MCID: SYN007
MIFTS: 59

Synovitis malady

Summaries for Synovitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A connective tissue disease that results in inflammation located in synovial membrane that lines a synovial joint which causes pain and swelling.

MalaCards: Synovitis, also known as synovitis nos, is related to pigmented villonodular synovitis and arthritis. An important gene associated with Synovitis is MMP1 (matrix metallopeptidase 1 (interstitial collagenase)), and among its related pathways are Osteoclast differentiation and PI3K-Akt signaling pathway. The compounds paraffin and creatinine have been mentioned in the context of this disorder. Affiliated tissues include synovial membrane, bone and t cells, and related mouse phenotypes are immune system and skeleton.

Wikipedia:63 Synovitis is the medical term for inflammation of the synovial membrane. This membrane lines joints... more...

Aliases & Classifications for Synovitis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Related Diseases for Synovitis

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17GeneCards, 18GeneDecks
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Diseases in the Synovitis family:

Synovitis, Chronic

Diseases related to Synovitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 267)
idRelated DiseaseScoreTop Affiliating Genes
1pigmented villonodular synovitis31.7PDGFRB, LAPTM5, MOAP1, CSF1R, CSF1, ATP6V1B2
2arthritis31.3ACP5, MMP9, MMP1, TNFRSF11B, TNFSF11, CSF1
3rheumatoid arthritis31.2BGLAP, SPP1, IBSP, CSF1, TNFRSF11B, CD68
4hyperostosis30.9BGLAP
5osteoarthritis30.8PTHLH, BGLAP, SPP1, MMP9, MMP1, CD68
6giant cell tumor30.7TNFSF11, TNFRSF11B, CSF1, MMP9, BGLAP
7osteomyelitis30.5IBSP, TNFSF11, ACP5
8psoriatic arthritis30.4MMP1, TNFRSF11B, TNFSF11
9sarcoma30.2CSF1, CSF1R, PDGFRB
10arthropathy30.2MMP1, TNFRSF11B, TNFSF11
11osteonecrosis29.9BGLAP
12osteosarcoma29.7MMP9, SPP1, BGLAP, IBSP, PDGFRB, CSF1R
13melanoma29.7CSF1, PDGFRB, TNFSF11, TNFRSF11B, CD68, SPP1
14secondary syphilis29.7SPP1, PTHLH, ACP5, TNFSF11, TNFRSF11B, CSF1
15adenocarcinoma29.7SPP1, PTHLH, TNFSF11, IBSP, PDGFRB, MMP9
16leukemia29.7PDGFRB, CSF1R, CSF1, CALCR, ACP5
17diabetes mellitus29.7BGLAP, MMP9
18squamous cell carcinoma29.7PTHLH, CSF1R, MMP1, SPP1, MMP9, IBSP
19multicentric reticulohistiocytosis29.7CD68
20ankylosing spondylitis29.7BGLAP, TNFRSF11B, TNFSF11
21osteopetrosis autosomal dominant type 229.7TNFSF11, BGLAP
22villonodular synovitis11.1
23acne10.6
24sapho syndrome10.5
25polymyalgia rheumatica10.3
26tenosynovial giant cell tumor10.3
27hemarthrosis10.2
28transient arthritis10.2
29gonococcal synovitis10.1
30septic arthritis10.1
31pigmentation disease10.1
32reactive arthritis10.1
33malignant giant cell tumor10.1
34neuropathy10.1
35tuberculosis10.1
36carpal tunnel syndrome10.0
37lipoma10.0
38psoriasis10.0
39syphilis10.0
40talo-patello-scaphoid osteolysis, synovitis, and short fourth metacarpals10.0
41breast cancer10.0CSF1, IBSP, TNFRSF11B, MMP1, CALCR, TNFSF11
42myeloma10.0SPP1, IBSP, ACP5, TNFSF11, CALCR, PTHLH
43osteoporosis10.0BGLAP, CALCR, CSF1, SPP1, TNFSF11, PTHLH
44bone carcinoma10.0SPP1, PTHLH, MMP9, TNFRSF11B, TNFSF11, PDGFRB
45atherosclerosis10.0TNFRSF11B, PDGFRB, IBSP, CD68, MMP9, MMP1
46chronic kidney failure10.0SPP1, PTHLH, ACP5, TNFRSF11B, IBSP, BGLAP
47osteoporosis, postmenopausal10.0ACP5, BGLAP, IBSP, TNFSF11, TNFRSF11B, PTHLH
48hypercalcemia10.0TNFRSF11B, BGLAP, CALCR, CSF1, PTHLH, TNFSF11
49hyperparathyroidism10.0ACP5, TNFRSF11B, TNFSF11, BGLAP, PTHLH
50kidney cancer10.0PDGFRB, CSF1R, CSF1, MMP9, PTHLH, SPP1

Graphical network of the top 20 diseases related to Synovitis:



Diseases related to synovitis

Clinical Features for Synovitis

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Drugs & Therapeutics for Synovitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Synovitis

Drug clinical trials:

Search ClinicalTrials for Synovitis

Search NIH Clinical Center for Synovitis

Search CenterWatch for Synovitis

Genetic Tests for Synovitis

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Anatomical Context for Synovitis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Synovitis:

32
Bone, T cells, Endothelial, Bone marrow, B cells, Testes, Skin, Prostate, Breast, Monocytes, Lung, Spinal cord

FMA organs/tissues related to Synovitis:

14
Synovial membrane

Animal Models for Synovitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Synovitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.1PVR, CALCR, PDGFRB, CSF1R, CSF1, TNFSF11
2MP:000539011.0SPP1, IBSP, CALCR, CSF1R, CSF1, TNFSF11
3MP:000539710.9CALCR, PDGFRB, CSF1R, CSF1, TNFSF11, TNFRSF11B
4MP:000537610.8CSF1R, PDGFRB, CALCR, PVR, CSF1, TNFSF11
5MP:000538210.7PTHLH, TNFRSF11B, TNFSF11, CSF1, CSF1R, PDGFRB
6MP:000537110.7CSF1R, CSF1, ACP5
7MP:001077110.3CSF1R, TNFSF11, MMP9, SPP1

Publications for Synovitis

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50PubMed
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Articles related to Synovitis:

(show top 50)    (show all 1036)
idTitleAuthorsYear
1
Analysis of subclinical synovitis detected by ultrasonography and low-field magnetic resonance imaging in patients with rheumatoid arthritis. (24261760)
2014
2
Haemophilic synovitis of the elbow: radiosynovectomy, open synovectomy or arthroscopic synovectomy? (23786892)
2013
3
Quality of life and health care use in patients with arthralgias without synovitis is similar to that of patients diagnosed with early RA: Data from an early arthritis cohort. (23982959)
2013
4
Contrast-enhanced whole body joint MR imaging in rheumatoid patients on tumour necrosis factor-alpha agents: a pilot study to evaluate novel scoring system for MR synovitis. (23190694)
2013
5
What is the clinical course of transient synovitis in children: a systematic review of the literature. (24229447)
2013
6
Ultrasound-detected synovial abnormalities are frequent in clinically inactive juvenile idiopathic arthritis, but do not predict a flare of synovitis. (22736098)
2013
7
Synovitis of the wrist joint caused by an intraarticular perforation of an osteoid osteoma of the scaphoid. (23162159)
2012
8
Evaluation of the inflammatory response in experimentally induced synovitis in the horse: a comparison of recombinant equine interleukin 1 beta and lipopolysaccharide. (22917743)
2012
9
T cell protein tyrosine phosphatase deficiency results in spontaneous synovitis and subchondral bone resorption in mice. (21968903)
2012
10
Ultrasound Doppler score correlates with OMERACT RAMRIS bone marrow oedema and synovitis score in the wrist joint of patients with rheumatoid arthritis. (21259184)
2012
11
Quantification of synovitis in the cranio-cervical region: dynamic contrast enhanced and diffusion weighted magnetic resonance imaging in early rheumatoid arthritis--a feasibility follow up study. (22578877)
2012
12
Cerebral activation during unilateral clenching in patients with temporomandibular joint synovitis and biting pain: an functional magnetic resonance imaging study. (21933616)
2011
13
The use of CRP within a clinical prediction algorithm for the differentiation of septic arthritis and transient synovitis in children. (22058311)
2011
14
Protracted synovitis without systemic manifestations in familial Mediterranean fever (FMF). (20868584)
2010
15
Angiogenesis and the persistence of inflammation in a rat model of proliferative synovitis. (20309868)
2010
16
Reversible severe synovitis associated with everolimus. (20188596)
2010
17
Fluctuating mixed-type hearing loss associated with synovitis-acne-pustulosis-hyperostosis-osteomyelitis (SAPHO) syndrome. (19864094)
2010
18
Comparison of clinical versus ultrasound-determined synovitis in juvenile idiopathic arthritis. (19877100)
2009
19
Reactive synovitis following hip resurfacing: a case presentation. (18924079)
2008
20
Management of chronic synovitis in patients with hemophilia: with special reference to developing countries. (23100954)
2008
21
Antiinflammatory mediator lipoxin A4 and its receptor in synovitis of patients with rheumatoid arthritis. (17918787)
2007
22
Translocation and expression of CSF1 in pigmented villonodular synovitis, tenosynovial giant cell tumor, rheumatoid arthritis and other reactive synovitides. (17527089)
2007
23
Molecular markers of cartilage breakdown and synovitis at baseline as predictors of structural progression of hip osteoarthritis. The ECHODIAH Cohort. (16322084)
2006
24
Conundrums in nosology: synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome and spondylarthritis. (16874770)
2006
25
Analysis of chromosomal imbalances by comparative genomic hybridisation of pigmented villonodular synovitis. (15766598)
2005
26
Pigmented villonodular synovitis of the temporomandibular joint. (16077324)
2005
27
Pigmented villonodular synovitis of the temporomandibular joint: differential diagnosis and case report. (14706302)
2004
28
New strategies to control inflammatory synovitis: interleukin 15 and beyond. (14532150)
2003
29
Interleukin-6, soluble interleukin-2 receptor and soluble interleukin-6 receptor in the sera of patients with different histological patterns of rheumatoid synovitis. (12673891)
2003
30
Localized pigmented villonodular synovitis in an unusual location in the knee. (12579146)
2003
31
Extraarticular pigmented villonodular synovitis: a cause for failed knee arthroscopy. (12439277)
2002
32
Pigmented villonodular synovitis of the elbow in a 6-year-old girl. (12070502)
2002
33
Methotrexate inhibits rheumatoid synovitis by inducing apoptosis. (11508582)
2001
34
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
35
Diffuse chronic sclerosing osteomyelitis and the synovitis, acne, pustolosis, hyperostosis, osteitis (SAPHO) syndrome in two sisters. (10691145)
2000
36
Villonodular synovitis of the shoulder. (10917253)
2000
37
Pigmented villonodular synovitis. (9602788)
1998
38
Localized pigmented villonodular synovitis of the knee: arthroscopic treatment. (9788377)
1998
39
Quiz case of the month. Intra-articular pigmented villonodular synovitis of the knee. (9724450)
1998
40
Pigmented villonodular synovitis in a child. (8301505)
1993
41
Augmentation of interleukin-1 induced prostacyclin production by endothelial cell growth factor: implications for chronic synovitis. (8321913)
1993
42
Magnetic resonance imaging of pigmented villonodular synovitis in subtalar joint. Report of a case. (1395260)
1992
43
Collagenase in synovitis of rheumatoid arthritis. (1411581)
1992
44
Mechanism of T-cell activation by mycobacterial antigens in inflammatory synovitis. (1901422)
1991
45
Imaging rounds #102. Pigmented villonodular synovitis. (2608308)
1989
46
Localized pigmented villonodular synovitis of the knee: diagnosis and arthroscopic resection. (3395414)
1988
47
The histopathology of Mycobacterium marinum synovitis. (3984939)
1985
48
Localized pigmented villonodular synovitis of the vertebral column. (6546511)
1984
49
Pigmented villonodular synovitis of the shoulder: radiologic-pathologic assessment. (6332500)
1984
50
Pigmented villonodular synovitis-like lesions in association with rare cases of rheumatoid arthritis, osteonecrosis, and advanced degenerative joint disease. Report of five cases. (6697577)
1984

Genetic Variations for Synovitis

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Expression for genes affiliated with Synovitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Synovitis

Search GEO for disease gene expression data for Synovitis.

Pathways for genes affiliated with Synovitis

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29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN
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Compounds for genes affiliated with Synovitis

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Synovitis according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1paraffin4411.4PTHLH, CSF1, CSF1R, PDGFRB, IBSP, BGLAP
2creatinine4411.4TNFRSF11B, PTHLH, ACP5, MMP9, MMP1, TNFSF11
3vegf4411.3SPP1, MMP9, MMP1, TNFSF11, CSF1, CSF1R
41,25 dihydroxy vitamin d34411.3TNFRSF11B, PTHLH, ACP5, TNFSF11, CSF1, CSF1R
5calcitriol44 59 11 2414.3BGLAP, CALCR, MMP1, PDGFRB, CSF1, TNFSF11
6cysteine4411.3MMP9, MMP1, IBSP, TNFRSF11B, TNFSF11, BGLAP
7vitamin d4411.3CALCR, SPP1, PTHLH, ACP5, TNFRSF11B, PDGFRB
8dexamethasone44 49 28 1114.3TNFSF11, MMP9, ACP5, BGLAP, TNFRSF11B, SPP1
9phosphatidylinositol4411.3CSF1, SPP1, TNFRSF11B, MMP9, PTHLH, CSF1R
10zoledronic acid4411.2BGLAP, IBSP, TNFRSF11B, MMP1, PTHLH, TNFSF11
11testosterone44 59 11 2414.2MMP9, SPP1, PTHLH, MMP1, PDGFRB, TNFRSF11B
12hydroxyproline44 11 2413.2MMP9, BGLAP, TNFRSF11B, ACP5, PTHLH, MMP1
13hydroxyapatite4411.2PTHLH, SPP1, ACP5, TNFRSF11B, TNFSF11, IBSP
14tgf beta14411.2CSF1, PDGFRB, PTHLH, SPP1, MMP9, MMP1
15tartrate4411.2TNFSF11, CSF1, CALCR, BGLAP, ACP5, PTHLH
16cyclosporin a44 28 5913.1TNFSF11, CALCR, BGLAP, TNFRSF11B, MMP9, MMP1
17titanium4411.1IBSP, BGLAP, SPP1, ACP5, TNFRSF11B, TNFSF11
18ns 39844 5912.1MMP9, TNFRSF11B, TNFSF11, CSF1, BGLAP, MMP1
1925-hydroxyvitamin d4411.1BGLAP, TNFSF11, PTHLH, SPP1, TNFRSF11B, ACP5
20tyrosine4411.1ACP5, MMP9, TNFRSF11B, TNFSF11, CSF1, SPP1
21phosphorus4411.1TNFSF11, PTHLH, BGLAP, SPP1, ACP5, TNFRSF11B
22clodronate44 49 1113.1TNFSF11, MMP1, ACP5, PTHLH, TNFRSF11B
23ascorbic acid44 2412.1MMP1, TNFRSF11B, SPP1, TNFSF11, CSF1, IBSP
24pamidronate44 49 1113.1MMP1, PTHLH, TNFSF11, TNFRSF11B, BGLAP
25pyridinoline4411.1ACP5, PTHLH, TNFRSF11B, IBSP, BGLAP
26heparin44 28 11 2414.1IBSP, SPP1, BGLAP, ACP5, TNFRSF11B, TNFSF11
27deoxypyridinoline4411.1TNFSF11, BGLAP, IBSP, TNFRSF11B, ACP5
28alendronate44 49 1113.0BGLAP, MMP1, TNFRSF11B, TNFSF11, PTHLH
29serine4411.0MMP1, TNFRSF11B, TNFSF11, CSF1, BGLAP, CSF1R
30pd 98,0594411.0CSF1R, CSF1, TNFSF11, MMP1, IBSP, SPP1
31procollagen4411.0TNFSF11, ACP5
32estradiol44 11 2413.0IBSP, CALCR, PTHLH, ACP5
33ibandronate44 1112.0TNFSF11, TNFRSF11B, IBSP, BGLAP
34infliximab44 49 1113.0SPP1, MMP1, TNFRSF11B, BGLAP, TNFSF11
35retinoic acid44 2412.0PDGFRB, SPP1, PTHLH, MMP9, MMP1, BGLAP
36matrigel4411.0PTHLH, PDGFRB, MMP1, IBSP
37pge24411.0MMP9
38genistein44 28 59 2 11 2415.9MMP9, SPP1, TNFRSF11B, TNFSF11, MMP1, PDGFRB
39vitamin k24410.9BGLAP, CSF1, TNFRSF11B, TNFSF11
40cycloheximide4410.9CSF1R, IBSP
41rantes4410.9CALCR, CSF1, ACP5
42celecoxib44 59 28 49 11 2415.9MMP1, CSF1, MMP9, TNFRSF11B, TNFSF11
43prostaglandin4410.9TNFRSF11B, CSF1, TNFSF11, MMP1
44geranylgeranyl pyrophosphate4410.9TNFSF11, TNFRSF11B, MMP9, MMP1
45azathioprine44 49 2 1113.8TNFSF11, TNFRSF11B, ACP5, PTHLH, BGLAP
46prednisolone44 28 1112.7BGLAP, TNFRSF11B, MMP1, PTHLH, CSF1
47etanercept44 49 1112.6TNFSF11, MMP1, CSF1, TNFRSF11B
48indomethacin44 59 28 1113.6SPP1, CSF1
49sb 20358044 5911.6SPP1, MMP9, MMP1, TNFRSF11B, TNFSF11, BGLAP
50troglitazone44 28 59 1113.4MMP1, SPP1, PTHLH, MMP9, CSF1

GO Terms for genes affiliated with Synovitis

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16Gene Ontology
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Cellular components related to Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.7SPP1, PVR, BGLAP, CSF1, TNFSF11, TNFRSF11B
2membrane-bounded vesicleGO:03198810.5SPP1, BGLAP
3extracellular regionGO:00557610.5BGLAP, IBSP, TNFSF11, TNFRSF11B, MMP1, MMP9

Biological processes related to Synovitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019810.9IBSP, TNFRSF11B, MMP1, MMP9, SPP1
2macrophage differentiationGO:03022510.8MMP9, CSF1, CSF1R
3osteoclast differentiationGO:03031610.8TNFSF11, CSF1, CSF1R
4skeletal system developmentGO:00150110.8BGLAP, TNFRSF11B, MMP9, PTHLH
5osteoclast proliferationGO:00215810.7TNFSF11, CSF1
6regulation of bone resorptionGO:04512410.6CSF1R, BGLAP
7ossificationGO:00150310.6IBSP, CSF1, TNFSF11
8positive regulation of bone resorptionGO:04578010.6SPP1, TNFSF11
9phosphatidylinositol metabolic processGO:04648810.5CSF1R, PDGFRB
10response to vitamin DGO:03328010.2SPP1, BGLAP

Molecular functions related to Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.6SPP1, TNFRSF11B, TNFSF11, CSF1

Products for genes affiliated with Synovitis

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Synovitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet