Summaries for Synostosis

About this section


Wikipedia:65 Synostosis means fusion of two bones, it can be normal in puberty, fusion of the epiphysis, or abnormal.... more...

MalaCards based summary: Synostosis is related to radioulnar synostosis and craniosynostosis. An important gene associated with Synostosis is HOXA11 (homeobox A11), and among its related pathways are Endochondral Ossification and Signaling by FGFR3 mutants. The compounds pazopanib and regorafenib have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and brain, and related mouse phenotypes are renal/urinary system and no phenotypic analysis.

Disease Ontology:10 A dysostosis that results in abnormal fusing of adjacent bones.

Aliases & Classifications for Synostosis

About this section
Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 35MeSH, 62UMLS
See all sources

Synostosis, Aliases & Descriptions:

Name: Synostosis 10 12 45


External Ids:

Disease Ontology10 DOID:11971
MeSH35 D013580

Related Diseases for Synostosis

About this section

Diseases related to Synostosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 316)
idRelated DiseaseScoreTop Affiliating Genes
1radioulnar synostosis31.3HOXA11
2craniosynostosis30.6TWIST1, FGFR2, FGFR1, FGFR3
3antley-bixler syndrome30.5FGFR2
4muenke syndrome30.3FGFR3, FGFR1, FGFR2, TWIST1
5strabismus30.2FGFR2, FGFR3
6syndactyly30.2FGFR3, FGFR2
7apert syndrome30.1FGFR2, FGFR1, FGFR3
8achondroplasia30.1FGFR2, FGFR3
9pfeiffer syndrome30.1FGFR1, FGFR2
10crouzon syndrome30.1FGFR3, FGFR1, FGFR2
11ladd syndrome30.0FGFR2, FGFR3
12jackson-weiss syndrome29.9FGFR2, FGFR1, FGFR3
13saethre-chotzen syndrome29.9TWIST1, FGFR2, FGFR1, FGFR3
14osteoglophonic dysplasia29.8FGFR1
15osteochondroma29.8FGFR3
16acrocephalosyndactylia29.6TWIST1, FGFR2, FGFR1, FGFR3
17lambdoid synostosis10.6
18spondylocarpotarsal synostosis syndrome10.6
19congenital radio-ulnar synostosis10.5
20plagiocephaly10.5
21humeroradial synostosis10.4
22radioulnar synostosis with microcephaly, short stature, scoliosis, and mental retardation10.4
23ramer ladda syndrome10.3
24mesomelic dysplasia, kantaputra type10.3
25radioulnar synostosis with amegakaryocytic thrombocytopenia10.3
26symphalangism, proximal10.3
27humeroradioulnar synostosis10.3
28nievergelt syndrome10.3
29radioulnar synostosis retinal pigment abnormalities10.3
30microcephaly10.2
31ascher's syndrome10.2
32roberts syndrome10.2
33ivic syndrome10.2
34cervicitis10.2
35acropectorovertebral dysplasia10.2
36antley-bixler syndrome with genital anomalies and disordered steroidogenesis10.2
37williams-beuren syndrome10.2
38mesomelia-synostoses syndrome10.2
39cenani-lenz syndactyly syndrome10.2
40microphthalmia with limb anomalies10.2
41tarsal-carpal coalition syndrome10.2
42otopalatodigital syndrome, type i10.2
43calcaneonavicular coalition10.2
44intracranial hypertension10.2
45brachydactyly mononen type10.2
46coronal synostosis, syndactyly and jejunal atresia10.2
47radio-ulnar synostosis type 110.2
48radio-ulnar synostosis type 210.2
49craniosynostosis - hydrocephalus - arnold-chiari malformation type i - radioulnar synostosis10.2
50acrofacial dysostosis 1, nager type10.1

Graphical network of the top 20 diseases related to Synostosis:



Diseases related to synostosis

Symptoms for Synostosis

About this section

Drugs & Therapeutics for Synostosis

About this section

Drug clinical trials:

Search ClinicalTrials for Synostosis

Search NIH Clinical Center for Synostosis

Genetic Tests for Synostosis

About this section

Anatomical Context for Synostosis

About this section

MalaCards organs/tissues related to Synostosis:

33
Bone, Bone marrow, Brain, Thyroid, Eye, Testes

Animal Models for Synostosis or affiliated genes

About this section

Publications for Synostosis

About this section

Articles related to Synostosis:

(show top 50)    (show all 586)
idTitleAuthorsYear
1
One-stage rotational osteotomy for congenital radioulnar synostosis. (25827142)
2015
2
Correction of hypotelorism in isolated metopic synostosis. (23848421)
2014
3
Surgical correction for unilateral lambdoid synostosis: a systematic review. (24978452)
2014
4
Isolated frontosphenoidal synostosis: a rare cause of synostotic frontal plagiocephaly. (24606403)
2014
5
Proximal radial diaphyseal segment resection for posttraumatic proximal radioulnar synostosis: a prospective study of 15 cases. (24768222)
2014
6
Post-traumatic humero-ulnar synostosis. (24732097)
2014
7
Improving ophthalmic outcomes in children with unilateral coronal synostosis by treatment with endoscopic strip craniectomy and helmet therapy rather than fronto-orbital advancement. (23791406)
2013
8
Early frontofacial symmetry after correction of unilateral coronal synostosis: frontoorbital advancement vs endoscopic strip craniectomy and helmet therapy. (23851767)
2013
9
Modified osteotomy (Kanaya's procedure) for congenital proximal radioulnar synostosis with posterior dislocation of radial head. (23821677)
2013
10
Bilateral coronal and sagittal synostosis in X-linked hypophosphatemic rickets: a case report. (23466123)
2013
11
Rapid re-synostosis following suturectomy in pediatric mice is age and location dependent. (23201269)
2013
12
Magnetic resonance imaging in isolated sagittal synostosis. (22801186)
2012
13
A family with radio-ulnar synostosis, scoliosis, and thick vermilion of lips: a novel syndrome or variant of GiuffrA"-Tsukahara syndrome? (22786695)
2012
14
Preoperative and postoperative developmental attainment in patients with sagittal synostosis: 5-year follow-up. (21284455)
2011
15
Proximal tibiofibular synostosis as a possible cause of a pseudoradicular syndrome: a case report. (21222100)
2011
16
Tibia vara deformity after below knee amputation and synostosis formation in children. (19352235)
2009
17
Three-dimensional motion analysis of compensatory movements in patients with radioulnar synostosis performing activities of daily living. (19499298)
2009
18
Two cases of feline ectromelia: autopodium ectromelia associated with humero-ulnar synostosis and zeugopodium ectromelia. (19560386)
2009
19
Increased frequency of left-handedness in patients with unilateral coronal synostosis. (19642752)
2009
20
Craniosynostosis, hydrocephalus, Chiari I malformation and radioulnar synostosis: probably a new syndrome. (19022412)
2009
21
Bilateral lambdoid and sagittal synostosis (BLSS): a unique craniosynostosis syndrome or predictable craniofacial phenotype? (19396832)
2009
22
Proximal radio-ulnar synostosis and nonunion after olecranon fracture tension-band wiring: a case report. (19393921)
2009
23
Unilateral radio-ulnar synostosis and idic-Y chromosome. (19239087)
2008
24
Humero-radial synostosis, microcephaly, short corpus callosum, and abnormal genitalia in sibs. (18553517)
2008
25
Zygomaticotemporal synostosis: a rare cause of progressive facial asymmetry. (17214532)
2007
26
Sagittal synostosis in X-linked hypophosphatemic rickets and related diseases. (17551721)
2007
27
Craniofacial anomalies, humero-radial synostosis, rhizomelic limb shortness: previously unrecognized autosomal recessive syndrome. (17304553)
2007
28
Frontosphenoidal synostosis: a rare cause of unilateral anterior plagiocephaly. (17891404)
2007
29
Heterotopic ossification causing proximal radioulnar synostosis after insertion of a radial head prosthesis. (16753242)
2006
30
Asymmetrical tetraphocomelia with radiohumeral synostosis. (16885632)
2006
31
Undiagnosed obstructive sleep apnea syndrome in children with syndromal craniofacial synostosis. (15213550)
2004
32
Bilateral aplasia of the thumb, proximal radioulnar synostosis and unilateral synostosis of metacarpals 4 and 5. (15083702)
2004
33
Hybrid of distraction osteogenesis unilateral frontal distraction and supraorbital reshaping in correction of unilateral coronal synostosis. (15547381)
2004
34
Posttraumatic distal radioulnar synostosis and distal radial epiphyseal arrest. (11881314)
2002
35
Clinical outcome of the modified pi-plasty procedure for sagittal synostosis. (11358093)
2001
36
The faith of a coronal suture grafted onto midline synostosis inducing dura and deprived from tensile stress. (11522177)
2001
37
Management of radioulnar synostosis with mobilization, anconeus interposition, and a forearm rotation assist splint. (10633900)
1999
38
The Antley-Bixler syndrome. A new case without radiohumeral synostosis. (9664207)
1998
39
Preoperative morphology and development in sagittal synostosis. (9672839)
1998
40
Surgical management of sagittal synostosis: a comparative analysis of strip craniectomy and calvarial vault remodeling. (9548524)
1997
41
Osteoblast-directed osteoclast metabolism from patients with premature coronal synostosis. (9145118)
1997
42
Long-term studies of metopic synostosis: frequency of cognitive impairment and behavioral disturbances. (8559809)
1996
43
Stability of fronto-orbital advancement in nonsyndromic bilateral coronal synostosis: a quantitative three-dimensional computed tomographic study. (8700973)
1996
44
Occipital plagiocephaly: deformation or lambdoid synostosis? II. A unifying theory regarding pathogenesis. (8841076)
1996
45
Outcome analysis of 85 patients undergoing the pi procedure for correction of sagittal synostosis. (8683282)
1996
46
Lambdoid synostosis. (7813157)
1994
47
Radio-ulnar synostosis following external fixation. (8294821)
1993
48
Treatment of posttraumatic radioulnar synostosis with excision and low-dose radiation. (8349985)
1993
49
Radiohumeral synostosis, femoral bowing, other skeletal anomalies and anal atresia, a variant example of Antley-Bixler syndrome? (8267929)
1993
50
A Case of Enlarged Parietal Foramina associated with Metropism and Irregular Synostosis of the Coronal Suture. (17104407)
1932

Variations for Synostosis

About this section

Expression for genes affiliated with Synostosis

About this section

Search GEO for disease gene expression data for Synostosis.

Pathways for genes affiliated with Synostosis

About this section

Pathways related to Synostosis according to GeneCards/GeneDecks:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4FGFR1, FGFR3
2
Show member pathways
9.4FGFR3, FGFR1
39.3FGFR1, FGFR2
4
Show member pathways
8.8FGFR3, FGFR1, FGFR2
5
Show member pathways
8.8FGFR3, FGFR1, FGFR2
68.8FGFR3, FGFR1, FGFR2
7
Show member pathways
8.8FGFR3, FGFR1, FGFR2
8
Show member pathways
8.8FGFR3, FGFR1, FGFR2
9
Show member pathways
8.8FGFR3, FGFR1, FGFR2
10
Show member pathways
8.8FGFR3, FGFR1, FGFR2
11
Show member pathways
8.8FGFR3, FGFR1, FGFR2
12
Show member pathways
8.8FGFR3, FGFR1, FGFR2
13
Show member pathways
8.8FGFR3, FGFR1, FGFR2
14
Show member pathways
8.8FGFR3, FGFR1, FGFR2
158.8FGFR3, FGFR1, FGFR2
16
Show member pathways
Signaling Pathways in Glioblastoma38
8.8FGFR3, FGFR1, FGFR2
17
Show member pathways
8.8FGFR3, FGFR1, FGFR2
18
Show member pathways
8.8FGFR3, FGFR1, FGFR2
198.8FGFR3, FGFR1, FGFR2
20
Show member pathways
8.8FGFR3, FGFR1, FGFR2
218.8FGFR3, FGFR1, FGFR2
22
Show member pathways
8.8FGFR3, FGFR1, FGFR2
23
Show member pathways
8.8FGFR3, FGFR1, FGFR2
24
Show member pathways
8.8FGFR3, FGFR1, FGFR2
25
Show member pathways
8.8FGFR3, FGFR1, FGFR2
26
Show member pathways
8.8FGFR2, FGFR1, FGFR3
27
Show member pathways
8.8FGFR2, FGFR1, FGFR3
28
Show member pathways
8.8FGFR2, FGFR1, FGFR3
29
Show member pathways
8.8FGFR2, FGFR1, FGFR3
30
Show member pathways
8.8FGFR2, FGFR1, FGFR3
31
Show member pathways
8.8FGFR2, FGFR1, FGFR3
328.8FGFR2, FGFR1, FGFR3
33
Show member pathways
8.8FGFR2, FGFR1, FGFR3
34
Show member pathways
8.8FGFR2, FGFR1, FGFR3
358.8FGFR2, FGFR1, FGFR3
36
Show member pathways
8.8FGFR2, FGFR1, FGFR3
37
Show member pathways
8.8FGFR2, FGFR1, FGFR3
38
Show member pathways
8.8FGFR2, FGFR1, FGFR3
398.7FGFR1, TWIST1, FLNB
40
Show member pathways
MAPK signaling pathway38
8.4FGFR3, FGFR1, FGFR2, FLNB
41
Show member pathways
8.4FLNB, FGFR2, FGFR1, FGFR3
42
Show member pathways
8.4FGFR3, FGFR1, FGFR2, FLNB
438.0FGFR3, FGFR1, FGFR2, TWIST1

Compounds for genes affiliated with Synostosis

About this section

Compounds related to Synostosis according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1pazopanib51 1310.7FGFR1, FGFR3
2regorafenib51 1310.6FGFR2, FGFR1
3chondroitin sulfate45 2610.5FGFR2, FGFR1
4thalidomide45 51 61 1312.5FGFR2, FGFR3
5suramin45 30 1311.4FGFR1, FGFR2
6bromodeoxyuridine459.3FGFR1, FGFR2
7sulfate45 2610.2FGFR3, FGFR2
8su 5402619.2FGFR3, FGFR2, FGFR1
9pd 161570619.2FGFR2, FGFR1, FGFR3
10fiin 1 hydrochloride619.2FGFR2, FGFR1, FGFR3
11su5402459.2FGFR2, FGFR1, FGFR3
12pd 17307445 6110.1FGFR3, FGFR1, FGFR2
13progesterone45 30 61 26 1313.1FGFR1, FGFR2, HOXA11
14palifermin45 1310.1FGFR2, FGFR1, FGFR3
15ponatinib51 1310.1FGFR3, FGFR1, FGFR2
16phenylalanine459.1FGFR3, FGFR1, FGFR2
17phosphotyrosine459.1FGFR3, FGFR1, FGFR2
18lysine459.1FGFR3, FGFR1, FGFR2
19oligonucleotide459.0FGFR2, FGFR1, FGFR3
20vegf458.9FGFR3, FGFR1, FGFR2
21threonine458.8FGFR2, FGFR1, FGFR3
22paclitaxel45 51 1310.8TWIST1, FGFR2, FGFR1
23glutamate458.5FGFR3, FGFR1, FGFR2
24tyrosine458.2TWIST1, FGFR2, FGFR1, FGFR3

GO Terms for genes affiliated with Synostosis

About this section

Cellular components related to Synostosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1focal adhesionGO:00059259.5FGFR3, FLNB
2cell cortexGO:00059389.3FLNB, FGFR2
3cytoplasmic membrane-bounded vesicleGO:00160238.8FGFR2, FGFR1, FGFR3
4nucleusGO:00056347.3FGFR3, HOXA11, TWIST1, FGFR2, FGFR1

Biological processes related to Synostosis according to GeneCards/GeneDecks:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1organ inductionGO:00017599.9FGFR1, HOXA11
2positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:00900809.9FGFR1, FGFR3
3embryonic limb morphogenesisGO:00303269.8FGFR1, HOXA11
4fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:00356079.8FGFR1, FGFR2
5ventricular zone neuroblast divisionGO:00218479.8FGFR1, FGFR2
6mesenchymal cell differentiationGO:00487629.8FGFR2, FGFR1
7lens fiber cell developmentGO:00703079.7FGFR2, FGFR3
8negative regulation of mitosisGO:00458399.7FGFR2, FGFR3
9lung-associated mesenchyme developmentGO:00604849.7FGFR1, FGFR2
10branching involved in salivary gland morphogenesisGO:00604459.7FGFR1, FGFR2
11chondrocyte differentiationGO:00020629.7FGFR1, FGFR3
12positive regulation of cardiac muscle cell proliferationGO:00600459.7FGFR1, FGFR2
13bone morphogenesisGO:00603499.7FGFR2, FGFR3
14skeletal system morphogenesisGO:00487059.7FGFR2, FGFR1
15positive regulation of cell cycleGO:00457879.7FGFR1, FGFR2
16midbrain developmentGO:00309019.6FGFR2, FGFR1
17positive regulation of mesenchymal cell proliferationGO:00020539.6FGFR1, FGFR2
18ureteric bud developmentGO:00016579.6FGFR1, FGFR2
19embryonic forelimb morphogenesisGO:00351159.5HOXA11, TWIST1
20outer ear morphogenesisGO:00424739.5TWIST1, FGFR1
21negative regulation of epithelial cell proliferationGO:00506809.5FGFR3, FGFR2
22positive regulation of canonical Wnt signaling pathwayGO:00902639.5FGFR2, FGFR3
23embryonic digit morphogenesisGO:00427339.4TWIST1, HOXA11
24inner ear morphogenesisGO:00424729.4FGFR1, FGFR2
25skeletal system developmentGO:00015019.4FGFR3, FGFR1, HOXA11
26MAPK cascadeGO:00001659.4FGFR3, FGFR1
27embryonic cranial skeleton morphogenesisGO:00487019.4TWIST1, FGFR2
28odontogenesisGO:00424769.3FGFR2, TWIST1
29positive regulation of phospholipase activityGO:00105189.3FGFR3, FGFR1, FGFR2
30positive regulation of MAPK cascadeGO:00434109.2FGFR2, FGFR1, FGFR3
31peptidyl-tyrosine phosphorylationGO:00181089.2FGFR3, FGFR1, FGFR2
32phosphatidylinositol-mediated signalingGO:00480159.2FGFR3, FGFR1, FGFR2
33insulin receptor signaling pathwayGO:00082869.2FGFR3, FGFR1, FGFR2
34protein autophosphorylationGO:00467779.2FGFR2, FGFR1, FGFR3
35fibroblast growth factor receptor signaling pathwayGO:00085439.2FGFR3, FGFR1, FGFR2
36Fc-epsilon receptor signaling pathwayGO:00380959.2FGFR2, FGFR1, FGFR3
37epidermal growth factor receptor signaling pathwayGO:00071739.2FGFR2, FGFR1, FGFR3
38neurotrophin TRK receptor signaling pathwayGO:00480119.2FGFR3, FGFR1, FGFR2
39neuron migrationGO:00017649.1FGFR1, TWIST1
40positive regulation of epithelial cell proliferationGO:00506799.1FGFR2, TWIST1
41positive regulation of ERK1 and ERK2 cascadeGO:00703749.0FGFR3, FGFR2
42positive regulation of cell proliferationGO:00082849.0FGFR2, FGFR1, FGFR3
43in utero embryonic developmentGO:00017018.9FGFR1, FGFR2, TWIST1
44innate immune responseGO:00450878.7FGFR2, FGFR1, FGFR3
45negative regulation of transcription from RNA polymerase II promoterGO:00001228.4FGFR3, FGFR1, FGFR2, TWIST1

Molecular functions related to Synostosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082019.3FGFR1, FGFR2
2fibroblast growth factor-activated receptor activityGO:00050078.9FGFR2, FGFR3, FGFR1
3fibroblast growth factor bindingGO:00171348.8FGFR1, FGFR3, FGFR2
4protein tyrosine kinase activityGO:00047138.7FGFR2, FGFR1, FGFR3
5protein homodimerization activityGO:00428038.2FGFR2, FGFR1, TWIST1

Products for genes affiliated with Synostosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Synostosis

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet