MCID: SYM002
MIFTS: 46

Sympathetic Ophthalmia malady

Eye diseases, Rare diseases categories

Summaries for Sympathetic Ophthalmia

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Wikipedia:63 Sympathetic ophthalmia (SO) is a bilateral diffuse granulomatous uveitis (a kind of inflammation) of... more...

MalaCards based summary: Sympathetic Ophthalmia, also known as sympathetic uveitis, is related to behcet's disease and melanoma. An important gene associated with Sympathetic Ophthalmia is CRYAA (crystallin, alpha A), and among its related pathways are 14-3-3 and Regulation of BAD Activity and Canonical NF-kappaB pathway. The compounds dpa 1 and cdp571 have been mentioned in the context of this disorder. Affiliated tissues include eye and retina, and related mouse phenotypes are limbs/digits/tail and craniofacial.

Aliases & Classifications for Sympathetic Ophthalmia

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Sources:
9Disease Ontology, 47Orphanet, 60UMLS, 27ICD9CM, 55SNOMED-CT, 33MeSH, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Sympathetic Ophthalmia, Aliases & Descriptions:

Name: Sympathetic Ophthalmia 9 47
Sympathetic Uveitis 9 47
 
Ophthalmia, Sympathetic 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 47 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

47
sympathetic ophthalmia:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Disease Ontology9 DOID:12029
ICD9CM27 360.11
MeSH33 D009879
Orphanet47 79098
SNOMED-CT55 75315001
MESH via Orphanet34 D009879
ICD10 via Orphanet26 H44.1
UMLS via Orphanet61 C0029077

Related Diseases for Sympathetic Ophthalmia

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Diseases related to Sympathetic Ophthalmia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1behcet's disease30.4LTA, HLA-C, TNF
2melanoma30.0HLA-C, TNF, HLA-DRB1, IL10, TYRP1
3uveitis29.3TNF, LTA, IL10, CCL2, HLA-C, TNFRSF1A
4choroiditis10.7
5retinitis10.7
6endophthalmitis10.6
7cataract10.6
8retinal detachment10.6
9vogt-koyanagi-harada disease10.5
10blindness10.4
11blau syndrome10.4TNF
12leprosy10.4HLA-DRB1
13periapical granuloma10.4CCL2
14keratitis10.3
15neovascular glaucoma10.3
16chorioretinitis10.3
17periodic fever, familial10.2TNFRSF1A, TNF
18psoriatic arthritis10.2HLA-C, TNF
19skin disease10.2HLA-DRB1
20familial mediterranean fever, ar10.2TNFRSF1A, TNF
21toxic shock syndrome10.2TNF, LTA
22arthritis10.2TNFRSF1A, TNF
23extrinsic allergic alveolitis10.2TNFRSF1A, CCL2
24abdominal aortic aneurysm10.2CCL2, TNFRSF1A
25microphthalmia10.2TYRP1, CRYAA
26alopecia10.2
27panophthalmitis10.2
28diphtheria10.2
29cerebritis10.2
30conjunctival pigmentation10.2
31chorioretinal scar10.2
32hypopyon10.2
33purulent endophthalmitis10.2
34turner syndrome10.2
35vasculitis10.2
36acanthamoeba keratitis10.2
37acute respiratory distress syndrome10.2LTA, TNF
38alcoholic hepatitis10.2CCL2, TNF
39interstitial lung disease10.2TNF, CCL2
40selective iga deficiency disease10.1IL10, LTA
41lepromatous leprosy10.1LTA, IL10
42leishmaniasis10.1TNFRSF1A, IL10
43spondyloarthropathy 110.1TNFRSF1A, TNF
44visceral leishmaniasis10.1LTA, IL10
45thyroiditis10.1HLA-C, HLA-DRB1
46phacoanaphylactic uveitis10.1
47paracoccidioidomycosis10.1IL10, TNFRSF1A
48pulmonary sarcoidosis10.1TNF, LTA, CCL2
49common variable immunodeficiency10.1IL10, TNFRSF1A
50pregnancy loss, recurrent 110.0LTA, IL10

Graphical network of the top 20 diseases related to Sympathetic Ophthalmia:



Diseases related to sympathetic ophthalmia

Symptoms for Sympathetic Ophthalmia

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Drugs & Therapeutics for Sympathetic Ophthalmia

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Drug clinical trials:

Search ClinicalTrials for Sympathetic Ophthalmia

Search NIH Clinical Center for Sympathetic Ophthalmia

Genetic Tests for Sympathetic Ophthalmia

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Anatomical Context for Sympathetic Ophthalmia

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MalaCards organs/tissues related to Sympathetic Ophthalmia:

31
Eye, Retina

Animal Models for Sympathetic Ophthalmia or affiliated genes

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Publications for Sympathetic Ophthalmia

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Articles related to Sympathetic Ophthalmia:

(show top 50)    (show all 308)
idTitleAuthorsYear
1
Presumed sympathetic ophthalmia after scleral buckling surgery. (25383825)
2013
2
Reversible retinal changes in the acute stage of sympathetic ophthalmia seen on spectral domain optical coherence tomography. (21331811)
2011
3
Sympathetic ophthalmia: enucleation or evisceration? (21876595)
2011
4
A case of sympathetic ophthalmia presenting with extraocular symptoms and conjunctival pigmentation after repeated 23-gauge vitrectomy. (20662657)
2010
5
Sympathetic ophthalmia following postoperative endophthalmitis and evisceration. (20596271)
2010
6
Periocular injections of triamcinolone for sympathetic ophthalmia. (20572826)
2010
7
Development of sympathetic ophthalmia following globe injury. (20137482)
2009
8
Subretinal hypopyon in sympathetic ophthalmia. (19412871)
2009
9
Intravitreal steroid slow-release device replacing repeated intravitreal triamcinolone injections for sympathetic ophthalmia. (18850570)
2008
10
Sympathetic ophthalmia in Singapore: new trends in an old disease. (16028023)
2006
11
Sympathetic ophthalmia following postoperative bacterial endophthalmitis: a clinicopathologic study. (16490496)
2006
12
Bilateral exudative retinal detachments as initial presentation of sympathetic ophthalmia in Turner syndrome. (16883368)
2006
13
Repeated intravitreal triamcinolone acetonide for chronic sympathetic ophthalmia. (16704716)
2006
14
Intravitreal triamcinolone acetonide in sympathetic ophthalmia. (15756580)
2005
15
Immunopathology of progressive subretinal fibrosis: a variant of sympathetic ophthalmia. (15364234)
2004
16
Sympathetic ophthalmia associated with ocular and cerebral vasculitis: an angiographic and radiologic study. (12948320)
2003
17
Incidence of sympathetic ophthalmia after penetrating eye injury and choice of treatment. (12789598)
2002
18
Sympathetic ophthalmia after three pars plana vitrectomies without prior ocular injury. (10950423)
2000
19
Sympathetic ophthalmia associated with antecedent adherent leucoma--a rare association. (9686861)
1998
20
Immunogenetic study of sympathetic ophthalmia. (9062965)
1997
21
Chlorambucil therapy in sympathetic ophthalmia. (7709973)
1995
22
Sympathetic ophthalmia. (10155637)
1994
23
Successfully treated sympathetic ophthalmia with typical histological confirmation. (8485440)
1993
24
Sympathetic ophthalmia after cyclocryotherapy of neovascular glaucoma without ocular penetration. (8446333)
1993
25
Surgical treatment of sympathetic ophthalmia. (1794786)
1991
26
A historical review of sympathetic ophthalmia and its epidemiology. (2678549)
1989
27
Sympathetic ophthalmia following neodymium:YAG cyclotherapy. (2779962)
1989
28
Delayed onset sympathetic ophthalmia. (3670198)
1987
29
Histologic and immunopathologic findings in sympathetic ophthalmia. (3994570)
1985
30
Sympathetic ophthalmia. (6479777)
1984
31
Effect of corticosteroid treatment and enucleation on the visual prognosis of sympathetic ophthalmia. (6614106)
1983
32
Recent advances in sympathetic ophthalmia. (396680)
1979
33
Sympathetic ophthalmia. A long-term follow-up. (629672)
1978
34
Sympathetic ophthalmia in Canada. (4274314)
1972
35
Sympathetic ophthalmia after couching operation. (4668490)
1972
36
Lymphocyte-stimulating activity of ocular tissues in sympathetic ophthalmia. (5124018)
1971
37
Observations on sympathetic ophthalmia. (5904961)
1966
38
Sympathetic Ophthalmia: A Case Treated by Prolonged Use of Corticotropin and Adrenal Steroids. (16693596)
1960
39
Sympathetic ophthalmia controlled by continuous cortisone therapy over a four-year period. (13458314)
1957
40
Sympathetic ophthalmia treated with cortisone. (14923790)
1952
41
Sympathizing eye in sympathetic ophthalmia; a pathologic study. (12984910)
1952
42
Sympathetic ophthalmia. (15412255)
1950
43
The important complications of cataract surgery exclusive of sympathetic ophthalmia. (15407741)
1949
44
Malignant melanoma of the choroid with sympathetic ophthalmia. (18132900)
1949
45
Sympathetic ophthalmia or phacoanaphylaxis? (18874349)
1948
46
Case of Sympathetic Ophthalmia. (18736629)
1915
47
NOTE ON THE BLOOD IN SYMPATHETIC OPHTHALMIA. (20765685)
1911
48
SYMPATHETIC OPHTHALMIA. (20757901)
1898
49
Sympathetic Ophthalmia: A Historical Correction. (20747958)
1875
50
Manchester Eye Hospital: Sympathetic Ophthalmia - Complete Loss of Vision-Restoration of Sight by Operative Means. (21373119)
1842

Variations for Sympathetic Ophthalmia

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Expression for genes affiliated with Sympathetic Ophthalmia

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Search GEO for disease gene expression data for Sympathetic Ophthalmia.

Pathways for genes affiliated with Sympathetic Ophthalmia

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Pathways related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1TNFRSF1A
29.5TNFRSF1A, TNF
39.5TNFRSF1A, TNF
4
Show member pathways
9.5TNF, TNFRSF1A
59.5TNFRSF1A, TNF
69.5TNFRSF1A, TNF
7
Show member pathways
9.5HLA-DRB1, HLA-DQA1
89.4TNF, CCL2
99.3LTA, IL10
10
Show member pathways
9.2LTA, TNFRSF1A, TNF
11
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.2LTA, TNFRSF1A, TNF
12
Show member pathways
9.2TNF, TNFRSF1A, LTA
13
Show member pathways
9.2LTA, TNFRSF1A, TNF
14
Show member pathways
9.2TNF, TNFRSF1A, LTA
15
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.2LTA, TNFRSF1A, TNF
16
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.2LTA, TNFRSF1A, TNF
17
Show member pathways
9.2LTA, TNFRSF1A, TNF
189.2TNF, TNFRSF1A, LTA
19
Show member pathways
9.2LTA, TNFRSF1A, TNF
209.1TNF, IL10
219.1TNF, IL10
22
Show member pathways
9.0HLA-C, HLA-DQA1, HLA-DRB1
239.0HLA-C, HLA-DQA1, HLA-DRB1
249.0HLA-DRB1, HLA-DQA1, HLA-C
25
Show member pathways
9.0HLA-DRB1, HLA-DQA1, HLA-C
26
Show member pathways
IL27-mediated signaling events36
8.8LTA, IL10, TNF
278.8TNF, IL10, LTA
28
Show member pathways
8.7IL10, TNFRSF1A, TNF
298.7LTA, CCL2, TNFRSF1A, TNF
30
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
8.7LTA, CCL2, TNFRSF1A, TNF
318.7HLA-DQA1, HLA-DRB1, IL10
32
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
8.6TNF, CCL2, IL10
338.6TNF, CCL2, IL10
34
Show member pathways
8.5HLA-DQA1, HLA-DRB1, TNF, TNFRSF1A
358.5HLA-DRB1, TNF, IL10
368.4HLA-DQA1, HLA-DRB1, TNF, CCL2
37
Show member pathways
8.4HLA-C, HLA-DQA1, TNF, TNFRSF1A, LTA
388.2HLA-C, HLA-DQA1, HLA-DRB1, IL10
39
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.2IL10, CCL2, TNFRSF1A, TNF
40
Show member pathways
8.1HLA-DQA1, HLA-DRB1, TNF, IL10
41
Show member pathways
7.9TNF, TNFRSF1A, CCL2, IL10, LTA
42
Show member pathways
7.9TNF, TNFRSF1A, CCL2, IL10, LTA
43
Show member pathways
7.9TNF, TNFRSF1A, CCL2, IL10, LTA
44
Show member pathways
7.9TNF, TNFRSF1A, CCL2, IL10, LTA
45
Show member pathways
7.9TNF, TNFRSF1A, CCL2, IL10, LTA
467.7HLA-C, HLA-DQA1, HLA-DRB1, TNF, TNFRSF1A, LTA
47
Show member pathways
7.7IL10, TNFRSF1A, TNF, HLA-DRB1, HLA-DQA1
487.7HLA-DQA1, HLA-DRB1, TNF, TNFRSF1A, IL10
49
Show member pathways
7.2HLA-C, HLA-DQA1, HLA-DRB1, TNF, TNFRSF1A, CCL2
50
Show member pathways
6.9LTA, HLA-C, HLA-DQA1, HLA-DRB1, TNF, TNFRSF1A

Compounds for genes affiliated with Sympathetic Ophthalmia

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Compounds related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1dpa 1439.7HLA-DRB1, HLA-DQA1
2cdp571439.2TNF, IL10
3cyclosporine49 1210.2LTA, IL10, TNF
4rantes439.2IL10, TNFRSF1A, CCL2
5blys439.1TNF, TNFRSF1A, IL10
6interferon gamma439.1IL10, TNF
7adalimumab43 49 1211.1TNF, TNFRSF1A, IL10
8mycophenolate mofetil43 49 1211.1IL10, LTA, TNF
9herbimycin a43 5910.1TNF, LTA, CCL2, TNFRSF1A
10fmlp439.1TNFRSF1A, LTA, CCL2, TNF
11pentoxifylline43 1210.0TNF, LTA, IL10
12mip 1alpha439.0TNF, CCL2, IL10
13il-12439.0IL10, CCL2, TNF
145 aminosalicylic acid439.0IL10, CCL2, TNF
15polymyxin b439.0TNF, IL10, CCL2
16groalpha439.0CCL2, TNF, IL10
17gm-csf43 2810.0CCL2, TNF, IL10
188-isoprostane438.9IL10, CCL2, TNF
19tarc438.9IL10, CCL2, TNF
20ccl343 289.9TNF, CCL2, IL10
21actinomycin d438.8LTA, TNFRSF1A, CCL2, TNF
22okt3438.8TNF, TNFRSF1A, IL10, LTA
23etanercept43 49 1210.8IL10, TNF, LTA, TNFRSF1A
24infliximab43 49 1210.8TNFRSF1A, TNF, IL10, LTA
25ivig438.8IL10, TNFRSF1A, LTA, TNF
26neopterin438.8TNF, TNFRSF1A, LTA, IL10
27thalidomide43 49 59 1211.8IL10, TNFRSF1A, TNF
2815-deoxy-delta-12,14-prostaglandin j2438.8IL10, CCL2, TNF
29ionomycin438.8TNF, TNFRSF1A, LTA, IL10
30chloroquine43 2 49 28 1212.7TNFRSF1A, IL10, TNF
31calcitriol43 59 24 1211.7TNF, TNFRSF1A, IL10, LTA
32toxin-1438.7TNF, IL10, CCL2, LTA
33lipoteichoic acid438.7TNF, CCL2, IL10, LTA
34il 10438.7LTA, TNF, CCL2, IL10
35simvastatin43 49 59 28 24 1213.6CCL2, TNFRSF1A, TNF, IL10
36prostacyclin438.6TNFRSF1A, TNF, CCL2, IL10
37sb 20358043 599.5TNFRSF1A, CCL2, TNF, IL10
38aspartate438.4IL10, HLA-DQA1, CRYAA, CCL2, TNFRSF1A
39methotrexate49 43 1210.4IL10, HLA-DRB1, TNFRSF1A, TNF
40paraffin438.4TNFRSF1A, HLA-DQA1, LTA, CCL2, IL10
41tgf beta1438.3CCL2, LTA, TNF, IL10, TNFRSF1A
42endotoxin438.3CCL2, TNFRSF1A, TNF, LTA, IL10
43pge2438.3TNF, TNFRSF1A, CCL2, IL10, LTA
44oxygen43 249.3CCL2, TNFRSF1A, TNF, TYRP1, LTA
45serine438.3LTA, TNF, TYRP1, CCL2, TNFRSF1A, CRYAA
46cycloheximide438.2TNF, LTA, IL10, TNFRSF1A, CCL2
47dexamethasone43 49 28 1211.2CCL2, TNFRSF1A, TNF, LTA, IL10
48vegf438.1TNF, TNFRSF1A, CCL2, IL10, LTA
49nitric oxide43 24 1210.1IL10, LTA, TNF, TNFRSF1A, CCL2
50cyclosporin a43 28 5910.1IL10, TNF, LTA, TNFRSF1A

GO Terms for genes affiliated with Sympathetic Ophthalmia

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Cellular components related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.5HLA-DRB1, HLA-DQA1
2transport vesicle membraneGO:00306589.5HLA-DQA1, HLA-DRB1
3endocytic vesicle membraneGO:00306669.5HLA-DRB1, HLA-DQA1
4clathrin-coated endocytic vesicle membraneGO:00306699.4HLA-DRB1, HLA-DQA1, TYRP1
5trans-Golgi network membraneGO:00325889.4HLA-DRB1, HLA-DQA1
6integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.3HLA-DRB1, HLA-DQA1, HLA-C
7ER to Golgi transport vesicle membraneGO:00125079.2HLA-C, HLA-DQA1, HLA-DRB1
8cell surfaceGO:00099868.8TNFRSF1A, TNF, HLA-C
9Golgi membraneGO:00001398.7TNFRSF1A, HLA-DRB1, HLA-DQA1, HLA-C
10integral component of plasma membraneGO:00058878.2HLA-C, HLA-DQA1, HLA-DRB1, TNF, TNFRSF1A
11extracellular spaceGO:00056158.0LTA, IL10, CCL2, TNFRSF1A, TNF

Biological processes related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chronic inflammatory response to antigenic stimulusGO:000287610.0LTA, TNF
2positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00029259.9LTA, TNF
3response to amino acidGO:00432009.8CCL2, TNFRSF1A
4positive regulation of synaptic transmissionGO:00508069.7TNF, CCL2
5defense response to Gram-positive bacteriumGO:00508309.7TNF, LTA
6lipopolysaccharide-mediated signaling pathwayGO:00316639.7TNF, CCL2
7extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.6TNF, TNFRSF1A
8protein kinase B signalingGO:00434919.6CCL2, TNF
9positive regulation of interferon-gamma productionGO:00327299.6LTA, TNF
10cellular response to organic cyclic compoundGO:00714079.6TNF, CCL2
11negative regulation of gene expressionGO:00106299.6CRYAA, TNFRSF1A, TNF
12cellular response to estradiol stimulusGO:00713929.5IL10, TNFRSF1A
13receptor biosynthetic processGO:00328009.5TNF, IL10
14negative regulation of cytokine secretion involved in immune responseGO:00027409.4TNF, IL10
15response to mechanical stimulusGO:00096129.4CCL2, TNF
16humoral immune responseGO:00069599.4LTA, CCL2, TNF
17positive regulation of cytokine secretionGO:00507159.4TNF, IL10
18interferon-gamma-mediated signaling pathwayGO:00603339.4HLA-DRB1, HLA-DQA1, HLA-C
19negative regulation of interferon-gamma productionGO:00326899.3HLA-DRB1, IL10
20intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.2TNFRSF1A, TNF
21negative regulation of T cell proliferationGO:00421309.2IL10, HLA-DRB1
22negative regulation of growth of symbiont in hostGO:00441309.2TNF, IL10, LTA
23negative regulation of interleukin-6 productionGO:00327159.1IL10, TNFRSF1A, TNF
24response to activityGO:00148239.0TNF, CCL2, IL10
25immune responseGO:00069558.9HLA-C, HLA-DQA1, HLA-DRB1
26response to hypoxiaGO:00016668.8LTA, CRYAA, CCL2, TNFRSF1A, TNF
27response to glucocorticoidGO:00513848.7TNF, CCL2, IL10, CRYAA
28inflammatory responseGO:00069548.5TNF, TNFRSF1A, CCL2, IL10
29cytokine-mediated signaling pathwayGO:00192218.5HLA-C, HLA-DQA1, HLA-DRB1, TNFRSF1A, CCL2
30response to drugGO:00424938.3LTA, CRYAA, IL10, CCL2, TNF

Molecular functions related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323959.5HLA-DRB1, HLA-DQA1
2tumor necrosis factor receptor bindingGO:00051649.5TNF, LTA
3receptor bindingGO:00051029.2LTA, CCL2, HLA-C
4peptide antigen bindingGO:00426059.1HLA-DRB1, HLA-C
5cytokine activityGO:00051258.8LTA, IL10, TNF

Products for genes affiliated with Sympathetic Ophthalmia

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Sources for Sympathetic Ophthalmia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet