MCID: SYN001
MIFTS: 52

Syndactyly malady

Summaries for Syndactyly

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Syndactyly (from Greek συν- meaning \"together\" and δακτυλος meaning \"finger\") is a... more...

MalaCards: Syndactyly, also known as webbing of digits, is related to polydactyly and brachydactyly-syndactyly syndrome. An important gene associated with Syndactyly is GJA1 (gap junction protein, alpha 1, 43kDa), and among its related pathways is Hedgehog Signaling Pathway. The compound ay 9944 dihydrochloride have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes, and related mouse phenotypes are renal/urinary system and no phenotypic analysis.

Disease Ontology:8 A synostosis that results in the fusion of two or more digits.

Aliases & Classifications for Syndactyly

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8Disease Ontology, 10DISEASES, 44Novoseek, 56SNOMED-CT, 27ICD9CM, 60UMLS, 39NCIt, 34MeSH
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Aliases & Descriptions:

syndactyly 8 10 44
webbing of digits 8
polysyndactyly 8
syndactyly nos 8
symphalangism 8
symphalangy 8


External Ids:

Disease Ontology8 DOID:11193
ICD9CM27 755.1
NCIt39 C87125
MeSH34 D013576

Related Diseases for Syndactyly

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17GeneCards, 18GeneDecks
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Diseases in the Syndactyly Type 3 family:

syndactyly Syndactyly Type 9
Syndactyly Type 4 Syndactyly Type 1
Syndactyly Type 2 Syndactyly Type 5
Syndactyly Type 6

Diseases related to Syndactyly via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 393)
idRelated DiseaseScoreTop Affiliating Genes
1polydactyly30.6SHH, GLI3, HOXD13, HOXD11, HOXD12, DHCR7
2brachydactyly-syndactyly syndrome30.4LPCAT3, HOXD13
3brachydactyly30.3FAM58A, HOXD13
4pallister-hall syndrome29.9SHH, GLI3
5smith-lemli-opitz syndrome29.9DHCR7, SHH
6vacterl association29.6SHH, HOXD13
7triphalangeal thumb polysyndactyly syndrome10.4
8syndactyly type 310.3
9syndactyly type 510.3
10syndactyly type 910.3
11cleft palate10.3
12syndactyly cenani lenz type10.3
13thai symphalangism syndrome10.3
14cleft lip10.2
15acrocephalosyndactylia10.2
16craniosynostosis philadelphia type10.2
17syndactyly type 410.2
18synpolydactyly, type ii10.2
19microcephaly10.2
20poland syndrome10.2
21blepharophimosis with ptosis, syndactyly, and short stature10.2
22syndactyly type 110.2
23timothy syndrome10.2
24long qt syndrome10.2
25zygodactyly type 210.2
26zygodactyly type 310.2
27multiple synostoses syndrome 110.1
28symphalangism, distal, with microdontia, dental pulp stones, and narrowed zygomatic arch10.1
29tracheoesophageal fistula symphalangism10.1
30multiple synostosis syndrome 110.1
31kleiner holmes syndrome10.1
32short ribs craniosynostosis polysyndactyly10.1
33ectodermal dysplasia mental retardation syndactyly10.1
34syndactyly-polydactyly-earlobe syndrome10.1
35oculodentodigital dysplasia10.1
36star syndrome10.1
37burns10.1
38craniosynostosis10.1
39anophthalmos with limb anomalies10.1
40coronal synostosis, syndactyly and jejunal atresia10.1
41zlotogora syndrome10.1
42filippi syndrome10.1
43syndactyly type 210.1
44tricho odonto onychodysplasia syndactyly dominant type10.1
45zygodactyly 110.1
46syndactyly type 610.1
47premature ovarian failure10.1
48tarsal-carpal coalition syndrome10.1
49blaichman syndrome10.1
50sillence syndrome10.1

Graphical network of the top 20 diseases related to Syndactyly:



Diseases related to syndactyly

Clinical Features for Syndactyly

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Drugs & Therapeutics for Syndactyly

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Syndactyly

Drug clinical trials:

Search ClinicalTrials for Syndactyly

Search NIH Clinical Center for Syndactyly

Search CenterWatch for Syndactyly

Genetic Tests for Syndactyly

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Anatomical Context for Syndactyly

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32MalaCards
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MalaCards organs/tissues related to Syndactyly:

32
Skin, Eye, Testes, Kidney

Animal Models for Syndactyly or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Syndactyly:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.3SHH, GLI3, HOXD13, HOXD10, HOXD11, HOXD9
2MP:000301210.2GJA1, HOXD11, HOXD13, GLI3, SHH, FBXW4
3MP:000538010.2FBXW4, SHH, GLI3, HOXD13, HOXD11, HOXD12
4MP:000539010.2HOXD13, GLI3, SHH, FBXW4, HOXD10, HOXD11
5MP:000537110.2LMBR1, FBXW4, SHH, GLI3, HOXD13, HOXD10
6MP:001076810.1HOXD10, HOXD13, GLI3, SHH, FBXW4, HOXD11
7MP:000363110.1SHH, GLI3, HOXD13, HOXD10, HOXD11, HOXD9
8MP:000538910.0SHH, GLI3, HOXD13, HOXD10, HOXD11, HOXD9
9MP:00053699.9SHH, HOXD13, HOXD10, HOXD9, HOXD12, DHCR7

Publications for Syndactyly

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50PubMed
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Articles related to Syndactyly:

(show top 50)    (show all 406)
idTitleAuthorsYear
1
Bilateral macrodystrophia lipomatosa with syndactyly: a case report and literature review. (24164136)
2013
2
Treatment of congenital syndactyly of the fingers. (23970273)
2013
3
Genetic heterogeneity in type III familial cutaneous syndactyly and linkage to chromosome 7q36. (23686920)
2013
4
Toe syndactyly revisited. (20708986)
2011
5
Keloid formation after syndactyly release in patients with associated macrodactyly: management with methotrexate therapy. (21447529)
2011
6
Mutation in PVRL4 gene encoding nectin-4 underlies ectodermal-dysplasia-syndactyly syndrome (EDSS1). (21346770)
2011
7
Duplication at chromosome 2q31.1-q31.2 in a family presenting syndactyly and nystagmus. (21654727)
2011
8
Radial longitudinal deficiencies with hypoplastic/absent thumbs and cutaneous syndactyly of the most radial digits. (20807627)
2010
9
Laser ablation of abnormal skin pigmentation post syndactyly release. (20347411)
2010
10
Autosomal dominant syndrome of camptodactyly, clinodactyly, syndactyly, and bifid toes. (20683984)
2010
11
A modification of the Chinese island flap technique for simple incomplete syndactyly release. (19091737)
2009
12
Central ray deficiency with extensive syndactyly: a dilemma for classification. (19400540)
2009
13
V-M plasty and double Z-plasty: two versatile flaps for treatment of postburn syndactyly. (19730039)
2009
14
Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice. (18729207)
2008
15
Complex toe syndactyly with characteristic facial phenotype: a new syndrome? (18512233)
2008
16
Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome. (17236141)
2007
17
Expression of familial middle-ring-little finger syndactyly as either simple syndactyly or synpolydactyly. (16139401)
2006
18
Contrary intermittent skin release of complete syndactyly without skin graft in adults. (16186698)
2005
19
A simple method for characterising syndactyly in clinical practice. (16261692)
2005
20
Subcortical band heterotopia with simplified gyral pattern and syndactyly. (12749065)
2003
21
Oculo-dento-digital dysplasia (OMIM *164200). Full manifestation of the syndrome in a 9.5 year-old girl and type III syndactyly in the father. (12150221)
2002
22
A variant of Cenani-Lenz type syndactyly. (10756427)
2000
23
Anterior chamber eye anomalies, redundant skin and syndactyly--a new syndrome associated with breakpoints at 2q37.2 and 7q36.3. (10457847)
1999
24
Orodental abnormalities in lobster claw syndrome (a type of syndactyly). (10863501)
1999
25
Syndactyly in Apert syndrome. Utility of a prognostic classification. (10941391)
1999
26
Unknown syndrome in two male sibs with hypotonia, ptosis, hand malformations, 2/3 toes syndactyly, and mental retardation. (10422013)
1999
27
Hereditary syndactyly in Angus cattle. (9683073)
1998
28
Dermatoglyphics in patients with Cenani-Lenz type syndactyly: studies in a new case. (9182770)
1997
29
An autosomal dominant syndrome of renal and anogenital malformations with syndactyly. (8818947)
1996
30
Tissue expansion for Apert's syndactyly. (7561406)
1995
31
Fraser syndrome (cryptophthalmos [hidden eye]-syndactyly syndrome). (8648460)
1995
32
Synpolydactyly (type II syndactyly) with aplasia/hypoplasia of the middle phalanges of the toes: report on a family with eight affected members in four generations. (7717427)
1995
33
Surgical management of syndactyly in a dog. (7890572)
1994
34
Nonadjacent syndactyly in the congenital constriction band syndrome. (1311343)
1992
35
A pedigree of cervical stenosis, brachydactyly, syndactyly, and hyperopia. (2551554)
1989
36
Type II syndactyly or synpolydactyly. (3014149)
1986
37
Early surgical intervention in Apert's syndactyly. (3511483)
1986
38
Isolated hypogonadotropic hypogonadism with syndactyly. (6093725)
1984
39
A fortuitous donor site for full-thickness skin grafts in the correction of syndactyly. (6318873)
1984
40
Apparent bifurcatio of distal humerous with oligoectro-syndactyly. (6305194)
1983
41
Present nosology of the Cenani-Lenz type of syndactyly. (6279340)
1982
42
A family with syndactyly type II (synpolydactyly). (199388)
1977
43
Syndactyly and split hand. (181296)
1976
44
The cryptophthalmos-syndactyly syndrome. Description, manner of inheritance, and notes on the eye lesions. (4360847)
1974
45
Documentation of syndactyly and Treacher Collins syndrome for possible concomitant speech disorders. (4325160)
1971
46
Syndactyly with ipsilateral chest deformity. (4317637)
1970
47
Asymmetric manifestations of an apparently new syndrome: depressed and pitted skin, facial tumors, syndactyly, and other congenital defects. (4386914)
1968
48
Repair of congenital finger syndactyly. (13487146)
1957
49
Acrocephaly-syndactyly. (21065302)
1946
50
An unusual form of Brachyphalangy and Syndactyly, with Double Proximal Phalanx in the Middle Fingers. (17104406)
1932

Genetic Variations for Syndactyly

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Expression for genes affiliated with Syndactyly

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Syndactyly

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Pathways for genes affiliated with Syndactyly

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37NCBI BioSystems Database, 59Tocris Bioscience
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Pathways related to Syndactyly according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4GLI3, SHH

Compounds for genes affiliated with Syndactyly

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59Tocris Bioscience
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Compounds related to Syndactyly according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ay 9944 dihydrochloride5910.4DHCR7, SHH

GO Terms for genes affiliated with Syndactyly

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16Gene Ontology
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Biological processes related to Syndactyly according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of alpha-beta T cell differentiationGO:04663910.8SHH, GLI3
2hindgut morphogenesisGO:00744210.7GLI3, SHH
3artery developmentGO:06084010.7SHH, GLI3
4metanephros developmentGO:00165610.7HOXD11, GLI3, SHH
5embryonic limb morphogenesisGO:03032610.7FBXW4, SHH, HOXD10
6dorsal/ventral pattern formationGO:00995310.7LRP4, HOXD11, SHH
7positive regulation of alpha-beta T cell differentiationGO:04663810.7GLI3, SHH
8embryonic skeletal system morphogenesisGO:04870410.7HOXD9, HOXD10, GLI3
9embryonic forelimb morphogenesisGO:03511510.7SHH, HOXD11, HOXD9
10hindlimb morphogenesisGO:03513710.7HOXD9, HOXD10
11odontogenesis of dentin-containing toothGO:04247510.7LRP4, GLI3, SHH
12branching involved in ureteric bud morphogenesisGO:00165810.7SHH, GLI3, HOXD11
13peripheral nervous system neuron developmentGO:04893510.7HOXD9, HOXD10
14lung developmentGO:03032410.7SHH, GLI3, DHCR7
15negative thymic T cell selectionGO:04506010.7GLI3, SHH
16limb bud formationGO:06017410.7GJA1, SHH
17proximal/distal pattern formationGO:00995410.6GLI3, HOXD10, HOXD11, HOXD9, LRP4
18negative regulation of canonical Wnt receptor signaling pathwayGO:09009010.6SHH, GLI3, LRP4
19positive regulation of protein import into nucleusGO:04230710.6SHH, GLI3
20anterior/posterior pattern specificationGO:00995210.6SHH, GLI3, HOXD13, HOXD10, HOXD11, HOXD9
21regulation of cell proliferationGO:04212710.6DHCR7, HOXD13, SHH
22positive regulation of chondrocyte differentiationGO:03233210.6GLI3, HOXD11
23phosphatidylserine acyl-chain remodelingGO:03615010.6LPCAT3, MBOAT1
24positive regulation of neuroblast proliferationGO:00205210.5GLI3, SHH
25embryonic digit morphogenesisGO:04273310.5LMBR1, FBXW4, SHH, GLI3, HOXD13, HOXD11
26male genitalia developmentGO:03053910.5HOXD13, SHH
27T cell differentiation in thymusGO:03307710.4GLI3, SHH
28phosphatidylethanolamine acyl-chain remodelingGO:03615210.4LPCAT3, MBOAT1
29positive regulation of transcription from RNA polymerase II promoterGO:04594410.3SHH, GLI3, HOXD13, HOXD10, HOXD9
30heart developmentGO:00750710.3SHH, GLI3, GJA1
31developmental growthGO:04858910.1HOXD11, GLI3

Molecular functions related to Syndactyly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:00370010.2HOXD13, HOXD10, HOXD11, HOXD9, HOXD12, GLI3
2sequence-specific DNA bindingGO:0435659.9HOXD12, HOXD9, HOXD11, HOXD10, HOXD13, GLI3

Products for genes affiliated with Syndactyly

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Sources for Syndactyly

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
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50PubMed
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57SNOMED-CT via Orphanet
60UMLS
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