MCID: SYN036
MIFTS: 44

Syncope malady

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Summaries for Syncope

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NINDS:43 Syncope is a medical term used to describe a temporary loss of consciousness due to the sudden decline of blood flow to the brain. Syncope is commonly called fainting or ?passing out.? If an individual is about to faint, he or she will feel dizzy, lightheaded, or nauseous and their field of vision may ?white out? or ?black out.?

MalaCards based summary: Syncope is related to orthostatic intolerance and atrioventricular block. An important gene associated with Syncope is SLC6A2 (solute carrier family 6 (neurotransmitter transporter), member 2), and among its related pathways are Sympathetic Nerve Pathway (Neuroeffector Junction) and Hypertrophic cardiomyopathy (HCM). The compounds pseudoephedrine and desipramine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and heart, and related mouse phenotypes are muscle and cardiovascular system.

CDC:3 On October 25, 2007, updated information about syncope reports to the Vaccine Adverse Event Reporting System (VAERS) from January 1, 2005 through July 31, 2007 was presented to the Advisory Committee on Immunization Practices (ACIP). The committee was also reminded about the current ACIP recommendations to prevent syncope and its related sequelae from occurring after vaccination.

Wikipedia:65 Syncope may refer to one of the following: more...

Aliases & Classifications for Syncope

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Syncope, Aliases & Descriptions:

Name: Syncope 43


Related Diseases for Syncope

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Diseases related to Syncope via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 198)
idRelated DiseaseScoreTop Affiliating Genes
1orthostatic intolerance31.3SLC6A2
2atrioventricular block31.0NKX2-5
3brugada syndrome30.4KCNE2, SCN4B
4familial atrial fibrillation30.3KCNE2
5long qt syndrome30.2SCN4B, KCNE2
6coronary artery anomaly29.7SLC6A2, ADRB1
7congenital heart block29.6KCNE2, SCN4B
8glossopharyngeal neuralgia10.6
9fainting10.5
10sick sinus syndrome10.5
11generalized anxiety disorder10.4SLC6A2
12postural orthostatic tachycardia syndrome10.4
13cerebritis10.3
14catecholaminergic polymorphic ventricular tachycardia10.3
15familial neurocardiogenic syncope10.3
16ventricular extrasystoles with syncopal episodes - perodactyly - robin sequence10.3
17hypertension10.2
18pulmonary embolism10.2
19migraine10.2
20carotid body tumor10.2
21left ventricular outflow tract obstruction10.2
22postural hypotension10.2
23ventricular tachycardia, catecholaminergic polymorphic, 110.2
24jervell-lange nielsen syndrome10.1
25wolff-parkinson-white syndrome10.1
26hypertrophic cardiomyopathy10.1
27myocarditis10.1
28cor triatriatum10.1
29mastocytosis10.1
30essential hypertension10.1SLC6A2, ADRB1
31systemic mastocytosis10.1
32temporal lobe epilepsy10.1
33pharyngitis10.1
34subclavian steal syndrome10.1
35constrictive pericarditis10.1
36esophagitis10.1
37hypothyroidism10.1
38pericarditis10.1
39exercise induced anaphylaxis10.1
40prinzmetal's variant angina10.1
41autonomic dysfunction10.1
42panic disorder10.1SLC6A2, RGS2
43familial hypertrophic cardiomyopathy10.0TCAP, PLN, CALR3
44hepatitis10.0
45ischemic heart disease10.0
46myocardial infarction10.0
47pulmonary hypertension10.0
48primary pulmonary hypertension10.0
49rheumatic fever10.0
50mitral valve prolapse10.0

Graphical network of the top 20 diseases related to Syncope:



Diseases related to syncope

Symptoms for Syncope

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Drugs & Therapeutics for Syncope

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Drug clinical trials:

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Search NIH Clinical Center for Syncope

Genetic Tests for Syncope

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Anatomical Context for Syncope

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MalaCards organs/tissues related to Syncope:

32
Testes, Brain, Heart, Tongue, Lung, Temporal lobe, Thyroid, Bone, Whole blood, Skin, Prostate, B cells, Endothelial, Atrioventricular node

Animal Models for Syncope or affiliated genes

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MGI Mouse Phenotypes related to Syncope:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.9TCAP, PLN, NKX2-5, RGS2, ADRB1
2MP:00053857.8SLC6A2, ADRB1, TCAP, PLN, NKX2-5, RGS2
3MP:00053767.7ADRB1, KCNE2, TCAP, NKX2-5, SLC6A2, PLN

Publications for Syncope

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Articles related to Syncope:

(show top 50)    (show all 766)
idTitleAuthorsYear
1
Heart rate variability analysis during head-up tilt test predicts nitroglycerine-induced syncope. (25332802)
2014
2
Far-field ventricular sensing defects and syncope in a patient with right subclavian VDD pace-maker. (25304074)
2014
3
'Um, I think she just died'. Carefully evaluate & monitor all patients with syncope. (25322513)
2014
4
Cardiac Autonomic Dysfunction in Patients with Head-up Tilt Test-Induced Vasovagal Syncope. (25139789)
2014
5
Near-infrared diffuse optical monitoring of cerebral blood flow and oxygenation for the prediction of vasovagal syncope. (24402372)
2014
6
Postexercise syncope: Wingate syncope test and effective countermeasure. (24078670)
2014
7
Malignant cardioinhibitory vasovagal syncope - an uncommon cardiovascular complication of Roux-en-Y gastric bypass surgery: the fainting syndrome! (23063207)
2013
8
Accuracy of the ICD-10 discharge diagnosis for syncope. (23129545)
2013
9
Prognostic value of the OESIL risk score in a cohort of Emergency Department patients with syncope. (24008603)
2013
10
Prevalence of fibromyalgia in vasovagal syncope. (23519175)
2013
11
The San Francisco Syncope Rule performs well in a regional rural emergency department in New Zealand. (23799380)
2013
12
Value of history taking in children and adolescents with cardiac syncope. (22417947)
2013
13
Percutaneous atrial septostomy with modified butterfly stent and intracardiac echocardiographic guidance in a patient with syncope and refractory pulmonary arterial hypertension. (23402682)
2013
14
Re: age-related prognosis of syncope associated with a preexcitation syndrome. (23713681)
2013
15
Postural orthostatic tachycardia syndrome, neurally-mediated syncope, and joint hypermobility: a case report. (23490229)
2013
16
Syncope associated with documented paroxysmal atrioventricular block reproduced by adenosine 5' triphosphate injection. (24128810)
2013
17
Atrial Electromechanical Conduction Delay in Patients with Neurocardiogenic Syncope. (24215448)
2013
18
Vasovagal syncope: new physiologic insights. (23217689)
2013
19
Treatment of neurally mediated reflex syncope. (23217693)
2013
20
Predictors of vasovagal syncope recurrence in children and adolescents and value of head-up tilt table test. (23996804)
2013
21
Medical therapy and physical maneuvers in the treatment of the vasovagal syncope and orthostatic hypotension. (23472781)
2013
22
Recurrent orthostatic syncope due to left atrial and left ventricular collapse after a continuous-flow left ventricular assist device implantation. (23260713)
2013
23
Acute right ventricular myocarditis presenting with chest pain and syncope. (24096068)
2013
24
Asystole due to head scratching: a newly confirmed situational syncope. (23872689)
2013
25
Recurrent syncope: a slow heart rate? (23864482)
2013
26
Pearls & Oy-sters: ictal syncope in a patient with temporal lobe epilepsy. (24166964)
2013
27
Renal nerve stimulation for the treatment of neurocardiogenic syncope. (23773500)
2013
28
Nutcracker syndrome: symptoms of syncope and hypotension improved following endovascular stenting. (22734085)
2012
29
Letter by Lagro et al regarding article, "Treatment of unexplained syncope: a multicenter, randomized trial of cardiac pacing guided by adenosine 5'-triphosphate testing". (22908021)
2012
30
Syncope in a patient being treated for hepatic and intestinal amoebiasis. (23203174)
2012
31
Sensitive troponin assay predicts outcome in syncope. (22962048)
2012
32
Defining abnormal electrocardiography in adult emergency department syncope patients: the Ottawa Electrocardiographic Criteria. (22813399)
2012
33
A rare cause of syncope: cough. (22582489)
2012
34
Syncope: evaluation and management in the geriatric patient. (23101580)
2012
35
Positive result in the early passive phase of the tilt-table test: a predictor of neurocardiogenic syncope in young men. (22403501)
2012
36
Syncope. (22032666)
2011
37
Vasovagal syncope as a cause of syncope in long-QT syndrome. (21718921)
2011
38
Mild hyperkalemia and low eGFR a tedious recipe for cardiac disaster in the elderly: an unusual reversible cause of syncope and heart block. (22049311)
2011
39
Neurally mediated syncope associated with small cell lung cancer: a case report and review. (22001467)
2011
40
Syncope in cardiac amyloidosis and chronic ischemic heart disease: A case report. (21747665)
2011
41
Risk of syncope in family members who are genotype-negative for a family-associated long-QT syndrome mutation. (21831960)
2011
42
Tussive syncope in a pug with lung-lobe torsion. (22131584)
2011
43
Seizure or syncope: the diagnostic value of serum creatine kinase and myoglobin levels. (19190495)
2009
44
Syncope and QT prolongation among patients treated with methadone for heroin dependence in the city of Copenhagen. (17344330)
2007
45
Furosemide-induced recurrent syncope in myxedema. (15939116)
2005
46
Catecholaminergic polymorphic ventricular tachycardia, recurrent syncope, and implantable loop recorder. (15175074)
2004
47
Neurocardiogenic syncope and Prinzmetal's angina associated with bronchogenic carcinoma. (9118728)
1997
48
Role of endogenous opioids and catecholamines in vasovagal syncope. (8922923)
1996
49
Syncope caused by carotid body tumor. (9046120)
1996
50
Immunoblastic lymphoma presenting with syncope due to sinoatrial node disease. (2371193)
1990

Variations for Syncope

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Expression for genes affiliated with Syncope

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Expression patterns in normal tissues for genes affiliated with Syncope

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Pathways for genes affiliated with Syncope

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Pathways related to Syncope according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6ADRB1, SLC6A2
2
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
9.6ADRB1, PLN
39.6PLN, ADRB1
4
Show member pathways
Development Beta adrenergic receptors regulation of ERK60
G protein signaling G Protein alpha s signaling cascades60
G protein signaling G Protein beta gamma signaling cascades60
9.5RGS2, ADRB1
5
Show member pathways
9.3ADRB1, KCNE2
6
Show member pathways
Calcium Regulation in the Cardiac Cell37
9.1RGS2, PLN, ADRB1
78.8SCN4B, ADRB1, PLN
8
Show member pathways
8.3SCN4B, ADRB1, PLN, RGS2
98.1KCNE2, SCN4B, ADRB1, PLN

Compounds for genes affiliated with Syncope

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 50PharmGKB
See all sources

Compounds related to Syncope according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pseudoephedrine44 24 1111.7ADRB1, SLC6A2
2desipramine44 50 1111.7ADRB1, SLC6A2
3catecholamine449.6ADRB1, SLC6A2
4forskolin44 50 1111.1ADRB1, RGS2, SLC6A2
5adenylate448.9RGS2, ADRB1, SLC6A2
6calcium44 50 24 1111.5SLC6A2, RGS2, ADRB1, CALR3, PLN
7sodium44 249.3KCNE2, SCN4B, ADRB1, SLC6A2

GO Terms for genes affiliated with Syncope

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Biological processes related to Syncope according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1relaxation of cardiac muscleGO:0551199.9RGS2, PLN
2regulation of cardiac muscle cell contractionGO:0860049.8ADRB1, PLN
3cardiac muscle tissue morphogenesisGO:0550089.7NKX2-5, TCAP
4adult heart developmentGO:0075129.7TCAP, NKX2-5
5regulation of calcium ion transportGO:0519249.6ADRB1, PLN
6sarcomere organizationGO:0452149.4TCAP, NKX2-5
7positive regulation of sodium ion transportGO:0107659.4NKX2-5, SCN4B
8agingGO:0075689.3ADRB1, KCNE2
9cardiac muscle cell action potential involved in contractionGO:0860029.3KCNE2, SCN4B
10regulation of ventricular cardiac muscle cell membrane repolarizationGO:0603079.2SCN4B, KCNE2
11brown fat cell differentiationGO:0508739.2RGS2, ADRB1
12regulation of heart rate by cardiac conductionGO:0860919.1SCN4B, KCNE2
13cardiac muscle contractionGO:0600489.0NKX2-5, TCAP, SCN4B

Molecular functions related to Syncope according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-tubulin bindingGO:0484879.7SLC6A2, RGS2
2ion channel bindingGO:0443258.2TCAP, SCN4B, KCNE2

Products for genes affiliated with Syncope

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Sources for Syncope

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet