MCID: SYN036
MIFTS: 49

Syncope malady

Summaries for Syncope

Sources:
3CDC, 44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Syncope is a medical term used to describe a temporary loss of consciousness due to the sudden decline of blood flow to the brain. Syncope is commonly called fainting or ?passing out.? If an individual is about to faint, he or she will feel dizzy, lightheaded, or nauseous and their field of vision may ?white out? or ?black out.?

MalaCards: Syncope is related to orthostatic intolerance and hypertrophic cardiomyopathy. An important gene associated with Syncope is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are Adrenoceptors and Cardiomyocyte Differentiation through BMP Receptors. The compounds n-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide and pseudoephedrine have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and heart, and related mouse phenotypes are respiratory system and muscle.

CDC:3 On October 25, 2007, updated information about syncope reports to the Vaccine Adverse Event Reporting System (VAERS) from January 1, 2005 through July 31, 2007 was presented to the Advisory Committee on Immunization Practices (ACIP). The committee was also reminded about the current ACIP recommendations to prevent syncope and its related sequelae from occurring after vaccination.

Wikipedia:64 Syncope may refer to one of the following: more...

Aliases & Classifications for Syncope

Sources:
44NINDS
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Aliases & Descriptions:

syncope 44


Related Diseases for Syncope

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Syncope via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1orthostatic intolerance30.7SLC6A2
2hypertrophic cardiomyopathy30.2TNNI3, MYL2, MYL3
3familial atrial fibrillation29.7KCNE2, GATA5
4acute myocardial infarction29.7MYL3, ADRB1, TNNI3
5glossopharyngeal neuralgia10.6
6fainting10.5
7n syndrome10.4
8sick sinus syndrome10.4
9brugada syndrome10.4
10postural orthostatic tachycardia syndrome10.3
11atrioventricular block10.3
12familial neurocardiogenic syncope10.3
13ventricular extrasystoles with syncopal episodes - perodactyly - robin sequence10.2
14catecholaminergic polymorphic ventricular tachycardia10.2
15postural hypotension10.2
16carotid body tumor10.2
17left ventricular outflow tract obstruction10.2
18wolff-parkinson-white syndrome10.1
19temporal lobe epilepsy10.1
20mastocytosis10.1
21autonomic dysfunction10.1
22subclavian steal syndrome10.1
23jervell-lange nielsen syndrome10.1
24constrictive pericarditis10.1
25systemic mastocytosis10.1
26exercise induced anaphylaxis10.1
27paroxysmal ventricular fibrillation10.1
28mass syndrome10.1
29prinzmetal's variant angina10.1
30ventricular tachycardia, catecholaminergic polymorphic, 110.1
31congestive heart failure10.0TNNI3
32familial restrictive cardiomyopathy10.0TNNI3
33myopathy10.0TNNI3, TCAP
34dilated cardiomyopathy10.0ADRB1, TCAP, TNNI3, PLN
35hypertension10.0RGS2, KCNA5, GNB3, ADRB1
36familial hypertrophic cardiomyopathy10.0TCAP, MYLK2
37long qt syndrome10.0KCNJ2, KCNE2, KCNA5, SCN4B
38sudden cardiac death multi-gene panels10.0ADRB1, KCNE2, KCNJ2
39noonan syndrome10.0ADRB1, TNNI3, MYL2, NKX2-5, PLN, TCAP
40hypertrophy of breast10.0MYL2, GNB3, PLN, RGS2, ADRB1
41ischemia10.0ADORA2A, SLC6A2
42essential hypertension10.0ADRB1, GNB3, SLC6A2, ADORA2A
43congenital heart defect10.0GJA5
44myocardial infarction10.0TNNI3, ADRB1, GNB3, MYL3
45anorexia nervosa10.0SLC6A2
46panic disorder10.0ADORA2A, SLC6A2, RGS2
47generalized anxiety disorder10.0SLC6A2
48coronary artery disease,10.0
49primary pulmonary hypertension10.0
50mitral valve prolapse10.0

Graphical network of the top 20 diseases related to Syncope:



Diseases related to syncope

Clinical Features for Syncope

Drugs & Therapeutics for Syncope

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Syncope

Drug clinical trials:

Search ClinicalTrials for Syncope

Search NIH Clinical Center for Syncope

Search CenterWatch for Syncope

Genetic Tests for Syncope

Anatomical Context for Syncope

Sources:
33MalaCards
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MalaCards organs/tissues related to Syncope:

33
Whole blood, Brain, Heart, Small intestine, Lung, Thyroid, Skin, Prostate, T cells, B lymphoblasts, B cells, Endothelial, Temporal lobe, Occipital lobe, Atrioventricular node, Tongue

Animal Models for Syncope or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Syncope

Sources:
51PubMed
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Articles related to Syncope:

(show top 50)    (show all 728)
idTitleAuthorsYear
1
Driving Policy after Seizures and Unexplained Syncope: A Practice Guide for RI Physicians. (24400312)
2014
2
Prognostic value of the OESIL risk score in a cohort of Emergency Department patients with syncope. (24008603)
2013
3
Prevalence of fibromyalgia in vasovagal syncope. (23519175)
2013
4
Treatment of neurally mediated reflex syncope. (23217693)
2013
5
Predictors of vasovagal syncope recurrence in children and adolescents and value of head-up tilt table test. (23996804)
2013
6
Syncope with atypical trunk convulsions in a patient with malignant arrhythmia. (23774850)
2013
7
Does the absence of comorbidities really identify low-risk syncope patients? (23542104)
2013
8
Psychological correlates of vasovagal versus medically unexplained syncope. (23415579)
2013
9
Laughter-induced syncope. (23861284)
2013
10
Approach to syncope and altered mental status. (24093897)
2013
11
Syncope for phlebologists. (23761878)
2013
12
Recurrent syncope in the young: do not forget the coronary arteries. (23076782)
2013
13
Prevalence of family history in patients with reflex syncope. (23477874)
2013
14
Syncope in High-Risk Cardiomyopathy Patients with Implantable Defibrillators: Frequency, Risk Factors, Mechanisms and Association with Mortality: Results from the MADIT-RIT Study. (24201303)
2013
15
Syncope in Children Caused by Hair Grooming: Clinical Characteristics in 12 New Cases. (23682042)
2013
16
Syncope in Brugada syndrome type 3: an electrocardiographic lesson. (23380116)
2013
17
Syncope during boceprevir treatment in hepatitis C. (24018506)
2013
18
Neurocardiogenic syncope of child dental patient: a case review. (23635903)
2013
19
Evaluation of the CHADS2 risk score on short- and long-term all-cause and cardiovascular mortality after syncope. (23450502)
2013
20
A Case of Sinus Arrest and Post-hiccup Cough Syncope in Medullary Infarction. (23660345)
2013
21
Clinical impact of the implantable loop recorder in patients with isolated syncope, bundle branch block and negative workup: a randomized multicentre prospective study. (23582676)
2013
22
Recurrent syncope on effort due to concealed constrictive pericarditis. (22711756)
2013
23
Syncope: evaluation and management in the geriatric patient. (23101580)
2012
24
Extradural, retro-orbital, arteriovenous malformation as the cause of a long-term history of syncope. (23192582)
2012
25
Exercise-induced anaphylaxis as a cause of syncope. (20864290)
2012
26
Case 2: 'I feel faint': An adolescent with recurrent dizziness and syncope. (23730166)
2012
27
The relation between age, sex, comorbidity, and pharmacotherapy and the risk of syncope: a Danish nationwide study. (22588456)
2012
28
A case of swallow syncope associated with cold beverage ingestion. (22493619)
2012
29
Vasomotor reactivity as a predictor for syncope in patients with orthostatism. (21916853)
2012
30
Ganglionated plexi ablation in right atrium to treat cardioinhibitory neurocardiogenic syncope. (22434334)
2012
31
Carotid artery stiffness in patients with neurally mediated syncope. (22922623)
2012
32
Syncope or seizure? The diagnostic value of synchronous tilt testing and video-EEG monitoring in children with transient loss of consciousness. (22459868)
2012
33
T-peak to T-end abnormality in pediatric patients with syncope. (23400391)
2012
34
Risk of syncope in family members who are genotype-negative for a family-associated long-QT syndrome mutation. (21831960)
2011
35
Electrophysiological features in patients with sinus node dysfunction and vasovagal syncope. (22328878)
2011
36
Syncope revealing a ruptured sacral dermoid cyst in an 84-year-old man: case report. (21968592)
2011
37
Endothelin system polymorphisms in tilt test-induced vasovagal syncope. (19367425)
2009
38
Recurrent syncope due to carotid sinus hypersensitivity and sick sinus syndrome. (18955189)
2008
39
Role of brain natriuretic peptide (BNP) in risk stratification of adult syncope. (17954830)
2007
40
Cardiac ryanodine receptor gene (hRyR2) mutation underlying catecholaminergic polymorphic ventricular tachycardia in a Chinese adolescent presenting with sudden cardiac arrest and cardiac syncope. (17199967)
2006
41
Syncope and orthostatic intolerance for the primary care physician. (15110165)
2004
42
Central serotonergic responsiveness in neurocardiogenic syncope: a clomipramine test challenge. (9851959)
1998
43
Recurrent neurocardiogenic syncope in a patient with sick sinus syndrome. (7875710)
1994
44
Glossopharyngeal neuralgia and syncope secondary to neck malignancy. (8445696)
1993
45
Naloxone does not prevent vasovagal syncope during simulated orthostasis in humans. (8227960)
1993
46
Incidence and predictors of syncope in paced patients with sick sinus syndrome. (1279599)
1992
47
Glossopharyngeal neuralgia associated with cardiac syncope: long term treatment with permanent pacing and carbamazepine. (2271351)
1990
48
Cough syncope caused by sinus arrest in a patient with sick sinus syndrome. (2472614)
1989
49
Glossopharyngeal neuralgia with syncope. (435778)
1979
50
Fainting (syncope), with particular reference to breath-holding spells in young children. (4170503)
1968

Genetic Variations for Syncope

Expression for genes affiliated with Syncope

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Syncope

Search GEO for disease gene expression data for Syncope.

Pathways for genes affiliated with Syncope

Sources:
54Reactome, 50PharmGKB, 52QIAGEN, 12EMD Millipore, 38NCBI BioSystems Database, 4Cell Signaling Technology, 30KEGG
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Pathways related to Syncope according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4ADRB1, SLC6A2
210.4MYL2, NKX2-5
3
G-protein signaling G-Protein alpha-i signaling cascades
Hide members
10.4ADRB1, RGS2, GNB3
4
Hide members
10.4MYL3, MYLK2, GNB3
5
Hide members
10.4KCNA5, KCNJ2, GNB3
610.3MYL2, NKX2-5, TNNI3
710.3KCNA5, KCNE2, KCNJ2, GNB3
8
Hide members
10.3GNB3, MYLK2, MYL3, PLN
910.3ADRB1, PLN, TNNI3, GNB3
10
Immune response CCR3 signaling in eosinophils
Hide members
10.3GNB3, MYL2, MYLK2, MYL3
11
Hide members
10.3TNNI3, TNNC1, PLN, ADRB1
12
Hide members
10.3KCNE2, KCNJ2, MYLK2, ADRB1
1310.3TNNI3, TNNC1, MYL2, MYL3
1410.3TNNC1, MYLK2, PLN, ADRB1, ADORA2A
15
Hide members
10.2TNNI3, TNNC1, MYL2, MYL3, TCAP
16
Hide members
10.2TNNI3, TNNC1, MYL2, MYL3, PLN, ADRB1
17
Hide members
10.2GNB3, MYL2, MYLK2, GJA5, PLN, RGS2
1810.2ADRB1, KCNA5, KCNE2, KCNJ2, SCN4B, GJA5
19
Hide members
10.1GNB3, TNNI3, SCN4B, MYL2, MYL3, PLN

Compounds for genes affiliated with Syncope

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Syncope according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1n-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide45 1111.7TNNC1, TNNI3
2pseudoephedrine45 11 2412.7SLC6A2, ADRB1
3Droxidopa1110.6ADRB1, SLC6A2
4Ephedra1110.6ADRB1, SLC6A2
5sibutramine45 1111.6SLC6A2, GNB3
6amine4510.6KCNJ2, SLC6A2, ADORA2A
7sodium45 2411.5KCNE2, GNB3, SCN4B, GJA5, SLC6A2, ADRB1
8forskolin45 50 1112.5ADRB1, RGS2
9nitric oxide45 11 2412.5GNB3, NKX2-5, MYLK2, GJA5, ADRB1, ADORA2A
10norepinephrine45 11 2412.5GNB3, SLC6A2, ADRB1, ADORA2A
11quinpirole45 2911.5ADORA2A, RGS2
12potassium45 11 2412.4KCNA5, KCNE2, KCNJ2, GNB3, TNNI3, MYL2
13(r)-(+)-blebbistatin6010.4MYL3, MYL2
14(+-)-blebbistatin6010.4MYL2, MYL3
15bts6010.3MYL2, MYL3
16calcium45 50 11 2413.2ADORA2A, KCNA5, KCNJ2, CALR3, TNNI3, TNNC1
17(s)-(-)-blebbistatin6010.1MYL2, MYL3

GO Terms for genes affiliated with Syncope

Sources:
16Gene Ontology
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Cellular components related to Syncope according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1I bandGO:03167410.4TCAP, MYL3
2sarcomereGO:03001710.4MYL3, MYLK2, MYL2, TNNI3
3intercalated discGO:01470410.3GJA5, SCN4B, KCNA5
4troponin complexGO:00586110.3TNNI3, TNNC1
5voltage-gated potassium channel complexGO:00807610.0KCNJ2, KCNE2, KCNA5

Biological processes related to Syncope according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1cardiac conduction system developmentGO:00316110.8GJA5, NKX2-5
2cardiac muscle tissue morphogenesisGO:05500810.7NKX2-5, MYLK2, TCAP
3membrane repolarization involved in regulation of action potentialGO:08601110.7KCNJ2, KCNE2
4relaxation of cardiac muscleGO:05511910.7KCNJ2, PLN, RGS2
5negative regulation of ATPase activityGO:03278010.7TNNI3, PLN
6membrane depolarization involved in regulation of cardiac muscle cell action potentialGO:08601210.7SCN4B, KCNJ2
7regulation of cardiac muscle cell action potential involved in contractionGO:08600210.7SCN4B, KCNJ2, KCNE2
8potassium ion importGO:01010710.7KCNE2, KCNJ2
9regulation of ventricular cardiac muscle cell membrane repolarizationGO:06030710.7GJA5, SCN4B, KCNE2
10regulation of inhibitory postsynaptic membrane potentialGO:06008010.7ADORA2A, ADRB1
11regulation of calcium ion transportGO:05192410.7PLN, ADRB1, ADORA2A
12potassium ion exportGO:07143510.7KCNA5, KCNE2
13regulation of atrial cardiac muscle cell action potentialGO:08601410.7KCNA5, GJA5
14regulation of cardiac muscle cell contractionGO:08600410.7PLN, ADRB1
15atrial septum morphogenesisGO:06041310.7NKX2-5, GJA5
16ventricular cardiac muscle tissue morphogenesisGO:05501010.7MYL3, MYL2, TNNC1, TNNI3
17regulation of membrane repolarizationGO:06030610.7KCNE2, KCNJ2
18regulation of striated muscle contractionGO:00694210.7MYL2, MYL3
19regulation of heart rate by cardiac conductionGO:08609110.6KCNA5, KCNE2, KCNJ2, SCN4B, GJA5
20muscle filament slidingGO:03004910.6TNNI3, TNNC1, MYL2, MYL3, TCAP
21heart contractionGO:06004710.6TNNI3, MYL2
22cardiac myofibril assemblyGO:05500310.6TCAP, MYL2
23regulation of cardiac muscle contractionGO:05511710.6NKX2-5, GJA5
24adult heart developmentGO:00751210.6TCAP, NKX2-5
25embryonic heart tube developmentGO:03505010.6GJA5, NKX2-5
26cardiac muscle contractionGO:06004810.5TCAP, TNNI3, TNNC1, SCN4B, NKX2-5, MYL2
27regulation of the force of heart contractionGO:00202610.5MYL3, PLN
28positive regulation of sodium ion transportGO:01076510.5NKX2-5, SCN4B
29regulation of ventricular cardiac muscle cell action potentialGO:08600510.5KCNE2, GJA5
30cardiac muscle cell differentiationGO:05500710.4MYLK2, NKX2-5
31sarcomere organizationGO:04521410.4TCAP, NKX2-5
32ventricular septum morphogenesisGO:06041210.3GJA5, NKX2-5
33synaptic transmissionGO:00726810.0KCNA5, KCNJ2, GNB3, SLC6A2

Molecular functions related to Syncope according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin T bindingGO:03101410.5TNNC1, TNNI3
2structural constituent of muscleGO:00830710.4TCAP, MYL3, MYL2
3inward rectifier potassium channel activityGO:00524210.4KCNJ2, KCNE2
4ion channel bindingGO:04432510.4KCNE2, SCN4B, TCAP
5alpha-actinin bindingGO:05139310.3ADORA2A, KCNA5
6actin monomer bindingGO:00378510.1MYL3, MYL2

Products for genes affiliated with Syncope

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  • Lysates
  • Antibodies

Sources for Syncope

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet