MCID: SYN001
MIFTS: 43

Syndactyly malady

Genetic diseases, Rare diseases, Bone diseases, Fetal diseases categories

Summaries for Syndactyly

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Wikipedia:63 Syndactyly (from Greek ???- meaning \"together\" and ???????? meaning \"finger\") is a condition wherein... more...

MalaCards based summary: Syndactyly, also known as chromosome 2q35 duplication syndrome, is related to polydactyly and brachydactyly. An important gene associated with Syndactyly is GJA1 (gap junction protein, alpha 1, 43kDa). Affiliated tissues include skin, eye and testes, and related mouse phenotypes are embryogenesis and skeleton.

Disease Ontology:9 A synostosis that results in the fusion of two or more digits.

Aliases & Classifications for Syndactyly

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt, 27ICD9CM, 25ICD10
See all sources

Syndactyly, Aliases & Descriptions:

Name: Syndactyly 9 11 43
Chromosome 2q35 Duplication Syndrome 9
Webbing of Digits 9
 
Symphalangism 9
Symphalangy 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Fetal diseases
Anatomical: Bone diseases


External Ids:

Disease Ontology9 DOID:11193
MeSH33 D013576
NCIt38 C87125
ICD9CM27 755.1
ICD1025 Q70

Related Diseases for Syndactyly

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Diseases in the Syndactyly family:

Syndactyly, Type V Syndactyly, Type Iii
Syndactyly, Type Iv Syndactyly Type 6

Diseases related to Syndactyly via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 493)
idRelated DiseaseScoreTop Affiliating Genes
1polydactyly30.3HOXD13, LMBR1, DHCR7
2brachydactyly30.2HOXD13, FAM58A
3atrioventricular septal defect30.0DHCR7
4syndactyly, type v10.5
5synpolydactyly10.5
6craniosynostosis, philadelphia type10.4
7syndactyly, type iii10.4
8syndactyly, type iv10.4
9syndactyly, mesoaxial synostotic, with phalangeal reduction10.4
10cenani-lenz syndactyly syndrome10.4
11cryptophthalmos10.4
12oculodentodigital dysplasia10.4
13ectodermal dysplasia10.4
14mental retardation10.4
15apert syndrome10.3
16thai symphalangism syndrome10.3
17filippi syndrome10.3
18brachydactyly-syndactyly syndrome10.3
19timothy syndrome10.3
20cleft lip10.3
21blepharophimosis with ptosis, syndactyly, and short stature10.3
22star syndrome10.3
23poland syndrome10.3
24ectodermal dysplasia mental retardation syndactyly10.3
25tarsal-carpal coalition syndrome10.2
26symphalangism, proximal, 1b10.2
27multiple synostoses syndrome10.2
28sillence syndrome10.2
29symphalangism, distal, with microdontia, dental pulp stones, and narrowed zygomatic arch10.2
30tracheoesophageal fistula symphalangism10.2
31fraser syndrome10.2
32greig cephalopolysyndactyly syndrome10.2
33keloids10.2
34microcephaly10.2
35syndactyly-polydactyly-earlobe syndrome10.2
36ectodermal dysplasia - syndactyly syndrome10.2
37polysyndactyly10.2
38ectodermal dysplasia-syndactyly syndrome 110.2
39synpolydactyly, type ii10.2
40megalencephaly-capillary malformation-polymicrogyria syndrome, somatic10.2
41sclerosteosis10.2
42keloid formation10.2
43brachydactyly, type c10.2
44symphalangism brachydactyly craniosynostosis10.2
45symphalangism familial proximal10.2
46symphalangism short stature accessory testis10.2
47pfeiffer syndrome10.2
48brachydactyly, type b110.2
49smith-lemli-opitz syndrome10.2
50microphthalmia with limb anomalies10.2

Graphical network of the top 20 diseases related to Syndactyly:



Diseases related to syndactyly

Symptoms for Syndactyly

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Drugs & Therapeutics for Syndactyly

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Drug clinical trials:

Search ClinicalTrials for Syndactyly

Search NIH Clinical Center for Syndactyly

Genetic Tests for Syndactyly

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Anatomical Context for Syndactyly

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MalaCards organs/tissues related to Syndactyly:

31
Skin, Eye, Testes, Kidney, Bone

Animal Models for Syndactyly or affiliated genes

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MGI Mouse Phenotypes related to Syndactyly:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.2GJA1, FBXW4, LRP4, HOXD13
2MP:00053907.6GJA1, HOXD13, LMBR1, FBXW4, LRP4
3MP:00053787.4HOXD13, LRP4, LMBR1, DHCR7, GJA1
4MP:00053717.3GJA1, DHCR7, LMBR1, FBXW4, LRP4, HOXD13
5MP:00107687.1LMBR1, GJA1, HOXD13, LRP4, DHCR7, FBXW4

Publications for Syndactyly

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Articles related to Syndactyly:

(show top 50)    (show all 423)
idTitleAuthorsYear
1
Preoperative electrocardiograms for nonsyndromic children with hand syndactyly. (25542431)
2015
2
Syndactyly correction using a venous flap with the plantar cutaneous venous arch. (24841825)
2014
3
Formation of normal interdigital web spaces in the hand revisited: implications for the pathogenesis of syndactyly in humans and experimental animals. (23719174)
2013
4
Bilateral macrodystrophia lipomatosa with syndactyly: a case report and literature review. (24164136)
2013
5
Long-term aesthetic outcome of fingertip reconstruction in complete syndactyly release. (23027834)
2013
6
Treatment of congenital syndactyly of the fingers. (23970273)
2013
7
The use of IntegraAr bilaminar dermal regeneration template in apert syndactyly reconstruction: a novel alternative to simplify care and improve outcomes. (21775231)
2012
8
A novel ZRS mutation in a Balochi tribal family with triphalangeal thumb, pre-axial polydactyly, post-axial polydactyly, and syndactyly. (22786669)
2012
9
A rare association of long QT syndrome and syndactyly: Timothy syndrome (LQT 8). (21915623)
2011
10
Correction of syndactyly using a dorsal separated V-Y advancement flap and a volar triangular flap in adults. (21301304)
2011
11
Megalencephaly, polymicrogyria, and hydrocephalus (MPPH) syndrome: a new case with syndactyly. (18474936)
2008
12
Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice. (18729207)
2008
13
An 8-month-old boy with cleft palate, microcephaly, developmental delay, and syndactyly. Smith-Lemili-Opitz syndrome. (17515167)
2007
14
Genetic analysis of syndactyly in German Holstein cattle. (16427589)
2006
15
Macrodactyly, syndactyly, and localized gigantism of the forefoot. A case report. (16878777)
2005
16
Contrary intermittent skin release of complete syndactyly without skin graft in adults. (16186698)
2005
17
Acquired syndactyly secondary to acrodermatitis continua of Hallopeau. (15888186)
2005
18
Cenani-Lenz syndactyly in a patient with features of Kabuki syndrome. (15194949)
2004
19
Clinical experience using the dorsal reverse metacarpal flap for the treatment of congenital syndactyly: report of four cases. (16518217)
2003
20
A case of a rare association of spastic paraplegia and type III syndactyly. (11784386)
2002
21
The open finger technique for release of syndactyly. (11560439)
2001
22
The open finger technique for the release of syndactyly. (11162004)
2001
23
Boy with syndactylies, macrocephaly, and severe skeletal dysplasia: not a new syndrome, but two dominant mutations (GLI3 E543X and COL2A1 G973R) in the same individual. (10678662)
2000
24
Genotype-phenotype analysis in Apert syndrome suggests opposite effects of the two recurrent mutations on syndactyly and outcome of craniofacial surgery. (10735635)
2000
25
Treatment of syndactyly. (16801754)
1998
26
Syndactyly release: results of the Flatt technique. (9828477)
1998
27
Identity-by-descent mapping of recessive traits in livestock: application to map the bovine syndactyly locus to chromosome 15. (8796345)
1996
28
In vitro model of syndactyly replicates the morphologic features observed in vivo. (7568495)
1995
29
A new form of long QT syndrome associated with syndactyly. (7798527)
1995
30
Distal aphalangia, syndactyly, and extra metatarsal, associated with short stature, microcephaly, and borderline intelligence: a new autosomal dominant disorder. (7717420)
1995
31
Ectodermal dysplasia with corkscrew hairs: observation of probable autosomal dominant tricho-odonto-onychodysplasia with syndactyly. (8141890)
1994
32
Surgical management of syndactyly in a dog. (7890572)
1994
33
Sclerocornea, hypertelorism, syndactyly, and ambiguous genitalia. (8116666)
1994
34
Type III syndactyly and oculodentodigital dysplasia: a clinical spectrum. (8110413)
1993
35
Nonadjacent syndactyly in the congenital constriction band syndrome. (1311343)
1992
36
Syndactyly type IV/hexadactyly of feet associated with unilateral absence of the tibia. (1654744)
1991
37
Surgical method for treatment of syndactyly with osseous fusion of the distal phalanges. (1845781)
1991
38
Local epidermoplasty for syndactyly. (1649142)
1991
39
Syndactyly. (2176654)
1990
40
Autosomal recessive ectodermal dysplasia, cleft lip/palate, mental retardation, and syndactyly: the Zlotogora-Ogur syndrome. (2167611)
1990
41
Hereditary bovine syndactyly: diagnosis in bovine fetuses. (3033869)
1987
42
Syndactyly induced by Janus Green B in the embryonic chick leg bud: a reexamination. (6099849)
1984
43
Syndactyly and split hand. Supplement. (213354)
1978
44
An operation for syndactyly, and its results. (185638)
1976
45
Management of burn syndactyly. (4367128)
1974
46
Micrognathia, hypodontia and syndactyly. (4375510)
1971
47
Mandibulo-facial dysostosis with syndactyly. (4319056)
1970
48
Bilateral ptosis and atypical slant eyes associated with unilateral syndactyly, adactyly and brachyphalangia. (20246987)
1946
49
Bilateral Ptosis and Atypical Slant Eyes Associated with Unilateral Syndactyly, Adactyly and Brachyphalangy. A Note on the Genetics of the Case. (19992848)
1944
50
Unusual Form of Syndactyly. (19983292)
1923

Variations for Syndactyly

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Expression for genes affiliated with Syndactyly

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Search GEO for disease gene expression data for Syndactyly.

Pathways for genes affiliated with Syndactyly

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Compounds for genes affiliated with Syndactyly

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GO Terms for genes affiliated with Syndactyly

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Biological processes related to Syndactyly according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Wnt signaling pathwayGO:00160559.1FBXW4, LRP4
2regulation of cell proliferationGO:00421279.1DHCR7, HOXD13
3embryonic digit morphogenesisGO:00427337.9LMBR1, FBXW4, LRP4, HOXD13

Products for genes affiliated with Syndactyly

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Sources for Syndactyly

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet