Aliases & Classifications for Syncope

Aliases & Descriptions for Syncope:

Name: Syncope 51 29 3 3

Summaries for Syncope

NINDS : 51 Syncope is a medical term used to describe a temporary loss of consciousness due to the sudden decline of blood flow to the brain. Syncope is commonly called fainting or “passing out.” If an individual is about to faint, he or she will feel dizzy, lightheaded, or nauseous and their field of vision may “white out” or “black out.”  The skin may be cold and clammy.  The person drops to the floor as he or she loses consciousness.  After fainting, an individual may be unconscious for a minute or two, but will revive and slowly return to normal.  Syncope can occur in otherwise healthy people and affects all age groups, but occurs more often in the elderly. 

MalaCards based summary : Syncope is related to sick sinus syndrome 1 and short qt syndrome 2. An important gene associated with Syncope is SLC6A2 (Solute Carrier Family 6 Member 2), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and fMLP Pathway. The drugs Amiodarone and Ranolazine have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and brain.

Wikipedia : 71 Syncope may refer to one of the... more...

Related Diseases for Syncope

Diseases related to Syncope via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 298)
id Related Disease Score Top Affiliating Genes
1 sick sinus syndrome 1 31.1 KCNH2 KCNQ1 SCN5A
2 short qt syndrome 2 30.9 KCNH2 KCNQ1 SCN5A
3 atrial fibrillation, familial, 10 30.6 KCNH2 KCNQ1 SCN5A
4 atrial fibrillation, familial, 3 29.5 CALM1 CALM2 CALM3 KCNH2 KCNJ2 KCNQ1
5 third-degree atrioventricular block 29.4 KCNH2 KCNQ1 SCN5A
6 subclavian steal syndrome 29.1 CALM1 CALM2 CALM3
7 syncope, familial vasovagal 12.1
8 ventricular extrasystoles with syncope, perodactyly, and robin sequence 11.8
9 ventricular extrasystoles with syncopal episodes - perodactyly - robin sequence 11.8
10 catecholaminergic polymorphic ventricular tachycardia 11.5
11 ventricular tachycardia, catecholaminergic polymorphic, 1 11.5
12 ventricular tachycardia, catecholaminergic polymorphic, 2 11.4
13 ventricular tachycardia, catecholaminergic polymorphic, 4 11.4
14 jervell and lange-nielsen syndrome 11.4
15 fainting 11.3
16 orthostatic intolerance 10.9
17 brugada syndrome 10.9
18 wolff-parkinson-white syndrome 10.9
19 postural hypotension 10.9
20 long qt syndrome 9 10.7
21 long qt syndrome 2 10.7
22 long qt syndrome 13 10.7
23 sinoatrial node dysfunction and deafness 10.7
24 long qt syndrome-3 10.7
25 heart block, progressive, type ia 10.7
26 progressive familial heart block, type ii 10.7
27 sick sinus syndrome 3 10.7
28 long qt syndrome 1 10.7
29 long qt syndrome 12 10.7
30 dementia, lewy body 10.7
31 cardiac arrhythmia, ankyrin-b-related 10.7
32 long qt syndrome 6 10.7
33 long qt syndrome 5 10.7
34 long qt syndrome-10 10.7
35 andersen syndrome 10.7
36 long qt syndrome-11 10.7
37 cardiomyopathy, hypertrophic, 25 10.5
38 familial atrial fibrillation 10.5
39 chronic thromboembolic pulmonary hypertension 10.5
40 pure autonomic failure 10.5
41 hyperinsulinemic hypoglycemia, familial, 7 10.5
42 cardiomyopathy, hypertrophic, 13 10.5
43 short qt syndrome 1 10.5
44 atrial fibrillation, familial, 7 10.5
45 short qt syndrome 3 10.5
46 autosomal recessive limb-girdle muscular dystrophy type 2x 10.5
47 atrial fibrillation, familial, 12 10.5
48 atrial fibrillation, familial, 9 10.5
49 progressive familial heart block 10.5
50 atrial fibrillation, familial, 11 10.5

Graphical network of the top 20 diseases related to Syncope:



Diseases related to Syncope

Symptoms & Phenotypes for Syncope

Drugs & Therapeutics for Syncope

Drugs for Syncope (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 235)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amiodarone Approved, Investigational Phase 4,Phase 3 1951-25-3 2157
2
Ranolazine Approved, Investigational Phase 4,Phase 2 142387-99-3, 95635-55-5 56959
3
Testosterone Approved, Investigational Phase 4 58-22-0 6013
4
Losartan Approved Phase 4 114798-26-4 3961
5
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3 58-93-5 3639
6
Amlodipine Approved Phase 4 88150-42-9 2162
7
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
8
Propranolol Approved, Investigational Phase 4,Phase 2 525-66-6 4946
9
Midodrine Approved Phase 4 133163-28-7, 42794-76-3 4195
10
Fludrocortisone Approved Phase 4 127-31-1 31378
11
Treprostinil Approved, Investigational Phase 4 81846-19-7 54786 6918140
12
Epoprostenol Approved Phase 4 61849-14-7, 35121-78-9 5280427 5282411
13
Methyltestosterone Approved Phase 4 58-18-4 6010
14
Donepezil Approved Phase 4 120014-06-4 3152
15 Sodium Channel Blockers Phase 4,Phase 3,Phase 2
16 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
17 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3
18 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3
19 Cytochrome P-450 CYP2D6 Inhibitors Phase 4,Phase 3
20 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3
21 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
22 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2
23 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
24 Vasodilator Agents Phase 4,Phase 3,Phase 2
25 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2
26 Potassium Channel Blockers Phase 4,Phase 3
27 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2
28
Angiotensin II Phase 4,Phase 3 68521-88-0, 11128-99-7 65143 172198
29 Tezosentan Phase 4
30 Testosterone undecanoate Phase 4
31 calcium channel blockers Phase 4
32 diuretics Phase 4,Phase 3,Phase 1,Phase 2
33 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
34 Natriuretic Agents Phase 4,Phase 3,Phase 1,Phase 2
35 Adrenergic Agonists Phase 4,Phase 1,Phase 2,Early Phase 1
36 Adrenergic Antagonists Phase 4,Phase 3,Phase 2
37 Adrenergic alpha-Agonists Phase 4,Phase 1,Phase 2,Early Phase 1
38 Sodium Chloride Symporter Inhibitors Phase 4,Phase 3
39 Adrenergic beta-1 Receptor Antagonists Phase 4,Phase 3
40 Adrenergic beta-Antagonists Phase 4,Phase 3,Phase 2,Phase 1
41 Sympatholytics Phase 4,Phase 3
42 Testosterone 17 beta-cypionate Phase 4
43
Testosterone enanthate Phase 4 315-37-7 9416
44 Anabolic Agents Phase 4
45 Hormone Antagonists Phase 4
46 Androgens Phase 4
47 Hormones Phase 4,Phase 1,Phase 2
48 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
49 Vasoconstrictor Agents Phase 4,Phase 1,Phase 2,Early Phase 1
50 Angiotensin II Type 1 Receptor Blockers Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 282)
id Name Status NCT ID Phase
1 Closed Loop Stimulation for Neuromediated Syncope (SPAIN Study) Unknown status NCT01621464 Phase 4
2 Safety of Amiodarone and Ranolazine Together in Patients With Angina Unknown status NCT01558830 Phase 4
3 ISSUE3: International Study on Syncope of Uncertain Etiology 3 Completed NCT00359203 Phase 4
4 Clinical Trial for the Prevention of Vasovagal Syncope Completed NCT00118482 Phase 4
5 ELIAS: Early Loop-Recorder in Suspected Arrhythmogenic Syncope Completed NCT00170261 Phase 4
6 Propranolol to Treat Fainting Due to Sympathoadrenal Imbalance Completed NCT00060866 Phase 4
7 Tilt-Table Study of the Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension Completed NCT01518946 Phase 4
8 Comparision of Blood Pressure Variability Between Amlodipine and Losartan Completed NCT01964079 Phase 4
9 Multicenter Automatic Defibrillator Implantation Trial - Reduce Inappropriate Therapy Completed NCT00947310 Phase 4
10 Programming Implantable Cardioverter Defibrillators in Patients With Primary Prevention Indication Completed NCT00743522 Phase 4
11 Physiologic Evaluation of Anomalous Right Coronary Artery Stenosis Completed NCT01133054 Phase 4
12 Effects of Testosterone on Myocardial Repolarization Completed NCT03126656 Phase 4
13 A Comparison of Polyglactin 910 and Chromic Gut Suture in the Closure of Punch Biopsy Sites Completed NCT01722994 Phase 4
14 Safety, Efficacy and Treatment Satisfaction in Patients With PAH Rapidly Switched From Epoprostenol to Remodulin Completed NCT00373360 Phase 4
15 Assessment of Midodrine in the Prevention of Vasovagal Syncope: The Prevention of Syncope Trial IV Recruiting NCT01456481 Phase 4
16 Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects Recruiting NCT02123056 Phase 4
17 Combining Donepezil With Perceptual Learning in Normal and Amblyopic Human Adults Recruiting NCT03109314 Phase 4
18 Evaluation of PCLs Using Three EUS-FNA Needles Recruiting NCT01711294 Phase 4
19 Syncope: Pacing or Recording in the Later Years Active, not recruiting NCT01423994 Phase 4
20 International Study on Syncope of Uncertain Etiology Terminated NCT00120094 Phase 4
21 A Phase IV Study in Subjects With Neurogenic Orthostatic Hypotension Terminated NCT00046163 Phase 4
22 Rapid Switch From Flolan to Remodulin in the Outpatient Clinic Terminated NCT00643604 Phase 4
23 Safety, Efficacy, and Treatment Satisfaction Switching From Flolan to Remodulin Using the Crono Five Ambulatory Pump in Patients With PAH Terminated NCT00439946 Phase 4
24 Adenosine Testing to DEtermine the Need for Pacing Therapy Unknown status NCT01481168 Phase 3
25 Lactobacillus Reuteri in Treatment of Functional Abdominal Pain and Chronic Constipation in Children Unknown status NCT01587846 Phase 3
26 Stop Vasodepressor Drugs in Reflex Syncope Completed NCT02137278 Phase 3
27 A Two Part Study (306A/306B) to Assess Droxidopa in Treatment of NOH in Patients With Parkinson's Disease Completed NCT01176240 Phase 3
28 Irbesartan/Hydrochlorothiazide (HCTZ) Combination Therapy for Patients With Moderate Hypertension Completed NCT00095550 Phase 3
29 Irbesartan/Hydrochlorothiazide (HCTZ) Combination Therapy as First Line Treatment for Severe Hypertension Completed NCT00095394 Phase 3
30 Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Completed NCT00633880 Phase 3
31 Ablation of Clinical Ventricular Tachycardia Versus Addition of Substrate Ablation on the Long Term Success Rate of VT Ablation Completed NCT01045668 Phase 3
32 Cooperative Studies Program #563 - Prazosin and Combat Trauma PTSD Completed NCT00532493 Phase 3
33 Induction With Foley OR Misoprostol (INFORM) Study Completed NCT01801410 Phase 3
34 Chagas Cardiomyopathy Bisoprolol Intervention Study: Charity Completed NCT00323973 Phase 3
35 Safety/Efficacy Study Comparing the Misoprostol Vaginal Insert to Cervidil for Cervical Ripening and Induction of Labor Completed NCT00308711 Phase 3
36 A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using Droxidopa Completed NCT00782340 Phase 3
37 Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Completed NCT00738062 Phase 3
38 Efficacy of Transcatheter Ablation Using Anatomic Approach of Ganglionated Plexi Located in the Right Atrium to Prevent Neuromediated Cardioinhibitory Syncope Recruiting NCT01814228 Phase 3
39 Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections. Recruiting NCT02809131 Phase 3
40 Efficacy of Implantable Defibrillator Therapy After a Myocardial Infarction Recruiting NCT00673842 Phase 3
41 Effects of PTH Replacement on Bone in Hypoparathyroidism Active, not recruiting NCT00395538 Phase 3
42 Ballooned Intercostal Drain Trial Not yet recruiting NCT03000504 Phase 3
43 Effect of Chronic Oral Hydration in Patients With Recurrent Unexplained Syncope Terminated NCT00143754 Phase 3
44 A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy Terminated NCT01927055 Phase 3
45 Hydroquinidine Versus Placebo in Patients With Brugada Syndrome Terminated NCT00927732 Phase 3
46 Differential Effect of Silodosin Versus Tamsulosin on Stone Clearance After Extra-corporeal Shock Wave Lithotripsy Withdrawn NCT01560091 Phase 3
47 Evaluate the Noninferiority of Medicines Treating Uninfected Pressure Ulcers. Withdrawn NCT02004626 Phase 3
48 Trial Comparing Ablation With Medical Therapy in Patients With Ventricular Tachycardia Withdrawn NCT01798277 Phase 3
49 ASIS for Enbrel in Plaque Psoriasis Unknown status NCT02112097 Phase 1, Phase 2
50 Non-Pharmacologic Therapy for Neurocardiogenic Syncope Completed NCT00096902 Phase 2

Search NIH Clinical Center for Syncope

Genetic Tests for Syncope

Genetic tests related to Syncope:

id Genetic test Affiliating Genes
1 Syncope 29

Anatomical Context for Syncope

MalaCards organs/tissues related to Syncope:

39
Testes, Heart, Brain, Skin, Temporal Lobe, Tongue, Lung

Publications for Syncope

Articles related to Syncope:

(show top 50) (show all 884)
id Title Authors Year
1
The effects of body weight status on orthostatic intolerance and predisposition to noncardiac syncope. ( 28112481 )
2017
2
Post-exercise syncope: Wingate syncope test and visual-cognitive function. ( 27550986 )
2016
3
Searching for the cause of syncope: non-sustained ventricular tachycardia or neurocardiogenic syndrome. Does it really need lengthy investigation? ( 27098073 )
2016
4
A rare cause of syncope in a young female. ( 27567040 )
2016
5
The mechanism of syncope without prodromes with normal heart and normal electrocardiogram. ( 27639455 )
2016
6
Syncope and sudden cardiac death: some answers to clinical challenges. ( 27190173 )
2016
7
Syncope in a 62-year-old man with sarcoidosis. ( 27131072 )
2016
8
Intracardiac Leiomyomatosis - an Unusual Cause of Syncope in a Middle-Aged Woman. ( 27743856 )
2016
9
Syncope and collapse in acute pulmonary embolism. ( 27107684 )
2016
10
Differential effects of ganglionic plexi ablation in a patient with neurally mediated syncope and intermittent atrioventricular block: a commentary. ( 27302390 )
2016
11
Long-Term Outcome of Patients with Bifascicular Block and Unexplained Syncope Following Cardiac Pacing. ( 27565449 )
2016
12
The circadian rhythm of syncopal episodes in patients with neurally mediated syncope. ( 27128529 )
2016
13
Type I Chiari malformation presenting orthostatic syncope who treated with decompressive surgery. ( 28018469 )
2016
14
Syncope in older adults. ( 27594863 )
2016
15
Thrombosis of Inferior Vena Cava Diagnosed Using Point-of-Care Ultrasound After Pediatric Near-Syncope. ( 27545854 )
2016
16
From syncope episode to the diagnosis of ovarian dermoid cyst associated with a cystadenoma. ( 26968295 )
2016
17
Implantable loop recorder versus conventional diagnostic workup for unexplained recurrent syncope. ( 27092427 )
2016
18
The Evaluation of Syncope in a Predominantly Black Population: Focus on Neuroimaging. ( 27583235 )
2016
19
Theophylline and syncope. ( 27537745 )
2016
20
Primary Cardiac Sarcoidosis with Syncope and Refractory Atrial Arrhythmia: A Case Report and Review of the Literature. ( 27303240 )
2016
21
Short term prognosis and current management of syncopal patients at intermediate-risk. Results from the IRiS (Intermediate-Risk Syncope) Study. ( 27178670 )
2016
22
Management of Postural Tachycardia Syndrome, Inappropriate Sinus Tachycardia and Vasovagal Syncope. ( 27617091 )
2016
23
Case 4 - A 67 Year-Old Man with Aortic Regurgitation Who Presented Syncope Followed by Shock. ( 27627642 )
2016
24
Accessory Liver in the Right Atrium: A Rare Cause of Syncope. ( 27549551 )
2016
25
Syncope (Fainting). ( 27142609 )
2016
26
Syncope in an Athlete: a Case of Infectious Mononucleosis-Induced Postural Tachycardia Syndrome. ( 26745170 )
2016
27
Pathophysiological mechanisms of noncardiac syncope in athletes. ( 27606909 )
2016
28
Syncope on a Hot Summer Day. ( 27131612 )
2016
29
Syncope in patients paced for atrioventricular block. ( 26851815 )
2016
30
Beta 3 subunit of G-protein and its influence on autonomic nervous system in patients with vasovagal syncope. ( 26925743 )
2016
31
Recurrent Syncope: An Unusual Complication of Hypertensive Heart Disease. ( 27448490 )
2016
32
Straight Back Syndrome Masquerading as a Mass, with Near-Syncope. ( 27127446 )
2016
33
Stop vasodepressor drugs in reflex syncope: a randomised controlled trial. ( 27664002 )
2016
34
Assessment of endothelin and copeptin as biomarkers for vasovagal syncope. ( 26641207 )
2016
35
Chronic Myeloid Leukemia: A Case of Extreme Thrombocytosis Causing Syncope and Myocardial Infarction. ( 27004153 )
2016
36
Syncope Following Orthotopic Heart Transplant: Sinoatrial or Atrioventricular Nodal Block? ( 27214093 )
2016
37
Genome-Wide Association Study of Copy Number Variations in Patients with Familial Neurocardiogenic Syncope. ( 27156083 )
2016
38
Differential effect of ganglionic plexi ablation in a patient with neurally mediated syncope and intermittent atrioventricular block. ( 27194540 )
2016
39
77-year-old female with syncope. ( 27664004 )
2016
40
Reduced compensatory responses to maintain central blood volume during hypovolemic stress in women with vasovagal syncope. ( 27654398 )
2016
41
The Cost-Effective Evaluation of Syncope. ( 27542422 )
2016
42
Inflammatory myofibroblastic tumor of carotid artery resulting in recurrent syncope: A case report. ( 27028414 )
2016
43
The Current Indication for Pacemaker in Patients with Cardioinhibitory Vasovagal Syncope. ( 27651841 )
2016
44
Self-controllable prodromal symptoms of syncope attributed to carotid sinus syndrome during the end stage of cancer: a case report. ( 27602053 )
2016
45
Syncope: Not for the faint hearted. ( 27189260 )
2016
46
A Male Patient with Syncope, Anaphylaxis, and ST-Elevation: Hepatic and Cardiac Echinococcosis Presenting with Kounis Syndrome. ( 27516403 )
2016
47
Opportunities for Emergency Medical Services (EMS) Care of Syncope. ( 27211803 )
2016
48
Heartbeat: Detection of arrhythmias in older adults with falls and syncope. ( 27073247 )
2016
49
What factors influence parents' perception of the quality of life of children and adolescents with neurocardiogenic syncope? ( 27188269 )
2016
50
Gene Polymorphism of the Adenosine A2a Receptor in Patients with Vasovagal Syncope. ( 26710963 )
2016

Variations for Syncope

Expression for Syncope

Search GEO for disease gene expression data for Syncope.

Pathways for Syncope

Pathways related to Syncope according to GeneCards Suite gene sharing:

(show top 50) (show all 90)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 CALM1 CALM2 CALM3 GNB3 SLC6A2
2
Show member pathways
12.91 CALM1 CALM2 CALM3 GNB3
3
Show member pathways
12.83 CALM1 CALM2 CALM3 GNB3 SCN5A
4
Show member pathways
12.81 CALM1 CALM2 CALM3 GNB3
5
Show member pathways
12.81 CALM1 CALM2 CALM3 GNB3
6
Show member pathways
12.8 CALM1 CALM2 CALM3 GNB3
7
Show member pathways
12.79 CALM1 CALM2 CALM3 GNB3
8
Show member pathways
12.72 CALM1 CALM2 CALM3 KCNJ2 KCNQ1 SCN5A
9
Show member pathways
12.67 CALM1 CALM2 CALM3 GNB3
10
Show member pathways
12.66 CALM1 CALM2 CALM3 GNB3 KCNH2 KCNJ2
11
Show member pathways
12.61 CALM1 CALM2 CALM3 GNB3
12
Show member pathways
12.58 CALM1 CALM2 CALM3 GNB3
13
Show member pathways
12.56 CALM1 CALM2 CALM3 GNB3
14
Show member pathways
12.55 CALM1 CALM2 CALM3 GNB3 KCNJ2 KCNQ1
15
Show member pathways
12.52 CALM1 CALM2 CALM3 GNB3
16
Show member pathways
12.5 CALM1 CALM2 CALM3 GNB3
17
Show member pathways
12.49 CALM1 CALM2 CALM3 GNB3
18
Show member pathways
12.39 CALM1 CALM2 CALM3 GNB3
19
Show member pathways
12.37 CALM1 CALM2 CALM3 GNB3
20
Show member pathways
12.34 CALM1 CALM2 CALM3
21
Show member pathways
12.34 CALM1 CALM2 CALM3
22
Show member pathways
12.32 CALM1 CALM2 CALM3
23
Show member pathways
12.31 CALM1 CALM2 CALM3
24
Show member pathways
12.3 CALM1 CALM2 CALM3 GNB3
25
Show member pathways
12.29 CALM1 CALM2 CALM3
26
Show member pathways
12.29 CALM1 CALM2 CALM3 KCNH2 KCNJ2 KCNQ1
27
Show member pathways
12.28 CALM1 CALM2 CALM3
28
Show member pathways
12.26 CALM1 CALM2 CALM3
29
Show member pathways
12.26 CALM1 CALM2 CALM3
30
Show member pathways
12.25 CALM1 CALM2 CALM3
31
Show member pathways
12.24 CALM1 CALM2 CALM3 GNB3
32
Show member pathways
12.23 CALM1 CALM2 CALM3
33
Show member pathways
12.23 CALM1 CALM2 CALM3 GNB3
34
Show member pathways
12.19 CALM1 CALM2 CALM3
35
Show member pathways
12.17 CALM1 CALM2 CALM3
36 12.17 CALM1 CALM2 CALM3
37
Show member pathways
12.15 CALM1 CALM2 CALM3
38 12.15 GNB3 KCNH2 KCNQ1 SCN5A
39
Show member pathways
12.14 CALM1 CALM2 CALM3
40
Show member pathways
12.14 CALM1 CALM2 CALM3 GNB3
41
Show member pathways
12.11 CALM1 CALM2 NPPA
42
Show member pathways
12.11 CALM1 CALM2 CALM3 GNB3
43
Show member pathways
12.07 CALM1 CALM2 CALM3
44
Show member pathways
12.07 GNB3 KCNH2 KCNJ2 KCNQ1
45 12.05 CALM1 CALM2 CALM3
46 12.02 CALM1 CALM2 CALM3 GNB3
47
Show member pathways
11.96 CALM1 CALM2 CALM3
48
Show member pathways
11.95 CALM1 CALM2 CALM3
49
Show member pathways
11.94 CALM1 CALM2 CALM3 KCNJ2 KCNQ1
50
Show member pathways
11.92 CALM1 CALM2 CALM3

GO Terms for Syncope

Cellular components related to Syncope according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.91 CALM1 CALM2 CALM3 GNB3 KCNH2 KCNJ2
2 spindle GO:0005819 9.61 CALM1 CALM2 CALM3
3 vesicle GO:0031982 9.58 CALM1 CALM2 CALM3
4 spindle pole GO:0000922 9.54 CALM1 CALM2 CALM3
5 voltage-gated potassium channel complex GO:0008076 9.5 KCNH2 KCNJ2 KCNQ1
6 T-tubule GO:0030315 9.46 KCNJ2 SCN5A
7 sarcomere GO:0030017 9.33 CALM1 CALM2 CALM3
8 spindle microtubule GO:0005876 9.13 CALM1 CALM2 CALM3
9 calcium channel complex GO:0034704 8.8 CALM1 CALM2 CALM3

Biological processes related to Syncope according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
id Name GO ID Score Top Affiliating Genes
1 regulation of ion transmembrane transport GO:0034765 9.96 KCNH2 KCNJ2 KCNQ1 SCN5A
2 Fc-epsilon receptor signaling pathway GO:0038095 9.89 CALM1 CALM2 CALM3
3 potassium ion transport GO:0006813 9.88 KCNH2 KCNJ2 KCNQ1
4 potassium ion transmembrane transport GO:0071805 9.88 KCNH2 KCNJ2 KCNQ1
5 platelet degranulation GO:0002576 9.88 CALM1 CALM2 CALM3
6 muscle contraction GO:0006936 9.87 CALM1 CALM2 CALM3
7 response to calcium ion GO:0051592 9.85 CALM1 CALM2 CALM3
8 inositol phosphate metabolic process GO:0043647 9.85 CALM1 CALM2 CALM3
9 cardiac muscle contraction GO:0060048 9.84 KCNH2 KCNQ1 SCN5A
10 substantia nigra development GO:0021762 9.84 CALM1 CALM2 CALM3
11 protein methylation GO:0006479 9.83 CALM1 CALM2 CALM3
12 positive regulation of protein serine/threonine kinase activity GO:0071902 9.83 CALM1 CALM2 CALM3
13 Wnt signaling pathway, calcium modulating pathway GO:0007223 9.82 CALM1 CALM2 CALM3
14 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.82 CALM1 CALM2 CALM3
15 regulation of rhodopsin mediated signaling pathway GO:0022400 9.81 CALM1 CALM2 CALM3
16 regulation of nitric-oxide synthase activity GO:0050999 9.81 CALM1 CALM2 CALM3
17 positive regulation of protein autophosphorylation GO:0031954 9.8 CALM1 CALM2 CALM3
18 regulation of cytokinesis GO:0032465 9.8 CALM1 CALM2 CALM3
19 regulation of cardiac muscle contraction GO:0055117 9.79 CALM1 CALM2 CALM3
20 positive regulation of protein dephosphorylation GO:0035307 9.79 CALM1 CALM2 CALM3
21 glycogen catabolic process GO:0005980 9.78 CALM1 CALM2 CALM3
22 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.77 CALM1 CALM2 CALM3
23 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.77 CALM1 CALM2 CALM3
24 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.76 KCNH2 KCNQ1 SCN5A
25 positive regulation of potassium ion transmembrane transport GO:1901381 9.75 KCNH2 KCNJ2 KCNQ1
26 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.74 CALM1 CALM2 CALM3
27 ventricular cardiac muscle cell action potential GO:0086005 9.73 KCNH2 KCNQ1 SCN5A
28 cardiac conduction GO:0061337 9.73 KCNH2 KCNJ2 KCNQ1 SCN5A
29 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.72 CALM1 CALM2 CALM3
30 membrane depolarization during action potential GO:0086010 9.71 KCNH2 SCN5A
31 positive regulation of heart rate GO:0010460 9.71 KCNQ1 NPPA
32 detection of calcium ion GO:0005513 9.71 CALM1 CALM2 CALM3
33 cardiac muscle cell action potential involved in contraction GO:0086002 9.7 KCNJ2 SCN5A
34 regulation of cardiac muscle cell contraction GO:0086004 9.7 KCNJ2 SCN5A
35 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.7 KCNJ2 SCN5A
36 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.7 CALM1 CALM2 CALM3
37 atrial cardiac muscle cell action potential GO:0086014 9.69 KCNQ1 SCN5A
38 potassium ion export GO:0071435 9.69 KCNH2 KCNQ1
39 regulation of membrane repolarization GO:0060306 9.69 KCNH2 KCNJ2 KCNQ1
40 positive regulation of cardiac muscle contraction GO:0060452 9.68 KCNQ1 NPPA
41 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.68 KCNH2 KCNQ1
42 regulation of high voltage-gated calcium channel activity GO:1901841 9.68 CALM1 NPPA
43 potassium ion export across plasma membrane GO:0097623 9.67 KCNH2 KCNQ1
44 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.67 KCNH2 KCNJ2 KCNQ1
45 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.65 CALM1 CALM2 CALM3
46 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.63 CALM1 CALM2 CALM3
47 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.58 KCNQ1 NPPA SCN5A
48 regulation of heart rate by cardiac conduction GO:0086091 9.56 KCNH2 KCNJ2 KCNQ1 SCN5A
49 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.54 CALM1 CALM2 CALM3
50 membrane repolarization during action potential GO:0086011 9.5 KCNH2 KCNJ2 KCNQ1

Molecular functions related to Syncope according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.86 CALM1 CALM2 CALM3 SCN5A
2 protein domain specific binding GO:0019904 9.83 CALM1 CALM2 CALM3 SCN5A
3 voltage-gated ion channel activity GO:0005244 9.78 KCNH2 KCNJ2 KCNQ1 SCN5A
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.72 CALM1 CALM2 CALM3
5 scaffold protein binding GO:0097110 9.69 KCNH2 KCNQ1 SCN5A
6 ligand-gated ion channel activity GO:0015276 9.67 CALM1 CALM2 CALM3
7 protein serine/threonine kinase activator activity GO:0043539 9.63 CALM1 CALM2 CALM3
8 phospholipase binding GO:0043274 9.61 CALM1 CALM2 CALM3
9 inward rectifier potassium channel activity GO:0005242 9.58 KCNH2 KCNJ2
10 delayed rectifier potassium channel activity GO:0005251 9.58 KCNH2 KCNQ1
11 titin binding GO:0031432 9.58 CALM1 CALM2 CALM3
12 nitric-oxide synthase binding GO:0050998 9.57 CALM1 SCN5A
13 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 9.54 KCNH2 KCNQ1
14 thioesterase binding GO:0031996 9.54 CALM1 CALM2 CALM3
15 inositol-1,4,5-trisphosphate 3-kinase activity GO:0008440 9.5 CALM1 CALM2 CALM3
16 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 9.43 KCNH2 KCNJ2 KCNQ1
17 ion channel binding GO:0044325 9.35 CALM1 CALM2 CALM3 KCNQ1 SCN5A
18 protein phosphatase activator activity GO:0072542 9.33 CALM1 CALM2 CALM3
19 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3

Sources for Syncope

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....