MCID: SYM002
MIFTS: 41

Sympathetic Ophthalmia malady

Categories: Eye diseases, Rare diseases, Immune diseases

Aliases & Classifications for Sympathetic Ophthalmia

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Sources:
11Disease Ontology, 13DISEASES, 52Orphanet, 37MeSH, 66UMLS, 28ICD10, 30ICD9CM, 67UMLS via Orphanet, 29ICD10 via Orphanet, 38MESH via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Sympathetic Ophthalmia:

Name: Sympathetic Ophthalmia 11 13 52
Ophthalmia, Sympathetic 37 66
 
Sympathetic Uveitis 11 52

Characteristics:

Orphanet epidemiological data:

52
sympathetic ophthalmia:
Inheritance: Not applicable; Age of onset: All ages

Classifications:

Orphanet: 52 
Rare eye diseases


External Ids:

Disease Ontology11 DOID:12029
ICD1028 H44.13
ICD9CM30 360.11
MeSH37 D009879
SNOMED-CT60 75315001
Orphanet52 ORPHA79098
UMLS via Orphanet67 C0029077
ICD10 via Orphanet29 H44.1
MESH via Orphanet38 D009879

Summaries for Sympathetic Ophthalmia

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Wikipedia:69 Sympathetic ophthalmia (SO) or Sympathetic uveitis is a bilateral diffuse granulomatous uveitis (a kind... more...

MalaCards based summary: Sympathetic Ophthalmia, also known as ophthalmia, sympathetic, is related to burns and alopecia, and has symptoms including ciliary hyperaemia An important gene associated with Sympathetic Ophthalmia is CRYAA (Crystallin Alpha A), and among its related pathways are OX40 Pathway and African trypanosomiasis. Affiliated tissues include eye and retina.

Related Diseases for Sympathetic Ophthalmia

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Diseases related to Sympathetic Ophthalmia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1burns30.4IL10, TNF
2alopecia30.2IL10, TNF
3diphtheria29.9IL10, TNF
4conjunctival pigmentation29.4HLA-C, HLA-DRB1
5maligant granulosa cell tumor of ovary10.6LTA, TNF
6hemometra10.6LTA, TNF
7streptococcal meningitis10.6LTA, TNF
8common variable immunodeficiency10.6HLA-DRB1, TNF
9weber syndrome10.6HLA-DRB1, TNF
10rhizomelic pseudopolyarthritis10.6HLA-DRB1, TNF
11epstein-barr virus hepatitis10.6HLA-DRB1, TNF
12spondylohypoplasia, arthrogryposis and popliteal pterygium10.6LTA, TNF
13lymphocytic colitis10.6HLA-DRB1, TNF
14epididymis adenomatoid tumor10.6LTA, TNF
15spastic paraplegia-paget disease of bone syndrome10.6HLA-DRB1, TNF
16potato nose10.6HLA-DRB1, TNF
17keratomalacia10.5HLA-C, TNF
18fibrous histiocytoma10.5HLA-DRB1, TNF
19nephrosclerosis10.5HLA-DRB1, TNF
20chronic apical periodontitis10.5HLA-DRB1, TNF
21mitochondrial encephalomyopathy10.5HLA-C, HLA-DRB1
22antigen-peptide-transporter 2 deficiency10.5CTLA4, TNF
23foster-kennedy syndrome10.5HLA-C, HLA-DRB1
2412p12.1 microdeletion syndrome10.4IL10, TNF
25wolffian duct adenocarcinoma10.4HLA-DQA1, HLA-DRB1
26ampulla of vater neoplasm10.4HLA-DQA1, TNF
27autosomal recessive congenital methemoglobinemia10.4CTLA4, HLA-DRB1
28cutaneous porphyria10.4LTA, TNF
29peri-anal fistula10.4CTLA4, HLA-DRB1
30piepkorn karp hickok syndrome10.4IL10, TNF
316q terminal deletion syndrome10.4IL10, TNF
32autoinflammation, lipodystrophy, and dermatosis syndrome10.4HLA-DQA1, HLA-DRB1
33choroiditis10.4
34retinitis10.4
35basidiobolomycosis10.4IL10, TNF
36paralytic lagophthalmos10.4IL10, TNF
37hepatic coma10.4HLA-DRB1, TNF
38multiple carboxylase deficiency, propionic acidemia10.4IL10, TNF
39graft-versus-host disease, protection against10.4IL10, TNF
40duodenal benign neoplasm10.4HLA-DQA1, HLA-DRB1
41fallopian tube endometriosis10.4IL10, TNF
42isolated congenital auditory ossicle malformation10.4CTLA4, TNF
43oculogyric crisis10.4HLA-DQA1, HLA-DRB1
44ethmoid sinus adenoid cystic carcinoma10.4IL10, TNF
45addison's disease10.4IL10, TNF
46primary orthostatic tremor10.4IL10, TNF
47chromophil adenoma of the kidney10.4IL10, LTA
48multicentric castleman disease10.4HLA-DQA1, HLA-DRB1
49cirrhotic cardiomyopathy10.4HLA-C, HLA-DRB1
50papillary transitional carcinoma10.4IL10, TNF

Graphical network of the top 20 diseases related to Sympathetic Ophthalmia:



Diseases related to sympathetic ophthalmia

Symptoms for Sympathetic Ophthalmia

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UMLS symptoms related to Sympathetic Ophthalmia:


ciliary hyperaemia

Drugs & Therapeutics for Sympathetic Ophthalmia

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Drugs for Sympathetic Ophthalmia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1triamcinolone acetonidePhase 1, Phase 2463
2
TriamcinolonePhase 1, Phase 2463124-94-731307
Synonyms:
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione
11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione
124-94-7
4-08-00-03629 (Beilstein Handbook Reference)
83474-03-7
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-16-alpha-hydroxyprednisolone
9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy
9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-hydroxyprednisolone
9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-16α-hydroxyprednisolone
AC-2072
AC1L1LDH
AC1Q5HJC
Adcortyl
Aristocort
Aristocort A
Aristocort Tablets
Aristogel
Aristospan
Azmacort
BPBio1_000154
BRD-K77554836-001-03-3
BRN 2341955
BSPBio_000140
Bio-0662
C21H27FO6
CHEMBL1451
CID31307
CL 19823
Celeste
Cinolone
Cinolone-T
D00385
D014221
DB00620
Delphicort
EINECS 204-718-7
EU-0101179
Fluoxiprednisolone
Fluoxyprednisolone
Flutex
Fougera
HMS1568G22
HMS2090D12
HSDB 3194
Kenacort
Kenacort (TN)
Kenacort-A
Kenacort-AG
Kenacort-Ag
Kenalog
Kenalog in Orabase
Kenalog-10
Kenalog-40
Kenalog-H
LS-698
Ledercort
Lopac0_001179
 
MLS000028542
MLS001066543
MLS002695935
MolPort-002-528-981
Mycolog
NCGC00021580-03
NCGC00021580-04
NCGC00021580-05
NCGC00021580-06
NCGC00021580-07
NCI60_000750
NSC 13397
NSC13397
Nasacort
Nasacort Aq
Nasacort Hfa
Omcilon
Omicilon
Oracort
Oralone
Orion
Polcortolon
Pregna-1,4-diene-3,20-dio
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)
Prestwick0_000120
Prestwick1_000120
Prestwick2_000120
Prestwick3_000120
Prestwick_438
Rodinolone
S1933_Selleck
SK-Triamcinolone
SMP1_000300
SMR000058333
SPBio_002079
Sk-Triamcinolone
T6376_SIGMA
TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))
Tiamcinolonum
Tiamcinolonum [INN-Latin]
Tri-Nasal
Triacet
Triacort
Triam-Tablinen
Triamcet
Triamcinalone
Triamcinlon
Triamcinolon
Triamcinolona
Triamcinolona [INN-Spanish]
Triamcinolone (JP15/USP/INN)
Triamcinolone [USAN:INN:BAN:JAN]
Triamcinolone acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Triamcinolonum
Triamcinolonum [INN]
Triatex
Tricortale
Triderm
Trilone
Tristoject
Trymex
UNII-1ZK20VI6TY
Vetalog
Volon
Volon A
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ
ZINC03882036
droxypregna-1,4-diene-3,20-dione
ione
nchembio.2007.53-comp7
triamcinolone
3glucocorticoidsPhase 1, Phase 24756

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat UveitisCompletedNCT01789320Phase 1, Phase 2
2Safety and Efficacy of AIN457 in Noninfectious UveitisCompletedNCT00685399Phase 2
3Safety Study of Conventional Versus Micropulse Transscleral Cyclophotocoagulation in Treating End-Stage GlaucomaRecruitingNCT00349414Phase 1, Phase 2
4Adjunctive Photodynamic Therapy + Aflibercept vs. Afilbercept Alone for PDA in NV AMDWithdrawnNCT02457026

Search NIH Clinical Center for Sympathetic Ophthalmia


Cochrane evidence based reviews: ophthalmia, sympathetic

Genetic Tests for Sympathetic Ophthalmia

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Anatomical Context for Sympathetic Ophthalmia

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MalaCards organs/tissues related to Sympathetic Ophthalmia:

34
Eye, Retina

Animal Models for Sympathetic Ophthalmia or affiliated genes

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Publications for Sympathetic Ophthalmia

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Articles related to Sympathetic Ophthalmia:

(show top 50)    (show all 319)
idTitleAuthorsYear
1
Bilateral hearing impairment as the initial symptom of sympathetic ophthalmia. (25720920)
2015
2
SYMPATHETIC OPHTHALMIA: Clinicopathologic Correlation in a Consecutive Case Series. (25719985)
2015
3
A case of sympathetic ophthalmia after 23-gauge transconjunctival sutureless vitrectomy. (26028951)
2015
4
Presumed sympathetic ophthalmia after scleral buckling surgery. (25383825)
2013
5
Sympathetic Ophthalmia in Pediatric Age Group: Clinical Features and Challenges in Management in a Tertiary Center in Southern India. (24131076)
2013
6
Sympathetic ophthalmia: enucleation or evisceration? (21876595)
2011
7
A case of sympathetic ophthalmia after a severe acanthamoeba keratitis. (21471815)
2011
8
A case of sympathetic ophthalmia presenting with extraocular symptoms and conjunctival pigmentation after repeated 23-gauge vitrectomy. (20662657)
2010
9
Sympathetic ophthalmia manifesting with conjunctival chemosis. (19957100)
2010
10
Subretinal hypopyon in sympathetic ophthalmia. (19412871)
2009
11
Management of sympathetic ophthalmia with the fluocinolone acetonide implant. (19147232)
2009
12
Sir William Mackenzie: sympathetic ophthalmia and glaucoma before ophthalmoscopy. (20002997)
2009
13
Unusual Presentation of Sympathetic Ophthalmia. (19928706)
2009
14
Recurrent neovascularization of the disc in sympathetic ophthalmia. (18417828)
2008
15
Sympathetic ophthalmia in Singapore: new trends in an old disease. (16028023)
2006
16
Sympathetic ophthalmia following postoperative bacterial endophthalmitis: a clinicopathologic study. (16490496)
2006
17
Bilateral exudative retinal detachments as initial presentation of sympathetic ophthalmia in Turner syndrome. (16883368)
2006
18
Intravitreal triamcinolone acetonide in sympathetic ophthalmia. (15756580)
2005
19
Immunopathology of progressive subretinal fibrosis: a variant of sympathetic ophthalmia. (15364234)
2004
20
Sympathetic ophthalmia after three pars plana vitrectomies without prior ocular injury. (10950423)
2000
21
Sympathetic ophthalmia: an autoimmune ocular inflammatory disease. (10457586)
1999
22
Chlorambucil therapy in sympathetic ophthalmia. (7709973)
1995
23
Sympathetic ophthalmia. (10155637)
1994
24
Successfully treated sympathetic ophthalmia with typical histological confirmation. (8485440)
1993
25
Sympathetic ophthalmia: visual results with modern immunosuppressive therapy. (1286704)
1992
26
Surgical treatment of sympathetic ophthalmia. (1794786)
1991
27
Sympathetic ophthalmia and subretinal neovascularization. (2369029)
1990
28
Does Nd:YAG cyclotherapy cause sympathetic ophthalmia? (2779961)
1989
29
Histologic and immunopathologic findings in sympathetic ophthalmia. (3994570)
1985
30
Sympathetic ophthalmia simulating vogt-Koyanagi-Harada's disease: a clinico-pathologic study of four cases. (6656012)
1983
31
Atypical histopathologic features in sympathetic ophthalmia. A study of a hundred cases. (7068330)
1982
32
Sixty-five years of sympathetic ophthalmia. A clinicopathologic review of 105 cases (1913--1978). (7383540)
1980
33
Histologic variations related to race in sympathetic ophthalmia. (4440728)
1974
34
Sympathetic ophthalmia in Canada. (4274314)
1972
35
Sympathetic ophthalmia after couching operation. (4668490)
1972
36
Lymphocyte-stimulating activity of ocular tissues in sympathetic ophthalmia. (5124018)
1971
37
Observations on sympathetic ophthalmia. (5904961)
1966
38
SYMPATHETIC OPHTHALMIA AFTER EVISCERATION. (14167188)
1964
39
Frequency of sympathetic ophthalmia in different parts of the world. (13702350)
1961
40
Sympathetic Ophthalmia: A Case Treated by Prolonged Use of Corticotropin and Adrenal Steroids. (16693596)
1960
41
Sympathetic ophthalmia. (14427949)
1960
42
Sympathetic ophthalmia controlled by continuous cortisone therapy over a four-year period. (13458314)
1957
43
The Vogt-Koyanagi syndrome: a variant of sympathetic ophthalmia; report of two cases. (13402850)
1957
44
Sympathetic ophthalmia treated successfully with ACTH. (14839591)
1951
45
Sympathetic ophthalmia or phacoanaphylaxis? (18874349)
1948
46
Panophthalmitis and Sympathetic Ophthalmia. (16693167)
1938
47
NOTE ON THE BLOOD IN SYMPATHETIC OPHTHALMIA. (20765685)
1911
48
SYMPATHETIC OPHTHALMIA. (20757901)
1898
49
A Case of traumatic dislocation of the Iris under the unbroken conjunctiva - eye damaged but preserved, Typical sympathetic ophthalmia in the other eye. (16691866)
1893
50
Manchester Eye Hospital: Sympathetic Ophthalmia - Complete Loss of Vision-Restoration of Sight by Operative Means. (21373119)
1842

Variations for Sympathetic Ophthalmia

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Expression for genes affiliated with Sympathetic Ophthalmia

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Search GEO for disease gene expression data for Sympathetic Ophthalmia.

Pathways for genes affiliated with Sympathetic Ophthalmia

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Pathways related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 25)
idSuper pathwaysScoreTop Affiliating Genes
19.6IL10, LTA
29.3IL10, TNF
39.3IL10, TNF
4
Show member pathways
9.3IL10, TNF
59.1HLA-C, HLA-DQA1, HLA-DRB1
69.0HLA-DQA1, HLA-DRB1, IL10
7
Show member pathways
9.0IL10, LTA, TNF
89.0IL10, LTA, TNF
99.0IL10, LTA, TNF
108.9HLA-DRB1, IL10, TNF
11
Show member pathways
8.7CTLA4, HLA-DQA1, HLA-DRB1
12
Show member pathways
8.7CTLA4, HLA-DQA1, HLA-DRB1
138.7CTLA4, HLA-DQA1, HLA-DRB1
148.6HLA-C, HLA-DQA1, HLA-DRB1, IL10
15
Show member pathways
8.5HLA-C, HLA-DQA1, LTA, TNF
16
Show member pathways
8.5HLA-C, IL10, LTA, TNF
178.4HLA-DQA1, HLA-DRB1, IL10, TNF
18
Show member pathways
8.4HLA-DQA1, HLA-DRB1, IL10, TNF
19
Show member pathways
8.4HLA-DQA1, HLA-DRB1, IL10, TNF
208.3CTLA4, HLA-C, HLA-DQA1, HLA-DRB1
218.1CTLA4, IL10, LTA, TNF
228.1CTLA4, HLA-DQA1, HLA-DRB1, TNF
238.1HLA-C, HLA-DQA1, HLA-DRB1, LTA, TNF
24
Show member pathways
8.1HLA-C, HLA-DQA1, HLA-DRB1, LTA, TNF
25
Show member pathways
6.7CTLA4, HLA-C, HLA-DQA1, HLA-DRB1, IL10, LTA

GO Terms for genes affiliated with Sympathetic Ophthalmia

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Cellular components related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.8HLA-DQA1, HLA-DRB1
2clathrin-coated endocytic vesicle membraneGO:00306699.7HLA-DQA1, HLA-DRB1
3transport vesicle membraneGO:00306589.5HLA-DQA1, HLA-DRB1
4integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.4HLA-C, HLA-DQA1, HLA-DRB1
5ER to Golgi transport vesicle membraneGO:00125079.1HLA-C, HLA-DQA1, HLA-DRB1

Biological processes related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chronic inflammatory response to antigenic stimulusGO:000287610.0LTA, TNF
2positive regulation of humoral immune response mediated by circulating immunoglobulinGO:000292510.0LTA, TNF
3positive regulation of interferon-gamma productionGO:00327299.8LTA, TNF
4receptor biosynthetic processGO:00328009.8IL10, TNF
5negative regulation of cytokine secretion involved in immune responseGO:00027409.8IL10, TNF
6positive regulation of cytokine secretionGO:00507159.5IL10, TNF
7negative regulation of interleukin-6 productionGO:00327159.5IL10, TNF
8interferon-gamma-mediated signaling pathwayGO:00603339.4HLA-C, HLA-DQA1, HLA-DRB1
9negative regulation of B cell proliferationGO:00308899.2CTLA4, IL10
10negative regulation of growth of symbiont in hostGO:00441308.9IL10, LTA, TNF
11negative regulation of T cell proliferationGO:00421308.8CTLA4, IL10
12T cell costimulationGO:00312958.7CTLA4, HLA-DQA1, HLA-DRB1

Molecular functions related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00051649.8LTA, TNF
2peptide antigen bindingGO:00426059.1HLA-C, HLA-DQA1, HLA-DRB1
3cytokine activityGO:00051258.7IL10, LTA, TNF

Sources for Sympathetic Ophthalmia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet