MCID: SYM002
MIFTS: 51

Sympathetic Ophthalmia malady

Eye diseases category

Summaries for Sympathetic Ophthalmia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Sympathetic ophthalmia (SO) is a bilateral diffuse granulomatous uveitis (a kind of inflammation) of... more...

MalaCards: Sympathetic Ophthalmia, also known as sympathetic uveitis, is related to vogt-koyanagi-harada disease and melanoma. An important gene associated with Sympathetic Ophthalmia is TYRP1 (tyrosinase-related protein 1), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The compounds endotoxin and ivig have been mentioned in the context of this disorder. Affiliated tissues include eye and retina, and related mouse phenotypes are vision/eye and skeleton.

Aliases & Classifications for Sympathetic Ophthalmia

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8Disease Ontology, 48Orphanet, 60UMLS, 34MeSH, 27ICD9CM, 56SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Characteristics (Orphanet epidemiological data):

48
sympathetic ophthalmia:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Variable


Aliases & Descriptions:

sympathetic ophthalmia 8 48
sympathetic uveitis 8 48
ophthalmia, sympathetic 60


External Ids:

Disease Ontology8 DOID:12029
MeSH34 D009879
ICD9CM27 360.11
MESH via Orphanet35 D009879
SNOMED-CT56 75315001
ICD10 via Orphanet26 H44.1
SNOMED-CT via Orphanet57 75315001
UMLS via Orphanet61 C0029077

Related Diseases for Sympathetic Ophthalmia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Sympathetic Ophthalmia:



Diseases related to sympathetic ophthalmia

Clinical Features for Sympathetic Ophthalmia

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Drugs & Therapeutics for Sympathetic Ophthalmia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Sympathetic Ophthalmia

Drug clinical trials:

Search ClinicalTrials for Sympathetic Ophthalmia

Search NIH Clinical Center for Sympathetic Ophthalmia

Search CenterWatch for Sympathetic Ophthalmia

Genetic Tests for Sympathetic Ophthalmia

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Anatomical Context for Sympathetic Ophthalmia

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32MalaCards
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MalaCards organs/tissues related to Sympathetic Ophthalmia:

32
Eye, Retina

Animal Models for Sympathetic Ophthalmia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sympathetic Ophthalmia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.7TYRP1, CRYAA
2MP:00053909.5TYRP1, LTA, TNFRSF1A
3MP:00020068.0CCL2, TNFRSF1A, TNF, TYRP1, IL10
4MP:00053707.8CCL2, TNFRSF1A, TNF, LTA, IL10
5MP:00053977.7IL10, LTA, HLA-DQA1, TNF, TNFRSF1A, CCL2

Publications for Sympathetic Ophthalmia

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50PubMed
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Articles related to Sympathetic Ophthalmia:

(show top 50)    (show all 297)
idTitleAuthorsYear
1
Multimodality diagnostic imaging in a case of sympathetic ophthalmia. (22594960)
2012
2
Reversible retinal changes in the acute stage of sympathetic ophthalmia seen on spectral domain optical coherence tomography. (21331811)
2011
3
A case of sympathetic ophthalmia after a severe acanthamoeba keratitis. (21471815)
2011
4
Challenges of managing sympathetic ophthalmia in a young child and the role of infliximab. (21732578)
2011
5
Periocular injections of triamcinolone for sympathetic ophthalmia. (20572826)
2010
6
Intravitreal steroid slow-release device replacing repeated intravitreal triamcinolone injections for sympathetic ophthalmia. (18850570)
2008
7
Recurrent neovascularization of the disc in sympathetic ophthalmia. (18417828)
2008
8
Sympathetic ophthalmia after a hyphema due to nonpenetrating trauma. (15804775)
2005
9
Sympathetic ophthalmia. (16282154)
2005
10
Cataract surgery in sympathetic ophthalmia. (15519091)
2004
11
Changing trends in sympathetic ophthalmia. (15498072)
2004
12
Sympathetic ophthalmia associated with ocular and cerebral vasculitis: an angiographic and radiologic study. (12948320)
2003
13
Sympathetic ophthalmia after complicated cataract surgery and intraocular lens implantation. (11456026)
2001
14
Sympathetic ophthalmia: a case report and review of the need for prophylactic enucleation. (10321321)
1999
15
Indocyanine green angiographic findings in sympathetic ophthalmia. (9717662)
1998
16
Immunogenetic study of sympathetic ophthalmia. (9062965)
1997
17
Sympathetic ophthalmia. (7490178)
1995
18
Sympathetic ophthalmia following laser cyclocoagulation. (8285899)
1994
19
Report of a case of sympathetic ophthalmia with special regard to ultrastructural examination. (8033612)
1993
20
Presumed Sympathetic Ophthalmia Following Nd: YAG Transscleral Cyclophotocoagulation. (19920480)
1993
21
Sympathetic ophthalmia and subretinal neovascularization. (2369029)
1990
22
Long-term follow-up of sympathetic ophthalmia treated by combination of Chinese traditional and Western medicine. (3412019)
1988
23
Choroiditis compatible with the histopathologic diagnosis of sympathetic ophthalmia following cyclocryotherapy of neovascular glaucoma. (3353083)
1988
24
Anti-retinal auto-antibodies in Vogt-Koyanagi-Harada syndrome, Behcet's disease, and sympathetic ophthalmia. (3900848)
1985
25
Morphological variation of DalAcn-Fuchs nodules in sympathetic ophthalmia. (3978066)
1985
26
Sympathetic ophthalmia. (6479777)
1984
27
Sympathetic ophthalmia simulating vogt-Koyanagi-Harada's disease: a clinico-pathologic study of four cases. (6656012)
1983
28
Histocompatibility antigens in sympathetic ophthalmia. (6824052)
1983
29
Clinical and histopathological report of sympathetic ophthalmia after retinal detachment surgery. (6824620)
1983
30
Pigmentation associated histopathological variations in sympathetic ophthalmia. (7387955)
1980
31
Study on cellular immune response after complicated cataract operations and in sympathetic ophthalmia. (303873)
1977
32
Observations on sympathetic ophthalmia. (5828626)
1965
33
Sympathetic ophthalmia following iridencleisis. Case report and incidence. (13711716)
1961
34
Modern therapy of sympathetic ophthalmia. (13765639)
1960
35
Sympathetic ophthalmia controlled by continuous cortisone therapy over a four-year period. (13458314)
1957
36
The Vogt-Koyanagi syndrome: a variant of sympathetic ophthalmia; report of two cases. (13402850)
1957
37
Sympathetic ophthalmia. (13080376)
1953
38
Four cases of sympathetic ophthalmia, three cured, one under treatment. (13050370)
1953
39
Sympathizing eye in sympathetic ophthalmia; a pathologic study. (12984910)
1952
40
ACTH in the treatment of sympathetic ophthalmia. (14846580)
1951
41
Sympathetic ophthalmia following purulent endophthalmitis (postcataract extraction). (14877974)
1951
42
Sympathetic ophthalmia; a case report. (14878444)
1951
43
PARTICIPATION OF THE OCULAR APPENDAGES IN SYMPATHETIC OPHTHALMIA AND ITS BEARING ON ENUCLEATION. (18170493)
1948
44
Sympathetic Ophthalmia. (19985220)
1926
45
CATARACT EXTRACTION FOLLOWED BY SYMPTOMS SUGGESTIVE OF SYMPATHETIC OPHTHALMIA. (20770992)
1923
46
The Diagnostic and Therapeutic Use of Uveal Pigment in Injuries of the Uveal Tract and Sympathetic Ophthalmia. (16692604)
1922
47
Sympathetic Ophthalmia from which a Secondary Cataract had been removed after the Administration of Salvarsan. (19978235)
1914
48
NOTE ON THE BLOOD IN SYMPATHETIC OPHTHALMIA. (20765685)
1911
49
The Use of Serum in Sympathetic Ophthalmia. (16692222)
1911
50
Manchester Eye Hospital: Sympathetic Ophthalmia - Complete Loss of Vision-Restoration of Sight by Operative Means. (21373119)
1842

Genetic Variations for Sympathetic Ophthalmia

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Expression for genes affiliated with Sympathetic Ophthalmia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sympathetic Ophthalmia

Search GEO for disease gene expression data for Sympathetic Ophthalmia.

Pathways for genes affiliated with Sympathetic Ophthalmia

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 52R&D Systems, 55SinoBiological
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Pathways related to Sympathetic Ophthalmia according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2LTA
2
Hide members
10.1TNFRSF1A
39.9HLA-DRB1
4
Hide members
9.8TNFRSF1A, LTA
59.6IL10, LTA
6
Hide members
9.5HLA-DRB1, HLA-DQA1
79.3TNFRSF1A, TNF
8
Hide members
9.3TNF, TNFRSF1A
99.3TNFRSF1A, HLA-C, HLA-DQA1
109.2TNF, CCL2
119.0HLA-DQA1, HLA-DRB1, HLA-C
129.0HLA-C, HLA-DRB1, HLA-DQA1
139.0TNFRSF1A, TNF, LTA
14
Hide members
9.0TNFRSF1A, TNF, LTA
15
Hide members
9.0TNFRSF1A, TNF, LTA
16
Hide members
9.0LTA, TNF, TNFRSF1A
17
Hide members
9.0LTA, TNF, TNFRSF1A
18
Hide members
9.0LTA, TNF, TNFRSF1A
19
Hide members
9.0LTA, TNF, TNFRSF1A
20
Hide members
9.0LTA, TNF, TNFRSF1A
219.0LTA, TNF, TNFRSF1A
229.0IL10, HLA-DQA1, HLA-DRB1
23
Hide members
8.8IL10, LTA, TNF
248.8IL10, LTA, TNF
25
Hide members
8.8IL10, TNF, TNFRSF1A
26
Development PDGF signaling via STATs and NF-kB
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8.7IL10, TNF, CCL2
278.6CCL2, TNFRSF1A, TNF, LTA
28
Hide members
8.6CCL2, TNFRSF1A, TNF, LTA
298.5HLA-C, HLA-DRB1, HLA-DQA1, IL10
30
Hide members
8.4CCL2, TNFRSF1A, TNF, IL10
31
Hide members
8.3TNFRSF1A, TNF, HLA-DRB1, HLA-DQA1
32
Hide members
8.2LTA, HLA-DQA1, HLA-C, TNF, TNFRSF1A
33
Hide members
8.1TNF, HLA-DRB1, HLA-DQA1, IL10
34
Hide members
8.1CCL2, TNFRSF1A, TNF, LTA, IL10
35
Hide members
8.1CCL2, TNFRSF1A, TNF, LTA, IL10
367.8IL10, HLA-DQA1, HLA-DRB1, TNF, TNFRSF1A
37
Hide members
7.1CCL2, TNFRSF1A, TNF, HLA-C, HLA-DRB1, HLA-DQA1
38
Hide members
7.0IL10, TNFRSF1A, TNF, HLA-C, HLA-DRB1, HLA-DQA1

Compounds for genes affiliated with Sympathetic Ophthalmia

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Sympathetic Ophthalmia according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.6TNFRSF1A
2ivig4410.6TNFRSF1A
3cycloheximide4410.5LTA
4pentoxifylline44 1111.5LTA
5dexamethasone44 49 28 1113.5LTA
6cyclosporin a44 28 5912.3LTA
7bcma4410.1TNFRSF1A
8aspartate449.9CRYAA, CCL2
9prednisolone44 28 1111.9LTA
10dpa 1449.8HLA-DRB1, HLA-DQA1
11gm-csf44 2810.5TNF, IL10
12cdp571449.4IL10, TNF
13rantes449.4TNF, LTA, TNFRSF1A
14interferon gamma449.4TNF, IL10
15blys449.2TNFRSF1A, IL10, TNF
16n-tosyl-l-phenylalanine chloromethyl ketone449.1TNF, CCL2
17mip 1alpha449.1CCL2, TNF, IL10
185 aminosalicylic acid449.1IL10, TNF, CCL2
19il-12449.1TNF, CCL2, IL10
20polymyxin b449.1IL10, TNF, CCL2
21groalpha449.1CCL2, IL10, TNF
228-isoprostane449.1CCL2, IL10, TNF
23tarc449.1IL10, TNF, CCL2
24ccl344 2810.1CCL2, TNF, IL10
25sp 60012544 5910.0TNFRSF1A, CCL2, TNF
26thalidomide44 49 59 1112.0IL10, TNF, TNFRSF1A
27chloroquine44 2 49 28 1113.0TNF, TNFRSF1A, IL10
2815-deoxy-delta-12,14-prostaglandin j2449.0IL10, CCL2, TNF
29herbimycin a44 5910.0LTA, TNF, CCL2, TNFRSF1A
30okt3448.9TNF, TNFRSF1A, IL10, LTA
31paraffin448.9CCL2, HLA-DQA1, LTA, IL10, TNFRSF1A
32etanercept44 49 1110.9TNF, IL10, LTA, TNFRSF1A
33infliximab44 49 1110.9TNFRSF1A, TNF, LTA, IL10
34neopterin448.9TNFRSF1A, TNF, LTA, IL10
35ionomycin448.9TNFRSF1A, TNF, LTA, IL10
36toxin-1448.9TNF, IL10, LTA, CCL2
37lipoteichoic acid448.8IL10, LTA, TNF, CCL2
38il 10448.8CCL2, TNF, LTA, IL10
39calcitriol44 59 11 2411.8IL10, TNF, TNFRSF1A, LTA
40simvastatin44 49 59 28 11 2413.8IL10, TNF, TNFRSF1A, CCL2
41actinomycin d448.8TNFRSF1A, TNF, LTA, CCL2
42prostacyclin448.8CCL2, TNFRSF1A, TNF, IL10
43atorvastatin44 49 28 11 2412.7IL10, TNF, CCL2
44sb 20358044 599.7IL10, TNF, TNFRSF1A, CCL2
45oxygen44 249.7TNFRSF1A, TYRP1, TNF, CCL2
46methotrexate44 49 1110.5TNF, IL10, TNFRSF1A, HLA-DRB1
47tgf beta1448.5IL10, CCL2, TNFRSF1A, TNF, LTA
48vegf448.3TNFRSF1A, CCL2, TNF, IL10, LTA
49nitric oxide44 11 2410.3IL10, LTA, TNF, CCL2, TNFRSF1A
50serine447.9TYRP1, CRYAA, TNF, TNFRSF1A, CCL2, LTA

GO Terms for genes affiliated with Sympathetic Ophthalmia

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16Gene Ontology
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Cellular components related to Sympathetic Ophthalmia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.5HLA-DQA1, HLA-DRB1
2clathrin-coated endocytic vesicle membraneGO:0306699.3TYRP1, HLA-DQA1, HLA-DRB1
3integral to lumenal side of endoplasmic reticulum membraneGO:0715569.1HLA-C, HLA-DRB1, HLA-DQA1
4ER to Golgi transport vesicle membraneGO:0125079.1HLA-DQA1, HLA-DRB1, HLA-C
5Golgi membraneGO:0001398.6HLA-DQA1, HLA-DRB1, HLA-C, TNFRSF1A
6extracellular spaceGO:0056158.1CCL2, TNFRSF1A, TNF, LTA, IL10
7integral to plasma membraneGO:0058877.6TNFRSF1A, TNF, HLA-C, HLA-DRB1, HLA-DQA1

Biological processes related to Sympathetic Ophthalmia according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1response to amino acid stimulusGO:0432009.9TNFRSF1A, CCL2
2cellular response to estradiol stimulusGO:0713929.8TNFRSF1A, IL10
3positive regulation of chronic inflammatory response to antigenic stimulusGO:0028769.7LTA, TNF
4positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.6LTA, TNF
5negative regulation of interferon-gamma productionGO:0326899.5IL10, HLA-DRB1
6positive regulation of synaptic transmissionGO:0508069.5TNF, CCL2
7receptor biosynthetic processGO:0328009.4TNF, IL10
8negative regulation of cytokine secretion involved in immune responseGO:0027409.4TNF, IL10
9interferon-gamma-mediated signaling pathwayGO:0603339.3HLA-DQA1, HLA-DRB1, HLA-C
10lipopolysaccharide-mediated signaling pathwayGO:0316639.3CCL2, TNF
11extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.3TNFRSF1A, TNF
12positive regulation of cytokine secretionGO:0507159.2IL10, TNF
13protein kinase B signaling cascadeGO:0434919.2TNF, CCL2
14humoral immune responseGO:0069599.2LTA, TNF, CCL2
15negative regulation of T cell proliferationGO:0421309.2IL10, HLA-DRB1
16negative regulation of growth of symbiont in hostGO:0441309.2IL10, LTA, TNF
17negative regulation of interleukin-6 productionGO:0327159.1IL10, TNF, TNFRSF1A
18negative regulation of gene expressionGO:0106299.1CRYAA, TNF, TNFRSF1A
19response to activityGO:0148239.1CCL2, TNF, IL10
20cellular response to organic cyclic compoundGO:0714078.9TNF, CCL2
21inflammatory responseGO:0069548.6CCL2, TNFRSF1A, TNF, IL10
22cytokine-mediated signaling pathwayGO:0192218.6CCL2, TNFRSF1A, HLA-C, HLA-DRB1, HLA-DQA1
23response to glucocorticoid stimulusGO:0513848.6IL10, CRYAA, TNF, CCL2
24response to hypoxiaGO:0016668.4LTA, CRYAA, TNF, TNFRSF1A, CCL2
25response to drugGO:0424938.2CCL2, TNF, CRYAA, LTA, IL10

Molecular functions related to Sympathetic Ophthalmia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.5HLA-DQA1, HLA-DRB1
2peptide antigen bindingGO:0426059.4HLA-DRB1, HLA-C
3tumor necrosis factor receptor bindingGO:0051649.0LTA, TNF
4cytokine activityGO:0051258.7IL10, LTA, TNF

Products for genes affiliated with Sympathetic Ophthalmia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sympathetic Ophthalmia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet