Aliases & Classifications for Synostosis

MalaCards integrated aliases for Synostosis:

Name: Synostosis 12 51 41 14

Classifications:



External Ids:

Disease Ontology 12 DOID:11971
MeSH 41 D013580
UMLS 69 C0039093

Summaries for Synostosis

Disease Ontology : 12 A dysostosis that results_in abnormal fusing of adjacent bones.

MalaCards based summary : Synostosis is related to humeroradial synostosis and spondylocarpotarsal synostosis syndrome. An important gene associated with Synostosis is HOXA11 (Homeobox A11), and among its related pathways/superpathways are PAK Pathway and Pathways in cancer. The drugs Tranexamic Acid and Antifibrinolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and bone marrow, and related phenotypes are growth/size/body region and craniofacial

Wikipedia : 72 Synostosis (plural: synostoses) is fusion of two bones. It can be normal in puberty, fusion of the... more...

Related Diseases for Synostosis

Diseases related to Synostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 200)
# Related Disease Score Top Affiliating Genes
1 humeroradial synostosis 33.5 FGFR2 NOG
2 spondylocarpotarsal synostosis syndrome 33.4 FLNB MYH3
3 radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome 33.3 HOXA11 MECOM
4 radioulnar synostosis 33.1 FGFR1 FGFR2 HOXA11 LRP4 MECOM
5 muenke syndrome 32.3 EFNB1 FGFR1 FGFR2 FGFR3 RAB23 TWIST1
6 isolated brachycephaly 31.7 FGFR3 TCF12 TWIST1
7 chromosome 2q35 duplication syndrome 31.6 FGFR2 FGFR3 GLI3 NOG
8 saethre-chotzen syndrome 31.6 FGFR1 FGFR2 FGFR3 MSX2 TWIST1
9 apert syndrome 31.3 FGFR1 FGFR2 FGFR3 GLI3 RAB23 TWIST1
10 isolated plagiocephaly 31.2 FGFR3 TCF12 TWIST1
11 plagiocephaly 30.7 FGFR1 FGFR2 FGFR3 TWIST1
12 achondroplasia 30.0 FGFR1 FGFR2 FGFR3
13 chiari malformation 29.6 FGFR3 LRP4
14 craniosynostosis 29.5 EFNB1 FGFR1 FGFR2 FGFR3 MSX2 NELL1
15 crouzon syndrome 29.4 FGFR1 FGFR2 FGFR3 MSX2
16 congenital radioulnar synostosis 12.3
17 radioulnar synostosis with amegakaryocytic thrombocytopenia 1 12.3
18 radioulnar synostosis-microcephaly-scoliosis syndrome 12.1
19 radioulnar synostosis with amegakaryocytic thrombocytopenia 2 12.1
20 radioulnar synostosis with microcephaly, short stature, scoliosis, and mental retardation 11.9
21 humeroradioulnar synostosis 11.9
22 lambdoid synostosis 11.9
23 coronal synostosis, syndactyly and jejunal atresia 11.9
24 tibio-fibular synostosis 11.9
25 humero-ulnar synostosis 11.9
26 radioulnar synostosis, radial ray abnormalities, and severe malformations in the male 11.9
27 radioulnar synostosis, unilateral, with developmental retardation and hypotonia 11.8
28 radio-ulnar synostosis type 1 11.8
29 radio-ulnar synostosis type 2 11.8
30 craniosynostosis-hydrocephalus-arnold-chiari malformation type i-radioulnar synostosis syndrome 11.8
31 humeroradial synostosis with craniofacial anomalies 11.7
32 cleft palate colobomata radial synostosis deafness 11.7
33 congenital heart disease radio ulnar synostosis mental retardation 11.7
34 synostosis of talus and calcaneus short stature 11.7
35 deafness-genital anomalies-metacarpal and metatarsal synostosis syndrome 11.7
36 humero-radial synostosis, unilateral 11.7
37 humero-radial synostosis, bilateral 11.7
38 humero-radio-ulnar synostosis, unilateral 11.7
39 humero-radio-ulnar synostosis, bilateral 11.7
40 radio-ulnar synostosis, unilateral 11.7
41 radio-ulnar synostosis, bilateral 11.7
42 humero-ulnar synostosis, unilateral 11.7
43 humero-ulnar synostosis, bilateral 11.7
44 antley-bixler syndrome without genital anomalies or disordered steroidogenesis 11.7
45 antley-bixler syndrome 11.6
46 mesomelic dysplasia, kantaputra type 11.5
47 synostoses, tarsal, carpal, and digital 11.4
48 jorgenson lenz syndrome 11.3
49 cardiospondylocarpofacial syndrome 11.2
50 ramer ladda syndrome 11.2

Graphical network of the top 20 diseases related to Synostosis:



Diseases related to Synostosis

Symptoms & Phenotypes for Synostosis

MGI Mouse Phenotypes related to Synostosis:

43 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.41 EFNB1 FGFR2 FGFR1 FGFR3 GLI3 FLNB
2 craniofacial MP:0005382 10.4 EFNB1 FGFR2 FGFR1 FGFR3 FLNB GSC
3 limbs/digits/tail MP:0005371 10.39 EFNB1 FGFR2 FGFR1 FGFR3 BHLHA9 FLNB
4 mortality/aging MP:0010768 10.39 EFNB1 FGFR2 FGFR1 GLI3 FLNB GSC
5 cellular MP:0005384 10.38 EFNB1 FGFR2 FGFR1 BHLHA9 FGFR3 GLI3
6 behavior/neurological MP:0005386 10.32 FGFR1 FGFR2 FGFR3 FLNB GSC LRP4
7 embryo MP:0005380 10.31 EFNB1 FGFR2 FGFR1 GLI3 GSC MECOM
8 cardiovascular system MP:0005385 10.27 FGFR1 FGFR2 GLI3 FLNB MECOM IFT122
9 digestive/alimentary MP:0005381 10.25 EFNB1 FGFR2 FGFR1 FGFR3 GLI3 GSC
10 nervous system MP:0003631 10.24 EFNB1 FGFR2 FGFR1 FGFR3 GLI3 FLNB
11 endocrine/exocrine gland MP:0005379 10.22 FGFR1 EFNB1 FGFR2 GLI3 LRP4 HOXA11
12 integument MP:0010771 10.22 EFNB1 FGFR2 FGFR1 FGFR3 GLI3 GSC
13 hearing/vestibular/ear MP:0005377 10.15 EFNB1 FGFR2 FGFR1 FGFR3 GLI3 GSC
14 reproductive system MP:0005389 9.96 EFNB1 FGFR2 FGFR1 FGFR3 GLI3 GDF5
15 muscle MP:0005369 9.95 FGFR1 FGFR2 GSC MECOM NOG MSX2
16 renal/urinary system MP:0005367 9.87 FGFR1 FGFR2 FGFR3 GLI3 LRP4 HOXA11
17 skeleton MP:0005390 9.86 EFNB1 FGFR2 FGFR1 FLNB GSC GDF5
18 respiratory system MP:0005388 9.85 EFNB1 FGFR2 FGFR3 GLI3 FLNB GSC
19 vision/eye MP:0005391 9.32 EFNB1 FGFR2 FGFR1 FGFR3 GLI3 IFT122

Drugs & Therapeutics for Synostosis

Drugs for Synostosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 4,Phase 3 1197-18-8 5526
2 Antifibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1
3 Coagulants Phase 4,Phase 3,Phase 2,Phase 1
4 Hemostatics Phase 4,Phase 3,Phase 2,Phase 1
5 Skullcap Nutraceutical Phase 4,Phase 1
6
Aminocaproic Acid Approved, Investigational Phase 2,Phase 1 60-32-2 564
7
Menthol Approved 2216-51-5 16666
8
Iron Approved 7439-89-6 23925
9 Analgesics
10 Peripheral Nervous System Agents
11
Bilirubin 635-65-4 5280352
12 Epoetin alfa 113427-24-0
13 Ferrous fumarate
14 Hematinics
15 Micronutrients
16 Trace Elements
17 Calcium, Dietary
18 Calamus Nutraceutical

Interventional clinical trials:

(show all 38)

# Name Status NCT ID Phase Drugs
1 The Efficacy and Population Pharmacokinetics of Tranexamic Acid for Craniosynostosis Surgery Active, not recruiting NCT02188576 Phase 4 high dose TXA;Low dose TXA
2 Tranexamic Acid for Craniofacial Surgery Terminated NCT00722436 Phase 4 Tranexamic acid;saline
3 Comparison of a Bone Product to Bone Dust in Ossification of Small Calvarial Defects. Withdrawn NCT01006148 Phase 4
4 Blood Loss and Transfusion Requirement in Infants Treated With Tranexamic Acid Unknown status NCT01094977 Phase 3 Tranexamic Acid;Tranexamic Acid;Saline Placebo
5 Efficacy of Amicar for Children Having Craniofacial Surgery Recruiting NCT02229968 Phase 2 Amicar (ε-aminocaproic acid);normal saline
6 Stem Cells and Tibial Fractures Completed NCT00632034 Phase 1
7 Amicar Pharmacokinetics of Children Having Craniofacial Surgery Completed NCT00912119 Phase 1 Epsilon-Aminocaproic Acid;Epsilon-Aminocaproic Acid;Epsilon-Aminocaproic Acid;Epsilon-Aminocaproic Acid
8 Mononucleotide Autologous Stem Cells and Demineralized Bone Matrix in the Treatment of Non Union/Delayed Fractures Unknown status NCT01435434
9 The Effect of Gender on the Consumption of Pain Medication in Infants Undergoing Craniosynostosis Repair or Untethering of Cord in ITU Unknown status NCT01996163
10 Treatment of Displaced Lateral Clavicle Fractures Using a Locking Compression Plate With Lateral Extension Completed NCT02256059
11 MRI for Non-invasive Evaluation of Brain Stress Completed NCT01898650
12 Evaluation of Effects of Clavicular Hook Plate on Subacromial Space Completed NCT01205763
13 Qualitative and Quantitative Study Which Aims to Determine the Specifics of the Announcement for the Diagnosis of Patients With Craniosynostosis and Their Parents to Better Support Them in Their Care Completed NCT02287805
14 Effect of Tranexamic Acid Based on Pharmacokinetics in Pediatric Patients Undergoing Craniosynostosis Surgery: Randomized Controlled Trial Completed NCT02180321 Tranexamic Acid;normal saline
15 Nautilus: Dynamic Craniotomy; New Surgical Technique and Preliminary Results Completed NCT01672619
16 Genetic Analysis of Craniosynostosis, Philadelphia Type Completed NCT00367796
17 Child and Infant Learning Project Completed NCT00077831
18 Treatment of Cranial Molding Deformities in Preterm Infants Completed NCT02366936
19 National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions Completed NCT01322165
20 Genetic Analysis of Fraser Syndrome and Fryns Syndrome Completed NCT00032877
21 Transtibial Amputation Outcomes Study Recruiting NCT01821976
22 Network Of Clinical Research Studies On Craniosynostosis, Skull Malformations With Premature Fusion Of Skull Bones Recruiting NCT03025763
23 Cancer in Inherited Bone Marrow Failure Syndromes Recruiting NCT00027274
24 Comparison of the Rate of Preoperative Haemoglobin After Administration of Epoetin Alpha Associated With an Oral Medical Supplementation Versus Intravenous Before Surgery of Craniosynostosis at the Child Recruiting NCT03231085 Ferrous fumarate
25 Optic Nerve Sheath Diameter in Craniosynostosis Recruiting NCT03131245
26 Comparison of Scar Formation in Syndactyly Release Surgery With Full Thickness Skin Graft Versus Skin Graft Substitute Recruiting NCT03107546
27 Treatment of Proximal Interphalangeal Joint Injuries. Clinical Efficiency of Syndactyly Treatment and Digital Compression Recruiting NCT02548260
28 Irradiated Blood Versus Non Irradiated Blood Transfusions in Craniosynostosis Repair Recruiting NCT02483702
29 Pathogenetic Basis of Aortopathy and Aortic Valve Disease Recruiting NCT03440697
30 Bohring-Opitz Syndrome and ASXL Registry Recruiting NCT03303716
31 Clinical Study of Muenke Syndrome (FGFR3-Related Craniosynostosis) Recruiting NCT00106977
32 Syndactyly Versus Closed Reduction in 5th Metacarpal Neck Fracture Active, not recruiting NCT03434587
33 Syndactyly Repair: Comparison of Skin Graft and No Skin Graft Techniques Active, not recruiting NCT01416090
34 Osteogenic Profiling of Tissue From Children With Craniosynostosis Active, not recruiting NCT00773643
35 Anterior Odontoid Screw Osteosynthesis in Treatment of Type 2 Odontoid Fracture Not yet recruiting NCT03355703
36 Cranial Cup Use for the Prevention of Positional Head Shape Deformity in the NICU Terminated NCT01218087
37 Endoscopic Treatment for Isolated, Single Suture Craniosynostosis Withdrawn NCT00769847
38 Hanger Helmet Study Withdrawn NCT02561728

Search NIH Clinical Center for Synostosis

Cochrane evidence based reviews: synostosis

Genetic Tests for Synostosis

Anatomical Context for Synostosis

MalaCards organs/tissues related to Synostosis:

38
Bone, Skin, Bone Marrow, Brain, Thyroid, Eye, Testes

Publications for Synostosis

Articles related to Synostosis:

(show top 50) (show all 699)
# Title Authors Year
1
Length of synostosis and segmented intracranial volume correlate with age in patients with non-syndromic sagittal synostosis. ( 29067505 )
2018
2
Minimally Invasive, Spring-Assisted Correction of Sagittal Suture Synostosis: Technique, Outcome, and Complications in 83 Cases. ( 29036024 )
2018
3
A MECOM variant in an African American child with radioulnar synostosis and thrombocytopenia. ( 29200407 )
2018
4
Isolated Intraorbital Frontosphenoidal Synostosis. ( 29068968 )
2018
5
Adult Chiari Type 1 Malformation with Holocord Syringomyelia Associated with Sagittal Synostosis. ( 29354335 )
2018
6
Surgical Treatment of Unicoronal Synostosis: A Simplified Technique without Orbital Osteotomy. ( 29261518 )
2018
7
Defining and Correcting Asymmetry in Isolated Unilateral Frontosphenoidal Synostosis: Differences in Orbital Shape, Facial Scoliosis, and Skullbase Twist Compared to Unilateral Coronal Synostosis. ( 29065043 )
2018
8
Distal tibiofibular synostosis following non-operative treatment of ankle fractures. ( 29315039 )
2018
9
Three-dimensional analysis of deformities of the radius and ulna in congenital proximal radioulnar synostosis. ( 29402171 )
2018
10
Discussion: Minimally Invasive, Spring-Assisted Correction of Sagittal Suture Synostosis: Technique, Outcome, and Complications in 83 Cases. ( 29369994 )
2018
11
Spring-Mediated Cranioplasty in Sagittal Synostosis: Does Age at Placement Affect Expansion? ( 29381616 )
2018
12
Non-syndromic bilateral ulnar aplasia with humero-radial synostosis and oligo-ectro-dactyly. ( 29427337 )
2018
13
Cranioplasty without Periosteal Dissection Reduces Blood Loss in Pi-Plasty Surgery for Sagittal Synostosis. ( 28693016 )
2017
14
Treated Unilateral Lambdoid Synostosis Using Cranium Distraction Osteogenesis With Z-shaped Osteotomy. ( 28059851 )
2017
15
KienbAPck Disease in a Patient with Congenital Synostosis of the Lunate and the Triquetrum: A Case Report. ( 29244670 )
2017
16
A 590 kb deletion caused by non-allelic homologous recombination between two LINE-1 elements in a patient with mesomelia-synostosis syndrome. ( 28328141 )
2017
17
The Management of Trigonoscaphocephaly as a Result of Combined Metopic and Sagittal Synostosis. ( 28538575 )
2017
18
Twenty-Year Review of a Single Surgeon's Experience Using a Unique Surgical Technique to Correct Lambdoidal Synostosis. ( 28962092 )
2017
19
Squamosal Suture Synostosis: Incidence, Associations, and Implications for Treatment. ( 28538065 )
2017
20
Bilateral capitato-hamato-trapezoidal synostosis. ( 28713069 )
2017
21
The Dorsoulnar Artery Perforator Adipofascial Flap in the Treatment of Distal Radioulnar Synostosis. ( 28811948 )
2017
22
Scaphoid Fracture in a Patient with a Scaphotrapezial Synostosis: A Case Report and Literature Review. ( 28197353 )
2017
23
The use of indomethacin in the prevention of postoperative radioulnar synostosis after distal biceps repair. ( 28104092 )
2017
24
Delayed Presentation of Isolated Sagittal Synostosis With Raised Intracranial Pressure and Secondary Chiari Malformation With Cervical Syringomyelia. ( 28582306 )
2017
25
Temporal Deformity Objectively Measured Before and After Surgery for Metopic Synostosis: Retrusion Rather than Hollowing. ( 28885443 )
2017
26
The Degree of Surgical Frontal Volume Correction in Metopic Synostosis Determines Long-Term Outcomes. ( 28358760 )
2017
27
The value of three-dimensional photogrammetry in isolated sagittal synostosis: Impact of age and surgical technique on intracranial volume and cephalic indexa98a retrospective cohort study. ( 29066040 )
2017
28
Post-Surgical Relapse in Metopic Synostosis and Limitations of the Interfrontal Angle as an Outcome Measure. ( 28665858 )
2017
29
Is Postoperative Intensive Care Unit Care Necessary following Cranial Vault Remodeling for Sagittal Synostosis? ( 29176416 )
2017
30
Comparing Outcomes and Cost of 3 Surgical Treatments for Sagittal Synostosis: A Retrospective Study Including Procedure-Related Cost Analysis. ( 28449032 )
2017
31
Proximal tibiofibular synostosis. ( 29125821 )
2017
32
Squamous Suture Synostosis: A Review With Emphasis on Cranial Morphology and Involvement of Other Cranial Sutures. ( 27831981 )
2017
33
A case of failure to correct humerus-radius synostosis and thumb hypoplasia. ( 28823203 )
2017
34
Transtibial Amputation Outcomes Study (TAOS): Comparing Transtibial Amputation With and Without a Tibiofibular Synostosis (Ertl) Procedure. ( 28323804 )
2017
35
Effect of Preoperative Molding Helmet in Patients With Sagittal Synostosis. ( 28549045 )
2017
36
Pathological fracture in a patient with an untreated congenital metacarpal synostosis. ( 28193122 )
2017
37
A postnatal role for embryonic myosin revealed by MYH3 mutations that alter TGFI^ signaling and cause autosomal dominant spondylocarpotarsal synostosis. ( 28205584 )
2017
38
Multidirectional Cranial Distraction Osteogenesis with Simplified Modifications for Treating Sagittal Synostosis. ( 29184744 )
2017
39
Congenital radioulnar synostosis. ( 28828125 )
2017
40
Circumferential Adipofascial Graft for Prevention of Recurrence of Posttraumatic Radioulnar Synostosis. ( 29107381 )
2017
41
Spondylocarpotarsal synostosis syndrome. A rare case of short stature and congenital scoliosis. ( 29263747 )
2017
42
Filamin B Loss-of-Function Mutation in Dimerization Domain Causes Autosomal-Recessive Spondylocarpotarsal Synostosis Syndrome with Rib Anomalies. ( 28145000 )
2017
43
Update on Treatment of Sagittal Synostosis: What Can We Learn From the 16th Congress of the International Society of Craniofacial Surgery? ( 28468130 )
2017
44
Cerebrospinal fluid collections in sagittal suture synostosis. ( 26767840 )
2016
45
Quantifying Craniometric Change Early After Fronto-Orbital Advancement in Metopic Synostosis. ( 27513770 )
2016
46
Surgical Treatment of Posttraumatic Radioulnar Synostosis. ( 26977328 )
2016
47
Synostosis of proximal phalangeal bases for loss of distal metacarpal. ( 27904227 )
2016
48
Capitate-trapezoid synostosis: Analysis of an early bronze age case and review of the literature. ( 27813627 )
2016
49
The Significance of Squamosal Suture Synostosis. ( 27438438 )
2016
50
Protein-altering MYH3 variants are associated with a spectrum of phenotypes extending to spondylocarpotarsal synostosis syndrome. ( 27381093 )
2016

Variations for Synostosis

Expression for Synostosis

Search GEO for disease gene expression data for Synostosis.

Pathways for Synostosis

GO Terms for Synostosis

Biological processes related to Synostosis according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.98 FGFR1 GLI3 HOXA11 NELL1
2 multicellular organism development GO:0007275 9.97 BHLHA9 EFNB1 FLNB GSC HOXA11 IFT122
3 skeletal system development GO:0001501 9.93 FGFR1 FGFR3 HOXA11 NOG
4 in utero embryonic development GO:0001701 9.92 FGFR1 FGFR2 GLI3 NOG TWIST1
5 osteoblast differentiation GO:0001649 9.9 MSX2 NOG TWIST1
6 phosphatidylinositol phosphorylation GO:0046854 9.89 FGFR1 FGFR2 FGFR3
7 anterior/posterior pattern specification GO:0009952 9.89 GLI3 HOXA11 MSX2
8 lung development GO:0030324 9.89 FGFR1 FGFR2 GLI3
9 positive regulation of MAPK cascade GO:0043410 9.88 FGFR1 FGFR2 FGFR3
10 BMP signaling pathway GO:0030509 9.88 LRP4 MSX2 NOG
11 positive regulation of neuron differentiation GO:0045666 9.88 FGFR1 GDF5 TCF12
12 fibroblast growth factor receptor signaling pathway GO:0008543 9.88 FGFR1 FGFR2 FGFR3
13 neural tube closure GO:0001843 9.87 IFT122 NOG TWIST1
14 muscle organ development GO:0007517 9.87 FLNB MYH3 TCF12 TWIST1
15 cartilage development GO:0051216 9.86 GDF5 MSX2 NOG
16 negative regulation of cell differentiation GO:0045596 9.85 GLI3 NOG TWIST1
17 negative regulation of epithelial cell proliferation GO:0050680 9.84 FGFR2 GDF5 IFT122
18 positive regulation of epithelial cell proliferation GO:0050679 9.84 FGFR2 NOG TWIST1
19 wound healing GO:0042060 9.84 FGFR2 GLI3 MSX2 NOG
20 positive regulation of osteoblast differentiation GO:0045669 9.83 GLI3 MSX2 NELL1
21 bone development GO:0060348 9.83 FGFR2 HOXA11 TWIST1
22 embryonic skeletal system morphogenesis GO:0048704 9.81 GLI3 GSC TWIST1
23 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.81 FGFR1 FGFR2 FGFR3
24 ureteric bud development GO:0001657 9.8 FGFR1 FGFR2 NOG
25 chondrocyte differentiation GO:0002062 9.79 FGFR1 FGFR3 GDF5
26 odontogenesis GO:0042476 9.77 FGFR2 MSX2 TWIST1
27 bone morphogenesis GO:0060349 9.76 FGFR2 FGFR3 MSX2
28 anatomical structure formation involved in morphogenesis GO:0048646 9.72 GLI3 NOG
29 endocardial cushion morphogenesis GO:0003203 9.72 NOG TWIST1
30 anatomical structure development GO:0048856 9.72 GLI3 LRP4
31 proximal/distal pattern formation GO:0009954 9.72 GLI3 HOXA11 LRP4
32 limb development GO:0060173 9.71 GLI3 IFT122 LRP4 NOG
33 hindlimb morphogenesis GO:0035137 9.7 GDF5 TWIST1
34 organ induction GO:0001759 9.69 FGFR1 HOXA11
35 branching involved in salivary gland morphogenesis GO:0060445 9.69 FGFR1 FGFR2
36 embryonic skeletal joint morphogenesis GO:0060272 9.69 HOXA11 NOG
37 positive regulation of chondrocyte differentiation GO:0032332 9.69 GDF5 GLI3 HOXA11
38 membranous septum morphogenesis GO:0003149 9.68 FGFR2 NOG
39 outer ear morphogenesis GO:0042473 9.68 FGFR1 TWIST1
40 lung-associated mesenchyme development GO:0060484 9.67 FGFR1 FGFR2
41 middle ear morphogenesis GO:0042474 9.67 FGFR1 GSC NOG
42 smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:0060831 9.66 GLI3 IFT122
43 BMP signaling pathway involved in heart development GO:0061312 9.65 MSX2 NOG
44 dorsal/ventral pattern formation GO:0009953 9.65 GLI3 HOXA11 IFT122 LRP4 NOG
45 cranial suture morphogenesis GO:0060363 9.64 MSX2 TWIST1
46 mesenchymal cell differentiation GO:0048762 9.63 FGFR1 FGFR2 NOG
47 embryonic forelimb morphogenesis GO:0035115 9.62 HOXA11 IFT122 MSX2 TWIST1
48 frontal suture morphogenesis GO:0060364 9.61 GLI3 MSX2
49 orbitofrontal cortex development GO:0021769 9.61 FGFR1 FGFR2
50 positive regulation of phospholipase activity GO:0010518 9.61 FGFR1 FGFR2 FGFR3

Molecular functions related to Synostosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.91 FGFR1 FGFR2 LRP4 NOG TCF12 TWIST1
2 nucleotide binding GO:0000166 9.72 FGFR1 FGFR2 FGFR3 MYH3 RAB23
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.63 FGFR1 FGFR2 FGFR3
4 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.54 FGFR1 FGFR2 FGFR3
5 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.43 FGFR1 FGFR2 FGFR3
6 1-phosphatidylinositol-3-kinase activity GO:0016303 9.33 FGFR1 FGFR2 FGFR3
7 fibroblast growth factor binding GO:0017134 9.13 FGFR1 FGFR2 FGFR3
8 fibroblast growth factor-activated receptor activity GO:0005007 8.8 FGFR1 FGFR2 FGFR3
9 protein binding GO:0005515 10.33 BHLHA9 EFNB1 FGFR1 FGFR2 FGFR3 FLNB

Sources for Synostosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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