Aliases & Classifications for Synostosis

MalaCards integrated aliases for Synostosis:

Name: Synostosis 12 52 42 14

Classifications:



External Ids:

Disease Ontology 12 DOID:11971
MeSH 42 D013580
UMLS 69 C0039093

Summaries for Synostosis

Disease Ontology : 12 A dysostosis that results_in abnormal fusing of adjacent bones.

MalaCards based summary : Synostosis is related to apert syndrome and antley-bixler syndrome without genital anomalies or disordered steroidogenesis. An important gene associated with Synostosis is HOXA11 (Homeobox A11), and among its related pathways/superpathways are PAK Pathway and MAPK signaling pathway. The drugs Tranexamic Acid and Antifibrinolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and brain, and related phenotypes are growth/size/body region and craniofacial

Wikipedia : 72 Synostosis (plural: synostoses) is fusion of two bones. It can be normal in puberty, fusion of the... more...

Related Diseases for Synostosis

Diseases related to Synostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
id Related Disease Score Top Affiliating Genes
1 apert syndrome 32.4 FGFR2 FGFR3 RAB23
2 antley-bixler syndrome without genital anomalies or disordered steroidogenesis 31.4 FGFR1 FGFR2 FGFR3 GLI3 RAB23 TWIST1
3 spondylocarpotarsal synostosis syndrome 12.2
4 radioulnar synostosis 12.1
5 congenital radio-ulnar synostosis 12.1
6 radioulnar synostosis with amegakaryocytic thrombocytopenia 2 12.0
7 radioulnar synostosis with microcephaly, short stature, scoliosis, and mental retardation 12.0
8 radioulnar synostosis with amegakaryocytic thrombocytopenia 1 12.0
9 radioulnar synostosis with amegakaryocytic thrombocytopenia 11.9
10 humeroradial synostosis 11.8
11 humeroradioulnar synostosis 11.8
12 lambdoid synostosis 11.8
13 humero-ulnar synostosis 11.7
14 tibio-fibular synostosis 11.7
15 craniosynostosis-hydrocephalus-arnold-chiari malformation type i-radioulnar synostosis syndrome 11.7
16 radioulnar synostosis, unilateral, with developmental retardation and hypotonia 11.7
17 coronal synostosis, syndactyly and jejunal atresia 11.7
18 muenke syndrome 11.6
19 fgfr2-related isolated coronal synostosis 11.6
20 humero-ulnar synostosis, bilateral 11.6
21 cleft palate colobomata radial synostosis deafness 11.6
22 congenital heart disease radio ulnar synostosis mental retardation 11.6
23 deafness-genital anomalies-metacarpal and metatarsal synostosis syndrome 11.6
24 radio-ulnar synostosis type 1 11.6
25 radio-ulnar synostosis type 2 11.6
26 humero-radial synostosis, unilateral 11.6
27 humero-radial synostosis, bilateral 11.6
28 synostosis of talus and calcaneus short stature 11.6
29 humero-radio-ulnar synostosis, unilateral 11.6
30 humero-radio-ulnar synostosis, bilateral 11.6
31 radio-ulnar synostosis, unilateral 11.6
32 fgfr3-related isolated coronal synostosis 11.6
33 radio-ulnar synostosis, bilateral 11.6
34 humero-ulnar synostosis, unilateral 11.6
35 antley-bixler syndrome 11.6
36 mesomelic dysplasia, kantaputra type 11.3
37 calcaneonavicular coalition 11.2
38 3mc syndrome 11.1
39 cardiospondylocarpofacial syndrome 11.1
40 craniosynostosis 11.1
41 saethre-chotzen syndrome 11.0
42 craniofrontonasal dysplasia 11.0
43 klippel-feil syndrome 10.9
44 jorgenson lenz syndrome 10.9
45 anophthalmos with limb anomalies 10.9
46 cenani-lenz syndactyly syndrome 10.9
47 ischiocoxopodopatellar syndrome 10.8
48 banki syndrome 10.8
49 syndactyly, mesoaxial synostotic, with phalangeal reduction 10.8
50 osebold-remondini syndrome 10.8

Graphical network of the top 20 diseases related to Synostosis:



Diseases related to Synostosis

Symptoms & Phenotypes for Synostosis

MGI Mouse Phenotypes related to Synostosis:

44 (show all 18)
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.41 EFNB1 FGFR1 FGFR2 FGFR3 FLNB GDF5
2 craniofacial MP:0005382 10.4 FGFR2 FGFR3 FLNB GLI3 GSC LRP4
3 limbs/digits/tail MP:0005371 10.39 BHLHA9 EFNB1 FGFR1 FGFR2 FGFR3 FLNB
4 mortality/aging MP:0010768 10.39 MECOM MSX2 NELL1 NOG RAB23 RIPK4
5 cellular MP:0005384 10.38 BHLHA9 EFNB1 FGFR1 FGFR2 FGFR3 FLNB
6 behavior/neurological MP:0005386 10.32 FGFR1 FGFR2 FGFR3 FLNB GSC LRP4
7 embryo MP:0005380 10.28 LRP4 MECOM MSX2 NOG RAB23 TWIST1
8 integument MP:0010771 10.26 EFNB1 FGFR1 FGFR2 FGFR3 GLI3 GSC
9 digestive/alimentary MP:0005381 10.25 EFNB1 FGFR1 FGFR2 FGFR3 GLI3 GSC
10 endocrine/exocrine gland MP:0005379 10.22 HOXA11 LRP4 MSX2 NOG TCF12 EFNB1
11 nervous system MP:0003631 10.21 EFNB1 FGFR1 FGFR2 FGFR3 FLNB GLI3
12 hearing/vestibular/ear MP:0005377 10.15 NOG EFNB1 FGFR1 FGFR2 FGFR3 GLI3
13 reproductive system MP:0005389 9.96 EFNB1 FGFR1 FGFR2 FGFR3 GDF5 GLI3
14 muscle MP:0005369 9.95 NOG TWIST1 FGFR1 FGFR2 GSC MECOM
15 respiratory system MP:0005388 9.9 GLI3 GSC LRP4 MECOM NELL1 NOG
16 renal/urinary system MP:0005367 9.87 FGFR1 FGFR2 FGFR3 GLI3 HOXA11 LRP4
17 skeleton MP:0005390 9.86 EFNB1 FGFR1 FGFR2 FGFR3 FLNB GDF5
18 vision/eye MP:0005391 9.28 EFNB1 FGFR1 FGFR2 FGFR3 GLI3 GSC

Drugs & Therapeutics for Synostosis

Drugs for Synostosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 4,Phase 3 1197-18-8 5526
2 Antifibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1
3 Coagulants Phase 4,Phase 3,Phase 2,Phase 1
4 Hemostatics Phase 4,Phase 3,Phase 2,Phase 1
5 Skullcap Nutraceutical Phase 4,Phase 1
6
Aminocaproic Acid Approved, Investigational Phase 2,Phase 1 60-32-2 564
7
Menthol Approved 2216-51-5 16666
8
Iron Approved 7439-89-6 23925
9 Analgesics
10 Peripheral Nervous System Agents
11
Bilirubin 635-65-4 5280352
12 Calcium, Dietary
13 Epoetin alfa 113427-24-0
14 Ferrous fumarate
15 Hematinics
16 Micronutrients
17 Trace Elements
18 Calamus Nutraceutical

Interventional clinical trials:

(show all 34)

id Name Status NCT ID Phase Drugs
1 The Efficacy and Population Pharmacokinetics of Tranexamic Acid for Craniosynostosis Surgery Recruiting NCT02188576 Phase 4 high dose TXA;Low dose TXA
2 Tranexamic Acid for Craniofacial Surgery Terminated NCT00722436 Phase 4 Tranexamic acid;saline
3 Comparison of a Bone Product to Bone Dust in Ossification of Small Calvarial Defects. Withdrawn NCT01006148 Phase 4
4 Blood Loss and Transfusion Requirement in Infants Treated With Tranexamic Acid Unknown status NCT01094977 Phase 3 Tranexamic Acid;Tranexamic Acid;Saline Placebo
5 Efficacy of Amicar for Children Having Craniofacial Surgery Recruiting NCT02229968 Phase 2 Amicar (ε-aminocaproic acid);normal saline
6 Stem Cells and Tibial Fractures Completed NCT00632034 Phase 1
7 Amicar Pharmacokinetics of Children Having Craniofacial Surgery Completed NCT00912119 Phase 1 Epsilon-Aminocaproic Acid;Epsilon-Aminocaproic Acid;Epsilon-Aminocaproic Acid;Epsilon-Aminocaproic Acid
8 Mononucleotide Autologous Stem Cells and Demineralized Bone Matrix in the Treatment of Non Union/Delayed Fractures Unknown status NCT01435434
9 The Effect of Gender on the Consumption of Pain Medication in Infants Undergoing Craniosynostosis Repair or Untethering of Cord in ITU Unknown status NCT01996163
10 Treatment of Displaced Lateral Clavicle Fractures Using a Locking Compression Plate With Lateral Extension Completed NCT02256059
11 Evaluation of Effects of Clavicular Hook Plate on Subacromial Space Completed NCT01205763
12 Qualitative and Quantitative Study Which Aims to Determine the Specifics of the Announcement for the Diagnosis of Patients With Craniosynostosis and Their Parents to Better Support Them in Their Care Completed NCT02287805
13 Effect of Tranexamic Acid Based on Pharmacokinetics in Pediatric Patients Undergoing Craniosynostosis Surgery: Randomized Controlled Trial Completed NCT02180321 Tranexamic Acid;normal saline
14 Nautilus: Dynamic Craniotomy; New Surgical Technique and Preliminary Results Completed NCT01672619
15 Genetic Analysis of Craniosynostosis, Philadelphia Type Completed NCT00367796
16 Child and Infant Learning Project Completed NCT00077831
17 Treatment of Cranial Molding Deformities in Preterm Infants Completed NCT02366936
18 National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions Completed NCT01322165
19 Transtibial Amputation Outcomes Study Recruiting NCT01821976
20 Network Of Clinical Research Studies On Craniosynostosis, Skull Malformations With Premature Fusion Of Skull Bones Recruiting NCT03025763
21 Cancer in Inherited Bone Marrow Failure Syndromes Recruiting NCT00027274
22 MRI for Non-invasive Evaluation of Brain Stress Recruiting NCT01898650
23 Optic Nerve Sheath Diameter in Craniosynostosis Recruiting NCT03131245
24 Comparison of Scar Formation in Syndactyly Release Surgery With Full Thickness Skin Graft Versus Skin Graft Substitute Recruiting NCT03107546
25 Osteogenic Profiling of Tissue From Children With Craniosynostosis Recruiting NCT00773643
26 Treatment of Proximal Interphalangeal Joint Injuries. Clinical Efficiency of Syndactyly Treatment and Digital Compression Recruiting NCT02548260
27 Clinical Study of Muenke Syndrome (FGFR3-Related Craniosynostosis) Recruiting NCT00106977
28 Irradiated Blood Versus Non Irradiated Blood Transfusions in Craniosynostosis Repair Recruiting NCT02483702
29 Bohring-Opitz Syndrome and ASXL Registry Recruiting NCT03303716
30 Syndactyly Repair: Comparison of Skin Graft and No Skin Graft Techniques Active, not recruiting NCT01416090
31 Comparison of the Rate of Preoperative Haemoglobin After Administration of Epoetin Alpha Associated With an Oral Medical Supplementation Versus Intravenous Before Surgery of Craniosynostosis at the Child Not yet recruiting NCT03231085 Ferrous fumarate
32 Cranial Cup Use for the Prevention of Positional Head Shape Deformity in the NICU Terminated NCT01218087
33 Endoscopic Treatment for Isolated, Single Suture Craniosynostosis Withdrawn NCT00769847
34 Hanger Helmet Study Withdrawn NCT02561728

Search NIH Clinical Center for Synostosis

Cochrane evidence based reviews: synostosis

Genetic Tests for Synostosis

Anatomical Context for Synostosis

MalaCards organs/tissues related to Synostosis:

39
Bone, Skin, Brain, Bone Marrow, Thyroid, Eye, Testes

Publications for Synostosis

Articles related to Synostosis:

(show top 50) (show all 679)
id Title Authors Year
1
Delayed Presentation of Isolated Sagittal Synostosis With Raised Intracranial Pressure and Secondary Chiari Malformation With Cervical Syringomyelia. ( 28582306 )
2017
2
Temporal Deformity Objectively Measured Before and After Surgery for Metopic Synostosis: Retrusion Rather than Hollowing. ( 28885443 )
2017
3
Treated Unilateral Lambdoid Synostosis Using Cranium Distraction Osteogenesis With Z-shaped Osteotomy. ( 28059851 )
2017
4
Squamous Suture Synostosis: A Review With Emphasis on Cranial Morphology and Involvement of Other Cranial Sutures. ( 27831981 )
2017
5
Effect of Preoperative Molding Helmet in Patients With Sagittal Synostosis. ( 28549045 )
2017
6
Cranioplasty without Periosteal Dissection Reduces Blood Loss in Pi-Plasty Surgery for Sagittal Synostosis. ( 28693016 )
2017
7
The Degree of Surgical Frontal Volume Correction in Metopic Synostosis Determines Long-Term Outcomes. ( 28358760 )
2017
8
The Management of Trigonoscaphocephaly as a Result of Combined Metopic and Sagittal Synostosis. ( 28538575 )
2017
9
Comparing Outcomes and Cost of 3 Surgical Treatments for Sagittal Synostosis: A Retrospective Study Including Procedure-Related Cost Analysis. ( 28449032 )
2017
10
Filamin B Loss-of-Function Mutation in Dimerization Domain Causes Autosomal-Recessive Spondylocarpotarsal Synostosis Syndrome with Rib Anomalies. ( 28145000 )
2017
11
The use of indomethacin in the prevention of postoperative radioulnar synostosis after distal biceps repair. ( 28104092 )
2017
12
Transtibial Amputation Outcomes Study (TAOS): Comparing Transtibial Amputation With and Without a Tibiofibular Synostosis (Ertl) Procedure. ( 28323804 )
2017
13
Scaphoid Fracture in a Patient with a Scaphotrapezial Synostosis: A Case Report and Literature Review. ( 28197353 )
2017
14
Update on Treatment of Sagittal Synostosis: What Can We Learn From the 16th Congress of the International Society of Craniofacial Surgery? ( 28468130 )
2017
15
Pathological fracture in a patient with an untreated congenital metacarpal synostosis. ( 28193122 )
2017
16
A case of failure to correct humerus-radius synostosis and thumb hypoplasia. ( 28823203 )
2017
17
Bilateral capitato-hamato-trapezoidal synostosis. ( 28713069 )
2017
18
Squamosal Suture Synostosis: Incidence, Associations, and Implications for Treatment. ( 28538065 )
2017
19
A 590 kb deletion caused by non-allelic homologous recombination between two LINE-1 elements in a patient with mesomelia-synostosis syndrome. ( 28328141 )
2017
20
Post-Surgical Relapse in Metopic Synostosis and Limitations of the Interfrontal Angle as an Outcome Measure. ( 28665858 )
2017
21
The Dorsoulnar Artery Perforator Adipofascial Flap in the Treatment of Distal Radioulnar Synostosis. ( 28811948 )
2017
22
Congenital radioulnar synostosis. ( 28828125 )
2017
23
A postnatal role for embryonic myosin revealed by MYH3 mutations that alter TGFI^ signaling and cause autosomal dominant spondylocarpotarsal synostosis. ( 28205584 )
2017
24
Internal Distraction Osteogenesis With Piezosurgery Oblique Osteotomy of Supraorbital Margin of Frontal Bone for the Treatment of Unilateral Coronal Synostosis. ( 27845963 )
2016
25
Cerebrospinal fluid collections in sagittal suture synostosis. ( 26767840 )
2016
26
Plagiocephaly due to Frontosphenoidal Suture Synostosis: Report of 2 Cases and Literature Review. ( 26960206 )
2016
27
Minimally Invasive Strip Craniectomy Simplifies Anesthesia Practice in Patients With Isolated Sagittal Synostosis. ( 28005739 )
2016
28
Minimally Invasive Strip Craniectomy Simplifies Anesthesia Practice in Patients With Isolated Sagittal Synostosis. ( 27579560 )
2016
29
Long-term results after a free vascularized adipofascial graft for congenital proximal radioulnar synostosis with an average follow-up of 10 years: a series of four cases. ( 27422459 )
2016
30
Photometric evaluation of cranial and facial symmetry in hemicoronal single suture synostosis treated with surgical fronto-orbital remodeling. ( 27288326 )
2016
31
Thoracoscopic Resection of a Symptomatic, Congenital Rib Synostosis. ( 27000588 )
2016
32
Isolated Unilateral Frontosphenoidal Suture Synostosis in Six Patients: Lessons Learned in Diagnosis and Treatment. ( 27152571 )
2016
33
Monozygotic twins presenting with isolated sagittal and bicoronal synostosis, respectively. ( 26925815 )
2016
34
Stepwise Removal of The Fused Midline Parietal Bone to Avoid Superior Sagittal Sinus Injury in Infants with Sagital Synostosis. ( 27593802 )
2016
35
Quantifying Craniometric Change Early After Fronto-Orbital Advancement in Metopic Synostosis. ( 27513770 )
2016
36
Objective Assessment of the Interfrontal Angle for Severity Grading and Operative Decision-Making in Metopic Synostosis. ( 27119927 )
2016
37
Concurrent occurrence of an inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving MAP2K2 in a patient with developmental delay, distinctive facial features, and lambdoid synostosis. ( 27751966 )
2016
38
Synostosis of proximal phalangeal bases for loss of distal metacarpal. ( 27904227 )
2016
39
Anthropometric Outcomes following Fronto-Orbital Advancement for Metopic Synostosis. ( 27119926 )
2016
40
Unilateral coronal synostosis: can we trust the sagittal suture as a landmark for the underlying superior sagittal sinus? ( 26745648 )
2016
41
Distal tibiofibular synostosis after surgically resolved ankle fractures: An epidemiological, clinical and morphological evaluation of a patient sample. ( 27645618 )
2016
42
The metopic index: an anthropometric index for the quantitative assessment of trigonocephaly from metopic synostosis. ( 27153376 )
2016
43
Surgical Treatment of Posttraumatic Radioulnar Synostosis. ( 26977328 )
2016
44
Volume measurements on three-dimensional photogrammetry after extended strip versus total cranial remodeling for sagittal synostosis: A comparative cohort study. ( 27591089 )
2016
45
Diaphyseal tibiofibular synostosis in professional athletes: Report of 2 cases. ( 26615768 )
2016
46
Capitate-trapezoid synostosis: Analysis of an early bronze age case and review of the literature. ( 27813627 )
2016
47
Endoscope-assisted management of sagittal synostosis: wide vertex suturectomy and barrel stave osteotomies versus narrow vertex suturectomy. ( 27611899 )
2016
48
The Management of Nonsyndromic, Isolated Sagittal Synostosis. ( 26825739 )
2016
49
Comparison of Intracranial Volume and Cephalic Index After Correction of Sagittal Synostosis With Spring-assisted Surgery or Pi-plasty. ( 26963298 )
2016
50
A new quantitative image-based method for evaluation of bony temporal hollowing in metopic synostosis. ( 27125314 )
2016

Variations for Synostosis

Expression for Synostosis

Search GEO for disease gene expression data for Synostosis.

Pathways for Synostosis

GO Terms for Synostosis

Cellular components related to Synostosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.47 BHLHA9 EFNB1 FGFR1 FGFR2 FGFR3 FLNB

Biological processes related to Synostosis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
id Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.97 FGFR1 GLI3 HOXA11 NELL1
2 skeletal system development GO:0001501 9.93 FGFR1 FGFR3 HOXA11 NOG
3 multicellular organism development GO:0007275 9.93 BHLHA9 EFNB1 FLNB GSC HOXA11 LRP4
4 phosphatidylinositol-mediated signaling GO:0048015 9.9 FGFR1 FGFR2 FGFR3
5 osteoblast differentiation GO:0001649 9.89 MSX2 NOG TWIST1
6 phosphatidylinositol phosphorylation GO:0046854 9.89 FGFR1 FGFR2 FGFR3
7 in utero embryonic development GO:0001701 9.89 FGFR1 FGFR2 GLI3 NOG TWIST1
8 anterior/posterior pattern specification GO:0009952 9.88 GLI3 HOXA11 MSX2
9 lung development GO:0030324 9.88 FGFR1 FGFR2 GLI3
10 BMP signaling pathway GO:0030509 9.88 LRP4 MSX2 NOG
11 positive regulation of MAPK cascade GO:0043410 9.88 FGFR1 FGFR2 FGFR3
12 positive regulation of neuron differentiation GO:0045666 9.87 FGFR1 GDF5 TCF12
13 fibroblast growth factor receptor signaling pathway GO:0008543 9.87 FGFR1 FGFR2 FGFR3
14 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.87 FGFR1 FGFR2 FGFR3
15 cartilage development GO:0051216 9.85 GDF5 MSX2 NOG
16 muscle organ development GO:0007517 9.85 FLNB MYH3 TCF12 TWIST1
17 positive regulation of epithelial cell proliferation GO:0050679 9.84 FGFR2 NOG TWIST1
18 negative regulation of cell differentiation GO:0045596 9.83 GLI3 NOG TWIST1
19 positive regulation of osteoblast differentiation GO:0045669 9.83 GLI3 MSX2 NELL1
20 wound healing GO:0042060 9.83 FGFR2 GLI3 MSX2 NOG
21 embryonic skeletal system morphogenesis GO:0048704 9.81 GLI3 GSC TWIST1
22 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.81 FGFR1 FGFR2 FGFR3
23 ureteric bud development GO:0001657 9.8 FGFR1 FGFR2 NOG
24 chondrocyte differentiation GO:0002062 9.79 FGFR1 FGFR3 GDF5
25 limb development GO:0060173 9.77 GLI3 LRP4 NOG
26 odontogenesis GO:0042476 9.77 FGFR2 MSX2 TWIST1
27 embryonic forelimb morphogenesis GO:0035115 9.75 HOXA11 MSX2 TWIST1
28 bone morphogenesis GO:0060349 9.74 FGFR2 FGFR3 MSX2
29 embryonic digestive tract morphogenesis GO:0048557 9.72 FGFR2 GLI3
30 anatomical structure formation involved in morphogenesis GO:0048646 9.72 GLI3 NOG
31 endocardial cushion morphogenesis GO:0003203 9.71 NOG TWIST1
32 anatomical structure development GO:0048856 9.71 GLI3 LRP4
33 branching involved in salivary gland morphogenesis GO:0060445 9.7 FGFR1 FGFR2
34 hindlimb morphogenesis GO:0035137 9.69 GDF5 TWIST1
35 proximal/distal pattern formation GO:0009954 9.69 GLI3 HOXA11 LRP4
36 organ induction GO:0001759 9.68 FGFR1 HOXA11
37 embryonic skeletal joint morphogenesis GO:0060272 9.68 HOXA11 NOG
38 lung-associated mesenchyme development GO:0060484 9.68 FGFR1 FGFR2
39 outer ear morphogenesis GO:0042473 9.67 FGFR1 TWIST1
40 membranous septum morphogenesis GO:0003149 9.67 FGFR2 NOG
41 dorsal/ventral pattern formation GO:0009953 9.67 GLI3 HOXA11 LRP4 NOG
42 bone development GO:0060348 9.65 FGFR2 TWIST1
43 BMP signaling pathway involved in heart development GO:0061312 9.65 MSX2 NOG
44 middle ear morphogenesis GO:0042474 9.65 FGFR1 GSC NOG
45 cranial suture morphogenesis GO:0060363 9.64 MSX2 TWIST1
46 positive regulation of chondrocyte differentiation GO:0032332 9.63 GDF5 GLI3 HOXA11
47 frontal suture morphogenesis GO:0060364 9.61 GLI3 MSX2
48 orbitofrontal cortex development GO:0021769 9.61 FGFR1 FGFR2
49 ventricular zone neuroblast division GO:0021847 9.58 FGFR1 FGFR2
50 mesenchymal cell differentiation GO:0048762 9.58 FGFR1 FGFR2 NOG

Molecular functions related to Synostosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.88 FGFR1 FGFR2 LRP4 NOG TCF12 TWIST1
2 nucleotide binding GO:0000166 9.72 FGFR1 FGFR2 FGFR3 MYH3 RAB23
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.63 FGFR1 FGFR2 FGFR3
4 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.54 FGFR1 FGFR2 FGFR3
5 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.43 FGFR1 FGFR2 FGFR3
6 1-phosphatidylinositol-3-kinase activity GO:0016303 9.33 FGFR1 FGFR2 FGFR3
7 fibroblast growth factor binding GO:0017134 9.13 FGFR1 FGFR2 FGFR3
8 fibroblast growth factor-activated receptor activity GO:0005007 8.8 FGFR1 FGFR2 FGFR3
9 protein binding GO:0005515 10.36 BHLHA9 EFNB1 FGFR1 FGFR2 FGFR3 FLNB

Sources for Synostosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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