Aliases & Classifications for Synostosis

Aliases & Descriptions for Synostosis:

Name: Synostosis 12 52 42 14

Classifications:



External Ids:

Disease Ontology 12 DOID:11971
MeSH 42 D013580
UMLS 69 C0039093

Summaries for Synostosis

Disease Ontology : 12 A dysostosis that results_in abnormal fusing of adjacent bones.

MalaCards based summary : Synostosis is related to antley-bixler syndrome without genital anomalies or disordered steroidogenesis and apert syndrome. An important gene associated with Synostosis is HOXA11 (Homeobox A11), and among its related pathways/superpathways are MAPK signaling pathway and mTOR signaling pathway (KEGG). The drugs Tranexamic Acid and Antifibrinolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and bone marrow, and related phenotypes are growth/size/body region and limbs/digits/tail

Wikipedia : 71 Synostosis (plural: synostoses) is fusion of two bones. It can be normal in puberty, fusion of the... more...

Related Diseases for Synostosis

Diseases related to Synostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
id Related Disease Score Top Affiliating Genes
1 antley-bixler syndrome without genital anomalies or disordered steroidogenesis 32.2 FGFR2 FGFR3 RAB23
2 apert syndrome 31.6 FGFR1 FGFR2 FGFR3 MSX2
3 isolated scaphocephaly 31.2 FGFR3 TCF12 TWIST1
4 spondylocarpotarsal synostosis syndrome 12.2
5 radioulnar synostosis 12.2
6 radioulnar synostosis with amegakaryocytic thrombocytopenia 12.1
7 congenital radio-ulnar synostosis 12.1
8 radioulnar synostosis with amegakaryocytic thrombocytopenia 2 11.9
9 humeroradial synostosis 11.8
10 humeroradioulnar synostosis 11.8
11 lambdoid synostosis 11.8
12 tibio-fibular synostosis 11.7
13 humero-ulnar synostosis 11.7
14 radioulnar synostosis with microcephaly, short stature, scoliosis, and mental retardation 11.7
15 radio-ulnar synostosis type 1 11.7
16 radio-ulnar synostosis type 2 11.7
17 coronal synostosis, syndactyly and jejunal atresia 11.7
18 radioulnar synostosis, unilateral, with developmental retardation and hypotonia 11.7
19 craniosynostosis-hydrocephalus-arnold-chiari malformation type i-radioulnar synostosis syndrome 11.7
20 muenke syndrome 11.6
21 deafness-genital anomalies-metacarpal and metatarsal synostosis syndrome 11.6
22 cleft palate colobomata radial synostosis deafness 11.6
23 congenital heart disease radio ulnar synostosis mental retardation 11.6
24 humero-radial synostosis, unilateral 11.6
25 humero-radial synostosis, bilateral 11.6
26 humero-radio-ulnar synostosis, unilateral 11.6
27 synostosis of talus and calcaneus short stature 11.6
28 humero-radio-ulnar synostosis, bilateral 11.6
29 radio-ulnar synostosis, unilateral 11.6
30 radio-ulnar synostosis, bilateral 11.6
31 fgfr3-related isolated coronal synostosis 11.6
32 humero-ulnar synostosis, unilateral 11.6
33 fgfr2-related isolated coronal synostosis 11.6
34 humero-ulnar synostosis, bilateral 11.6
35 antley-bixler syndrome 11.6
36 calcaneonavicular coalition 11.3
37 mesomelic dysplasia, kantaputra type 11.2
38 craniosynostosis 11.1
39 syndactyly 11.0
40 saethre-chotzen syndrome 11.0
41 craniofrontonasal dysplasia 11.0
42 3mc syndrome 11.0
43 klippel-feil syndrome 10.9
44 jorgenson lenz syndrome 10.9
45 liebenberg syndrome 10.8
46 small patella syndrome 10.8
47 carpenter syndrome 10.8
48 acrofacial dysostosis 1, nager type 10.8
49 syndactyly, mesoaxial synostotic, with phalangeal reduction 10.8
50 osebold-remondini syndrome 10.8

Graphical network of the top 20 diseases related to Synostosis:



Diseases related to Synostosis

Symptoms & Phenotypes for Synostosis

MGI Mouse Phenotypes related to Synostosis:

44 (show all 20)
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.43 EFNB1 FGFR1 FGFR2 LRP4 MECOM MSX2
2 limbs/digits/tail MP:0005371 10.43 FGFR3 FLNB GDF5 GLI3 GSC HOXA11
3 mortality/aging MP:0010768 10.43 EFNB1 FGFR1 FGFR2 FGFR3 FLNB GDF5
4 craniofacial MP:0005382 10.41 EFNB1 FGFR1 FGFR2 FGFR3 FLNB GLI3
5 behavior/neurological MP:0005386 10.4 TWIST1 WNT7A FGFR1 FGFR2 FGFR3 FLNB
6 cellular MP:0005384 10.39 BHLHA9 EFNB1 FGFR1 FGFR2 FGFR3 FLNB
7 embryo MP:0005380 10.36 EFNB1 FGFR1 FGFR2 GLI3 GSC LRP4
8 cardiovascular system MP:0005385 10.32 FGFR1 FGFR2 FLNB GLI3 GSC MECOM
9 nervous system MP:0003631 10.31 MSX2 NOG RAB23 SALL4 TCF12 TWIST1
10 endocrine/exocrine gland MP:0005379 10.28 EFNB1 FGFR1 FGFR2 GLI3 GSC HOXA11
11 integument MP:0010771 10.27 EFNB1 FGFR1 FGFR2 FGFR3 GLI3 GSC
12 digestive/alimentary MP:0005381 10.26 FGFR3 GLI3 GSC MSX2 NOG SALL4
13 hearing/vestibular/ear MP:0005377 10.25 EFNB1 FGFR1 FGFR2 FGFR3 GLI3 GSC
14 reproductive system MP:0005389 10.03 EFNB1 FGFR1 FGFR2 FGFR3 GDF5 GLI3
15 muscle MP:0005369 9.98 FGFR1 FGFR2 GSC MECOM MSX2 NOG
16 normal MP:0002873 9.97 FGFR1 FGFR2 FGFR3 GLI3 MECOM MSX2
17 renal/urinary system MP:0005367 9.92 FGFR3 GLI3 HOXA11 LRP4 NOG SALL4
18 skeleton MP:0005390 9.91 RAB23 SALL4 TWIST1 WNT7A EFNB1 FGFR1
19 respiratory system MP:0005388 9.85 EFNB1 FGFR2 FGFR3 FLNB GLI3 GSC
20 vision/eye MP:0005391 9.36 RAB23 SALL4 WNT7A EFNB1 FGFR1 FGFR2

Drugs & Therapeutics for Synostosis

Drugs for Synostosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 4,Phase 3 1197-18-8 5526
2 Antifibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1
3 Coagulants Phase 4,Phase 3,Phase 2,Phase 1
4 Hemostatics Phase 4,Phase 3,Phase 2,Phase 1
5
Aminocaproic Acid Approved, Investigational Phase 2,Phase 1 60-32-2 564
6
Menthol Approved 2216-51-5 16666
7 Analgesics
8 Peripheral Nervous System Agents
9
Bilirubin 635-65-4 5280352
10 Calcium, Dietary
11 Calamus Nutraceutical

Interventional clinical trials:

(show all 33)
id Name Status NCT ID Phase
1 The Efficacy and Population Pharmacokinetics of Tranexamic Acid for Craniosynostosis Surgery Recruiting NCT02188576 Phase 4
2 Tranexamic Acid for Craniofacial Surgery Terminated NCT00722436 Phase 4
3 Comparison of a Bone Product to Bone Dust in Ossification of Small Calvarial Defects. Withdrawn NCT01006148 Phase 4
4 Blood Loss and Transfusion Requirement in Infants Treated With Tranexamic Acid Unknown status NCT01094977 Phase 3
5 A Trial to Evaluate the Safety, Local Tolerability, Pharmacokinetics and Pharmacodynamics of LDE225 on Skin Basal Cell Carcinomas in Gorlin Syndrome Patients Completed NCT00961896 Phase 2
6 Efficacy of Amicar for Children Having Craniofacial Surgery Recruiting NCT02229968 Phase 2
7 Stem Cells and Tibial Fractures Completed NCT00632034 Phase 1
8 Amicar Pharmacokinetics of Children Having Craniofacial Surgery Completed NCT00912119 Phase 1
9 Mononucleotide Autologous Stem Cells and Demineralized Bone Matrix in the Treatment of Non Union/Delayed Fractures Unknown status NCT01435434
10 The Effect of Gender on the Consumption of Pain Medication in Infants Undergoing Craniosynostosis Repair or Untethering of Cord in ITU Unknown status NCT01996163
11 Treatment of Displaced Lateral Clavicle Fractures Using a Locking Compression Plate With Lateral Extension Completed NCT02256059
12 Evaluation of Effects of Clavicular Hook Plate on Subacromial Space Completed NCT01205763
13 Qualitative and Quantitative Study Which Aims to Determine the Specifics of the Announcement for the Diagnosis of Patients With Craniosynostosis and Their Parents to Better Support Them in Their Care Completed NCT02287805
14 Effect of Tranexamic Acid Based on Pharmacokinetics in Pediatric Patients Undergoing Craniosynostosis Surgery: Randomized Controlled Trial Completed NCT02180321
15 Nautilus: Dynamic Craniotomy; New Surgical Technique and Preliminary Results Completed NCT01672619
16 Genetic Analysis of Craniosynostosis, Philadelphia Type Completed NCT00367796
17 Child and Infant Learning Project Completed NCT00077831
18 Treatment of Cranial Molding Deformities in Preterm Infants Completed NCT02366936
19 National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions Completed NCT01322165
20 Transtibial Amputation Outcomes Study Recruiting NCT01821976
21 Network Of Clinical Research Studies On Craniosynostosis, Skull Malformations With Premature Fusion Of Skull Bones Recruiting NCT03025763
22 Cancer in Inherited Bone Marrow Failure Syndromes Recruiting NCT00027274
23 MRI for Non-invasive Evaluation of Brain Stress Recruiting NCT01898650
24 Optic Nerve Sheath Diameter in Craniosynostosis Recruiting NCT03131245
25 Treatment of Proximal Interphalangeal Joint Injuries. Clinical Efficiency of Syndactyly Treatment and Digital Compression Recruiting NCT02548260
26 Osteogenic Profiling of Tissue From Children With Craniosynostosis Recruiting NCT00773643
27 Clinical Study of Muenke Syndrome (FGFR3-Related Craniosynostosis) Recruiting NCT00106977
28 Irradiated Blood Versus Non Irradiated Blood Transfusions in Craniosynostosis Repair Recruiting NCT02483702
29 Syndactyly Repair: Comparison of Skin Graft and No Skin Graft Techniques Active, not recruiting NCT01416090
30 Comparison of Scar Formation in Syndactyly Release Surgery With Full Thickness Skin Graft Versus Skin Graft Substitute Not yet recruiting NCT03107546
31 Cranial Cup Use for the Prevention of Positional Head Shape Deformity in the NICU Terminated NCT01218087
32 Endoscopic Treatment for Isolated, Single Suture Craniosynostosis Withdrawn NCT00769847
33 Hanger Helmet Study Withdrawn NCT02561728

Search NIH Clinical Center for Synostosis

Cochrane evidence based reviews: synostosis

Genetic Tests for Synostosis

Anatomical Context for Synostosis

MalaCards organs/tissues related to Synostosis:

39
Bone, Eye, Bone Marrow, Thyroid, Brain, Testes

Publications for Synostosis

Articles related to Synostosis:

(show top 50) (show all 659)
id Title Authors Year
1
Squamous Suture Synostosis: A Review With Emphasis on Cranial Morphology and Involvement of Other Cranial Sutures. ( 27831981 )
2017
2
Filamin B Loss-of-Function Mutation in Dimerization Domain Causes Autosomal-Recessive Spondylocarpotarsal Synostosis Syndrome with Rib Anomalies. ( 28145000 )
2017
3
Treated Unilateral Lambdoid Synostosis Using Cranium Distraction Osteogenesis With Z-shaped Osteotomy. ( 28059851 )
2017
4
Capitate-trapezoid synostosis: Analysis of an early bronze age case and review of the literature. ( 27813627 )
2016
5
Surgical Treatment of Posttraumatic Radioulnar Synostosis. ( 26977328 )
2016
6
Protein-altering MYH3 variants are associated with a spectrum of phenotypes extending to spondylocarpotarsal synostosis syndrome. ( 27381093 )
2016
7
Anthropometric Outcomes following Fronto-Orbital Advancement for Metopic Synostosis. ( 27119926 )
2016
8
Concurrent occurrence of an inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving MAP2K2 in a patient with developmental delay, distinctive facial features, and lambdoid synostosis. ( 27751966 )
2016
9
Perinatal features and rate of cesarean section in newborns with non-syndromic sagittal synostosis. ( 27060068 )
2016
10
Isolated Unilateral Frontosphenoidal Suture Synostosis in Six Patients: Lessons Learned in Diagnosis and Treatment. ( 27152571 )
2016
11
Quantifying Craniometric Change Early After Fronto-Orbital Advancement in Metopic Synostosis. ( 27513770 )
2016
12
Thoracoscopic Resection of a Symptomatic, Congenital Rib Synostosis. ( 27000588 )
2016
13
The metopic index: an anthropometric index for the quantitative assessment of trigonocephaly from metopic synostosis. ( 27153376 )
2016
14
Combat-related bridge synostosis versus traditional transtibial amputation: comparison of military-specific outcomes. ( 26644067 )
2016
15
The Significance of Squamosal Suture Synostosis. ( 27438438 )
2016
16
Internal Distraction Osteogenesis With Piezosurgery Oblique Osteotomy of Supraorbital Margin of Frontal Bone for the Treatment of Unilateral Coronal Synostosis. ( 27845963 )
2016
17
Long-term results after a free vascularized adipofascial graft for congenital proximal radioulnar synostosis with an average follow-up of 10 years: a series of four cases. ( 27422459 )
2016
18
Endoscope-assisted management of sagittal synostosis: wide vertex suturectomy and barrel stave osteotomies versus narrow vertex suturectomy. ( 27611899 )
2016
19
Monozygotic twins presenting with isolated sagittal and bicoronal synostosis, respectively. ( 26925815 )
2016
20
Photometric evaluation of cranial and facial symmetry in hemicoronal single suture synostosis treated with surgical fronto-orbital remodeling. ( 27288326 )
2016
21
A new quantitative image-based method for evaluation of bony temporal hollowing in metopic synostosis. ( 27125314 )
2016
22
Objective Assessment of the Interfrontal Angle for Severity Grading and Operative Decision-Making in Metopic Synostosis. ( 27119927 )
2016
23
Cerebrospinal fluid collections in sagittal suture synostosis. ( 26767840 )
2016
24
Minimally Invasive Strip Craniectomy Simplifies Anesthesia Practice in Patients With Isolated Sagittal Synostosis. ( 27579560 )
2016
25
Symptomatic Rhizarthritis in a Bilateral Scaphotrapezial Synostosis. ( 27616832 )
2016
26
Diaphyseal tibiofibular synostosis in professional athletes: Report of 2 cases. ( 26615768 )
2016
27
Distal tibiofibular synostosis after surgically resolved ankle fractures: An epidemiological, clinical and morphological evaluation of a patient sample. ( 27645618 )
2016
28
The Management of Nonsyndromic, Isolated Sagittal Synostosis. ( 26825739 )
2016
29
Plagiocephaly due to Frontosphenoidal Suture Synostosis: Report of 2 Cases and Literature Review. ( 26960206 )
2016
30
Stepwise Removal of The Fused Midline Parietal Bone to Avoid Superior Sagittal Sinus Injury in Infants with Sagital Synostosis. ( 27593802 )
2016
31
Minimally Invasive Strip Craniectomy Simplifies Anesthesia Practice in Patients With Isolated Sagittal Synostosis. ( 28005739 )
2016
32
Volume measurements on three-dimensional photogrammetry after extended strip versus total cranial remodeling for sagittal synostosis: A comparative cohort study. ( 27591089 )
2016
33
Surgical correction of lambdoid synostosis - New technique and first results. ( 27595190 )
2016
34
Unilateral coronal synostosis: can we trust the sagittal suture as a landmark for the underlying superior sagittal sinus? ( 26745648 )
2016
35
Comparison of Intracranial Volume and Cephalic Index After Correction of Sagittal Synostosis With Spring-assisted Surgery or Pi-plasty. ( 26963298 )
2016
36
Synostosis of proximal phalangeal bases for loss of distal metacarpal. ( 27904227 )
2016
37
Minimally invasive single-session double-level rotational osteotomy of the forearm bones to correct fixed pronation deformity in congenital proximal radioulnar synostosis. ( 27312798 )
2016
38
Rescue of Premature Coronal Suture Fusion With TGF-I^2 Neutralizing Antibody in Rabbits With Delayed-Onset Synostosis. ( 27505182 )
2016
39
Frontobiparietal remodeling with or without a widening bridge for sagittal synostosis: comparison of 2 cohorts for aesthetic and functional outcome. ( 25910033 )
2015
40
Mutations in MECOM, Encoding Oncoprotein EVI1, Cause Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia. ( 26581901 )
2015
41
An atypical 0.73 MB microduplication of 22q11.21 and a novel SALL4 missense mutation associated with thumb agenesis and radioulnar synostosis. ( 25823593 )
2015
42
Perception of children's faces with unilateral coronal synostosis-an eye-tracking investigation. ( 26231563 )
2015
43
Surgical Considerations for Massive Tarsal Coalitions in Multiple Synostosis Syndrome: A Case Report. ( 25799911 )
2015
44
Morphological, functional and neurological outcomes of craniectomy versus cranial vault remodeling for isolated nonsyndromic synostosis of the sagittal suture: a systematic review. ( 26470674 )
2015
45
New Pattern of Sutural Synostosis Associated With TWIST Gene Mutation and Saethre-Chotzen Syndrome: Peace Sign Synostosis. ( 26114524 )
2015
46
Facial Asymmetry in Children with Unicoronal Synostosis Who Have Undergone Craniofacial Reconstruction in Infancy. ( 26418148 )
2015
47
Spring-assisted surgery in the treatment of sagittal synostosis: A systematic review. ( 25676430 )
2015
48
Effects of open and endoscopic surgery on skull growth and calvarial vault volumes in sagittal synostosis. ( 25569396 )
2015
49
Malpositioned olecranon fracture tension-band wiring results in proximal radioulnar synostosis. ( 26514829 )
2015
50
Secondary Cranial Vault Remodeling for Restenosis after Primary Sagittal Synostosis Repair. ( 25832724 )
2015

Variations for Synostosis

Expression for Synostosis

Search GEO for disease gene expression data for Synostosis.

Pathways for Synostosis

GO Terms for Synostosis

Cellular components related to Synostosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.5 BHLHA9 EFNB1 FGFR1 FGFR2 FGFR3 FLNB

Biological processes related to Synostosis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
id Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.98 FGFR1 GLI3 HOXA11 NELL1
2 multicellular organism development GO:0007275 9.97 BHLHA9 EFNB1 FLNB GSC HOXA11 LRP4
3 skeletal system development GO:0001501 9.93 FGFR1 FGFR3 HOXA11 NOG
4 phosphatidylinositol-mediated signaling GO:0048015 9.91 FGFR1 FGFR2 FGFR3
5 osteoblast differentiation GO:0001649 9.91 MSX2 NOG TWIST1
6 phosphatidylinositol phosphorylation GO:0046854 9.9 FGFR1 FGFR2 FGFR3
7 muscle organ development GO:0007517 9.9 FLNB TCF12 TWIST1
8 lung development GO:0030324 9.89 FGFR1 FGFR2 GLI3
9 anterior/posterior pattern specification GO:0009952 9.89 GLI3 HOXA11 MSX2
10 BMP signaling pathway GO:0030509 9.89 LRP4 MSX2 NOG
11 positive regulation of neuron differentiation GO:0045666 9.89 FGFR1 GDF5 TCF12
12 positive regulation of MAPK cascade GO:0043410 9.89 FGFR1 FGFR2 FGFR3
13 palate development GO:0060021 9.88 GLI3 TWIST1 WNT7A
14 fibroblast growth factor receptor signaling pathway GO:0008543 9.88 FGFR1 FGFR2 FGFR3
15 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.88 FGFR1 FGFR2 FGFR3
16 in utero embryonic development GO:0001701 9.88 FGFR1 FGFR2 GLI3 NOG SALL4 TWIST1
17 neural tube closure GO:0001843 9.87 NOG SALL4 TWIST1
18 somatic stem cell population maintenance GO:0035019 9.85 NOG SALL4 WNT7A
19 positive regulation of epithelial cell proliferation GO:0050679 9.85 FGFR2 NOG TWIST1
20 negative regulation of cell differentiation GO:0045596 9.85 GLI3 NOG TWIST1
21 cartilage development GO:0051216 9.85 GDF5 MSX2 NOG WNT7A
22 positive regulation of osteoblast differentiation GO:0045669 9.84 GLI3 MSX2 NELL1
23 embryonic skeletal system morphogenesis GO:0048704 9.82 GLI3 GSC TWIST1
24 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.82 FGFR1 FGFR2 FGFR3
25 neural tube development GO:0021915 9.81 GLI3 NOG SALL4
26 ureteric bud development GO:0001657 9.8 FGFR1 FGFR2 NOG
27 odontogenesis GO:0042476 9.79 FGFR2 MSX2 TWIST1
28 chondrocyte differentiation GO:0002062 9.78 FGFR1 FGFR3 GDF5 WNT7A
29 bone morphogenesis GO:0060349 9.77 FGFR2 FGFR3 MSX2
30 embryonic hindlimb morphogenesis GO:0035116 9.77 MSX2 TWIST1 WNT7A
31 wound healing GO:0042060 9.77 FGFR2 GLI3 MSX2 NOG WNT7A
32 limb development GO:0060173 9.76 GLI3 LRP4 NOG WNT7A
33 proximal/distal pattern formation GO:0009954 9.75 GLI3 HOXA11 LRP4
34 middle ear morphogenesis GO:0042474 9.74 FGFR1 GSC NOG
35 anatomical structure formation involved in morphogenesis GO:0048646 9.73 GLI3 NOG
36 endocardial cushion morphogenesis GO:0003203 9.73 NOG TWIST1
37 uterus development GO:0060065 9.73 HOXA11 WNT7A
38 anatomical structure development GO:0048856 9.73 GLI3 LRP4
39 positive regulation of chondrocyte differentiation GO:0032332 9.73 GDF5 GLI3 HOXA11
40 branching involved in salivary gland morphogenesis GO:0060445 9.71 FGFR1 FGFR2
41 hindlimb morphogenesis GO:0035137 9.7 GDF5 TWIST1
42 mesenchymal cell differentiation GO:0048762 9.7 FGFR1 FGFR2 NOG
43 organ induction GO:0001759 9.69 FGFR1 HOXA11
44 embryonic skeletal joint morphogenesis GO:0060272 9.69 HOXA11 NOG
45 lung-associated mesenchyme development GO:0060484 9.69 FGFR1 FGFR2
46 membranous septum morphogenesis GO:0003149 9.68 FGFR2 NOG
47 outer ear morphogenesis GO:0042473 9.68 FGFR1 TWIST1
48 positive regulation of phospholipase activity GO:0010518 9.67 FGFR1 FGFR2 FGFR3
49 BMP signaling pathway involved in heart development GO:0061312 9.65 MSX2 NOG
50 cranial suture morphogenesis GO:0060363 9.65 MSX2 TWIST1

Molecular functions related to Synostosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.88 FGFR1 FGFR2 LRP4 NOG TCF12 TWIST1
2 sequence-specific DNA binding GO:0043565 9.85 GLI3 GSC HOXA11 MSX2 SALL4
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.54 FGFR1 FGFR2 FGFR3
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.5 FGFR1 FGFR2 FGFR3
5 1-phosphatidylinositol-3-kinase activity GO:0016303 9.43 FGFR1 FGFR2 FGFR3
6 fibroblast growth factor binding GO:0017134 9.13 FGFR1 FGFR2 FGFR3
7 fibroblast growth factor-activated receptor activity GO:0005007 8.8 FGFR1 FGFR2 FGFR3
8 protein binding GO:0005515 10.11 BHLHA9 EFNB1 FGFR1 FGFR2 FGFR3 FLNB
9 DNA binding GO:0003677 10.09 BHLHA9 GLI3 GSC HOXA11 MECOM MSX2

Sources for Synostosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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