MCID: SYM002
MIFTS: 45

Sympathetic Ophthalmia malady

Eye category

Summaries for Sympathetic Ophthalmia

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Sympathetic ophthalmia (SO) is a bilateral diffuse granulomatous uveitis (a kind of inflammation) of... more...

MalaCards: Sympathetic Ophthalmia, also known as sympathetic uveitis, is related to vogt-koyanagi-harada disease and blindness. An important gene associated with Sympathetic Ophthalmia is TYRP1 (tyrosinase-related protein 1), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The compounds endotoxin and ivig have been mentioned in the context of this disorder. Affiliated tissues include retina and b cells, and related mouse phenotypes are vision/eye and skeleton.

Aliases & Classifications for Sympathetic Ophthalmia

Sources:
8Disease Ontology, 49Orphanet, 61UMLS, 35MeSH, 27ICD9CM, 57SNOMED-CT, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Characteristics (Orphanet epidemiological data):

49
sympathetic ophthalmia:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Variable


Aliases & Descriptions:

sympathetic ophthalmia 8 49
sympathetic uveitis 8 49
ophthalmia, sympathetic 61


External Ids:

Disease Ontology8 DOID:12029
MeSH35 D009879
ICD9CM27 360.11
MESH via Orphanet36 D009879
SNOMED-CT57 75315001
ICD10 via Orphanet26 H44.1
SNOMED-CT via Orphanet58 75315001
UMLS via Orphanet62 C0029077

Related Diseases for Sympathetic Ophthalmia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Sympathetic Ophthalmia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1vogt-koyanagi-harada disease30.8HLA-DRB1
2blindness30.2CRYAA
3vasculitis30.2CCL2, TNF
4behcet's disease30.2TNF, LTA, HLA-C
5uveitis30.2IL10, LTA, CCL2, TNFRSF1A, TNF, HLA-C
6neovascular glaucoma10.3
7retinal perforation10.3
8choroiditis10.2
9diphtheria10.2
10conjunctival pigmentation10.2
11panophthalmitis10.2
12alopecia10.2
13turner syndrome10.2
14acanthamoeba keratitis10.2
15vitiligo10.0TYRP1
16hypothyroidism10.0TYRP1
17optic neuritis10.0LTA
18influenza10.0LTA
19coronary heart disease10.0LTA
20neutropenia10.0TNFRSF1A
21duodenal ulcer10.0LTA
22celiac disease10.0HLA-DQA1
23cholera10.0TYRP1
24dengue hemorrhagic fever10.0LTA
25kawasaki disease10.0CCL2
26proliferative diabetic retinopathy10.0CCL2
27endometriosis10.0CCL2
28glomerulonephritis10.0CCL2
29hepatitis10.0LTA
30cystic fibrosis10.0HLA-DQA1
31tonsillitis10.0LTA
32myeloid leukemia10.0LTA
33eye disease10.0CCL2
34astrocytoma10.0LTA
35encephalitis10.0CCL2
36hypertension10.0CCL2
37pulmonary fibrosis10.0CCL2
38pulmonary alveolar proteinosis10.0CCL2
39cervical cancer10.0HLA-C
40osteosarcoma10.0TNFRSF1A
41human immunodeficiency virus infectious disease10.0HLA-C
42schistosomiasis10.0IL10
43stevens-johnson syndrome10.0HLA-C
44allergic rhinitis10.0IL10
45pancreatitis10.0IL10
46leprosy10.0HLA-DRB1
47periapical granuloma10.0CCL2
48anaplastic large cell lymphoma10.0TNFRSF1A
49narcolepsy10.0HLA-DRB1
50pemphigus foliaceus10.0HLA-DRB1

Graphical network of the top 20 diseases related to Sympathetic Ophthalmia:



Diseases related to sympathetic ophthalmia

Clinical Features for Sympathetic Ophthalmia

Drugs & Therapeutics for Sympathetic Ophthalmia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Sympathetic Ophthalmia

Drug clinical trials:

Search ClinicalTrials for Sympathetic Ophthalmia

Search NIH Clinical Center for Sympathetic Ophthalmia

Search CenterWatch for Sympathetic Ophthalmia

Genetic Tests for Sympathetic Ophthalmia

Anatomical Context for Sympathetic Ophthalmia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Sympathetic Ophthalmia:

33
Retina, B cells

Animal Models for Sympathetic Ophthalmia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Sympathetic Ophthalmia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.7TYRP1, CRYAA
2MP:00053909.5TYRP1, LTA, TNFRSF1A
3MP:00020068.0CCL2, TNFRSF1A, TNF, TYRP1, IL10
4MP:00053707.8CCL2, TNFRSF1A, TNF, LTA, IL10
5MP:00053977.7IL10, LTA, HLA-DQA1, TNF, TNFRSF1A, CCL2

Publications for Sympathetic Ophthalmia

Sources:
51PubMed
See all sources

Articles related to Sympathetic Ophthalmia:

(show top 50)    (show all 297)
idTitleAuthorsYear
1
Immunopathologic processes in sympathetic ophthalmia as signified by microRNA profiling. (22589448)
2012
2
The role of perivascular melanophage infiltrates in the conjunctiva in sympathetic ophthalmia. (21595534)
2011
3
Management and clinical outcome of penetrating keratoplasty for long-term corneal changes in sympathetic ophthalmia. (21772984)
2011
4
Imaging of Dalen-Fuchs Nodules in a Likely Case of Sympathetic Ophthalmia by Fluorescein Angiography and OCT. (20337315)
2010
5
Development of sympathetic ophthalmia following globe injury. (20137482)
2009
6
Management of sympathetic ophthalmia with the fluocinolone acetonide implant. (19147232)
2009
7
Unusual Presentation of Sympathetic Ophthalmia. (19928706)
2009
8
Sympathetic ophthalmia. (18795315)
2009
9
Penetrating keratoplasty for the exciting eye in sympathetic ophthalmia. (18812778)
2008
10
Sympathetic ophthalmia following vitrectomy for endophthalmitis after intravitreal bevacizumab. (19065420)
2008
11
Sympathetic ophthalmia following severe fungal keratitis. (16691261)
2006
12
Sympathetic ophthalmia after successful retinal reattachment surgery with vitrectomy. (17191203)
2006
13
Indocyanine green angiography findings in sympathetic ophthalmia. (15792321)
2005
14
Sir Frederick Treves and sympathetic ophthalmia. (14718303)
2004
15
Successful treatment of rhegmatogenous retinal detachment secondary to globe perforation during peribulbar injection in a case of sympathetic ophthalmia. (15497554)
2004
16
Sympathetic ophthalmia and indocyanine green angiography. (15477482)
2004
17
Experimental studies of melanin associated antigen and its relationship with sympathetic ophthalmia and Vogt-Kayanagi-Harada syndrome. (14574978)
2003
18
Central serous retinopathy masquerading as sympathetic ophthalmia. (12855987)
2003
19
Sympathetic ophthalmia: an autoimmune ocular inflammatory disease. (10457586)
1999
20
Mechanisms of inflammatory response in sympathetic ophthalmia and VKH syndrome. (9349415)
1997
21
Sympathetic ophthalmia: an immunohistochemistry study of four cases. (8741154)
1996
22
Sympathetic ophthalmia after cyclocryotherapy of neovascular glaucoma without ocular penetration. (8446333)
1993
23
Sympathetic ophthalmia: visual results with modern immunosuppressive therapy. (1286704)
1992
24
Sympathetic ophthalmia, a genuine autoimmune disease. (2200640)
1990
25
Sympathetic ophthalmia following Nd:YAG cyclotherapy. (2250864)
1990
26
High-dose short-term chlorambucil for intractable sympathetic ophthalmia and BehAset's disease. (2378842)
1990
27
Necrotic changes of choroidal melanocytes in sympathetic ophthalmia. (3341981)
1988
28
Relationship between sympathetic ophthalmia, phacoanaphylatic endophthalmitis, and Vogt-Koyanagi-Harada disease. (3050697)
1988
29
Delayed onset sympathetic ophthalmia. (3670198)
1987
30
Sympathetic ophthalmia. (3502740)
1987
31
Histocompatibility antigens in sympathetic ophthalmia. (6742071)
1984
32
Human sympathetic ophthalmia. An analysis of the inflammatory infiltrate by hybridoma-monoclonal antibodies, immunochemistry, and correlative electron microscopy. (6338439)
1983
33
Sympathetic ophthalmia: a comparison of the histopathological features from a Chinese and American series. (7107131)
1982
34
Sympathetic ophthalmia. (7315933)
1981
35
Recent advances in sympathetic ophthalmia. (396680)
1979
36
Sympathetic ophthalmia. A long-term follow-up. (629672)
1978
37
Rhegmatogenous retinal detachment in Coats' syndrome and in sympathetic ophthalmia. (5056338)
1972
38
Lymphocyte-stimulating activity of ocular tissues in sympathetic ophthalmia. (5124018)
1971
39
Observations on sympathetic ophthalmia. (5904961)
1966
40
Sympathetic ophthalmia cured by cortisone and ACTH. (13317956)
1956
41
Sympathetic ophthalmia following an operation for retinal detachment. (13115609)
1953
42
Sympathetic ophthalmia, its pathogenesis and prophylaxis. (14890898)
1951
43
Sympathetic ophthalmia treated successfully with ACTH. (14839591)
1951
44
Malignant melanoma of the choroid with sympathetic ophthalmia. (18132900)
1949
45
Experimental studies on sympathetic ophthalmia. (15399172)
1949
46
Clinical aspects of sympathetic ophthalmia. (18874350)
1948
47
Analysis of the Proliferative and Exudative Elements in Some Cases of Sympathetic Ophthalmia. (16692894)
1931
48
A Case of Late Sympathetic Ophthalmia. (19983977)
1924
49
SYMPATHETIC OPHTHALMIA. (20757901)
1898
50
Clinical History of a Case of Sympathetic Ophthalmia. (16691778)
1884

Genetic Variations for Sympathetic Ophthalmia

Expression for genes affiliated with Sympathetic Ophthalmia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Sympathetic Ophthalmia

Search GEO for disease gene expression data for Sympathetic Ophthalmia.

Pathways for genes affiliated with Sympathetic Ophthalmia

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 53R&D Systems, 56SinoBiological
See all sources

Pathways related to Sympathetic Ophthalmia according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2LTA
2
Hide members
10.1TNFRSF1A
39.9HLA-DRB1
4
Hide members
9.8TNFRSF1A, LTA
59.6IL10, LTA
6
Hide members
9.5HLA-DRB1, HLA-DQA1
79.3TNFRSF1A, TNF
8
Hide members
9.3TNFRSF1A, TNF
99.3TNFRSF1A, HLA-C, HLA-DQA1
109.2CCL2, TNF
119.0HLA-DQA1, HLA-DRB1, HLA-C
129.0HLA-C, HLA-DRB1, HLA-DQA1
139.0TNFRSF1A, LTA, TNF
14
Hide members
9.0TNFRSF1A, TNF, LTA
15
Hide members
9.0TNF, TNFRSF1A, LTA
16
Hide members
9.0TNFRSF1A, LTA, TNF
17
Hide members
9.0TNFRSF1A, TNF, LTA
18
Hide members
9.0LTA, TNF, TNFRSF1A
19
Hide members
9.0TNF, LTA, TNFRSF1A
209.0LTA, TNFRSF1A, TNF
21
Hide members
9.0TNF, LTA, TNFRSF1A
229.0IL10, HLA-DRB1, HLA-DQA1
23
Hide members
8.8LTA, IL10, TNF
248.8IL10, LTA, TNF
25
Hide members
8.8IL10, TNF, TNFRSF1A
26
Development PDGF signaling via STATs and NF-kB
Hide members
8.7IL10, TNF, CCL2
27
Hide members
8.6CCL2, LTA, TNF, TNFRSF1A
288.6TNF, LTA, TNFRSF1A, CCL2
298.5HLA-DQA1, IL10, HLA-C, HLA-DRB1
30
Hide members
8.4TNF, CCL2, TNFRSF1A, IL10
31
Hide members
8.3TNFRSF1A, TNF, HLA-DRB1, HLA-DQA1
32
Hide members
8.2LTA, HLA-C, TNF, TNFRSF1A, HLA-DQA1
33
Hide members
8.1HLA-DQA1, HLA-DRB1, TNF, IL10
34
Hide members
8.1CCL2, TNFRSF1A, LTA, TNF, IL10
35
Hide members
8.1TNFRSF1A, CCL2, LTA, IL10, TNF
367.8IL10, TNFRSF1A, TNF, HLA-DQA1, HLA-DRB1
37
Hide members
7.1CCL2, TNFRSF1A, LTA, HLA-DQA1, HLA-DRB1, HLA-C
38
Hide members
7.0TNFRSF1A, TNF, HLA-C, HLA-DRB1, HLA-DQA1, LTA

Compounds for genes affiliated with Sympathetic Ophthalmia

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB, 24HMDB
See all sources

Compounds related to Sympathetic Ophthalmia according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1endotoxin4510.6TNFRSF1A
2ivig4510.6TNFRSF1A
3cycloheximide4510.5LTA
4pentoxifylline45 1111.5LTA
5dexamethasone45 50 29 1113.5LTA
6cyclosporin a45 29 6012.3LTA
7bcma4510.1TNFRSF1A
8aspartate459.9CRYAA, CCL2
9prednisolone45 29 1111.9LTA
10dpa 1459.8HLA-DRB1, HLA-DQA1
11gm-csf45 2910.5TNF, IL10
12cdp571459.4IL10, TNF
13rantes459.4TNF, LTA, TNFRSF1A
14interferon gamma459.4TNF, IL10
15blys459.2TNFRSF1A, IL10, TNF
16n-tosyl-l-phenylalanine chloromethyl ketone459.1TNF, CCL2
17mip 1alpha459.1CCL2, TNF, IL10
185 aminosalicylic acid459.1IL10, TNF, CCL2
19il-12459.1TNF, CCL2, IL10
20polymyxin b459.1IL10, TNF, CCL2
21groalpha459.1CCL2, IL10, TNF
228-isoprostane459.1CCL2, IL10, TNF
23tarc459.1IL10, TNF, CCL2
24ccl345 2910.1CCL2, TNF, IL10
25sp 60012545 6010.0TNFRSF1A, CCL2, TNF
26thalidomide45 50 60 1112.0IL10, TNF, TNFRSF1A
27chloroquine45 2 50 29 1113.0TNF, TNFRSF1A, IL10
2815-deoxy-delta-12,14-prostaglandin j2459.0IL10, CCL2, TNF
29herbimycin a45 6010.0LTA, TNF, CCL2, TNFRSF1A
30okt3458.9TNF, TNFRSF1A, IL10, LTA
31paraffin458.9CCL2, HLA-DQA1, LTA, IL10, TNFRSF1A
32etanercept45 50 1110.9TNF, IL10, LTA, TNFRSF1A
33infliximab45 50 1110.9TNFRSF1A, TNF, LTA, IL10
34neopterin458.9TNFRSF1A, TNF, LTA, IL10
35ionomycin458.9TNFRSF1A, TNF, LTA, IL10
36toxin-1458.9TNF, IL10, LTA, CCL2
37lipoteichoic acid458.8IL10, LTA, TNF, CCL2
38il 10458.8CCL2, TNF, LTA, IL10
39calcitriol45 60 11 2411.8IL10, TNF, TNFRSF1A, LTA
40simvastatin45 50 60 29 11 2413.8IL10, TNF, TNFRSF1A, CCL2
41actinomycin d458.8TNFRSF1A, TNF, LTA, CCL2
42prostacyclin458.8CCL2, TNFRSF1A, TNF, IL10
43atorvastatin45 50 29 11 2412.7IL10, TNF, CCL2
44sb 20358045 609.7IL10, TNF, TNFRSF1A, CCL2
45oxygen45 249.7TNFRSF1A, TYRP1, TNF, CCL2
46methotrexate45 50 1110.5TNF, IL10, TNFRSF1A, HLA-DRB1
47tgf beta1458.5IL10, CCL2, TNFRSF1A, TNF, LTA
48vegf458.3TNFRSF1A, CCL2, TNF, IL10, LTA
49nitric oxide45 11 2410.3IL10, LTA, TNF, CCL2, TNFRSF1A
50serine457.9TYRP1, CRYAA, TNF, TNFRSF1A, CCL2, LTA

GO Terms for genes affiliated with Sympathetic Ophthalmia

Sources:
16Gene Ontology
See all sources

Cellular components related to Sympathetic Ophthalmia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.5HLA-DQA1, HLA-DRB1
2clathrin-coated endocytic vesicle membraneGO:0306699.3HLA-DRB1, TYRP1, HLA-DQA1
3integral to lumenal side of endoplasmic reticulum membraneGO:0715569.1HLA-C, HLA-DRB1, HLA-DQA1
4ER to Golgi transport vesicle membraneGO:0125079.1HLA-DRB1, HLA-C, HLA-DQA1
5Golgi membraneGO:0001398.6TNFRSF1A, HLA-DQA1, HLA-DRB1, HLA-C
6extracellular spaceGO:0056158.1CCL2, TNF, LTA, IL10, TNFRSF1A
7integral to plasma membraneGO:0058877.6TNFRSF1A, HLA-DQA1, HLA-DRB1, HLA-C, TNF

Biological processes related to Sympathetic Ophthalmia according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1response to amino acid stimulusGO:0432009.8TNFRSF1A, CCL2
2cellular response to estradiol stimulusGO:0713929.8TNFRSF1A, IL10
3positive regulation of chronic inflammatory response to antigenic stimulusGO:0028769.7LTA, TNF
4positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.6LTA, TNF
5negative regulation of interferon-gamma productionGO:0326899.5HLA-DRB1, IL10
6positive regulation of synaptic transmissionGO:0508069.5TNF, CCL2
7receptor biosynthetic processGO:0328009.4IL10, TNF
8negative regulation of cytokine secretion involved in immune responseGO:0027409.4IL10, TNF
9interferon-gamma-mediated signaling pathwayGO:0603339.3HLA-C, HLA-DRB1, HLA-DQA1
10lipopolysaccharide-mediated signaling pathwayGO:0316639.3CCL2, TNF
11extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.3TNF, TNFRSF1A
12positive regulation of cytokine secretionGO:0507159.3TNF, IL10
13protein kinase B signaling cascadeGO:0434919.2CCL2, TNF
14humoral immune responseGO:0069599.2CCL2, LTA, TNF
15negative regulation of growth of symbiont in hostGO:0441309.2LTA, TNF, IL10
16cellular response to organic cyclic compoundGO:0714079.1TNF, CCL2
17negative regulation of interleukin-6 productionGO:0327159.1TNFRSF1A, IL10, TNF
18negative regulation of gene expressionGO:0106299.1CRYAA, TNFRSF1A, TNF
19response to activityGO:0148239.1IL10, TNF, CCL2
20negative regulation of T cell proliferationGO:0421309.0IL10, HLA-DRB1
21inflammatory responseGO:0069548.6TNFRSF1A, CCL2, TNF, IL10
22cytokine-mediated signaling pathwayGO:0192218.6CCL2, TNFRSF1A, HLA-C, HLA-DRB1, HLA-DQA1
23response to glucocorticoid stimulusGO:0513848.6TNF, CCL2, CRYAA, IL10
24response to hypoxiaGO:0016668.4LTA, CRYAA, TNF, TNFRSF1A, CCL2
25response to drugGO:0424938.2CCL2, TNF, CRYAA, LTA, IL10

Molecular functions related to Sympathetic Ophthalmia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.5HLA-DQA1, HLA-DRB1
2peptide antigen bindingGO:0426059.4HLA-DRB1, HLA-C
3tumor necrosis factor receptor bindingGO:0051649.0LTA, TNF
4cytokine activityGO:0051258.7IL10, LTA, TNF

Products for genes affiliated with Sympathetic Ophthalmia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sympathetic Ophthalmia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet