MCID: SYM002
MIFTS: 40

Sympathetic Ophthalmia malady

Categories: Eye diseases, Rare diseases, Immune diseases

Aliases & Classifications for Sympathetic Ophthalmia

Aliases & Descriptions for Sympathetic Ophthalmia:

Name: Sympathetic Ophthalmia 12 56 14
Ophthalmia, Sympathetic 42 69
Sympathetic Uveitis 12 56

Characteristics:

Orphanet epidemiological data:

56
sympathetic ophthalmia
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:12029
ICD10 33 H44.13
ICD9CM 35 360.11
MeSH 42 D009879
SNOMED-CT 64 75315001
Orphanet 56 ORPHA79098
MESH via Orphanet 43 D009879
UMLS via Orphanet 70 C0029077
ICD10 via Orphanet 34 H44.1
UMLS 69 C0029077

Summaries for Sympathetic Ophthalmia

MalaCards based summary : Sympathetic Ophthalmia, also known as ophthalmia, sympathetic, is related to chorioretinitis and retinitis. An important gene associated with Sympathetic Ophthalmia is CRYAA (Crystallin Alpha A), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Triamcinolone and triamcinolone acetonide have been mentioned in the context of this disorder. Affiliated tissues include eye and retina.

Wikipedia : 71 Sympathetic ophthalmia (SO) or Sympathetic uveitis is a bilateral diffuse granulomatous uveitis (a kind... more...

Related Diseases for Sympathetic Ophthalmia

Diseases related to Sympathetic Ophthalmia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
id Related Disease Score Top Affiliating Genes
1 chorioretinitis 29.8 CTLA4 HLA-DRB1 TNF
2 retinitis 10.3
3 choroiditis 10.3
4 spondylometaphyseal dysplasia east-african type 10.2 LTA TNF
5 thymic neuroendocrine carcinoma 10.2 LTA TNF
6 drug dependence 10.2 LTA TNF
7 idiopathic hypertrophic pachymeningitis 10.2 LTA TNF
8 vestibule of mouth cancer 10.2 LTA TNF
9 mirizzi syndrome 10.2 HLA-DRB1 TNF
10 distal trisomy 14q 10.2 HLA-DRB1 TNF
11 swine influenza 10.2 HLA-DRB1 TNF
12 cauda equina syndrome 10.2 LTA TNF
13 human immunodeficiency virus infectious disease 10.2 HLA-DRB1 TNF
14 childhood pleomorphic rhabdomyosarcoma 10.2 LTA TNF
15 endophthalmitis 10.2
16 primary ciliary dyskinesia 10.2 LTA TNF
17 clostridium difficile colitis 10.2 HLA-DRB1 TNF
18 right ventricle hypoplasia 10.2 HLA-DRB1 TNF
19 nystagmus, congenital motor, autosomal recessive 10.2 HLA-DRB1 TNF
20 aseptic meningitis 10.2 HLA-DRB1 TNF
21 pancreatic signet ring cell adenocarcinoma 10.2 HLA-DRB1 TNF
22 orthostatic proteinuria 10.2 LTA TNF
23 cryptococcosis 10.2 HLA-DRB1 TNF
24 chronic apical periodontitis 10.2 HLA-C TNF
25 congenital hypomyelination neuropathy 10.2 ITGA4 LTA
26 retinal detachment 10.2
27 cataract 10.2
28 hereditary alpha tryptasemia syndrome 10.2 HLA-DRB1 TNF
29 benign deep fibrous histiocytoma 10.2 HLA-DRB1 TNF
30 cerebellar liponeurocytoma 10.2 ITGA4 TNF
31 motility-related diarrhea 10.2 HLA-DRB1 TNF
32 learning disability 10.1 HLA-C HLA-DRB1
33 endogenous depression 10.1 HLA-DRB1 TNF
34 penis agenesis 10.1 HLA-DRB1 ITGA4
35 plummer's disease 10.1 HLA-DRB1 TNF
36 celiac disease 3 10.1 CTLA4 HLA-DRB1
37 complement component 8 deficiency 10.1 CTLA4 HLA-DRB1
38 pseudohypoparathyroidism 10.1 HLA-C HLA-DRB1
39 patau syndrome 10.1 HLA-DRB1 TNF
40 vogt-koyanagi-harada disease 10.1
41 melanoma 10.1
42 anaerobic meningitis 10.1 HLA-C HLA-DRB1
43 disease of mental health 10.1 HLA-DRB1 TNF
44 orbital osteomyelitis 10.1 HLA-C TNF
45 abnormal retinal correspondence 10.1 CTLA4 TNF
46 pulmonary hemosiderosis 10.1 HLA-DRB1 LTA TNF
47 deafness, autosomal recessive 67 10.1 HLA-DRB1 LTA TNF
48 atrial septal defect 6 10.1 HLA-DRB1 LTA TNF
49 adnp syndrome 10.1 LTA TNF
50 immunoglobulin g deficiency 10.0 HLA-DRB1 TNF

Graphical network of the top 20 diseases related to Sympathetic Ophthalmia:



Diseases related to Sympathetic Ophthalmia

Symptoms & Phenotypes for Sympathetic Ophthalmia

Drugs & Therapeutics for Sympathetic Ophthalmia

Drugs for Sympathetic Ophthalmia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 1, Phase 2 124-94-7 31307
2 triamcinolone acetonide Phase 1, Phase 2
3 glucocorticoids Phase 1, Phase 2
4 Hormone Antagonists Phase 1, Phase 2
5 Triamcinolone diacetate Phase 1, Phase 2
6 Triamcinolone hexacetonide Phase 1, Phase 2
7 Hormones Phase 1, Phase 2
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
9 Immunosuppressive Agents Phase 1, Phase 2
10 Anti-Inflammatory Agents Phase 1, Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Safety Study of Conventional Versus Micropulse Transscleral Cyclophotocoagulation in Treating End-Stage Glaucoma Unknown status NCT00349414 Phase 1, Phase 2
2 Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis Completed NCT01789320 Phase 1, Phase 2
3 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2
4 Adjunctive Photodynamic Therapy + Aflibercept vs. Afilbercept Alone for PDA in NV AMD Withdrawn NCT02457026

Search NIH Clinical Center for Sympathetic Ophthalmia

Cochrane evidence based reviews: ophthalmia, sympathetic

Genetic Tests for Sympathetic Ophthalmia

Anatomical Context for Sympathetic Ophthalmia

MalaCards organs/tissues related to Sympathetic Ophthalmia:

39
Eye, Retina

Publications for Sympathetic Ophthalmia

Articles related to Sympathetic Ophthalmia:

(show top 50) (show all 320)
id Title Authors Year
1
A rare case of atypical sympathetic ophthalmia post therapeutic keratoplasty. ( 27638462 )
2016
2
Multimodal Imaging in Sympathetic Ophthalmia. ( 27960610 )
2016
3
Long-Term Drug-Free Remission and Visual Outcomes in Sympathetic Ophthalmia. ( 26808121 )
2016
4
Sympathetic ophthalmia following a conjunctival flap procedure for corneal perforation. ( 26976837 )
2016
5
AN ATYPICAL CASE OF SYMPATHETIC OPHTHALMIA AFTER LIMBAL CORNEAL LACERATION. ( 27124790 )
2016
6
Characteristics of Sympathetic Ophthalmia in a Single International Center. ( 27651849 )
2016
7
Sympathetic Ophthalmia after Ocular Wasp Sting. ( 26635462 )
2015
8
SYMPATHETIC OPHTHALMIA: Clinicopathologic Correlation in a Consecutive Case Series. ( 25719985 )
2015
9
Enhanced depth imaging OCT (EDI-OCT) findings in acute phase of sympathetic ophthalmia. ( 25772275 )
2015
10
Bilateral hearing impairment as the initial symptom of sympathetic ophthalmia. ( 25720920 )
2015
11
A case of sympathetic ophthalmia after 23-gauge transconjunctival sutureless vitrectomy. ( 26028951 )
2015
12
Sympathetic ophthalmia caused by a severe ocular chemical burn: a case report and literature review. ( 25932266 )
2015
13
Spontaneous dislocation of a fluocinolone acetonide implant (retisert) into the anterior chamber and its successful extraction in sympathetic ophthalmia. ( 25411930 )
2015
14
Spectral-Domain Optical Coherence Tomography of Sympathetic Ophthalmia With Dalen-Fuchs Nodules. ( 25347826 )
2014
15
Sympathetic ophthalmia after diode laser cyclophotocoagulation: now an issue in informed consent. ( 25103662 )
2014
16
Sympathetic ophthalmia following diode laser cyclophotocoagulation. ( 24711656 )
2014
17
Gender differences in vogt-koyanagi-harada disease and sympathetic ophthalmia. ( 24734166 )
2014
18
Multiple serous retinal detachments seen on wide-field imaging in a patient with sympathetic ophthalmia. ( 25171189 )
2014
19
Classical pathology of sympathetic ophthalmia presented in a unique case. ( 25067979 )
2014
20
Long-term, drug-free remission of sympathetic ophthalmia with high-dose, short-term chlorambucil therapy. ( 24572676 )
2014
21
Adalimumab for pediatric sympathetic ophthalmia. ( 25010359 )
2014
22
Incidence of hypotony and sympathetic ophthalmia following trans-scleral cyclophotocoagulation for glaucoma and a report of risk factors. ( 23433313 )
2013
23
Sympathetic Ophthalmia in Pediatric Age Group: Clinical Features and Challenges in Management in a Tertiary Center in Southern India. ( 24131076 )
2013
24
Reversible alopecia in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia. ( 23514340 )
2013
25
High definition spectral domain optical coherence tomography of retinal pigment epithelial rip in a case of sympathetic ophthalmia. ( 23514588 )
2013
26
Sympathetic ophthalmia with sensorineural deafness - report of a case. ( 24225003 )
2013
27
Sympathetic ophthalmia following enucleation. ( 22124788 )
2013
28
Presumed sympathetic ophthalmia after scleral buckling surgery. ( 25383825 )
2013
29
Sympathetic ophthalmia: to the twenty-first century and beyond. ( 23724856 )
2013
30
Continued vision loss from progressive expansion of inactive chorioretinal scars in a myopic patient with well-controlled sympathetic ophthalmia. ( 25389936 )
2012
31
Expression of I+-crystallin in the retina of human sympathetic ophthalmia. ( 22052021 )
2012
32
Mitochondrial oxidative stress initiates visual loss in sympathetic ophthalmia. ( 22476625 )
2012
33
Update on sympathetic ophthalmia. ( 22346110 )
2012
34
Sympathetic ophthalmia: a review of literature. ( 22677732 )
2012
35
Sympathetic ophthalmia in HIV infection. A clinicopathological case report. ( 22411458 )
2012
36
Missed perforation presenting as sympathetic ophthalmia in an adolescent Malay girl. ( 22914237 )
2012
37
Immunopathologic processes in sympathetic ophthalmia as signified by microRNA profiling. ( 22589448 )
2012
38
Sympathetic ophthalmia after proton beam irradiation for choroA^dal melanoma. ( 22646709 )
2012
39
Presumed occult globe rupture resulting in sympathetic ophthalmia. ( 22200914 )
2012
40
Imaging for sympathetic ophthalmia: impact on the diagnosis and management. ( 22954939 )
2012
41
Multimodality diagnostic imaging in a case of sympathetic ophthalmia. ( 22594960 )
2012
42
Sympathetic ophthalmia. ( 21958181 )
2011
43
Sympathetic ophthalmia: enucleation or evisceration? ( 21876595 )
2011
44
A case of sympathetic ophthalmia after a severe acanthamoeba keratitis. ( 21471815 )
2011
45
Reversible retinal changes in the acute stage of sympathetic ophthalmia seen on spectral domain optical coherence tomography. ( 21331811 )
2011
46
Management and clinical outcome of penetrating keratoplasty for long-term corneal changes in sympathetic ophthalmia. ( 21772984 )
2011
47
Efficacy of infliximab therapy in two patients with sympathetic ophthalmia. ( 21484652 )
2011
48
Challenges of managing sympathetic ophthalmia in a young child and the role of infliximab. ( 21732578 )
2011
49
Successful treatment of refractory sympathetic ophthalmia in a child with infliximab. ( 21320978 )
2011
50
Sympathetic ophthalmia in an infected post-scleral buckling eye. ( 21603735 )
2011

Variations for Sympathetic Ophthalmia

Expression for Sympathetic Ophthalmia

Search GEO for disease gene expression data for Sympathetic Ophthalmia.

Pathways for Sympathetic Ophthalmia

Pathways related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 26)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 ITGA4 LTA
2
Show member pathways
13.16 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 ITGA4
3
Show member pathways
13.06 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF
4
Show member pathways
12.72 HLA-C HLA-DQA1 HLA-DRB1 ITGA4
5
Show member pathways
12.49 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF
6
Show member pathways
12.34 HLA-DQA1 HLA-DRB1 TNF
7
Show member pathways
12.27 HLA-C HLA-DQA1 HLA-DRB1
8
Show member pathways
12.15 CTLA4 HLA-DQA1 HLA-DRB1
9 12.06 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF
10 12.05 HLA-C HLA-DQA1 HLA-DRB1
11
Show member pathways
12.01 HLA-DQA1 HLA-DRB1 ITGA4 TNF
12 11.97 HLA-DQA1 HLA-DRB1 TNF
13
Show member pathways
11.94 CTLA4 HLA-DQA1 HLA-DRB1
14
Show member pathways
11.91 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 ITGA4 LTA
15
Show member pathways
11.88 HLA-C LTA TNF
16 11.87 HLA-C HLA-DQA1 HLA-DRB1
17 11.66 HLA-DQA1 HLA-DRB1 ITGA4 TNF
18 11.58 CTLA4 HLA-DQA1 HLA-DRB1 TNF
19 11.56 ITGA4 LTA TNF
20 11.52 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 ITGA4
21 11.48 CTLA4 HLA-DQA1 HLA-DRB1
22 11.37 HLA-DQA1 HLA-DRB1
23 11.35 LTA TNF
24
Show member pathways
11.31 LTA TNF
25 11.3 CTLA4 ITGA4 LTA TNF
26 11.05 HLA-DRB1 TNF

GO Terms for Sympathetic Ophthalmia

Cellular components related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.95 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 ITGA4 LTA
2 cell surface GO:0009986 9.56 HLA-C HLA-DRB1 ITGA4 TNF
3 external side of plasma membrane GO:0009897 9.5 CTLA4 HLA-DRB1 TNF
4 transport vesicle membrane GO:0030658 9.43 HLA-DQA1 HLA-DRB1
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.37 HLA-DQA1 HLA-DRB1
6 MHC class II protein complex GO:0042613 9.16 HLA-DQA1 HLA-DRB1
7 ER to Golgi transport vesicle membrane GO:0012507 9.13 HLA-C HLA-DQA1 HLA-DRB1
8 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.8 HLA-C HLA-DQA1 HLA-DRB1

Biological processes related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.71 CTLA4 HLA-C HLA-DQA1 HLA-DRB1
2 positive regulation of apoptotic process GO:0043065 9.7 CTLA4 LTA TNF
3 humoral immune response GO:0006959 9.54 LTA TNF
4 T cell costimulation GO:0031295 9.54 CTLA4 HLA-DQA1 HLA-DRB1
5 positive regulation of interferon-gamma production GO:0032729 9.51 LTA TNF
6 interferon-gamma-mediated signaling pathway GO:0060333 9.5 HLA-C HLA-DQA1 HLA-DRB1
7 negative regulation of T cell proliferation GO:0042130 9.49 CTLA4 HLA-DRB1
8 negative regulation of growth of symbiont in host GO:0044130 9.48 LTA TNF
9 leukocyte tethering or rolling GO:0050901 9.46 ITGA4 TNF
10 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.43 HLA-DQA1 HLA-DRB1
11 antigen processing and presentation GO:0019882 9.33 HLA-C HLA-DQA1 HLA-DRB1
12 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.26 LTA TNF
13 immune response GO:0006955 9.1 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF
14 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 8.96 LTA TNF

Molecular functions related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 9.16 LTA TNF
2 MHC class II receptor activity GO:0032395 8.96 HLA-DQA1 HLA-DRB1
3 peptide antigen binding GO:0042605 8.8 HLA-C HLA-DQA1 HLA-DRB1

Sources for Sympathetic Ophthalmia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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