MCID: SYN001
MIFTS: 52

Syndactyly malady

Summaries for Syndactyly

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Syndactyly (from Greek συν- meaning \"together\" and δακτυλος meaning \"finger\") is a... more...

MalaCards: Syndactyly, also known as webbing of digits, is related to polydactyly and brachydactyly-syndactyly syndrome. An important gene associated with Syndactyly is GJA1 (gap junction protein, alpha 1, 43kDa), and among its related pathways is Hedgehog Signaling Pathway. The compound ay 9944 dihydrochloride have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and t cells, and related mouse phenotypes are renal/urinary system and no phenotypic analysis.

Disease Ontology:8 A synostosis that results in the fusion of two or more digits.

Aliases & Classifications for Syndactyly

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 57SNOMED-CT, 27ICD9CM, 61UMLS, 40NCIt, 35MeSH
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Aliases & Descriptions:

syndactyly 8 10 45
webbing of digits 8
polysyndactyly 8
syndactyly nos 8
symphalangism 8
symphalangy 8


External Ids:

Disease Ontology8 DOID:11193
ICD9CM27 755.1
NCIt40 C87125
MeSH35 D013576

Related Diseases for Syndactyly

Sources:
17GeneCards, 18GeneDecks
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Diseases in the syndactyly type 3 family:

syndactyly syndactyly type 9
syndactyly type 1 with cataracts and mental retardation syndactyly type 4
syndactyly type 1 syndactyly type 2
syndactyly type 5 syndactyly type 6

Diseases related to Syndactyly via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 425)
idRelated DiseaseScoreTop Affiliating Genes
1polydactyly30.6SHH, GLI3, HOXD13, HOXD11, HOXD12, DHCR7
2brachydactyly-syndactyly syndrome30.4LPCAT3, HOXD13
3brachydactyly30.3FAM58A, HOXD13
4pallister-hall syndrome29.9SHH, GLI3
5smith-lemli-opitz syndrome29.9DHCR7, SHH
6vacterl association29.6SHH, HOXD13
7symphalangism distal10.5
8syndactyly cenani lenz type10.4
9cryptophthalmos10.4
10thai symphalangism syndrome10.3
11syndactyly type 310.3
12mental retardation10.3
13n syndrome10.3
14ectodermal dysplasia10.3
15oculodentodigital dysplasia10.3
16cleft palate10.3
17syndactyly type 910.3
18acrocephalosyndactylia10.2
19fraser syndrome10.2
20syndactyly type 110.2
21syndactyly type 510.2
22microcephaly10.2
23poland syndrome10.2
24blepharophimosis with ptosis, syndactyly, and short stature10.2
25ectodermal dysplasia mental retardation syndactyly10.2
26syndactyly type 410.2
27timothy syndrome10.2
28micro syndrome10.2
29craniosynostosis philadelphia type10.2
30syndactyly type 210.2
31keloid formation10.2
32multiple synostoses syndrome 110.2
33symphalangism, distal, with microdontia, dental pulp stones, and narrowed zygomatic arch10.2
34symphalangism brachydactyly craniosynostosis10.2
35tracheoesophageal fistula symphalangism10.2
36multiple synostosis syndrome 110.2
37corpus callosum agenesis10.1
38kleiner holmes syndrome10.1
39short ribs craniosynostosis polysyndactyly10.1
40zlotogora syndrome10.1
41filippi syndrome10.1
42syndactyly-polydactyly-earlobe syndrome10.1
43star syndrome10.1
44ectodermal dysplasia - cutaneous syndactyly syndrome10.1
45coronal synostosis, syndactyly and jejunal atresia10.1
46tricho odonto onychodysplasia syndactyly dominant type10.1
47triphalangeal thumb10.1
48synpolydactyly, type ii10.1
49short stature10.1
50premature ovarian failure10.1

Graphical network of the top 20 diseases related to Syndactyly:



Diseases related to syndactyly

Clinical Features for Syndactyly

Drugs & Therapeutics for Syndactyly

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Syndactyly

Drug clinical trials:

Search ClinicalTrials for Syndactyly

Search NIH Clinical Center for Syndactyly

Search CenterWatch for Syndactyly

Genetic Tests for Syndactyly

Anatomical Context for Syndactyly

Sources:
33MalaCards
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MalaCards organs/tissues related to Syndactyly:

33
Skin, Kidney, T cells, B cells, Temporal lobe

Animal Models for Syndactyly or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Syndactyly

Sources:
51PubMed
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Articles related to Syndactyly:

(show top 50)    (show all 404)
idTitleAuthorsYear
1
Syndactyly repair. (23882304)
2013
2
A rare case of simple syndactyly in a puppy. (24345200)
2013
3
Genetic heterogeneity in type III familial cutaneous syndactyly and linkage to chromosome 7q36. (23686920)
2013
4
Oculodentodigital Syndrome with Syndactyly Type III in a Pakistani consanguineous family. (22826718)
2012
5
Syndactyly correction: an aesthetic reconstruction. (20237190)
2010
6
Digital syndactyly release. (20216050)
2010
7
Microcephaly, unusual nose, cutaneous syndactyly, and mental retardation. (20531167)
2010
8
Autosomal dominant syndrome of camptodactyly, clinodactyly, syndactyly, and bifid toes. (20683984)
2010
9
A and B preaxial polydactyly with syndactyly of feet and hands in the same person--a case report. (20053619)
2009
10
Occurrence of central polydactyly, syndactyly, and cleft hand in a single family: report of five hands in three cases. (19762166)
2009
11
Central ray deficiency with extensive syndactyly: a dilemma for classification. (19400540)
2009
12
V-M plasty and double Z-plasty: two versatile flaps for treatment of postburn syndactyly. (19730039)
2009
13
Comment on Shevtsov and Danilkin: Application of external fixation for management of hand syndactyly. (18629496)
2009
14
Cavi-care dressings following syndactyly correction. (18819856)
2009
15
Complex toe syndactyly with characteristic facial phenotype: a new syndrome? (18512233)
2008
16
Cryptophthalmos--syndactyly syndrome. (17240806)
2006
17
Expression of familial middle-ring-little finger syndactyly as either simple syndactyly or synpolydactyly. (16139401)
2006
18
Island flap reconstruction of the web space in congenital incomplete syndactyly. (15234504)
2004
19
Dorsal pentagonal island flap: a technique of web reconstruction for syndactyly that facilitates direct closure. (15810115)
2004
20
Asphyxiating thoracic dystrophy and syndactyly of the toes in a newborn: coincidence or a new association? (12725597)
2003
21
Sandhoff disease in an extreme preterm baby with bilateral syndactyly. (12754550)
2003
22
A case of a rare association of spastic paraplegia and type III syndactyly. (11784386)
2002
23
The open finger technique for release of syndactyly. (11560439)
2001
24
Mutation of the gene encoding fibrillin-2 results in syndactyly in mice. (11285249)
2001
25
Correction of syndactyly: advantages with a non-grafting technique and the use of absorbable skin sutures. (10614753)
1999
26
Syndactyly in Apert syndrome. Utility of a prognostic classification. (10941391)
1999
27
Distal aphalangia, syndactyly, and extra metatarsal, associated with short stature, microcephaly, and borderline intelligence: a new autosomal dominant disorder. (7717420)
1995
28
A large Turkish kindred with syndactyly type II (synpolydactyly). 2. Homozygous phenotype? (7666394)
1995
29
A new operation for syndactyly and polysyndactyly of the foot without skin grafts. (7633768)
1995
30
Ectodermal dysplasia with corkscrew hairs: observation of probable autosomal dominant tricho-odonto-onychodysplasia with syndactyly. (8141890)
1994
31
Split hand/split foot, syndactyly, urinary tract obstruction, radial, diaphragmatic, and neural tube defects: Czeizel-Losonci syndrome? (8074153)
1994
32
Type III syndactyly and oculodentodigital dysplasia: a clinical spectrum. (8110413)
1993
33
Syndactyly type 1 with cataracts and mental retardation. (8287189)
1993
34
The pulp plasty: a composite graft for complete syndactyly fingertip separations. (1311342)
1992
35
Syndactyly: can web creep be avoided? (2164075)
1990
36
A pedigree of cervical stenosis, brachydactyly, syndactyly, and hyperopia. (2551554)
1989
37
Full thickness grafts taken from the plantar instep for syndactyly release. (2545805)
1989
38
Ectrodactyly and syndactyly in a common marmoset (Callithrix jacchus). (3005763)
1986
39
Type II syndactyly or synpolydactyly. (3014149)
1986
40
Apparent bifurcatio of distal humerous with oligoectro-syndactyly. (6305194)
1983
41
Syndactyly and split hand. Supplement. (213354)
1978
42
Burn syndactyly. (208092)
1978
43
Craniosynostosis. II. Coronal synostosis: its familial characteristics and associated clinical findings in 109 patients lacking bilateral polysyndactyly or syndactyly. (882919)
1977
44
Syndactyly and split hand. (181296)
1976
45
Syndactyly of upper limb. Morphogenesis, classification, and management. (174860)
1976
46
Syndactyly in an Aberdeen Angus calf. (4308604)
1969
47
Hereditary brachial and cranial neuritis genetically linked with ocular hypotelorism and syndactyly. (4297726)
1968
48
Asymmetric manifestations of an apparently new syndrome: depressed and pitted skin, facial tumors, syndactyly, and other congenital defects. (4386914)
1968
49
Syndactyly. A clinical report on repair. (5865461)
1965
50
Repair of congenital finger syndactyly. (13487146)
1957

Genetic Variations for Syndactyly

Expression for genes affiliated with Syndactyly

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Syndactyly

Search GEO for disease gene expression data for Syndactyly.

Pathways for genes affiliated with Syndactyly

Sources:
38NCBI BioSystems Database, 60Tocris Bioscience
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Pathways related to Syndactyly according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4GLI3, SHH

Compounds for genes affiliated with Syndactyly

Sources:
60Tocris Bioscience
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Compounds related to Syndactyly according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ay 9944 dihydrochloride6010.4DHCR7, SHH

GO Terms for genes affiliated with Syndactyly

Sources:
16Gene Ontology
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Biological processes related to Syndactyly according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of alpha-beta T cell differentiationGO:04663910.8SHH, GLI3
2hindgut morphogenesisGO:00744210.7GLI3, SHH
3artery developmentGO:06084010.7SHH, GLI3
4metanephros developmentGO:00165610.7HOXD11, GLI3, SHH
5embryonic limb morphogenesisGO:03032610.7FBXW4, SHH, HOXD10
6dorsal/ventral pattern formationGO:00995310.7LRP4, HOXD11, SHH
7positive regulation of alpha-beta T cell differentiationGO:04663810.7GLI3, SHH
8embryonic skeletal system morphogenesisGO:04870410.7HOXD9, HOXD10, GLI3
9embryonic forelimb morphogenesisGO:03511510.7SHH, HOXD11, HOXD9
10hindlimb morphogenesisGO:03513710.7HOXD9, HOXD10
11odontogenesis of dentin-containing toothGO:04247510.7LRP4, GLI3, SHH
12branching involved in ureteric bud morphogenesisGO:00165810.7SHH, GLI3, HOXD11
13peripheral nervous system neuron developmentGO:04893510.7HOXD9, HOXD10
14lung developmentGO:03032410.7SHH, GLI3, DHCR7
15negative thymic T cell selectionGO:04506010.7GLI3, SHH
16limb bud formationGO:06017410.7GJA1, SHH
17proximal/distal pattern formationGO:00995410.6GLI3, HOXD10, HOXD11, HOXD9, LRP4
18negative regulation of canonical Wnt receptor signaling pathwayGO:09009010.6SHH, GLI3, LRP4
19positive regulation of protein import into nucleusGO:04230710.6SHH, GLI3
20anterior/posterior pattern specificationGO:00995210.6SHH, GLI3, HOXD13, HOXD10, HOXD11, HOXD9
21regulation of cell proliferationGO:04212710.6DHCR7, HOXD13, SHH
22positive regulation of chondrocyte differentiationGO:03233210.6GLI3, HOXD11
23phosphatidylserine acyl-chain remodelingGO:03615010.6LPCAT3, MBOAT1
24positive regulation of neuroblast proliferationGO:00205210.5GLI3, SHH
25embryonic digit morphogenesisGO:04273310.5LMBR1, FBXW4, SHH, GLI3, HOXD13, HOXD11
26male genitalia developmentGO:03053910.5HOXD13, SHH
27T cell differentiation in thymusGO:03307710.4GLI3, SHH
28phosphatidylethanolamine acyl-chain remodelingGO:03615210.4LPCAT3, MBOAT1
29positive regulation of transcription from RNA polymerase II promoterGO:04594410.3SHH, GLI3, HOXD13, HOXD10, HOXD9
30heart developmentGO:00750710.3SHH, GLI3, GJA1
31developmental growthGO:04858910.1HOXD11, GLI3

Molecular functions related to Syndactyly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:00370010.2HOXD13, HOXD10, HOXD11, HOXD9, HOXD12, GLI3
2sequence-specific DNA bindingGO:0435659.9HOXD12, HOXD9, HOXD11, HOXD10, HOXD13, GLI3

Products for genes affiliated with Syndactyly

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  • Proteins
  • Lysates
  • Antibodies

Sources for Syndactyly

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet