MCID: SYM002
MIFTS: 54

Sympathetic Ophthalmia malady

Eye diseases, Rare diseases, Immune diseases categories

Summaries for Sympathetic Ophthalmia

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Wikipedia:64 Sympathetic ophthalmia (SO) is a bilateral diffuse granulomatous uveitis (a kind of inflammation) of... more...

MalaCards based summary: Sympathetic Ophthalmia, also known as sympathetic uveitis, is related to behcet's disease and melanoma. An important gene associated with Sympathetic Ophthalmia is CRYAA (crystallin, alpha A), and among its related pathways are 14-3-3 and Regulation of BAD Activity and Canonical NF-kappaB pathway. The compounds dpa 1 and cdp571 have been mentioned in the context of this disorder. Affiliated tissues include eye and retina, and related mouse phenotypes are limbs/digits/tail and craniofacial.

Aliases & Classifications for Sympathetic Ophthalmia

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Sources:
9Disease Ontology, 48Orphanet, 61UMLS, 34MeSH, 28ICD9CM, 56SNOMED-CT, 35MESH via Orphanet, 27ICD10 via Orphanet, 62UMLS via Orphanet
See all sources

Sympathetic Ophthalmia, Aliases & Descriptions:

Name: Sympathetic Ophthalmia 9 48
Sympathetic Uveitis 9 48
 
Ophthalmia, Sympathetic 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases, Immune diseases
Orphanet: 48 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

48
sympathetic ophthalmia:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Variable


External Ids:

Disease Ontology9 DOID:12029
MeSH34 D009879
ICD9CM28 360.11
SNOMED-CT56 75315001
MESH via Orphanet35 D009879
ICD10 via Orphanet27 H44.1
UMLS via Orphanet62 C0029077

Related Diseases for Sympathetic Ophthalmia

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Diseases related to Sympathetic Ophthalmia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1behcet's disease30.4LTA, TNF, HLA-C
2melanoma30.0TYRP1, HLA-C, HLA-DRB1, TNF, IL10
3sarcoidosis29.7HLA-C, HLA-DRB1, TNF, CCL2, LTA
4uveitis29.3HLA-C, TNF, TNFRSF1A, CCL2, IL10, LTA
5retinitis10.7
6choroiditis10.7
7endophthalmitis10.6
8cataract10.6
9retinal detachment10.6
10vogt-koyanagi-harada disease10.5
11blindness10.4
12leprosy10.4HLA-DRB1
13blau syndrome10.4TNF
14periapical granuloma10.4CCL2
15neovascular glaucoma10.3
16chorioretinitis10.3
17keratitis10.3
18periodic fever, familial, autosomal dominant10.3TNF, TNFRSF1A
19psoriatic arthritis10.2TNF, HLA-C
20skin disease10.2HLA-DRB1
21familial mediterranean fever10.2TNFRSF1A, TNF
22extrinsic allergic alveolitis10.2TNFRSF1A, CCL2
23toxic shock syndrome10.2TNF, LTA
24arthritis10.2TNF, TNFRSF1A
25abdominal aortic aneurysm10.2CCL2, TNFRSF1A
26microphthalmia10.2CRYAA, TYRP1
27alopecia10.2
28panophthalmitis10.2
29conjunctival pigmentation10.2
30diphtheria10.2
31cerebritis10.2
32chorioretinal scar10.2
33hypopyon10.2
34purulent endophthalmitis10.2
35turner syndrome10.2
36vasculitis10.2
37acanthamoeba keratitis10.2
38adult respiratory distress syndrome10.2LTA, TNF
39alcoholic hepatitis10.2CCL2, TNF
40interstitial lung disease10.2CCL2, TNF
41selective iga deficiency disease10.1LTA, IL10
42lepromatous leprosy10.1LTA, IL10
43leishmaniasis10.1IL10, TNFRSF1A
44ankylosing spondylitis10.1TNF, TNFRSF1A
45visceral leishmaniasis10.1LTA, IL10
46thyroiditis10.1HLA-C, HLA-DRB1
47paracoccidioidomycosis10.1IL10, TNFRSF1A
48phacoanaphylactic uveitis10.1
49pulmonary sarcoidosis10.1LTA, CCL2, TNF
50common variable immunodeficiency10.1TNFRSF1A, IL10

Graphical network of the top 20 diseases related to Sympathetic Ophthalmia:



Diseases related to sympathetic ophthalmia

Symptoms for Sympathetic Ophthalmia

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Drugs & Therapeutics for Sympathetic Ophthalmia

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Drug clinical trials:

Search ClinicalTrials for Sympathetic Ophthalmia

Search NIH Clinical Center for Sympathetic Ophthalmia

Genetic Tests for Sympathetic Ophthalmia

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Anatomical Context for Sympathetic Ophthalmia

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MalaCards organs/tissues related to Sympathetic Ophthalmia:

32
Eye, Retina

Animal Models for Sympathetic Ophthalmia or affiliated genes

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Publications for Sympathetic Ophthalmia

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Articles related to Sympathetic Ophthalmia:

(show top 50)    (show all 304)
idTitleAuthorsYear
1
Presumed sympathetic ophthalmia after scleral buckling surgery. (25383825)
2013
2
Reversible retinal changes in the acute stage of sympathetic ophthalmia seen on spectral domain optical coherence tomography. (21331811)
2011
3
Sympathetic ophthalmia: enucleation or evisceration? (21876595)
2011
4
A case of sympathetic ophthalmia presenting with extraocular symptoms and conjunctival pigmentation after repeated 23-gauge vitrectomy. (20662657)
2010
5
Sympathetic ophthalmia following postoperative endophthalmitis and evisceration. (20596271)
2010
6
Periocular injections of triamcinolone for sympathetic ophthalmia. (20572826)
2010
7
Development of sympathetic ophthalmia following globe injury. (20137482)
2009
8
Subretinal hypopyon in sympathetic ophthalmia. (19412871)
2009
9
Intravitreal steroid slow-release device replacing repeated intravitreal triamcinolone injections for sympathetic ophthalmia. (18850570)
2008
10
Sympathetic ophthalmia in Singapore: new trends in an old disease. (16028023)
2006
11
Sympathetic ophthalmia following postoperative bacterial endophthalmitis: a clinicopathologic study. (16490496)
2006
12
Bilateral exudative retinal detachments as initial presentation of sympathetic ophthalmia in Turner syndrome. (16883368)
2006
13
Repeated intravitreal triamcinolone acetonide for chronic sympathetic ophthalmia. (16704716)
2006
14
Intravitreal triamcinolone acetonide in sympathetic ophthalmia. (15756580)
2005
15
Immunopathology of progressive subretinal fibrosis: a variant of sympathetic ophthalmia. (15364234)
2004
16
Sympathetic ophthalmia associated with ocular and cerebral vasculitis: an angiographic and radiologic study. (12948320)
2003
17
Incidence of sympathetic ophthalmia after penetrating eye injury and choice of treatment. (12789598)
2002
18
Sympathetic ophthalmia after three pars plana vitrectomies without prior ocular injury. (10950423)
2000
19
Sympathetic ophthalmia associated with antecedent adherent leucoma--a rare association. (9686861)
1998
20
Immunogenetic study of sympathetic ophthalmia. (9062965)
1997
21
Chlorambucil therapy in sympathetic ophthalmia. (7709973)
1995
22
Sympathetic ophthalmia. (10155637)
1994
23
Successfully treated sympathetic ophthalmia with typical histological confirmation. (8485440)
1993
24
Sympathetic ophthalmia after cyclocryotherapy of neovascular glaucoma without ocular penetration. (8446333)
1993
25
Surgical treatment of sympathetic ophthalmia. (1794786)
1991
26
A historical review of sympathetic ophthalmia and its epidemiology. (2678549)
1989
27
Sympathetic ophthalmia following neodymium:YAG cyclotherapy. (2779962)
1989
28
Delayed onset sympathetic ophthalmia. (3670198)
1987
29
Histologic and immunopathologic findings in sympathetic ophthalmia. (3994570)
1985
30
Sympathetic ophthalmia. (6479777)
1984
31
Effect of corticosteroid treatment and enucleation on the visual prognosis of sympathetic ophthalmia. (6614106)
1983
32
Recent advances in sympathetic ophthalmia. (396680)
1979
33
Sympathetic ophthalmia. A long-term follow-up. (629672)
1978
34
Sympathetic ophthalmia in Canada. (4274314)
1972
35
Sympathetic ophthalmia after couching operation. (4668490)
1972
36
Lymphocyte-stimulating activity of ocular tissues in sympathetic ophthalmia. (5124018)
1971
37
Observations on sympathetic ophthalmia. (5904961)
1966
38
Sympathetic Ophthalmia: A Case Treated by Prolonged Use of Corticotropin and Adrenal Steroids. (16693596)
1960
39
Sympathetic ophthalmia controlled by continuous cortisone therapy over a four-year period. (13458314)
1957
40
Sympathetic ophthalmia treated with cortisone. (14923790)
1952
41
Sympathizing eye in sympathetic ophthalmia; a pathologic study. (12984910)
1952
42
Sympathetic ophthalmia. (15412255)
1950
43
The important complications of cataract surgery exclusive of sympathetic ophthalmia. (15407741)
1949
44
Malignant melanoma of the choroid with sympathetic ophthalmia. (18132900)
1949
45
Sympathetic ophthalmia or phacoanaphylaxis? (18874349)
1948
46
Case of Sympathetic Ophthalmia. (18736629)
1915
47
NOTE ON THE BLOOD IN SYMPATHETIC OPHTHALMIA. (20765685)
1911
48
SYMPATHETIC OPHTHALMIA. (20757901)
1898
49
Sympathetic Ophthalmia: A Historical Correction. (20747958)
1875
50
Manchester Eye Hospital: Sympathetic Ophthalmia - Complete Loss of Vision-Restoration of Sight by Operative Means. (21373119)
1842

Variations for Sympathetic Ophthalmia

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Expression for genes affiliated with Sympathetic Ophthalmia

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Expression patterns in normal tissues for genes affiliated with Sympathetic Ophthalmia

Search GEO for disease gene expression data for Sympathetic Ophthalmia.

Pathways for genes affiliated with Sympathetic Ophthalmia

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Pathways related to Sympathetic Ophthalmia according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1TNFRSF1A
29.5TNFRSF1A, TNF
39.5TNFRSF1A, TNF
4
Show member pathways
9.5TNF, TNFRSF1A
59.5TNFRSF1A, TNF
69.5TNFRSF1A, TNF
7
Show member pathways
9.5HLA-DRB1, HLA-DQA1
89.4TNF, CCL2
99.3LTA, IL10
10
Show member pathways
9.2LTA, TNFRSF1A, TNF
11
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
9.2LTA, TNFRSF1A, TNF
12
Show member pathways
9.2TNF, TNFRSF1A, LTA
13
Show member pathways
9.2LTA, TNFRSF1A, TNF
14
Show member pathways
9.2TNF, TNFRSF1A, LTA
15
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
9.2LTA, TNFRSF1A, TNF
16
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway59
9.2LTA, TNFRSF1A, TNF
17
Show member pathways
9.2LTA, TNFRSF1A, TNF
189.2TNF, TNFRSF1A, LTA
19
Show member pathways
9.2LTA, TNFRSF1A, TNF
209.1TNF, IL10
219.1TNF, IL10
22
Show member pathways
9.0HLA-C, HLA-DQA1, HLA-DRB1
239.0HLA-C, HLA-DQA1, HLA-DRB1
249.0HLA-DRB1, HLA-DQA1, HLA-C
25
Show member pathways
9.0HLA-DRB1, HLA-DQA1, HLA-C
26
Show member pathways
IL27-mediated signaling events37
8.8LTA, IL10, TNF
278.8TNF, IL10, LTA
28
Show member pathways
8.7IL10, TNFRSF1A, TNF
298.7LTA, CCL2, TNFRSF1A, TNF
30
Show member pathways
Apoptosis and survival TNFR1 signaling pathway59
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
8.7LTA, CCL2, TNFRSF1A, TNF
318.7HLA-DQA1, HLA-DRB1, IL10
32
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
8.6TNF, CCL2, IL10
338.6TNF, CCL2, IL10
34
Show member pathways
8.5HLA-DQA1, HLA-DRB1, TNF, TNFRSF1A
358.5HLA-DRB1, TNF, IL10
368.4HLA-DQA1, HLA-DRB1, TNF, CCL2
37
Show member pathways
8.4HLA-C, HLA-DQA1, TNF, TNFRSF1A, LTA
388.2HLA-C, HLA-DQA1, HLA-DRB1, IL10
39
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.2IL10, CCL2, TNFRSF1A, TNF
40
Show member pathways
8.1HLA-DQA1, HLA-DRB1, TNF, IL10
41
Show member pathways
7.9TNF, TNFRSF1A, CCL2, IL10, LTA
42
Show member pathways
7.9TNF, TNFRSF1A, CCL2, IL10, LTA
43
Show member pathways
7.9TNF, TNFRSF1A, CCL2, IL10, LTA
44
Show member pathways
7.9TNF, TNFRSF1A, CCL2, IL10, LTA
45
Show member pathways
7.9TNF, TNFRSF1A, CCL2, IL10, LTA
467.7HLA-C, HLA-DQA1, HLA-DRB1, TNF, TNFRSF1A, LTA
47
Show member pathways
7.7IL10, TNFRSF1A, TNF, HLA-DRB1, HLA-DQA1
487.7HLA-DQA1, HLA-DRB1, TNF, TNFRSF1A, IL10
49
Show member pathways
7.2HLA-C, HLA-DQA1, HLA-DRB1, TNF, TNFRSF1A, CCL2
50
Show member pathways
6.9LTA, HLA-C, HLA-DQA1, HLA-DRB1, TNF, TNFRSF1A

Compounds for genes affiliated with Sympathetic Ophthalmia

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Compounds related to Sympathetic Ophthalmia according to GeneCards/GeneDecks:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1dpa 1449.7HLA-DRB1, HLA-DQA1
2cdp571449.2TNF, IL10
3cyclosporine50 1210.2LTA, IL10, TNF
4rantes449.2IL10, TNFRSF1A, CCL2
5blys449.1TNF, TNFRSF1A, IL10
6interferon gamma449.1IL10, TNF
7adalimumab44 50 1211.1TNF, TNFRSF1A, IL10
8mycophenolate mofetil44 50 1211.1IL10, LTA, TNF
9herbimycin a44 6010.1TNF, LTA, CCL2, TNFRSF1A
10fmlp449.1TNFRSF1A, LTA, CCL2, TNF
11pentoxifylline44 1210.0TNF, LTA, IL10
12mip 1alpha449.0TNF, CCL2, IL10
13il-12449.0IL10, CCL2, TNF
145 aminosalicylic acid449.0IL10, CCL2, TNF
15polymyxin b449.0TNF, IL10, CCL2
16groalpha449.0CCL2, TNF, IL10
17gm-csf44 2910.0CCL2, TNF, IL10
188-isoprostane448.9IL10, CCL2, TNF
19tarc448.9IL10, CCL2, TNF
20ccl344 299.9TNF, CCL2, IL10
21actinomycin d448.8LTA, TNFRSF1A, CCL2, TNF
22okt3448.8TNF, TNFRSF1A, IL10, LTA
23etanercept44 50 1210.8IL10, TNF, LTA, TNFRSF1A
24infliximab44 50 1210.8TNFRSF1A, TNF, IL10, LTA
25ivig448.8IL10, TNFRSF1A, LTA, TNF
26neopterin448.8TNF, TNFRSF1A, LTA, IL10
27thalidomide44 50 60 1211.8IL10, TNFRSF1A, TNF
2815-deoxy-delta-12,14-prostaglandin j2448.8IL10, CCL2, TNF
29ionomycin448.8TNF, TNFRSF1A, LTA, IL10
30chloroquine44 3 50 29 1212.7TNFRSF1A, IL10, TNF
31calcitriol44 60 25 1211.7TNF, TNFRSF1A, IL10, LTA
32toxin-1448.7TNF, IL10, CCL2, LTA
33lipoteichoic acid448.7TNF, CCL2, IL10, LTA
34il 10448.7LTA, TNF, CCL2, IL10
35simvastatin44 50 60 29 25 1213.6CCL2, TNFRSF1A, TNF, IL10
36prostacyclin448.6TNFRSF1A, TNF, CCL2, IL10
37sb 20358044 609.5TNFRSF1A, CCL2, TNF, IL10
38aspartate448.4IL10, HLA-DQA1, CRYAA, CCL2, TNFRSF1A
39methotrexate50 44 1210.4IL10, HLA-DRB1, TNFRSF1A, TNF
40paraffin448.4TNFRSF1A, HLA-DQA1, LTA, CCL2, IL10
41tgf beta1448.3CCL2, LTA, TNF, IL10, TNFRSF1A
42endotoxin448.3CCL2, TNFRSF1A, TNF, LTA, IL10
43pge2448.3TNF, TNFRSF1A, CCL2, IL10, LTA
44oxygen44 259.3CCL2, TNFRSF1A, TNF, TYRP1, LTA
45serine448.3LTA, TNF, TYRP1, CCL2, TNFRSF1A, CRYAA
46cycloheximide448.2TNF, LTA, IL10, TNFRSF1A, CCL2
47dexamethasone44 50 29 1211.2CCL2, TNFRSF1A, TNF, LTA, IL10
48vegf448.1TNF, TNFRSF1A, CCL2, IL10, LTA
49nitric oxide44 25 1210.1IL10, LTA, TNF, TNFRSF1A, CCL2
50cyclosporin a44 29 6010.1IL10, TNF, LTA, TNFRSF1A

GO Terms for genes affiliated with Sympathetic Ophthalmia

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Cellular components related to Sympathetic Ophthalmia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.5HLA-DRB1, HLA-DQA1
2transport vesicle membraneGO:0306589.5HLA-DQA1, HLA-DRB1
3endocytic vesicle membraneGO:0306669.5HLA-DRB1, HLA-DQA1
4clathrin-coated endocytic vesicle membraneGO:0306699.4HLA-DRB1, HLA-DQA1, TYRP1
5trans-Golgi network membraneGO:0325889.4HLA-DRB1, HLA-DQA1
6integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.3HLA-DRB1, HLA-DQA1, HLA-C
7ER to Golgi transport vesicle membraneGO:0125079.2HLA-C, HLA-DQA1, HLA-DRB1
8cell surfaceGO:0099868.8TNFRSF1A, TNF, HLA-C
9Golgi membraneGO:0001398.7TNFRSF1A, HLA-DRB1, HLA-DQA1, HLA-C
10integral component of plasma membraneGO:0058878.2HLA-C, HLA-DQA1, HLA-DRB1, TNF, TNFRSF1A
11extracellular spaceGO:0056158.0LTA, IL10, CCL2, TNFRSF1A, TNF

Biological processes related to Sympathetic Ophthalmia according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.0LTA, TNF
2positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.9LTA, TNF
3response to amino acidGO:0432009.8CCL2, TNFRSF1A
4positive regulation of synaptic transmissionGO:0508069.7TNF, CCL2
5defense response to Gram-positive bacteriumGO:0508309.7TNF, LTA
6lipopolysaccharide-mediated signaling pathwayGO:0316639.7TNF, CCL2
7extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.6TNF, TNFRSF1A
8protein kinase B signalingGO:0434919.6CCL2, TNF
9positive regulation of interferon-gamma productionGO:0327299.6LTA, TNF
10cellular response to organic cyclic compoundGO:0714079.6TNF, CCL2
11negative regulation of gene expressionGO:0106299.6CRYAA, TNFRSF1A, TNF
12cellular response to estradiol stimulusGO:0713929.5IL10, TNFRSF1A
13receptor biosynthetic processGO:0328009.5TNF, IL10
14negative regulation of cytokine secretion involved in immune responseGO:0027409.4TNF, IL10
15response to mechanical stimulusGO:0096129.4CCL2, TNF
16humoral immune responseGO:0069599.4LTA, CCL2, TNF
17positive regulation of cytokine secretionGO:0507159.4TNF, IL10
18interferon-gamma-mediated signaling pathwayGO:0603339.4HLA-DRB1, HLA-DQA1, HLA-C
19negative regulation of interferon-gamma productionGO:0326899.3HLA-DRB1, IL10
20intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.2TNFRSF1A, TNF
21negative regulation of T cell proliferationGO:0421309.2IL10, HLA-DRB1
22negative regulation of growth of symbiont in hostGO:0441309.2TNF, IL10, LTA
23negative regulation of interleukin-6 productionGO:0327159.1IL10, TNFRSF1A, TNF
24response to activityGO:0148239.0TNF, CCL2, IL10
25immune responseGO:0069558.9HLA-C, HLA-DQA1, HLA-DRB1
26response to hypoxiaGO:0016668.8LTA, CRYAA, CCL2, TNFRSF1A, TNF
27response to glucocorticoidGO:0513848.7TNF, CCL2, IL10, CRYAA
28inflammatory responseGO:0069548.5TNF, TNFRSF1A, CCL2, IL10
29cytokine-mediated signaling pathwayGO:0192218.5HLA-C, HLA-DQA1, HLA-DRB1, TNFRSF1A, CCL2
30response to drugGO:0424938.3LTA, CRYAA, IL10, CCL2, TNF

Molecular functions related to Sympathetic Ophthalmia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.5HLA-DRB1, HLA-DQA1
2tumor necrosis factor receptor bindingGO:0051649.5TNF, LTA
3receptor bindingGO:0051029.2LTA, CCL2, HLA-C
4peptide antigen bindingGO:0426059.1HLA-DRB1, HLA-C
5cytokine activityGO:0051258.8LTA, IL10, TNF

Products for genes affiliated with Sympathetic Ophthalmia

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Sources for Sympathetic Ophthalmia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet