MCID: SYN006
MIFTS: 47

Synovial Sarcoma malady

Cancer category

Summaries for Synovial Sarcoma

Sources:
43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Synovial sarcoma is rare and aggressive soft tissue sarcoma that appears as deep, painless, slowly growing masses. most frequently the tumor affects the legs, especially the knees, and the arms. less frequently, this disease develops in the trunk, head and neck region, or the abdomen. although synovial sarcoma does not have a clearly defined cause, genetic factors are believed to influence the development of this disease. cells in these tumors are usually characterized by the presence of a translocation involving chromosomes x and 18. this translocation is specific to synovial sarcoma and is often used to diagnose this cancer. although this condition generally affects adults, about 30% of reported cases occur in children and adolescents. last updated: 7/11/2011

MalaCards: Synovial Sarcoma, also known as sarcoma, synovial, is related to kidney hemangiopericytoma and monophasic synovial sarcoma. An important gene associated with Synovial Sarcoma is SSX2 (synovial sarcoma, X breakpoint 2), and among its related pathways is Transcriptional misregulation in cancer. Affiliated tissues include lymph node, brain and cerebellum.

Wikipedia:64 A synovial sarcoma (also known as: malignant synovioma) is a rare form of cancer which usually occurs... more...

Description from OMIM:47 312820,300813

Aliases & Classifications for Synovial Sarcoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 61UMLS, 9diseasecard, 47OMIM, 45Novoseek, 57SNOMED-CT, 40NCIt, 35MeSH, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Characteristics (Orphanet epidemiological data):

49
synovial sarcoma:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

synovial sarcoma 8 43 10 49 61
sarcoma, synovial 9 47
sarcoma synovial 45


External Ids:

Disease Ontology8 DOID:5485
NCIt40 C3400
MeSH35 D013584
SNOMED-CT57 63211008, 302851001
ICD10 via Orphanet26 C49.9

Related Diseases for Synovial Sarcoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Synovial Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1kidney hemangiopericytoma30.0SS18, SSX2
2monophasic synovial sarcoma11.0
3biphasic synovial sarcoma10.9
4spindle cell synovial sarcoma10.6
5fibrous synovial sarcoma10.5
6spindle cell sarcoma10.5
7mediastinum synovial sarcoma10.5
8soft tissue sarcoma10.5
9epithelioid cell synovial sarcoma10.4
10small cell sarcoma10.4
11synovial cancer10.4
12thyroid sarcoma10.4
13desmoplastic small round cell tumor10.4
14spinal cord sarcoma10.3
15trachea sarcoma10.3
16vagina sarcoma10.3
17tarsal tunnel syndrome10.2
18sarcomatoid mesothelioma10.2
19solitary fibrous tumor10.2
20neurofibromatosis10.0
21familial mediterranean fever10.0
22pancreas sarcoma10.0
23obstructive jaundice10.0
24interstitial emphysema10.0
25sarcomatoid renal cell carcinoma10.0
26alveolar rhabdomyosarcoma10.0
27brain sarcoma10.0
28gastrointestinal stromal tumor10.0
29sphenoid sinus inverted papilloma10.0
30juvenile rheumatoid arthritis10.0
31extraskeletal myxoid chondrosarcoma10.0
32clear cell sarcoma10.0
33hypercalcemia10.0
34acute leukemia10.0
35adenocarcinoma10.0
36angiomyolipoma10.0
37arthritis10.0
38small intestinal sarcoma10.0
39synovitis10.0
40testis sarcoma10.0
41thyroid cancer10.0
42vulvar sarcoma10.0
43thymic hyperplasia10.0
44osteofibrous dysplasia10.0
45malignant mesenchymal tumor10.0
46mycetoma10.0
47synovial chondromatosis10.0
48synovitis, chronic10.0
49venous thrombosis10.0
50sarcoma10.0MUC1, SSX2, SS18, SSX1

Graphical network of the top 20 diseases related to Synovial Sarcoma:



Diseases related to synovial sarcoma

Clinical Features for Synovial Sarcoma

Sources:
47OMIM
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Clinical features from OMIM:

312820,300813

Drugs & Therapeutics for Synovial Sarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Synovial Sarcoma

Drug clinical trials:

Search ClinicalTrials for Synovial Sarcoma

Search NIH Clinical Center for Synovial Sarcoma

Search CenterWatch for Synovial Sarcoma

Genetic Tests for Synovial Sarcoma

Anatomical Context for Synovial Sarcoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Synovial Sarcoma:

33
Lymph node, Brain, Cerebellum, Spinal cord, Heart, Smooth muscle, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Adrenal gland, Breast, Uterus, Prostate, Testis, Tonsil, T cells, B cells, Endothelial, Fetal brain, Tongue, Fetal liver, Fetal lung, Trachea, Fetal thyroid

Animal Models for Synovial Sarcoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Synovial Sarcoma

Sources:
51PubMed
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Articles related to Synovial Sarcoma:

(show top 50)    (show all 725)
idTitleAuthorsYear
1
The SYT-SSX fusion protein and histological epithelial differentiation in synovial sarcoma: relationship with extracellular matrix remodeling. (24228088)
2013
2
Expression of FGFR3 and FGFR4 and clinical risk factors associated with progression-free survival in synovial sarcoma. (23664540)
2013
3
NAD(P)H quinone oxidoreductase 1 (NQO1)-bioactivated pronqodine A regulates prostaglandin release from human synovial sarcoma cells. (23425216)
2013
4
Primary monophasic synovial sarcoma of the kidney: a case report and review of literature. (24137053)
2013
5
Synovial sarcoma involving the median nerve: a case report. (23011830)
2012
6
A primary synovial sarcoma of lung. (22655286)
2012
7
Synovial sarcoma arising in the vulva cytogenetically confirmed by SYT break-apart rearrangement fluorescence in situ hybridization: A case report and discussion of diagnostic methods. (23162630)
2012
8
Poorly differentiated synovial sarcoma of the sphenoid sinus: report of the first case and review of synovial sarcomas of the sinonasal tract. (22958201)
2012
9
Biphasic synovial sarcoma arising from superior vena cava. (22419995)
2012
10
SYT-SSX breakpoint peptide vaccines in patients with synovial sarcoma: a study from the Japanese Musculoskeletal Oncology Group. (22726592)
2012
11
Primary cardiac synovial sarcoma. (22458908)
2012
12
Pericardial synovial sarcoma, a potential for misdiagnosis: clinicopathologic and molecular cytogenetic analysis of three cases with literature review. (22180488)
2012
13
Recurrent and novel SS18-SSX fusion transcripts in synovial sarcoma: description of three new cases. (22976541)
2012
14
Of mice and men: opportunities to use genetically engineered mouse models of synovial sarcoma for preclinical cancer therapeutic evaluation. (21666582)
2011
15
Giant primary cardiac synovial sarcoma. (21073528)
2011
16
Synovial sarcoma of the vulva: a case report. (21392384)
2011
17
A case of renal synovial sarcoma treated with adjuvant ifosfamide and doxorubicin. (21804284)
2011
18
Synovial sarcoma of the masticator space: report of a case. (21778013)
2011
19
TLE1 is a robust diagnostic biomarker for synovial sarcomas and correlates with t(X;18): analysis of 319 cases. (20189377)
2010
20
Expression of survivin detected by immunohistochemistry in the cytoplasm and in the nucleus is associated with prognosis of leiomyosarcoma and synovial sarcoma patients. (20181247)
2010
21
Synovial sarcoma of the foot enlightening etiology: a case report. (22530463)
2010
22
Metastatic synovial sarcoma, masquerading a carcinoma from a tonsillar primary: a rare case presentation. (20699542)
2010
23
Downregulation of SS18-SSX1 expression in synovial sarcoma by small interfering RNA enhances the focal adhesion pathway and inhibits anchorage-independent growth in vitro and tumor growth in vivo. (20198325)
2010
24
Primary retropharyngeal synovial sarcoma. (18854438)
2009
25
Growth suppression and apoptosis induction in synovial sarcoma cell lines by a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ). (18760530)
2008
26
Diagnostic accuracy of FISH and RT-PCR in 50 routinely processed synovial sarcomas. (18301245)
2008
27
Primary synovial sarcoma of the abdominal wall: a case report and review of the literature. (23012178)
2008
28
The C terminus of the synovial sarcoma-associated SSX proteins interacts with the LIM homeobox protein LHX4. (17667940)
2008
29
Evaluation of genetic stability of the SYT gene rearrangement by break-apart FISH in primary and xenotransplanted synovial sarcomas. (17175375)
2007
30
MRI findings of prostatic synovial sarcoma. (17267463)
2007
31
Tumor induced hypercalcemia in a patient with mediastinal synovial sarcoma. (17849748)
2007
32
Effect of sinomenine on gene expression of the IL-1 beta-activated human synovial sarcoma. (16566946)
2006
33
Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator. (15919756)
2005
34
Identification of PDZK4, a novel human gene with PDZ domains, that is upregulated in synovial sarcomas. (15077175)
2004
35
Establishment and characterization of a biphasic synovial sarcoma cell line, SYO-1. (14744540)
2004
36
Matrix metalloproteinase-2 expression correlates with morphological and immunohistochemical epithelial characteristics in synovial sarcoma. (11895494)
2002
37
Primary synovial sarcoma of the kidney: a case report with literature review. (12574853)
2001
38
Analysis of transforming activity of human synovial sarcoma-associated chimeric protein SYT-SSX1 bound to chromatin remodeling factor hBRM/hSNF2 alpha. (11274403)
2001
39
Tarsal tunnel syndrome caused by synovial sarcoma. (11437172)
2001
40
Molecular mechanisms underlying human synovial sarcoma development. (11107170)
2001
41
Detection of SYT-SSX fusion transcripts in both epithelial and spindle cell areas of biphasic synovial sarcoma using laser capture microdissection. (10889911)
2000
42
Analysis of SYT-SSX fusion transcripts and bcl-2 expression and phosphorylation status in synovial sarcoma. (10879732)
2000
43
Detection of a variant SYT-SSX1 fusion in a case of predominantly epithelioid synovial sarcoma. (10229776)
1999
44
Nuclear localization of SYT, SSX and the synovial sarcoma-associated SYT-SSX fusion proteins. (9285793)
1997
45
Biphasic synovial sarcoma in the small intestinal mesentery. (7539716)
1995
46
Synovial sarcoma. An immunohistochemical study of the epithelial component. (7514419)
1994
47
The prognostic value of immunohistochemical staining for proliferating cell nuclear antigen in synovial sarcoma. (8100481)
1993
48
Primary biphasic synovial sarcoma of the orbit. (1313455)
1992
49
Synovial sarcoma. Inter-relationship of the biphasic and monophasic subtypes. (1661412)
1991
50
Epithelioid sarcoma and synovial sarcoma in the same knee. (6243238)
1980

Genetic Variations for Synovial Sarcoma

Expression for genes affiliated with Synovial Sarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Synovial Sarcoma

Search GEO for disease gene expression data for Synovial Sarcoma.

Pathways for genes affiliated with Synovial Sarcoma

Sources:
30KEGG
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Pathways related to Synovial Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7SSX1, SS18, SSX2B, SSX2

Compounds for genes affiliated with Synovial Sarcoma

GO Terms for genes affiliated with Synovial Sarcoma

Sources:
16Gene Ontology
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Cellular components related to Synovial Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.0SSX2IP, SSX7, SS18L1, SSX2B, SSX4B, SSX5

Biological processes related to Synovial Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of transcription, DNA-dependentGO:00635510.9SSX7, SSX2B, SSX4B, SSX5, SSX1, SSX3
2transcription, DNA-dependentGO:00635110.6SSX8, SSX6, SSX7, SS18L1, SSX2B, SSX4B

Molecular functions related to Synovial Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleic acid bindingGO:00367610.9SSX8, SSX9, SSX3, SSX1, SSX5, SSX4B

Products for genes affiliated with Synovial Sarcoma

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Sources for Synovial Sarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet