MCID: SYM002
MIFTS: 51

Sympathetic Ophthalmia malady

Eye diseases category

Summaries for Sympathetic Ophthalmia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Sympathetic ophthalmia (SO) is a bilateral diffuse granulomatous uveitis (a kind of inflammation) of... more...

MalaCards: Sympathetic Ophthalmia, also known as sympathetic uveitis, is related to vogt-koyanagi-harada disease and melanoma. An important gene associated with Sympathetic Ophthalmia is TYRP1 (tyrosinase-related protein 1), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The compounds endotoxin and ivig have been mentioned in the context of this disorder. Affiliated tissues include eye and retina, and related mouse phenotypes are vision/eye and skeleton.

Aliases & Classifications for Sympathetic Ophthalmia

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8Disease Ontology, 48Orphanet, 60UMLS, 34MeSH, 27ICD9CM, 56SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Characteristics (Orphanet epidemiological data):

48
sympathetic ophthalmia:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Variable


Aliases & Descriptions:

sympathetic ophthalmia 8 48
sympathetic uveitis 8 48
ophthalmia, sympathetic 60


External Ids:

Disease Ontology8 DOID:12029
MeSH34 D009879
ICD9CM27 360.11
MESH via Orphanet35 D009879
SNOMED-CT56 75315001
ICD10 via Orphanet26 H44.1
SNOMED-CT via Orphanet57 75315001
UMLS via Orphanet61 C0029077

Related Diseases for Sympathetic Ophthalmia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Sympathetic Ophthalmia:



Diseases related to sympathetic ophthalmia

Clinical Features for Sympathetic Ophthalmia

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Drugs & Therapeutics for Sympathetic Ophthalmia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Sympathetic Ophthalmia

Drug clinical trials:

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Search NIH Clinical Center for Sympathetic Ophthalmia

Search CenterWatch for Sympathetic Ophthalmia

Genetic Tests for Sympathetic Ophthalmia

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Anatomical Context for Sympathetic Ophthalmia

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32MalaCards
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MalaCards organs/tissues related to Sympathetic Ophthalmia:

32
Eye, Retina

Animal Models for Sympathetic Ophthalmia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sympathetic Ophthalmia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.7TYRP1, CRYAA
2MP:00053909.5TYRP1, LTA, TNFRSF1A
3MP:00020068.0CCL2, TNFRSF1A, TNF, TYRP1, IL10
4MP:00053707.8CCL2, TNFRSF1A, TNF, LTA, IL10
5MP:00053977.7IL10, LTA, HLA-DQA1, TNF, TNFRSF1A, CCL2

Publications for Sympathetic Ophthalmia

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50PubMed
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Articles related to Sympathetic Ophthalmia:

(show top 50)    (show all 297)
idTitleAuthorsYear
1
Sympathetic Ophthalmia in Pediatric Age Group: Clinical Features and Challenges in Management in a Tertiary Center in Southern India. (24131076)
2013
2
Mitochondrial oxidative stress initiates visual loss in sympathetic ophthalmia. (22476625)
2012
3
Efficacy of infliximab therapy in two patients with sympathetic ophthalmia. (21484652)
2011
4
A case of sympathetic ophthalmia presenting with extraocular symptoms and conjunctival pigmentation after repeated 23-gauge vitrectomy. (20662657)
2010
5
Sympathetic ophthalmia: what have we learned? (19878754)
2009
6
Sympathetic ophthalmia: incidence of ocular complications and vision loss in the sympathizing eye. (19665105)
2009
7
Photoreceptor oxidative damage in sympathetic ophthalmia. (18514610)
2008
8
Sympathetic ophthalmia after ruthenium plaque brachytherapy. (17322472)
2007
9
Sympathetic ophthalmia following postoperative bacterial endophthalmitis: a clinicopathologic study. (16490496)
2006
10
Intravitreal triamcinolone acetonide in sympathetic ophthalmia. (15756580)
2005
11
Cytokine gene polymorphism in sympathetic ophthalmia. (16249504)
2005
12
Sympathetic ophthalmia following ciliary body laser cyclophotocoagulation for rubeotic glaucoma. (15068439)
2004
13
Intravitreal triamcinolone acetonide for treatment of sympathetic ophthalmia. (14962439)
2004
14
Incidence of sympathetic ophthalmia after penetrating eye injury and choice of treatment. (12789598)
2002
15
Sympathetic ophthalmia after three pars plana vitrectomies without prior ocular injury. (10950423)
2000
16
Sympathetic ophthalmia risk following vitrectomy: should we counsel patients? (10781505)
2000
17
Sympathetic ophthalmia associated with antecedent adherent leucoma--a rare association. (9686861)
1998
18
Sympathetic ophthalmia following cyclocryotherapy with histopathologic correlation. (8976524)
1996
19
Sympathetic ophthalmia. (10155637)
1994
20
Adhesion molecule expression in acute and fibrotic sympathetic ophthalmia. (8293668)
1993
21
Inflammatory cellular kinetics in sympathetic ophthalmia a study of 29 traumatized (exciting) eyes. (22822781)
1993
22
Fluorescein angiographic appearance of Dalen-Fuchs nodules in sympathetic ophthalmia. (8484659)
1993
23
Sympathetic ophthalmia complicating helium ion irradiation of a choroidal melanoma. (3675290)
1987
24
Granulomas in sympathetic ophthalmia and sarcoidosis. Immunohistochemical study. (2579628)
1985
25
Sympathetic ophthalmia: induced by vitrectomy not by trauma. (6748363)
1984
26
Atypical histopathologic features in sympathetic ophthalmia. A study of a hundred cases. (7068330)
1982
27
Sympathetic ophthalmia. Ample room for controversy. (542889)
1979
28
Posterior form sympathetic ophthalmia. (1246807)
1975
29
Histologic variations related to race in sympathetic ophthalmia. (4440728)
1974
30
Sympathetic ophthalmia after couching operation. (4668490)
1972
31
A ten-year follow-up on a case of sympathetic ophthalmia. (4332690)
1970
32
Sympathetic ophthalmia, a disappearing disease. (5819666)
1969
33
Treatment of a presumed case of sympathetic ophthalmia with methotrexate. (5943678)
1966
34
Frequency of sympathetic ophthalmia in different parts of the world. (13702350)
1961
35
Uveitis resembling sympathetic ophthalmia induced by sensitization of intraperitoneally implanted eye. (13780181)
1960
36
The relation between Vogt-Koyanagi syndrome and sympathetic ophthalmia; report of a case of Vogt-Koyanagi syndrome. (13411158)
1957
37
Sympathetic ophthalmia. (13293332)
1956
38
Sympathetic ophthalmia treated with cortisone. (14923790)
1952
39
Sympathetic ophthalmia. (14894022)
1952
40
Sympathetic ophthalmia. (14885977)
1951
41
Observations in clinical practice and animal experiments in sympathetic ophthalmia. (18228866)
1949
42
Extraction of cataract in a case of sympathetic ophthalmia. (15397181)
1949
43
Benignant course of sympathetic ophthalmia; four cases of the transient S. O. of Meller. (20250963)
1947
44
Atophanyl in the Treatment of Sympathetic Ophthalmia. (20323001)
1944
45
Atophanyl in Sympathetic Ophthalmia. (20323078)
1944
46
ANALYSIS OF CASES OF SYMPATHETIC OPHTHALMIA FROM SCHOOLS FOR BLIND CHILDREN. (20781262)
1938
47
A Case of Sympathetic Ophthalmia Observed Over a Period of Six Years. (20316666)
1928
48
Two cases of sympathetic ophthalmia. (16692141)
1908
49
Sympathetic ophthalmia caused by glioma-retinae. (16691928)
1899
50
Enucleation of Eye for Sympathetic Ophthalmia. (16691744)
1868

Genetic Variations for Sympathetic Ophthalmia

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Expression for genes affiliated with Sympathetic Ophthalmia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sympathetic Ophthalmia

Search GEO for disease gene expression data for Sympathetic Ophthalmia.

Pathways for genes affiliated with Sympathetic Ophthalmia

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 52R&D Systems, 55SinoBiological
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Pathways related to Sympathetic Ophthalmia according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2LTA
2
Hide members
10.1TNFRSF1A
39.9HLA-DRB1
4
Hide members
9.8TNFRSF1A, LTA
59.6IL10, LTA
6
Hide members
9.5HLA-DRB1, HLA-DQA1
79.3TNFRSF1A, TNF
8
Hide members
9.3TNF, TNFRSF1A
99.3TNFRSF1A, HLA-C, HLA-DQA1
109.2TNF, CCL2
119.0HLA-DQA1, HLA-DRB1, HLA-C
129.0HLA-C, HLA-DRB1, HLA-DQA1
139.0TNFRSF1A, TNF, LTA
14
Hide members
9.0TNFRSF1A, TNF, LTA
15
Hide members
9.0TNFRSF1A, TNF, LTA
16
Hide members
9.0LTA, TNF, TNFRSF1A
17
Hide members
9.0LTA, TNF, TNFRSF1A
18
Hide members
9.0LTA, TNF, TNFRSF1A
19
Hide members
9.0LTA, TNF, TNFRSF1A
20
Hide members
9.0LTA, TNF, TNFRSF1A
219.0LTA, TNF, TNFRSF1A
229.0IL10, HLA-DQA1, HLA-DRB1
23
Hide members
8.8IL10, LTA, TNF
248.8IL10, LTA, TNF
25
Hide members
8.8IL10, TNF, TNFRSF1A
26
Development PDGF signaling via STATs and NF-kB
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8.7IL10, TNF, CCL2
278.6CCL2, TNFRSF1A, TNF, LTA
28
Hide members
8.6CCL2, TNFRSF1A, TNF, LTA
298.5HLA-C, HLA-DRB1, HLA-DQA1, IL10
30
Hide members
8.4CCL2, TNFRSF1A, TNF, IL10
31
Hide members
8.3TNFRSF1A, TNF, HLA-DRB1, HLA-DQA1
32
Hide members
8.2LTA, HLA-DQA1, HLA-C, TNF, TNFRSF1A
33
Hide members
8.1TNF, HLA-DRB1, HLA-DQA1, IL10
34
Hide members
8.1CCL2, TNFRSF1A, TNF, LTA, IL10
35
Hide members
8.1CCL2, TNFRSF1A, TNF, LTA, IL10
367.8IL10, HLA-DQA1, HLA-DRB1, TNF, TNFRSF1A
37
Hide members
7.1CCL2, TNFRSF1A, TNF, HLA-C, HLA-DRB1, HLA-DQA1
38
Hide members
7.0IL10, TNFRSF1A, TNF, HLA-C, HLA-DRB1, HLA-DQA1

Compounds for genes affiliated with Sympathetic Ophthalmia

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Sympathetic Ophthalmia according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.6TNFRSF1A
2ivig4410.6TNFRSF1A
3cycloheximide4410.5LTA
4pentoxifylline44 1111.5LTA
5dexamethasone44 49 28 1113.5LTA
6cyclosporin a44 28 5912.3LTA
7bcma4410.1TNFRSF1A
8aspartate449.9CRYAA, CCL2
9prednisolone44 28 1111.9LTA
10dpa 1449.8HLA-DQA1, HLA-DRB1
11gm-csf44 2810.5IL10, TNF
12cdp571449.4IL10, TNF
13rantes449.4TNFRSF1A, TNF, LTA
14interferon gamma449.4IL10, TNF
15blys449.2TNFRSF1A, TNF, IL10
16n-tosyl-l-phenylalanine chloromethyl ketone449.1TNF, CCL2
17mip 1alpha449.1IL10, TNF, CCL2
18il-12449.1CCL2, TNF, IL10
195 aminosalicylic acid449.1CCL2, TNF, IL10
20polymyxin b449.1IL10, TNF, CCL2
21groalpha449.1IL10, TNF, CCL2
228-isoprostane449.1IL10, TNF, CCL2
23tarc449.1CCL2, TNF, IL10
24ccl344 2810.1IL10, TNF, CCL2
25sp 60012544 5910.0TNF, TNFRSF1A, CCL2
26thalidomide44 49 59 1112.0IL10, TNF, TNFRSF1A
27chloroquine44 2 49 28 1113.0TNFRSF1A, TNF, IL10
2815-deoxy-delta-12,14-prostaglandin j2449.0CCL2, TNF, IL10
29herbimycin a44 5910.0CCL2, TNFRSF1A, TNF, LTA
30okt3448.9TNFRSF1A, TNF, LTA, IL10
31paraffin448.9CCL2, TNFRSF1A, HLA-DQA1, LTA, IL10
32etanercept44 49 1110.9TNFRSF1A, TNF, LTA, IL10
33infliximab44 49 1110.9TNFRSF1A, TNF, LTA, IL10
34neopterin448.9IL10, LTA, TNF, TNFRSF1A
35ionomycin448.9TNFRSF1A, TNF, LTA, IL10
36toxin-1448.9IL10, LTA, TNF, CCL2
37lipoteichoic acid448.8CCL2, TNF, LTA, IL10
38il 10448.8IL10, LTA, TNF, CCL2
39calcitriol44 59 11 2411.8TNFRSF1A, TNF, LTA, IL10
40simvastatin44 49 59 28 11 2413.8CCL2, TNFRSF1A, TNF, IL10
41actinomycin d448.8CCL2, TNFRSF1A, TNF, LTA
42prostacyclin448.8CCL2, TNFRSF1A, TNF, IL10
43atorvastatin44 49 28 11 2412.7IL10, TNF, CCL2
44sb 20358044 599.7CCL2, TNFRSF1A, TNF, IL10
45oxygen44 249.7CCL2, TNFRSF1A, TNF, TYRP1
46methotrexate44 49 1110.5TNFRSF1A, TNF, HLA-DRB1, IL10
47tgf beta1448.5IL10, LTA, TNF, TNFRSF1A, CCL2
48vegf448.3CCL2, TNFRSF1A, TNF, LTA, IL10
49nitric oxide44 11 2410.3CCL2, TNFRSF1A, TNF, LTA, IL10
50serine447.9CCL2, TNFRSF1A, TNF, CRYAA, LTA, TYRP1

GO Terms for genes affiliated with Sympathetic Ophthalmia

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16Gene Ontology
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Cellular components related to Sympathetic Ophthalmia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.5HLA-DQA1, HLA-DRB1
2clathrin-coated endocytic vesicle membraneGO:0306699.3HLA-DRB1, TYRP1, HLA-DQA1
3integral to lumenal side of endoplasmic reticulum membraneGO:0715569.1HLA-C, HLA-DRB1, HLA-DQA1
4ER to Golgi transport vesicle membraneGO:0125079.1HLA-DRB1, HLA-C, HLA-DQA1
5Golgi membraneGO:0001398.6TNFRSF1A, HLA-DQA1, HLA-DRB1, HLA-C
6extracellular spaceGO:0056158.1CCL2, TNF, LTA, IL10, TNFRSF1A
7integral to plasma membraneGO:0058877.6TNFRSF1A, HLA-DQA1, HLA-DRB1, HLA-C, TNF

Biological processes related to Sympathetic Ophthalmia according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1response to amino acid stimulusGO:0432009.9TNFRSF1A, CCL2
2cellular response to estradiol stimulusGO:0713929.8TNFRSF1A, IL10
3positive regulation of chronic inflammatory response to antigenic stimulusGO:0028769.7LTA, TNF
4positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.6LTA, TNF
5negative regulation of interferon-gamma productionGO:0326899.5IL10, HLA-DRB1
6positive regulation of synaptic transmissionGO:0508069.5TNF, CCL2
7receptor biosynthetic processGO:0328009.4TNF, IL10
8negative regulation of cytokine secretion involved in immune responseGO:0027409.4TNF, IL10
9interferon-gamma-mediated signaling pathwayGO:0603339.3HLA-DQA1, HLA-DRB1, HLA-C
10lipopolysaccharide-mediated signaling pathwayGO:0316639.3CCL2, TNF
11extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.3TNFRSF1A, TNF
12positive regulation of cytokine secretionGO:0507159.2IL10, TNF
13protein kinase B signaling cascadeGO:0434919.2TNF, CCL2
14humoral immune responseGO:0069599.2LTA, TNF, CCL2
15negative regulation of T cell proliferationGO:0421309.2IL10, HLA-DRB1
16negative regulation of growth of symbiont in hostGO:0441309.2IL10, LTA, TNF
17negative regulation of interleukin-6 productionGO:0327159.1IL10, TNF, TNFRSF1A
18negative regulation of gene expressionGO:0106299.1CRYAA, TNF, TNFRSF1A
19response to activityGO:0148239.1CCL2, TNF, IL10
20cellular response to organic cyclic compoundGO:0714078.9TNF, CCL2
21inflammatory responseGO:0069548.6CCL2, TNFRSF1A, TNF, IL10
22cytokine-mediated signaling pathwayGO:0192218.6CCL2, TNFRSF1A, HLA-C, HLA-DRB1, HLA-DQA1
23response to glucocorticoid stimulusGO:0513848.6IL10, CRYAA, TNF, CCL2
24response to hypoxiaGO:0016668.4LTA, CRYAA, TNF, TNFRSF1A, CCL2
25response to drugGO:0424938.2CCL2, TNF, CRYAA, LTA, IL10

Molecular functions related to Sympathetic Ophthalmia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.5HLA-DQA1, HLA-DRB1
2peptide antigen bindingGO:0426059.4HLA-DRB1, HLA-C
3tumor necrosis factor receptor bindingGO:0051649.0LTA, TNF
4cytokine activityGO:0051258.7IL10, LTA, TNF

Products for genes affiliated with Sympathetic Ophthalmia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sympathetic Ophthalmia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet