Syndactyly malady

Wikipedia: Syndactyly (from Greek συν- = \"together\" plus δακτυλος = \"finger\") is a condition wherein...⁴⁴ more...

MalaCards: Syndactyly, also known as symphalangism, is related to cushing's symphalangism and brachydactyly-syndactyly syndrome. An important gene associated with Syndactyly is SDTY1 (Syndactyly, type I), and among its related pathways are Basal cell carcinoma and Hedgehog signaling pathway. The compounds pd 161570 and su5402 have been mentioned in the context of this disorder. Affiliated tissues include t cells and b cells, and related mouse phenotypes are craniofacial and respiratory system.

Disease Ontology: A synostosis that results in the fusion of two or more digits.⁶

Aliases & Descriptions:

syndactyly 6 7 8 32 symphalangism 6 7 symphalangy (disorder) 6

webbing of digits 6 polysyndactyly 6 syndactyly nos 6

Disease types for syndactyly family:

syndactyly type 1	syndactyly type 2
syndactyly type 3	syndactyly type 4
syndactyly type 5	syndactyly type 9

Diseases related to syndactyly by text searches and GeneDecks gene sharing:

(show top 50)    (show all 187)

id	Related Disease	Score	Top Affiliating Genes
1	cushing's symphalangism	32.7	NOG, GDF5
2	brachydactyly-syndactyly syndrome	31.1	HOXD13, HOXD12, HOXD11, CASD1, MBOAT1, LPCAT3
3	synpolydactyly	30.7	HOXD12, HOXD13, HOXD9, EVX2, HOXD11, HOXD10
4	acrocephalosyndactylia	30.7	FGF10, FGFR1, FGFR2, FGFR3
5	saethre-chotzen syndrome	29.8	FGFR3, FGFR2, FGFR1, MSX2
6	brachydactyly type b	28.8	ROR2, NOG
7	ectodermal dysplasia	28.4	PVRL1, PVRL4, FGF10, DLX2, FGFR2, FGFR3
8	zygodactyly	27.9	SDTY1, HOXD13
9	triphalangeal thumb	27.9	LMBR1, SHH, HOXD13
10	thanatophoric dysplasia	27.8	FGFR2, FGFR3
11	brachydactyly	27.5	GDF5, OFD1, NOG, COL2A1, SHH, EPHA7
12	triphalangeal thumb-polysyndactyly syndrome	27.5	SHH, LMBR1
13	pallister-hall syndrome	27.4	SHH, GLI3, KIF7, PTCH1
14	infectious mononucleosis	27.0	FGFR3, FGFR2, FGFR1, FGF10, FGF8
15	smith-lemli-opitz syndrome	26.6	DHCR7, SHH, KIF7
16	fraser syndrome	26.1	GRIP1, FREM2, FREM1, FRAS1, FREM3
17	ectrodactyly	26.0	SHFM1, DHCR7, PORCN, ARHGAP31, FGF8, FBXW4
18	synostosis	25.8	MSX2, ATRNL1, FGF10, FGFR1, FGFR2, FGFR3
19	polydactyly	25.6	HOXD11, GDF5, SALL1, PTCH1, LMBR1, KIF7
20	cleft palate	24.7	SHH, PVRL1, DHCR7, COL2A1, FGF8, NOG
21	craniosynostosis	24.1	IHH, FGFR2, GLI3, DLX5, NOG, FBN1
22	talipes equinovarus	13.7	HOXD13, HOXD12, HOXD10, GLI3
23	hay-wells syndrome	13.7	FGFR2, TP63
24	acheiropody	13.7	LMBR1, ZP2
25	acrocallosal syndrome	13.7	KIF7, IHH, GLI3
26	crouzonodermoskeletal syndrome	13.6	FGFR3, FGFR2
27	tracheoesophageal fistula	13.6	GLI3, SHH, NOG, HOXD13
28	split hand/foot malformation	13.6	FBXW4, TP63, SHFM1, WNT10B
29	ladd syndrome	13.6	FGF10, FGFR3, FGFR2
30	brachydactyly type a1	13.6	IHH, SHH, GDF5
31	hypodontia	13.6	TP63, FGFR2, FGFR3, FGF10
32	enlarged parietal foramina	13.5	ALX4, MSX2
33	cutis marmorata telangiectatica congenita	13.5	ARHGAP31, DOCK6, ALX4
34	skin benign neoplasm	13.5	GJA1, FGFR3, PTCH1, TP63
35	jackson-weiss syndrome	13.5	FGFR3, FGFR1, FGFR2
36	beare-stevenson cutis gyrata syndrome	13.5	FGFR3, FGFR2
37	fgfr-related craniosynostosis syndromes	13.5	FGFR3, FGFR1, FGFR2
38	esophageal atresia	13.5	SHH, GLI3, FGF10, NOG
39	contractural arachnodactyly	13.5	FGFR2, FBN2, FBN1
40	osteoglophonic dysplasia	13.5	FGFR3, FGFR2, FGFR1
41	aorta atresia	13.4	FGF10, GJA1, FGFR2
42	focal dermal hypoplasia	13.4	PORCN, OFD1, PTCH1
43	muenke syndrome	13.4	FGFR2, FGFR1, FGFR3
44	plagiocephaly	13.4	FGFR3, FGFR1, FGFR2
45	cockayne syndrome	13.4	FGFR3, FGFR1, FGFR2
46	hypochondroplasia	13.4	FGFR1, FGFR2, FGFR3
47	hirschsprung's disease	13.4	DHCR7, GJA1, LAMA5, IHH, HOXD9
48	marfan syndrome	13.4	FBN1, FBN2
49	birth defects	13.4	GLI3, TP63, SALL1, ARHGAP31, PVRL1
50	autosomal dominant disease	13.3	PTCH1, ALX4, FGFR3, MSX2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to syndactyly:

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MGI Mouse Phenotypes related to syndactyly:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial phenotype	MP:0005382	INF	LRP4, SFRP2, LAMA5, GLI3, HOXD1, GJA1
2	respiratory system phenotype	MP:0005388	INF	TP63, PTCH1, DLX2, , OFD1, NOG
3	embryogenesis phenotype	MP:0005380	INF	FBN1, OFD1, SMOC1, NOG, COL2A1, SHH
4	limbs/digits/tail phenotype	MP:0005371	INF	MSX2, FRAS1, FREM1, FREM2, FGF10, FGF8
5	integument phenotype	MP:0010771	INF	PTCH1, TP63, GJA1, HOXD9, HOXD13,
6	digestive/alimentary phenotype	MP:0005381	INF	FGF8, FGFR1, FGFR2, FGFR3, IL11RA, IHH
7	pigmentation phenotype	MP:0001186	8.9	PTCH1, GLI3, FBN1, FGFR2, FREM2, MSX2
8	other phenotype	MP:0005395	8.4	GJA1, GLI3, FBN1, IL11RA, FRAS1, LAMA5
9	no phenotypic analysis	MP:0003012	8.3	HOXD11, HOXD13, GJA1, PTCH1, DLX1, SHH
10	endocrine/exocrine gland phenotype	MP:0005379	7.5	HOXD9, GJA1, TP63, PTCH1, NOG, SHH
11	reproductive system phenotype	MP:0005389	7.1	HOXD12, HOXD13, HOXD9, GJA1, TP63, PTCH1
12	homeostasis/metabolism phenotype	MP:0005376	6.9	GJA1, TP63, DLX2, CRIM1, NOG, SHH
13	renal/urinary system phenotype	MP:0005367	5.5	LRP4, LAMA5, SALL1, FRAS1, FREM1, HOXD13
14	skeleton phenotype	MP:0005390	5.3	FREM2, FGF10, FGF8, FGFR1, FGFR2, FGFR3
15	growth/size phenotype	MP:0005378	INF	SALL1, FBN2, IHH, ALX4, GLI3, EVX2
16	behavior/neurological phenotype	MP:0005386	INF	HOXD9, GJA1, TP63, PTCH1, DLX2,
17	cardiovascular system phenotype	MP:0005385	INF	DLX2, DLX1, PTCH1, TP63, GJA1, GLI3
18	mortality/aging	MP:0010768	INF	DHCR7, PORCN, ROR2, , WNT9A, GDF5
19	hearing/vestibular/ear phenotype	MP:0005377	INF	DLX1, DLX2, , NOG, COL2A1, SHH
20	vision/eye phenotype	MP:0005391	INF	FGFR2, CRIM1, NOG, COL2A1, SHH, PVRL1
21	normal phenotype	MP:0002873	INF	GJA1, TP63, PTCH1, , NOG, COL2A1
22	cellular phenotype	MP:0005384	INF	, DLX1, PTCH1, TP63, HOXD9, OFD1
23	taste/olfaction phenotype	MP:0005394	INF	SHH, NOG, , TP63, GLI3
24	nervous system phenotype	MP:0003631	INF	FGF10, HOXD10, HOXD11, HOXD12, HOXD13, HOXD9
25	muscle phenotype	MP:0005369	INF	PTCH1, TP63, GJA1, HOXD9, DLX2,

Articles related to syndactyly:

(show all 28)

id	Title	Authors	Year	Affiliating Genes
1	Copy-number variations involving the IHH locus are as sociated with syndactyly and craniosynostosis. (21167467)	Klopocki E.... Mundlos S.	2011	IHH
2	Mutations in gene PVRL4 encoding for cell adhesion m olecule Nectin-4 in ectodermal dysplasia-syndactyly syndrome]. (21333831)	Dereure O.	2011	PVRL4
3	Mutation in PVRL4 gene encoding nectin-4 underlies ec todermal-dysplasia-syndactyly syndrome (EDSS1). (21346770)	Jelani M.... Ahmad W.	2011	PVRL4
4	Mutations in PVRL4, encoding cell adhesion molecule n ectin-4, cause ectodermal dysplasia-syndactyly syndrome. (20691405)	Brancati F.... Dallapiccola B.	2010	PVRL4
5	A ZRS duplication causes syndactyly type IV with tibi al hypoplasia. (19291772)	Wu L.... Xia J.	2009	SHH
6	A novel single-base deletion in ROR2 causes atypical brachydactyly type B1 with cutaneous syndactyly in a large Chinese family. (19461659)	Lv D.... Zhang X.	2009	ROR2
7	Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice. (18729207)	Ikegawa M.... Tashiro K.	2008	SFRP2
8	A novel mutation of p63 in a Chinese family with inherited syndactyly and adactylism. (17915261)	Luo T.... Wu X.	2008	TP63
9	Mutations in the cyclin family member FAM58A cause an X-linked dominant disorder characterized by syndactyly, telecanthus and anogenital and renal malformations. (18297069)	Unger S.... Kohlhase J.	2008	SALL1, FAM58A
10	Triphalangeal thumb-polysyndactyly syndrome and syndactyly type IV are caused by genomic duplications involving the long range, limb- specific SHH enhancer. (18417549)	Sun M.... Zhang X.	2008	SHH, LMBR1
11	Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome. (17236141)	Zhao X.... Zhang X.	2007	EPHA7, HOXD10, HOXD13
12	Oculodentodigital dysplasia with mandibular retrognathism and absence of syndactyly: a case report with a novel mutation in the connexin 43 gene. (17509830)	van Es R.J.J.... Beemer F.A.	2007	GJA1
13	A t(4;6)(q12;p23) translocation disrupts a membrane-associated O-acetyl transferase gene (MBOAT1) in a patient with a novel brachydactyly-syndactyly syndrome. (17440500)	Dauwerse J.G.... Peters D.J.	2007	MBOAT1
14	A syndactyly type IV locus maps to 7q36. (17476456)	Sato D.... Niikawa N.	2007	SHH
15	The bovine aristaless-like homeobox 4 (ALX4) as a candidate gene for syndactyly. (17065792)	Wohlke A.... Drogemuller C.	2006	ALX4
16	Autosomal recessive mesoaxial synostotic syndactyly with phalangeal reduction maps to chromosome 17p13.3. (15779011)	Malik S.... Grzeschik K.H.	2005	MSSD
17	A novel GJA1 mutation causes oculodentodigital dysplasia without syndactyly. (15637728)	Vitiello C.... Banfi S.	2005	GJA1
18	Expression of Gja1 correlates with the phenotype observed in oculodentodigital syndrome/type III syndactyly. (14729836)	Richardson R.R.... Dixon M.J.	2004	GJA1
19	Confirmation of genetic homogeneity of syndactyly type 1 in an Iranian family. (11746046)	Ghadami M.... Niikawa N.	2001	SDTY1
20	Mutation of the gene encoding fibrillin-2 results in syndactyly in mice. (11285249)	Chaudhry S.S.... Dixon M.J.	2001	FBN1, FBN2
21	Genotype-phenotype analysis in Apert syndrome suggests opposite effects of the two recurrent mutations on syndactyly and outcome of craniofacial surgery. (10735635)	von Gernet S.... Fairley J.D.	2000	FGFR2
22	Localization of a gene for syndactyly type 1 to chromosome 2q34-q36. (10877983)	Bosse K.... Nothen M.M.	2000	SDTY1
23	Boy with syndactylies, macrocephaly, and severe skeletal dysplasia: not a new syndrome, but two dominant mutations (GLI3 E543X and COL2A1 G973R) in the same individual. (10678662)	Sobetzko D.... Superti-Furga A.	2000	COL2A1, GLI3
24	Presence of the Apert canonical S252W FGFR2 mutation in a patient without severe syndactyly. (9719378)	Passos-Bueno M.R.... Kneppers A.	1998	FGFR2
25	Thanatophoric dysplasia type I with syndactyly. (9843049)	Brodie S.G.... Wilcox W.R.	1998	FGFR3, FGFR2
26	Differential effects of FGFR2 mutations on syndactyly and cleft palate in Apert syndrome. (8651276)	Slaney S.F.... Wilkie A.O.	1996	FGFR2
27	A large Turkish kindred with syndactyly type II (synpolydactyly). 1. Field investigation, clinical and pedigree data. (7666393)	Sayli B.S.... Sarfarazi M.	1995	HOXD13
28	Localization of the syndactyly type II (synpolydactyly) locus to 2q31 region and identification of tight linkage to HOXD8 intragenic marker. (7581388)	Sarfarazi M.... Sayli B.S.	1995	HOXD13, EVX2

Genes related to syndactyly according to GeneCards:

(show top 50)    (show all 68)

id	Symbol	Description	Score	GeneCards Section Context
1	SDTY1	Syndactyly, type I	11.1	Aliases & Descriptions, Publications
2	FAM58A	family with sequence similarity 58, member A	11.1	Disorders, Summaries, Publications
3	PVRL4	poliovirus receptor-related 4	11.1	Summaries, Publications
4	EDSS2	Ectodermal dysplasia-syndactyly syndrome 2	11.0	Aliases & Descriptions
5	FBXW4	F-box and WD repeat domain containing 4	11.0	Summaries
6	DHCR7	7-dehydrocholesterol reductase	11.0	Summaries
7	MSSD	syndactyly, mesoaxial synostotic, with phalangeal reduction	11.0	Publications, Aliases & Descriptions
8	HOXD13	homeobox D13	11.0	Publications, UniProt Related
9	GJA1	gap junction protein, alpha 1, 43kDa	11.0	Publications
10	LMBR1	limb region 1 homolog (mouse)	11.0	Publications
11	HOXD11	homeobox D11	11.0	Publications
12	HOXD12	homeobox D12	11.0	Publications
13	HOXD10	homeobox D10	11.0	Publications
14	HOXD9	homeobox D9	11.0	Publications
15	LRP4	low density lipoprotein receptor-related protein 4	11.0
16	MBOAT1	membrane bound O-acyltransferase domain containing 1	11.0	Publications
17	EPHA7	EPH receptor A7	11.0	Publications
18	GLI3	GLI family zinc finger 3	11.0	Publications
19	FGFR2	fibroblast growth factor receptor 2	11.0	Publications
20	FBN2	fibrillin 2	11.0	Publications
21	FGFR3	fibroblast growth factor receptor 3	11.0	Publications
22	TP63	tumor protein p63	11.0	Publications
23	GRIP1	glutamate receptor interacting protein 1	11.0
24	EVX2	even-skipped homeobox 2	11.0	Publications
25	MIR17HG	miR-17-92 cluster host gene (non-protein coding)	11.0
26	HOXD1	homeobox D1	11.0
27	PORCN	porcupine homolog (Drosophila)	11.0
28	IHH	Indian hedgehog	11.0	Publications
29	WNT10B	wingless-type MMTV integration site family, member 10B	11.0
30	DLX2	distal-less homeobox 2	11.0
31	DLX1	distal-less homeobox 1	11.0
32	ZP2	zona pellucida glycoprotein 2 (sperm receptor)	11.0	Disorders
33	OFD1	oral-facial-digital syndrome 1	11.0
34	SALL1	sal-like 1 (Drosophila)	11.0	Publications
35	WNT9A	wingless-type MMTV integration site family, member 9A	11.0
36	NOG	noggin	11.0
37	SFRP2	secreted frizzled-related protein 2	11.0	Publications
38	IL11RA	interleukin 11 receptor, alpha	11.0
39	KIF7	kinesin family member 7	11.0
40	SHH	sonic hedgehog	11.0	Publications
41	SOST	sclerostin	11.0
42	ALX4	ALX homeobox 4	11.0	Publications
43	SHFM1	split hand/foot malformation (ectrodactyly) type 1	11.0
44	EIF6	eukaryotic translation initiation factor 6	11.0
45	DOCK6	dedicator of cytokinesis 6	11.0
46	CASD1	CAS1 domain containing 1	11.0
47	LPCAT3	lysophosphatidylcholine acyltransferase 3	11.0	Disorders
48	AZGP1	alpha-2-glycoprotein 1, zinc-binding	11.0
49	ARHGAP31	Rho GTPase activating protein 31	11.0
50	FGF8	fibroblast growth factor 8 (androgen-induced)	11.0

Pathways related to syndactyly according to GeneDecks:

(show all 50)

id	Pathway	Score	Top Affiliating Genes
1	Basal cell carcinoma20	10.2	WNT9A, WNT10B, SHH, PTCH1, GLI3
2	Hedgehog signaling pathway20	10.1	WNT9A, WNT10B, SHH, PTCH1, GLI3, IHH
3	Development Hedgehog and PTH signaling pathways in bone and cartilage development10	10.1	SHH, COL2A1, PTCH1, IHH
4	Signaling by EGFR38	10.0	FGFR3, FGFR2, FGF8, FGF10
5	Actin-Based Motility by Rho Family GTPases36	10.0	FGF10, FGFR3, GDF5
6	Development FGF-family signaling10	10.0	FGFR3, FGFR2, FGFR1, FGF8, FGF10
7	Development_FGF-family signaling41	9.9	FGFR3, FGFR2, FGFR1, FGF8, FGF10
8	FGF Pathway36	9.9	FGFR3, FGFR2, FGFR1, FGF8, FGF10
9	RhoGDI Pathway36	9.7	FGFR3, FGFR2, FGFR1, FGF8, FGF10
10	JNK Pathway36	9.7	GDF5, ROR2, FGFR3, FGFR2, FGFR1
11	Apoptotic Pathways in Synovial Fibroblasts36	9.7	GDF5, FGFR3, FGFR2, FGFR1, FGF8, FGF10
12	p53 Mediated Apoptosis36	9.6	GDF5, FGFR3, FGFR2, FGFR1, FGF8, FGF10
13	Telomerase Components in Cell Signaling36	9.6	GDF5, FGFR3, FGFR2, FGFR1, FGF8, FGF10
14	Nuclear Receptor Activation by Vitamin-A36	9.6	GDF5, GRIP1, FGFR3, FGFR2, FGFR1, FGF8
15	Mitochondrial Apoptosis36	9.6	GDF5, FGFR3, FGFR2, FGFR1, FGF8, FGF10
16	NF-KappaB (p50-p65) Pathway36	9.5	GDF5, FGFR3, FGFR2, FGFR1, FGF8, FGF10
17	P2Y Receptor Signaling36	9.5	EPHA7, ROR2, FGFR3, FGFR2, FGFR1, FGF8
18	DHA Signaling36	9.5	GDF5, FGFR3, FGFR2, FGFR1, FGF8, FGF10
19	NF-KappaB Family Pathway36	9.5	GDF5, FGFR3, FGFR2, FGFR1, FGF8, FGF10
20	ERK5 Signaling36	9.5	GDF5, FGFR3, FGFR2, FGFR1, FGF8, FGF10
21	Cellular Apoptosis Pathway36	9.4	GDF5, FGFR3, FGFR2, FGFR1, FGF8, FGF10
22	Actin Nucleation and Branching36	9.4	EPHA7, ROR2, FGFR3, FGFR2, FGFR1
23	PPAR Pathway36	9.4	GDF5, FGFR3, FGFR2, FGFR1, FGF8, FGF10
24	Paxillin Interactions36	9.3	GDF5, EPHA7, ROR2, FGFR3, FGFR2, FGFR1
25	eIF2 Pathway36	9.3	GDF5, FGFR3, FGFR2, FGFR1, FGF8, FGF10
26	14-3-3 Induced Intracellular Signaling36	9.3	GDF5, EPHA7, ROR2, FGFR3, FGFR2, FGFR1
27	Ras Pathway36	9.3	GDF5, EPHA7, ROR2, FGFR3, FGFR2, FGFR1
28	Pancreatic Adenocarcinoma36	9.3	GDF5, EPHA7, ROR2, FGFR3, FGFR2, FGFR1
29	eNOS Signaling36	9.3	GDF5, EPHA7, ROR2, FGFR3, FGFR2, FGFR1
30	NFAT in Immune Response36	9.3	GDF5, EPHA7, ROR2, FGFR3, FGFR2, FGFR1
31	Estrogen Pathway36	9.3	GDF5, EPHA7, ROR2, FGFR3, FGFR2, FGFR1
32	GPCR Pathway36	9.3	GDF5, EPHA7, ROR2, FGFR3, FGFR2, FGFR1
33	Nanog in Mammalian ESC Pluripotency36	9.2	GDF5, EPHA7, WNT10B, ROR2, FGFR3, FGFR2
34	GSK3 Signaling36	9.2	GDF5, EPHA7, WNT10B, ROR2, FGFR3, FGFR2
35	JAK-STAT Pathway36	9.2	GDF5, EPHA7, ROR2, FGFR3, FGFR2, FGFR1
36	Activation of PKA through GPCR36	9.2	GDF5, EPHA7, ROR2, IHH, FGFR3, FGFR2
37	Breast Cancer Regulation by Stathmin136	9.2	GDF5, EPHA7, ROR2, FGFR3, FGFR2, FGFR1
38	Intracellular Calcium Signaling36	9.2	GDF5, EPHA7, ROR2, FGFR3, FGFR2, FGFR1
39	p38 Signaling36	9.1	GDF5, EPHA7, ROR2, IL11RA, FGFR3, FGFR2
40	Akt Signaling36	9.1	GDF5, EPHA7, ROR2, IL11RA, FGFR3, FGFR2
41	Rac1 Pathway36	9.0	GDF5, FGFR3, FGFR2, FGFR1, FGF8, FGF10
42	Pathways in cancer20	9.0	WNT9A, WNT10B, SHH, PTCH1, GLI3, FGFR3
43	Inhibition of Angiogenesis by TSP136	8.9	COL2A1, FBN2, FBN1, FRAS1, LAMA5
44	PTEN Pathway36	7.8	GDF5, COL2A1, FBN2, FBN1, FGFR3, FGFR2
45	Phospholipase-C Pathway36	7.8	GDF5, COL2A1, FBN2, FBN1, FGFR3, FGFR2
46	ILK Signaling36	7.4	LAMA5, GDF5, EPHA7, ROR2, COL2A1, FBN2
47	MAPK Signaling36	7.4	FBN2, COL2A1, ROR2, EPHA7, GDF5, FBN1
48	Rho Family GTPases36	7.4	FBN2, COL2A1, ROR2, EPHA7, GDF5, FBN1
49	ERK Signaling36	7.4	FBN2, COL2A1, ROR2, EPHA7, GDF5, FBN1
50	Molecular Mechanisms of Cancer36	7.2	FBN2, IHH, COL2A1, ROR2, EPHA7, GDF5

Compounds related to syndactyly according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	pd 16157042	10.1	FGFR3, FGFR2, FGFR1
2	su540232	10.1	FGFR3, FGFR2, FGFR1
3	cyclopamine32	10.1	IHH, PTCH1, NOG, SHH
4	su 540242	10.0	FGFR3, FGFR2, FGFR1
5	su 666842	10.0	FGFR3, FGFR2, FGFR1
6	pd 17307432 42	10.9	FGFR3, FGFR2, FGFR1
7	palifermin32 9 9	11.8	FGFR1, FGFR2, FGFR3
8	SU49849 9	10.7	FGFR2, FGFR1
9	heparan sulfate32 18	9.7	LAMA5, PVRL1, NOG, FBN1, FGFR2, FGFR1
10	tyrosine32	7.5	EPHA7, ROR2, PVRL1, EIF6, NOG, PTCH1

Cellular components related to syndactyly according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	basement membrane	GO:005604	7.9	COL2A1, SMOC1, FBN1, FREM2, FREM1, FREM3
2	extracellular space	GO:005615	7.8	GDF5, WNT10B, SOST, SHH, COL2A1, NOG
3	extracellular matrix	GO:031012	7.7	SFRP2, ZP2, SOST, SHH, IHH, FBN1
4	extracellular region	GO:005576	6.9	CRIM1, NOG, COL2A1, PVRL1, PVRL4, WNT9A

Biological processes related to syndactyly according to GeneDecks:

(show top 50)    (show all 85)

id	Name	GO ID	Score	Top Affiliating Genes
1	branching morphogenesis of a nerve	GO:048755	10.6	FGFR2, EPHA7, DLX2
2	negative regulation of alpha-beta T cell differentiation	GO:046639	10.6	SHH, IHH, GLI3
3	hindlimb morphogenesis	GO:035137	10.4	SALL1, HOXD10, GDF5, HOXD9
4	positive regulation of chondrocyte differentiation	GO:032332	10.4	GLI3, GDF5, HOXD11, IHH
5	epithelial cell proliferation involved in salivary gland morphogenesis	GO:060664	10.4	SHH, FGF10, FGFR2
6	proximal/distal pattern formation	GO:009954	10.3	HOXD9, LRP4, HOXD10, GLI3, HOXD11, TP63
7	hair follicle morphogenesis	GO:031069	10.3	FGFR2, TP63, SHH, FGF10
8	embryonic pattern specification	GO:009880	10.3	SHH, FGF10, IHH, FGFR2
9	embryonic digestive tract morphogenesis	GO:048557	10.3	FGFR2, FGF10, IHH, GLI3, SHH
10	positive regulation of alpha-beta T cell differentiation	GO:046638	10.3	SHH, GLI3, IHH
11	embryonic skeletal system development	GO:048706	10.3	DLX1, NOG, SHH, HOXD1
12	negative regulation of smoothened signaling pathway	GO:045879	10.3	KIF7, SALL1, PTCH1, GLI3
13	somite development	GO:061053	10.3	SHH, PTCH1, IHH, NOG
14	embryonic forelimb morphogenesis	GO:035115	10.2	ALX4, HOXD9, SHH, MSX2
15	dorsal/ventral pattern formation	GO:009953	10.2	PTCH1, HOXD11, LRP4, SHH, NOG
16	positive regulation of phospholipase activity	GO:010518	10.2	FGFR1, FGFR2, FGFR3
17	metanephros development	GO:001656	10.2	SHH, FGF10, FGF8, GLI3, HOXD11
18	limb bud formation	GO:060174	10.2	FGF10, SHH, COL2A1, GJA1, FGFR2
19	otic vesicle formation	GO:030916	10.2	FGF8, FGFR2, FGF10
20	patterning of blood vessels	GO:001569	10.2	SFRP2, FGF8, SHH, IHH
21	positive regulation of mesenchymal cell proliferation	GO:002053	10.2	FBXW4, FGFR2, IHH, TP63, FGFR1
22	anterior/posterior pattern specification	GO:009952	10.1	SHH, MSX2, GLI3, HOXD10, HOXD11, HOXD13
23	limb morphogenesis	GO:035108	10.1	PTCH1, EVX2, GLI3
24	outflow tract septum morphogenesis	GO:003148	10.1	FGF8, MSX2, FGFR2
25	embryonic hindlimb morphogenesis	GO:035116	10.1	MSX2, FGF8, ALX4, SHH
26	lung-associated mesenchyme development	GO:060484	10.1	FGFR1, FGFR2, SHH
27	forelimb morphogenesis	GO:035136	10.1	SALL1, HOXD10, GDF5
28	lung development	GO:030324	10.1	SHH, DHCR7, FGFR2, LAMA5, GLI3
29	cartilage development	GO:051216	10.1	COL2A1, FBXW4, IHH, DLX2, NOG, GDF5
30	embryonic skeletal system morphogenesis	GO:048704	10.0	HOXD10, GLI3, ALX4, HOXD9
31	branching involved in ureteric bud morphogenesis	GO:001658	10.0	FGF8, SHH, HOXD11, GLI3, LAMA5, SALL1
32	organ induction	GO:001759	10.0	HOXD11, FGFR1, FGF8, FGF10
33	negative regulation of canonical Wnt receptor signaling pathway	GO:090090	9.9	NOG, SFRP2, GLI3, LRP4, SHH, SOST
34	embryonic digit morphogenesis	GO:042733	9.9	LRP4, GLI3, HOXD12, SHH, SALL1, FBXW4
35	chondrocyte differentiation	GO:002062	9.9	FGFR3, COL2A1, FGFR1, WNT10B
36	odontogenesis of dentin-containing tooth	GO:042475	9.9	DLX1, LRP4, FGF10, GLI3, TP63, DLX2
37	branching involved in salivary gland morphogenesis	GO:060445	9.8	LAMA5, FGF8, FGFR1, FGFR2, SHH
38	cell-cell signaling	GO:007267	9.7	SFRP2, FGFR2, GJA1, SHH, WNT9A, GDF5
39	smoothened signaling pathway	GO:007224	9.6	IHH, SHH, PTCH1, GLI3
40	negative regulation of cell proliferation	GO:008285	9.4	GLI3, AZGP1, MSX2, FGF10, SFRP2, WNT9A
41	negative regulation of apoptotic process	GO:043066	9.3	IHH, GLI3, NOG, FGFR1, FGF10, COL2A1
42	positive regulation of osteoblast differentiation	GO:045669	INF	, GLI3, FBN2, MSX2, SFRP2
43	palate development	GO:060021	INF	COL2A1, GLI3, ALX4, SHH,
44	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	IHH, FGFR2, FGF10, SALL1, GLI3, HOXD10
45	positive regulation of epithelial cell proliferation	GO:050679	INF	NOG, , IHH, FGFR2, FGF10
46	skeletal system development	GO:001501	INF	HOXD12, COL2A1, , NOG, FGFR1, FGFR3
47	negative regulation of transcription from RNA polymerase II promoter	GO:000122	INF	DLX1, GLI3, PTCH1, , FGFR1, DLX2
48	embryonic limb morphogenesis	GO:030326	INF	FGFR1, TP63, HOXD10, FBXW4, PTCH1, SHH
49	positive regulation of canonical Wnt receptor signaling pathway	GO:090263	INF	FGFR2, FGF10, ROR2, , WNT10B, SFRP2
50	inner ear morphogenesis	GO:042472	INF	ROR2, COL2A1, , FGFR2, FGFR1

Molecular functions related to syndactyly according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	fibroblast growth factor-activated receptor activity	GO:005007	9.9	FGFR3, FGFR2, FGFR1
2	fibroblast growth factor binding	GO:017134	9.9	FGFR1, FGFR2, FGFR3
3	chromatin binding	GO:003682	9.6	DLX2, DLX1, TP63, HOXD13, HOXD10, GLI3
4	sequence-specific DNA binding	GO:043565	9.5	HOXD9, HOXD13, HOXD12, HOXD11, HOXD10, HOXD1
5	sequence-specific DNA binding transcription factor activity	GO:003700	INF	SALL1, , DLX2, DLX1, HOXD9, HOXD13