MCID: SYM002
MIFTS: 46

Sympathetic Ophthalmia malady

Categories: Eye diseases, Rare diseases, Immune diseases

Aliases & Classifications for Sympathetic Ophthalmia

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Sources:
10Disease Ontology, 12DISEASES, 51Orphanet, 36MeSH, 65UMLS, 27ICD10, 29ICD9CM, 59SNOMED-CT, 66UMLS via Orphanet, 28ICD10 via Orphanet, 37MESH via Orphanet
See all MalaCards sources

Aliases & Descriptions for Sympathetic Ophthalmia:

Name: Sympathetic Ophthalmia 10 12 51
Ophthalmia, Sympathetic 36 65
 
Sympathetic Uveitis 10 51

Characteristics:

Orphanet epidemiological data:

51
sympathetic ophthalmia:
Inheritance: Not applicable; Age of onset: All ages

Classifications:

Orphanet: 51 
Rare eye diseases


External Ids:

Disease Ontology10 DOID:12029
ICD1027 H44.13
ICD9CM29 360.11
MeSH36 D009879
SNOMED-CT59 75315001
Orphanet51 79098
UMLS via Orphanet66 C0029077
ICD10 via Orphanet28 H44.1
MESH via Orphanet37 D009879
UMLS65 C0029077

Summaries for Sympathetic Ophthalmia

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Wikipedia:68 Sympathetic ophthalmia (SO) is a bilateral diffuse granulomatous uveitis (a kind of inflammation) of... more...

MalaCards based summary: Sympathetic Ophthalmia, also known as ophthalmia, sympathetic, is related to colorectal adenoma and psoriasis, and has symptoms including ciliary hyperaemia An important gene associated with Sympathetic Ophthalmia is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways are OX40 Pathway and Cellular Transformation by HTLV1. Affiliated tissues include eye, liver and heart.

Related Diseases for Sympathetic Ophthalmia

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Diseases related to Sympathetic Ophthalmia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal adenoma10.5HLA-DRB1, LTA
2psoriasis10.5HLA-C, HLA-DRB1
3maculopapular lupus rash10.5HLA-DRB1, IL10
4hemorrhagic fever with renal syndrome10.5HLA-C, HLA-DRB1
5echinococcosis10.4HLA-DRB1, IL10
6nut allergy10.4HLA-DRB1, IL10
7hypersensitivity reaction type ii disease10.4HLA-C, HLA-DRB1
8ichthyosis-hypotrichosis-sclerosing cholangitis syndrome10.4HLA-C, HLA-DRB1
9choroiditis10.4
10retinitis10.4
11dysgammaglobulinemia10.4IL10, LTA
12tucker syndrome10.4HLA-DQA1, HLA-DRB1
13pulmonary coin lesion10.4HLA-DQA1, HLA-DRB1
14metanephric adenoma10.3HLA-DQA1, HLA-DRB1
15endophthalmitis10.3
16intrahepatic gall duct cancer10.3HLA-C, HLA-DRB1
17cataract10.3
18retinal detachment10.3
19squamous cell papilloma10.3HLA-C, LTA
20vogt-koyanagi-harada disease10.2
21melanoma10.2
22congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome10.2HLA-DRB1, TNF
23microsomia hemifacial radial defects10.2HLA-DRB1, TNF
24autoimmune polyglandular syndrome type 210.2HLA-DRB1, TNF
25best1 retinopathy10.2HLA-DRB1, TNF
26non-distal monosomy 10q10.2HLA-DRB1, TNF
27androgen insensitivity syndrome, mild10.2HLA-DRB1, TNF
28lujo hemorrhagic fever10.2HLA-DRB1, TNF
29rhizomelic dysplasia patterson lowry type10.2HLA-DRB1, TNF
30disseminated chorioretinitis10.2HLA-C, IL10
31collagenous colitis10.2HLA-DRB1, TNF
32noonan-like/multiple giant cell lesion syndrome10.2HLA-DRB1, TNF
33lymphocytic choriomeningitis10.2HLA-DRB1, TNF
34hepatoid adenocarcinoma10.1HLA-DRB1, TNF
35secretory diarrhea10.1HLA-DRB1, TNF
36hypopharynx cancer10.1HLA-DRB1, TNF
37thoracic aortic aneurysm10.1CRYAA, TNF
38byssinosis10.1HLA-DRB1, TNF
39malignant sertoli-leydig cell tumor of ovary10.1LTA, TNF
40blue color blindness10.1HLA-DRB1, TNF
41listeriosis10.1LTA, TNF
42keratomalacia10.1HLA-DRB1, TNF
43spondylocamptodactyly10.1LTA, TNF
44diffuse intraductal papillomatosis10.1LTA, TNF
45punctate palmoplantar keratoderma type 210.1IL10, TNF
46primary progressive freezing gait10.0IL10, TNF
47kearns-sayre syndrome10.0IL10, TNF
48multifocal lymphangioendotheliomatosis with thrombocytopenia10.0IL10, TNF
49alternating exotropia10.0IL10, TNF
50acneiform dermatitis10.0HLA-C, TNF

Graphical network of the top 20 diseases related to Sympathetic Ophthalmia:



Diseases related to sympathetic ophthalmia

Symptoms for Sympathetic Ophthalmia

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UMLS symptoms related to Sympathetic Ophthalmia:


ciliary hyperaemia

Drugs & Therapeutics for Sympathetic Ophthalmia

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Drugs for Sympathetic Ophthalmia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
TriamcinoloneapprovedPhase 1, Phase 2448124-94-731307
Synonyms:
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione
11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11beta,16alpha,17alpha,21-Tetrahydroxy-9alpha-fluoro-1,4-pregnadiene-3,20-dione
124-94-7
4-08-00-03629 (Beilstein Handbook Reference)
83474-03-7
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-16-alpha-hydroxyprednisolone
9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy
9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-hydroxyprednisolone
9α-fluoro-16α-hydroxyprednisolone
AC-2072
AC1L1LDH
AC1Q5HJC
Adcortyl
Allernaze
Aristocort
Aristocort A
Aristocort Tablets
Aristogel
Aristospan
Azmacort
BPBio1_000154
BRD-K77554836-001-03-3
BRN 2341955
BSPBio_000140
Bio-0662
C21H27FO6
CHEMBL1451
CID31307
CL 19823
Celeste
Cinolone
Cinolone-T
D00385
D014221
DB00620
Delphicort
EINECS 204-718-7
EU-0101179
Fluoxiprednisolone
Fluoxyprednisolone
Flutex
Fougera
HMS1568G22
HMS2090D12
HSDB 3194
Kenacort
Kenacort (TN)
Kenacort-A
Kenacort-AG
Kenacort-Ag
Kenalog
Kenalog in Orabase
Kenalog-10
Kenalog-40
Kenalog-H
LS-698
Ledercort
Lopac0_001179
MLS000028542
MLS001066543
 
MLS002695935
MolPort-002-528-981
Mycolog
NCGC00021580-03
NCGC00021580-04
NCGC00021580-05
NCGC00021580-06
NCGC00021580-07
NCI60_000750
NSC 13397
NSC13397
Nasacort
Nasacort Aq
Nasacort Hfa
Omcilon
Omicilon
Oracort
Oralone
Orion
Polcortolon
Pregna-1,4-diene-3,20-dio
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)
Prestwick0_000120
Prestwick1_000120
Prestwick2_000120
Prestwick3_000120
Prestwick_438
Rodinolone
S1933_Selleck
SK-Triamcinolone
SMP1_000300
SMR000058333
SPBio_002079
Sk-Triamcinolone
T6376_SIGMA
TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))
Tiamcinolonum
Tiamcinolonum [INN-Latin]
Tri-Nasal
Triacet
Triacort
Triam-Tablinen
Triamcet
Triamcinalone
Triamcinlon
Triamcinolon
Triamcinolona
Triamcinolona [INN-Spanish]
Triamcinolone (JP15/USP/INN)
Triamcinolone Acetonide
Triamcinolone [USAN:INN:BAN:JAN]
Triamcinolone acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Triamcinolonum
Triamcinolonum [INN]
Trianex
Triatex
Tricortale
Triderm
Triesence
Trilone
Tristoject
Trymex
UNII-1ZK20VI6TY
Vetalog
Volon
Volon A
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ
ZINC03882036
droxypregna-1,4-diene-3,20-dione
ione
nchembio.2007.53-comp7
triamcinolone
2triamcinolone acetonidePhase 1, Phase 2448
3Triamcinolone diacetatePhase 1, Phase 2448
4Triamcinolone hexacetonidePhase 1, Phase 2448
5Anti-Inflammatory AgentsPhase 1, Phase 28478
6Immunosuppressive AgentsPhase 1, Phase 210422
7glucocorticoidsPhase 1, Phase 23896
8Immunologic FactorsPhase 1, Phase 218483
9Hormone AntagonistsPhase 1, Phase 210002
10HormonesPhase 1, Phase 211748
11Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 1, Phase 29988
12
Verteporfinapproved, investigational83129497-78-55362420
Synonyms:
Verteporfin
Verteporfina
 
Verteporfinum
Vertéporfine
Visudyne
13Dermatologic Agents4555
14Photosensitizing Agents374

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat UveitisCompletedNCT01789320Phase 1, Phase 2
2Safety and Efficacy of AIN457 in Noninfectious UveitisCompletedNCT00685399Phase 2
3Safety Study of Conventional Versus Micropulse Transscleral Cyclophotocoagulation in Treating End-Stage GlaucomaRecruitingNCT00349414Phase 1, Phase 2
4Adjunctive Photodynamic Therapy + Aflibercept vs. Afilbercept Alone for PDA in NV AMDNot yet recruitingNCT02457026

Search NIH Clinical Center for Sympathetic Ophthalmia


Cochrane evidence based reviews: ophthalmia, sympathetic

Genetic Tests for Sympathetic Ophthalmia

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Anatomical Context for Sympathetic Ophthalmia

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MalaCards organs/tissues related to Sympathetic Ophthalmia:

33
Eye, Liver, Heart, Lung, B cells, Prostate, Endothelial

Animal Models for Sympathetic Ophthalmia or affiliated genes

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Publications for Sympathetic Ophthalmia

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Articles related to Sympathetic Ophthalmia:

(show top 50)    (show all 317)
idTitleAuthorsYear
1
AN ATYPICAL CASE OF SYMPATHETIC OPHTHALMIA AFTER LIMBAL CORNEAL LACERATION. (27124790)
2016
2
Presumed sympathetic ophthalmia after scleral buckling surgery. (25383825)
2013
3
Reversible retinal changes in the acute stage of sympathetic ophthalmia seen on spectral domain optical coherence tomography. (21331811)
2011
4
Sympathetic ophthalmia: enucleation or evisceration? (21876595)
2011
5
A case of sympathetic ophthalmia presenting with extraocular symptoms and conjunctival pigmentation after repeated 23-gauge vitrectomy. (20662657)
2010
6
Sympathetic ophthalmia following postoperative endophthalmitis and evisceration. (20596271)
2010
7
Periocular injections of triamcinolone for sympathetic ophthalmia. (20572826)
2010
8
Development of sympathetic ophthalmia following globe injury. (20137482)
2009
9
Subretinal hypopyon in sympathetic ophthalmia. (19412871)
2009
10
Intravitreal steroid slow-release device replacing repeated intravitreal triamcinolone injections for sympathetic ophthalmia. (18850570)
2008
11
Sympathetic ophthalmia in Singapore: new trends in an old disease. (16028023)
2006
12
Sympathetic ophthalmia following postoperative bacterial endophthalmitis: a clinicopathologic study. (16490496)
2006
13
Bilateral exudative retinal detachments as initial presentation of sympathetic ophthalmia in Turner syndrome. (16883368)
2006
14
Repeated intravitreal triamcinolone acetonide for chronic sympathetic ophthalmia. (16704716)
2006
15
Intravitreal triamcinolone acetonide in sympathetic ophthalmia. (15756580)
2005
16
Immunopathology of progressive subretinal fibrosis: a variant of sympathetic ophthalmia. (15364234)
2004
17
Sympathetic ophthalmia associated with ocular and cerebral vasculitis: an angiographic and radiologic study. (12948320)
2003
18
Incidence of sympathetic ophthalmia after penetrating eye injury and choice of treatment. (12789598)
2002
19
Sympathetic ophthalmia after three pars plana vitrectomies without prior ocular injury. (10950423)
2000
20
Sympathetic ophthalmia associated with antecedent adherent leucoma--a rare association. (9686861)
1998
21
Immunogenetic study of sympathetic ophthalmia. (9062965)
1997
22
Chlorambucil therapy in sympathetic ophthalmia. (7709973)
1995
23
Sympathetic ophthalmia. (10155637)
1994
24
Successfully treated sympathetic ophthalmia with typical histological confirmation. (8485440)
1993
25
Sympathetic ophthalmia after cyclocryotherapy of neovascular glaucoma without ocular penetration. (8446333)
1993
26
Surgical treatment of sympathetic ophthalmia. (1794786)
1991
27
A historical review of sympathetic ophthalmia and its epidemiology. (2678549)
1989
28
Sympathetic ophthalmia following neodymium:YAG cyclotherapy. (2779962)
1989
29
Delayed onset sympathetic ophthalmia. (3670198)
1987
30
Histologic and immunopathologic findings in sympathetic ophthalmia. (3994570)
1985
31
Sympathetic ophthalmia. (6479777)
1984
32
Effect of corticosteroid treatment and enucleation on the visual prognosis of sympathetic ophthalmia. (6614106)
1983
33
Recent advances in sympathetic ophthalmia. (396680)
1979
34
Sympathetic ophthalmia. A long-term follow-up. (629672)
1978
35
Sympathetic ophthalmia in Canada. (4274314)
1972
36
Sympathetic ophthalmia after couching operation. (4668490)
1972
37
Lymphocyte-stimulating activity of ocular tissues in sympathetic ophthalmia. (5124018)
1971
38
Observations on sympathetic ophthalmia. (5904961)
1966
39
Sympathetic Ophthalmia: A Case Treated by Prolonged Use of Corticotropin and Adrenal Steroids. (16693596)
1960
40
Sympathetic ophthalmia controlled by continuous cortisone therapy over a four-year period. (13458314)
1957
41
Sympathetic ophthalmia treated with cortisone. (14923790)
1952
42
Sympathetic ophthalmia. (15412255)
1950
43
The important complications of cataract surgery exclusive of sympathetic ophthalmia. (15407741)
1949
44
Malignant melanoma of the choroid with sympathetic ophthalmia. (18132900)
1949
45
Sympathetic ophthalmia or phacoanaphylaxis? (18874349)
1948
46
Case of Sympathetic Ophthalmia. (18736629)
1915
47
NOTE ON THE BLOOD IN SYMPATHETIC OPHTHALMIA. (20765685)
1911
48
SYMPATHETIC OPHTHALMIA. (20757901)
1898
49
Sympathetic Ophthalmia: A Historical Correction. (20747958)
1875
50
Manchester Eye Hospital: Sympathetic Ophthalmia - Complete Loss of Vision-Restoration of Sight by Operative Means. (21373119)
1842

Variations for Sympathetic Ophthalmia

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Expression for genes affiliated with Sympathetic Ophthalmia

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Search GEO for disease gene expression data for Sympathetic Ophthalmia.

Pathways for genes affiliated with Sympathetic Ophthalmia

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Pathways related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathwaysScoreTop Affiliating Genes
19.5IL10, LTA
2
Show member pathways
9.2LTA, TNF
39.2LTA, TNF
4
Show member pathways
9.1IL10, TNF
59.1IL10, TNF
69.1IL10, TNF
79.1IL10, TNF
8
Show member pathways
9.0HLA-C, HLA-DQA1, HLA-DRB1
99.0HLA-C, HLA-DQA1, HLA-DRB1
109.0HLA-C, HLA-DQA1, HLA-DRB1
119.0HLA-DQA1, HLA-DRB1, IL10
128.8HLA-DRB1, IL10, TNF
13
Show member pathways
8.7IL10, LTA, TNF
148.7IL10, LTA, TNF
158.7IL10, LTA, TNF
168.7HLA-DQA1, HLA-DRB1, TNF
178.4HLA-C, HLA-DQA1, HLA-DRB1, IL10
18
Show member pathways
8.2HLA-C, IL10, LTA, TNF
198.1HLA-DQA1, HLA-DRB1, IL10, TNF
20
Show member pathways
8.1HLA-DQA1, HLA-DRB1, IL10, TNF
21
Show member pathways
8.1HLA-C, HLA-DQA1, LTA, TNF
227.7HLA-C, HLA-DQA1, HLA-DRB1, LTA, TNF
23
Show member pathways
7.7HLA-C, HLA-DQA1, HLA-DRB1, LTA, TNF
24
Show member pathways
7.2HLA-C, HLA-DQA1, HLA-DRB1, IL10, LTA, TNF

GO Terms for genes affiliated with Sympathetic Ophthalmia

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Cellular components related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.6HLA-C, HLA-DQA1
2trans-Golgi network membraneGO:00325889.5HLA-DQA1, HLA-DRB1
3ER to Golgi transport vesicle membraneGO:00125078.7HLA-C, HLA-DQA1, HLA-DRB1

Biological processes related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:000250410.1HLA-DQA1, HLA-DRB1
2positive regulation of chronic inflammatory response to antigenic stimulusGO:00028769.8LTA, TNF
3receptor biosynthetic processGO:00328009.7IL10, TNF
4negative regulation of cytokine secretion involved in immune responseGO:00027409.7IL10, TNF
5defense response to Gram-positive bacteriumGO:00508309.6LTA, TNF
6negative regulation of growth of symbiont in hostGO:00441309.6IL10, TNF
7negative regulation of interleukin-6 productionGO:00327159.5IL10, TNF
8positive regulation of interferon-gamma productionGO:00327299.5LTA, TNF
9positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.5IL10, TNF
10antigen processing and presentationGO:00198829.4HLA-C, HLA-DQA1, HLA-DRB1
11positive regulation of apoptotic processGO:00430659.3LTA, TNF
12response to organic substanceGO:00100339.1IL10, TNF
13defense response to bacteriumGO:00427429.0IL10, TNF
14immune responseGO:00069558.8HLA-DRB1, IL10, TNF

Sources for Sympathetic Ophthalmia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet