MCID: SYD001
MIFTS: 40

Sydenham's Chorea malady

Rare diseases, Neuronal diseases categories

Summaries for Sydenham's Chorea

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NINDS:42 Sydenham chorea (SD) is a neurological disorder of childhood resulting from infection via (GABHS), the bacterium that causes rheumatic fever.

MalaCards based summary: Sydenham's Chorea, also known as sydenham chorea, is related to malaria and neuronitis. An important gene associated with Sydenham's Chorea is DYT21 (dystonia 21, torsion (autosomal dominant)), and among its related pathways are Spinal Cord Injury and CXCR3-mediated signaling events. The compounds 3-nitropropionic acid and groalpha have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and cortex.

Aliases & Classifications for Sydenham's Chorea

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Sources:
60UMLS, 41NIH Rare Diseases, 47Orphanet, 42NINDS, 26ICD10 via Orphanet
See all sources

Sydenham's Chorea, Aliases & Descriptions:

Name: Sydenham's Chorea 41
Sydenham Chorea 41 42 47
Primary Dystonia, Dyt21 Type 41 47
Dyt21 41 47
 
Rheumatic Chorea 60
St. Vitus Dance 41
Dystonia 21 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


External Ids:

Orphanet47 306734, 306731
ICD10 via Orphanet26 G24.1, I02.0, I02.9

Related Diseases for Sydenham's Chorea

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Diseases related to Sydenham's Chorea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1malaria10.5CXCL9
2neuronitis10.4
3pandas10.4
4dystonia 2110.3
5paracoccidioidomycosis10.2CXCL10, CXCL9
6allergic contact dermatitis10.2CXCL9, CXCL10
7torsion dystonia10.2
8mycosis fungoides10.2CXCL10, CXCL9
9hashimoto thyroiditis10.2
10rheumatic fever10.2
11purpura10.2
12thyroiditis10.2
13rheumatic encephalitis10.2
14saint vitus dance10.2
15uveitis10.2CXCL10, CXCL9
16pulmonary fibrosis, idiopathic10.2CXCL10, CXCL9
17neonatal hypoxic and ischemic brain injury10.2BDNF, TH
18central hypoventilation syndrome, congenital10.2BDNF, TH
19neurotic disorder10.2BDNF, TH
20dermatitis10.2CXCL10, CXCL9
21rett syndrome10.2TH, BDNF
22encephalitis10.2CXCL9, CXCL10
23autistic disorder10.2BDNF, TH
24psychotic disorder10.1TH, BDNF
25toxic encephalopathy10.1BDNF, TH
26sarcoidosis 110.1CXCL9, CXCL10
27mood disorder10.1BDNF, TH
28brain disease10.1CXCL10, TH
29prion disease10.1TH, BDNF
30dystonia10.1
31viral meningitis10.1CXCL10, CRP
32huntington disease10.1BDNF, TH
33nutritional deficiency disease10.1CRP, BDNF
34atopic dermatitis10.0BDNF, CXCL9, CXCL10
35stroke, ischemic10.0BDNF, CRP
36skin disease10.0CXCL10, CXCL9, BDNF
37meningitis10.0CRP, CXCL10
38arthropathy10.0CRP, CXCL10
39multiple sclerosis, disease progression, modifier of10.0BDNF, CXCL9, CXCL10
40wilms tumor10.0BDNF, TH
41periodontal disease10.0CXCL10, CRP
42parkinson disease, late-onset10.0TH, BDNF
43neuroblastoma10.0BDNF, TH
44bipolar disorder9.9BDNF, TH
45dementia9.9BDNF, CXCL10, TH
46herpes simplex9.9BDNF, CXCL10, TH
47breast cancer9.9CXCL10, CXCL9
48pulmonary disease, chronic obstructive9.9CXCL10, CRP
49hepatocellular carcinoma9.9TH, CXCL9, BDNF
50tuberculosis9.9CXCL10, CXCL9, CRP

Graphical network of the top 20 diseases related to Sydenham's Chorea:



Diseases related to sydenham's chorea

Symptoms for Sydenham's Chorea

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Drugs & Therapeutics for Sydenham's Chorea

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Drug clinical trials:

Search ClinicalTrials for Sydenham's Chorea

Search NIH Clinical Center for Sydenham's Chorea

Genetic Tests for Sydenham's Chorea

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Anatomical Context for Sydenham's Chorea

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MalaCards organs/tissues related to Sydenham's Chorea:

31
Brain, Heart, Cortex, Thyroid, Testes, Monocytes, Adrenal cortex

Animal Models for Sydenham's Chorea or affiliated genes

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Publications for Sydenham's Chorea

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Articles related to Sydenham's Chorea:

(show top 50)    (show all 216)
idTitleAuthorsYear
1
Acute and chronic corticosteroid treatment of ten patients with paralytic form of Sydenham's chorea. (22197452)
2012
2
Infusion of Sydenham's chorea antibodies in striatum with up-regulated dopaminergic receptors: a pilot study to investigate the potential of SC antibodies to increase dopaminergic activity. (22781496)
2012
3
Sydenham's chorea. (21496581)
2011
4
Serum levels of brain-derived neurotrophic factor in Sydenham's chorea. (20112124)
2010
5
The prevalence of neuropsychiatric disorders in Sydenham's chorea. (20304326)
2010
6
Sydenham's chorea in a girl with juvenile idiopathic arthritis treated with anti-TNFalpha therapy. (20014056)
2010
7
Sydenham's chorea as a presentation of Moyamoya disease. (20434690)
2010
8
Subtle cognitive deficits in adults with a previous history of Sydenham's chorea during childhood. (20235195)
2010
9
Blood levels of catecholamine metabolites and brain-derived neurotrophic factor in a case of Sydenham's chorea. (17965987)
2009
10
Images in clinical medicine. Pericardial calcification noted long after Sydenham's chorea. (19797285)
2009
11
Tubulin is a neuronal target of autoantibodies in Sydenham's chorea. (17513792)
2007
12
Sydenham's chorea: clinical observations from a Brazilian movement disorder clinic. (17240185)
2007
13
Functional brain imaging in Sydenham's chorea. (16948948)
2006
14
Randomized double-blind study with prednisone in Sydenham's chorea. (16638499)
2006
15
Nerve conduction study in Sydenham's chorea. (15551347)
2005
16
Serum from Sydenham's chorea patients modifies intracellular calcium levels in PC12 cells by a complement-independent mechanism. (15747354)
2005
17
Diagnostic role of 99mTc hexamethyl-propyleneamine oxime brain single photon emission computed tomography in Sydenham's chorea. (15310312)
2004
18
Sydenham's chorea--an entity in progress. (15326832)
2004
19
Distinguishing PANDAS from Sydenham's chorea: case report and review of the literature. (15261885)
2004
20
CSF and serum immune parameters in Sydenham's chorea: evidence of an autoimmune syndrome? (12620654)
2003
21
Sydenham's chorea in the age of MRI: a case report and review. (12160978)
2002
22
Comparison of the efficacy of carbamazepine, haloperidol and valproic acid in the treatment of children with Sydenham's chorea: clinical follow-up of 18 patients. (12131934)
2002
23
Brain SPECT imaging in Sydenham's chorea. (11960191)
2002
24
Anti-basal ganglia antibodies in acute and persistent Sydenham's chorea. (12136062)
2002
25
Sydenham's chorea--clinical and evolutive characteristics. (11836548)
2002
26
Persistent Sydenham's chorea. (10495042)
1999
27
Cardiac involvement in Sydenham's chorea: clinical and Doppler echocardiographic findings. (10565452)
1999
28
Is Sydenham's chorea an antiphospholipid syndrome? (18644307)
1998
29
Anti-nuclear antibodies in Sydenham's chorea. (9331621)
1997
30
Hair pulling in a patient with Sydenham's chorea. (9286203)
1997
31
Sydenham's chorea and schizophrenia: a case report. (7547648)
1995
32
Neuropsychiatric aspects of Sydenham's chorea: a case report. (8358529)
1993
33
Reversible striatal hypermetabolism in a case of Sydenham's chorea. (8341301)
1993
34
Sydenham's chorea: physical and psychological symptoms of St Vitus dance. (8464654)
1993
35
Increase in incidence of Sydenham's chorea in Sao Paulo, Brazil. (8326544)
1993
36
Sydenham's chorea. (2075007)
1990
37
Sodium valproate and baclofen for Sydenham's chorea. (6407124)
1983
38
Corticosteroids i Sydenham's chorea. (7203571)
1980
39
Sydenham's chorea: case report of a diagnostic dilemma. (645961)
1978
40
Pathogenesis of Sydenham's chorea. (66579)
1977
41
Psychological correlates of the course of Sydenham's chorea. Repeat evaluations of a case. (1165335)
1975
42
THE NATURAL HISTORY OF SYDENHAM'S CHOREA. REVIEW OF THE LITERATURE AND LONG-TERM EVALUATION WITH EMPHASIS ON CARDIAC SEQUELAE. (14247294)
1965
43
CONTRIBUTION TO THE STUDY OF SYDENHAM'S CHOREA. A SYSTEMATIZATION OF THE CLINICAL ASPECTS. (14286113)
1964
44
Sydenham's chorea. II. Effects of hormone therapy. (14360739)
1955
45
Diagnosis and treatment of Sydenham's chorea, with presentation of a case. (13271199)
1955
46
Two factors in the differentiation of rheumatic and non-rheumatic types of Sydenham's chorea; a study of 97 cases. (18151062)
1949
47
Psychological and social aspects of Sydenham's chorea. (18911105)
1948
48
Sydenham's chorea, a syndrome for differential diagnosis. (20260468)
1947
49
The Etiology of Sydenham's Chorea: Electroencephalographic Studies. (20322055)
1941
50
Enterococcus and Sydenham's Chorea. (20476019)
1934

Variations for Sydenham's Chorea

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Expression for genes affiliated with Sydenham's Chorea

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Search GEO for disease gene expression data for Sydenham's Chorea.

Pathways for genes affiliated with Sydenham's Chorea

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Compounds for genes affiliated with Sydenham's Chorea

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Compounds related to Sydenham's Chorea according to GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
13-nitropropionic acid439.8BDNF, TH
2groalpha439.8CXCL10, CXCL9
3dopac439.8BDNF, TH
4mhpg439.8TH, BDNF
5maoa439.8BDNF, TH
6homovanillic acid43 2410.8BDNF, TH
7quinine43 28 2 49 1213.8CXCL9, BDNF
8pramipexole43 28 49 1212.8TH, BDNF
91 methyl 4 phenylpyridinium439.8TH, BDNF
10selegiline43 1210.8BDNF, TH
11il 10439.8CXCL9, CXCL10
12quetiapine43 49 28 24 1213.8BDNF, TH
13tarc439.8CXCL10, CXCL9
14desipramine43 49 1211.8BDNF, TH
15methamphetamine43 49 1211.8TH, BDNF
16valproate439.8TH, BDNF
176-hydroxydopamine439.8TH, BDNF
18mptp439.8BDNF, TH
19ccl343 2810.8CXCL9, CXCL10
20ccl443 2810.7CXCL9, CXCL10
21ifn-alpha439.7CXCL9, CXCL10
22tetrodotoxin43 59 2811.6TH, BDNF
23ketamine43 28 1211.6BDNF, CRP
24levodopa43 1210.5TH, BDNF
25corticosterone43 59 2411.5BDNF, TH
26infliximab43 49 1211.5CXCL10, CRP
27haloperidol43 49 28 2 1213.4TH, BDNF
28neopterin439.4CXCL10, CRP
29morphine43 49 28 1212.3CXCL10, TH
30catecholamine439.3BDNF, TH
31forskolin43 49 1211.3BDNF, CXCL10, TH
32adenylate439.2TH, CXCL10, BDNF
33cyclic amp43 2410.2BDNF, CXCL10, TH
34kainate43 2810.1BDNF, TH
35endotoxin439.1CRP, CXCL9, CXCL10
36clozapine43 28 49 1212.0TH, CRP, BDNF
37norepinephrine43 24 1211.0BDNF, CRP, TH
38acetylcholine43 49 28 24 1213.0TH, CRP, BDNF
39ly294002439.0BDNF, CRP, TH
40iron43 2410.0TH, CRP, BDNF
41lactate439.0BDNF, CRP, TH
42cycloheximide438.9CXCL10, CRP, BDNF
43aspartate438.9BDNF, CRP, TH
44dexamethasone43 49 28 1211.9CXCL9, CXCL10, TH
45cholesterol43 28 24 1211.9BDNF, CRP, CXCL10
46histamine43 28 2410.8TH, CXCL10, CXCL9, BDNF
47testosterone43 59 24 1211.8BDNF, CRP, TH
48tyrosine438.6BDNF, CXCL9, CXCL10, TH
49creatinine438.6BDNF, CRP, CXCL9, CXCL10
50vegf438.0BDNF, CRP, CXCL9, CXCL10, TH

GO Terms for genes affiliated with Sydenham's Chorea

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Cellular components related to Sydenham's Chorea according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1synaptic vesicleGO:00080219.4BDNF, TH
2extracellular regionGO:00055767.9BDNF, CRP, CXCL9, CXCL10

Biological processes related to Sydenham's Chorea according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cAMP metabolic processGO:00308169.7CXCL9, CXCL10
2positive regulation of cAMP-mediated signalingGO:00439509.6CXCL10, CXCL9
3positive regulation of release of sequestered calcium ion into cytosolGO:00512819.6CXCL9, CXCL10
4regulation of cell proliferationGO:00421279.4CXCL9, CXCL10
5defense response to virusGO:00516079.4CXCL9, CXCL10
6chemotaxisGO:00069359.3CXCL10, CXCL9
7response to ethanolGO:00454719.1CRP, TH
8response to lipopolysaccharideGO:00324969.0CXCL10, TH
9response to hypoxiaGO:00016668.8BDNF, CRP, TH
10inflammatory responseGO:00069548.7CXCL10, CXCL9, CRP

Molecular functions related to Sydenham's Chorea according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00080099.4CXCL9, CXCL10
2CXCR3 chemokine receptor bindingGO:00482489.1CXCL9, CXCL10

Products for genes affiliated with Sydenham's Chorea

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Sources for Sydenham's Chorea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet