MCID: SYM002
MIFTS: 40

Sympathetic Ophthalmia malady

Categories: Eye diseases, Rare diseases, Immune diseases

Aliases & Classifications for Sympathetic Ophthalmia

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Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 40MESH via Orphanet, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Sympathetic Ophthalmia:

Name: Sympathetic Ophthalmia 11 54 13
Ophthalmia, Sympathetic 39 68
 
Sympathetic Uveitis 11 54

Characteristics:

Orphanet epidemiological data:

54
sympathetic ophthalmia:
Inheritance: Not applicable; Age of onset: All ages

Classifications:

Orphanet: 54 
Rare eye diseases


External Ids:

Disease Ontology11 DOID:12029
ICD1030 H44.13
ICD9CM32 360.11
MeSH39 D009879
SNOMED-CT62 75315001
Orphanet54 ORPHA79098
MESH via Orphanet40 D009879
UMLS via Orphanet69 C0029077
ICD10 via Orphanet31 H44.1

Summaries for Sympathetic Ophthalmia

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Wikipedia:71 Sympathetic ophthalmia (SO) or Sympathetic uveitis is a bilateral diffuse granulomatous uveitis (a kind... more...

MalaCards based summary: Sympathetic Ophthalmia, also known as ophthalmia, sympathetic, is related to chorioretinitis and choroiditis. An important gene associated with Sympathetic Ophthalmia is CRYAA (Crystallin Alpha A), and among its related pathways are Staphylococcus aureus infection and Transcription_NF-kB signaling pathway. Affiliated tissues include eye and retina.

Related Diseases for Sympathetic Ophthalmia

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Diseases related to Sympathetic Ophthalmia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1chorioretinitis29.8CTLA4, HLA-DRB1, TNF
2choroiditis10.3
3retinitis10.3
4spondylometaphyseal dysplasia east-african type10.2LTA, TNF
5thymic neuroendocrine carcinoma10.2LTA, TNF
6drug dependence10.2LTA, TNF
7idiopathic hypertrophic pachymeningitis10.2LTA, TNF
8vestibule of mouth cancer10.2LTA, TNF
9mirizzi syndrome10.2HLA-DRB1, TNF
10distal trisomy 14q10.2HLA-DRB1, TNF
11swine influenza10.2HLA-DRB1, TNF
12cauda equina syndrome10.2LTA, TNF
13human immunodeficiency virus infectious disease10.2HLA-DRB1, TNF
14childhood pleomorphic rhabdomyosarcoma10.2LTA, TNF
15endophthalmitis10.2
16primary ciliary dyskinesia10.2LTA, TNF
17clostridium difficile colitis10.2HLA-DRB1, TNF
18right ventricle hypoplasia10.2HLA-DRB1, TNF
19nystagmus, congenital motor, autosomal recessive10.2HLA-DRB1, TNF
20aseptic meningitis10.2HLA-DRB1, TNF
21pancreatic signet ring cell adenocarcinoma10.2HLA-DRB1, TNF
22orthostatic proteinuria10.2LTA, TNF
23cryptococcosis10.2HLA-DRB1, TNF
24chronic apical periodontitis10.2HLA-C, TNF
25congenital hypomyelination neuropathy10.2ITGA4, LTA
26cataract10.2
27retinal detachment10.2
28hereditary alpha tryptasemia syndrome10.2HLA-DRB1, TNF
29benign deep fibrous histiocytoma10.2HLA-DRB1, TNF
30cerebellar liponeurocytoma10.2ITGA4, TNF
31motility-related diarrhea10.2HLA-DRB1, TNF
32learning disability10.1HLA-C, HLA-DRB1
33endogenous depression10.1HLA-DRB1, TNF
34penis agenesis10.1HLA-DRB1, ITGA4
35plummer's disease10.1HLA-DRB1, TNF
36celiac disease 310.1CTLA4, HLA-DRB1
37complement component 8 deficiency10.1CTLA4, HLA-DRB1
38pseudohypoparathyroidism10.1HLA-C, HLA-DRB1
39patau syndrome10.1HLA-DRB1, TNF
40vogt-koyanagi-harada disease10.1
41melanoma10.1
42anaerobic meningitis10.1HLA-C, HLA-DRB1
43disease of mental health10.1HLA-DRB1, TNF
44orbital osteomyelitis10.1HLA-C, TNF
45abnormal retinal correspondence10.1CTLA4, TNF
46pulmonary hemosiderosis10.1HLA-DRB1, LTA, TNF
47deafness, autosomal recessive 6710.1HLA-DRB1, LTA, TNF
48atrial septal defect 610.1HLA-DRB1, LTA, TNF
49adnp syndrome10.1LTA, TNF
50immunoglobulin g deficiency10.0HLA-DRB1, TNF

Graphical network of the top 20 diseases related to Sympathetic Ophthalmia:



Diseases related to sympathetic ophthalmia

Symptoms & Phenotypes for Sympathetic Ophthalmia

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Drugs & Therapeutics for Sympathetic Ophthalmia

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Drugs for Sympathetic Ophthalmia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Triamcinoloneapproved, vet_approvedPhase 1, Phase 2510124-94-731307
Synonyms:
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione
11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione
124-94-7
4-08-00-03629 (Beilstein Handbook Reference)
83474-03-7
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-16-alpha-hydroxyprednisolone
9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy
9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-hydroxyprednisolone
9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-16α-hydroxyprednisolone
AC-2072
AC1L1LDH
AC1Q5HJC
Adcortyl
Aristocort
Aristocort A
Aristocort Tablets
Aristogel
Aristospan
Azmacort
BPBio1_000154
BRD-K77554836-001-03-3
BRN 2341955
BSPBio_000140
Bio-0662
C21H27FO6
CHEMBL1451
CID31307
CL 19823
Celeste
Cinolone
Cinolone-T
D00385
D014221
DB00620
Delphicort
EINECS 204-718-7
EU-0101179
Fluoxiprednisolone
Fluoxyprednisolone
Flutex
Fougera
HMS1568G22
HMS2090D12
HSDB 3194
Kenacort
Kenacort (TN)
Kenacort-A
Kenacort-AG
Kenacort-Ag
Kenalog
Kenalog in Orabase
Kenalog-10
Kenalog-40
Kenalog-H
LS-698
Ledercort
Lopac0_001179
 
MLS000028542
MLS001066543
MLS002695935
MolPort-002-528-981
Mycolog
NCGC00021580-03
NCGC00021580-04
NCGC00021580-05
NCGC00021580-06
NCGC00021580-07
NCI60_000750
NSC 13397
NSC13397
Nasacort
Nasacort Aq
Nasacort Hfa
Omcilon
Omicilon
Oracort
Oralone
Orion
Polcortolon
Pregna-1,4-diene-3,20-dio
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)
Prestwick0_000120
Prestwick1_000120
Prestwick2_000120
Prestwick3_000120
Prestwick_438
Rodinolone
S1933_Selleck
SK-Triamcinolone
SMP1_000300
SMR000058333
SPBio_002079
Sk-Triamcinolone
T6376_SIGMA
TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))
Tiamcinolonum
Tiamcinolonum [INN-Latin]
Tri-Nasal
Triacet
Triacort
Triam-Tablinen
Triamcet
Triamcinalone
Triamcinlon
Triamcinolon
Triamcinolona
Triamcinolona [INN-Spanish]
Triamcinolone (JP15/USP/INN)
Triamcinolone [USAN:INN:BAN:JAN]
Triamcinolone acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Triamcinolonum
Triamcinolonum [INN]
Triatex
Tricortale
Triderm
Trilone
Tristoject
Trymex
UNII-1ZK20VI6TY
Vetalog
Volon
Volon A
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ
ZINC03882036
droxypregna-1,4-diene-3,20-dione
ione
nchembio.2007.53-comp7
triamcinolone
2triamcinolone acetonidePhase 1, Phase 2510
3Triamcinolone diacetatePhase 1, Phase 2510
4Triamcinolone hexacetonidePhase 1, Phase 2510
5Immunosuppressive AgentsPhase 1, Phase 213086
6Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 1, Phase 213168
7glucocorticoidsPhase 1, Phase 25103
8Hormone AntagonistsPhase 1, Phase 213180
9HormonesPhase 1, Phase 214415
10Anti-Inflammatory AgentsPhase 1, Phase 210729

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety Study of Conventional Versus Micropulse Transscleral Cyclophotocoagulation in Treating End-Stage GlaucomaUnknown statusNCT00349414Phase 1, Phase 2
2Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat UveitisCompletedNCT01789320Phase 1, Phase 2
3Safety and Efficacy of AIN457 in Noninfectious UveitisCompletedNCT00685399Phase 2
4Adjunctive Photodynamic Therapy + Aflibercept vs. Afilbercept Alone for PDA in NV AMDWithdrawnNCT02457026

Search NIH Clinical Center for Sympathetic Ophthalmia


Cochrane evidence based reviews: ophthalmia, sympathetic

Genetic Tests for Sympathetic Ophthalmia

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Anatomical Context for Sympathetic Ophthalmia

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MalaCards organs/tissues related to Sympathetic Ophthalmia:

36
Eye, Retina

Publications for Sympathetic Ophthalmia

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Articles related to Sympathetic Ophthalmia:

(show top 50)    (show all 320)
idTitleAuthorsYear
1
A rare case of atypical sympathetic ophthalmia post therapeutic keratoplasty. (27638462)
2016
2
Multimodal Imaging in Sympathetic Ophthalmia. (27960610)
2016
3
Long-Term Drug-Free Remission and Visual Outcomes in Sympathetic Ophthalmia. (26808121)
2016
4
Sympathetic ophthalmia following a conjunctival flap procedure for corneal perforation. (26976837)
2016
5
AN ATYPICAL CASE OF SYMPATHETIC OPHTHALMIA AFTER LIMBAL CORNEAL LACERATION. (27124790)
2016
6
Characteristics of Sympathetic Ophthalmia in a Single International Center. (27651849)
2016
7
Sympathetic Ophthalmia after Ocular Wasp Sting. (26635462)
2015
8
SYMPATHETIC OPHTHALMIA: Clinicopathologic Correlation in a Consecutive Case Series. (25719985)
2015
9
Enhanced depth imaging OCT (EDI-OCT) findings in acute phase of sympathetic ophthalmia. (25772275)
2015
10
Bilateral hearing impairment as the initial symptom of sympathetic ophthalmia. (25720920)
2015
11
A case of sympathetic ophthalmia after 23-gauge transconjunctival sutureless vitrectomy. (26028951)
2015
12
Sympathetic ophthalmia caused by a severe ocular chemical burn: a case report and literature review. (25932266)
2015
13
Spontaneous dislocation of a fluocinolone acetonide implant (retisert) into the anterior chamber and its successful extraction in sympathetic ophthalmia. (25411930)
2015
14
Spectral-Domain Optical Coherence Tomography of Sympathetic Ophthalmia With Dalen-Fuchs Nodules. (25347826)
2014
15
Sympathetic ophthalmia after diode laser cyclophotocoagulation: now an issue in informed consent. (25103662)
2014
16
Sympathetic ophthalmia following diode laser cyclophotocoagulation. (24711656)
2014
17
Gender differences in vogt-koyanagi-harada disease and sympathetic ophthalmia. (24734166)
2014
18
Multiple serous retinal detachments seen on wide-field imaging in a patient with sympathetic ophthalmia. (25171189)
2014
19
Classical pathology of sympathetic ophthalmia presented in a unique case. (25067979)
2014
20
Long-term, drug-free remission of sympathetic ophthalmia with high-dose, short-term chlorambucil therapy. (24572676)
2014
21
Adalimumab for pediatric sympathetic ophthalmia. (25010359)
2014
22
Incidence of hypotony and sympathetic ophthalmia following trans-scleral cyclophotocoagulation for glaucoma and a report of risk factors. (23433313)
2013
23
Sympathetic Ophthalmia in Pediatric Age Group: Clinical Features and Challenges in Management in a Tertiary Center in Southern India. (24131076)
2013
24
Reversible alopecia in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia. (23514340)
2013
25
High definition spectral domain optical coherence tomography of retinal pigment epithelial rip in a case of sympathetic ophthalmia. (23514588)
2013
26
Sympathetic ophthalmia with sensorineural deafness - report of a case. (24225003)
2013
27
Sympathetic ophthalmia following enucleation. (22124788)
2013
28
Presumed sympathetic ophthalmia after scleral buckling surgery. (25383825)
2013
29
Sympathetic ophthalmia: to the twenty-first century and beyond. (23724856)
2013
30
Continued vision loss from progressive expansion of inactive chorioretinal scars in a myopic patient with well-controlled sympathetic ophthalmia. (25389936)
2012
31
Expression of I+-crystallin in the retina of human sympathetic ophthalmia. (22052021)
2012
32
Mitochondrial oxidative stress initiates visual loss in sympathetic ophthalmia. (22476625)
2012
33
Update on sympathetic ophthalmia. (22346110)
2012
34
Sympathetic ophthalmia: a review of literature. (22677732)
2012
35
Sympathetic ophthalmia in HIV infection. A clinicopathological case report. (22411458)
2012
36
Missed perforation presenting as sympathetic ophthalmia in an adolescent Malay girl. (22914237)
2012
37
Immunopathologic processes in sympathetic ophthalmia as signified by microRNA profiling. (22589448)
2012
38
Sympathetic ophthalmia after proton beam irradiation for choroA^dal melanoma. (22646709)
2012
39
Presumed occult globe rupture resulting in sympathetic ophthalmia. (22200914)
2012
40
Imaging for sympathetic ophthalmia: impact on the diagnosis and management. (22954939)
2012
41
Multimodality diagnostic imaging in a case of sympathetic ophthalmia. (22594960)
2012
42
Sympathetic ophthalmia. (21958181)
2011
43
Sympathetic ophthalmia: enucleation or evisceration? (21876595)
2011
44
A case of sympathetic ophthalmia after a severe acanthamoeba keratitis. (21471815)
2011
45
Reversible retinal changes in the acute stage of sympathetic ophthalmia seen on spectral domain optical coherence tomography. (21331811)
2011
46
Management and clinical outcome of penetrating keratoplasty for long-term corneal changes in sympathetic ophthalmia. (21772984)
2011
47
Efficacy of infliximab therapy in two patients with sympathetic ophthalmia. (21484652)
2011
48
Challenges of managing sympathetic ophthalmia in a young child and the role of infliximab. (21732578)
2011
49
Successful treatment of refractory sympathetic ophthalmia in a child with infliximab. (21320978)
2011
50
Sympathetic ophthalmia in an infected post-scleral buckling eye. (21603735)
2011

Variations for Sympathetic Ophthalmia

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Expression for genes affiliated with Sympathetic Ophthalmia

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Search GEO for disease gene expression data for Sympathetic Ophthalmia.

Pathways for genes affiliated with Sympathetic Ophthalmia

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Pathways related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 26)
idSuper pathwaysScoreTop Affiliating Genes
19.4HLA-DQA1, HLA-DRB1
29.3LTA, TNF
3
Show member pathways
9.3LTA, TNF
49.2HLA-DRB1, TNF
59.0HLA-C, HLA-DQA1, HLA-DRB1
6
Show member pathways
9.0HLA-C, HLA-DQA1, HLA-DRB1
79.0HLA-C, HLA-DQA1, HLA-DRB1
8
Show member pathways
8.9CTLA4, HLA-DQA1, HLA-DRB1
9
Show member pathways
8.9CTLA4, HLA-DQA1, HLA-DRB1
108.9CTLA4, HLA-DQA1, HLA-DRB1
11
Show member pathways
8.8HLA-C, LTA, TNF
128.8ITGA4, LTA, TNF
138.6HLA-DQA1, HLA-DRB1, TNF
14
Show member pathways
8.6HLA-DQA1, HLA-DRB1, TNF
15
Show member pathways
8.5HLA-C, HLA-DQA1, HLA-DRB1, ITGA4
168.2CTLA4, ITGA4, LTA, TNF
178.1CTLA4, HLA-DQA1, HLA-DRB1, TNF
18
Show member pathways
8.1HLA-DQA1, HLA-DRB1, ITGA4, TNF
198.1HLA-DQA1, HLA-DRB1, ITGA4, TNF
20
Show member pathways
7.9CTLA4, HLA-C, HLA-DQA1, HLA-DRB1, ITGA4
217.9CTLA4, HLA-C, HLA-DQA1, HLA-DRB1, ITGA4
227.8HLA-C, HLA-DQA1, HLA-DRB1, LTA, TNF
23
Show member pathways
7.8HLA-C, HLA-DQA1, HLA-DRB1, LTA, TNF
24
Show member pathways
7.8HLA-C, HLA-DQA1, HLA-DRB1, LTA, TNF
25
Show member pathways
6.7CTLA4, HLA-C, HLA-DQA1, HLA-DRB1, ITGA4, LTA
26
Show member pathways
6.7CTLA4, HLA-C, HLA-DQA1, HLA-DRB1, ITGA4, LTA

GO Terms for genes affiliated with Sympathetic Ophthalmia

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Cellular components related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:003066910.2HLA-DQA1, HLA-DRB1
2MHC class II protein complexGO:004261310.2HLA-DQA1, HLA-DRB1
3ER to Golgi transport vesicle membraneGO:00125079.8HLA-C, HLA-DQA1, HLA-DRB1
4integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.8HLA-C, HLA-DQA1, HLA-DRB1
5external side of plasma membraneGO:00098979.5CTLA4, HLA-DRB1, TNF
6transport vesicle membraneGO:00306589.4HLA-DQA1, HLA-DRB1
7cell surfaceGO:00099869.1HLA-C, HLA-DRB1, ITGA4, TNF
8plasma membraneGO:00058867.2CTLA4, HLA-C, HLA-DQA1, HLA-DRB1, ITGA4, LTA

Biological processes related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of T cell proliferationGO:004213010.2CTLA4, HLA-DRB1
2antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:000250410.2HLA-DQA1, HLA-DRB1
3humoral immune responseGO:000695910.0LTA, TNF
4negative regulation of growth of symbiont in hostGO:00441309.9LTA, TNF
5positive regulation of chronic inflammatory response to antigenic stimulusGO:00028769.8LTA, TNF
6positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00029259.8LTA, TNF
7leukocyte tethering or rollingGO:00509019.8ITGA4, TNF
8positive regulation of interferon-gamma productionGO:00327299.8LTA, TNF
9antigen processing and presentationGO:00198829.7HLA-C, HLA-DQA1, HLA-DRB1
10interferon-gamma-mediated signaling pathwayGO:00603339.6HLA-C, HLA-DQA1, HLA-DRB1
11positive regulation of apoptotic processGO:00430659.3CTLA4, LTA, TNF
12immune system processGO:00023769.1CTLA4, HLA-C, HLA-DQA1, HLA-DRB1
13T cell costimulationGO:00312958.9CTLA4, HLA-DQA1, HLA-DRB1
14immune responseGO:00069558.0CTLA4, HLA-C, HLA-DQA1, HLA-DRB1, LTA, TNF

Molecular functions related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323959.9HLA-DQA1, HLA-DRB1
2peptide antigen bindingGO:00426059.4HLA-C, HLA-DQA1, HLA-DRB1
3tumor necrosis factor receptor bindingGO:00051649.3LTA, TNF

Sources for Sympathetic Ophthalmia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet