MCID: SYM002
MIFTS: 40

Sympathetic Ophthalmia malady

Categories: Eye diseases, Rare diseases, Immune diseases

Aliases & Classifications for Sympathetic Ophthalmia

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Sources:
10Disease Ontology, 12DISEASES, 51Orphanet, 36MeSH, 65UMLS, 27ICD10, 29ICD9CM, 59SNOMED-CT, 66UMLS via Orphanet, 28ICD10 via Orphanet, 37MESH via Orphanet
See all MalaCards sources

Aliases & Descriptions for Sympathetic Ophthalmia:

Name: Sympathetic Ophthalmia 10 12 51
Ophthalmia, Sympathetic 36 65
 
Sympathetic Uveitis 10 51

Characteristics:

Orphanet epidemiological data:

51
sympathetic ophthalmia:
Inheritance: Not applicable; Age of onset: All ages

Classifications:

Orphanet: 51 
Rare eye diseases


External Ids:

Disease Ontology10 DOID:12029
ICD1027 H44.13
ICD9CM29 360.11
MeSH36 D009879
SNOMED-CT59 75315001
Orphanet51 79098
UMLS via Orphanet66 C0029077
ICD10 via Orphanet28 H44.1
MESH via Orphanet37 D009879
UMLS65 C0029077

Summaries for Sympathetic Ophthalmia

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Wikipedia:68 Sympathetic ophthalmia (SO) is a bilateral diffuse granulomatous uveitis (a kind of inflammation) of... more...

MalaCards based summary: Sympathetic Ophthalmia, also known as ophthalmia, sympathetic, is related to meningitis and artery disease. An important gene associated with Sympathetic Ophthalmia is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways are OX40 Pathway and Cellular Transformation by HTLV1. Affiliated tissues include eye, breast and lung.

Related Diseases for Sympathetic Ophthalmia

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Diseases related to Sympathetic Ophthalmia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 365)
idRelated DiseaseScoreTop Affiliating Genes
1meningitis30.1IL10, TNF
2artery disease29.8HLA-DQA1, HLA-DRB1, TNF
3malaria29.3HLA-DRB1, IL10, LTA, TNF
4hepatitis10.4
5endotheliitis10.4
6colorectal adenoma10.4HLA-DRB1, LTA
7breast cancer10.3
8psoriasis10.3HLA-C, HLA-DRB1
9maculopapular lupus rash10.3HLA-DRB1, IL10
10hemorrhagic fever with renal syndrome10.3HLA-C, HLA-DRB1
11echinococcosis10.3HLA-DRB1, IL10
12nut allergy10.3HLA-DRB1, IL10
13hypersensitivity reaction type ii disease10.3HLA-C, HLA-DRB1
14ichthyosis-hypotrichosis-sclerosing cholangitis syndrome10.3HLA-C, HLA-DRB1
15dysgammaglobulinemia10.3IL10, LTA
16tucker syndrome10.3HLA-DQA1, HLA-DRB1
17pulmonary coin lesion10.2HLA-DQA1, HLA-DRB1
18allergic rhinitis10.2
19atherosclerosis10.2
20lymphoma10.2
21choroiditis10.2
22uveitis10.2
23hepatitis c10.2
24rhinitis10.2
25metanephric adenoma10.2HLA-DQA1, HLA-DRB1
26intrahepatic gall duct cancer10.2HLA-C, HLA-DRB1
27squamous cell papilloma10.2HLA-C, LTA
28schizophrenia10.2
29lung cancer10.2
30coronary artery disease10.2
31cystic fibrosis10.2
32insulin-like growth factor i10.2
33leukemia10.2
34sinusitis10.2
35colitis10.2
36atrial fibrillation10.2
37endocarditis10.2
38sarcoma10.2
39esophagitis10.2
40vascular disease10.2
41melanoma10.2
42cervicitis10.2
43dermatitis10.2
44endometriosis10.2
45syringomyelia10.2
46thyroiditis10.2
47neuronitis10.2
48peritonitis10.2
49muscular dystrophy10.2
50cardiac rupture10.2

Graphical network of the top 20 diseases related to Sympathetic Ophthalmia:



Diseases related to sympathetic ophthalmia

Symptoms for Sympathetic Ophthalmia

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Drugs & Therapeutics for Sympathetic Ophthalmia

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Drugs for Sympathetic Ophthalmia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
TriamcinoloneapprovedPhase 1, Phase 2448124-94-731307
Synonyms:
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione
11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11beta,16alpha,17alpha,21-Tetrahydroxy-9alpha-fluoro-1,4-pregnadiene-3,20-dione
124-94-7
4-08-00-03629 (Beilstein Handbook Reference)
83474-03-7
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-16-alpha-hydroxyprednisolone
9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy
9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-hydroxyprednisolone
9α-fluoro-16α-hydroxyprednisolone
AC-2072
AC1L1LDH
AC1Q5HJC
Adcortyl
Allernaze
Aristocort
Aristocort A
Aristocort Tablets
Aristogel
Aristospan
Azmacort
BPBio1_000154
BRD-K77554836-001-03-3
BRN 2341955
BSPBio_000140
Bio-0662
C21H27FO6
CHEMBL1451
CID31307
CL 19823
Celeste
Cinolone
Cinolone-T
D00385
D014221
DB00620
Delphicort
EINECS 204-718-7
EU-0101179
Fluoxiprednisolone
Fluoxyprednisolone
Flutex
Fougera
HMS1568G22
HMS2090D12
HSDB 3194
Kenacort
Kenacort (TN)
Kenacort-A
Kenacort-AG
Kenacort-Ag
Kenalog
Kenalog in Orabase
Kenalog-10
Kenalog-40
Kenalog-H
LS-698
Ledercort
Lopac0_001179
MLS000028542
MLS001066543
 
MLS002695935
MolPort-002-528-981
Mycolog
NCGC00021580-03
NCGC00021580-04
NCGC00021580-05
NCGC00021580-06
NCGC00021580-07
NCI60_000750
NSC 13397
NSC13397
Nasacort
Nasacort Aq
Nasacort Hfa
Omcilon
Omicilon
Oracort
Oralone
Orion
Polcortolon
Pregna-1,4-diene-3,20-dio
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)
Prestwick0_000120
Prestwick1_000120
Prestwick2_000120
Prestwick3_000120
Prestwick_438
Rodinolone
S1933_Selleck
SK-Triamcinolone
SMP1_000300
SMR000058333
SPBio_002079
Sk-Triamcinolone
T6376_SIGMA
TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))
Tiamcinolonum
Tiamcinolonum [INN-Latin]
Tri-Nasal
Triacet
Triacort
Triam-Tablinen
Triamcet
Triamcinalone
Triamcinlon
Triamcinolon
Triamcinolona
Triamcinolona [INN-Spanish]
Triamcinolone (JP15/USP/INN)
Triamcinolone Acetonide
Triamcinolone [USAN:INN:BAN:JAN]
Triamcinolone acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Triamcinolonum
Triamcinolonum [INN]
Trianex
Triatex
Tricortale
Triderm
Triesence
Trilone
Tristoject
Trymex
UNII-1ZK20VI6TY
Vetalog
Volon
Volon A
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ
ZINC03882036
droxypregna-1,4-diene-3,20-dione
ione
nchembio.2007.53-comp7
triamcinolone
2triamcinolone acetonidePhase 1, Phase 2448
3Triamcinolone diacetatePhase 1, Phase 2448
4Triamcinolone hexacetonidePhase 1, Phase 2448
5Anti-Inflammatory AgentsPhase 1, Phase 28478
6Immunosuppressive AgentsPhase 1, Phase 210422
7glucocorticoidsPhase 1, Phase 23896
8Immunologic FactorsPhase 1, Phase 218483
9Hormone AntagonistsPhase 1, Phase 210002
10HormonesPhase 1, Phase 211748
11Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 1, Phase 29988
12
Verteporfinapproved, investigational83129497-78-55362420
Synonyms:
Verteporfin
Verteporfina
 
Verteporfinum
Vertéporfine
Visudyne
13Dermatologic Agents4555
14Photosensitizing Agents374

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat UveitisCompletedNCT01789320Phase 1, Phase 2
2Safety and Efficacy of AIN457 in Noninfectious UveitisCompletedNCT00685399Phase 2
3Safety Study of Conventional Versus Micropulse Transscleral Cyclophotocoagulation in Treating End-Stage GlaucomaRecruitingNCT00349414Phase 1, Phase 2
4Adjunctive Photodynamic Therapy + Aflibercept vs. Afilbercept Alone for PDA in NV AMDNot yet recruitingNCT02457026

Search NIH Clinical Center for Sympathetic Ophthalmia


Cochrane evidence based reviews: ophthalmia, sympathetic

Genetic Tests for Sympathetic Ophthalmia

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Anatomical Context for Sympathetic Ophthalmia

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MalaCards organs/tissues related to Sympathetic Ophthalmia:

33
Eye, Breast, Lung, Skin, Endothelial, Heart, Colon

Animal Models for Sympathetic Ophthalmia or affiliated genes

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Publications for Sympathetic Ophthalmia

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Articles related to Sympathetic Ophthalmia:

(show top 50)    (show all 311)
idTitleAuthorsYear
1
Synuclein I^ protects Akt and mTOR and renders tumor resistance to Hsp90 disruption. (24954510)
2015
2
Shikonin blocks migration and invasion of human breast cancer cells through inhibition of matrix metalloproteinase-9 activation. (24789371)
2014
3
Pneumoconiosis and respiratory problems in dental laboratory technicians: Analysis of 893 dental technicians. (25216818)
2014
4
Relationships Between Psychological Factors, Pain and Disability in Complex Regional Pain Syndrome and Low Back Pain. (24135903)
2013
5
The introduction of fox rabies into Italy (2008-2011) was due to two viral genetic groups with distinct phylogeographic patterns. (23603764)
2013
6
Nucleic Acid Sensors and Type I Interferon Production in Systemic Lupus Erythematosus. (24109483)
2013
7
Novel oral anticoagulants for the prevention of thromboembolism in patients with atrial fibrillation. (23734359)
2013
8
Drugs to cure avian influenza infection--multiple ways to prevent cell death. (24091678)
2013
9
Loss of constitutive activity is correlated with increased thermostability of the human adenosine A2A receptor. (23489072)
2013
10
Angiotensin-converting enzyme gene insertion/deletion polymorphism studies in Asian Indian pregnant women biochemically identifies gestational diabetes mellitus. (24189507)
2013
11
Short stature in child with early-onset diabetes. (23644647)
2013
12
Monoclonal IgG Kappa gammopathy previous to hematopoietic stem cell transplantation in an infant with severe combined immunodeficiency. (23022654)
2012
13
"How sick must your mouse be? " - An analysis of the use of animal models in Huntington's disease research. (23215663)
2012
14
Descemet-stripping automated endothelial keratoplasty for vitrectomized cases with traumatic aniridia and aphakic bullous keratopathy. (23055672)
2012
15
Plasma exchange for induction and cyclosporine A for maintenance of remission in Wegener's granulomatosis--a clinical randomized controlled trial. (20577017)
2011
16
Myotonic dystrophy type 2 and autoimmune chronic gastritis: an incidental association? (21948056)
2011
17
Evaluation of a standardized protocol using lepirudin or argatroban for heparin-induced thrombocytopenia. (21902659)
2011
18
Variant angina in the setting of food-borne botulism. (22080123)
2011
19
von Willebrand factor variant p.Arg924Gln marks an allele associated with reduced von Willebrand factor and factor VIII levels. (20492463)
2010
20
Identification of a helical intermediate in trifluoroethanol-induced alpha-synuclein aggregation. (20947801)
2010
21
Genetic variants in SLC9A9 are associated with measures of attention-deficit/hyperactivity disorder symptoms in families. (20032819)
2010
22
Long-term AZT exposure alters the metabolic capacity of cultured human lymphoblastoid cells. (20106944)
2010
23
KRAS testing in metastatic colorectal cancer: implications on the use of biologic agents. (19632927)
2009
24
Insights on chronic-relapsing opsoclonus-myoclonus from a pilot study of mycophenolate mofetil. (19258290)
2009
25
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. (18372904)
2008
26
Nervous system physiology regulated by membrane estrogen receptors. (19317180)
2008
27
Central nervous system lymphoma in a patient with Sjogren's syndrome and autoimmune thyroiditis (Hashimoto's thyroiditis). (16941199)
2007
28
Bickerstaff's brainstem encephalitis: can it recur? (16442797)
2006
29
Changing composition of renal calculi in patients with neurogenic bladder. (16600738)
2006
30
The hepatocyte growth factor regulatory factors in human breast cancer. (14734471)
2004
31
Identification of candidate liver tumor suppressor genes from human 11p11.2 by transcription mapping of microcell hybrid cell lines. (12738998)
2003
32
Argyrophilic nucleolar organizer regions (AgNORs) in relation to p53 and bcl-2 protein expression in leukemia patients. (14689061)
2003
33
The p65/RelA subunit of NF-kappaB suppresses the sustained, antiapoptotic activity of Jun kinase induced by tumor necrosis factor. (12417721)
2002
34
The angiotensin-converting enzyme gene family: genomics and pharmacology. (11931993)
2002
35
Actions of endotoxin and morphine. (11727765)
2001
36
The folate cycle and disease in humans. (11169015)
2001
37
Specific and nonspecific enzymes involved in the catabolism of mononucleoside and dinucleoside polyphosphates. (11007995)
2000
38
Cellular immune response to retinal S-antigen and interphotoreceptor retinoid-binding protein fragments in Eales' disease patients. (9873227)
1999
39
Pellucid marginal corneal degeneration 12 years after penetrating keratoplasty for keratoconus. (9520207)
1998
40
Guanine nucleotide binding properties of Rac2 mutant proteins and analysis of the responsiveness to guanine nucleotide dissociation stimulator. (9012677)
1997
41
Purification and characterization of bitiscetin, a novel von Willebrand factor modulator protein from Bitis arietans snake venom. (8806626)
1996
42
Effects of botulinum toxin therapy in patients with adductor spasmodic dysphonia: acoustic, aerodynamic, and videoendoscopic findings. (1556889)
1992
43
Exaggerated ANF response to exercise in middle-aged vs. young runners. (2148749)
1990
44
Percutaneous transluminal balloon angioplasty in Takayasu's aortitis: persistent benefit over two years. (1972860)
1990
45
Studies on plasminogen activator inhibitor 1 levels in human breast cancer. (2379756)
1990
46
Lipoprotein(a) binds to fibronectin and has serine proteinase activity capable of cleaving it. (2531657)
1989
47
Surgical management of resistant congenital talipes equinovarus deformities. (7085691)
1982
48
Cystinuria--a case report. (7052855)
1981
49
A clinical approach to the choice of antimicrobial agents. Case number 13: acute pyelonephritis. (7351516)
1980
50
Surgical treatment of cutis verticis gyrata: a report of 2 cases. (890202)
1977

Variations for Sympathetic Ophthalmia

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Expression for genes affiliated with Sympathetic Ophthalmia

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Search GEO for disease gene expression data for Sympathetic Ophthalmia.

Pathways for genes affiliated with Sympathetic Ophthalmia

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Pathways related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathwaysScoreTop Affiliating Genes
19.5IL10, LTA
2
Show member pathways
9.2LTA, TNF
39.2LTA, TNF
4
Show member pathways
9.1IL10, TNF
59.1IL10, TNF
69.1IL10, TNF
79.1IL10, TNF
8
Show member pathways
9.0HLA-C, HLA-DQA1, HLA-DRB1
99.0HLA-C, HLA-DQA1, HLA-DRB1
109.0HLA-C, HLA-DQA1, HLA-DRB1
119.0HLA-DQA1, HLA-DRB1, IL10
128.8HLA-DRB1, IL10, TNF
13
Show member pathways
8.7IL10, LTA, TNF
148.7IL10, LTA, TNF
158.7IL10, LTA, TNF
168.7HLA-DQA1, HLA-DRB1, TNF
178.4HLA-C, HLA-DQA1, HLA-DRB1, IL10
18
Show member pathways
8.2HLA-C, IL10, LTA, TNF
198.1HLA-DQA1, HLA-DRB1, IL10, TNF
20
Show member pathways
8.1HLA-DQA1, HLA-DRB1, IL10, TNF
21
Show member pathways
8.1HLA-DQA1, HLA-DRB1, IL10, TNF
227.7HLA-C, HLA-DQA1, HLA-DRB1, LTA, TNF
23
Show member pathways
7.7HLA-C, HLA-DQA1, HLA-DRB1, LTA, TNF
24
Show member pathways
7.2HLA-C, HLA-DQA1, HLA-DRB1, IL10, LTA, TNF

GO Terms for genes affiliated with Sympathetic Ophthalmia

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Cellular components related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.6HLA-C, HLA-DQA1
2trans-Golgi network membraneGO:00325889.5HLA-DQA1, HLA-DRB1
3ER to Golgi transport vesicle membraneGO:00125078.7HLA-C, HLA-DQA1, HLA-DRB1

Biological processes related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:000250410.1HLA-DQA1, HLA-DRB1
2positive regulation of chronic inflammatory response to antigenic stimulusGO:00028769.8LTA, TNF
3receptor biosynthetic processGO:00328009.7IL10, TNF
4negative regulation of cytokine secretion involved in immune responseGO:00027409.7IL10, TNF
5defense response to Gram-positive bacteriumGO:00508309.6LTA, TNF
6negative regulation of growth of symbiont in hostGO:00441309.6IL10, TNF
7negative regulation of interleukin-6 productionGO:00327159.5IL10, TNF
8positive regulation of interferon-gamma productionGO:00327299.5LTA, TNF
9positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.5IL10, TNF
10antigen processing and presentationGO:00198829.4HLA-C, HLA-DQA1, HLA-DRB1
11positive regulation of apoptotic processGO:00430659.3LTA, TNF
12response to organic substanceGO:00100339.1IL10, TNF
13defense response to bacteriumGO:00427429.0IL10, TNF
14immune responseGO:00069558.8HLA-DRB1, IL10, TNF

Sources for Sympathetic Ophthalmia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet