MCID: SYM002
MIFTS: 40

Sympathetic Ophthalmia

Categories: Eye diseases, Rare diseases, Immune diseases

Aliases & Classifications for Sympathetic Ophthalmia

MalaCards integrated aliases for Sympathetic Ophthalmia:

Name: Sympathetic Ophthalmia 12 56 14
Ophthalmia, Sympathetic 42 69
Sympathetic Uveitis 12 56

Characteristics:

Orphanet epidemiological data:

56
sympathetic ophthalmia
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:12029
ICD10 33 H44.13
ICD9CM 35 360.11
MeSH 42 D009879
SNOMED-CT 64 75315001
Orphanet 56 ORPHA79098
MESH via Orphanet 43 D009879
UMLS via Orphanet 70 C0029077
ICD10 via Orphanet 34 H44.1
UMLS 69 C0029077

Summaries for Sympathetic Ophthalmia

MalaCards based summary : Sympathetic Ophthalmia, also known as ophthalmia, sympathetic, is related to spondylocostal dysostosis 4 and type 1 papillary adenoma of the kidney. An important gene associated with Sympathetic Ophthalmia is CRYAA (Crystallin Alpha A), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Triamcinolone and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include eye and retina.

Wikipedia : 72 Sympathetic ophthalmia (SO) or Sympathetic uveitis is a bilateral diffuse granulomatous uveitis (a kind... more...

Related Diseases for Sympathetic Ophthalmia

Diseases related to Sympathetic Ophthalmia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
id Related Disease Score Top Affiliating Genes
1 spondylocostal dysostosis 4 10.6 LTA TNF
2 type 1 papillary adenoma of the kidney 10.6 LTA TNF
3 spirillary rat-bite fever 10.6 LTA TNF
4 toxoplasmosis 10.6 LTA TNF
5 idiopathic dilatation of the pulmonary artery 10.5 LTA TNF
6 liver leiomyoma 10.5 LTA TNF
7 migraine with brainstem aura 10.5 HLA-DRB1 TNF
8 cauda equina syndrome 10.5 LTA TNF
9 mosaic trisomy 1 10.5 HLA-DRB1 TNF
10 epstein-barr virus hepatitis 10.5 HLA-DRB1 TNF
11 hypogonadotropism 10.5 LTA TNF
12 limb-body wall complex 10.5 HLA-DRB1 TNF
13 primary biliary cirrhosis 10.5 LTA TNF
14 moved to 244450 10.5 HLA-DRB1 TNF
15 not otherwise specified 3-mga-uria type 10.5 HLA-DRB1 TNF
16 riboflavin transporter deficiency 10.5 HLA-DRB1 TNF
17 lymphocytic colitis 10.5 HLA-DRB1 TNF
18 central nervous system leiomyosarcoma 10.5 HLA-DRB1 TNF
19 aseptic meningitis 10.5 HLA-DRB1 TNF
20 hepadnavirus infection 10.4 HLA-DRB1 TNF
21 cryptococcosis 10.4 HLA-DRB1 TNF
22 chronic apical periodontitis 10.4 HLA-C TNF
23 patau syndrome 10.4 HLA-DRB1 TNF
24 endogenous depression 10.4 HLA-DRB1 TNF
25 disease of mental health 10.4 HLA-DRB1 TNF
26 antigen-peptide-transporter 2 deficiency 10.3 CTLA4 TNF
27 progressive myoclonus epilepsy 10.3 HLA-C HLA-DRB1
28 rift valley fever 10.3 LTA TNF
29 extrahepatic bile duct adenocarcinoma 10.3 HLA-DRB1 TNF
30 adenocarcinoid tumor 10.3 LTA TNF
31 c1 inhibitor deficiency 10.3 ITGB3 TNF
32 iida kannari syndrome 10.3 HLA-DRB1 TNF
33 orbital osteomyelitis 10.3 HLA-C TNF
34 choroiditis 10.3
35 retinitis 10.3
36 psychologic dyspareunia 10.3 CTLA4 TNF
37 clopidogrel resistance 10.3 CTLA4 HLA-DRB1
38 blood group incompatibility 10.2 HLA-C HLA-DRB1
39 celiac disease 3 10.2 CTLA4 HLA-DRB1
40 dentinogenesis imperfecta 10.2 HLA-DRB1 TNF
41 legionellosis 10.2 LTA TNF
42 left bundle branch hemiblock 10.2 HLA-DRB1 TNF
43 endophthalmitis 10.2
44 cataract 10.2
45 retinal detachment 10.2
46 classic hairy cell leukemia 10.2 HLA-C HLA-DRB1
47 abnormal retinal correspondence 10.2 CTLA4 TNF
48 pulmonary hemosiderosis 10.1 HLA-DRB1 LTA TNF
49 inflammatory bowel disease 3 10.1 HLA-DRB1 LTA TNF
50 aspartylglucosaminuria 10.1 HLA-DRB1 LTA TNF

Graphical network of the top 20 diseases related to Sympathetic Ophthalmia:



Diseases related to Sympathetic Ophthalmia

Symptoms & Phenotypes for Sympathetic Ophthalmia

Drugs & Therapeutics for Sympathetic Ophthalmia

Drugs for Sympathetic Ophthalmia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 1, Phase 2 124-94-7 31307
2
Benzocaine Approved Phase 2 1994-09-7, 94-09-7 2337
3 tannic acid Approved, Nutraceutical Phase 2
4 Anti-Inflammatory Agents Phase 1, Phase 2
5 glucocorticoids Phase 1, Phase 2
6 Hormone Antagonists Phase 1, Phase 2
7 Hormones Phase 1, Phase 2
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
9 Immunosuppressive Agents Phase 1, Phase 2
10 triamcinolone acetonide Phase 1, Phase 2
11 Triamcinolone diacetate Phase 1, Phase 2
12 Triamcinolone hexacetonide Phase 1, Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Safety Study of Conventional Versus Micropulse Transscleral Cyclophotocoagulation in Treating End-Stage Glaucoma Unknown status NCT00349414 Phase 1, Phase 2
2 Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis Completed NCT01789320 Phase 1, Phase 2 triamcinolone acetonide (Triesence®)
3 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
4 Adjunctive Photodynamic Therapy + Aflibercept vs. Afilbercept Alone for PDA in NV AMD Withdrawn NCT02457026 Aflibercept;Triamcinolone Acetonide;Verteporfin

Search NIH Clinical Center for Sympathetic Ophthalmia

Cochrane evidence based reviews: ophthalmia, sympathetic

Genetic Tests for Sympathetic Ophthalmia

Anatomical Context for Sympathetic Ophthalmia

MalaCards organs/tissues related to Sympathetic Ophthalmia:

39
Eye, Retina

Publications for Sympathetic Ophthalmia

Articles related to Sympathetic Ophthalmia:

(show top 50) (show all 326)
id Title Authors Year
1
Association of a PDCD1 Polymorphism With Sympathetic Ophthalmia in Han Chinese. ( 28846771 )
2017
2
Cyclophotocoagulation-induced sympathetic ophthalmia in a Coats' disease patient supported by histopathology and immunohistochemistry. ( 28820164 )
2017
3
Lymphocytic Meningitis in Patients with Sympathetic Ophthalmia. ( 28281853 )
2017
4
Sympathetic ophthalmia related to conjunctival invasive squamous-cell carcinoma. ( 28820163 )
2017
5
Sympathetic Ophthalmia. ( 28414613 )
2017
6
Sympathetic Ophthalmia Following Accidental Burn with Hot Water Involving the Other Eye. ( 28910553 )
2017
7
Characteristics of Sympathetic Ophthalmia in a Single International Center. ( 27651849 )
2016
8
A rare case of atypical sympathetic ophthalmia post therapeutic keratoplasty. ( 27638462 )
2016
9
Multimodal Imaging in Sympathetic Ophthalmia. ( 27960610 )
2016
10
Long-Term Drug-Free Remission and Visual Outcomes in Sympathetic Ophthalmia. ( 26808121 )
2016
11
Sympathetic ophthalmia following a conjunctival flap procedure for corneal perforation. ( 26976837 )
2016
12
AN ATYPICAL CASE OF SYMPATHETIC OPHTHALMIA AFTER LIMBAL CORNEAL LACERATION. ( 27124790 )
2016
13
A case of sympathetic ophthalmia after 23-gauge transconjunctival sutureless vitrectomy. ( 26028951 )
2015
14
Sympathetic Ophthalmia after Ocular Wasp Sting. ( 26635462 )
2015
15
Enhanced depth imaging OCT (EDI-OCT) findings in acute phase of sympathetic ophthalmia. ( 25772275 )
2015
16
SYMPATHETIC OPHTHALMIA: Clinicopathologic Correlation in a Consecutive Case Series. ( 25719985 )
2015
17
Bilateral hearing impairment as the initial symptom of sympathetic ophthalmia. ( 25720920 )
2015
18
Sympathetic ophthalmia caused by a severe ocular chemical burn: a case report and literature review. ( 25932266 )
2015
19
Spontaneous dislocation of a fluocinolone acetonide implant (retisert) into the anterior chamber and its successful extraction in sympathetic ophthalmia. ( 25411930 )
2015
20
Long-term, drug-free remission of sympathetic ophthalmia with high-dose, short-term chlorambucil therapy. ( 24572676 )
2014
21
Multiple serous retinal detachments seen on wide-field imaging in a patient with sympathetic ophthalmia. ( 25171189 )
2014
22
Sympathetic ophthalmia following diode laser cyclophotocoagulation. ( 24711656 )
2014
23
Gender differences in vogt-koyanagi-harada disease and sympathetic ophthalmia. ( 24734166 )
2014
24
Classical pathology of sympathetic ophthalmia presented in a unique case. ( 25067979 )
2014
25
Adalimumab for pediatric sympathetic ophthalmia. ( 25010359 )
2014
26
Spectral-Domain Optical Coherence Tomography of Sympathetic Ophthalmia With Dalen-Fuchs Nodules. ( 25347826 )
2014
27
Sympathetic ophthalmia after diode laser cyclophotocoagulation: now an issue in informed consent. ( 25103662 )
2014
28
Sympathetic ophthalmia following enucleation. ( 22124788 )
2013
29
High definition spectral domain optical coherence tomography of retinal pigment epithelial rip in a case of sympathetic ophthalmia. ( 23514588 )
2013
30
Sympathetic ophthalmia with sensorineural deafness - report of a case. ( 24225003 )
2013
31
Reversible alopecia in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia. ( 23514340 )
2013
32
Presumed sympathetic ophthalmia after scleral buckling surgery. ( 25383825 )
2013
33
Sympathetic Ophthalmia in Pediatric Age Group: Clinical Features and Challenges in Management in a Tertiary Center in Southern India. ( 24131076 )
2013
34
Sympathetic ophthalmia: to the twenty-first century and beyond. ( 23724856 )
2013
35
Incidence of hypotony and sympathetic ophthalmia following trans-scleral cyclophotocoagulation for glaucoma and a report of risk factors. ( 23433313 )
2013
36
Update on sympathetic ophthalmia. ( 22346110 )
2012
37
Sympathetic ophthalmia in HIV infection. A clinicopathological case report. ( 22411458 )
2012
38
Missed perforation presenting as sympathetic ophthalmia in an adolescent Malay girl. ( 22914237 )
2012
39
Sympathetic ophthalmia after proton beam irradiation for choroA^dal melanoma. ( 22646709 )
2012
40
Multimodality diagnostic imaging in a case of sympathetic ophthalmia. ( 22594960 )
2012
41
Sympathetic ophthalmia: a review of literature. ( 22677732 )
2012
42
Continued vision loss from progressive expansion of inactive chorioretinal scars in a myopic patient with well-controlled sympathetic ophthalmia. ( 25389936 )
2012
43
Imaging for sympathetic ophthalmia: impact on the diagnosis and management. ( 22954939 )
2012
44
Presumed occult globe rupture resulting in sympathetic ophthalmia. ( 22200914 )
2012
45
Expression of I+-crystallin in the retina of human sympathetic ophthalmia. ( 22052021 )
2012
46
Immunopathologic processes in sympathetic ophthalmia as signified by microRNA profiling. ( 22589448 )
2012
47
Mitochondrial oxidative stress initiates visual loss in sympathetic ophthalmia. ( 22476625 )
2012
48
The role of perivascular melanophage infiltrates in the conjunctiva in sympathetic ophthalmia. ( 21595534 )
2011
49
The association of systemic disorders with Vogt-Koyanagi-Harada and sympathetic ophthalmia. ( 21717180 )
2011
50
Sympathetic ophthalmia: enucleation or evisceration? ( 21876595 )
2011

Variations for Sympathetic Ophthalmia

Expression for Sympathetic Ophthalmia

Search GEO for disease gene expression data for Sympathetic Ophthalmia.

Pathways for Sympathetic Ophthalmia

Pathways related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 26)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 ITGB3 LTA
2
Show member pathways
13.02 HLA-C HLA-DQA1 HLA-DRB1 ITGB3 LTA TNF
3
Show member pathways
12.71 HLA-C HLA-DQA1 HLA-DRB1 ITGB3
4
Show member pathways
12.49 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF
5
Show member pathways
12.34 HLA-DQA1 HLA-DRB1 TNF
6
Show member pathways
12.27 HLA-C HLA-DQA1 HLA-DRB1
7
Show member pathways
12.14 CTLA4 HLA-DQA1 HLA-DRB1
8 12.04 HLA-C HLA-DQA1 HLA-DRB1
9
Show member pathways
12 HLA-DQA1 HLA-DRB1 TNF
10 11.95 HLA-DQA1 HLA-DRB1 TNF
11
Show member pathways
11.92 CTLA4 HLA-DQA1 HLA-DRB1
12
Show member pathways
11.88 HLA-C LTA TNF
13 11.85 HLA-C HLA-DQA1 HLA-DRB1 ITGB3
14
Show member pathways
11.84 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF
15 11.78 CTLA4 HLA-C HLA-DQA1 HLA-DRB1
16 11.76 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF
17
Show member pathways
11.55 HLA-DQA1 HLA-DRB1
18 11.54 HLA-DQA1 HLA-DRB1 ITGB3 TNF
19 11.5 CTLA4 HLA-DQA1 HLA-DRB1
20 11.48 CTLA4 LTA TNF
21 11.41 CTLA4 HLA-DQA1 HLA-DRB1 TNF
22 11.37 HLA-DQA1 HLA-DRB1
23 11.35 LTA TNF
24
Show member pathways
11.31 LTA TNF
25
Show member pathways
11.23 ITGB3 TNF
26 11.04 HLA-DRB1 TNF

GO Terms for Sympathetic Ophthalmia

Cellular components related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.95 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 ITGB3 LTA
2 cell surface GO:0009986 9.56 HLA-C HLA-DRB1 ITGB3 TNF
3 external side of plasma membrane GO:0009897 9.5 CTLA4 HLA-DRB1 TNF
4 transport vesicle membrane GO:0030658 9.43 HLA-DQA1 HLA-DRB1
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.37 HLA-DQA1 HLA-DRB1
6 MHC class II protein complex GO:0042613 9.16 HLA-DQA1 HLA-DRB1
7 ER to Golgi transport vesicle membrane GO:0012507 9.13 HLA-C HLA-DQA1 HLA-DRB1
8 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.8 HLA-C HLA-DQA1 HLA-DRB1

Biological processes related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.76 CTLA4 HLA-C HLA-DQA1 HLA-DRB1
2 T cell costimulation GO:0031295 9.54 CTLA4 HLA-DQA1 HLA-DRB1
3 humoral immune response GO:0006959 9.52 LTA TNF
4 positive regulation of interferon-gamma production GO:0032729 9.51 LTA TNF
5 interferon-gamma-mediated signaling pathway GO:0060333 9.5 HLA-C HLA-DQA1 HLA-DRB1
6 negative regulation of T cell proliferation GO:0042130 9.49 CTLA4 HLA-DRB1
7 negative regulation of growth of symbiont in host GO:0044130 9.48 LTA TNF
8 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.43 HLA-DQA1 HLA-DRB1
9 negative regulation of lipid storage GO:0010888 9.4 ITGB3 TNF
10 antigen processing and presentation GO:0019882 9.33 HLA-C HLA-DQA1 HLA-DRB1
11 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.26 LTA TNF
12 immune response GO:0006955 9.1 CTLA4 HLA-C HLA-DQA1 HLA-DRB1 LTA TNF
13 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 8.96 LTA TNF

Molecular functions related to Sympathetic Ophthalmia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 9.16 LTA TNF
2 MHC class II receptor activity GO:0032395 8.96 HLA-DQA1 HLA-DRB1
3 peptide antigen binding GO:0042605 8.8 HLA-C HLA-DQA1 HLA-DRB1

Sources for Sympathetic Ophthalmia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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