MCID: SYM002
MIFTS: 40

Sympathetic Ophthalmia malady

Categories: Eye diseases, Rare diseases, Immune diseases

Aliases & Classifications for Sympathetic Ophthalmia

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Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 40MESH via Orphanet, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Sympathetic Ophthalmia:

Name: Sympathetic Ophthalmia 11 54 13
Ophthalmia, Sympathetic 39 68
 
Sympathetic Uveitis 11 54

Characteristics:

Orphanet epidemiological data:

54
sympathetic ophthalmia:
Inheritance: Not applicable; Age of onset: All ages

Classifications:

Orphanet: 54 
Rare eye diseases


External Ids:

Disease Ontology11 DOID:12029
ICD1030 H44.13
ICD9CM32 360.11
MeSH39 D009879
SNOMED-CT62 75315001
Orphanet54 ORPHA79098
MESH via Orphanet40 D009879
UMLS via Orphanet69 C0029077
ICD10 via Orphanet31 H44.1

Summaries for Sympathetic Ophthalmia

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Wikipedia:71 Sympathetic ophthalmia (SO) or Sympathetic uveitis is a bilateral diffuse granulomatous uveitis (a kind... more...

MalaCards based summary: Sympathetic Ophthalmia, also known as ophthalmia, sympathetic, is related to conjunctival pigmentation and maligant granulosa cell tumor of ovary, and has symptoms including ciliary hyperaemia An important gene associated with Sympathetic Ophthalmia is CRYAA (Crystallin Alpha A), and among its related pathways are Transcription_NF-kB signaling pathway and Cellular Transformation by HTLV1. Affiliated tissues include eye and retina.

Related Diseases for Sympathetic Ophthalmia

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Diseases related to Sympathetic Ophthalmia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1conjunctival pigmentation29.7HLA-C, HLA-DRB1
2maligant granulosa cell tumor of ovary10.5LTA, TNF
3hemometra10.5LTA, TNF
4streptococcal meningitis10.5LTA, TNF
5neurotic excoriation10.5LTA, TNF
6common variable immunodeficiency10.4HLA-DRB1, TNF
7weber syndrome10.4HLA-DRB1, TNF
8rhizomelic pseudopolyarthritis10.4HLA-DRB1, TNF
9spondylohypoplasia, arthrogryposis and popliteal pterygium10.4LTA, TNF
10epstein-barr virus hepatitis10.4HLA-DRB1, TNF
11epididymis adenomatoid tumor10.4LTA, TNF
12primary biliary cirrhosis10.4LTA, TNF
13lymphocytic colitis10.4HLA-DRB1, TNF
14peripheral t-cell lymphoma10.4HLA-DRB1, TNF
15hernia of ovary and fallopian tube10.4HLA-DRB1, TNF
16potato nose10.4HLA-DRB1, TNF
17sensorineural hearing loss10.4HLA-DRB1, TNF
18mastocytosis cutaneous with short stature conductive hearing loss and microtia10.4HLA-DRB1, TNF
19fibrous histiocytoma10.4HLA-DRB1, TNF
20allergic hypersensitivity disease10.4HLA-DRB1, TNF
21nephrosclerosis10.3HLA-DRB1, TNF
22keratomalacia10.3HLA-C, TNF
23chronic apical periodontitis10.3HLA-DRB1, TNF
24common cold10.3LTA, TNF
25ovarian endometrioid malignant adenofibroma10.3ITGA4, TNF
26cutaneous porphyria10.3LTA, TNF
27retroperitoneal fibrosis10.3HLA-DRB1, TNF
28reproductive system disease10.3HLA-DRB1, TNF
29bacteriuria10.3LTA, TNF
30hepatic coma10.3HLA-DRB1, TNF
31choroiditis10.3
32retinitis10.3
33antigen-peptide-transporter 2 deficiency10.3CTLA4, TNF
34mitochondrial encephalomyopathy10.3HLA-C, HLA-DRB1
35orbital periostitis10.3HLA-C, TNF
36multifocal choroiditis10.3HLA-DRB1, ITGA4
37foster-kennedy syndrome10.2HLA-C, HLA-DRB1
38endophthalmitis10.2
39binocular vision disease10.2CTLA4, TNF
40isolated congenital auditory ossicle malformation10.2CTLA4, TNF
41autosomal recessive congenital methemoglobinemia10.2CTLA4, HLA-DRB1
42cataract10.2
43retinal detachment10.2
44cirrhotic cardiomyopathy10.2HLA-C, HLA-DRB1
45peri-anal fistula10.2CTLA4, HLA-DRB1
46dentinogenesis imperfecta10.2HLA-DRB1, TNF
47congenital syphilis10.2HLA-C, HLA-DRB1
48breast carcinoma in situ10.1HLA-DRB1, TNF
49vogt-koyanagi-harada disease10.1
50bullous retinoschisis10.1HLA-DRB1, LTA, TNF

Graphical network of the top 20 diseases related to Sympathetic Ophthalmia:



Diseases related to sympathetic ophthalmia

Symptoms & Phenotypes for Sympathetic Ophthalmia

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UMLS symptoms related to Sympathetic Ophthalmia:


ciliary hyperaemia

Drugs & Therapeutics for Sympathetic Ophthalmia

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Drugs for Sympathetic Ophthalmia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Triamcinoloneapproved, vet_approvedPhase 1, Phase 2482124-94-731307
Synonyms:
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione
11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione
124-94-7
4-08-00-03629 (Beilstein Handbook Reference)
83474-03-7
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-16-alpha-hydroxyprednisolone
9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy
9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-hydroxyprednisolone
9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-16α-hydroxyprednisolone
AC-2072
AC1L1LDH
AC1Q5HJC
Adcortyl
Aristocort
Aristocort A
Aristocort Tablets
Aristogel
Aristospan
Azmacort
BPBio1_000154
BRD-K77554836-001-03-3
BRN 2341955
BSPBio_000140
Bio-0662
C21H27FO6
CHEMBL1451
CID31307
CL 19823
Celeste
Cinolone
Cinolone-T
D00385
D014221
DB00620
Delphicort
EINECS 204-718-7
EU-0101179
Fluoxiprednisolone
Fluoxyprednisolone
Flutex
Fougera
HMS1568G22
HMS2090D12
HSDB 3194
Kenacort
Kenacort (TN)
Kenacort-A
Kenacort-AG
Kenacort-Ag
Kenalog
Kenalog in Orabase
Kenalog-10
Kenalog-40
Kenalog-H
LS-698
Ledercort
Lopac0_001179
 
MLS000028542
MLS001066543
MLS002695935
MolPort-002-528-981
Mycolog
NCGC00021580-03
NCGC00021580-04
NCGC00021580-05
NCGC00021580-06
NCGC00021580-07
NCI60_000750
NSC 13397
NSC13397
Nasacort
Nasacort Aq
Nasacort Hfa
Omcilon
Omicilon
Oracort
Oralone
Orion
Polcortolon
Pregna-1,4-diene-3,20-dio
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)
Prestwick0_000120
Prestwick1_000120
Prestwick2_000120
Prestwick3_000120
Prestwick_438
Rodinolone
S1933_Selleck
SK-Triamcinolone
SMP1_000300
SMR000058333
SPBio_002079
Sk-Triamcinolone
T6376_SIGMA
TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))
Tiamcinolonum
Tiamcinolonum [INN-Latin]
Tri-Nasal
Triacet
Triacort
Triam-Tablinen
Triamcet
Triamcinalone
Triamcinlon
Triamcinolon
Triamcinolona
Triamcinolona [INN-Spanish]
Triamcinolone (JP15/USP/INN)
Triamcinolone [USAN:INN:BAN:JAN]
Triamcinolone acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Triamcinolonum
Triamcinolonum [INN]
Triatex
Tricortale
Triderm
Trilone
Tristoject
Trymex
UNII-1ZK20VI6TY
Vetalog
Volon
Volon A
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ
ZINC03882036
droxypregna-1,4-diene-3,20-dione
ione
nchembio.2007.53-comp7
triamcinolone
2triamcinolone acetonidePhase 1, Phase 2482
3Triamcinolone diacetatePhase 1, Phase 2482
4Triamcinolone hexacetonidePhase 1, Phase 2482
5Immunosuppressive AgentsPhase 1, Phase 212770
6Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 1, Phase 212767
7glucocorticoidsPhase 1, Phase 24920
8Hormone AntagonistsPhase 1, Phase 212778
9HormonesPhase 1, Phase 213979
10Anti-Inflammatory AgentsPhase 1, Phase 210355

Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety Study of Conventional Versus Micropulse Transscleral Cyclophotocoagulation in Treating End-Stage GlaucomaUnknown statusNCT00349414Phase 1, Phase 2
2Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat UveitisCompletedNCT01789320Phase 1, Phase 2
3Safety and Efficacy of AIN457 in Noninfectious UveitisCompletedNCT00685399Phase 2
4Adjunctive Photodynamic Therapy + Aflibercept vs. Afilbercept Alone for PDA in NV AMDWithdrawnNCT02457026

Search NIH Clinical Center for Sympathetic Ophthalmia


Cochrane evidence based reviews: ophthalmia, sympathetic

Genetic Tests for Sympathetic Ophthalmia

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Anatomical Context for Sympathetic Ophthalmia

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MalaCards organs/tissues related to Sympathetic Ophthalmia:

36
Eye, Retina

Publications for Sympathetic Ophthalmia

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Articles related to Sympathetic Ophthalmia:

(show top 50)    (show all 320)
idTitleAuthorsYear
1
Multimodal Imaging in Sympathetic Ophthalmia. (27960610)
2016
2
AN ATYPICAL CASE OF SYMPATHETIC OPHTHALMIA AFTER LIMBAL CORNEAL LACERATION. (27124790)
2016
3
A rare case of atypical sympathetic ophthalmia post therapeutic keratoplasty. (27638462)
2016
4
Sympathetic ophthalmia following a conjunctival flap procedure for corneal perforation. (26976837)
2016
5
Long-Term Drug-Free Remission and Visual Outcomes in Sympathetic Ophthalmia. (26808121)
2016
6
Characteristics of Sympathetic Ophthalmia in a Single International Center. (27651849)
2016
7
Bilateral hearing impairment as the initial symptom of sympathetic ophthalmia. (25720920)
2015
8
SYMPATHETIC OPHTHALMIA: Clinicopathologic Correlation in a Consecutive Case Series. (25719985)
2015
9
A case of sympathetic ophthalmia after 23-gauge transconjunctival sutureless vitrectomy. (26028951)
2015
10
Sympathetic Ophthalmia after Ocular Wasp Sting. (26635462)
2015
11
Enhanced depth imaging OCT (EDI-OCT) findings in acute phase of sympathetic ophthalmia. (25772275)
2015
12
Sympathetic ophthalmia caused by a severe ocular chemical burn: a case report and literature review. (25932266)
2015
13
Spontaneous dislocation of a fluocinolone acetonide implant (retisert) into the anterior chamber and its successful extraction in sympathetic ophthalmia. (25411930)
2015
14
Classical pathology of sympathetic ophthalmia presented in a unique case. (25067979)
2014
15
Gender differences in vogt-koyanagi-harada disease and sympathetic ophthalmia. (24734166)
2014
16
Sympathetic ophthalmia following diode laser cyclophotocoagulation. (24711656)
2014
17
Sympathetic ophthalmia after diode laser cyclophotocoagulation: now an issue in informed consent. (25103662)
2014
18
Long-term, drug-free remission of sympathetic ophthalmia with high-dose, short-term chlorambucil therapy. (24572676)
2014
19
Adalimumab for pediatric sympathetic ophthalmia. (25010359)
2014
20
Multiple serous retinal detachments seen on wide-field imaging in a patient with sympathetic ophthalmia. (25171189)
2014
21
Spectral-Domain Optical Coherence Tomography of Sympathetic Ophthalmia With Dalen-Fuchs Nodules. (25347826)
2014
22
Presumed sympathetic ophthalmia after scleral buckling surgery. (25383825)
2013
23
Sympathetic Ophthalmia in Pediatric Age Group: Clinical Features and Challenges in Management in a Tertiary Center in Southern India. (24131076)
2013
24
High definition spectral domain optical coherence tomography of retinal pigment epithelial rip in a case of sympathetic ophthalmia. (23514588)
2013
25
Reversible alopecia in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia. (23514340)
2013
26
Incidence of hypotony and sympathetic ophthalmia following trans-scleral cyclophotocoagulation for glaucoma and a report of risk factors. (23433313)
2013
27
Sympathetic ophthalmia: to the twenty-first century and beyond. (23724856)
2013
28
Sympathetic ophthalmia with sensorineural deafness - report of a case. (24225003)
2013
29
Sympathetic ophthalmia following enucleation. (22124788)
2013
30
Continued vision loss from progressive expansion of inactive chorioretinal scars in a myopic patient with well-controlled sympathetic ophthalmia. (25389936)
2012
31
Update on sympathetic ophthalmia. (22346110)
2012
32
Multimodality diagnostic imaging in a case of sympathetic ophthalmia. (22594960)
2012
33
Imaging for sympathetic ophthalmia: impact on the diagnosis and management. (22954939)
2012
34
Mitochondrial oxidative stress initiates visual loss in sympathetic ophthalmia. (22476625)
2012
35
Immunopathologic processes in sympathetic ophthalmia as signified by microRNA profiling. (22589448)
2012
36
Sympathetic ophthalmia in HIV infection. A clinicopathological case report. (22411458)
2012
37
Sympathetic ophthalmia after proton beam irradiation for choroA^dal melanoma. (22646709)
2012
38
Sympathetic ophthalmia: a review of literature. (22677732)
2012
39
Missed perforation presenting as sympathetic ophthalmia in an adolescent Malay girl. (22914237)
2012
40
Presumed occult globe rupture resulting in sympathetic ophthalmia. (22200914)
2012
41
Expression of I+-crystallin in the retina of human sympathetic ophthalmia. (22052021)
2012
42
Sympathetic ophthalmia: enucleation or evisceration? (21876595)
2011
43
A case of sympathetic ophthalmia after a severe acanthamoeba keratitis. (21471815)
2011
44
The role of perivascular melanophage infiltrates in the conjunctiva in sympathetic ophthalmia. (21595534)
2011
45
Management and clinical outcome of penetrating keratoplasty for long-term corneal changes in sympathetic ophthalmia. (21772984)
2011
46
Challenges of managing sympathetic ophthalmia in a young child and the role of infliximab. (21732578)
2011
47
Sympathetic ophthalmia. (21958181)
2011
48
Inflammatory cytokine and chemokine expression in sympathetic ophthalmia: a pilot study. (21751146)
2011
49
Sympathetic ophthalmia in an infected post-scleral buckling eye. (21603735)
2011
50
The association of systemic disorders with Vogt-Koyanagi-Harada and sympathetic ophthalmia. (21717180)
2011

Variations for Sympathetic Ophthalmia

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Expression for genes affiliated with Sympathetic Ophthalmia

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Search GEO for disease gene expression data for Sympathetic Ophthalmia.

Pathways for genes affiliated with Sympathetic Ophthalmia

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Pathways related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathwaysScoreTop Affiliating Genes
19.5LTA, TNF
2
Show member pathways
9.5LTA, TNF
39.4HLA-DRB1, TNF
49.2HLA-DQA1, HLA-DRB1
5
Show member pathways
9.0HLA-C, LTA, TNF
69.0ITGA4, LTA, TNF
78.9HLA-DRB1, ITGA4, TNF
8
Show member pathways
8.8HLA-C, HLA-DQA1, HLA-DRB1
98.8HLA-C, HLA-DQA1, HLA-DRB1
108.8HLA-C, HLA-DQA1, HLA-DRB1
11
Show member pathways
8.7CTLA4, HLA-DQA1, HLA-DRB1
128.7CTLA4, HLA-DQA1, HLA-DRB1
13
Show member pathways
8.7CTLA4, HLA-DQA1, HLA-DRB1
148.6HLA-DQA1, HLA-DRB1, TNF
158.4CTLA4, ITGA4, LTA, TNF
16
Show member pathways
8.3HLA-C, HLA-DQA1, HLA-DRB1, ITGA4
17
Show member pathways
8.2HLA-C, HLA-DQA1, LTA, TNF
188.1CTLA4, HLA-DQA1, HLA-DRB1, TNF
19
Show member pathways
8.1HLA-DQA1, HLA-DRB1, ITGA4, TNF
20
Show member pathways
7.8HLA-C, HLA-DQA1, HLA-DRB1, LTA, TNF
217.8HLA-C, HLA-DQA1, HLA-DRB1, LTA, TNF
227.7CTLA4, HLA-C, HLA-DQA1, HLA-DRB1, ITGA4
23
Show member pathways
6.7CTLA4, HLA-C, HLA-DQA1, HLA-DRB1, ITGA4, LTA
24
Show member pathways
6.7CTLA4, HLA-C, HLA-DQA1, HLA-DRB1, ITGA4, LTA

GO Terms for genes affiliated with Sympathetic Ophthalmia

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Cellular components related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:003066910.0HLA-DQA1, HLA-DRB1
2MHC class II protein complexGO:004261310.0HLA-DQA1, HLA-DRB1
3ER to Golgi transport vesicle membraneGO:00125079.6HLA-C, HLA-DQA1, HLA-DRB1
4integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.6HLA-C, HLA-DQA1, HLA-DRB1
5cell surfaceGO:00099869.3HLA-C, HLA-DRB1, ITGA4, TNF
6transport vesicle membraneGO:00306589.2HLA-DQA1, HLA-DRB1
7plasma membraneGO:00058867.2CTLA4, HLA-C, HLA-DQA1, HLA-DRB1, ITGA4, LTA

Biological processes related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1humoral immune responseGO:000695910.1LTA, TNF
2negative regulation of growth of symbiont in hostGO:004413010.1LTA, TNF
3positive regulation of chronic inflammatory response to antigenic stimulusGO:000287610.0LTA, TNF
4positive regulation of humoral immune response mediated by circulating immunoglobulinGO:000292510.0LTA, TNF
5leukocyte tethering or rollingGO:005090110.0ITGA4, TNF
6positive regulation of interferon-gamma productionGO:003272910.0LTA, TNF
7positive regulation of apoptotic processGO:00430659.5CTLA4, LTA, TNF
8interferon-gamma-mediated signaling pathwayGO:00603339.4HLA-C, HLA-DQA1, HLA-DRB1
9T cell costimulationGO:00312958.7CTLA4, HLA-DQA1, HLA-DRB1

Molecular functions related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00051649.5LTA, TNF
2peptide antigen bindingGO:00426059.2HLA-C, HLA-DQA1, HLA-DRB1

Sources for Sympathetic Ophthalmia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet