MCID: SYN007
MIFTS: 59

Synovitis malady

Summaries for Synovitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A connective tissue disease that results in inflammation located in synovial membrane that lines a synovial joint which causes pain and swelling.

MalaCards: Synovitis, also known as synovitis nos, is related to pigmented villonodular synovitis and arthritis. An important gene associated with Synovitis is MMP1 (matrix metallopeptidase 1 (interstitial collagenase)), and among its related pathways are Osteoclast differentiation and PI3K-Akt signaling pathway. The compounds paraffin and creatinine have been mentioned in the context of this disorder. Affiliated tissues include synovial membrane, bone and t cells, and related mouse phenotypes are immune system and skeleton.

Wikipedia:63 Synovitis is the medical term for inflammation of the synovial membrane. This membrane lines joints... more...

Aliases & Classifications for Synovitis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Related Diseases for Synovitis

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17GeneCards, 18GeneDecks
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Diseases in the Synovitis family:

Synovitis, Chronic

Diseases related to Synovitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 267)
idRelated DiseaseScoreTop Affiliating Genes
1pigmented villonodular synovitis31.7PDGFRB, LAPTM5, MOAP1, CSF1R, CSF1, ATP6V1B2
2arthritis31.3ACP5, MMP9, MMP1, TNFRSF11B, TNFSF11, CSF1
3rheumatoid arthritis31.2BGLAP, SPP1, IBSP, CSF1, TNFRSF11B, CD68
4hyperostosis30.9BGLAP
5osteoarthritis30.8PTHLH, BGLAP, SPP1, MMP9, MMP1, CD68
6giant cell tumor30.7TNFSF11, TNFRSF11B, CSF1, MMP9, BGLAP
7osteomyelitis30.5IBSP, TNFSF11, ACP5
8psoriatic arthritis30.4MMP1, TNFRSF11B, TNFSF11
9sarcoma30.2CSF1, CSF1R, PDGFRB
10arthropathy30.2MMP1, TNFRSF11B, TNFSF11
11osteonecrosis29.9BGLAP
12osteosarcoma29.7MMP9, SPP1, BGLAP, IBSP, PDGFRB, CSF1R
13melanoma29.7CSF1, PDGFRB, TNFSF11, TNFRSF11B, CD68, SPP1
14secondary syphilis29.7SPP1, PTHLH, ACP5, TNFSF11, TNFRSF11B, CSF1
15adenocarcinoma29.7SPP1, PTHLH, TNFSF11, IBSP, PDGFRB, MMP9
16leukemia29.7PDGFRB, CSF1R, CSF1, CALCR, ACP5
17diabetes mellitus29.7BGLAP, MMP9
18squamous cell carcinoma29.7PTHLH, CSF1R, MMP1, SPP1, MMP9, IBSP
19multicentric reticulohistiocytosis29.7CD68
20ankylosing spondylitis29.7BGLAP, TNFRSF11B, TNFSF11
21osteopetrosis autosomal dominant type 229.7TNFSF11, BGLAP
22villonodular synovitis11.1
23acne10.6
24sapho syndrome10.5
25polymyalgia rheumatica10.3
26tenosynovial giant cell tumor10.3
27hemarthrosis10.2
28transient arthritis10.2
29gonococcal synovitis10.1
30septic arthritis10.1
31pigmentation disease10.1
32reactive arthritis10.1
33malignant giant cell tumor10.1
34neuropathy10.1
35tuberculosis10.1
36carpal tunnel syndrome10.0
37lipoma10.0
38psoriasis10.0
39syphilis10.0
40talo-patello-scaphoid osteolysis, synovitis, and short fourth metacarpals10.0
41breast cancer10.0CSF1, IBSP, TNFRSF11B, MMP1, CALCR, TNFSF11
42myeloma10.0SPP1, IBSP, ACP5, TNFSF11, CALCR, PTHLH
43osteoporosis10.0BGLAP, CALCR, CSF1, SPP1, TNFSF11, PTHLH
44bone carcinoma10.0SPP1, PTHLH, MMP9, TNFRSF11B, TNFSF11, PDGFRB
45atherosclerosis10.0TNFRSF11B, PDGFRB, IBSP, CD68, MMP9, MMP1
46chronic kidney failure10.0SPP1, PTHLH, ACP5, TNFRSF11B, IBSP, BGLAP
47osteoporosis, postmenopausal10.0ACP5, BGLAP, IBSP, TNFSF11, TNFRSF11B, PTHLH
48hypercalcemia10.0TNFRSF11B, BGLAP, CALCR, CSF1, PTHLH, TNFSF11
49hyperparathyroidism10.0ACP5, TNFRSF11B, TNFSF11, BGLAP, PTHLH
50kidney cancer10.0PDGFRB, CSF1R, CSF1, MMP9, PTHLH, SPP1

Graphical network of the top 20 diseases related to Synovitis:



Diseases related to synovitis

Clinical Features for Synovitis

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Drugs & Therapeutics for Synovitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Synovitis

Drug clinical trials:

Search ClinicalTrials for Synovitis

Search NIH Clinical Center for Synovitis

Search CenterWatch for Synovitis

Genetic Tests for Synovitis

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Anatomical Context for Synovitis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Synovitis:

32
Bone, T cells, Bone marrow, Endothelial, B cells, Testes, Skin, Breast, Monocytes, Lung, Spinal cord, Prostate

FMA organs/tissues related to Synovitis:

14
Synovial membrane

Animal Models for Synovitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Synovitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.1TNFRSF11B, TNFSF11, CSF1, CSF1R, PDGFRB, PVR
2MP:000539011.0CALCR, IBSP, CSF1R, CSF1, TNFSF11, TNFRSF11B
3MP:000539710.9TNFRSF11B, TNFSF11, CSF1, CSF1R, PDGFRB, CALCR
4MP:000537610.8CSF1, CSF1R, PDGFRB, CALCR, PVR, TNFSF11
5MP:000538210.7CSF1R, PDGFRB, PTHLH, TNFSF11, TNFRSF11B, CSF1
6MP:000537110.7CSF1R, ACP5, CSF1
7MP:001077110.3CSF1R, TNFSF11, MMP9, SPP1

Publications for Synovitis

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50PubMed
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Articles related to Synovitis:

(show top 50)    (show all 1036)
idTitleAuthorsYear
1
Efficacy of Anti-TNF Agents as Adjunctive Therapy for Knee Synovitis Refractory to Disease-Modifying Antirheumatic Drugs in Patients with Peripheral Spondyloarthritis. (23840963)
2013
2
Magnetic resonance imaging and thallium-201 scintigraphy for the diagnosis of localized pigmented villonodular synovitis arising from the elbow: A case report and review of the literature. (23737864)
2013
3
Diffuse pigmented villonodular synovitis (diffuse-type giant cell tumour) of the foot and ankle. (23450025)
2013
4
Assessment of reactive synovitis in rotating-platform posterior-stabilized design: a 10-year prospective matched-pair MRI study. (23528558)
2013
5
Case of Buruli ulcer due to Mycobacterium ulcerans ssp. shinshuense with distal cutaneous involvement and synovitis. (22553785)
2012
6
Diffusion-weighted MRI of bone marrow oedema, soft tissue oedema and synovitis in paediatric patients: feasibility and initial experience. (22849717)
2012
7
Multi-drug-resistant Enterococcus spp. as a cause of non-responsive septic synovitis in three horses. (22506887)
2012
8
Detection of synovitis in the hands of patients with rheumatologic disorders: diagnostic performance of optical imaging in comparison with magnetic resonance imaging. (22421978)
2012
9
Use of amplified Mycobacterium tuberculosis direct test (Gen-probe Inc., San Diego, CA, USA) in the diagnosis of tubercular synovitis and early arthritis of knee joint. (23162145)
2012
10
Cell and cytokine imbalances in rheumatoid synovitis. (20961791)
2011
11
Effect of flunixin meglumine on the amelioration of lameness in dairy steers with amphotericin B-induced transient synovitis-arthritis. (22023120)
2011
12
Synovitis and osteitis are very frequent in rheumatoid arthritis clinical remission: results from an MRI study of 294 patients in clinical remission or low disease activity state. (21885514)
2011
13
Assessment of synovitis in erosive osteoarthritis of the hand using DCE-MRI and comparison with that in its major mimic, the psoriatic arthritis. (21419667)
2011
14
Limping in toddlers: pelvic abscess presenting with transient synovitis picture. (20947283)
2011
15
Radioactive synovectomy with Yttriuma8^a8^ citrate in haemophilic synovitis: Brazilian experience. (20731723)
2011
16
Excision of extensive midfoot pigmented villonodular synovitis with microvascular anastamosis of iliac crest bone graft using external fixation: a case report. (21926367)
2011
17
Comparison of clinical and ultrasonographic evaluations for peripheral synovitis in juvenile idiopathic arthritis. (21377713)
2011
18
Clinical synovitis in a particular joint is associated with progression of erosions and joint space narrowing in that same joint, but not in patients initially treated with infliximab. (20610442)
2010
19
Metallosis and Metal-Induced Synovitis Following Total Knee Arthroplasty: Review of Radiographic and CT Findings. (22470753)
2010
20
Arthroscopic treatment of pigmented villonodular synovitis involving bilateral shoulders. (20806759)
2010
21
Serum cortisol concentration and force plate analysis in the assessment of pain associated with sodium urate-induced acute synovitis in dogs. (20673094)
2010
22
Pigmented villonodular synovitis with bicortical erosions in the thumb. (20118134)
2010
23
Pigmented villonodular synovitis: an overdiagnosed entity. (19817903)
2009
24
Pigmented villonodular synovitis of the elbow with a fenestrated fossa: a case report. (19398811)
2009
25
Pigmented villonodular synovitis of thoracic facet joint presenting as rapidly progressive paraplegia. (19955996)
2009
26
Comparative histopathological analysis between tenosynovitis and joint synovitis in rheumatoid arthritis. (18462359)
2008
27
B lymphocyte autoimmunity in rheumatoid synovitis is independent of ectopic lymphoid neogenesis. (18566445)
2008
28
Ulnar neuropathy type-III at the hand due to chronic non-specific synovitis. (17428720)
2007
29
Pigmented villonodular synovitis of the calcaneocuboid joint in an 11-year-old child with subtalar coalition. (17475149)
2007
30
Clinical characteristics of polymyalgia rheumatica in Japanese patients: evidence of synovitis and extracapsular inflammatory changes by fat suppression magnetic resonance imaging. (17929127)
2007
31
Mycobacterium chelonae synovitis. (17072142)
2006
32
Tumour necrosis factor alpha blockade in treatment resistant pigmented villonodular synovitis. (15297283)
2005
33
Recurrent hemarthrosis of the knee mimicking pigmented villonodular synovitis. (15658150)
2005
34
Subcutaneous pigmented villonodular synovitis caused by portal contamination during knee arthroscopy and open synovectomy. (15067291)
2004
35
Pigmented villonodular synovitis of the temporomandibular joint: an extensive case with skull-base involvement. (15124172)
2004
36
Association of CD163+ macrophages and local production of soluble CD163 with decreased lymphocyte activation in spondylarthropathy synovitis. (15146432)
2004
37
Ultrasonographic evaluation of knee joint synovitis in two patients with palindromic rheumatism. (24387063)
2002
38
Extra-articular pigmented villonodular synovitis of the temporomandibular joint: case report and review of the literature. (11202319)
2000
39
Villonodular synovitis of the knee with extensive extraarticular involvement. Report of a case. (10036705)
1999
40
Pigmented villonodular synovitis of the shoulder: review and case report. (10462217)
1999
41
Pigmented villonodular synovitis of the wrist in childhood. (9241482)
1997
42
Tissue cytokine patterns distinguish variants of rheumatoid synovitis. (9358757)
1997
43
Outcome following radiation treatment for high-risk pigmented villonodular synovitis. (7790264)
1995
44
Pigmented villonodular synovitis of the hip: review of radiographic features in 58 patients. (7709244)
1995
45
Pigmented villonodular synovitis. Monoclonality and metastasis--a case for neoplastic origin? (7863772)
1995
46
Pigmented villonodular synovitis. Pedal manifestations. (7807386)
1994
47
Pigmented villonodular synovitis of the knee demonstrated on bone scan. Correlation with US, CT, and MRI. (1424384)
1992
48
T cell receptor delta diversity of freshly isolated T lymphocytes in rheumatoid synovitis. (1825059)
1991
49
Pigmented villonodular synovitis of the extensor tendon sheaths in a child. (3171302)
1988
50
Experimental hemarthrosis in dogs: progressive synovitis monitored with technetium-99m pyrophosphate joint imaging. (2842240)
1988

Genetic Variations for Synovitis

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Expression for genes affiliated with Synovitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Synovitis

Search GEO for disease gene expression data for Synovitis.

Pathways for genes affiliated with Synovitis

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29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN
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Compounds for genes affiliated with Synovitis

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Synovitis according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1paraffin4411.4PTHLH, CSF1, CSF1R, PDGFRB, IBSP, BGLAP
2creatinine4411.4TNFRSF11B, PTHLH, ACP5, MMP9, MMP1, TNFSF11
3vegf4411.3SPP1, MMP9, MMP1, TNFSF11, CSF1, CSF1R
41,25 dihydroxy vitamin d34411.3TNFRSF11B, PTHLH, ACP5, TNFSF11, CSF1, CSF1R
5calcitriol44 59 11 2414.3BGLAP, CALCR, MMP1, PDGFRB, CSF1, TNFSF11
6cysteine4411.3MMP9, MMP1, IBSP, TNFRSF11B, TNFSF11, BGLAP
7vitamin d4411.3CALCR, SPP1, PTHLH, ACP5, TNFRSF11B, PDGFRB
8dexamethasone44 49 28 1114.3TNFSF11, MMP9, ACP5, BGLAP, TNFRSF11B, SPP1
9phosphatidylinositol4411.3CSF1, SPP1, TNFRSF11B, MMP9, PTHLH, CSF1R
10zoledronic acid4411.2BGLAP, IBSP, TNFRSF11B, MMP1, PTHLH, TNFSF11
11testosterone44 59 11 2414.2MMP9, SPP1, PTHLH, MMP1, PDGFRB, TNFRSF11B
12hydroxyproline44 11 2413.2MMP9, BGLAP, TNFRSF11B, ACP5, PTHLH, MMP1
13hydroxyapatite4411.2PTHLH, SPP1, ACP5, TNFRSF11B, TNFSF11, IBSP
14tgf beta14411.2CSF1, PDGFRB, PTHLH, SPP1, MMP9, MMP1
15tartrate4411.2TNFSF11, CSF1, CALCR, BGLAP, ACP5, PTHLH
16cyclosporin a44 28 5913.1TNFSF11, CALCR, BGLAP, TNFRSF11B, MMP9, MMP1
17titanium4411.1IBSP, BGLAP, SPP1, ACP5, TNFRSF11B, TNFSF11
18ns 39844 5912.1MMP9, TNFRSF11B, TNFSF11, CSF1, BGLAP, MMP1
1925-hydroxyvitamin d4411.1BGLAP, TNFSF11, PTHLH, SPP1, TNFRSF11B, ACP5
20tyrosine4411.1ACP5, MMP9, TNFRSF11B, TNFSF11, CSF1, SPP1
21phosphorus4411.1TNFSF11, PTHLH, BGLAP, SPP1, ACP5, TNFRSF11B
22clodronate44 49 1113.1TNFSF11, MMP1, ACP5, PTHLH, TNFRSF11B
23ascorbic acid44 2412.1MMP1, TNFRSF11B, SPP1, TNFSF11, CSF1, IBSP
24pamidronate44 49 1113.1MMP1, PTHLH, TNFSF11, TNFRSF11B, BGLAP
25pyridinoline4411.1ACP5, PTHLH, TNFRSF11B, IBSP, BGLAP
26heparin44 28 11 2414.1IBSP, SPP1, BGLAP, ACP5, TNFRSF11B, TNFSF11
27deoxypyridinoline4411.1TNFSF11, BGLAP, IBSP, TNFRSF11B, ACP5
28alendronate44 49 1113.0BGLAP, MMP1, TNFRSF11B, TNFSF11, PTHLH
29serine4411.0MMP1, TNFRSF11B, TNFSF11, CSF1, BGLAP, CSF1R
30pd 98,0594411.0CSF1R, CSF1, TNFSF11, MMP1, IBSP, SPP1
31procollagen4411.0TNFSF11, ACP5
32estradiol44 11 2413.0IBSP, CALCR, PTHLH, ACP5
33ibandronate44 1112.0TNFSF11, TNFRSF11B, IBSP, BGLAP
34infliximab44 49 1113.0SPP1, MMP1, TNFRSF11B, BGLAP, TNFSF11
35retinoic acid44 2412.0PDGFRB, SPP1, PTHLH, MMP9, MMP1, BGLAP
36matrigel4411.0PTHLH, PDGFRB, MMP1, IBSP
37pge24411.0MMP9
38genistein44 28 59 2 11 2415.9MMP9, SPP1, TNFRSF11B, TNFSF11, MMP1, PDGFRB
39vitamin k24410.9BGLAP, CSF1, TNFRSF11B, TNFSF11
40cycloheximide4410.9CSF1R, IBSP
41rantes4410.9CALCR, CSF1, ACP5
42celecoxib44 59 28 49 11 2415.9MMP1, CSF1, MMP9, TNFRSF11B, TNFSF11
43prostaglandin4410.9TNFRSF11B, CSF1, TNFSF11, MMP1
44geranylgeranyl pyrophosphate4410.9TNFSF11, TNFRSF11B, MMP9, MMP1
45azathioprine44 49 2 1113.8TNFSF11, TNFRSF11B, ACP5, PTHLH, BGLAP
46prednisolone44 28 1112.7BGLAP, TNFRSF11B, MMP1, PTHLH, CSF1
47etanercept44 49 1112.6TNFSF11, MMP1, CSF1, TNFRSF11B
48indomethacin44 59 28 1113.6SPP1, CSF1
49sb 20358044 5911.6SPP1, MMP9, MMP1, TNFRSF11B, TNFSF11, BGLAP
50troglitazone44 28 59 1113.4MMP1, SPP1, PTHLH, MMP9, CSF1

GO Terms for genes affiliated with Synovitis

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16Gene Ontology
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Cellular components related to Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.7PTHLH, PVR, BGLAP, CSF1, TNFSF11, TNFRSF11B
2membrane-bounded vesicleGO:03198810.5SPP1, BGLAP
3extracellular regionGO:00557610.5SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B, MMP1

Biological processes related to Synovitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019810.9IBSP, TNFRSF11B, MMP1, MMP9, SPP1
2macrophage differentiationGO:03022510.8MMP9, CSF1, CSF1R
3osteoclast differentiationGO:03031610.8TNFSF11, CSF1, CSF1R
4skeletal system developmentGO:00150110.8BGLAP, TNFRSF11B, MMP9, PTHLH
5osteoclast proliferationGO:00215810.7TNFSF11, CSF1
6regulation of bone resorptionGO:04512410.6CSF1R, BGLAP
7ossificationGO:00150310.6IBSP, CSF1, TNFSF11
8positive regulation of bone resorptionGO:04578010.6SPP1, TNFSF11
9phosphatidylinositol metabolic processGO:04648810.5CSF1R, PDGFRB
10response to vitamin DGO:03328010.2SPP1, BGLAP

Molecular functions related to Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.6SPP1, TNFRSF11B, TNFSF11, CSF1

Products for genes affiliated with Synovitis

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Synovitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet