MCID: SYN036
MIFTS: 44

Syncope malady

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Summaries for Syncope

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4CDC, 44NINDS, 65Wikipedia, 33MalaCards
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NINDS:44 Syncope is a medical term used to describe a temporary loss of consciousness due to the sudden decline of blood flow to the brain. Syncope is commonly called fainting or ?passing out.? If an individual is about to faint, he or she will feel dizzy, lightheaded, or nauseous and their field of vision may ?white out? or ?black out.?

MalaCards: Syncope is related to orthostatic intolerance and atrioventricular block. An important gene associated with Syncope is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are Sympathetic Nerve Pathway (Neuroeffector Junction) and Hypertrophic cardiomyopathy (HCM). The compounds pseudoephedrine and desipramine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and heart, and related mouse phenotypes are muscle and cardiovascular system.

CDC:4 On October 25, 2007, updated information about syncope reports to the Vaccine Adverse Event Reporting System (VAERS) from January 1, 2005 through July 31, 2007 was presented to the Advisory Committee on Immunization Practices (ACIP). The committee was also reminded about the current ACIP recommendations to prevent syncope and its related sequelae from occurring after vaccination.

Wikipedia:65 Syncope may refer to one of the following: more...

Aliases & Classifications for Syncope

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44NINDS
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Aliases & Descriptions:

syncope 44


Related Diseases for Syncope

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17GeneCards, 18GeneDecks
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Diseases related to Syncope via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1orthostatic intolerance30.8SLC6A2
2atrioventricular block30.5NKX2-5
3brugada syndrome30.5KCNE2, SCN4B
4long qt syndrome30.4SCN4B, KCNE2
5coronary artery disease30.0SLC6A2, ADRB1
6congenital heart block29.7KCNE2, SCN4B
7glossopharyngeal neuralgia10.6
8fainting10.5
9sick sinus syndrome10.4
10postural orthostatic tachycardia syndrome10.3
11cerebritis10.3
12familial neurocardiogenic syncope10.3
13ventricular extrasystoles with syncopal episodes - perodactyly - robin sequence10.3
14hypertension10.2
15migraine10.2
16pulmonary embolism10.2
17catecholaminergic polymorphic ventricular tachycardia10.2
18carotid body tumor10.2
19left ventricular outflow tract obstruction10.2
20postural hypotension10.2
21wolff-parkinson-white syndrome10.1
22hypertrophic cardiomyopathy10.1
23temporal lobe epilepsy10.1
24arrhythmogenic right ventricular dysplasia10.1
25myocarditis10.1
26cor triatriatum10.1
27mastocytosis10.1
28generalized anxiety disorder10.1SLC6A2
29familial atrial fibrillation10.1KCNE2
30pharyngitis10.1
31constrictive pericarditis10.1
32subclavian steal syndrome10.1
33esophagitis10.1
34hypothyroidism10.1
35pericarditis10.1
36systemic mastocytosis10.1
37exercise induced anaphylaxis10.1
38prinzmetal's variant angina10.1
39ventricular tachycardia, catecholaminergic polymorphic, 110.1
40panic disorder10.0SLC6A2, RGS2
41essential hypertension10.0SLC6A2, ADRB1
42familial hypertrophic cardiomyopathy10.0TCAP, PLN, CALR3
43dilated cardiomyopathy10.0ADRB1, TCAP, PLN
44sudden cardiac death multi-gene panels10.0ADRB1, KCNE2
45rheumatic fever10.0
46jervell-lange nielsen syndrome10.0
47mitral valve prolapse10.0
48meningocele10.0
49quadriplegia10.0
50right bundle branch block10.0

Graphical network of the top 20 diseases related to Syncope:



Diseases related to syncope

Symptoms for Syncope

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Drugs & Therapeutics for Syncope

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Search NIH Clinical Center for Syncope

Genetic Tests for Syncope

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Anatomical Context for Syncope

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33MalaCards
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MalaCards organs/tissues related to Syncope:

33
Testes, Brain, Heart, Tongue, Temporal lobe, Lung, Prostate, Endothelial, B cells, Thyroid, Skin, Whole blood, Bone, Atrioventricular node

Animal Models for Syncope or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Syncope:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.9ADRB1, TCAP, PLN, NKX2-5, RGS2
2MP:00053857.8SLC6A2, RGS2, NKX2-5, PLN, TCAP, ADRB1
3MP:00053767.7SLC6A2, NKX2-5, PLN, TCAP, ADRB1, KCNE2

Publications for Syncope

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52PubMed
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Articles related to Syncope:

(show top 50)    (show all 735)
idTitleAuthorsYear
1
Near-infrared diffuse optical monitoring of cerebral blood flow and oxygenation for the prediction of vasovagal syncope. (24402372)
2014
2
Postexercise syncope: Wingate syncope test and effective countermeasure. (24078670)
2014
3
Malignant cardioinhibitory vasovagal syncope - an uncommon cardiovascular complication of Roux-en-Y gastric bypass surgery: the fainting syndrome! (23063207)
2013
4
Accuracy of the ICD-10 discharge diagnosis for syncope. (23129545)
2013
5
Prognostic value of the OESIL risk score in a cohort of Emergency Department patients with syncope. (24008603)
2013
6
Prevalence of fibromyalgia in vasovagal syncope. (23519175)
2013
7
The San Francisco Syncope Rule performs well in a regional rural emergency department in New Zealand. (23799380)
2013
8
Value of history taking in children and adolescents with cardiac syncope. (22417947)
2013
9
Percutaneous atrial septostomy with modified butterfly stent and intracardiac echocardiographic guidance in a patient with syncope and refractory pulmonary arterial hypertension. (23402682)
2013
10
Re: age-related prognosis of syncope associated with a preexcitation syndrome. (23713681)
2013
11
Postural orthostatic tachycardia syndrome, neurally-mediated syncope, and joint hypermobility: a case report. (23490229)
2013
12
Syncope associated with documented paroxysmal atrioventricular block reproduced by adenosine 5' triphosphate injection. (24128810)
2013
13
Atrial Electromechanical Conduction Delay in Patients with Neurocardiogenic Syncope. (24215448)
2013
14
Vasovagal syncope: new physiologic insights. (23217689)
2013
15
Treatment of neurally mediated reflex syncope. (23217693)
2013
16
Predictors of vasovagal syncope recurrence in children and adolescents and value of head-up tilt table test. (23996804)
2013
17
Pearls & Oy-sters: ictal syncope in a patient with temporal lobe epilepsy. (24325018)
2013
18
Medical therapy and physical maneuvers in the treatment of the vasovagal syncope and orthostatic hypotension. (23472781)
2013
19
Recurrent orthostatic syncope due to left atrial and left ventricular collapse after a continuous-flow left ventricular assist device implantation. (23260713)
2013
20
Acute right ventricular myocarditis presenting with chest pain and syncope. (24096068)
2013
21
Asystole due to head scratching: a newly confirmed situational syncope. (23872689)
2013
22
Recurrent syncope: a slow heart rate? (23864482)
2013
23
Pearls & Oy-sters: ictal syncope in a patient with temporal lobe epilepsy. (24166964)
2013
24
Renal nerve stimulation for the treatment of neurocardiogenic syncope. (23773500)
2013
25
Ivabradine in treatment of sinus tachycardia mediated vasovagal syncope. (24072450)
2013
26
Nutcracker syndrome: symptoms of syncope and hypotension improved following endovascular stenting. (22734085)
2012
27
Letter by Lagro et al regarding article, "Treatment of unexplained syncope: a multicenter, randomized trial of cardiac pacing guided by adenosine 5'-triphosphate testing". (22908021)
2012
28
Syncope in a patient being treated for hepatic and intestinal amoebiasis. (23203174)
2012
29
Sensitive troponin assay predicts outcome in syncope. (22962048)
2012
30
Defining abnormal electrocardiography in adult emergency department syncope patients: the Ottawa Electrocardiographic Criteria. (22813399)
2012
31
A rare cause of syncope: cough. (22582489)
2012
32
Syncope: evaluation and management in the geriatric patient. (23101580)
2012
33
Positive result in the early passive phase of the tilt-table test: a predictor of neurocardiogenic syncope in young men. (22403501)
2012
34
An unusual presentation of pericardial cyst: recurrent syncope in a young patient. (22461053)
2012
35
Syncope. (22032666)
2011
36
Vasovagal syncope as a cause of syncope in long-QT syndrome. (21718921)
2011
37
Mild hyperkalemia and low eGFR a tedious recipe for cardiac disaster in the elderly: an unusual reversible cause of syncope and heart block. (22049311)
2011
38
Neurally mediated syncope associated with small cell lung cancer: a case report and review. (22001467)
2011
39
Syncope in cardiac amyloidosis and chronic ischemic heart disease: A case report. (21747665)
2011
40
Risk of syncope in family members who are genotype-negative for a family-associated long-QT syndrome mutation. (21831960)
2011
41
Tussive syncope in a pug with lung-lobe torsion. (22131584)
2011
42
An 8-year-old girl with headache and syncope. (22148273)
2011
43
Seizure or syncope: the diagnostic value of serum creatine kinase and myoglobin levels. (19190495)
2009
44
Syncope and QT prolongation among patients treated with methadone for heroin dependence in the city of Copenhagen. (17344330)
2007
45
Furosemide-induced recurrent syncope in myxedema. (15939116)
2005
46
Syncope in a patient with relapsing polychondritis. (14644874)
2003
47
Syncope resulting from autonomic insufficiency syndromes associated with orthostatic intolerance. (11233955)
2001
48
Neurocardiogenic syncope and Prinzmetal's angina associated with bronchogenic carcinoma. (9118728)
1997
49
Role of endogenous opioids and catecholamines in vasovagal syncope. (8922923)
1996
50
Syncope caused by carotid body tumor. (9046120)
1996

Variations for Syncope

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Expression for genes affiliated with Syncope

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Syncope

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Pathways for genes affiliated with Syncope

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50PathCards, 51PharmGKB, 30KEGG, 38NCBI BioSystems Database, 5Cell Signaling Technology, 60Thomson Reuters, 53QIAGEN
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Pathways related to Syncope according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6ADRB1, SLC6A2
2
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy38
9.6ADRB1, PLN
39.6PLN, ADRB1
4
Show member pathways
Development Beta adrenergic receptors regulation of ERK60
G protein signaling G Protein alpha s signaling cascades60
G protein signaling G Protein beta gamma signaling cascades60
9.5RGS2, ADRB1
5
Show member pathways
9.3ADRB1, KCNE2
6
Show member pathways
Calcium Regulation in the Cardiac Cell38
9.1RGS2, PLN, ADRB1
78.8SCN4B, ADRB1, PLN
8
Show member pathways
8.3SCN4B, ADRB1, PLN, RGS2
98.1KCNE2, SCN4B, ADRB1, PLN

Compounds for genes affiliated with Syncope

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45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB
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Compounds related to Syncope according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pseudoephedrine45 24 1111.7ADRB1, SLC6A2
2desipramine45 51 1111.7ADRB1, SLC6A2
3catecholamine459.6ADRB1, SLC6A2
4forskolin45 51 1111.1ADRB1, RGS2, SLC6A2
5adenylate458.9RGS2, ADRB1, SLC6A2
6calcium45 51 24 1111.5SLC6A2, RGS2, ADRB1, CALR3, PLN
7sodium45 249.3KCNE2, SCN4B, ADRB1, SLC6A2

GO Terms for genes affiliated with Syncope

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16Gene Ontology
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Biological processes related to Syncope according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1relaxation of cardiac muscleGO:0551199.9RGS2, PLN
2regulation of cardiac muscle cell contractionGO:0860049.8ADRB1, PLN
3cardiac muscle tissue morphogenesisGO:0550089.7NKX2-5, TCAP
4adult heart developmentGO:0075129.7TCAP, NKX2-5
5regulation of calcium ion transportGO:0519249.6ADRB1, PLN
6sarcomere organizationGO:0452149.4TCAP, NKX2-5
7positive regulation of sodium ion transportGO:0107659.4NKX2-5, SCN4B
8agingGO:0075689.3ADRB1, KCNE2
9cardiac muscle cell action potential involved in contractionGO:0860029.3KCNE2, SCN4B
10regulation of ventricular cardiac muscle cell membrane repolarizationGO:0603079.2SCN4B, KCNE2
11brown fat cell differentiationGO:0508739.2RGS2, ADRB1
12regulation of heart rate by cardiac conductionGO:0860919.1SCN4B, KCNE2
13cardiac muscle contractionGO:0600489.0NKX2-5, TCAP, SCN4B

Molecular functions related to Syncope according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-tubulin bindingGO:0484879.7SLC6A2, RGS2
2ion channel bindingGO:0443258.2TCAP, SCN4B, KCNE2

Products for genes affiliated with Syncope

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Sources for Syncope

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet