Aliases & Classifications for Syncope

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Syncope, Aliases & Descriptions:

Name: Syncope 42 3


Summaries for Syncope

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NINDS:42 Syncope is a medical term used to describe a temporary loss of consciousness due to the sudden decline of blood flow to the brain. Syncope is commonly called fainting or ?passing out.? If an individual is about to faint, he or she will feel dizzy, lightheaded, or nauseous and their field of vision may ?white out? or ?black out.?

MalaCards based summary: Syncope is related to orthostatic intolerance and atrioventricular block. An important gene associated with Syncope is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are Sympathetic Nerve Pathway (Neuroeffector Junction) and Ca, cAMP and Lipid Signaling. The compounds pseudoephedrine and desipramine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and heart, and related mouse phenotypes are muscle and cardiovascular system.

Wikipedia:63 Syncope may refer to one of the following: more...

Related Diseases for Syncope

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Diseases related to Syncope via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 204)
idRelated DiseaseScoreTop Affiliating Genes
1orthostatic intolerance31.3SLC6A2
2atrioventricular block31.1NKX2-5
3brugada syndrome30.4SCN4B, KCNE2
4long qt syndrome30.3SCN4B, KCNE2
5familial atrial fibrillation30.2KCNE2
6hypertrophic cardiomyopathy30.2TCAP, PLN, CALR3
7coronary artery disease29.9ADRB1, SLC6A2
8congenital heart block29.6SCN4B, KCNE2
9glossopharyngeal neuralgia10.6
10fainting10.5
11sick sinus syndrome10.4
12generalized anxiety disorder10.4SLC6A2
13syncope, familial vasovagal10.4
14catecholaminergic polymorphic ventricular tachycardia10.4
15postural orthostatic tachycardia syndrome10.4
16ventricular extrasystoles with syncopal episodes - perodactyly - robin sequence10.3
17cerebritis10.3
18pulmonary embolism10.2
19left ventricular outflow tract obstruction10.2
20migraine10.2
21postural hypotension10.2
22wolff-parkinson-white syndrome10.1
23ventricular tachycardia, catecholaminergic polymorphic, 110.1
24jervell and lange-nielsen syndrome10.1
25temporal lobe epilepsy10.1
26myocarditis10.1
27cor triatriatum10.1
28mastocytosis10.1
29hypertension, essential10.1SLC6A2, ADRB1
30long qt syndrome 110.1
31systemic mastocytosis10.1
32pharyngitis10.1
33constrictive pericarditis10.1
34subclavian steal syndrome10.1
35atrial fibrillation10.1
36dementia10.1
37esophagitis10.1
38hypothyroidism10.1
39pericarditis10.1
40exercise induced anaphylaxis10.1
41prinzmetal's variant angina10.1
42autonomic dysfunction10.1
43dysautonomia10.1
44panic disorder10.1RGS2, SLC6A2
45cardiac arrhythmia, ankyrin-b-related10.0
46long qt syndrome 210.0
47long qt syndrome 1310.0
48nasopharyngeal carcinoma10.0
49long qt syndrome 1210.0
50long qt syndrome 610.0

Graphical network of the top 20 diseases related to Syncope:



Diseases related to syncope

Symptoms for Syncope

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Drugs & Therapeutics for Syncope

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Drug clinical trials:

Search ClinicalTrials for Syncope

Search NIH Clinical Center for Syncope

Genetic Tests for Syncope

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Anatomical Context for Syncope

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MalaCards organs/tissues related to Syncope:

31
Testes, Brain, Heart, Temporal lobe, Tongue, Lung, Thyroid, Bone, Whole blood, Skin, Prostate, B cells, Endothelial, Atrioventricular node

Animal Models for Syncope or affiliated genes

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MGI Mouse Phenotypes related to Syncope:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.9ADRB1, TCAP, PLN, NKX2-5, RGS2
2MP:00053857.8SLC6A2, RGS2, NKX2-5, PLN, TCAP, ADRB1
3MP:00053767.7SLC6A2, NKX2-5, PLN, TCAP, ADRB1, KCNE2

Publications for Syncope

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Articles related to Syncope:

(show top 50)    (show all 791)
idTitleAuthorsYear
1
What is The Utility of Electrophysiological Study in Elderly Patients with Syncope and Heart Disease? (25852241)
2015
2
The "syncope and dementia" study: a prospective, observational, multicenter study of elderly patients with dementia and episodes of "suspected" transient loss of consciousness. (25820493)
2015
3
Heart rate variability analysis during head-up tilt test predicts nitroglycerine-induced syncope. (25332802)
2014
4
Far-field ventricular sensing defects and syncope in a patient with right subclavian VDD pace-maker. (25304074)
2014
5
'Um, I think she just died'. Carefully evaluate & monitor all patients with syncope. (25322513)
2014
6
Cardiac Autonomic Dysfunction in Patients with Head-up Tilt Test-Induced Vasovagal Syncope. (25139789)
2014
7
Near-infrared diffuse optical monitoring of cerebral blood flow and oxygenation for the prediction of vasovagal syncope. (24402372)
2014
8
Syncope secondary to second-degree atrioventricular block with donepezil use. (25484499)
2014
9
Postexercise syncope: Wingate syncope test and effective countermeasure. (24078670)
2014
10
Malignant cardioinhibitory vasovagal syncope - an uncommon cardiovascular complication of Roux-en-Y gastric bypass surgery: the fainting syndrome! (23063207)
2013
11
Accuracy of the ICD-10 discharge diagnosis for syncope. (23129545)
2013
12
Prognostic value of the OESIL risk score in a cohort of Emergency Department patients with syncope. (24008603)
2013
13
Prevalence of fibromyalgia in vasovagal syncope. (23519175)
2013
14
The San Francisco Syncope Rule performs well in a regional rural emergency department in New Zealand. (23799380)
2013
15
Value of history taking in children and adolescents with cardiac syncope. (22417947)
2013
16
Percutaneous atrial septostomy with modified butterfly stent and intracardiac echocardiographic guidance in a patient with syncope and refractory pulmonary arterial hypertension. (23402682)
2013
17
Re: age-related prognosis of syncope associated with a preexcitation syndrome. (23713681)
2013
18
Postural orthostatic tachycardia syndrome, neurally-mediated syncope, and joint hypermobility: a case report. (23490229)
2013
19
Syncope associated with documented paroxysmal atrioventricular block reproduced by adenosine 5' triphosphate injection. (24128810)
2013
20
Atrial Electromechanical Conduction Delay in Patients with Neurocardiogenic Syncope. (24215448)
2013
21
Vasovagal syncope: new physiologic insights. (23217689)
2013
22
Treatment of neurally mediated reflex syncope. (23217693)
2013
23
Predictors of vasovagal syncope recurrence in children and adolescents and value of head-up tilt table test. (23996804)
2013
24
Pearls & Oy-sters: ictal syncope in a patient with temporal lobe epilepsy. (24325018)
2013
25
Medical therapy and physical maneuvers in the treatment of the vasovagal syncope and orthostatic hypotension. (23472781)
2013
26
Recurrent orthostatic syncope due to left atrial and left ventricular collapse after a continuous-flow left ventricular assist device implantation. (23260713)
2013
27
Acute right ventricular myocarditis presenting with chest pain and syncope. (24096068)
2013
28
Asystole due to head scratching: a newly confirmed situational syncope. (23872689)
2013
29
Recurrent syncope: a slow heart rate? (23864482)
2013
30
Pearls & Oy-sters: ictal syncope in a patient with temporal lobe epilepsy. (24166964)
2013
31
Nutcracker syndrome: symptoms of syncope and hypotension improved following endovascular stenting. (22734085)
2012
32
Letter by Lagro et al regarding article, "Treatment of unexplained syncope: a multicenter, randomized trial of cardiac pacing guided by adenosine 5'-triphosphate testing". (22908021)
2012
33
Syncope in a patient being treated for hepatic and intestinal amoebiasis. (23203174)
2012
34
Sensitive troponin assay predicts outcome in syncope. (22962048)
2012
35
Defining abnormal electrocardiography in adult emergency department syncope patients: the Ottawa Electrocardiographic Criteria. (22813399)
2012
36
A rare cause of syncope: cough. (22582489)
2012
37
Syncope: evaluation and management in the geriatric patient. (23101580)
2012
38
Positive result in the early passive phase of the tilt-table test: a predictor of neurocardiogenic syncope in young men. (22403501)
2012
39
Syncope. (22032666)
2011
40
Vasovagal syncope as a cause of syncope in long-QT syndrome. (21718921)
2011
41
Mild hyperkalemia and low eGFR a tedious recipe for cardiac disaster in the elderly: an unusual reversible cause of syncope and heart block. (22049311)
2011
42
Neurally mediated syncope associated with small cell lung cancer: a case report and review. (22001467)
2011
43
Syncope in cardiac amyloidosis and chronic ischemic heart disease: A case report. (21747665)
2011
44
Risk of syncope in family members who are genotype-negative for a family-associated long-QT syndrome mutation. (21831960)
2011
45
Syncope and QT prolongation among patients treated with methadone for heroin dependence in the city of Copenhagen. (17344330)
2007
46
Catecholaminergic polymorphic ventricular tachycardia, recurrent syncope, and implantable loop recorder. (15175074)
2004
47
Neurocardiogenic syncope and Prinzmetal's angina associated with bronchogenic carcinoma. (9118728)
1997
48
Role of endogenous opioids and catecholamines in vasovagal syncope. (8922923)
1996
49
Syncope caused by carotid body tumor. (9046120)
1996
50
Immunoblastic lymphoma presenting with syncope due to sinoatrial node disease. (2371193)
1990

Variations for Syncope

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Expression for genes affiliated with Syncope

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Search GEO for disease gene expression data for Syncope.

Pathways for genes affiliated with Syncope

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Pathways related to Syncope according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SLC6A2, ADRB1
29.6PLN, ADRB1
3
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy36
9.6PLN, ADRB1
4
Show member pathways
Development Beta adrenergic receptors regulation of ERK58
G protein signaling G Protein alpha s signaling cascades58
G protein signaling G Protein beta gamma signaling cascades58
9.5ADRB1, RGS2
5
Show member pathways
9.3ADRB1, KCNE2
6
Show member pathways
Calcium Regulation in the Cardiac Cell36
9.1ADRB1, PLN, RGS2
78.8SCN4B, ADRB1, PLN
8
Show member pathways
8.3RGS2, PLN, ADRB1, SCN4B
98.1PLN, ADRB1, SCN4B, KCNE2

Compounds for genes affiliated with Syncope

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Sources:
43Novoseek, 24HMDB, 12DrugBank, 49PharmGKB
See all sources

Compounds related to Syncope according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1pseudoephedrine43 24 1211.7ADRB1, SLC6A2
2desipramine43 49 1211.7SLC6A2, ADRB1
3catecholamine439.6SLC6A2, ADRB1
4forskolin43 49 1211.1SLC6A2, RGS2, ADRB1
5adenylate438.9ADRB1, RGS2, SLC6A2
6calcium43 49 24 1211.5ADRB1, PLN, CALR3, RGS2, SLC6A2
7sodium43 249.3SLC6A2, ADRB1, SCN4B, KCNE2

GO Terms for genes affiliated with Syncope

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Biological processes related to Syncope according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1relaxation of cardiac muscleGO:00551199.9RGS2, PLN
2regulation of cardiac muscle cell contractionGO:00860049.8ADRB1, PLN
3cardiac muscle tissue morphogenesisGO:00550089.7NKX2-5, TCAP
4adult heart developmentGO:00075129.7TCAP, NKX2-5
5regulation of calcium ion transportGO:00519249.6ADRB1, PLN
6sarcomere organizationGO:00452149.4TCAP, NKX2-5
7positive regulation of sodium ion transportGO:00107659.4NKX2-5, SCN4B
8agingGO:00075689.3ADRB1, KCNE2
9cardiac muscle cell action potential involved in contractionGO:00860029.3KCNE2, SCN4B
10regulation of ventricular cardiac muscle cell membrane repolarizationGO:00603079.2SCN4B, KCNE2
11brown fat cell differentiationGO:00508739.2RGS2, ADRB1
12regulation of heart rate by cardiac conductionGO:00860919.1SCN4B, KCNE2
13cardiac muscle contractionGO:00600489.0NKX2-5, TCAP, SCN4B

Molecular functions related to Syncope according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1beta-tubulin bindingGO:00484879.7SLC6A2, RGS2
2ion channel bindingGO:00443258.2TCAP, SCN4B, KCNE2

Products for genes affiliated with Syncope

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Sources for Syncope

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet