways related to Sweat Gland Carcinoma according to GeneCards Suite gene sharing:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9TP63, TP53
2
Show member pathways
EGFR-dependent Endothelin signaling events36
9.8EGFR, EGF
3
Show member pathways
Development Ligand independent activation of ESR1 and ESR259
9.5ERBB2, EGFR, EGF
49.5ERBB2, EGF, EGFR
5
Show member pathways
Translation Non genomic rapid action of Androgen Receptor59
9.5EGFR, EGF, ERBB2
69.5EGFR, EGF, ERBB2
7
Show member pathways
9.5EGFR, ERBB2, EGF
89.5EGF, ERBB2, EGFR
9
Show member pathways
9.5TP53, ERBB2, EGFR
10
Show member pathways
9.5ERBB2, EGFR, TP53
119.5EGFR, ERBB2, TP53
129.4TP53, EGF, EGFR
139.4TP53, EGF, EGFR
149.4EGF, EGFR, TP53
15
Show member pathways
Delta-Notch Signaling Pathway36
Notch Signaling Pathway36
9.4EGFR, TP53, EGF
16
Show member pathways
9.4EGF, TP53, EGFR
17
Show member pathways
Development ERBB family signaling59
Development GDNF family signaling59
9.3MUC1, EGFR, EGF, ERBB2
189.2TP53, TP63, EGFR, ERBB2
19
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
9.2TP53, ERBB2, EGF, EGFR
20
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
9.2EGFR, ERBB2, TP53, EGF
21
Show member pathways
9.2EGFR, ERBB2, TP53, EGF
22
Show member pathways
Signaling Pathways in Glioblastoma36
9.2EGF, ERBB2, TP53, EGFR
239.2EGF, ERBB2, EGFR, TP53
24
Show member pathways
9.2EGFR, EGF, TP53, ERBB2
25
Show member pathways
9.0PGR, ERBB2, EGFR, EGF, S100B
269.0EGFR, TP63, TP53, PCNA
278.9TP53, MUC1, ERBB2, EGFR, EGF
288.9KRT13, KRT7, KRT1, KRT14
29
Show member pathways
8.7PIP, EGF, ERBB2, EGFR, TP53
30
Show member pathways
8.7ERBB2, PIP, EGFR, EGF, TP53
31
Show member pathways
Signal transduction PTEN pathway59
8.6ERBB2, EGFR, PCNA, EGF, TP53
328.6EGFR, EGF, TP53, PCNA, ERBB2
33
Show member pathways
8.5EGFR, TP53, MUC1, ERBB2, EGF, PIP

Compounds for genes affiliated with Sweat Gland Carcinoma

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Compounds related to Sweat Gland Carcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 143)
idCompoundScoreTop Affiliating Genes
1pd158780449.8ERBB2, EGFR, EGF
2iressa609.8EGFR, ERBB2, EGF
3ag 490609.8EGFR, ERBB2, EGF
4jnj 28871063 hydrochloride609.8EGF, EGFR, ERBB2
5ag 1478 hydrochloride609.8ERBB2, EGFR, EGF
6pertuzumab44 50 1111.7ERBB2, EGF, EGFR
7eosin449.7S100B, MUC1, PCNA
82-methoxyethanol449.7ACTC1, TP63, KRT14, S100A1
9pki-166449.6EGFR, EGF, ERBB2
10capecitabine44 50 1111.6EGFR, EGF, ERBB2, PGR
11lapatinib44 50 1111.5EGFR, ERBB2, PGR, EGF
12s 100449.5S100B, MUC1, ACTC1
13taxane449.5TP53, PGR, ERBB2, EGFR
144-hydroxytamoxifen449.4EGFR, EGF, PGR, ERBB2, S100B
15trastuzumab44 50 1111.3PGR, MUC1, EGF, EGFR, ERBB2
16progestin449.3EGF, EGFR, ERBB2, MUC1, PGR
17leucovorin44 50 1111.2EGFR, EGF, PGR, ERBB2
18geldanamycin44 50 60 1112.2EGF, ERBB2, EGFR, TP53, PGR
19fulvestrant44 50 28 1112.1ERBB2, EGF, EGFR, PCNA, PGR
20bromodeoxyuridine449.1TP63, EGF, KRT1, KRT14, PCNA, S100B
21biotin44 24 1111.0MUC1, S100A1, ACTC1, PCNA, ERBB2, KRT1
22reticulin448.9KRT7, S100B, PCNA, ACTC1, MUC1
23egcg448.9EGFR, ERBB2, PCNA, EGF, TP53
24gemcitabine44 50 1110.8EGF, PCNA, EGFR, TP53, ERBB2, MUC1
25proline448.6S100B, KRT14, MUC5AC, KRT1, KRT13, TP53
26paclitaxel44 50 1110.5EGFR, S100B, PCNA, PGR, TP53, EGF
27doxorubicin44 50 1110.3TP63, TP53, PGR, ERBB2, KRT20, EGFR
28cisplatin44 50 60 1111.3ERBB2, TP63, TP53, MUC1, PCNA, EGF
29dexamethasone44 50 28 1111.2PGR, MUC1, ERBB2, EGF, S100B, PCNA
30methotrexate50 44 1110.1MUC1, PGR, MUC5AC, PCNA, ERBB2, KRT7
31steroid448.1ERBB2, KRT1, EGF, ACTC1, S100B, MUC5AC
32retinoid448.0EGFR, KRT7, KRT1, MUC5AC, PGR, TP53
335fluorouracil448.0PGR, PCNA, TP53, ERBB2, EGFR, EGF
34formaldehyde44 249.0KRT7, KRT20, ERBB2, S100B, ACTC1, MUC1
35iron44 248.9ACTC1, S100A1, S100B, KRT14, KRT20, KRT7
36arginine447.9TP63, PCNA, S100B, KRT7, ERBB2, KRT14
37cysteine447.9EGF, S100B, MUC1, PGR, KRT14, MUC5AC
38tamoxifen44 50 28 1110.9PIP, TP53, PGR, MUC1, EGF, EGFR
39serine447.8S100B, ERBB2, EGFR, MUC1, EGF, KRT1
40calcium44 50 24 1110.6EGF, TP63, KRT13, KRT1, KRT14, S100A1
41mucicarmine447.4ACTC1, S100A1, S100B, KRT14, KRT7, KRT20
42b 723447.2PIP, TP63, MUC1, ACTC1, KRT20, PCNA
43hematoxylin446.6KRT20, TP63, MUC5AC, KRT7, KRT1, KRT14
44vegf446.4EGF, EGFR, KRT20, KRT7, ERBB2, S100B
45tyrosine446.1ERBB2, KRT20, MUC5AC, MUC1, TP63, KRT1
46retinoic acid44 246.6S100A1, PCNA, ACTC1, MUC5AC, MUC1, PGR
47testosterone44 60 24 118.6MUC5AC, MUC1, PGR, TP63, PIP, ACTC1
48paraffin444.6KRT14, ERBB2, S100B, S100A1, PCNA, ACTC1
49progesterone44 28 60 24 118.6ERBB2, KRT14, KRT1, KRT7, KRT20, EGFR
50estrogen444.5EGF, EGFR, KRT20, PGR, TP53, TP63

GO Terms for genes affiliated with Sweat Gland Carcinoma

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Cellular components related to Sweat Gland Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:00007909.3MUC1, TP53, TP63
2apical plasma membraneGO:00163249.2PIP, MUC1, ERBB2, EGFR
3keratin filamentGO:00450959.0KRT14, KRT1, KRT7, KRT13
4intermediate filamentGO:00058828.8KRT20, KRT7, KRT14
5extracellular spaceGO:00056158.6PIP, ACTC1, S100B, KRT1, EGFR, EGF
6extracellular vesicular exosomeGO:00700627.7EGF, PIP, MUC1, MUC5AC, ACTC1, PCNA
7cytoplasmGO:00057376.4TP63, TP53, MUC1, ACTC1, PCNA, S100B

Biological processes related to Sweat Gland Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:003157110.0TP53, TP63
2regulation of angiogenesisGO:004576510.0KRT1, ERBB2
3response to X-rayGO:00101659.9TP53, TP63
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.9MUC1, TP53, TP63
5positive regulation of catenin import into nucleusGO:00354139.9EGF, EGFR
6positive regulation of MAP kinase activityGO:00434069.7EGF, EGFR, ERBB2
7positive regulation of phosphorylationGO:00423279.7EGF, EGFR
8peptidyl-tyrosine phosphorylationGO:00181089.7ERBB2, EGFR, EGF
9negative regulation of apoptotic processGO:00430669.3TP63, TP53, ACTC1, EGFR
10fibroblast growth factor receptor signaling pathwayGO:00085439.2EGF, EGFR, ERBB2
11phosphatidylinositol-mediated signalingGO:00480159.2PCNA, ERBB2, EGFR, EGF
12cell proliferationGO:00082839.0TP53, PCNA, S100B, ERBB2, EGFR

Molecular functions related to Sweat Gland Carcinoma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:00050069.9EGFR, ERBB2
2S100 protein bindingGO:00445489.8S100B, S100A1
3p53 bindingGO:00020399.6TP63, TP53, MUC1
4receptor signaling protein tyrosine kinase activityGO:00047169.5EGFR, ERBB2
5protein phosphatase bindingGO:00199039.4EGFR, ERBB2, TP53
6identical protein bindingGO:00428028.2EGFR, TP63, TP53, PCNA, S100A1, S100B
7protein bindingGO:00055155.4S100A1, PCNA, MUC1, PGR, TP53, TP63

Sources for Sweat Gland Carcinoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet