MCID: SYM002
MIFTS: 43

Sympathetic Ophthalmia

Categories: Eye diseases, Rare diseases, Immune diseases

Aliases & Classifications for Sympathetic Ophthalmia

MalaCards integrated aliases for Sympathetic Ophthalmia:

Name: Sympathetic Ophthalmia 12 55 14
Ophthalmia, Sympathetic 41 69
Sympathetic Uveitis 12 55

Characteristics:

Orphanet epidemiological data:

55
sympathetic ophthalmia
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 55  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:12029
ICD10 32 H44.13
ICD9CM 34 360.11
MeSH 41 D009879
SNOMED-CT 64 75315001
Orphanet 55 ORPHA79098
MESH via Orphanet 42 D009879
UMLS via Orphanet 70 C0029077
ICD10 via Orphanet 33 H44.1
UMLS 69 C0029077

Summaries for Sympathetic Ophthalmia

MalaCards based summary : Sympathetic Ophthalmia, also known as ophthalmia, sympathetic, is related to autoimmune disease and spondylarthropathy. An important gene associated with Sympathetic Ophthalmia is CRYAA (Crystallin Alpha A), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Triamcinolone and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include eye and retina.

Wikipedia : 72 Sympathetic ophthalmia (SO) or Sympathetic uveitis is a bilateral diffuse granulomatous uveitis (a kind... more...

Related Diseases for Sympathetic Ophthalmia

Diseases related to Sympathetic Ophthalmia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 autoimmune disease 28.1 CTLA4 HLA-DQA1 HLA-DRB1 PDCD1 TNF
2 spondylarthropathy 10.4 LTA TNF
3 transient hypogammaglobulinemia 10.4 LTA TNF
4 streptococcal toxic-shock syndrome 10.4 LTA TNF
5 choroiditis 10.4
6 retinitis 10.4
7 null-cell leukemia 10.4 LTA TNF
8 mucocutaneous leishmaniasis 10.4 LTA TNF
9 idiopathic achalasia 10.4 LTA TNF
10 microscopic polyangiitis 10.3 HLA-DRB1 TNF
11 listeria meningitis 10.3 LTA TNF
12 chronic beryllium disease 10.3 HLA-DRB1 TNF
13 lichen sclerosus 10.3 HLA-DRB1 TNF
14 monoclonal gammopathy of uncertain significance 10.3 LTA TNF
15 post-transplant lymphoproliferative disease 10.3 LTA TNF
16 actinic prurigo 10.3 HLA-DRB1 TNF
17 endophthalmitis 10.3
18 nontuberculous mycobacterial lung disease 10.3 HLA-DRB1 TNF
19 microscopic colitis 10.3 HLA-DRB1 TNF
20 central nervous system vasculitis 10.3 HLA-DRB1 TNF
21 rheumatoid vasculitis 10.3 HLA-DRB1 TNF
22 alveolar echinococcosis 10.3 HLA-DRB1 TNF
23 acute respiratory distress syndrome 10.3 LTA TNF
24 retinal detachment 10.3
25 cataract 10.3
26 hemorrhagic fever 10.3 HLA-DRB1 TNF
27 panuveitis 10.2 HLA-DRB1 TNF
28 palindromic rheumatism 10.2 HLA-DRB1 TNF
29 trachoma 10.2 HLA-C TNF
30 dengue shock syndrome 10.2 HLA-DRB1 TNF
31 hemorrhagic fever with renal syndrome 10.2 HLA-DRB1 TNF
32 rheumatic fever 10.2 HLA-DRB1 TNF
33 idiopathic neutropenia 10.2 HLA-DRB1 TNF
34 progressive multifocal leukoencephalopathy 10.2 PDCD1 TNF
35 vogt-koyanagi-harada disease 10.2
36 melanoma 10.2
37 pityriasis rosea 10.2 HLA-C HLA-DRB1
38 anterior uveitis 10.2 CTLA4 TNF
39 mixed connective tissue disease 10.2 HLA-DRB1 TNF
40 typhoid fever 10.2 LTA TNF
41 echinococcosis 10.2 HLA-DRB1 TNF
42 type 1 diabetes mellitus 12 10.1 CTLA4 HLA-DRB1
43 autoimmune addison disease 10.1 CTLA4 HLA-DRB1
44 anca-associated vasculitis 10.1 CTLA4 HLA-DRB1
45 tonsillitis 10.1 LTA TNF
46 dengue hemorrhagic fever 10.1 HLA-DRB1 TNF
47 pemphigus foliaceus 10.1 CTLA4 HLA-DRB1
48 myasthenic syndrome, congenital, 7, presynaptic 10.1 CTLA4 PDCD1
49 paracoccidioidomycosis 10.1 CTLA4 TNF
50 optic neuritis 10.1 HLA-DRB1 LTA TNF

Graphical network of the top 20 diseases related to Sympathetic Ophthalmia:



Diseases related to Sympathetic Ophthalmia

Symptoms & Phenotypes for Sympathetic Ophthalmia

Drugs & Therapeutics for Sympathetic Ophthalmia

Drugs for Sympathetic Ophthalmia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 1, Phase 2 124-94-7 31307
2
Benzocaine Approved, Investigational Phase 2 1994-09-7, 94-09-7 2337
3 tannic acid Approved, Nutraceutical Phase 2
4 Anti-Inflammatory Agents Phase 1, Phase 2
5 glucocorticoids Phase 1, Phase 2
6 Hormone Antagonists Phase 1, Phase 2
7 Hormones Phase 1, Phase 2
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
9 Immunosuppressive Agents Phase 1, Phase 2
10 triamcinolone acetonide Phase 1, Phase 2
11 Triamcinolone diacetate Phase 1, Phase 2
12 Triamcinolone hexacetonide Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety Study of Conventional Versus Micropulse Transscleral Cyclophotocoagulation in Treating End-Stage Glaucoma Unknown status NCT00349414 Phase 1, Phase 2
2 Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis Completed NCT01789320 Phase 1, Phase 2 triamcinolone acetonide (Triesence®)
3 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
4 Adjunctive Photodynamic Therapy + Aflibercept vs. Afilbercept Alone for PDA in NV AMD Withdrawn NCT02457026 Aflibercept;Triamcinolone Acetonide;Verteporfin

Search NIH Clinical Center for Sympathetic Ophthalmia

Cochrane evidence based reviews: ophthalmia, sympathetic

Genetic Tests for Sympathetic Ophthalmia

Anatomical Context for Sympathetic Ophthalmia

MalaCards organs/tissues related to Sympathetic Ophthalmia:

38
Eye, Retina

Publications for Sympathetic Ophthalmia

Articles related to Sympathetic Ophthalmia:

(show top 50) (show all 329)
# Title Authors Year
1
Postsurgical sympathetic ophthalmia: retrospective analysis of a rare entity. ( 29164454 )
2017
2
Sympathetic Ophthalmia Following Accidental Burn with Hot Water Involving the Other Eye. ( 28910553 )
2017
3
Association of a PDCD1 Polymorphism With Sympathetic Ophthalmia in Han Chinese. ( 28846771 )
2017
4
Sympathetic Ophthalmia. ( 28414613 )
2017
5
Bilateral sensorineural hearing loss secondary to sympathetic ophthalmia in a human leukocyte antigen-A2 positive patient. ( 29118502 )
2017
6
Early Recovery of Sympathetic Ophthalmia with Hearing Loss in a Young Man. ( 29308342 )
2017
7
Sympathetic ophthalmia related to conjunctival invasive squamous-cell carcinoma. ( 28820163 )
2017
8
Cyclophotocoagulation-induced sympathetic ophthalmia in a Coats' disease patient supported by histopathology and immunohistochemistry. ( 28820164 )
2017
9
Lymphocytic Meningitis in Patients with Sympathetic Ophthalmia. ( 28281853 )
2017
10
Long-Term Drug-Free Remission and Visual Outcomes in Sympathetic Ophthalmia. ( 26808121 )
2016
11
AN ATYPICAL CASE OF SYMPATHETIC OPHTHALMIA AFTER LIMBAL CORNEAL LACERATION. ( 27124790 )
2016
12
Characteristics of Sympathetic Ophthalmia in a Single International Center. ( 27651849 )
2016
13
A rare case of atypical sympathetic ophthalmia post therapeutic keratoplasty. ( 27638462 )
2016
14
Multimodal Imaging in Sympathetic Ophthalmia. ( 27960610 )
2016
15
Sympathetic ophthalmia following a conjunctival flap procedure for corneal perforation. ( 26976837 )
2016
16
Spontaneous dislocation of a fluocinolone acetonide implant (retisert) into the anterior chamber and its successful extraction in sympathetic ophthalmia. ( 25411930 )
2015
17
A case of sympathetic ophthalmia after 23-gauge transconjunctival sutureless vitrectomy. ( 26028951 )
2015
18
Sympathetic ophthalmia caused by a severe ocular chemical burn: a case report and literature review. ( 25932266 )
2015
19
Bilateral hearing impairment as the initial symptom of sympathetic ophthalmia. ( 25720920 )
2015
20
Sympathetic Ophthalmia after Ocular Wasp Sting. ( 26635462 )
2015
21
SYMPATHETIC OPHTHALMIA: Clinicopathologic Correlation in a Consecutive Case Series. ( 25719985 )
2015
22
Enhanced depth imaging OCT (EDI-OCT) findings in acute phase of sympathetic ophthalmia. ( 25772275 )
2015
23
Sympathetic ophthalmia after diode laser cyclophotocoagulation: now an issue in informed consent. ( 25103662 )
2014
24
Sympathetic ophthalmia following diode laser cyclophotocoagulation. ( 24711656 )
2014
25
Gender differences in vogt-koyanagi-harada disease and sympathetic ophthalmia. ( 24734166 )
2014
26
Spectral-Domain Optical Coherence Tomography of Sympathetic Ophthalmia With Dalen-Fuchs Nodules. ( 25347826 )
2014
27
Classical pathology of sympathetic ophthalmia presented in a unique case. ( 25067979 )
2014
28
Adalimumab for pediatric sympathetic ophthalmia. ( 25010359 )
2014
29
Multiple serous retinal detachments seen on wide-field imaging in a patient with sympathetic ophthalmia. ( 25171189 )
2014
30
Long-term, drug-free remission of sympathetic ophthalmia with high-dose, short-term chlorambucil therapy. ( 24572676 )
2014
31
Presumed sympathetic ophthalmia after scleral buckling surgery. ( 25383825 )
2013
32
High definition spectral domain optical coherence tomography of retinal pigment epithelial rip in a case of sympathetic ophthalmia. ( 23514588 )
2013
33
Sympathetic ophthalmia following enucleation. ( 22124788 )
2013
34
Sympathetic Ophthalmia in Pediatric Age Group: Clinical Features and Challenges in Management in a Tertiary Center in Southern India. ( 24131076 )
2013
35
Sympathetic ophthalmia with sensorineural deafness - report of a case. ( 24225003 )
2013
36
Reversible alopecia in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia. ( 23514340 )
2013
37
Sympathetic ophthalmia: to the twenty-first century and beyond. ( 23724856 )
2013
38
Incidence of hypotony and sympathetic ophthalmia following trans-scleral cyclophotocoagulation for glaucoma and a report of risk factors. ( 23433313 )
2013
39
Expression of I+-crystallin in the retina of human sympathetic ophthalmia. ( 22052021 )
2012
40
Immunopathologic processes in sympathetic ophthalmia as signified by microRNA profiling. ( 22589448 )
2012
41
Mitochondrial oxidative stress initiates visual loss in sympathetic ophthalmia. ( 22476625 )
2012
42
Sympathetic ophthalmia in HIV infection. A clinicopathological case report. ( 22411458 )
2012
43
Update on sympathetic ophthalmia. ( 22346110 )
2012
44
Missed perforation presenting as sympathetic ophthalmia in an adolescent Malay girl. ( 22914237 )
2012
45
Sympathetic ophthalmia: a review of literature. ( 22677732 )
2012
46
Imaging for sympathetic ophthalmia: impact on the diagnosis and management. ( 22954939 )
2012
47
Presumed occult globe rupture resulting in sympathetic ophthalmia. ( 22200914 )
2012
48
Multimodality diagnostic imaging in a case of sympathetic ophthalmia. ( 22594960 )
2012
49
Continued vision loss from progressive expansion of inactive chorioretinal scars in a myopic patient with well-controlled sympathetic ophthalmia. ( 25389936 )
2012
50
Sympathetic ophthalmia after proton beam irradiation for choroA^dal melanoma. ( 22646709 )
2012

Variations for Sympathetic Ophthalmia

Expression for Sympathetic Ophthalmia

Search GEO for disease gene expression data for Sympathetic Ophthalmia.

Pathways for Sympathetic Ophthalmia

Pathways related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 LTA PDCD1
2
Show member pathways
13.17 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 PDCD1
3
Show member pathways
13.03 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF
4
Show member pathways
12.49 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF
5
Show member pathways
12.36 HLA-DQA1 HLA-DRB1 TNF
6 12.32 CTLA4 PDCD1 TNF
7
Show member pathways
12.28 HLA-C HLA-DQA1 HLA-DRB1
8
Show member pathways
12.2 CTLA4 PDCD1 TNF
9
Show member pathways
12.17 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF
10
Show member pathways
12.15 CTLA4 HLA-DQA1 HLA-DRB1
11 12.06 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF
12 12.05 HLA-C HLA-DQA1 HLA-DRB1
13
Show member pathways
12.01 HLA-DQA1 HLA-DRB1 TNF
14 11.97 HLA-DQA1 HLA-DRB1 TNF
15
Show member pathways
11.91 CTLA4 HLA-DQA1 HLA-DRB1 PDCD1
16
Show member pathways
11.88 HLA-C LTA TNF
17 11.87 HLA-C HLA-DQA1 HLA-DRB1
18
Show member pathways
11.69 HLA-DQA1 HLA-DRB1 PDCD1
19 11.62 HLA-DQA1 HLA-DRB1 TNF
20 11.58 CTLA4 HLA-DQA1 HLA-DRB1 TNF
21
Show member pathways
11.56 HLA-DQA1 HLA-DRB1
22 11.46 CTLA4 HLA-DQA1 HLA-DRB1
23 11.41 CTLA4 PDCD1
24 11.39 HLA-DQA1 HLA-DRB1
25 11.37 LTA TNF
26
Show member pathways
11.32 LTA TNF
27 11.28 CTLA4 LTA PDCD1 TNF
28 11.18 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 PDCD1
29 11.08 CTLA4 PDCD1
30 11.05 HLA-DRB1 TNF

GO Terms for Sympathetic Ophthalmia

Cellular components related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.91 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 LTA PDCD1
2 external side of plasma membrane GO:0009897 9.46 CTLA4 HLA-DRB1 PDCD1 TNF
3 transport vesicle membrane GO:0030658 9.4 HLA-DQA1 HLA-DRB1
4 clathrin-coated endocytic vesicle membrane GO:0030669 9.32 HLA-DQA1 HLA-DRB1
5 MHC class II protein complex GO:0042613 9.26 HLA-DQA1 HLA-DRB1
6 ER to Golgi transport vesicle membrane GO:0012507 9.13 HLA-C HLA-DQA1 HLA-DRB1
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.8 HLA-C HLA-DQA1 HLA-DRB1

Biological processes related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.8 CTLA4 HLA-C HLA-DQA1 HLA-DRB1
2 positive regulation of apoptotic process GO:0043065 9.73 CTLA4 LTA PDCD1 TNF
3 interferon-gamma-mediated signaling pathway GO:0060333 9.58 HLA-C HLA-DQA1 HLA-DRB1
4 humoral immune response GO:0006959 9.54 LTA PDCD1 TNF
5 positive regulation of interferon-gamma production GO:0032729 9.52 LTA TNF
6 negative regulation of T cell proliferation GO:0042130 9.51 CTLA4 HLA-DRB1
7 negative regulation of growth of symbiont in host GO:0044130 9.48 LTA TNF
8 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.46 HLA-DQA1 HLA-DRB1
9 antigen processing and presentation GO:0019882 9.43 HLA-C HLA-DQA1 HLA-DRB1
10 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.32 LTA TNF
11 T cell costimulation GO:0031295 9.26 CTLA4 HLA-DQA1 HLA-DRB1 PDCD1
12 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.16 LTA TNF
13 immune response GO:0006955 9.1 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF

Molecular functions related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 9.16 LTA TNF
2 MHC class II receptor activity GO:0032395 8.96 HLA-DQA1 HLA-DRB1
3 peptide antigen binding GO:0042605 8.8 HLA-C HLA-DQA1 HLA-DRB1

Sources for Sympathetic Ophthalmia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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