Aliases & Classifications for Synostosis

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Aliases & Descriptions for Synostosis:

Name: Synostosis 11 13 48 37

Classifications:



External Ids:

Disease Ontology11 DOID:11971
MeSH37 D013580

Summaries for Synostosis

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Wikipedia:69 Synostosis (plural: synostoses) is fusion of two bones. It can be normal in puberty, fusion of the... more...

MalaCards based summary: Synostosis is related to antley-bixler syndrome without genital anomalies or disordered steroidogenesis and apert syndrome. An important gene associated with Synostosis is FLNB (Filamin B), and among its related pathways are Central carbon metabolism in cancer and VEGF Signaling. Affiliated tissues include bone, skin and bone marrow, and related mouse phenotypes are hearing/vestibular/ear and vision/eye.

Disease Ontology:11 A dysostosis that results in abnormal fusing of adjacent bones.

Related Diseases for Synostosis

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Diseases related to Synostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 173)
idRelated DiseaseScoreTop Affiliating Genes
1antley-bixler syndrome without genital anomalies or disordered steroidogenesis32.0FGFR1, FGFR2, FGFR3
2apert syndrome31.3FGFR2, FGFR3, RAB23
3spondylocarpotarsal synostosis syndrome12.2
4radioulnar synostosis with amegakaryocytic thrombocytopenia12.2
5congenital radio-ulnar synostosis12.1
6radioulnar synostosis12.1
7humeroradial synostosis12.0
8radioulnar synostosis with amegakaryocytic thrombocytopenia 211.9
9humeroradioulnar synostosis11.9
10lambdoid synostosis11.9
11tibio-fibular synostosis11.9
12humero-ulnar synostosis11.9
13radioulnar synostosis with microcephaly, short stature, scoliosis, and mental retardation11.8
14radioulnar synostosis, unilateral, with developmental retardation and hypotonia11.8
15coronal synostosis, syndactyly and jejunal atresia11.8
16radioulnar synostosis retinal pigment abnormalities11.8
17radio-ulnar synostosis type 211.8
18radio-ulnar synostosis type 111.8
19craniosynostosis-hydrocephalus-arnold-chiari malformation type i-radioulnar synostosis syndrome11.8
20cleft palate colobomata radial synostosis deafness11.7
21congenital heart disease radio ulnar synostosis mental retardation11.7
22synostosis of talus and calcaneus short stature11.7
23fgfr3-related isolated coronal synostosis11.7
24fgfr2-related isolated coronal synostosis11.7
25deafness-genital anomalies-metacarpal and metatarsal synostosis syndrome11.7
26humero-radial synostosis, unilateral11.7
27humero-radial synostosis, bilateral11.7
28humero-radio-ulnar synostosis, unilateral11.7
29humero-radio-ulnar synostosis, bilateral11.7
30radio-ulnar synostosis, unilateral11.7
31radio-ulnar synostosis, bilateral11.7
32humero-ulnar synostosis, unilateral11.7
33humero-ulnar synostosis, bilateral11.7
34antley-bixler syndrome11.5
35muenke syndrome11.5
36calcaneonavicular coalition11.2
37mesomelic dysplasia, kantaputra type11.1
38klippel-feil syndrome11.1
39jorgenson lenz syndrome11.0
40small patella syndrome11.0
41liebenberg syndrome10.9
42ramer ladda syndrome10.9
43syndactyly, type v10.7
44craniosynostosis 410.7
45nievergelt syndrome10.7
46multiple synostoses syndrome10.7
47allain-babin-demarquez syndrome10.7
48wisconsin syndrome10.7
49pfeiffer rockelein syndrome10.7
50samson gardner syndrome10.7

Graphical network of the top 20 diseases related to Synostosis:



Diseases related to synostosis

Symptoms for Synostosis

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Drugs & Therapeutics for Synostosis

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Drugs for Synostosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Tranexamic AcidPhase 4, Phase 32411197-18-85526
Synonyms:
08455_FLUKA
1197-17-7
1197-18-8
1ceb
3-14-00-00868 (Beilstein Handbook Reference)
4-(Aminomethyl)-Cyclohexanecarboxylic Acid
4-(Aminomethyl)cyclohexanecarboxylic acid
4-(aminomethyl)cyclohexane-1-carboxylic acid
857653_ALDRICH
A0236
AB00052260
AB1003647
AC-4687
AC1L1KJH
AC1Q50F3
AC1Q546D
AC1Q5U04
ALBB-006013
AMCA
AMCHA
AMH
AR-1F6595
Acide tranexamique
Acide tranexamique [INN-French]
Acido tranexamico
Acido tranexamico [INN-Spanish]
Acidum tranexamicum
Acidum tranexamicum [INN-Latin]
Amikapron
Amstat
Anvitoff
BAY 3517
BPBio1_000069
BRN 2207452
BSPBio_000061
BSPBio_002837
CAS-1197-18-8
CHEBI:48669
CHEMBL292500
CHEMBL877
CID5526
CL 65336
CL-65336
Carxamin
Cyclocapron
Cyklokapron
Cyklokapron (TN)
D01136
DB00302
DV 79
DV-79
DV79
DivK1c_000655
EINECS 214-818-2
Emorhalt
Exacyl
Frenolyse
HMS1568D03
HMS1921F08
HMS2092P03
HMS502A17
Hexapromin
Hexatron
I04-0993
IDI1_000655
KABI 2161
KBio1_000655
KBio2_001871
KBio2_004439
KBio2_007007
KBio3_002337
KBioGR_000511
 
KBioSS_001871
LS-56611
LS-56612
LT00159441
Mastop
MolPort-001-792-390
MolPort-002-512-008
NCGC00016569-01
NCGC00016569-02
NCGC00016569-03
NCGC00094944-01
NCGC00094944-02
NINDS_000655
NSC 291305
NSC291305
Oprea1_786414
Prestwick0_000171
Prestwick1_000171
Prestwick2_000171
Prestwick3_000171
Prestwick_476
RP 18,429
Rikavarin
Rikavarin (TN)
Rikavarin-S
SPBio_000689
SPBio_001982
SPECTRUM1502026
STK503668
STOCK1N-16183
Spectrum2_000655
Spectrum3_001189
Spectrum4_000046
Spectrum5_001258
Spectrum_001391
Spiramin
Tamcha
Tranex
Tranexamate
Tranexamic acid (JP15/USAN/INN)
Tranexamic acid [USAN:INN:BAN:JAN]
Tranexamic acid cis-form
Tranexamsaeure
Tranexan
Tranexmic acid
Tranhexamic acid
Trans AMCHA
Trans-1-(Aminomethyl)cyclohexane-4-carboxylic acid
Trans-4-(Aminomethyl)-1-cyclohexanecarboxylic acid
Trans-p-(Aminomethyl)cyclohexanecarboxylic
Transamin
Transamin (TN)
Transamlon
Trasamlon
UNII-6T84R30KC1
Ugurol
WLN: L6TJ AVQ D1Z -T
cis-4-(Aminomethyl)cyclohexanecarboxylic acid
cis-4-Aminomethylcyclohexane-1-carboxylic acid
cis-AMCHA
t-AMCHA
tranexamic acid
tranexmic acid
trans-1-Aminomethylcyclohexane-4-carboxylic acid
trans-4-(Aminomethyl)cyclohexane-1-carboxylic acid
trans-4-(Aminomethyl)cyclohexane-carboxylic acid
trans-4-(Aminomethyl)cyclohexanecarboxylic acid
trans-4-(Aminomethyl)cyclohexanecarboxylic acid ester
trans-4-Aminomethylcyclohexane-1-carboxylic acid
trans-4-aminomethylcyclohexane-1-carboxylic acid
trans-Amcha
trans-Tranexamic acid
trans-p-(Aminomethyl)cyclohexanecarboxylic acid
2
Aminocaproic AcidPhase 2, Phase 12660-32-2564
Synonyms:
.epsilon. S
.epsilon.-Aminocaproic acid
.epsilon.-Aminohexanoic acid
.epsilon.-Leucine
.epsilon.-Norleucine
.omega.-Aminocaproic acid
.omega.-Aminohexanoic acid
1319-82-0
177 J.D
177 J.D.
1cea
3kiv
6 Aminocaproic Acid
6 Aminohexanoic Acid
6-Amino-Hexanoate
6-Amino-Hexanoic acid
6-Amino-N-hexanoate
6-Amino-N-hexanoic acid
6-Amino-n-hexanoic acid
6-Aminocaproate
6-Aminocaproic acid
6-Aminohexanoate
6-Aminohexanoic acid
6-amino-hexanoic acid
6-amino-n-caproate
6-amino-n-caproic acid
6-aminohexanoate
6-aminohexanoic acid
60-32-2
87867-96-7
93208-38-9
A 7824
A0312
A2504_SIGMA
A7824_SIGMA
AB00051911
AC-035
AC1L19IP
AC1Q54EY
ACS
AI3-14512
AKOS000118734
AMICAR
AMINOCAPROIC
Acepramin
Acepramine
Acid, 6-Aminocaproic
Acid, 6-Aminohexanoic
Acid, epsilon-Aminocaproic
Acide aminocaproique
Acide aminocaproique [French]
Acide aminocaproique [INN-French]
Acide aminocaproque
Acide aminocaproïque
Acido aminocaproico
Acido aminocaproico [DCIT,Spanish]
Acido aminocaproico [INN-Spanish]
Acidum Aminocaproicum
Acidum aminocaproicum
Acidum aminocaproicum [INN-Latin]
Acidum aminocaproicum [Latin]
Acikaprin
Afibrin
Ahx
Amicar
Amicar (TN)
Amicar, |A-amino caproic acid, |A-Ahx, 6-aminohexanoic acid, Aminocaproic acid
Amikar
Aminocaproate
Aminocaproic
Aminocaproic Acid In Plastic Container
Aminocaproic Acids
Aminocaproic acid
Aminocaproic acid (USP)
Aminocaproic acid (USP/INN)
Aminocaproic acid [USAN:BAN:INN]
Aminocaproic acid [USAN:INN:BAN]
Aminocapronsäure
Aminohexanoic acid
Aminokapron
Atsemin
BIDD:GT0162
BPBio1_001056
BRN 0906872
BSPBio_000960
C02378
C3BDD377-8F43-4BEC-900A-D5850050BA82
C6H13NO2
CAS-60-32-2
CBDivE_004370
CCRIS 7706
CHEBI:16586
CHEMBL1046
CID564
CL 10304
CL-10304
CY 116
CY-116
CY116
Caplamin
Capracid
Capralense
Capramol
Capranol
Caproamin
Caprocid
Caprolisin
D00160
D015119
DB00513
DB04134
DivK1c_000551
EACA
EACS
EINECS 200-469-3
EPSILON-AMINOCAPROIC ACID
EU-0100082
Eaca
Eaca kabi
Epsamon
 
Epsicaprom
Epsicapron
Epsikapron
Epsilcapramin
Epsilcapramine
Epsillon-Aminocaproate
Epsillon-Aminocaproic acid
Epsillon-Aminocaproic acid' Epsilcapramin
Epsilon S
Epsilon-Aminocaproic Acid
Epsilon-Aminocapronsaeure
Epsilon-aminocapronzuur
H-6-Ahx-OH
H-EAhx-OH
H-epsilon-Acp-OH
HEXANOIC ACID,6-AMINO
HMS1570P22
HMS1920C07
HMS2091I07
HMS501L13
HSDB 3005
Hemocaprol
Hemopar
Hepin
IDI1_000551
InChI=1/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9
Ipsilon
JD 177
KBio1_000551
KBio2_000398
KBio2_002966
KBio2_005534
KBioGR_000586
KBioSS_000398
Kyselina omega-aminokapronova
Kyselina omega-aminokapronova [Czech]
LMFA01100035
LS-7191
Lopac-A-7824
Lopac0_000082
MLS001335991
MLS002695931
MolPort-001-779-881
NCGC00015092-01
NCGC00015092-02
NCGC00015092-03
NCGC00015092-07
NCGC00093587-01
NCGC00093587-02
NCGC00093587-03
NCGC00093587-04
NINDS_000551
NSC 26154
NSC 400230
NSC-26154
NSC212532
NSC26154
NSC400230
Omega-Aminocaproate
Omega-Aminocaproic acid
Omega-Aminohexanoate
Omega-Aminohexanoic acid
Prestwick0_000960
Prestwick1_000960
Prestwick2_000960
Prestwick3_000960
Respramin
S04-0132
S1671_Selleck
SMR000059162
SPBio_000202
SPBio_003109
SPECTRUM1500114
STK246894
Spectrum2_000131
Spectrum4_000143
Spectrum5_000780
Spectrum_000038
TL8003819
UNII-U6F3787206
WLN: Z5VQ
Z
acide aminocaproque
amicar
bmse000394
e-Amino-N-hexanoate
e-Amino-N-hexanoic acid
e-Aminocaproate
e-Aminocaproic acid
e-Aminocaproic acid USP
e-Aminohexanoate
e-Aminohexanoic acid
e-Leucine
e-Norleucine
epsilcapramine
epsilon Aminocaproic Acid
epsilon S
epsilon-Ahx
epsilon-Amino-N-hexanoate
epsilon-Amino-N-hexanoic acid
epsilon-Amino-n-caproic acid
epsilon-Amino-n-hexanoic acid
epsilon-Aminocaproate
epsilon-Aminocaproic acid
epsilon-Aminocaproic acid (JAN)
epsilon-Aminocaproic acid USP
epsilon-Aminohexanoate
epsilon-Aminohexanoic acid
epsilon-Leucine
epsilon-Norleucine
epsilon-S
epsilon-aminocaproate
nchembio.104-comp21
nchembio.2007.30-comp14
omega-Aminocaproic acid
omega-Aminohexanoic acid
w-Aminocaproate
w-Aminocaproic acid
w-Aminohexanoate
w-Aminohexanoic acid
Ácido aminocapróico
3
bilirubin107635-65-45280352
Synonyms:
(4Z,15Z)-Bilirubin IXa
(Z,Z)-Bilirubin IXa
1,10,19,22,23,24-Hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-Biline-8,12-dipropionate
1,10,19,22,23,24-Hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-Biline-8,12-dipropionic acid
2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8,12-dipropanoate
2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8,12-dipropanoic acid
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-((3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-3-yl)propanoate
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-((3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
 
3-(2-((3-(2-Carboxyethyl)-4-methyl-5-[(Z)-(3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-1H-pyrrol-2-yl)methyl)-4-methyl-5-[(Z)-(4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene
3-[2-[[3-(2-Carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate
3-[2-[[3-(2-Carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
3-[2-[[3-(2-Carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate
3-[2-[[3-(2-Carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
Bilirubin
Bilirubin IX-alpha
Cholerythrin
Hematoidin
4
Menthol21842216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol

Interventional clinical trials:

(show all 30)
idNameStatusNCT IDPhase
1The Efficacy and Population Pharmacokinetics of Tranexamic Acid for Craniosynostosis SurgeryRecruitingNCT02188576Phase 4
2Tranexamic Acid for Craniofacial SurgeryTerminatedNCT00722436Phase 4
3Comparison of a Bone Product to Bone Dust in Ossification of Small Calvarial Defects.WithdrawnNCT01006148Phase 4
4Blood Loss and Transfusion Requirement in Infants Treated With Tranexamic AcidRecruitingNCT01094977Phase 3
5A Trial to Evaluate the Safety, Local Tolerability, Pharmacokinetics and Pharmacodynamics of LDE225 on Skin Basal Cell Carcinomas in Gorlin Syndrome PatientsCompletedNCT00961896Phase 2
6Efficacy of Amicar for Children Having Craniofacial SurgeryRecruitingNCT02229968Phase 2
7Stem Cells and Tibial FracturesCompletedNCT00632034Phase 1
8Amicar Pharmacokinetics of Children Having Craniofacial SurgeryCompletedNCT00912119Phase 1
9Treatment of Displaced Lateral Clavicle Fractures Using a Locking Compression Plate With Lateral ExtensionCompletedNCT02256059
10Evaluation of Effects of Clavicular Hook Plate on Subacromial SpaceCompletedNCT01205763
11Effectiveness of Tortle Midliner Positioning System on the Prevention and Treatment of Cranial Molding Deformities in Preterm InfantsCompletedNCT02366936
12Qualitative and Quantitative Study Which Aims to Determine the Specifics of the Announcement for the Diagnosis of Patients With Craniosynostosis and Their Parents to Better Support Them in Their CareCompletedNCT02287805
13Effect of Tranexamic Acid Based on Pharmacokinetics in Pediatric Patients Undergoing Craniosynostosis Surgery: Randomized Controlled TrialCompletedNCT02180321
14Nautilus: Dynamic Craniotomy; New Surgical Technique and Preliminary ResultsCompletedNCT01672619
15Genetic Analysis of Craniosynostosis, Philadelphia TypeCompletedNCT00367796
16Child and Infant Learning ProjectCompletedNCT00077831
17MRI for Non-invasive Evaluation of Brain StressRecruitingNCT01898650
18Transtibial Amputation Outcomes StudyRecruitingNCT01821976
19Cancer in Inherited Bone Marrow Failure SyndromesRecruitingNCT00027274
20Treatment of Proximal Interphalangeal Joint Injuries. Clinical Efficiency of Syndactyly Treatment and Digital CompressionRecruitingNCT02548260
21Irradiated Blood Versus Non Irradiated Blood Transfusions in Craniosynostosis RepairRecruitingNCT02483702
22Osteogenic Profiling of Tissue From Children With CraniosynostosisRecruitingNCT00773643
23Clinical Study of Muenke Syndrome (FGFR3-Related Craniosynostosis)RecruitingNCT00106977
24Syndactyly Repair: Comparison of Skin Graft and No Skin Graft TechniquesActive, not recruitingNCT01416090
25National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular ConditionsActive, not recruitingNCT01322165
26Mononucleotide Autologous Stem Cells and Demineralized Bone Matrix in the Treatment of Non Union/Delayed FracturesNot yet recruitingNCT01435434
27The Effect of Gender on the Consumption of Pain Medication in Infants Undergoing Craniosynostosis Repair or Untethering of Cord in ITUNot yet recruitingNCT01996163
28Cranial Cup Use for the Prevention of Positional Head Shape Deformity in the NICUTerminatedNCT01218087
29Endoscopic Treatment for Isolated, Single Suture CraniosynostosisWithdrawnNCT00769847
30Hanger Helmet StudyWithdrawnNCT02561728

Search NIH Clinical Center for Synostosis


Cochrane evidence based reviews: synostosis

Genetic Tests for Synostosis

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Anatomical Context for Synostosis

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MalaCards organs/tissues related to Synostosis:

34
Bone, Skin, Bone marrow, Brain, Thyroid, Eye, Testes

Animal Models for Synostosis or affiliated genes

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MGI Mouse Phenotypes related to Synostosis:

39 (show all 17)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.8EFNB1, FGFR1, FGFR2, FGFR3, GLI3, GSC
2MP:00053918.3EFNB1, FGFR1, FGFR2, FGFR3, GLI3, GSC
3MP:00053678.0FGFR1, FGFR2, FGFR3, GLI3, GREM1, HOXA11
4MP:00053797.8EFNB1, FGFR1, FGFR2, GLI3, GSC, HOXA11
5MP:00053897.4EFNB1, FGFR1, FGFR2, FGFR3, GDF5, GLI3
6MP:00107717.4EFNB1, FGFR1, FGFR2, FGFR3, GLI3, GSC
7MP:00053867.4FGFR1, FGFR2, FGFR3, FLNB, GSC, LRP4
8MP:00053817.4EFNB1, FGFR1, FGFR2, FGFR3, GLI3, GSC
9MP:00053807.1EFNB1, FGFR1, FGFR2, GLI3, GREM1, GSC
10MP:00053826.5EFNB1, FGFR1, FGFR2, FGFR3, FLNB, GLI3
11MP:00036316.1EFNB1, FGFR1, FGFR2, FGFR3, FLNB, GLI3
12MP:00053886.0EFNB1, FGFR2, FGFR3, FLNB, GLI3, GREM1
13MP:00053845.8BHLHA9, EFNB1, FGFR1, FGFR2, FGFR3, FLNB
14MP:00053905.0EFNB1, FGFR1, FGFR2, FGFR3, FLNB, GDF5
15MP:00053714.5BHLHA9, EFNB1, FGFR1, FGFR2, FGFR3, FLNB
16MP:00053784.4EFNB1, FGFR1, FGFR2, FGFR3, FLNB, GDF5
17MP:00107684.1EFNB1, FGFR1, FGFR2, FGFR3, FLNB, GDF5

Publications for Synostosis

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Articles related to Synostosis:

(show top 50)    (show all 651)
idTitleAuthorsYear
1
Comparison of Intracranial Volume and Cephalic Index After Correction of Sagittal Synostosis With Spring-assisted Surgery or Pi-plasty. (26963298)
2016
2
The Management of Nonsyndromic, Isolated Sagittal Synostosis. (26825739)
2016
3
Perception of children's faces with unilateral coronal synostosis-an eye-tracking investigation. (26231563)
2015
4
Lambdoid Synostosis Versus Positional Posterior Plagiocephaly, a Comparison of Skull Base and Shape of Calvarium Using Computed Tomography Imaging. (26335322)
2015
5
Correction of hypotelorism in isolated metopic synostosis. (23848421)
2014
6
Isolated frontosphenoidal synostosis: a rare cause of synostotic frontal plagiocephaly. (24606403)
2014
7
Proximal radial diaphyseal segment resection for posttraumatic proximal radioulnar synostosis: a prospective study of 15 cases. (24768222)
2014
8
Post-traumatic humero-ulnar synostosis. (24732097)
2014
9
Congenital muscular torticollis concurrent with sagittal synostosis: a case report. (25379504)
2014
10
Improving ophthalmic outcomes in children with unilateral coronal synostosis by treatment with endoscopic strip craniectomy and helmet therapy rather than fronto-orbital advancement. (23791406)
2013
11
Delayed intracranial hypertension after cranial vault remodeling for nonsyndromic single-suture synostosis. (23581636)
2013
12
The utilization of a suture bridge construct for tibiofibular instability during transtibial amputation without distal bridge synostosis creation. (23429174)
2013
13
Magnetic resonance imaging in isolated sagittal synostosis. (22801186)
2012
14
A family with radio-ulnar synostosis, scoliosis, and thick vermilion of lips: a novel syndrome or variant of GiuffrA"-Tsukahara syndrome? (22786695)
2012
15
Preoperative and postoperative developmental attainment in patients with sagittal synostosis: 5-year follow-up. (21284455)
2011
16
Proximal tibiofibular synostosis as a possible cause of a pseudoradicular syndrome: a case report. (21222100)
2011
17
Facial suture synostosis of newborn Fgfr1(P250R/+) and Fgfr2(S252W/+) mouse models of Pfeiffer and Apert syndromes. (21538817)
2011
18
Combined metopic and sagittal craniosynostosis: is it worse than sagittal synostosis alone? (21806341)
2011
19
Proximal radio-ulnar synostosis with bone marrow failure syndrome in an infant without a HOXA11 mutation. (20562651)
2010
20
Bilateral lambdoid and sagittal synostosis (BLSS): a unique craniosynostosis syndrome or predictable craniofacial phenotype? (19396832)
2009
21
Proximal radio-ulnar synostosis and nonunion after olecranon fracture tension-band wiring: a case report. (19393921)
2009
22
Cranial expansion with distraction osteogenesis for multiple-suture synostosis in school-aged children. (19326488)
2009
23
Referral pattern and surgical outcome of sagittal synostosis. (18329351)
2009
24
Unilateral radio-ulnar synostosis and idic-Y chromosome. (19239087)
2008
25
Isolated congenital pseudoarthrosis of the fibula: a comparison of fibular osteosynthesis with distal tibiofibular synostosis. (19034172)
2008
26
Detection of important venous collaterals by computed tomography venogram in multisutural synostosis. Case report and review of the literature. (18154023)
2007
27
Zygomaticotemporal synostosis: a rare cause of progressive facial asymmetry. (17214532)
2007
28
Sagittal synostosis in X-linked hypophosphatemic rickets and related diseases. (17551721)
2007
29
Craniofacial anomalies, humero-radial synostosis, rhizomelic limb shortness: previously unrecognized autosomal recessive syndrome. (17304553)
2007
30
Frontosphenoidal synostosis: a rare cause of unilateral anterior plagiocephaly. (17891404)
2007
31
Immediate correction of sagittal synostosis, 1978. (18459911)
2007
32
3D visualization and simulation of frontoorbital advancement in metopic synostosis. (17701413)
2007
33
Undiagnosed obstructive sleep apnea syndrome in children with syndromal craniofacial synostosis. (15213550)
2004
34
Bilateral aplasia of the thumb, proximal radioulnar synostosis and unilateral synostosis of metacarpals 4 and 5. (15083702)
2004
35
Clinical outcome of the modified pi-plasty procedure for sagittal synostosis. (11358093)
2001
36
Management of radioulnar synostosis with mobilization, anconeus interposition, and a forearm rotation assist splint. (10633900)
1999
37
The Antley-Bixler syndrome. A new case without radiohumeral synostosis. (9664207)
1998
38
Mobilization of a congenital proximal radioulnar synostosis with use of a free vascularized fascio-fat graft. (9730128)
1998
39
Osteoblast-directed osteoclast metabolism from patients with premature coronal synostosis. (9145118)
1997
40
Preoperative anthropometric dysmorphology in metopic synostosis. (9261497)
1997
41
Congenital metacarpal synostosis treated by longitudinal osteotomy and placement of a silicone wedge. (9483426)
1997
42
Stability of fronto-orbital advancement in nonsyndromic bilateral coronal synostosis: a quantitative three-dimensional computed tomographic study. (8700973)
1996
43
Genetic nosology and counseling of humeroradial synostosis. (7811427)
1994
44
Treatment of posttraumatic radioulnar synostosis with excision and low-dose radiation. (8349985)
1993
45
Radiohumeral synostosis, femoral bowing, other skeletal anomalies and anal atresia, a variant example of Antley-Bixler syndrome? (8267929)
1993
46
Sagittal synostosis: quantitative assessment of presenting deformity and surgical results based on CT scans. (8234497)
1993
47
Treatment of functional lambdoid synostosis. (1821312)
1991
48
Humeroradioulnar synostosis appearing as distal humeral bifurcation in a patient with distal phocomelia of the upper limbs and radial ectrodactyly. (6465206)
1984
49
Radioulnar synostosis and craniosynostosis in one family. (4768942)
1973
50
Phocomelia with radioulnar synostosis. Report of a case with review of the literature. (5937586)
1966

Variations for Synostosis

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Expression for genes affiliated with Synostosis

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Search GEO for disease gene expression data for Synostosis.

Pathways for genes affiliated with Synostosis

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GO Terms for genes affiliated with Synostosis

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Biological processes related to Synostosis according to GeneCards Suite gene sharing:

(show all 47)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:003560710.8FGFR1, FGFR2
2outer ear morphogenesisGO:004247310.7FGFR1, TWIST1
3embryonic digestive tract morphogenesisGO:004855710.7FGFR2, GLI3
4organ inductionGO:000175910.7FGFR1, HOXA11
5embryonic skeletal joint morphogenesisGO:006027210.6HOXA11, NOG
6branching involved in salivary gland morphogenesisGO:006044510.6FGFR1, FGFR2
7hindlimb morphogenesisGO:003513710.6GDF5, TWIST1
8ventricular zone neuroblast divisionGO:002184710.5FGFR1, FGFR2
9anatomical structure developmentGO:004885610.5GLI3, LRP4
10phosphatidylinositol-3-phosphate biosynthetic processGO:003609210.5FGFR1, FGFR2, FGFR3
11phosphatidylinositol phosphorylationGO:004685410.4FGFR1, FGFR2, FGFR3
12regulation of phosphatidylinositol 3-kinase signalingGO:001406610.4FGFR1, FGFR2, FGFR3
13mesenchymal cell differentiationGO:004876210.4FGFR1, FGFR2, NOG
14phosphatidylinositol-mediated signalingGO:004801510.4FGFR1, FGFR2, FGFR3
15negative regulation of osteoblast differentiationGO:004566810.4FGFR1, NOG, TWIST1
16fibroblast growth factor receptor signaling pathwayGO:000854310.4FGFR1, FGFR2, FGFR3
17positive regulation of phospholipase activityGO:001051810.4FGFR1, FGFR2, FGFR3
18positive regulation of chondrocyte differentiationGO:003233210.3GDF5, GLI3, HOXA11
19ureteric bud developmentGO:000165710.2FGFR1, FGFR2, NOG
20positive regulation of MAPK cascadeGO:004341010.2FGFR1, FGFR2, FGFR3
21lung developmentGO:003032410.2FGFR1, FGFR2, GLI3
22chondrocyte differentiationGO:000206210.2FGFR1, FGFR3, GDF5
23middle ear morphogenesisGO:004247410.2FGFR1, GSC, NOG
24ureteric bud formationGO:006067610.1GREM1, NOG
25positive regulation of epithelial cell proliferationGO:005067910.1FGFR2, NOG, TWIST1
26positive regulation of branching involved in ureteric bud morphogenesisGO:009019010.1GREM1, NOG
27lung-associated mesenchyme developmentGO:006048410.0FGFR1, FGFR2
28negative regulation of osteoblast proliferationGO:003368910.0GREM1, NELL1
29orbitofrontal cortex developmentGO:00217699.9FGFR1, FGFR2
30skeletal system developmentGO:00015019.9FGFR1, FGFR3, HOXA11, NOG
31negative regulation of pathway-restricted SMAD protein phosphorylationGO:00603949.9GREM1, NOG
32negative regulation of chondrocyte differentiationGO:00323319.8GDF5, GREM1
33in utero embryonic developmentGO:00017019.8FGFR1, FGFR2, GLI3, NOG, TWIST1
34regulation of gene expressionGO:00104689.7FGFR1, GLI3, HOXA11, NELL1
35embryonic digit morphogenesisGO:00427339.7GLI3, HOXA11, LRP4, NOG, TWIST1
36positive regulation of neuron differentiationGO:00456669.7FGFR1, GDF5, TCF12
37branching involved in ureteric bud morphogenesisGO:00016589.6GLI3, GREM1, HOXA11
38embryonic skeletal system morphogenesisGO:00487049.5GLI3, GSC, TWIST1
39dorsal/ventral pattern formationGO:00099539.5GLI3, HOXA11, LRP4, NOG
40limb developmentGO:00601739.3GLI3, GREM1, LRP4, NOG
41proximal/distal pattern formationGO:00099549.2GLI3, GREM1, HOXA11, LRP4
42cell-cell signalingGO:00072679.1EFNB1, FGFR2, FGFR3, GDF5, GREM1
43negative regulation of canonical Wnt signaling pathwayGO:00900909.0GLI3, GREM1, LRP4, NOG
44positive regulation of transcription, DNA-templatedGO:00458938.8GLI3, GREM1, HOXA11, MECOM, TCF12
45negative regulation of transcription, DNA-templatedGO:00458928.6GLI3, GREM1, MECOM, TBX22, TWIST1
46embryonic limb morphogenesisGO:00303268.3FGFR1, GDF5, GLI3, GREM1, HOXA11, LRP4
47negative regulation of transcription from RNA polymerase II promoterGO:00001228.2FGFR1, FGFR2, GLI3, GSC, NOG, TBX22

Molecular functions related to Synostosis according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:000500710.6FGFR1, FGFR2, FGFR3
21-phosphatidylinositol-3-kinase activityGO:001630310.5FGFR1, FGFR2, FGFR3
3phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:004693410.5FGFR1, FGFR2, FGFR3
4fibroblast growth factor bindingGO:001713410.4FGFR1, FGFR2, FGFR3
5Ras guanyl-nucleotide exchange factor activityGO:000508810.4FGFR1, FGFR2, FGFR3
6BMP bindingGO:003612210.0GDF5, GREM1
7protein homodimerization activityGO:00428038.9FGFR1, FGFR2, LRP4, NOG, TCF12, TWIST1
8protein bindingGO:00055153.5BHLHA9, EFNB1, FGFR1, FGFR2, FGFR3, FLNB

Sources for Synostosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet