MCID: SYN005
MIFTS: 45

Synostosis malady

Category: Bone diseases

Aliases & Classifications for Synostosis

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Aliases & Descriptions for Synostosis:

Name: Synostosis 11 50 39 13

Classifications:



External Ids:

Disease Ontology11 DOID:11971
MeSH39 D013580

Summaries for Synostosis

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Wikipedia:71 Synostosis (plural: synostoses) is fusion of two bones. It can be normal in puberty, fusion of the... more...

MalaCards based summary: Synostosis is related to antley-bixler syndrome without genital anomalies or disordered steroidogenesis and apert syndrome. An important gene associated with Synostosis is HOXA11 (Homeobox A11), and among its related pathways are Central carbon metabolism in cancer and Vemurafenib Pathway, Pharmacodynamics. Affiliated tissues include bone, skin and bone marrow, and related mouse phenotypes are muscle and renal/urinary system.

Disease Ontology:11 A dysostosis that results in abnormal fusing of adjacent bones.

Related Diseases for Synostosis

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Diseases related to Synostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1antley-bixler syndrome without genital anomalies or disordered steroidogenesis32.5FGFR1, FGFR2, FGFR3
2apert syndrome32.3FGFR2, FGFR3, RAB23
3spondylocarpotarsal synostosis syndrome12.2
4radioulnar synostosis with amegakaryocytic thrombocytopenia12.1
5radioulnar synostosis12.0
6radioulnar synostosis with amegakaryocytic thrombocytopenia 211.9
7congenital radio-ulnar synostosis11.9
8humeroradial synostosis11.8
9humeroradioulnar synostosis11.8
10lambdoid synostosis11.8
11tibio-fibular synostosis11.7
12humero-ulnar synostosis11.7
13radioulnar synostosis with microcephaly, short stature, scoliosis, and mental retardation11.7
14radioulnar synostosis, unilateral, with developmental retardation and hypotonia11.7
15coronal synostosis, syndactyly and jejunal atresia11.7
16radio-ulnar synostosis type 111.7
17radio-ulnar synostosis type 211.7
18craniosynostosis-hydrocephalus-arnold-chiari malformation type i-radioulnar synostosis syndrome11.7
19muenke syndrome11.6
20cleft palate colobomata radial synostosis deafness11.6
21congenital heart disease radio ulnar synostosis mental retardation11.6
22synostosis of talus and calcaneus short stature11.6
23fgfr3-related isolated coronal synostosis11.6
24fgfr2-related isolated coronal synostosis11.6
25deafness-genital anomalies-metacarpal and metatarsal synostosis syndrome11.6
26humero-radial synostosis, unilateral11.6
27humero-radial synostosis, bilateral11.6
28humero-radio-ulnar synostosis, unilateral11.6
29humero-radio-ulnar synostosis, bilateral11.6
30radio-ulnar synostosis, unilateral11.6
31radio-ulnar synostosis, bilateral11.6
32humero-ulnar synostosis, unilateral11.6
33humero-ulnar synostosis, bilateral11.6
34calcaneonavicular coalition11.3
35mesomelic dysplasia, kantaputra type11.2
36craniosynostosis11.1
37saethre-chotzen syndrome11.0
38craniofrontonasal dysplasia11.0
39klippel-feil syndrome10.9
40jorgenson lenz syndrome10.9
41liebenberg syndrome10.8
42small patella syndrome10.8
43acrofacial dysostosis 1, nager type10.8
44antley-bixler syndrome with genital anomalies and disordered steroidogenesis10.8
45syndactyly, mesoaxial synostotic, with phalangeal reduction10.8
46abruzzo-erickson syndrome10.8
47carpenter syndrome10.8
48brachydactyly elbow wrist dysplasia10.8
49ramer ladda syndrome10.8
503mc syndrome 210.7

Graphical network of the top 20 diseases related to Synostosis:



Diseases related to synostosis

Symptoms & Phenotypes for Synostosis

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MGI Mouse Phenotypes related to Synostosis according to GeneCards Suite gene sharing:

41 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.9FGFR1, FGFR2, GSC, MECOM, MSX2, NOG
2MP:00053678.7FGFR1, FGFR2, FGFR3, GLI3, HOXA11, LRP4
3MP:00053778.5EFNB1, FGFR1, FGFR2, FGFR3, GLI3, GSC
4MP:00053898.1EFNB1, FGFR1, FGFR2, FGFR3, GDF5, GLI3
5MP:00053918.1EFNB1, FGFR1, FGFR2, FGFR3, GLI3, GSC
6MP:00053858.0FGFR1, FGFR2, FLNB, GLI3, GSC, MECOM
7MP:00053807.6EFNB1, FGFR1, FGFR2, GLI3, GSC, LRP4
8MP:00053797.5EFNB1, FGFR1, FGFR2, GLI3, GSC, HOXA11
9MP:00053867.1FGFR1, FGFR2, FGFR3, FLNB, GSC, LRP4
10MP:00107716.6EFNB1, FGFR1, FGFR2, FGFR3, GLI3, GSC
11MP:00053886.6EFNB1, FGFR2, FGFR3, FLNB, GLI3, GSC
12MP:00053816.3EFNB1, FGFR1, FGFR2, FGFR3, GLI3, GSC
13MP:00053846.2BHLHA9, EFNB1, FGFR1, FGFR2, FGFR3, FLNB
14MP:00036316.2EFNB1, FGFR1, FGFR2, FGFR3, FLNB, GLI3
15MP:00053905.7EFNB1, FGFR1, FGFR2, FGFR3, FLNB, GDF5
16MP:00053825.7EFNB1, FGFR1, FGFR2, FGFR3, FLNB, GLI3
17MP:00053715.3BHLHA9, EFNB1, FGFR1, FGFR2, FGFR3, FLNB
18MP:00053784.5EFNB1, FGFR1, FGFR2, FGFR3, FLNB, GDF5
19MP:00107684.1EFNB1, FGFR1, FGFR2, FGFR3, FLNB, GDF5

Drugs & Therapeutics for Synostosis

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Drugs for Synostosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Tranexamic AcidapprovedPhase 4, Phase 32571197-18-85526
Synonyms:
08455_FLUKA
1197-17-7
1197-18-8
1ceb
3-14-00-00868 (Beilstein Handbook Reference)
4-(Aminomethyl)-Cyclohexanecarboxylic Acid
4-(Aminomethyl)cyclohexanecarboxylic acid
4-(aminomethyl)cyclohexane-1-carboxylic acid
857653_ALDRICH
A0236
AB00052260
AB1003647
AC-4687
AC1L1KJH
AC1Q50F3
AC1Q546D
AC1Q5U04
ALBB-006013
AMCA
AMCHA
AMH
AR-1F6595
Acide tranexamique
Acide tranexamique [INN-French]
Acido tranexamico
Acido tranexamico [INN-Spanish]
Acidum tranexamicum
Acidum tranexamicum [INN-Latin]
Amikapron
Amstat
Anvitoff
BAY 3517
BPBio1_000069
BRN 2207452
BSPBio_000061
BSPBio_002837
CAS-1197-18-8
CHEBI:48669
CHEMBL292500
CHEMBL877
CID5526
CL 65336
CL-65336
Carxamin
Cyclocapron
Cyklokapron
Cyklokapron (TN)
D01136
DB00302
DV 79
DV-79
DV79
DivK1c_000655
EINECS 214-818-2
Emorhalt
Exacyl
Frenolyse
HMS1568D03
HMS1921F08
HMS2092P03
HMS502A17
Hexapromin
Hexatron
I04-0993
IDI1_000655
KABI 2161
KBio1_000655
KBio2_001871
KBio2_004439
KBio2_007007
KBio3_002337
KBioGR_000511
 
KBioSS_001871
LS-56611
LS-56612
LT00159441
Mastop
MolPort-001-792-390
MolPort-002-512-008
NCGC00016569-01
NCGC00016569-02
NCGC00016569-03
NCGC00094944-01
NCGC00094944-02
NINDS_000655
NSC 291305
NSC291305
Oprea1_786414
Prestwick0_000171
Prestwick1_000171
Prestwick2_000171
Prestwick3_000171
Prestwick_476
RP 18,429
Rikavarin
Rikavarin (TN)
Rikavarin-S
SPBio_000689
SPBio_001982
SPECTRUM1502026
STK503668
STOCK1N-16183
Spectrum2_000655
Spectrum3_001189
Spectrum4_000046
Spectrum5_001258
Spectrum_001391
Spiramin
Tamcha
Tranex
Tranexamate
Tranexamic acid (JP15/USAN/INN)
Tranexamic acid [USAN:INN:BAN:JAN]
Tranexamic acid cis-form
Tranexamsaeure
Tranexan
Tranexmic acid
Tranhexamic acid
Trans AMCHA
Trans-1-(Aminomethyl)cyclohexane-4-carboxylic acid
Trans-4-(Aminomethyl)-1-cyclohexanecarboxylic acid
Trans-p-(Aminomethyl)cyclohexanecarboxylic
Transamin
Transamin (TN)
Transamlon
Trasamlon
UNII-6T84R30KC1
Ugurol
WLN: L6TJ AVQ D1Z -T
cis-4-(Aminomethyl)cyclohexanecarboxylic acid
cis-4-Aminomethylcyclohexane-1-carboxylic acid
cis-AMCHA
t-AMCHA
tranexamic acid
tranexmic acid
trans-1-Aminomethylcyclohexane-4-carboxylic acid
trans-4-(Aminomethyl)cyclohexane-1-carboxylic acid
trans-4-(Aminomethyl)cyclohexane-carboxylic acid
trans-4-(Aminomethyl)cyclohexanecarboxylic acid
trans-4-(Aminomethyl)cyclohexanecarboxylic acid ester
trans-4-Aminomethylcyclohexane-1-carboxylic acid
trans-4-aminomethylcyclohexane-1-carboxylic acid
trans-Amcha
trans-Tranexamic acid
trans-p-(Aminomethyl)cyclohexanecarboxylic acid
2Antifibrinolytic AgentsPhase 4, Phase 3, Phase 2, Phase 1459
3HemostaticsPhase 4, Phase 3, Phase 2, Phase 11359
4CoagulantsPhase 4, Phase 3, Phase 2, Phase 11428
5
Aminocaproic Acidapproved, investigationalPhase 2, Phase 12660-32-2564
Synonyms:
.epsilon. S
.epsilon.-Aminocaproic acid
.epsilon.-Aminohexanoic acid
.epsilon.-Leucine
.epsilon.-Norleucine
.omega.-Aminocaproic acid
.omega.-Aminohexanoic acid
1319-82-0
177 J.D
177 J.D.
1cea
3kiv
6 Aminocaproic Acid
6 Aminohexanoic Acid
6-Amino-Hexanoate
6-Amino-Hexanoic acid
6-Amino-N-hexanoate
6-Amino-N-hexanoic acid
6-Amino-n-hexanoic acid
6-Aminocaproate
6-Aminocaproic acid
6-Aminohexanoate
6-Aminohexanoic acid
6-amino-hexanoic acid
6-amino-n-caproate
6-amino-n-caproic acid
6-aminohexanoate
6-aminohexanoic acid
60-32-2
87867-96-7
93208-38-9
A 7824
A0312
A2504_SIGMA
A7824_SIGMA
AB00051911
AC-035
AC1L19IP
AC1Q54EY
ACS
AI3-14512
AKOS000118734
AMICAR
AMINOCAPROIC
Acepramin
Acepramine
Acid, 6-Aminocaproic
Acid, 6-Aminohexanoic
Acid, epsilon-Aminocaproic
Acide aminocaproique
Acide aminocaproique [French]
Acide aminocaproique [INN-French]
Acide aminocaproque
Acide aminocaproïque
Acido aminocaproico
Acido aminocaproico [DCIT,Spanish]
Acido aminocaproico [INN-Spanish]
Acidum Aminocaproicum
Acidum aminocaproicum
Acidum aminocaproicum [INN-Latin]
Acidum aminocaproicum [Latin]
Acikaprin
Afibrin
Ahx
Amicar
Amicar (TN)
Amicar, |A-amino caproic acid, |A-Ahx, 6-aminohexanoic acid, Aminocaproic acid
Amikar
Aminocaproate
Aminocaproic
Aminocaproic Acid In Plastic Container
Aminocaproic Acids
Aminocaproic acid
Aminocaproic acid (USP)
Aminocaproic acid (USP/INN)
Aminocaproic acid [USAN:BAN:INN]
Aminocaproic acid [USAN:INN:BAN]
Aminocapronsäure
Aminohexanoic acid
Aminokapron
Atsemin
BIDD:GT0162
BPBio1_001056
BRN 0906872
BSPBio_000960
C02378
C3BDD377-8F43-4BEC-900A-D5850050BA82
C6H13NO2
CAS-60-32-2
CBDivE_004370
CCRIS 7706
CHEBI:16586
CHEMBL1046
CID564
CL 10304
CL-10304
CY 116
CY-116
CY116
Caplamin
Capracid
Capralense
Capramol
Capranol
Caproamin
Caprocid
Caprolisin
D00160
D015119
DB00513
DB04134
DivK1c_000551
EACA
EACS
EINECS 200-469-3
EPSILON-AMINOCAPROIC ACID
EU-0100082
Eaca
Eaca kabi
Epsamon
 
Epsicaprom
Epsicapron
Epsikapron
Epsilcapramin
Epsilcapramine
Epsillon-Aminocaproate
Epsillon-Aminocaproic acid
Epsillon-Aminocaproic acid' Epsilcapramin
Epsilon S
Epsilon-Aminocaproic Acid
Epsilon-Aminocapronsaeure
Epsilon-aminocapronzuur
H-6-Ahx-OH
H-EAhx-OH
H-epsilon-Acp-OH
HEXANOIC ACID,6-AMINO
HMS1570P22
HMS1920C07
HMS2091I07
HMS501L13
HSDB 3005
Hemocaprol
Hemopar
Hepin
IDI1_000551
InChI=1/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9
Ipsilon
JD 177
KBio1_000551
KBio2_000398
KBio2_002966
KBio2_005534
KBioGR_000586
KBioSS_000398
Kyselina omega-aminokapronova
Kyselina omega-aminokapronova [Czech]
LMFA01100035
LS-7191
Lopac-A-7824
Lopac0_000082
MLS001335991
MLS002695931
MolPort-001-779-881
NCGC00015092-01
NCGC00015092-02
NCGC00015092-03
NCGC00015092-07
NCGC00093587-01
NCGC00093587-02
NCGC00093587-03
NCGC00093587-04
NINDS_000551
NSC 26154
NSC 400230
NSC-26154
NSC212532
NSC26154
NSC400230
Omega-Aminocaproate
Omega-Aminocaproic acid
Omega-Aminohexanoate
Omega-Aminohexanoic acid
Prestwick0_000960
Prestwick1_000960
Prestwick2_000960
Prestwick3_000960
Respramin
S04-0132
S1671_Selleck
SMR000059162
SPBio_000202
SPBio_003109
SPECTRUM1500114
STK246894
Spectrum2_000131
Spectrum4_000143
Spectrum5_000780
Spectrum_000038
TL8003819
UNII-U6F3787206
WLN: Z5VQ
Z
acide aminocaproque
amicar
bmse000394
e-Amino-N-hexanoate
e-Amino-N-hexanoic acid
e-Aminocaproate
e-Aminocaproic acid
e-Aminocaproic acid USP
e-Aminohexanoate
e-Aminohexanoic acid
e-Leucine
e-Norleucine
epsilcapramine
epsilon Aminocaproic Acid
epsilon S
epsilon-Ahx
epsilon-Amino-N-hexanoate
epsilon-Amino-N-hexanoic acid
epsilon-Amino-n-caproic acid
epsilon-Amino-n-hexanoic acid
epsilon-Aminocaproate
epsilon-Aminocaproic acid
epsilon-Aminocaproic acid (JAN)
epsilon-Aminocaproic acid USP
epsilon-Aminohexanoate
epsilon-Aminohexanoic acid
epsilon-Leucine
epsilon-Norleucine
epsilon-S
epsilon-aminocaproate
nchembio.104-comp21
nchembio.2007.30-comp14
omega-Aminocaproic acid
omega-Aminohexanoic acid
w-Aminocaproate
w-Aminocaproic acid
w-Aminohexanoate
w-Aminohexanoic acid
Ácido aminocapróico
6
Mentholapproved23532216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol
7Analgesics11287
8Peripheral Nervous System Agents22776
9
Bilirubin112635-65-45280352
Synonyms:
(4Z,15Z)-Bilirubin IXa
(Z,Z)-Bilirubin IXa
1,10,19,22,23,24-Hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-Biline-8,12-dipropionate
1,10,19,22,23,24-Hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-Biline-8,12-dipropionic acid
2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8,12-dipropanoate
2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8,12-dipropanoic acid
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-((3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-3-yl)propanoate
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-((3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
 
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-[(Z)-(3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-1H-pyrrol-2-yl)methyl)-4-methyl-5-[(Z)-(4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene
3-[2-[[3-(2-Carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate
3-[2-[[3-(2-Carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
3-[2-[[3-(2-Carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate
3-[2-[[3-(2-Carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
Bilirubin
Bilirubin IX-alpha
Cholerythrin
Hematoidin
10Calcium, Dietary5525
11CalamusNutraceutical419

Interventional clinical trials:

(show all 31)
idNameStatusNCT IDPhase
1The Efficacy and Population Pharmacokinetics of Tranexamic Acid for Craniosynostosis SurgeryRecruitingNCT02188576Phase 4
2Tranexamic Acid for Craniofacial SurgeryTerminatedNCT00722436Phase 4
3Comparison of a Bone Product to Bone Dust in Ossification of Small Calvarial Defects.WithdrawnNCT01006148Phase 4
4Blood Loss and Transfusion Requirement in Infants Treated With Tranexamic AcidUnknown statusNCT01094977Phase 3
5A Trial to Evaluate the Safety, Local Tolerability, Pharmacokinetics and Pharmacodynamics of LDE225 on Skin Basal Cell Carcinomas in Gorlin Syndrome PatientsCompletedNCT00961896Phase 2
6Efficacy of Amicar for Children Having Craniofacial SurgeryRecruitingNCT02229968Phase 2
7Stem Cells and Tibial FracturesCompletedNCT00632034Phase 1
8Amicar Pharmacokinetics of Children Having Craniofacial SurgeryCompletedNCT00912119Phase 1
9Mononucleotide Autologous Stem Cells and Demineralized Bone Matrix in the Treatment of Non Union/Delayed FracturesUnknown statusNCT01435434
10The Effect of Gender on the Consumption of Pain Medication in Infants Undergoing Craniosynostosis Repair or Untethering of Cord in ITUUnknown statusNCT01996163
11Treatment of Displaced Lateral Clavicle Fractures Using a Locking Compression Plate With Lateral ExtensionCompletedNCT02256059
12Evaluation of Effects of Clavicular Hook Plate on Subacromial SpaceCompletedNCT01205763
13Qualitative and Quantitative Study Which Aims to Determine the Specifics of the Announcement for the Diagnosis of Patients With Craniosynostosis and Their Parents to Better Support Them in Their CareCompletedNCT02287805
14Effect of Tranexamic Acid Based on Pharmacokinetics in Pediatric Patients Undergoing Craniosynostosis Surgery: Randomized Controlled TrialCompletedNCT02180321
15Nautilus: Dynamic Craniotomy; New Surgical Technique and Preliminary ResultsCompletedNCT01672619
16Genetic Analysis of Craniosynostosis, Philadelphia TypeCompletedNCT00367796
17Child and Infant Learning ProjectCompletedNCT00077831
18Effectiveness of Tortle Midliner Positioning System on the Prevention and Treatment of Cranial Molding Deformities in Preterm InfantsCompletedNCT02366936
19National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular ConditionsCompletedNCT01322165
20Transtibial Amputation Outcomes StudyRecruitingNCT01821976
21Network Of Clinical Research Studies On Craniosynostosis, Skull Malformations With Premature Fusion Of Skull BonesRecruitingNCT03025763
22Cancer in Inherited Bone Marrow Failure SyndromesRecruitingNCT00027274
23MRI for Non-invasive Evaluation of Brain StressRecruitingNCT01898650
24Treatment of Proximal Interphalangeal Joint Injuries. Clinical Efficiency of Syndactyly Treatment and Digital CompressionRecruitingNCT02548260
25Osteogenic Profiling of Tissue From Children With CraniosynostosisRecruitingNCT00773643
26Irradiated Blood Versus Non Irradiated Blood Transfusions in Craniosynostosis RepairRecruitingNCT02483702
27Clinical Study of Muenke Syndrome (FGFR3-Related Craniosynostosis)RecruitingNCT00106977
28Syndactyly Repair: Comparison of Skin Graft and No Skin Graft TechniquesActive, not recruitingNCT01416090
29Cranial Cup Use for the Prevention of Positional Head Shape Deformity in the NICUTerminatedNCT01218087
30Endoscopic Treatment for Isolated, Single Suture CraniosynostosisWithdrawnNCT00769847
31Hanger Helmet StudyWithdrawnNCT02561728

Search NIH Clinical Center for Synostosis


Cochrane evidence based reviews: synostosis

Genetic Tests for Synostosis

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Anatomical Context for Synostosis

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MalaCards organs/tissues related to Synostosis:

36
Bone, Skin, Bone marrow, Brain, Thyroid, Eye, Testes

Publications for Synostosis

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Articles related to Synostosis:

(show top 50)    (show all 658)
idTitleAuthorsYear
1
Treated Unilateral Lambdoid Synostosis Using Cranium Distraction Osteogenesis With Z-shaped Osteotomy. (28059851)
2017
2
Squamous Suture Synostosis: A Review With Emphasis on Cranial Morphology and Involvement of Other Cranial Sutures. (27831981)
2017
3
Comparison of Intracranial Volume and Cephalic Index After Correction of Sagittal Synostosis With Spring-assisted Surgery or Pi-plasty. (26963298)
2016
4
The Management of Nonsyndromic, Isolated Sagittal Synostosis. (26825739)
2016
5
Cerebrospinal fluid collections in sagittal suture synostosis. (26767840)
2016
6
Perinatal features and rate of cesarean section in newborns with non-syndromic sagittal synostosis. (27060068)
2016
7
Unilateral coronal synostosis: can we trust the sagittal suture as a landmark for the underlying superior sagittal sinus? (26745648)
2016
8
Combat-related bridge synostosis versus traditional transtibial amputation: comparison of military-specific outcomes. (26644067)
2016
9
Minimally invasive single-session double-level rotational osteotomy of the forearm bones to correct fixed pronation deformity in congenital proximal radioulnar synostosis. (27312798)
2016
10
Long-term results after a free vascularized adipofascial graft for congenital proximal radioulnar synostosis with an average follow-up of 10 years: a series of four cases. (27422459)
2016
11
Stepwise Removal of The Fused Midline Parietal Bone to Avoid Superior Sagittal Sinus Injury in Infants with Sagital Synostosis. (27593802)
2016
12
Surgical correction of lambdoid synostosis - New technique and first results. (27595190)
2016
13
Surgical Treatment of Posttraumatic Radioulnar Synostosis. (26977328)
2016
14
Volume measurements on three-dimensional photogrammetry after extended strip versus total cranial remodeling for sagittal synostosis: A comparative cohort study. (27591089)
2016
15
Rescue of Premature Coronal Suture Fusion With TGF-I^2 Neutralizing Antibody in Rabbits With Delayed-Onset Synostosis. (27505182)
2016
16
Quantifying Craniometric Change Early After Fronto-Orbital Advancement in Metopic Synostosis. (27513770)
2016
17
A new quantitative image-based method for evaluation of bony temporal hollowing in metopic synostosis. (27125314)
2016
18
Thoracoscopic Resection of a Symptomatic, Congenital Rib Synostosis. (27000588)
2016
19
Objective Assessment of the Interfrontal Angle for Severity Grading and Operative Decision-Making in Metopic Synostosis. (27119927)
2016
20
Isolated Unilateral Frontosphenoidal Suture Synostosis in Six Patients: Lessons Learned in Diagnosis and Treatment. (27152571)
2016
21
Anthropometric Outcomes following Fronto-Orbital Advancement for Metopic Synostosis. (27119926)
2016
22
Synostosis of proximal phalangeal bases for loss of distal metacarpal. (27904227)
2016
23
Monozygotic twins presenting with isolated sagittal and bicoronal synostosis, respectively. (26925815)
2016
24
The Significance of Squamosal Suture Synostosis. (27438438)
2016
25
Internal Distraction Osteogenesis With Piezosurgery Oblique Osteotomy of Supraorbital Margin of Frontal Bone for the Treatment of Unilateral Coronal Synostosis. (27845963)
2016
26
Minimally Invasive Strip Craniectomy Simplifies Anesthesia Practice in Patients With Isolated Sagittal Synostosis. (28005739)
2016
27
Photometric evaluation of cranial and facial symmetry in hemicoronal single suture synostosis treated with surgical fronto-orbital remodeling. (27288326)
2016
28
Symptomatic Rhizarthritis in a Bilateral Scaphotrapezial Synostosis. (27616832)
2016
29
Distal tibiofibular synostosis after surgically resolved ankle fractures: An epidemiological, clinical and morphological evaluation of a patient sample. (27645618)
2016
30
Diaphyseal tibiofibular synostosis in professional athletes: Report of 2 cases. (26615768)
2016
31
Protein-altering MYH3 variants are associated with a spectrum of phenotypes extending to spondylocarpotarsal synostosis syndrome. (27381093)
2016
32
Capitate-trapezoid synostosis: Analysis of an early bronze age case and review of the literature. (27813627)
2016
33
Minimally Invasive Strip Craniectomy Simplifies Anesthesia Practice in Patients With Isolated Sagittal Synostosis. (27579560)
2016
34
Concurrent occurrence of an inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving MAP2K2 in a patient with developmental delay, distinctive facial features, and lambdoid synostosis. (27751966)
2016
35
The metopic index: an anthropometric index for the quantitative assessment of trigonocephaly from metopic synostosis. (27153376)
2016
36
Endoscope-assisted management of sagittal synostosis: wide vertex suturectomy and barrel stave osteotomies versus narrow vertex suturectomy. (27611899)
2016
37
Plagiocephaly due to Frontosphenoidal Suture Synostosis: Report of 2 Cases and Literature Review. (26960206)
2016
38
Perception of children's faces with unilateral coronal synostosis-an eye-tracking investigation. (26231563)
2015
39
Lambdoid Synostosis Versus Positional Posterior Plagiocephaly, a Comparison of Skull Base and Shape of Calvarium Using Computed Tomography Imaging. (26335322)
2015
40
New Pattern of Sutural Synostosis Associated With TWIST Gene Mutation and Saethre-Chotzen Syndrome: Peace Sign Synostosis. (26114524)
2015
41
Adipofascial radial artery perforator flap interposition to treat post-traumatic radioulnar synostosis in a patient with head injury. (25725026)
2015
42
Distraction Osteogenesis Versus Conventional Fronto-Orbital Advancement for the Treatment of Unilateral Coronal Synostosis: A Comparison of Perioperative Morbidity and Short-Term Outcomes. (26335320)
2015
43
Frontosphenoid synostosis: an unusual cause of anterior plagiocephaly. (25469893)
2015
44
Mutations in MECOM, Encoding Oncoprotein EVI1, Cause Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia. (26581901)
2015
45
Association of achondroplasia with sagittal synostosis and scaphocephaly in two patients, an underestimated condition? (25691418)
2015
46
Progressive valgus deformity of the donor-site ankle after extraperiosteal harvesting the fibular shaft in children. Treatment with osteotomy and synostosis at one session. (26719617)
2015
47
Operative Management of Nonsyndromic Sagittal Synostosis: A Head-to-Head Meta-analysis of Outcomes Comparing 3 Techniques. (26080168)
2015
48
Effects of open and endoscopic surgery on skull growth and calvarial vault volumes in sagittal synostosis. (25569396)
2015
49
Incidence and clinical relevance of tibiofibular synostosis in fractures of the ankle which have been treated surgically. (26130350)
2015
50
Surgical Considerations for Massive Tarsal Coalitions in Multiple Synostosis Syndrome: A Case Report. (25799911)
2015

Variations for Synostosis

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Expression for genes affiliated with Synostosis

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Search GEO for disease gene expression data for Synostosis.

Pathways for genes affiliated with Synostosis

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GO Terms for genes affiliated with Synostosis

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Cellular components related to Synostosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00056346.2BHLHA9, EFNB1, FGFR1, FGFR2, FGFR3, GLI3

Biological processes related to Synostosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 51)
idNameGO IDScoreTop Affiliating Genes
1embryonic skeletal joint morphogenesisGO:006027210.8HOXA11, NOG
2branching involved in salivary gland morphogenesisGO:006044510.8FGFR1, FGFR2
3fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:003560710.8FGFR1, FGFR2
4lung-associated mesenchyme developmentGO:006048410.8FGFR1, FGFR2
5cranial suture morphogenesisGO:006036310.8MSX2, TWIST1
6endochondral bone growthGO:000341610.8FGFR3, MSX2
7organ inductionGO:000175910.8FGFR1, HOXA11
8embryonic digestive tract morphogenesisGO:004855710.8FGFR2, GLI3
9orbitofrontal cortex developmentGO:002176910.7FGFR1, FGFR2
10outer ear morphogenesisGO:004247310.7FGFR1, TWIST1
11outflow tract septum morphogenesisGO:000314810.7FGFR2, MSX2
12frontal suture morphogenesisGO:006036410.7GLI3, MSX2
13hindlimb morphogenesisGO:003513710.7GDF5, TWIST1
14embryonic forelimb morphogenesisGO:003511510.6HOXA11, MSX2, TWIST1
15fibroblast growth factor receptor signaling pathwayGO:000854310.6FGFR1, FGFR2, FGFR3
16bone morphogenesisGO:006034910.6FGFR2, FGFR3, MSX2
17ventricular zone neuroblast divisionGO:002184710.5FGFR1, FGFR2
18anatomical structure developmentGO:004885610.5GLI3, LRP4
19mesenchymal cell differentiationGO:004876210.5FGFR1, FGFR2, NOG
20negative regulation of osteoblast differentiationGO:004566810.5FGFR1, NOG, TWIST1
21odontogenesisGO:004247610.5FGFR2, MSX2, TWIST1
22positive regulation of epithelial cell proliferationGO:005067910.5FGFR2, NOG, TWIST1
23phosphatidylinositol phosphorylationGO:004685410.5FGFR1, FGFR2, FGFR3
24phosphatidylinositol-3-phosphate biosynthetic processGO:003609210.5FGFR1, FGFR2, FGFR3
25phosphatidylinositol-mediated signalingGO:004801510.5FGFR1, FGFR2, FGFR3
26anterior/posterior pattern specificationGO:000995210.5GLI3, HOXA11, MSX2
27positive regulation of MAPK cascadeGO:004341010.5FGFR1, FGFR2, FGFR3
28lung developmentGO:003032410.5FGFR1, FGFR2, GLI3
29osteoblast differentiationGO:000164910.5MSX2, NOG, TWIST1
30positive regulation of phospholipase activityGO:001051810.5FGFR1, FGFR2, FGFR3
31regulation of phosphatidylinositol 3-kinase signalingGO:001406610.4FGFR1, FGFR2, FGFR3
32chondrocyte differentiationGO:000206210.4FGFR1, FGFR3, GDF5
33BMP signaling pathwayGO:003050910.3LRP4, MSX2, NOG
34positive regulation of chondrocyte differentiationGO:003233210.3GDF5, GLI3, HOXA11
35ureteric bud developmentGO:000165710.3FGFR1, FGFR2, NOG
36limb developmentGO:006017310.3GLI3, LRP4, NOG
37positive regulation of osteoblast differentiationGO:004566910.3GLI3, MSX2, NELL1
38proximal/distal pattern formationGO:000995410.2GLI3, HOXA11, LRP4
39embryonic skeletal system morphogenesisGO:004870410.2GLI3, GSC, TWIST1
40middle ear morphogenesisGO:004247410.2FGFR1, GSC, NOG
41cell-cell signalingGO:000726710.2EFNB1, FGFR2, FGFR3, GDF5
42skeletal system developmentGO:000150110.1FGFR1, FGFR3, HOXA11, NOG
43dorsal/ventral pattern formationGO:000995310.1GLI3, HOXA11, LRP4, NOG
44regulation of gene expressionGO:001046810.0FGFR1, GLI3, HOXA11, NELL1
45in utero embryonic developmentGO:000170110.0FGFR1, FGFR2, GLI3, NOG, TWIST1
46positive regulation of neuron differentiationGO:00456669.9FGFR1, GDF5, TCF12
47negative regulation of transcription, DNA-templatedGO:00458929.7GLI3, MECOM, MSX2, TBX22, TWIST1
48wound healingGO:00420609.7GLI3, MSX2, NOG
49embryonic digit morphogenesisGO:00427339.6GLI3, HOXA11, LRP4, MSX2, NOG, TWIST1
50embryonic limb morphogenesisGO:00303269.2FGFR1, GDF5, GLI3, HOXA11, LRP4, MSX2

Molecular functions related to Synostosis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
11-phosphatidylinositol-3-kinase activityGO:001630310.6FGFR1, FGFR2, FGFR3
2fibroblast growth factor bindingGO:001713410.6FGFR1, FGFR2, FGFR3
3fibroblast growth factor-activated receptor activityGO:000500710.6FGFR1, FGFR2, FGFR3
4phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:004693410.6FGFR1, FGFR2, FGFR3
5Ras guanyl-nucleotide exchange factor activityGO:00050889.8FGFR1, FGFR2, FGFR3
6protein homodimerization activityGO:00428039.1FGFR1, FGFR2, LRP4, NOG, TCF12, TWIST1
7protein bindingGO:00055154.2BHLHA9, EFNB1, FGFR1, FGFR2, FGFR3, FLNB

Sources for Synostosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet