MCID: SYN006
MIFTS: 51

Synovial Sarcoma malady

Cancer diseases category

Summaries for Synovial Sarcoma

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42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Synovial sarcoma is rare and aggressive soft tissue sarcoma that appears as deep, painless, slowly growing masses. most frequently the tumor affects the legs, especially the knees, and the arms. less frequently, this disease develops in the trunk, head and neck region, or the abdomen. although synovial sarcoma does not have a clearly defined cause, genetic factors are believed to influence the development of this disease. cells in these tumors are usually characterized by the presence of a translocation involving chromosomes x and 18. this translocation is specific to synovial sarcoma and is often used to diagnose this cancer. although this condition generally affects adults, about 30% of reported cases occur in children and adolescents. last updated: 7/11/2011

MalaCards: Synovial Sarcoma, also known as sarcoma, synovial, is related to sarcoma and hemangiopericytoma. An important gene associated with Synovial Sarcoma is SSX2 (synovial sarcoma, X breakpoint 2), and among its related pathways is Transcriptional misregulation in cancer. Affiliated tissues include lung, kidney and bone.

Wikipedia:63 A synovial sarcoma (also known as: malignant synovioma) is a rare form of cancer which usually occurs... more...

Description from OMIM:46 312820,300813

Aliases & Classifications for Synovial Sarcoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 9diseasecard, 46OMIM, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
synovial sarcoma:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

synovial sarcoma 8 42 10 48 60
sarcoma, synovial 9 46
sarcoma synovial 44
synovialosarcoma 48


External Ids:

Disease Ontology8 DOID:5485
NCIt39 C3400
MeSH34 D013584
SNOMED-CT56 63211008, 302851001
SNOMED-CT via Orphanet57 63211008, 302851001
ICD10 via Orphanet26 C49.9

Related Diseases for Synovial Sarcoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Synovial Sarcoma:



Diseases related to synovial sarcoma

Clinical Features for Synovial Sarcoma

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46OMIM
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Clinical features from OMIM:

312820,300813

Drugs & Therapeutics for Synovial Sarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Synovial Sarcoma

Drug clinical trials:

Search ClinicalTrials for Synovial Sarcoma

Search NIH Clinical Center for Synovial Sarcoma

Search CenterWatch for Synovial Sarcoma

Genetic Tests for Synovial Sarcoma

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Anatomical Context for Synovial Sarcoma

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32MalaCards
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MalaCards organs/tissues related to Synovial Sarcoma:

32
Lung, Kidney, Bone, Breast, Heart, Tongue, Thyroid, Prostate, Spinal cord, Small intestine, Liver, Tonsil, Pancreas, Colon, Smooth muscle, Endothelial, Testis, Testes, Cerebellum, Uterus, Lymph node, Brain, Trachea

Animal Models for Synovial Sarcoma or affiliated genes

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Publications for Synovial Sarcoma

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50PubMed
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Articles related to Synovial Sarcoma:

(show top 50)    (show all 725)
idTitleAuthorsYear
1
Primary giant mediastinal synovial sarcoma of the neck: A case report and review of the literature. (24348836)
2014
2
Transoral robotic resection of oropharyngeal synovial sarcoma in a pediatric patient. (23639341)
2013
3
Factors influencing survival in metastatic synovial sarcoma: importance of patterns of metastases and the first-line chemotherapy regimen. (23780657)
2013
4
Pericardial synovial sarcoma: a case report and review of the literature. (24022581)
2013
5
SNAP-23 and VAMP-3 contribute to the release of IL-6 and TNFI+ from a human synovial sarcoma cell line. (24373201)
2013
6
Primary Cardiac Synovial Sarcoma Arising from the Pulmonary Valve. (24266840)
2013
7
A rare synovial sarcoma of the spine in the thoracic vertebral body. (24232695)
2013
8
The clinical implication of SS18-SSX fusion gene in synovial sarcoma. (24022186)
2013
9
Primary synovial sarcoma of the uterus. (21491161)
2012
10
Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines. (22213202)
2012
11
Synovial sarcoma of the buttocks presenting with a non-healing wound and rapid progression after local resection: a case report. (22741534)
2012
12
Pathological fracture of femur secondary to infected synovial sarcoma. (23175020)
2012
13
Malignant gastrointestinal neuroectodermal tumor showing overlapped immunophenotype with synovial sarcoma: CD99 and SOX10 antibodies are useful in differential diagnosis. (23154774)
2012
14
Primary renal synovial sarcoma. (22606625)
2011
15
Identification of altered MicroRNA expression patterns in synovial sarcoma. (21213367)
2011
16
Primary cardiac synovial sarcoma: a case report and literature review. (21355957)
2011
17
Primary renal synovial sarcoma in a 13-year-old boy. (21930002)
2011
18
Sparing strategy does not compromise prognosis in pediatric localized synovial sarcoma: experience of the International Society of Pediatric Oncology, Malignant Mesenchymal Tumors (SIOP-MMT) Working Group. (21495161)
2011
19
Free jejunal transfer for a 15-year-old girl with synovial sarcoma of the hypopharynx. (21236741)
2011
20
Diagnostic utility of dual-color break-apart chromogenic in situ hybridization for the detection of rearranged SS18 in formalin-fixed, paraffin-embedded synovial sarcoma. (20594581)
2010
21
Clinicopathologic analysis of 4 cases of primary renal synovial sarcoma. (20109354)
2010
22
Pediatric synovial sarcoma of the sacrum: a case report. (19952797)
2010
23
Primary synovial sarcoma of kidney-a report of 2 cases and review of literature. (21863065)
2010
24
Synovial sarcoma in childhood and adolescence: a retrospective series of 77 patients registered by the Children's Cancer and Leukaemia Group between 1991 and 2006. (20213848)
2010
25
Risk assessment based on FDG-PET imaging in patients with synovial sarcoma. (19048352)
2009
26
Synovial sarcoma presenting as a parotid mass: case report and review of literature. (18327782)
2008
27
Intracranial metastasis from synovial sarcoma. (19292263)
2008
28
Primary synovial sarcoma arising in the parotid region diagnosed by fluorescence in situ hybridization. (18262374)
2008
29
Synovial sarcoma of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 10 cases. (18223331)
2008
30
Modeling synovial sarcoma: timing is everything. (17418406)
2007
31
Molecular characterization of a novel variant of a SYT-SSX1 fusion transcript in synovial sarcoma. (17880539)
2007
32
Synovial sarcoma of the extremities: prognostic factors for 20 nonmetastatic cases and a new histologic grading system with prognostic significance. (17072434)
2006
33
Myxoid monophasic synovial sarcoma: case report of an unusual histological variant. (16918143)
2006
34
Pathology quiz case 1. Epithelioid synovial sarcoma (synoviosarcoma). (17116828)
2006
35
Characteristic sequence motifs located at the genomic breakpoints of the translocation t(X;18) in synovial sarcomas. (12687023)
2003
36
APC mutations in synovial sarcoma. (11920741)
2002
37
Synovial sarcoma arising from the pleura: a case report with ultrastructural and immunohistological studies. (12181652)
2002
38
Clinical impact of molecular and cytogenetic findings in synovial sarcoma. (11433527)
2001
39
Primary synovial sarcoma of the kidney. (10935650)
2000
40
Association of SYT-SSX fusion types with proliferative activity and prognosis in synovial sarcoma. (10824918)
2000
41
Synovial sarcoma, histologically mimicking primitive neuroectodermal tumor/Ewing's sarcoma at distant sites. (10563198)
1999
42
Pathologic quiz case. Pulmonary mass in a patient presenting with a hemothorax. Diagnosis: primary pulmonary biphasic synovial sarcoma. (10583938)
1999
43
Expression of smooth muscle calponin in synovial sarcoma. (18521272)
1999
44
Synovial sarcoma of the pericardium]. (9885009)
1998
45
The SSX-2 gene, which is involved in the t(X;18) translocation of synovial sarcomas, codes for the human tumor antigen HOM-MEL-40. (8840996)
1996
46
Interphase fluorescence in situ hybridization and reverse transcription polymerase chain reaction as a diagnostic aid for synovial sarcoma. (8579118)
1996
47
Distinct Xp11.2 breakpoint regions in synovial sarcoma revealed by metaphase and interphase FISH: relationship to histologic subtypes. (8174096)
1994
48
Sublocalization of the synovial sarcoma-associated t(X;18) chromosomal breakpoint in Xp11.2 using cosmid cloning and fluorescence in situ hybridization. (8389029)
1993
49
Epithelioid monophasic synovial sarcoma. (8266594)
1993
50
Fine needle aspiration cytology of biphasic synovial sarcoma of soft tissue. Report of a case with ultrastructural, immunohistologic and cytophotometric studies. (2296842)
1990

Genetic Variations for Synovial Sarcoma

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Expression for genes affiliated with Synovial Sarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Synovial Sarcoma

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Pathways for genes affiliated with Synovial Sarcoma

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29KEGG
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Pathways related to Synovial Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7SSX1, SS18, SSX2B, SSX2

Compounds for genes affiliated with Synovial Sarcoma

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GO Terms for genes affiliated with Synovial Sarcoma

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16Gene Ontology
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Cellular components related to Synovial Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.0SSX2IP, SSX7, SS18L1, SSX2B, SSX4B, SSX5

Biological processes related to Synovial Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of transcription, DNA-dependentGO:00635510.9SSX7, SSX2B, SSX4B, SSX5, SSX1, SSX3
2transcription, DNA-dependentGO:00635110.6SSX8, SSX6, SSX7, SS18L1, SSX2B, SSX4B

Molecular functions related to Synovial Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleic acid bindingGO:00367610.9SSX8, SSX9, SSX3, SSX1, SSX5, SSX4B

Products for genes affiliated with Synovial Sarcoma

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Sources for Synovial Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet