MCID: SYN006
MIFTS: 51

Synovial Sarcoma malady

Cancer diseases category

Summaries for Synovial Sarcoma

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42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Synovial sarcoma is rare and aggressive soft tissue sarcoma that appears as deep, painless, slowly growing masses. most frequently the tumor affects the legs, especially the knees, and the arms. less frequently, this disease develops in the trunk, head and neck region, or the abdomen. although synovial sarcoma does not have a clearly defined cause, genetic factors are believed to influence the development of this disease. cells in these tumors are usually characterized by the presence of a translocation involving chromosomes x and 18. this translocation is specific to synovial sarcoma and is often used to diagnose this cancer. although this condition generally affects adults, about 30% of reported cases occur in children and adolescents. last updated: 7/11/2011

MalaCards: Synovial Sarcoma, also known as sarcoma, synovial, is related to sarcoma and hemangiopericytoma. An important gene associated with Synovial Sarcoma is SSX2 (synovial sarcoma, X breakpoint 2), and among its related pathways is Transcriptional misregulation in cancer. Affiliated tissues include lung, kidney and breast.

Wikipedia:63 A synovial sarcoma (also known as: malignant synovioma) is a rare form of cancer which usually occurs... more...

Description from OMIM:46 312820,300813

Aliases & Classifications for Synovial Sarcoma

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
synovial sarcoma:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

synovial sarcoma 8 42 10 48 60
sarcoma, synovial 9 46
sarcoma synovial 44
synovialosarcoma 48


External Ids:

Disease Ontology8 DOID:5485
NCIt39 C3400
MeSH34 D013584
SNOMED-CT56 63211008, 302851001
SNOMED-CT via Orphanet57 63211008, 302851001
ICD10 via Orphanet26 C49.9

Related Diseases for Synovial Sarcoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Synovial Sarcoma:



Diseases related to synovial sarcoma

Clinical Features for Synovial Sarcoma

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46OMIM
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Clinical features from OMIM:

312820,300813

Drugs & Therapeutics for Synovial Sarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Synovial Sarcoma

Drug clinical trials:

Search ClinicalTrials for Synovial Sarcoma

Search NIH Clinical Center for Synovial Sarcoma

Search CenterWatch for Synovial Sarcoma

Genetic Tests for Synovial Sarcoma

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Anatomical Context for Synovial Sarcoma

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32MalaCards
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MalaCards organs/tissues related to Synovial Sarcoma:

32
Lung, Kidney, Breast, Bone, Heart, Thyroid, Tongue, Prostate, Spinal cord, Small intestine, Liver, Smooth muscle, Endothelial, Tonsil, Testes, Testis, Cerebellum, Uterus, Lymph node, Colon, Pancreas, Brain, Trachea

Animal Models for Synovial Sarcoma or affiliated genes

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Publications for Synovial Sarcoma

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50PubMed
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Articles related to Synovial Sarcoma:

(show top 50)    (show all 725)
idTitleAuthorsYear
1
Twist1 is essential in maintaining mesenchymal state and tumor-initiating properties in synovial sarcoma. (24051309)
2014
2
Synovial sarcoma in cerebellum: a case report and literature review. (23223956)
2014
3
Identification of target genes of synovial sarcoma-associated fusion oncoprotein using human pluripotent stem cells. (23313505)
2013
4
50 years ago in CORR: Synovial sarcoma. Kirk J. Anderson, MD and Orliss Wildermuth, MD CORR 1961;29:55-70. (23344847)
2013
5
Primary synovial sarcoma of the parietal pleura: a case report. (23614107)
2013
6
Pulmonary metastasectomy in pediatric/adolescent patients with synovial sarcoma: an institutional review. (23583130)
2013
7
Monophasic Synovial Sarcoma of the Lung. (24139331)
2013
8
Poorly differentiated synovial sarcoma showing Homer-Wright rosette structures: a potential diagnostic pitfall. (23030377)
2013
9
Monophasic epithelial synovial sarcoma accompanied by an inverted papilloma in the sphenoid sinus. (23251173)
2012
10
Synovial sarcoma of the lateral pharyngeal wall. (22819223)
2012
11
Clinical and pathological features of primary renal synovial sarcoma: analysis of 64 cases from 11 years of medical literature. (22452647)
2012
12
Resection of a giant primary synovial sarcoma of the inferior vena cava extending into the right atrium with caval reconstruction under cardiopulmonary bypass and circulatory arrest. (23282650)
2012
13
Prevalence and prognostic influence of genomic changes of EGFR pathway markers in synovial sarcoma. (21240992)
2011
14
Cyclooxygenase-2 expression is not associated with clinical outcome in synovial sarcoma. (21874258)
2011
15
Analysis of SYT/SSX1 and SYT/SSX2 fusion genes from synovial sarcoma]. (22393780)
2011
16
Synovial sarcoma arising in the foot: case report. (21172645)
2011
17
Laryngeal synovial sarcoma: case report and literature review. (21177209)
2011
18
Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors, and malignant peripheral nerve sheath tumors. (21531005)
2011
19
SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 protein. (21454665)
2011
20
Myricetin inhibits IL-1beta-induced inflammatory mediators in SW982 human synovial sarcoma cells. (20403460)
2010
21
Unexpected diagnosis for an adrenal tumor: synovial sarcoma. (20123459)
2010
22
Cryptic SYT/SXX1 fusion gene in high-grade biphasic synovial sarcoma with unique complex rearrangement and extensive BCL2 overexpression. (20082858)
2010
23
Radiologic case study: your diagnosis? Synovial sarcoma. (21117558)
2010
24
Primary retroperitoneal synovial sarcoma in CT and MRI. (20842258)
2010
25
Cytogenetic heterogeneity in biphasic synovial sarcoma associated with telomere instability. (20113844)
2010
26
Aggressive repeat surgery for a recurrent synovial sarcoma in the pleura. (19262450)
2009
27
Synovial sarcoma involving the head: analysis of 36 cases with predilection to the parotid and temporal regions. (19623036)
2009
28
Synovial sarcoma of the tongue: case report and review of the literature. (19304058)
2009
29
The classic prognostic factors tumor stage, tumor size, and tumor grade are the strongest predictors of outcome in synovial sarcoma: no role for SSX fusion type or ezrin expression. (18997619)
2009
30
Prospective evaluation of TLE1 as a diagnostic immunohistochemical marker in synovial sarcoma. (19809272)
2009
31
Rebound thymic hyperplasia after pneumonectomy and chemotherapy for primary synovial sarcoma. (18728544)
2008
32
Molecular characterization of synovial sarcoma in children and adolescents: evidence of akt activation. (18633459)
2008
33
Primary synovial sarcoma of the kidney. (18445550)
2008
34
Synovial sarcoma of the parapharyngeal space. (17056221)
2007
35
Survival in patients with synovial sarcoma of the head and neck: association with tumor location, size, and extension. (17274049)
2007
36
Long-term outcomes for synovial sarcoma treated with conservation surgery and radiotherapy. (17689031)
2007
37
The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway. (17686994)
2007
38
Immunostaining for SYT protein discriminates synovial sarcoma from other soft tissue tumors: analysis of 146 cases. (17334346)
2007
39
A case of monophasic synovial sarcoma presenting as a vulvar mass. (16226798)
2006
40
Gene expression profiling of human synovial sarcoma cell line (Hs701.T) in response to IL-1beta stimulation. (16955392)
2006
41
Expressions and significance of E-cadherin and beta-catenin in synovial sarcoma]. (16483482)
2005
42
Aberrant expression of tight junction-related proteins ZO-1, claudin-1 and occludin in synovial sarcoma: an immunohistochemical study with ultrastructural correlation. (14704716)
2004
43
Targeting other abnormal signaling pathways in sarcoma: EGFR in synovial sarcomas, PPAR-gamma in liposarcomas. (15217223)
2004
44
Identification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma. (11308259)
2001
45
Cystic synovial sarcoma. (11172207)
2001
46
Persistent interstitial pulmonary emphysema-like cyst associated with metastatic synovial sarcoma. (10890254)
2000
47
Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus. (10072425)
1999
48
Dual colour fluorescence in situ hybridization to paraffin-embedded samples to deduce the presence of the der(X)t(X;18)(p11.2;q11.2) and involvement of either the SSX1 or SSX2 gene: a diagnostic and prognostic aid for synovial sarcoma. (10398111)
1999
49
Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript. (7495284)
1995
50
Keratin in the epithelial-like cells of classical biphasic synovial sarcoma. (6182681)
1982

Genetic Variations for Synovial Sarcoma

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Expression for genes affiliated with Synovial Sarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Synovial Sarcoma

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Pathways for genes affiliated with Synovial Sarcoma

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29KEGG
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Pathways related to Synovial Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7SSX1, SS18, SSX2B, SSX2

Compounds for genes affiliated with Synovial Sarcoma

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GO Terms for genes affiliated with Synovial Sarcoma

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16Gene Ontology
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Cellular components related to Synovial Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.0SSX2IP, SSX7, SS18L1, SSX2B, SSX4B, SSX5

Biological processes related to Synovial Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of transcription, DNA-dependentGO:00635510.9SSX7, SSX2B, SSX4B, SSX5, SSX1, SSX3
2transcription, DNA-dependentGO:00635110.6SSX8, SSX6, SSX7, SS18L1, SSX2B, SSX4B

Molecular functions related to Synovial Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleic acid bindingGO:00367610.9SSX8, SSX9, SSX3, SSX1, SSX5, SSX4B

Products for genes affiliated with Synovial Sarcoma

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Sources for Synovial Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet