MCID: SYN006
MIFTS: 49

Synovial Sarcoma malady

Rare diseases, Cancer diseases categories
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Summaries for Synovial Sarcoma

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Sources:
43NIH Rare Diseases, 65Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Synovial sarcoma is rare and aggressive soft tissue sarcoma that appears as deep, painless, slowly growing masses. most frequently the tumor affects the legs, especially the knees, and the arms. less frequently, this disease develops in the trunk, head and neck region, or the abdomen. although synovial sarcoma does not have a clearly defined cause, genetic factors are believed to influence the development of this disease. cells in these tumors are usually characterized by the presence of a translocation involving chromosomes x and 18. this translocation is specific to synovial sarcoma and is often used to diagnose this cancer. although this condition generally affects adults, about 30% of reported cases occur in children and adolescents. last updated: 7/11/2011

MalaCards: Synovial Sarcoma, also known as sarcoma, synovial, is related to sarcoma and monophasic synovial sarcoma. An important gene associated with Synovial Sarcoma is SSX2 (synovial sarcoma, X breakpoint 2), and among its related pathways is Transcriptional misregulation in cancer. Affiliated tissues include kidney, lung and breast.

Wikipedia:65 A synovial sarcoma (also known as: malignant synovioma) is a rare form of cancer which usually occurs... more...

Description from OMIM:47 312820,300813

Aliases & Classifications for Synovial Sarcoma

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8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 59SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Orphanet: 49 
Rare tumors


Characteristics (Orphanet epidemiological data):

49
synovial sarcoma:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

synovial sarcoma 8 43 10 49 62
sarcoma, synovial 9 47
sarcoma synovial 45
synovialosarcoma 49


External Ids:

Disease Ontology8 DOID:5485
NCIt40 C3400
MeSH35 D013584
SNOMED-CT58 302851001, 63211008
SNOMED-CT via Orphanet59 63211008, 302851001
ICD10 via Orphanet26 C49.9
UMLS via Orphanet63 C0039101

Related Diseases for Synovial Sarcoma

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Synovial Sarcoma:



Diseases related to synovial sarcoma

Symptoms for Synovial Sarcoma

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47OMIM
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Clinical features from OMIM:

312820,300813

Drugs & Therapeutics for Synovial Sarcoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Synovial Sarcoma

Search NIH Clinical Center for Synovial Sarcoma

Genetic Tests for Synovial Sarcoma

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Anatomical Context for Synovial Sarcoma

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33MalaCards
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MalaCards organs/tissues related to Synovial Sarcoma:

33
Kidney, Lung, Breast, Bone, Heart, Thyroid, Tongue, Prostate, Spinal cord, Small intestine, Liver, Smooth muscle, Endothelial, Tonsil, Testes, Testis, Cerebellum, Uterus, Lymph node, Colon, Pancreas, Brain, Trachea

Animal Models for Synovial Sarcoma or affiliated genes

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Publications for Synovial Sarcoma

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52PubMed
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Articles related to Synovial Sarcoma:

(show top 50)    (show all 717)
idTitleAuthorsYear
1
Truncated SSX protein suppresses synovial sarcoma cell proliferation by inhibiting the localization of SS18-SSX fusion protein. (24130893)
2013
2
SS18-SSX fusion protein-induced Wnt/I^-catenin signaling is a therapeutic target in synovial sarcoma. (24166495)
2013
3
Primary pulmonary poorly differentiated synovial sarcoma: transducer-like enhancer of split 1 immunohistochemistry as a valuable diagnostic aid. (24014971)
2013
4
Pelvic synovial sarcoma of unknown primary origin: case report and literature review. (24400474)
2013
5
Transoral robotic resection of oropharyngeal synovial sarcoma in a pediatric patient. (23639341)
2013
6
A Pilot Study of Anti-CTLA4 Antibody Ipilimumab in Patients with Synovial Sarcoma. (23554566)
2013
7
Pericardial synovial sarcoma in a dyspnoeic female with tuberculous pericarditis: A case report. (23833678)
2013
8
Monophasic epithelial synovial sarcoma accompanied by an inverted papilloma in the sphenoid sinus. (23251173)
2012
9
Primary synovial sarcoma of the uterus. (21491161)
2012
10
Synovial sarcoma of the pharynx causing airway obstruction. (22256940)
2012
11
Synovial sarcoma involving the median nerve: a case report. (23011830)
2012
12
Synovial sarcoma of the infratemporal fossa with extension into the oral cavity--a rare presentation and literature review. (22607831)
2012
13
Primary synovial sarcoma involving the submandibular gland. (22727109)
2012
14
Biphasic synovial sarcoma in the cervical spine: Case report. (21605432)
2011
15
Pulmonary synovial sarcoma and pneumothorax. (21263255)
2011
16
Biphasic synovial sarcoma of the extremity: quadruple approach of isolated limb perfusion, surgical ablation, adipofascial perforator flap and radiation to avoid amputation. (21516237)
2011
17
Correlation between DNA ploidy, metaphase high-resolution comparative genomic hybridization results and clinical outcome of synovial sarcoma. (22053830)
2011
18
Synovial sarcoma individual chemotherapy directed by collagen gel droplet embedded culture drug sensitivity test: A case report. (22966400)
2010
19
Myricetin inhibits IL-1beta-induced inflammatory mediators in SW982 human synovial sarcoma cells. (20403460)
2010
20
Primary pleuropulmonary synovial sarcoma. (21513626)
2010
21
Synovial sarcoma involving the calcaneus and plantar compartment of the foot: a case report. (20537566)
2010
22
Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration. (19333234)
2009
23
Primary breast synovial sarcoma: a rare primary breast neoplasm. (20045794)
2009
24
Growth suppression and apoptosis induction in synovial sarcoma cell lines by a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ). (18760530)
2008
25
The diagnostic value of SYT-SSX detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH) for synovial sarcoma: a review and prospective study of 255 cases. (18460022)
2008
26
Poorly differentiated synovial sarcoma of the vagina: a case report and a clinical literature review. (22275979)
2008
27
A t(X; 18) SYT-SSX2 positive synovial sarcoma in the pelvis of a young adult male: a rare case report with review of literature. (18626152)
2008
28
Rebound thymic hyperplasia after pneumonectomy and chemotherapy for primary synovial sarcoma. (18728544)
2008
29
Molecular characterization of synovial sarcoma in children and adolescents: evidence of akt activation. (18633459)
2008
30
Evaluation of genetic stability of the SYT gene rearrangement by break-apart FISH in primary and xenotransplanted synovial sarcomas. (17175375)
2007
31
Synovial sarcoma of the parapharyngeal space. (17056221)
2007
32
Dysadherin expression as a significant prognostic factor and as a determinant of histologic features in synovial sarcoma: special reference to its inverse relationship with E-cadherin expression. (17197923)
2007
33
Doxorubicin induces cell senescence preferentially over apoptosis in the FU-SY-1 synovial sarcoma cell line. (16705698)
2006
34
Effect of sinomenine on gene expression of the IL-1 beta-activated human synovial sarcoma. (16566946)
2006
35
Loss of p16INK4A expression is associated with allelic imbalance/loss of heterozygosity of chromosome 9p21 in microdissected synovial sarcomas. (16082560)
2005
36
Disruption of fibroblast growth factor signal pathway inhibits the growth of synovial sarcomas: potential application of signal inhibitors to molecular target therapy. (15814652)
2005
37
Identification of PDZK4, a novel human gene with PDZ domains, that is upregulated in synovial sarcomas. (15077175)
2004
38
APC mutations in synovial sarcoma. (11920741)
2002
39
Immunotherapy with autologous dendritic cells and tumor-specific synthetic peptides for synovial sarcoma. (11990310)
2002
40
Identification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma. (11308259)
2001
41
Expression of cadherins and their undercoat proteins (alpha-, beta-, and gamma-catenins and p120) and accumulation of beta-catenin with no gene mutations in synovial sarcoma. (11213832)
2001
42
Primary synovial sarcoma of the kidney: a case report with literature review. (12574853)
2001
43
Poorly differentiated synovial sarcoma: a case report. (11411458)
2001
44
Patterns of keratin polypeptides in 110 biphasic, monophasic, and poorly differentiated synovial sarcomas. (11037348)
2000
45
Usefulness of cytokeratin subsets for distinguishing monophasic synovial sarcoma from malignant peripheral nerve sheath tumor. (10549251)
1999
46
Synovial sarcoma of the pericardium]. (9885009)
1998
47
The SSX-2 gene, which is involved in the t(X;18) translocation of synovial sarcomas, codes for the human tumor antigen HOM-MEL-40. (8840996)
1996
48
Primary pulmonary sarcoma with morphologic features of monophasic synovial sarcoma and chromosome translocation t(X; 18). (8607444)
1996
49
Sublocalization of the synovial sarcoma-associated t(X;18) chromosomal breakpoint in Xp11.2 using cosmid cloning and fluorescence in situ hybridization. (8389029)
1993
50
Monophasic synovial sarcoma of spindle-cell type. Epithelial differentiation as revealed by ultrastructural features, content of prekeratin and binding of peanut agglutinin. (6196906)
1983

Variations for Synovial Sarcoma

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Expression for genes affiliated with Synovial Sarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Synovial Sarcoma

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Pathways for genes affiliated with Synovial Sarcoma

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50PathCards, 30KEGG
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Pathways related to Synovial Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7SSX2, SS18, SSX2B, SSX1

Compounds for genes affiliated with Synovial Sarcoma

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GO Terms for genes affiliated with Synovial Sarcoma

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16Gene Ontology
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Cellular components related to Synovial Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056347.3SSX7, SSX2IP, SSX1, SSX4B, SSX3, SSX6

Biological processes related to Synovial Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of transcription, DNA-templatedGO:0063557.9SSX1, SSX4B, SSX3, SSX6, SSX9, SSX2B
2transcription, DNA-templatedGO:0063517.3SSX7, SSX8, SSX1, SSX4B, SSX3, SSX6

Molecular functions related to Synovial Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleic acid bindingGO:0036767.9SSX7, SSX5, SSX2B, SSX9, SSX6, SSX3

Products for genes affiliated with Synovial Sarcoma

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Sources for Synovial Sarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet