MCID: SYN007
MIFTS: 58

Synovitis malady

Summaries for Synovitis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A connective tissue disease that results in inflammation located in synovial membrane that lines a synovial joint which causes pain and swelling.

MalaCards: Synovitis, also known as synovitis nos, is related to pigmented villonodular synovitis and arthritis. An important gene associated with Synovitis is MMP1 (matrix metallopeptidase 1 (interstitial collagenase)), and among its related pathways are Osteoclast differentiation and PI3K-Akt signaling pathway. The compounds paraffin and creatinine have been mentioned in the context of this disorder. Affiliated tissues include synovial membrane, bone marrow and whole blood, and related mouse phenotypes are immune system and skeleton.

Wikipedia:64 Synovitis is the medical term for inflammation of the synovial membrane. This membrane lines joints... more...

Aliases & Classifications for Synovitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
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Related Diseases for Synovitis

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Synovitis family:

synovitis, chronic

Diseases related to Synovitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 259)
idRelated DiseaseScoreTop Affiliating Genes
1pigmented villonodular synovitis31.7PDGFRB, LAPTM5, MOAP1, CSF1R, CSF1, ATP6V1B2
2arthritis31.3ACP5, MMP9, MMP1, TNFRSF11B, TNFSF11, CSF1
3osteoarthritis30.9PTHLH, BGLAP, SPP1, MMP9, MMP1, CD68
4psoriatic arthritis30.4MMP1, TNFRSF11B, TNFSF11
5arthropathy30.2MMP1, TNFRSF11B, TNFSF11
6osteonecrosis29.9BGLAP
7rheumatic disease29.9TNFRSF11B, BGLAP, TNFSF11
8secondary syphilis29.7SPP1, PTHLH, ACP5, TNFSF11, TNFRSF11B, CSF1
9adenocarcinoma29.7SPP1, PTHLH, TNFSF11, IBSP, PDGFRB, MMP9
10squamous cell carcinoma29.7PTHLH, CSF1R, MMP1, SPP1, MMP9, IBSP
11multicentric reticulohistiocytosis29.7CD68
12ankylosing spondylitis29.7BGLAP, TNFRSF11B, TNFSF11
13osteopetrosis autosomal dominant type 229.7TNFSF11, BGLAP
14villonodular synovitis11.2
15acne10.6
16synovitis, chronic10.6
17sapho syndrome10.6
18polymyalgia rheumatica10.3
19tenosynovial giant cell tumor10.3
20hemarthrosis10.2
21transient arthritis10.2
22gonococcal synovitis10.2
23septic arthritis10.2
24gout10.1
25reactive arthritis10.1
26n syndrome10.1
27tuberculosis10.1
28synovial chondromatosis10.1
29carpal tunnel syndrome10.1
30pseudogout10.1
31syphilis10.1
32char syndrome10.1
33eosinophilic fasciitis10.1
34spondylarthropathy10.1
35talo-patello-scaphoid osteolysis, synovitis, and short fourth metacarpals10.1
36osteosarcoma10.0MMP9, SPP1, BGLAP, IBSP, PDGFRB, CSF1R
37rheumatoid arthritis10.0BGLAP, SPP1, IBSP, CSF1, TNFRSF11B, CD68
38melanoma10.0CSF1, PDGFRB, TNFSF11, TNFRSF11B, CD68, SPP1
39breast cancer10.0CSF1, IBSP, TNFRSF11B, MMP1, CALCR, TNFSF11
40myeloma10.0SPP1, IBSP, ACP5, TNFSF11, CALCR, PTHLH
41osteoporosis10.0BGLAP, CALCR, CSF1, SPP1, TNFSF11, PTHLH
42bone carcinoma10.0SPP1, PTHLH, MMP9, TNFRSF11B, TNFSF11, PDGFRB
43atherosclerosis10.0TNFRSF11B, PDGFRB, IBSP, CD68, MMP9, MMP1
44chronic kidney failure10.0SPP1, PTHLH, ACP5, TNFRSF11B, IBSP, BGLAP
45osteoporosis, postmenopausal10.0ACP5, BGLAP, IBSP, TNFSF11, TNFRSF11B, PTHLH
46hypercalcemia10.0TNFRSF11B, BGLAP, CALCR, CSF1, PTHLH, TNFSF11
47hyperparathyroidism10.0ACP5, TNFRSF11B, TNFSF11, BGLAP, PTHLH
48giant cell tumor10.0TNFSF11, TNFRSF11B, CSF1, MMP9, BGLAP
49kidney cancer10.0PDGFRB, CSF1R, CSF1, MMP9, PTHLH, SPP1
50osteopetrosis10.0TNFSF11, CSF1, BGLAP, TNFRSF11B

Graphical network of the top 20 diseases related to Synovitis:



Diseases related to synovitis

Clinical Features for Synovitis

Drugs & Therapeutics for Synovitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Synovitis

Drug clinical trials:

Search ClinicalTrials for Synovitis

Search NIH Clinical Center for Synovitis

Search CenterWatch for Synovitis

Genetic Tests for Synovitis

Anatomical Context for Synovitis

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Synovitis:

33
Bone marrow, Whole blood, Spinal cord, Skeletal muscle, Lung, Breast, Skin, Prostate, Monocytes, T cells, B cells, Endothelial, Dorsal root ganglion

FMA organs/tissues related to Synovitis:

14
Synovial membrane

Animal Models for Synovitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Synovitis

Sources:
51PubMed
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Articles related to Synovitis:

(show top 50)    (show all 1036)
idTitleAuthorsYear
1
Pigmented villonodular synovitis of the ankle: an anterior-posterior technique for excision. (22134437)
2013
2
Lamellated hyperintense synovitis: potential MR imaging sign of an infected knee arthroplasty. (23091176)
2013
3
SAPHO (synovitis-acne-pustulosis-hyperostosis-osteitis): a multidisciplinary approach. (24237723)
2013
4
Adult multifocal pigmented villonodular synovitis--clinical review. (23361936)
2013
5
Severe inflammation associated with synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome was markedly ameliorated by single use of minocycline. (23397374)
2013
6
Low-dose external beam radiotherapy as a postoperative treatment for patients with diffuse pigmented villonodular synovitis of the knee: 4 recurrences in 23 patients followed for mean 9 years. (22489888)
2012
7
Chondroblastoma of the femoral neck as a cause of hip synovitis. (21685802)
2012
8
Remitting seronegative symmetrical synovitis with pitting edema syndrome in a chronic hemodialysis patient. (22431931)
2012
9
Long-term outcome of the treatment of high-risk tenosynovial giant cell tumor/pigmented villonodular synovitis with radiotherapy and surgery. (22281719)
2012
10
Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis. (21823110)
2012
11
Experimental arthritis: Targeting EGFR to fight synovitis. (22450555)
2012
12
The rate of polymyalgia rheumatica (PMR) and remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome in a clinic where primary care physicians are working in Japan. (21431946)
2012
13
Osteoarthritis. Omega-3 fatty acids and synovitis in osteoarthritic knees. (22508432)
2012
14
Associations between MRI-defined synovitis, bone marrow lesions and structural features and measures of pain and physical function in hand osteoarthritis. (22121126)
2012
15
Rheumatoid factor-positive synovitis in a patient with C3 deficiency. (23043374)
2012
16
Destructive synovial hemangioma of the hip resembling pigmented villonodular synovitis. (20570091)
2011
17
Do non-steroidal anti-inflammatory drugs have a significant effect on detection and grading of ultrasound-detected synovitis in patients with rheumatoid arthritis? Results from a randomised study. (21803749)
2011
18
Ultrasound in rheumatoid arthritis: volar versus dorsal synovitis evaluation and scoring. (21635793)
2011
19
Polymyalgia rheumatica is associated with extensor tendon tenosynovitis but not with synovitis of the hands: a magnetic resonance imaging study. (21071481)
2011
20
Validity of ultrasonography and measures of adult shoulder function and reliability of ultrasonography in detecting shoulder synovitis in patients with rheumatoid arthritis using magnetic resonance imaging as a gold standard. (20235183)
2010
21
Septic arthritis or transient synovitis of the hip in children: the value of clinical prediction algorithms. (20798450)
2010
22
Semiquantitative assessment of synovitis in osteoarthritis on non contrast-enhanced MRI. (19070515)
2009
23
A rare case of pigmented villonodular synovitis after unicompartmental knee replacement: a case report. (20062713)
2009
24
Liposome-based diclofenac for the treatment of inflammation in an acute synovitis model in horses. (19000279)
2008
25
(18) F-FDG PET imaging of rheumatoid articular and extraarticular synovitis. (18838912)
2008
26
Localized pigmented villonodular synovitis in the knee associated with locking symptoms. (17945499)
2008
27
Synovial angiostatic non-ELR CXC chemokines in inflammatory arthritides: does CXCL4 designate chronicity of synovitis? (17265155)
2007
28
Pigmented villonodular synovitis of the foot and ankle: Forty years of experience from the Scottish bone tumor registry. (16949531)
2006
29
Pigmented villonodular synovitis of the hip mimicking soft-tissue sarcoma: a case report. (16598093)
2006
30
Membrane-associated IL-1 contributes to chronic synovitis and cartilage destruction in human IL-1 alpha transgenic mice. (14688369)
2004
31
Pigmented villonodular synovitis of the ankle occurring in a patient on anticoagulation therapy. (15691183)
2004
32
Recurrent and non-recurrent pigmented villonodular synovitis 1. (12594386)
2002
33
Pigmented villonodular synovitis of the knee: average five-year follow-up of arthroscopic treatment. (12741588)
2002
34
Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis). (11079016)
2000
35
Idiopathic pseudoaneurysm of the dorsalis pedis artery mimicking pigmented villonodular synovitis. (9921772)
1999
36
Pigmented villonodular synovitis of the elbow: a case report and literature review. (10194026)
1999
37
Diffuse pigmented villonodular synovitis of the knee associated with chronic ACL deficiency. (9606698)
1998
38
Sonography of pigmented villonodular synovitis in the ankle joint. (9502041)
1998
39
Malignancy in pigmented villonodular synovitis. (9730332)
1998
40
Pigmented villonodular synovitis of the temporomandibular joint. (9158403)
1997
41
Pigmented villonodular synovitis. (8633118)
1996
42
Spinal pigmented villonodular synovitis: a case report. (8852323)
1996
43
Progression from simple joint effusion to extensive pigmented villonodular synovitis of the hip within 2 years: demonstration with MR imaging. (7645515)
1995
44
Inflammatory microcrystals differentially regulate the secretion of macrophage inflammatory protein 1 and interleukin 8 by human neutrophils: a possible mechanism of neutrophil recruitment to sites of inflammation in synovitis. (7500047)
1995
45
Gadolinium-enhanced MRI of pigmented villonodular synovitis of the knee. (1430457)
1992
46
Localized pigmented villonodular synovitis of the knee. Arthroscopic treatment. (1914300)
1991
47
Osteomyelitis and synovitis produced by Mycobacterium marinum in a fisherman. (2254433)
1990
48
Pigmented villonodular synovitis of the talus in a child. (3229701)
1988
49
Magnetic resonance imaging in the diagnosis of aggressive villonodular synovitis. (3052980)
1988
50
Intermittent hydrarthrosis; periodic benign synovitis. (13567199)
1958

Genetic Variations for Synovitis

Expression for genes affiliated with Synovitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Synovitis

Search GEO for disease gene expression data for Synovitis.

Pathways for genes affiliated with Synovitis

Sources:
30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN
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Compounds for genes affiliated with Synovitis

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB
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Compounds related to Synovitis according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1paraffin4511.4PTHLH, CSF1, CSF1R, PDGFRB, IBSP, BGLAP
2creatinine4511.4TNFRSF11B, PTHLH, ACP5, MMP9, MMP1, TNFSF11
3vegf4511.3SPP1, MMP9, MMP1, TNFSF11, CSF1, CSF1R
41,25 dihydroxy vitamin d34511.3TNFRSF11B, PTHLH, ACP5, TNFSF11, CSF1, CSF1R
5calcitriol45 60 11 2414.3BGLAP, CALCR, MMP1, PDGFRB, CSF1, TNFSF11
6cysteine4511.3MMP9, MMP1, IBSP, TNFRSF11B, TNFSF11, BGLAP
7vitamin d4511.3CALCR, SPP1, PTHLH, ACP5, TNFRSF11B, PDGFRB
8dexamethasone45 50 29 1114.3TNFSF11, MMP9, ACP5, BGLAP, TNFRSF11B, SPP1
9phosphatidylinositol4511.3CSF1, SPP1, TNFRSF11B, MMP9, PTHLH, CSF1R
10zoledronic acid4511.2BGLAP, IBSP, TNFRSF11B, MMP1, PTHLH, TNFSF11
11testosterone45 60 11 2414.2MMP9, SPP1, PTHLH, MMP1, PDGFRB, TNFRSF11B
12hydroxyproline45 11 2413.2MMP9, BGLAP, TNFRSF11B, ACP5, PTHLH, MMP1
13hydroxyapatite4511.2PTHLH, SPP1, ACP5, TNFRSF11B, TNFSF11, IBSP
14tgf beta14511.2CSF1, PDGFRB, PTHLH, SPP1, MMP9, MMP1
15tartrate4511.2TNFSF11, CSF1, CALCR, BGLAP, ACP5, PTHLH
16cyclosporin a45 29 6013.1TNFSF11, CALCR, BGLAP, TNFRSF11B, MMP9, MMP1
17titanium4511.1IBSP, BGLAP, SPP1, ACP5, TNFRSF11B, TNFSF11
18ns 39845 6012.1MMP9, TNFRSF11B, TNFSF11, CSF1, BGLAP, MMP1
1925-hydroxyvitamin d4511.1BGLAP, TNFSF11, PTHLH, SPP1, TNFRSF11B, ACP5
20tyrosine4511.1ACP5, MMP9, TNFRSF11B, TNFSF11, CSF1, SPP1
21phosphorus4511.1TNFSF11, PTHLH, BGLAP, SPP1, ACP5, TNFRSF11B
22clodronate45 50 1113.1TNFSF11, MMP1, ACP5, PTHLH, TNFRSF11B
23ascorbic acid45 2412.1MMP1, TNFRSF11B, SPP1, TNFSF11, CSF1, IBSP
24pamidronate45 50 1113.1MMP1, PTHLH, TNFSF11, TNFRSF11B, BGLAP
25pyridinoline4511.1ACP5, PTHLH, TNFRSF11B, IBSP, BGLAP
26heparin45 29 11 2414.1IBSP, SPP1, BGLAP, ACP5, TNFRSF11B, TNFSF11
27deoxypyridinoline4511.1TNFSF11, BGLAP, IBSP, TNFRSF11B, ACP5
28alendronate45 50 1113.0BGLAP, MMP1, TNFRSF11B, TNFSF11, PTHLH
29serine4511.0MMP1, TNFRSF11B, TNFSF11, CSF1, BGLAP, CSF1R
30pd 98,0594511.0CSF1R, CSF1, TNFSF11, MMP1, IBSP, SPP1
31procollagen4511.0TNFSF11, ACP5
32estradiol45 11 2413.0IBSP, CALCR, PTHLH, ACP5
33ibandronate45 1112.0TNFSF11, TNFRSF11B, IBSP, BGLAP
34infliximab45 50 1113.0SPP1, MMP1, TNFRSF11B, BGLAP, TNFSF11
35retinoic acid45 2412.0PDGFRB, SPP1, PTHLH, MMP9, MMP1, BGLAP
36matrigel4511.0PTHLH, PDGFRB, MMP1, IBSP
37pge24511.0MMP9
38genistein45 29 60 2 11 2415.9MMP9, SPP1, TNFRSF11B, TNFSF11, MMP1, PDGFRB
39vitamin k24510.9BGLAP, CSF1, TNFRSF11B, TNFSF11
40cycloheximide4510.9CSF1R, IBSP
41rantes4510.9CALCR, CSF1, ACP5
42celecoxib45 60 29 50 11 2415.9MMP1, CSF1, MMP9, TNFRSF11B, TNFSF11
43prostaglandin4510.9TNFRSF11B, CSF1, TNFSF11, MMP1
44geranylgeranyl pyrophosphate4510.9TNFSF11, TNFRSF11B, MMP9, MMP1
45azathioprine45 50 2 1113.8TNFSF11, TNFRSF11B, ACP5, PTHLH, BGLAP
46prednisolone45 29 1112.7BGLAP, TNFRSF11B, MMP1, PTHLH, CSF1
47etanercept45 50 1112.6TNFSF11, MMP1, CSF1, TNFRSF11B
48indomethacin45 60 29 1113.6SPP1, CSF1
49sb 20358045 6011.6SPP1, MMP9, MMP1, TNFRSF11B, TNFSF11, BGLAP
50troglitazone45 29 60 1113.4MMP1, SPP1, PTHLH, MMP9, CSF1

GO Terms for genes affiliated with Synovitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.7SPP1, PVR, BGLAP, CSF1, TNFSF11, TNFRSF11B
2membrane-bounded vesicleGO:03198810.5SPP1, BGLAP
3extracellular regionGO:00557610.5BGLAP, IBSP, TNFSF11, TNFRSF11B, MMP1, MMP9

Biological processes related to Synovitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019810.9IBSP, TNFRSF11B, MMP1, MMP9, SPP1
2macrophage differentiationGO:03022510.8MMP9, CSF1, CSF1R
3osteoclast differentiationGO:03031610.8TNFSF11, CSF1, CSF1R
4skeletal system developmentGO:00150110.8BGLAP, TNFRSF11B, MMP9, PTHLH
5osteoclast proliferationGO:00215810.7TNFSF11, CSF1
6regulation of bone resorptionGO:04512410.6CSF1R, BGLAP
7ossificationGO:00150310.6IBSP, CSF1, TNFSF11
8positive regulation of bone resorptionGO:04578010.6SPP1, TNFSF11
9phosphatidylinositol metabolic processGO:04648810.5CSF1R, PDGFRB
10response to vitamin DGO:03328010.2SPP1, BGLAP

Molecular functions related to Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.6SPP1, TNFRSF11B, TNFSF11, CSF1

Products for genes affiliated with Synovitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Synovitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet