MCID: SYN036
MIFTS: 35

Syncope malady

Summaries for Syncope

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3CDC, 43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Syncope is a medical term used to describe a temporary loss of consciousness due to the sudden decline of blood flow to the brain. Syncope is commonly called fainting or ?passing out.? If an individual is about to faint, he or she will feel dizzy, lightheaded, or nauseous and their field of vision may ?white out? or ?black out.?

MalaCards: Syncope is related to long qt syndrome and hypertension. An important gene associated with Syncope is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are Adrenoceptors and Cardiomyocyte Differentiation through BMP Receptors. The compounds n-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide and pseudoephedrine have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are respiratory system and muscle.

CDC:3 On October 25, 2007, updated information about syncope reports to the Vaccine Adverse Event Reporting System (VAERS) from January 1, 2005 through July 31, 2007 was presented to the Advisory Committee on Immunization Practices (ACIP). The committee was also reminded about the current ACIP recommendations to prevent syncope and its related sequelae from occurring after vaccination.

Wikipedia:63 Syncope may refer to one of the following: more...

Aliases & Classifications for Syncope

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43NINDS
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Aliases & Descriptions:

syncope 43


Related Diseases for Syncope

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17GeneCards, 18GeneDecks
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Diseases related to Syncope via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1long qt syndrome30.4SCN4B, KCNJ2, KCNE2, KCNA5
2hypertension30.3KCNA5, GNB3, RGS2, ADRB1
3hypertrophic cardiomyopathy30.2TNNI3, MYL2, MYL3
4ischemia29.9ADORA2A, SLC6A2
5myocardial infarction29.9ADRB1, MYL3, TNNI3, GNB3
6ischemic heart disease29.9ADRB1, SLC6A2, TNNI3
7familial atrial fibrillation29.7GATA5, KCNE2
8acute myocardial infarction29.7TNNI3, MYL3, ADRB1
9glossopharyngeal neuralgia10.6
10sick sinus syndrome10.4
11brugada syndrome10.3
12atrioventricular block10.3
13cerebritis10.3
14familial neurocardiogenic syncope10.3
15fainting10.3
16ventricular extrasystoles with syncopal episodes - perodactyly - robin sequence10.2
17catecholaminergic polymorphic ventricular tachycardia10.2
18migraine10.2
19pulmonary embolism10.2
20wolff-parkinson-white syndrome10.1
21temporal lobe epilepsy10.1
22arrhythmogenic right ventricular dysplasia10.1
23myocarditis10.1
24subclavian steal syndrome10.0
25jervell-lange nielsen syndrome10.0
26pharyngitis10.0
27constrictive pericarditis10.0
28esophagitis10.0
29hypothyroidism10.0
30pericarditis10.0
31systemic mastocytosis10.0
32ventricular tachycardia, catecholaminergic polymorphic, 110.0
33congestive heart failure10.0TNNI3
34familial restrictive cardiomyopathy10.0TNNI3
35myopathy10.0TCAP, TNNI3
36dilated cardiomyopathy10.0TNNI3, PLN, TCAP, ADRB1
37familial hypertrophic cardiomyopathy10.0TCAP, MYLK2
38sudden cardiac death multi-gene panels10.0ADRB1, KCNJ2, KCNE2
39orthostatic intolerance10.0SLC6A2
40noonan syndrome10.0ADRB1, TCAP, PLN, MYL2, NKX2-5, TNNI3
41hypertrophy of breast10.0GNB3, MYL2, PLN, RGS2, ADRB1
42essential hypertension10.0GNB3, SLC6A2, ADRB1, ADORA2A
43congenital heart defect10.0GJA5
44anorexia nervosa10.0SLC6A2
45panic disorder10.0RGS2, SLC6A2, ADORA2A
46generalized anxiety disorder10.0SLC6A2
47coronary artery disease10.0
48right bundle branch block10.0
49primary pulmonary hypertension10.0
50mitral valve prolapse10.0

Graphical network of the top 20 diseases related to Syncope:



Diseases related to syncope

Clinical Features for Syncope

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Drugs & Therapeutics for Syncope

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Syncope

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Anatomical Context for Syncope

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32MalaCards
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MalaCards organs/tissues related to Syncope:

32
Brain

Animal Models for Syncope or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Syncope:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.2TNNI3, NKX2-5, MYL2, GJA5, ADORA2A, KCNJ2
2MP:00053699.9ADORA2A, KCNA5, KCNJ2, TNNI3, GATA5, NKX2-5
3MP:00053859.9NKX2-5, GATA5, TNNI3, KCNJ2, KCNA5, MYL2
4MP:00053769.7NKX2-5, GATA5, KCNJ2, KCNE2, KCNA5, MYL2

Publications for Syncope

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Genetic Variations for Syncope

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Expression for genes affiliated with Syncope

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Syncope

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Pathways for genes affiliated with Syncope

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53Reactome, 49PharmGKB, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology, 29KEGG
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Pathways related to Syncope according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.4ADRB1, SLC6A2
210.4MYL2, NKX2-5
3
G-protein signaling G-Protein alpha-i signaling cascades
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10.4ADRB1, RGS2, GNB3
4
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10.4MYL3, MYLK2, GNB3
5
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10.4KCNA5, KCNJ2, GNB3
610.3MYL2, NKX2-5, TNNI3
710.3KCNA5, KCNE2, KCNJ2, GNB3
8
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10.3GNB3, MYLK2, MYL3, PLN
910.3ADRB1, PLN, TNNI3, GNB3
10
Immune response CCR3 signaling in eosinophils
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10.3GNB3, MYL2, MYLK2, MYL3
11
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10.3TNNI3, TNNC1, PLN, ADRB1
12
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10.3KCNE2, KCNJ2, MYLK2, ADRB1
1310.3TNNI3, TNNC1, MYL2, MYL3
1410.3TNNC1, MYLK2, PLN, ADRB1, ADORA2A
15
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10.2TNNI3, TNNC1, MYL2, MYL3, TCAP
16
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10.2TNNI3, TNNC1, MYL2, MYL3, PLN, ADRB1
17
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10.2GNB3, MYL2, MYLK2, GJA5, PLN, RGS2
1810.2ADRB1, KCNA5, KCNE2, KCNJ2, SCN4B, GJA5
19
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10.1GNB3, TNNI3, SCN4B, MYL2, MYL3, PLN

Compounds for genes affiliated with Syncope

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Syncope according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1n-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide44 1111.7TNNC1, TNNI3
2pseudoephedrine44 11 2412.7SLC6A2, ADRB1
3Droxidopa1110.6ADRB1, SLC6A2
4Ephedra1110.6ADRB1, SLC6A2
5sibutramine44 1111.6SLC6A2, GNB3
6amine4410.6KCNJ2, SLC6A2, ADORA2A
7sodium44 2411.5KCNE2, GNB3, SCN4B, GJA5, SLC6A2, ADRB1
8forskolin44 49 1112.5ADRB1, RGS2
9nitric oxide44 11 2412.5GNB3, NKX2-5, MYLK2, GJA5, ADRB1, ADORA2A
10norepinephrine44 11 2412.5GNB3, SLC6A2, ADRB1, ADORA2A
11quinpirole44 2811.5ADORA2A, RGS2
12potassium44 11 2412.4KCNA5, KCNE2, KCNJ2, GNB3, TNNI3, MYL2
13(r)-(+)-blebbistatin5910.4MYL3, MYL2
14(+-)-blebbistatin5910.4MYL2, MYL3
15bts5910.3MYL2, MYL3
16calcium44 49 11 2413.2ADORA2A, KCNA5, KCNJ2, CALR3, TNNI3, TNNC1
17(s)-(-)-blebbistatin5910.1MYL2, MYL3

GO Terms for genes affiliated with Syncope

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16Gene Ontology
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Cellular components related to Syncope according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1I bandGO:03167410.4TCAP, MYL3
2sarcomereGO:03001710.4MYL3, MYLK2, MYL2, TNNI3
3intercalated discGO:01470410.3GJA5, SCN4B, KCNA5
4troponin complexGO:00586110.3TNNI3, TNNC1
5voltage-gated potassium channel complexGO:00807610.0KCNJ2, KCNE2, KCNA5

Biological processes related to Syncope according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1cardiac conduction system developmentGO:00316110.8GJA5, NKX2-5
2cardiac muscle tissue morphogenesisGO:05500810.7NKX2-5, MYLK2, TCAP
3membrane repolarization involved in regulation of action potentialGO:08601110.7KCNJ2, KCNE2
4relaxation of cardiac muscleGO:05511910.7KCNJ2, PLN, RGS2
5negative regulation of ATPase activityGO:03278010.7TNNI3, PLN
6membrane depolarization involved in regulation of cardiac muscle cell action potentialGO:08601210.7SCN4B, KCNJ2
7regulation of cardiac muscle cell action potential involved in contractionGO:08600210.7SCN4B, KCNJ2, KCNE2
8potassium ion importGO:01010710.7KCNE2, KCNJ2
9regulation of ventricular cardiac muscle cell membrane repolarizationGO:06030710.7GJA5, SCN4B, KCNE2
10regulation of inhibitory postsynaptic membrane potentialGO:06008010.7ADORA2A, ADRB1
11regulation of calcium ion transportGO:05192410.7PLN, ADRB1, ADORA2A
12potassium ion exportGO:07143510.7KCNA5, KCNE2
13regulation of atrial cardiac muscle cell action potentialGO:08601410.7KCNA5, GJA5
14regulation of cardiac muscle cell contractionGO:08600410.7PLN, ADRB1
15atrial septum morphogenesisGO:06041310.7NKX2-5, GJA5
16ventricular cardiac muscle tissue morphogenesisGO:05501010.7MYL3, MYL2, TNNC1, TNNI3
17regulation of membrane repolarizationGO:06030610.7KCNE2, KCNJ2
18regulation of striated muscle contractionGO:00694210.7MYL2, MYL3
19regulation of heart rate by cardiac conductionGO:08609110.6KCNA5, KCNE2, KCNJ2, SCN4B, GJA5
20muscle filament slidingGO:03004910.6TNNI3, TNNC1, MYL2, MYL3, TCAP
21heart contractionGO:06004710.6TNNI3, MYL2
22cardiac myofibril assemblyGO:05500310.6TCAP, MYL2
23regulation of cardiac muscle contractionGO:05511710.6NKX2-5, GJA5
24adult heart developmentGO:00751210.6TCAP, NKX2-5
25embryonic heart tube developmentGO:03505010.6GJA5, NKX2-5
26cardiac muscle contractionGO:06004810.5TCAP, TNNI3, TNNC1, SCN4B, NKX2-5, MYL2
27regulation of the force of heart contractionGO:00202610.5MYL3, PLN
28positive regulation of sodium ion transportGO:01076510.5NKX2-5, SCN4B
29regulation of ventricular cardiac muscle cell action potentialGO:08600510.5KCNE2, GJA5
30cardiac muscle cell differentiationGO:05500710.4MYLK2, NKX2-5
31sarcomere organizationGO:04521410.4TCAP, NKX2-5
32ventricular septum morphogenesisGO:06041210.3GJA5, NKX2-5
33synaptic transmissionGO:00726810.0KCNA5, KCNJ2, GNB3, SLC6A2

Molecular functions related to Syncope according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin T bindingGO:03101410.5TNNC1, TNNI3
2structural constituent of muscleGO:00830710.4TCAP, MYL3, MYL2
3inward rectifier potassium channel activityGO:00524210.4KCNJ2, KCNE2
4ion channel bindingGO:04432510.4KCNE2, SCN4B, TCAP
5alpha-actinin bindingGO:05139310.3ADORA2A, KCNA5
6actin monomer bindingGO:00378510.1MYL3, MYL2

Products for genes affiliated with Syncope

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Sources for Syncope

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet