MCID: SYM002
MIFTS: 34

Sympathetic Ophthalmia malady

Eye diseases, Rare diseases, Immune diseases categories

Aliases & Classifications for Sympathetic Ophthalmia

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Sources:
10Disease Ontology, 12DISEASES, 51Orphanet, 65UMLS, 36MeSH, 29ICD9CM, 59SNOMED-CT, 37MESH via Orphanet, 66UMLS via Orphanet, 28ICD10 via Orphanet
See all sources

Aliases & Descriptions for Sympathetic Ophthalmia:

Name: Sympathetic Ophthalmia 10 12 51
Ophthalmia, Sympathetic 65 36
 
Sympathetic Uveitis 10 51


Classifications:

Orphanet: 51 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

51
sympathetic ophthalmia:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Disease Ontology10 DOID:12029
ICD9CM29 360.11
MeSH36 D009879
Orphanet51 79098
SNOMED-CT59 75315001
MESH via Orphanet37 D009879
UMLS via Orphanet66 C0029077
ICD10 via Orphanet28 H44.1

Summaries for Sympathetic Ophthalmia

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Wikipedia:68 Sympathetic ophthalmia (SO) is a bilateral diffuse granulomatous uveitis (a kind of inflammation) of... more...

MalaCards based summary: Sympathetic Ophthalmia, also known as ophthalmia, sympathetic, is related to choroiditis and retinitis. An important gene associated with Sympathetic Ophthalmia is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways are Transcription_NF-kB signaling pathway and Cellular Transformation by HTLV1. Affiliated tissues include eye and retina.

Related Diseases for Sympathetic Ophthalmia

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Diseases related to Sympathetic Ophthalmia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1choroiditis10.7
2retinitis10.7
3endophthalmitis10.7
4retinal detachment10.6
5cataract10.6
6vogt-koyanagi-harada disease10.6
7melanoma10.6
8keratitis10.4
9neovascular glaucoma10.4
10chorioretinitis10.4
11alopecia10.2
12behcet's disease10.2
13panophthalmitis10.2
14diphtheria10.2
15cerebritis10.2
16chorioretinal scar10.2
17hypopyon10.2
18purulent endophthalmitis10.2
19turner syndrome10.2
20uveitis10.2
21vasculitis10.2
22acanthamoeba keratitis10.2
23tucker syndrome10.1HLA-DQA1, HLA-DRB1
24testicular monophasic choriocarcinoma10.1HLA-DQA1, HLA-DRB1
25senile angioma10.1HLA-DRB1, TNFRSF1A
26acute endometritis10.1HLA-DQA1, HLA-DRB1
27paronychia10.1CRYAA, TNFRSF1A
28hordeolum10.1HLA-DQA1, HLA-DRB1
29precursor b lymphoblastic lymphoma/leukemia10.1LTA, TNFRSF1A
30oculogyric crisis10.1HLA-DQA1, HLA-DRB1
31phacoanaphylactic uveitis10.1
32childhood cerebellar astrocytic neoplasm10.1HLA-C, HLA-DRB1
33intermediate anorectal malformation10.1HLA-DQA1, LTA
34optic papillitis10.1HLA-DRB1, LTA
35ichthyosis - hypotrichosis - sclerosing cholangitis10.0HLA-C, HLA-DRB1
36small intestinal sarcoma10.0HLA-DQA1, HLA-DRB1
37autoimmune polyglandular syndrome type 210.0CTLA4, HLA-DRB1
38orbital osteomyelitis10.0HLA-C, LTA
39moderately severe hemophilia a10.0CTLA4, HLA-DRB1
40homozygous familial hypercholesterolemia10.0CTLA4, HLA-DQA1
41sarcoidosis 110.0HLA-DRB1, LTA
42lens disease10.0HLA-DQA1, HLA-DRB1
43acute porphyria10.0CTLA4, LTA
44chronic adhesive otitis media9.9CTLA4, LTA
45tularemia9.9HLA-DQA1, HLA-DRB1, TNFRSF1A
46autoimmune disease of gastrointestinal tract9.9CTLA4, HLA-DRB1
47chronic inflammatory demyelinating polyradiculoneuropathy9.9HLA-DQA1, HLA-DRB1, LTA
48spondyloarthropathy9.9HLA-C, LTA
49prostate stromal sarcoma9.9CTLA4, HLA-DRB1
50pulmonary nodular lymphoid hyperplasia9.9HLA-C, HLA-DQA1, HLA-DRB1

Graphical network of the top 20 diseases related to Sympathetic Ophthalmia:



Diseases related to sympathetic ophthalmia

Symptoms for Sympathetic Ophthalmia

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Drugs & Therapeutics for Sympathetic Ophthalmia

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Drugs for Sympathetic Ophthalmia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
TriamcinoloneapprovedPhase 1, Phase 2429124-94-731307
Synonyms:
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione
11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11beta,16alpha,17alpha,21-Tetrahydroxy-9alpha-fluoro-1,4-pregnadiene-3,20-dione
124-94-7
4-08-00-03629 (Beilstein Handbook Reference)
83474-03-7
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-16-alpha-hydroxyprednisolone
9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy
9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-hydroxyprednisolone
9α-fluoro-16α-hydroxyprednisolone
AC-2072
AC1L1LDH
AC1Q5HJC
Adcortyl
Allernaze
Aristocort
Aristocort A
Aristocort Tablets
Aristogel
Aristospan
Azmacort
BPBio1_000154
BRD-K77554836-001-03-3
BRN 2341955
BSPBio_000140
Bio-0662
C21H27FO6
CHEMBL1451
CID31307
CL 19823
Celeste
Cinolone
Cinolone-T
D00385
D014221
DB00620
Delphicort
EINECS 204-718-7
EU-0101179
Fluoxiprednisolone
Fluoxyprednisolone
Flutex
Fougera
HMS1568G22
HMS2090D12
HSDB 3194
Kenacort
Kenacort (TN)
Kenacort-A
Kenacort-AG
Kenacort-Ag
Kenalog
Kenalog in Orabase
Kenalog-10
Kenalog-40
Kenalog-H
LS-698
Ledercort
Lopac0_001179
MLS000028542
MLS001066543
 
MLS002695935
MolPort-002-528-981
Mycolog
NCGC00021580-03
NCGC00021580-04
NCGC00021580-05
NCGC00021580-06
NCGC00021580-07
NCI60_000750
NSC 13397
NSC13397
Nasacort
Nasacort Aq
Nasacort Hfa
Omcilon
Omicilon
Oracort
Oralone
Orion
Polcortolon
Pregna-1,4-diene-3,20-dio
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)
Prestwick0_000120
Prestwick1_000120
Prestwick2_000120
Prestwick3_000120
Prestwick_438
Rodinolone
S1933_Selleck
SK-Triamcinolone
SMP1_000300
SMR000058333
SPBio_002079
Sk-Triamcinolone
T6376_SIGMA
TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))
Tiamcinolonum
Tiamcinolonum [INN-Latin]
Tri-Nasal
Triacet
Triacort
Triam-Tablinen
Triamcet
Triamcinalone
Triamcinlon
Triamcinolon
Triamcinolona
Triamcinolona [INN-Spanish]
Triamcinolone (JP15/USP/INN)
Triamcinolone Acetonide
Triamcinolone [USAN:INN:BAN:JAN]
Triamcinolone acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Triamcinolonum
Triamcinolonum [INN]
Trianex
Triatex
Tricortale
Triderm
Triesence
Trilone
Tristoject
Trymex
UNII-1ZK20VI6TY
Vetalog
Volon
Volon A
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ
ZINC03882036
droxypregna-1,4-diene-3,20-dione
ione
nchembio.2007.53-comp7
triamcinolone
2Triamcinolone hexacetonidePhase 1, Phase 2429
3Triamcinolone diacetatePhase 1, Phase 2429
4triamcinolone acetonidePhase 1, Phase 2429
5
Verteporfinapproved, investigational82129497-78-55362420
Synonyms:
Verteporfin
Verteporfina
 
Verteporfinum
Vertéporfine
Visudyne

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat UveitisCompletedNCT01789320Phase 1, Phase 2
2Safety and Efficacy of AIN457 in Noninfectious UveitisCompletedNCT00685399Phase 2
3Safety Study of Conventional Versus Micropulse Transscleral Cyclophotocoagulation in Treating End-Stage GlaucomaRecruitingNCT00349414Phase 1, Phase 2
4Adjunctive Photodynamic Therapy + Aflibercept vs. Afilbercept Alone for PDA in NV AMDNot yet recruitingNCT02457026

Search NIH Clinical Center for Sympathetic Ophthalmia


Cochrane evidence based reviews: Ophthalmia, Sympathetic

Genetic Tests for Sympathetic Ophthalmia

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Anatomical Context for Sympathetic Ophthalmia

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MalaCards organs/tissues related to Sympathetic Ophthalmia:

33
Eye, Retina

Animal Models for Sympathetic Ophthalmia or affiliated genes

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Publications for Sympathetic Ophthalmia

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Articles related to Sympathetic Ophthalmia:

(show top 50)    (show all 305)
idTitleAuthorsYear
1
Bilateral hearing impairment as the initial symptom of sympathetic ophthalmia. (25720920)
2015
2
Presumed sympathetic ophthalmia after scleral buckling surgery. (25383825)
2013
3
Reversible retinal changes in the acute stage of sympathetic ophthalmia seen on spectral domain optical coherence tomography. (21331811)
2011
4
Sympathetic ophthalmia: enucleation or evisceration? (21876595)
2011
5
Sympathetic ophthalmia following postoperative endophthalmitis and evisceration. (20596271)
2010
6
Periocular injections of triamcinolone for sympathetic ophthalmia. (20572826)
2010
7
Development of sympathetic ophthalmia following globe injury. (20137482)
2009
8
Subretinal hypopyon in sympathetic ophthalmia. (19412871)
2009
9
Management of sympathetic ophthalmia with the fluocinolone acetonide implant. (19147232)
2009
10
Intravitreal steroid slow-release device replacing repeated intravitreal triamcinolone injections for sympathetic ophthalmia. (18850570)
2008
11
Sympathetic ophthalmia in Singapore: new trends in an old disease. (16028023)
2006
12
Sympathetic ophthalmia following postoperative bacterial endophthalmitis: a clinicopathologic study. (16490496)
2006
13
Bilateral exudative retinal detachments as initial presentation of sympathetic ophthalmia in Turner syndrome. (16883368)
2006
14
Repeated intravitreal triamcinolone acetonide for chronic sympathetic ophthalmia. (16704716)
2006
15
Intravitreal triamcinolone acetonide in sympathetic ophthalmia. (15756580)
2005
16
Immunopathology of progressive subretinal fibrosis: a variant of sympathetic ophthalmia. (15364234)
2004
17
Sympathetic ophthalmia associated with ocular and cerebral vasculitis: an angiographic and radiologic study. (12948320)
2003
18
Incidence of sympathetic ophthalmia after penetrating eye injury and choice of treatment. (12789598)
2002
19
Sympathetic ophthalmia after three pars plana vitrectomies without prior ocular injury. (10950423)
2000
20
Sympathetic ophthalmia associated with antecedent adherent leucoma--a rare association. (9686861)
1998
21
Immunogenetic study of sympathetic ophthalmia. (9062965)
1997
22
Chlorambucil therapy in sympathetic ophthalmia. (7709973)
1995
23
Sympathetic ophthalmia. (10155637)
1994
24
Successfully treated sympathetic ophthalmia with typical histological confirmation. (8485440)
1993
25
Sympathetic ophthalmia after cyclocryotherapy of neovascular glaucoma without ocular penetration. (8446333)
1993
26
Surgical treatment of sympathetic ophthalmia. (1794786)
1991
27
A historical review of sympathetic ophthalmia and its epidemiology. (2678549)
1989
28
Sympathetic ophthalmia following neodymium:YAG cyclotherapy. (2779962)
1989
29
Delayed onset sympathetic ophthalmia. (3670198)
1987
30
Histologic and immunopathologic findings in sympathetic ophthalmia. (3994570)
1985
31
Sympathetic ophthalmia. (6479777)
1984
32
Effect of corticosteroid treatment and enucleation on the visual prognosis of sympathetic ophthalmia. (6614106)
1983
33
Pigmentation associated histopathological variations in sympathetic ophthalmia. (7387955)
1980
34
Recent advances in sympathetic ophthalmia. (396680)
1979
35
Sympathetic ophthalmia. A long-term follow-up. (629672)
1978
36
Sympathetic ophthalmia in Canada. (4274314)
1972
37
Sympathetic ophthalmia after couching operation. (4668490)
1972
38
Lymphocyte-stimulating activity of ocular tissues in sympathetic ophthalmia. (5124018)
1971
39
Observations on sympathetic ophthalmia. (5904961)
1966
40
Sympathetic ophthalmia controlled by continuous cortisone therapy over a four-year period. (13458314)
1957
41
Sympathetic ophthalmia treated with cortisone. (14923790)
1952
42
Sympathizing eye in sympathetic ophthalmia; a pathologic study. (12984910)
1952
43
Sympathetic ophthalmia. (15412255)
1950
44
Malignant melanoma of the choroid with sympathetic ophthalmia. (18132900)
1949
45
Sympathetic ophthalmia or phacoanaphylaxis? (18874349)
1948
46
Case of Sympathetic Ophthalmia. (18736629)
1915
47
NOTE ON THE BLOOD IN SYMPATHETIC OPHTHALMIA. (20765685)
1911
48
SYMPATHETIC OPHTHALMIA. (20757901)
1898
49
Sympathetic Ophthalmia: A Historical Correction. (20747958)
1875
50
Manchester Eye Hospital: Sympathetic Ophthalmia - Complete Loss of Vision-Restoration of Sight by Operative Means. (21373119)
1842

Variations for Sympathetic Ophthalmia

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Expression for genes affiliated with Sympathetic Ophthalmia

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Search GEO for disease gene expression data for Sympathetic Ophthalmia.

Pathways for genes affiliated with Sympathetic Ophthalmia

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Pathways related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5LTA, TNFRSF1A
2
Show member pathways
9.5LTA, TNFRSF1A
39.3HLA-DQA1, HLA-DRB1
48.8HLA-C, HLA-DQA1, HLA-DRB1
5
Show member pathways
8.8HLA-C, HLA-DQA1, HLA-DRB1
68.8HLA-C, HLA-DQA1, HLA-DRB1
7
Show member pathways
8.8HLA-DQA1, HLA-DRB1, TNFRSF1A
88.8HLA-DQA1, HLA-DRB1, TNFRSF1A
98.7CTLA4, HLA-DQA1, HLA-DRB1
108.7CTLA4, HLA-DQA1, HLA-DRB1
11
Show member pathways
8.7CTLA4, HLA-DQA1, HLA-DRB1
12
Show member pathways
8.7CTLA4, HLA-DQA1, HLA-DRB1
13
TNF Signaling (sino)
Show member pathways
8.2CTLA4, HLA-DQA1, HLA-DRB1
148.1CTLA4, HLA-C, HLA-DQA1, HLA-DRB1
15
Show member pathways
7.8HLA-C, HLA-DQA1, HLA-DRB1, LTA, TNFRSF1A
167.8HLA-C, HLA-DQA1, HLA-DRB1, LTA, TNFRSF1A
17
Show member pathways
7.2CTLA4, HLA-C, HLA-DQA1, HLA-DRB1, LTA, TNFRSF1A
18
Show member pathways
7.2CTLA4, HLA-C, HLA-DQA1, HLA-DRB1, LTA, TNFRSF1A

GO Terms for genes affiliated with Sympathetic Ophthalmia

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Cellular components related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.9HLA-DQA1, HLA-DRB1
2endocytic vesicle membraneGO:00306669.8HLA-DQA1, HLA-DRB1
3clathrin-coated endocytic vesicle membraneGO:00306699.8HLA-DQA1, HLA-DRB1
4trans-Golgi network membraneGO:00325889.8HLA-DQA1, HLA-DRB1
5transport vesicle membraneGO:00306589.7HLA-DQA1, HLA-DRB1
6integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.3HLA-C, HLA-DQA1, HLA-DRB1
7ER to Golgi transport vesicle membraneGO:00125079.3HLA-C, HLA-DQA1, HLA-DRB1
8Golgi membraneGO:00001398.6HLA-C, HLA-DQA1, HLA-DRB1, TNFRSF1A
9integral component of plasma membraneGO:00058877.9CTLA4, HLA-C, HLA-DQA1, HLA-DRB1, TNFRSF1A
10plasma membraneGO:00058867.2CTLA4, HLA-C, HLA-DQA1, HLA-DRB1, LTA, TNFRSF1A

Biological processes related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:00025049.9HLA-DQA1, HLA-DRB1
2interferon-gamma-mediated signaling pathwayGO:00603339.3HLA-C, HLA-DQA1, HLA-DRB1
3antigen processing and presentationGO:00198829.1HLA-C, HLA-DQA1, HLA-DRB1
4T cell costimulationGO:00312959.0CTLA4, HLA-DQA1, HLA-DRB1
5cytokine-mediated signaling pathwayGO:00192218.2HLA-C, HLA-DQA1, HLA-DRB1, TNFRSF1A
6immune responseGO:00069557.1CTLA4, HLA-C, HLA-DQA1, HLA-DRB1, LTA, TNFRSF1A

Molecular functions related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323959.5HLA-DQA1, HLA-DRB1
2peptide antigen bindingGO:00426058.8HLA-C, HLA-DQA1, HLA-DRB1

Sources for Sympathetic Ophthalmia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet