Aliases & Classifications for Synostosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MeSH, 61UMLS
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Aliases & Descriptions for Synostosis:

Name: Synostosis 8 10 44


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Disease Ontology8 DOID:11971
MeSH33 D013580

Summaries for Synostosis

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Wikipedia:64 Synostosis means fusion of two bones, it can be normal in puberty, fusion of the epiphysis, or abnormal.... more...

MalaCards based summary: Synostosis is related to radioulnar synostosis and antley-bixler syndrome. An important gene associated with Synostosis is HOXA11 (homeobox A11), and among its related pathways are Signaling by FGFR3 mutants and Endochondral Ossification. The compounds pazopanib and regorafenib have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and brain, and related mouse phenotypes are renal/urinary system and no phenotypic analysis.

Disease Ontology:8 A dysostosis that results in abnormal fusing of adjacent bones.

Related Diseases for Synostosis

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Diseases related to Synostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 318)
idRelated DiseaseScoreTop Affiliating Genes
1radioulnar synostosis31.9HOXA11
2antley-bixler syndrome30.9FGFR2
3strabismus30.3FGFR2, FGFR3
4osteoglophonic dysplasia30.3FGFR1
5syndactyly30.3FGFR3, FGFR2
6osteochondroma30.3FGFR3
7achondroplasia30.3FGFR2, FGFR3
8pfeiffer syndrome30.3FGFR1, FGFR2
9ladd syndrome30.1FGFR2, FGFR3
10apert syndrome30.0FGFR3, FGFR2, FGFR1
11craniosynostosis30.0FGFR1, FGFR2, FGFR3, TWIST1
12crouzon syndrome30.0FGFR3, FGFR1, FGFR2
13jackson-weiss syndrome29.8FGFR1, FGFR3, FGFR2
14muenke syndrome29.7FGFR3, FGFR1, TWIST1, FGFR2
15saethre-chotzen syndrome29.3TWIST1, FGFR3, FGFR2, FGFR1
16acrocephalosyndactylia29.1TWIST1, FGFR3, FGFR2, FGFR1
17lambdoid synostosis10.6
18spondylocarpotarsal synostosis syndrome10.6
19congenital radio-ulnar synostosis10.5
20plagiocephaly10.5
21humeroradial synostosis10.4
22radioulnar synostosis with microcephaly, short stature, scoliosis, and mental retardation10.4
23beare-stevenson cutis gyrata syndrome10.3FGFR2
24ramer ladda syndrome10.3
25radioulnar synostosis with amegakaryocytic thrombocytopenia10.3
26humeroradioulnar synostosis10.3
27radioulnar synostosis retinal pigment abnormalities10.3
28mesomelic dysplasia, kantaputra type10.3
29symphalangism, proximal10.3
30nievergelt syndrome10.3
31microcephaly10.2
32ascher's syndrome10.2
33roberts syndrome10.2
34ivic syndrome10.2
35cervicitis10.2
36coronal synostosis, syndactyly and jejunal atresia10.2
37radio-ulnar synostosis type 110.2
38radio-ulnar synostosis type 210.2
39craniosynostosis - hydrocephalus - arnold-chiari malformation type i - radioulnar synostosis10.2
40acropectorovertebral dysplasia10.2
41antley-bixler syndrome with genital anomalies and disordered steroidogenesis10.2
42williams-beuren syndrome10.2
43mesomelia-synostoses syndrome10.2
44cenani-lenz syndactyly syndrome10.2
45microphthalmia with limb anomalies10.2
46tarsal-carpal coalition syndrome10.2
47otopalatodigital syndrome, type i10.2
48calcaneonavicular coalition10.2
49intracranial hypertension10.2
50brachydactyly mononen type10.2

Graphical network of the top 20 diseases related to Synostosis:



Diseases related to synostosis

Symptoms for Synostosis

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Drugs & Therapeutics for Synostosis

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Drug clinical trials:

Search ClinicalTrials for Synostosis

Search NIH Clinical Center for Synostosis

Genetic Tests for Synostosis

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Anatomical Context for Synostosis

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MalaCards organs/tissues related to Synostosis:

31
Bone, Bone marrow, Brain, Thyroid, Eye, Testes

Animal Models for Synostosis or affiliated genes

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Publications for Synostosis

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Articles related to Synostosis:

(show top 50)    (show all 586)
idTitleAuthorsYear
1
One-stage rotational osteotomy for congenital radioulnar synostosis. (25827142)
2015
2
Correction of hypotelorism in isolated metopic synostosis. (23848421)
2014
3
Surgical correction for unilateral lambdoid synostosis: a systematic review. (24978452)
2014
4
Isolated frontosphenoidal synostosis: a rare cause of synostotic frontal plagiocephaly. (24606403)
2014
5
Proximal radial diaphyseal segment resection for posttraumatic proximal radioulnar synostosis: a prospective study of 15 cases. (24768222)
2014
6
Post-traumatic humero-ulnar synostosis. (24732097)
2014
7
Improving ophthalmic outcomes in children with unilateral coronal synostosis by treatment with endoscopic strip craniectomy and helmet therapy rather than fronto-orbital advancement. (23791406)
2013
8
Early frontofacial symmetry after correction of unilateral coronal synostosis: frontoorbital advancement vs endoscopic strip craniectomy and helmet therapy. (23851767)
2013
9
Modified osteotomy (Kanaya's procedure) for congenital proximal radioulnar synostosis with posterior dislocation of radial head. (23821677)
2013
10
Bilateral coronal and sagittal synostosis in X-linked hypophosphatemic rickets: a case report. (23466123)
2013
11
Rapid re-synostosis following suturectomy in pediatric mice is age and location dependent. (23201269)
2013
12
Magnetic resonance imaging in isolated sagittal synostosis. (22801186)
2012
13
A family with radio-ulnar synostosis, scoliosis, and thick vermilion of lips: a novel syndrome or variant of GiuffrA"-Tsukahara syndrome? (22786695)
2012
14
Preoperative and postoperative developmental attainment in patients with sagittal synostosis: 5-year follow-up. (21284455)
2011
15
Proximal tibiofibular synostosis as a possible cause of a pseudoradicular syndrome: a case report. (21222100)
2011
16
Tibia vara deformity after below knee amputation and synostosis formation in children. (19352235)
2009
17
Three-dimensional motion analysis of compensatory movements in patients with radioulnar synostosis performing activities of daily living. (19499298)
2009
18
Two cases of feline ectromelia: autopodium ectromelia associated with humero-ulnar synostosis and zeugopodium ectromelia. (19560386)
2009
19
Increased frequency of left-handedness in patients with unilateral coronal synostosis. (19642752)
2009
20
Craniosynostosis, hydrocephalus, Chiari I malformation and radioulnar synostosis: probably a new syndrome. (19022412)
2009
21
Bilateral lambdoid and sagittal synostosis (BLSS): a unique craniosynostosis syndrome or predictable craniofacial phenotype? (19396832)
2009
22
Proximal radio-ulnar synostosis and nonunion after olecranon fracture tension-band wiring: a case report. (19393921)
2009
23
Unilateral radio-ulnar synostosis and idic-Y chromosome. (19239087)
2008
24
Humero-radial synostosis, microcephaly, short corpus callosum, and abnormal genitalia in sibs. (18553517)
2008
25
Zygomaticotemporal synostosis: a rare cause of progressive facial asymmetry. (17214532)
2007
26
Sagittal synostosis in X-linked hypophosphatemic rickets and related diseases. (17551721)
2007
27
Craniofacial anomalies, humero-radial synostosis, rhizomelic limb shortness: previously unrecognized autosomal recessive syndrome. (17304553)
2007
28
Frontosphenoidal synostosis: a rare cause of unilateral anterior plagiocephaly. (17891404)
2007
29
Heterotopic ossification causing proximal radioulnar synostosis after insertion of a radial head prosthesis. (16753242)
2006
30
Asymmetrical tetraphocomelia with radiohumeral synostosis. (16885632)
2006
31
Undiagnosed obstructive sleep apnea syndrome in children with syndromal craniofacial synostosis. (15213550)
2004
32
Bilateral aplasia of the thumb, proximal radioulnar synostosis and unilateral synostosis of metacarpals 4 and 5. (15083702)
2004
33
Hybrid of distraction osteogenesis unilateral frontal distraction and supraorbital reshaping in correction of unilateral coronal synostosis. (15547381)
2004
34
Posttraumatic distal radioulnar synostosis and distal radial epiphyseal arrest. (11881314)
2002
35
Clinical outcome of the modified pi-plasty procedure for sagittal synostosis. (11358093)
2001
36
The faith of a coronal suture grafted onto midline synostosis inducing dura and deprived from tensile stress. (11522177)
2001
37
Management of radioulnar synostosis with mobilization, anconeus interposition, and a forearm rotation assist splint. (10633900)
1999
38
The Antley-Bixler syndrome. A new case without radiohumeral synostosis. (9664207)
1998
39
Preoperative morphology and development in sagittal synostosis. (9672839)
1998
40
Surgical management of sagittal synostosis: a comparative analysis of strip craniectomy and calvarial vault remodeling. (9548524)
1997
41
Osteoblast-directed osteoclast metabolism from patients with premature coronal synostosis. (9145118)
1997
42
Long-term studies of metopic synostosis: frequency of cognitive impairment and behavioral disturbances. (8559809)
1996
43
Stability of fronto-orbital advancement in nonsyndromic bilateral coronal synostosis: a quantitative three-dimensional computed tomographic study. (8700973)
1996
44
Occipital plagiocephaly: deformation or lambdoid synostosis? II. A unifying theory regarding pathogenesis. (8841076)
1996
45
Outcome analysis of 85 patients undergoing the pi procedure for correction of sagittal synostosis. (8683282)
1996
46
Lambdoid synostosis. (7813157)
1994
47
Radio-ulnar synostosis following external fixation. (8294821)
1993
48
Treatment of posttraumatic radioulnar synostosis with excision and low-dose radiation. (8349985)
1993
49
Radiohumeral synostosis, femoral bowing, other skeletal anomalies and anal atresia, a variant example of Antley-Bixler syndrome? (8267929)
1993
50
A Case of Enlarged Parietal Foramina associated with Metropism and Irregular Synostosis of the Coronal Suture. (17104407)
1932

Variations for Synostosis

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Expression for genes affiliated with Synostosis

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Search GEO for disease gene expression data for Synostosis.

Pathways for genes affiliated with Synostosis

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Pathways related to Synostosis according to GeneCards Suite gene sharing:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4FGFR3, FGFR1
29.4FGFR3, FGFR1
39.3FGFR1, FGFR2
4
Show member pathways
8.8FGFR1, FGFR2, FGFR3
58.8FGFR1, FGFR2, FGFR3
6
Show member pathways
8.8FGFR1, FGFR2, FGFR3
7
Show member pathways
8.8FGFR1, FGFR2, FGFR3
8
Show member pathways
8.8FGFR1, FGFR2, FGFR3
9
Show member pathways
8.8FGFR3, FGFR1, FGFR2
10
Show member pathways
8.8FGFR3, FGFR2, FGFR1
118.8FGFR3, FGFR1, FGFR2
12
Show member pathways
8.8FGFR3, FGFR1, FGFR2
13
Show member pathways
8.8FGFR3, FGFR2, FGFR1
14
Show member pathways
8.8FGFR3, FGFR1, FGFR2
15
Show member pathways
8.8FGFR3, FGFR1, FGFR2
16
Show member pathways
8.8FGFR2, FGFR3, FGFR1
17
Show member pathways
8.8FGFR3, FGFR2, FGFR1
188.8FGFR3, FGFR1, FGFR2
19
Show member pathways
8.8FGFR1, FGFR3, FGFR2
208.8FGFR1, FGFR3, FGFR2
21
Show member pathways
8.8FGFR2, FGFR3, FGFR1
22
Show member pathways
8.8FGFR3, FGFR1, FGFR2
23
Show member pathways
Signaling Pathways in Glioblastoma36
8.8FGFR3, FGFR2, FGFR1
248.8FGFR3, FGFR2, FGFR1
25
Show member pathways
8.8FGFR2, FGFR3, FGFR1
26
Show member pathways
8.8FGFR2, FGFR1, FGFR3
27
Show member pathways
8.8FGFR2, FGFR1, FGFR3
28
Show member pathways
8.8FGFR2, FGFR1, FGFR3
29
Show member pathways
8.8FGFR2, FGFR1, FGFR3
30
Show member pathways
8.8FGFR2, FGFR1, FGFR3
31
Show member pathways
8.8FGFR2, FGFR1, FGFR3
328.8FGFR2, FGFR1, FGFR3
33
Show member pathways
8.8FGFR2, FGFR1, FGFR3
34
Show member pathways
8.8FGFR2, FGFR1, FGFR3
35
Show member pathways
8.8FGFR2, FGFR1, FGFR3
36
Show member pathways
8.8FGFR2, FGFR1, FGFR3
37
Show member pathways
8.8FGFR2, FGFR1, FGFR3
38
Show member pathways
8.8FGFR2, FGFR1, FGFR3
398.7FGFR1, FLNB, TWIST1
40
Show member pathways
8.4FGFR1, FGFR2, FLNB, FGFR3
41
Show member pathways
MAPK signaling pathway36
8.4FGFR2, FLNB, FGFR1, FGFR3
42
Show member pathways
8.4FGFR3, FLNB, FGFR2, FGFR1
438.0FGFR3, FGFR1, FGFR2, TWIST1

Compounds for genes affiliated with Synostosis

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Compounds related to Synostosis according to GeneCards Suite gene sharing:

(show all 24)
idCompoundScoreTop Affiliating Genes
1pazopanib50 1110.7FGFR3, FGFR1
2regorafenib50 1110.6FGFR2, FGFR1
3thalidomide44 50 60 1112.5FGFR2, FGFR3
4chondroitin sulfate44 2410.5FGFR2, FGFR1
5suramin44 28 1111.4FGFR1, FGFR2
6bromodeoxyuridine449.3FGFR2, FGFR1
7sulfate44 2410.2FGFR3, FGFR2
8fiin 1 hydrochloride609.2FGFR3, FGFR1, FGFR2
9su 5402609.2FGFR1, FGFR3, FGFR2
10pd 161570609.2FGFR3, FGFR2, FGFR1
11su5402449.2FGFR2, FGFR1, FGFR3
12pd 17307444 6010.1FGFR2, FGFR1, FGFR3
13progesterone44 28 60 24 1113.1HOXA11, FGFR2, FGFR1
14palifermin44 1110.1FGFR3, FGFR1, FGFR2
15ponatinib50 1110.1FGFR2, FGFR1, FGFR3
16phenylalanine449.1FGFR2, FGFR3, FGFR1
17phosphotyrosine449.1FGFR2, FGFR1, FGFR3
18lysine449.1FGFR2, FGFR1, FGFR3
19oligonucleotide449.0FGFR3, FGFR2, FGFR1
20vegf448.9FGFR1, FGFR2, FGFR3
21threonine448.8FGFR3, FGFR1, FGFR2
22paclitaxel44 50 1110.8TWIST1, FGFR2, FGFR1
23glutamate448.5FGFR1, FGFR2, FGFR3
24tyrosine448.2TWIST1, FGFR3, FGFR1, FGFR2

GO Terms for genes affiliated with Synostosis

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Cellular components related to Synostosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1focal adhesionGO:00059259.5FGFR3, FLNB
2cell cortexGO:00059389.3FGFR2, FLNB
3cytoplasmic membrane-bounded vesicleGO:00160238.8FGFR3, FGFR1, FGFR2
4nucleusGO:00056347.3HOXA11, TWIST1, FGFR2, FGFR1, FGFR3

Biological processes related to Synostosis according to GeneCards Suite gene sharing:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1organ inductionGO:00017599.9HOXA11, FGFR1
2positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:00900809.9FGFR3, FGFR1
3embryonic limb morphogenesisGO:00303269.8FGFR1, HOXA11
4fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:00356079.8FGFR2, FGFR1
5ventricular zone neuroblast divisionGO:00218479.8FGFR2, FGFR1
6mesenchymal cell differentiationGO:00487629.8FGFR1, FGFR2
7lens fiber cell developmentGO:00703079.7FGFR3, FGFR2
8negative regulation of mitosisGO:00458399.7FGFR3, FGFR2
9lung-associated mesenchyme developmentGO:00604849.7FGFR2, FGFR1
10branching involved in salivary gland morphogenesisGO:00604459.7FGFR1, FGFR2
11chondrocyte differentiationGO:00020629.7FGFR3, FGFR1
12positive regulation of cardiac muscle cell proliferationGO:00600459.7FGFR2, FGFR1
13bone morphogenesisGO:00603499.7FGFR2, FGFR3
14skeletal system morphogenesisGO:00487059.7FGFR2, FGFR1
15positive regulation of cell cycleGO:00457879.7FGFR1, FGFR2
16midbrain developmentGO:00309019.6FGFR1, FGFR2
17positive regulation of mesenchymal cell proliferationGO:00020539.6FGFR2, FGFR1
18ureteric bud developmentGO:00016579.6FGFR2, FGFR1
19outer ear morphogenesisGO:00424739.5TWIST1, FGFR1
20embryonic forelimb morphogenesisGO:00351159.5TWIST1, HOXA11
21negative regulation of epithelial cell proliferationGO:00506809.5FGFR2, FGFR3
22positive regulation of canonical Wnt signaling pathwayGO:00902639.5FGFR2, FGFR3
23skeletal system developmentGO:00015019.4FGFR3, FGFR1, HOXA11
24MAPK cascadeGO:00001659.4FGFR3, FGFR1
25embryonic digit morphogenesisGO:00427339.4HOXA11, TWIST1
26inner ear morphogenesisGO:00424729.4FGFR1, FGFR2
27embryonic cranial skeleton morphogenesisGO:00487019.4FGFR2, TWIST1
28odontogenesisGO:00424769.3TWIST1, FGFR2
29positive regulation of phospholipase activityGO:00105189.3FGFR3, FGFR1, FGFR2
30positive regulation of MAPK cascadeGO:00434109.2FGFR2, FGFR1, FGFR3
31peptidyl-tyrosine phosphorylationGO:00181089.2FGFR3, FGFR2, FGFR1
32phosphatidylinositol-mediated signalingGO:00480159.2FGFR2, FGFR1, FGFR3
33insulin receptor signaling pathwayGO:00082869.2FGFR2, FGFR1, FGFR3
34protein autophosphorylationGO:00467779.2FGFR1, FGFR2, FGFR3
35fibroblast growth factor receptor signaling pathwayGO:00085439.2FGFR2, FGFR1, FGFR3
36Fc-epsilon receptor signaling pathwayGO:00380959.2FGFR2, FGFR1, FGFR3
37epidermal growth factor receptor signaling pathwayGO:00071739.2FGFR1, FGFR2, FGFR3
38neurotrophin TRK receptor signaling pathwayGO:00480119.2FGFR2, FGFR1, FGFR3
39positive regulation of epithelial cell proliferationGO:00506799.1TWIST1, FGFR2
40neuron migrationGO:00017649.1TWIST1, FGFR1
41positive regulation of ERK1 and ERK2 cascadeGO:00703749.0FGFR2, FGFR3
42positive regulation of cell proliferationGO:00082849.0FGFR2, FGFR1, FGFR3
43in utero embryonic developmentGO:00017018.9TWIST1, FGFR2, FGFR1
44innate immune responseGO:00450878.7FGFR3, FGFR1, FGFR2
45negative regulation of transcription from RNA polymerase II promoterGO:00001228.4FGFR3, FGFR2, TWIST1, FGFR1

Molecular functions related to Synostosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082019.3FGFR1, FGFR2
2fibroblast growth factor-activated receptor activityGO:00050078.9FGFR3, FGFR1, FGFR2
3fibroblast growth factor bindingGO:00171348.8FGFR3, FGFR1, FGFR2
4protein tyrosine kinase activityGO:00047138.7FGFR2, FGFR1, FGFR3
5protein homodimerization activityGO:00428038.2FGFR1, FGFR2, TWIST1

Sources for Synostosis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet