MCID: SYN001
MIFTS: 50

Syndactyly malady

Genetic diseases, Bone diseases, Rare diseases, Fetal diseases categories

Summaries for Syndactyly

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 Syndactyly (from Greek ???- meaning \"together\" and ???????? meaning \"finger\") is a condition wherein... more...

MalaCards: Syndactyly, also known as webbing of digits, is related to polydactyly and brachydactyly. An important gene associated with Syndactyly is GJA1 (gap junction protein, alpha 1, 43kDa). Affiliated tissues include skin, eye and bone, and related mouse phenotypes are embryogenesis and skeleton.

Disease Ontology:9 A synostosis that results in the fusion of two or more digits.

Aliases & Classifications for Syndactyly

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Fetal diseases
Anatomical: Bone diseases


Aliases & Descriptions:

syndactyly 9 11 46
webbing of digits 9
polysyndactyly 9
syndactyly nos 9
symphalangism 9
symphalangy 9


External Ids:

Disease Ontology9 DOID:11193
ICD9CM28 755.1
NCIt41 C87125
MeSH36 D013576

Related Diseases for Syndactyly

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18GeneCards, 19GeneDecks
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Diseases in the Syndactyly Type 3 family:

syndactyly Syndactyly Type 1
Syndactyly Type 2 Syndactyly Type 4
Syndactyly Type 5 Syndactyly Type 9
Syndactyly Type 6

Diseases related to Syndactyly via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 432)
idRelated DiseaseScoreTop Affiliating Genes
1polydactyly30.6HOXD13, LMBR1, DHCR7
2brachydactyly30.3HOXD13, FAM58A
3atrioventricular septal defect29.7DHCR7
4cryptophthalmos10.4
5mental retardation10.4
6syndactyly type 310.3
7syndactyly type 510.3
8ectodermal dysplasia10.3
9syndactyly type 910.3
10thai symphalangism syndrome10.3
11brachydactyly-syndactyly syndrome10.3
12oculodentodigital dysplasia10.3
13syndactyly cenani lenz type10.3
14syndactyly type 110.3
15cleft lip10.3
16craniosynostosis philadelphia type10.3
17synpolydactyly, type ii10.3
18fraser syndrome10.3
19syndactyly type 410.3
20poland syndrome10.2
21microcephaly10.2
22acrocephalosyndactylia10.2
23blepharophimosis with ptosis, syndactyly, and short stature10.2
24timothy syndrome10.2
25keloids10.2
26keloid formation10.2
27zygodactyly type 210.2
28zygodactyly type 310.2
29multiple synostoses syndrome 110.2
30symphalangism, distal, with microdontia, dental pulp stones, and narrowed zygomatic arch10.2
31tracheoesophageal fistula symphalangism10.2
32kleiner holmes syndrome10.2
33short ribs craniosynostosis polysyndactyly10.2
34long qt syndrome10.2
35anophthalmos with limb anomalies10.2
36ectodermal dysplasia mental retardation syndactyly10.2
37filippi syndrome10.2
38star syndrome10.2
39syndactyly-polydactyly-earlobe syndrome10.2
40burns10.1
41coronal synostosis, syndactyly and jejunal atresia10.1
42syndactyly type 210.1
43zlotogora syndrome10.1
44triphalangeal thumb10.1
45zygodactyly 110.1
46short stature10.1
47ectodermal dysplasia - cutaneous syndactyly syndrome10.1
48syndactyly type 610.1
49premature ovarian failure10.1
50tarsal-carpal coalition syndrome10.1

Graphical network of the top 20 diseases related to Syndactyly:



Diseases related to syndactyly

Symptoms for Syndactyly

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Drugs & Therapeutics for Syndactyly

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Syndactyly

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Anatomical Context for Syndactyly

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34MalaCards
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MalaCards organs/tissues related to Syndactyly:

34
Skin, Eye, Bone, Testes, Kidney

Animal Models for Syndactyly or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Syndactyly:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.2GJA1, FBXW4, LRP4, HOXD13
2MP:00053907.6GJA1, HOXD13, LMBR1, FBXW4, LRP4
3MP:00053787.4HOXD13, LRP4, LMBR1, DHCR7, GJA1
4MP:00053717.3GJA1, DHCR7, LMBR1, FBXW4, LRP4, HOXD13
5MP:00107687.1LMBR1, GJA1, HOXD13, LRP4, DHCR7, FBXW4

Publications for Syndactyly

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53PubMed
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Articles related to Syndactyly:

(show top 50)    (show all 403)
idTitleAuthorsYear
1
Formation of normal interdigital web spaces in the hand revisited: implications for the pathogenesis of syndactyly in humans and experimental animals. (23719174)
2013
2
Bilateral macrodystrophia lipomatosa with syndactyly: a case report and literature review. (24164136)
2013
3
Long-term aesthetic outcome of fingertip reconstruction in complete syndactyly release. (23027834)
2013
4
Treatment of congenital syndactyly of the fingers. (23970273)
2013
5
The use of IntegraAr bilaminar dermal regeneration template in apert syndactyly reconstruction: a novel alternative to simplify care and improve outcomes. (21775231)
2012
6
A novel ZRS mutation in a Balochi tribal family with triphalangeal thumb, pre-axial polydactyly, post-axial polydactyly, and syndactyly. (22786669)
2012
7
Ectodermal dysplasia with syndactyly. (22565451)
2012
8
A rare association of long QT syndrome and syndactyly: Timothy syndrome (LQT 8). (21915623)
2011
9
Correction of syndactyly using a dorsal separated V-Y advancement flap and a volar triangular flap in adults. (21301304)
2011
10
Megalencephaly, polymicrogyria, and hydrocephalus (MPPH) syndrome: a new case with syndactyly. (18474936)
2008
11
Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice. (18729207)
2008
12
An 8-month-old boy with cleft palate, microcephaly, developmental delay, and syndactyly. Smith-Lemili-Opitz syndrome. (17515167)
2007
13
Genetic analysis of syndactyly in German Holstein cattle. (16427589)
2006
14
Macrodactyly, syndactyly, and localized gigantism of the forefoot. A case report. (16878777)
2005
15
Contrary intermittent skin release of complete syndactyly without skin graft in adults. (16186698)
2005
16
Acquired syndactyly secondary to acrodermatitis continua of Hallopeau. (15888186)
2005
17
Cenani-Lenz syndactyly in a patient with features of Kabuki syndrome. (15194949)
2004
18
Clinical experience using the dorsal reverse metacarpal flap for the treatment of congenital syndactyly: report of four cases. (16518217)
2003
19
A case of a rare association of spastic paraplegia and type III syndactyly. (11784386)
2002
20
The open finger technique for release of syndactyly. (11560439)
2001
21
The open finger technique for the release of syndactyly. (11162004)
2001
22
Boy with syndactylies, macrocephaly, and severe skeletal dysplasia: not a new syndrome, but two dominant mutations (GLI3 E543X and COL2A1 G973R) in the same individual. (10678662)
2000
23
Genotype-phenotype analysis in Apert syndrome suggests opposite effects of the two recurrent mutations on syndactyly and outcome of craniofacial surgery. (10735635)
2000
24
Treatment of syndactyly. (16801754)
1998
25
Syndactyly release: results of the Flatt technique. (9828477)
1998
26
Concomitant syndactyly and polydactyly in a pediatric foot. (9127221)
1997
27
Identity-by-descent mapping of recessive traits in livestock: application to map the bovine syndactyly locus to chromosome 15. (8796345)
1996
28
In vitro model of syndactyly replicates the morphologic features observed in vivo. (7568495)
1995
29
A new form of long QT syndrome associated with syndactyly. (7798527)
1995
30
Distal aphalangia, syndactyly, and extra metatarsal, associated with short stature, microcephaly, and borderline intelligence: a new autosomal dominant disorder. (7717420)
1995
31
Ectodermal dysplasia with corkscrew hairs: observation of probable autosomal dominant tricho-odonto-onychodysplasia with syndactyly. (8141890)
1994
32
Surgical management of syndactyly in a dog. (7890572)
1994
33
Sclerocornea, hypertelorism, syndactyly, and ambiguous genitalia. (8116666)
1994
34
Type III syndactyly and oculodentodigital dysplasia: a clinical spectrum. (8110413)
1993
35
Nonadjacent syndactyly in the congenital constriction band syndrome. (1311343)
1992
36
Syndactyly type IV/hexadactyly of feet associated with unilateral absence of the tibia. (1654744)
1991
37
Surgical method for treatment of syndactyly with osseous fusion of the distal phalanges. (1845781)
1991
38
Local epidermoplasty for syndactyly. (1649142)
1991
39
Syndactyly. (2176654)
1990
40
Autosomal recessive ectodermal dysplasia, cleft lip/palate, mental retardation, and syndactyly: the Zlotogora-Ogur syndrome. (2167611)
1990
41
Hereditary bovine syndactyly: diagnosis in bovine fetuses. (3033869)
1987
42
Syndactyly induced by Janus Green B in the embryonic chick leg bud: a reexamination. (6099849)
1984
43
Syndactyly and split hand. Supplement. (213354)
1978
44
An operation for syndactyly, and its results. (185638)
1976
45
Management of burn syndactyly. (4367128)
1974
46
Micrognathia, hypodontia and syndactyly. (4375510)
1971
47
Mandibulo-facial dysostosis with syndactyly. (4319056)
1970
48
Bilateral ptosis and atypical slant eyes associated with unilateral syndactyly, adactyly and brachyphalangia. (20246987)
1946
49
Bilateral Ptosis and Atypical Slant Eyes Associated with Unilateral Syndactyly, Adactyly and Brachyphalangy. A Note on the Genetics of the Case. (19992848)
1944
50
Unusual Form of Syndactyly. (19983292)
1923

Variations for Syndactyly

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Expression for genes affiliated with Syndactyly

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Syndactyly

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Pathways for genes affiliated with Syndactyly

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Compounds for genes affiliated with Syndactyly

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GO Terms for genes affiliated with Syndactyly

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17Gene Ontology
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Biological processes related to Syndactyly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Wnt signaling pathwayGO:0160559.1FBXW4, LRP4
2regulation of cell proliferationGO:0421279.1DHCR7, HOXD13
3embryonic digit morphogenesisGO:0427337.9LMBR1, FBXW4, LRP4, HOXD13

Products for genes affiliated with Syndactyly

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Sources for Syndactyly

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet