MCID: SYN007
MIFTS: 59

Synovitis malady

Rare diseases category

Summaries for Synovitis

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Disease Ontology:9 A connective tissue disease that results in inflammation located in synovial membrane that lines a synovial joint which causes pain and swelling.

MalaCards based summary: Synovitis, also known as synovitis nos, is related to pigmented villonodular synovitis and giant cell tumor. An important gene associated with Synovitis is MMP1 (matrix metallopeptidase 1 (interstitial collagenase)), and among its related pathways are Macrophage Differentiation and Growth Inhibition by METS and Interleukin-11 Signaling Pathway. The compounds pyridinoline and ibandronate have been mentioned in the context of this disorder. Affiliated tissues include synovial membrane, bone and t cells, and related mouse phenotypes are endocrine/exocrine gland and craniofacial.

Wikipedia:64 Synovitis is the medical term for inflammation of the synovial membrane. This membrane lines joints... more...

Aliases & Classifications for Synovitis

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Synovitis, Aliases & Descriptions:

Name: Synovitis 9 42 11 44 61
 
Synovitis Nos 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:2703
MeSH34 D013585
NCIt39 C50766
ICD1026 M65.9

Related Diseases for Synovitis

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Diseases in the Synovitis family:

Synovitis, Chronic

Diseases related to Synovitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 260)
idRelated DiseaseScoreTop Affiliating Genes
1pigmented villonodular synovitis32.0CSF1R, CSF1, PDGFRB
2giant cell tumor31.1TNFSF11, CSF1R, CSF1
3osteomyelitis31.0IBSP, TNFSF11, ACP5
4psoriatic arthritis30.9TNFSF11, TNFRSF11B, MMP1
5arthropathy30.7MMP1, TNFRSF11B, TNFSF11
6osteonecrosis30.6BGLAP
7arthritis30.3BGLAP, TNFSF11, TNFRSF11B, MMP9, MMP1, ACP5
8ankylosing spondylitis30.3BGLAP, TNFSF11, TNFRSF11B
9sarcoma30.2CSF1R, CSF1, PDGFRB
10osteopetrosis autosomal dominant type 230.2BGLAP, TNFSF11
11rheumatic disease30.0BGLAP, TNFSF11, TNFRSF11B
12myelodysplastic syndromes29.9PDGFRB, CSF1, CSF1R
13rheumatoid arthritis29.8SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B, MMP9
14osteoarthritis28.9CSF1, CSF1R, ACP5, MMP1, MMP9, PTHLH
15secondary syphilis28.7CSF1, ACP5, PTHLH, TNFRSF11B, TNFSF11, IBSP
16adenocarcinoma28.5SPP1, IBSP, TNFSF11, PTHLH, MMP9, CSF1R
17melanoma28.3SPP1, IBSP, TNFSF11, TNFRSF11B, MMP9, MMP1
18osteosarcoma27.4PDGFRB, CSF1, CSF1R, ACP5, MMP1, MMP9
19villonodular synovitis11.2
20acne10.7
21hyperostosis10.7
22sapho syndrome10.6
23cherubism10.5TNFSF11
24periapical granuloma10.5TNFSF11
25camurati-engelmann disease10.4BGLAP
26paget disease, juvenile10.4TNFSF11, TNFRSF11B
27polyostotic osteolytic dysplasia, hereditary expansile10.4TNFSF11, TNFRSF11B
28osteosclerosis10.4TNFSF11, TNFRSF11B
29fibromatosis10.4PDGFRB
30polymyalgia rheumatica10.3
31beta thalassemia10.3TNFSF11, TNFRSF11B
32acute myelomonocytic leukemia10.3CSF1, CSF1R
33tenosynovial giant cell tumor10.3
34malignant histiocytosis10.3CSF1R, CSF1
35gingivitis10.3MMP1, TNFRSF11B, TNFSF11
36hemarthrosis10.3
37endometrial stromal sarcoma10.3CSF1, PDGFRB
38ameloblastoma10.3IBSP, TNFSF11, TNFRSF11B
39fibrous dysplasia10.2IBSP, BGLAP
40septic arthritis10.2
41endotheliitis10.2
42pseudohypoparathyroidism type 1b10.2PTHLH, BGLAP
43dentin dysplasia10.2SPP1, IBSP
44pseudohypoparathyroidism10.2BGLAP, PTHLH
45nephrolithiasis10.2IBSP, SPP1
46hyperphosphatemia10.2TNFRSF11B, SPP1
47dentinogenesis imperfecta10.2SPP1, IBSP
48gonococcal synovitis10.2
49lung cancer10.2MMP9
50periodontal disease10.2MMP1, TNFSF11

Graphical network of the top 20 diseases related to Synovitis:



Diseases related to synovitis

Symptoms for Synovitis

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Drugs & Therapeutics for Synovitis

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Drug clinical trials:

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Genetic Tests for Synovitis

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Anatomical Context for Synovitis

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MalaCards organs/tissues related to Synovitis:

32
Bone, T cells, Bone marrow, Endothelial, Neutrophil, Skin, Testes, B cells, Spinal cord, Lung, Breast, Prostate, Monocytes

FMA organs/tissues related to Synovitis:

15
Synovial membrane

Animal Models for Synovitis or affiliated genes

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Publications for Synovitis

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Articles related to Synovitis:

(show top 50)    (show all 1064)
idTitleAuthorsYear
1
Transtrochanteric rotational osteotomy combined with intra-articular procedures for pigmented villonodular synovitis of the hip. (24687213)
2014
2
Unusual cases of pigmented villonodular synovitis after arthroplasty. (24955198)
2014
3
Patients with rheumatoid arthritis in clinical remission and ultrasound-defined active synovitis exhibit higher disease activity and increased serum levels of angiogenic biomarkers. (24398122)
2014
4
Comparison of arthroscopic, radioactive and combined synovectomy in the treatment of chronic non-specific knee synovitis. (25196268)
2014
5
In patients with early rheumatoid arthritis, the new ACR/EULAR definition of remission identifies patients with persistent absence of functional disability and suppression of ultrasonographic synovitis. (23060009)
2013
6
Synovitis and bone inflammation in early rheumatoid arthritis: high-resolution multi-pinhole SPECT versus MRI. (23255070)
2013
7
Low-dose external beam radiotherapy as a postoperative treatment for patients with diffuse pigmented villonodular synovitis of the knee: 4 recurrences in 23 patients followed for mean 9 years. (22489888)
2012
8
Hip joint pigmented villonodular synovitis in a young girl: a case report. (22433958)
2012
9
Pigmented villonodular synovitis of the ankle presenting as a persisting ankle effusion. (22764668)
2012
10
Chondroblastoma of the femoral neck as a cause of hip synovitis. (21685802)
2012
11
Case 181: synovitis acne pustulosis hyperostosis osteitis (SAPHO) syndrome. (22517965)
2012
12
The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis). (22733940)
2012
13
One step open synovectomy without adjuvant therapy for diffuse pigmented villonodular synovitis of the knee in a soccer player. (23738243)
2011
14
Utility of ultrasound joint counts in the prediction of rheumatoid arthritis in patients with very early synovitis. (21115552)
2011
15
Correlation between synovitis detected on enhanced-magnetic resonance imaging and a histological analysis with a patient-oriented outcome measure for Japanese patients with end-stage knee osteoarthritis receiving joint replacement surgery. (20567866)
2010
16
Clinical synovitis in a particular joint is associated with progression of erosions and joint space narrowing in that same joint, but not in patients initially treated with infliximab. (20610442)
2010
17
MRI of macrophages in infectious knee synovitis. (20489072)
2010
18
Metallosis and Metal-Induced Synovitis Following Total Knee Arthroplasty: Review of Radiographic and CT Findings. (22470753)
2010
19
Quantification of synovitis in rheumatoid arthritis: do we really need quantitative measurement of contrast-enhanced ultrasound? (19410408)
2009
20
Semiquantitative assessment of synovitis in osteoarthritis on non contrast-enhanced MRI. (19070515)
2009
21
Tuberculous synovitis of the hip joint diagnosed by FDG PET-CT. (19542947)
2009
22
Lyme arthritis presenting as transient synovitis of the hip. (18519920)
2008
23
Synovial lymphoid neogenetic factors in BehAset's synovitis: do they play a role in self-limiting and subacute course of arthritis? (17949547)
2007
24
Radial and ulnar neuropathy due to pigmented villonodular synovitis of the elbow. (17126239)
2006
25
Pigmented villonodular synovitis. (16311109)
2006
26
Role of osteopontin in amplification and perpetuation of rheumatoid synovitis. (15761492)
2005
27
Involvement of matrix metalloproteinases and their inhibitors in peripheral synovitis and down-regulation by tumor necrosis factor alpha blockade in spondylarthropathy. (15457463)
2004
28
Pigmented villonodular synovitis: a disease in evolution. (15290750)
2004
29
New strategies to control inflammatory synovitis: interleukin 15 and beyond. (14532150)
2003
30
Chronic synovitis and HLA B27 in patients with severe haemophilia. (12648975)
2003
31
c-myc proto-oncogene expression in hemophilic synovitis: in vitro studies of the effects of iron and ceramide. (12130502)
2002
32
Tuberculosis of the hip as the presenting sign of HIV and simulating pigmented villonodular synovitis. (12107577)
2002
33
Villonodular synovitis of the temporomandibular joint: case report. (11732040)
2001
34
Intraarticular osteoid osteoma associated with synovitis: a possible role of cyclooxygenase-2 expression by osteoblasts in the nidus. (11048802)
2000
35
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
36
Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome presenting as a primary calvarial lesion. Case report and review of the literature. (11014551)
2000
37
Lipoma induced by pigmented villonodular synovitis of the ankle. (10359296)
1999
38
An unusual case of pigmented villonodular synovitis of the spine: benign aggressive and/or malignant? (10371292)
1999
39
Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction. (9807705)
1998
40
Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome: a brief review of a rare condition. (9588288)
1998
41
Articular pigmented villonodular synovitis of the MP joint of the hand. (8543887)
1995
42
Diagnostic features of diffuse pigmented villonodular synovitis of the knee. (8118978)
1994
43
Pigmented villonodular synovitis of the knee demonstrated on bone scan. Correlation with US, CT, and MRI. (1424384)
1992
44
Expression of decay-accelerating factor is reduced on hyperplastic synovial lining cells in rheumatoid synovitis. (1706235)
1991
45
Low levels of interleukin-4 and high levels of transforming growth factor beta in rheumatoid synovitis. (2390123)
1990
46
Role of cytokines in inflammatory synovitis. The coordinate regulation of intercellular adhesion molecule 1 and HLA class I and class II antigens in rheumatoid synovial fibroblasts. (1701992)
1990
47
Case report 578: Pigmented villonodular synovitis of the shoulder. (2321043)
1990
48
Pigmented villonodular synovitis of the hip--association with osteochondromatosis. (3440329)
1987
49
Pigmented villonodular synovitis of the temporomandibular joint: a case report. (10994414)
1982
50
Arthrographic findings in Legg-CalvAc-Perthes disease and transient synovitis of the hip. (670266)
1978

Variations for Synovitis

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Expression for genes affiliated with Synovitis

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Expression patterns in normal tissues for genes affiliated with Synovitis

Search GEO for disease gene expression data for Synovitis.

Pathways for genes affiliated with Synovitis

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Pathways related to Synovitis according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7CSF1R, CSF1
29.6IBSP, BGLAP
3
Show member pathways
RANKL/RANK Signaling Pathway37
Apoptosis and survival APRIL and BAFF signaling59
9.5ACP5, TNFRSF11B, TNFSF11
49.4MMP9, MMP1
59.4MMP9, MMP1
69.2PDGFRB, CSF1, CSF1R
79.2CSF1R, CSF1, PDGFRB
89.2TNFSF11, MMP1, ACP5, CSF1
99.1CSF1, CSF1R, SPP1
10
Show member pathways
Apoptosis and survival TNFR1 signaling pathway59
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
9.1MMP9, TNFRSF11B, TNFSF11
119.0MMP9, SPP1
129.0SPP1, MMP9
139.0IBSP, TNFSF11, TNFRSF11B, PDGFRB
14
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
9.0PDGFRB, IBSP, SPP1
15
Show member pathways
8.9TNFSF11, CSF1R, CSF1, PDGFRB
16
Show member pathways
8.9TNFSF11, CSF1R, CSF1, PDGFRB
178.9ACP5, TNFRSF11B, TNFSF11, SPP1
188.9MMP1, MMP9, BGLAP
19
Show member pathways
Signaling Pathways in Glioblastoma37
8.9MMP9, MMP1, PDGFRB
208.8TNFSF11, TNFRSF11B, ACP5, CSF1R, CSF1
218.7TNFRSF11B, TNFSF11, BGLAP, SPP1
22
Show member pathways
8.6TNFSF11, TNFRSF11B, CSF1R, CSF1, PDGFRB
238.6MMP9, PTHLH, SPP1
248.5SPP1, BGLAP, MMP9
258.5MMP9, MMP1, CSF1R, PDGFRB
26
Show member pathways
8.5MMP9, MMP1, CSF1R, PDGFRB
27
Show member pathways
8.4SPP1, IBSP, MMP9, MMP1
28
Show member pathways
8.3PDGFRB, CSF1, CSF1R, TNFSF11, SPP1
298.3SPP1, IBSP, CSF1R, CSF1, PDGFRB
308.2PTHLH, TNFSF11, IBSP, BGLAP, SPP1

Compounds for genes affiliated with Synovitis

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Compounds related to Synovitis according to GeneCards/GeneDecks:

(show top 50)    (show all 183)
idCompoundScoreTop Affiliating Genes
1pyridinoline4410.6TNFRSF11B
2ibandronate44 1210.3IBSP, TNFRSF11B, TNFSF11, BGLAP
3vitamin k2449.3BGLAP, TNFRSF11B, CSF1, TNFSF11
4pamidronate44 50 1211.0BGLAP, TNFSF11, TNFRSF11B, PTHLH, MMP1
5deoxypyridinoline449.0TNFRSF11B, ACP5, BGLAP, IBSP, TNFSF11
6alendronate44 50 1211.0BGLAP, TNFSF11, TNFRSF11B, MMP1, PTHLH
7tartrate448.9TNFSF11, CSF1, ACP5, PTHLH, BGLAP
8infliximab44 50 1210.7TNFSF11, MMP1, TNFRSF11B, BGLAP, SPP1
9clodronate44 50 1210.7BGLAP, ACP5, MMP1, PTHLH, TNFRSF11B, TNFSF11
10celecoxib44 60 29 50 25 1213.6TNFSF11, CSF1, MMP1, MMP9, TNFRSF11B
11geranylgeranyl pyrophosphate448.5TNFRSF11B, MMP1, TNFSF11, MMP9
12titanium448.4TNFSF11, ACP5, IBSP, BGLAP, SPP1, TNFRSF11B
13ns 39844 609.4MMP1, TNFSF11, BGLAP, TNFRSF11B, MMP9, CSF1
1425-hydroxyvitamin d448.3PTHLH, TNFRSF11B, TNFSF11, SPP1, BGLAP, ACP5
15phosphorus448.3SPP1, BGLAP, TNFSF11, TNFRSF11B, PTHLH, ACP5
16indomethacin44 29 60 1211.3TNFRSF11B, CSF1, MMP1, PTHLH, TNFSF11, SPP1
17prostaglandin448.3CSF1, TNFSF11, MMP1, TNFRSF11B, MMP9, PTHLH
18rantes448.2TNFRSF11B, CSF1, ACP5, MMP9, TNFSF11, MMP1
19estradiol44 25 1210.2TNFRSF11B, TNFSF11, MMP1, PTHLH, ACP5, IBSP
20ascorbic acid44 259.2CSF1, SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B
21hydroxyapatite448.0BGLAP, IBSP, TNFSF11, TNFRSF11B, PTHLH, ACP5
22zoledronic acid447.9IBSP, TNFSF11, TNFRSF11B, PTHLH, MMP9, MMP1
23hydroxyproline44 25 129.8BGLAP, IBSP, TNFRSF11B, PTHLH, MMP9, MMP1
24pd 98,059447.7SPP1, IBSP, TNFSF11, MMP9, MMP1, CSF1R
25sb 20358044 608.7MMP9, BGLAP, SPP1, MMP1, TNFSF11, TNFRSF11B
26genistein44 29 60 3 25 1212.6TNFSF11, SPP1, PDGFRB, CSF1, TNFRSF11B, MMP9
27heparin44 29 25 1210.6SPP1, IBSP, CSF1, ACP5, PTHLH, TNFRSF11B
28tgf beta1447.6MMP1, TNFRSF11B, PTHLH, SPP1, PDGFRB, CSF1
29h2o2447.5PDGFRB, BGLAP, CSF1, SPP1, ACP5, TNFSF11
30cyclosporin a44 29 609.5MMP1, BGLAP, ACP5, TNFRSF11B, SPP1, TNFSF11
31progesterone44 29 60 25 1211.5SPP1, CSF1R, MMP1, CSF1, PDGFRB, TNFRSF11B
32matrigel447.5IBSP, PDGFRB, PTHLH, SPP1, MMP9, MMP1
33procollagen447.4SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B, MMP9
341,25 dihydroxy vitamin d3447.3PTHLH, CSF1R, CSF1, ACP5, TNFRSF11B, SPP1
35calcitriol44 60 25 1210.2TNFSF11, BGLAP, SPP1, TNFRSF11B, PTHLH, MMP1
36vitamin d447.1SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B, PTHLH
37cycloheximide447.0IBSP, SPP1, CSF1, CSF1R, MMP1, MMP9
38phosphatidylinositol446.8IBSP, PTHLH, TNFRSF11B, TNFSF11, MMP9, CSF1R
39testosterone44 60 25 129.7PDGFRB, MMP1, PTHLH, TNFRSF11B, TNFSF11, BGLAP
40creatinine446.6MMP1, ACP5, CSF1, SPP1, BGLAP, IBSP
41retinoic acid44 257.6SPP1, BGLAP, TNFRSF11B, PTHLH, MMP9, MMP1
42tyrosine446.3PDGFRB, CSF1, CSF1R, ACP5, MMP9, PTHLH
43dexamethasone44 50 29 129.2CSF1, CSF1R, ACP5, MMP1, MMP9, PTHLH
44pge2446.2ACP5, SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B
45calcium44 50 25 129.1PTHLH, SPP1, BGLAP, IBSP, PDGFRB, ACP5
46cysteine446.1PDGFRB, CSF1, CSF1R, ACP5, MMP1, MMP9
47vegf446.0BGLAP, SPP1, IBSP, TNFSF11, TNFRSF11B, PDGFRB
48serine446.0PTHLH, SPP1, BGLAP, TNFSF11, CSF1, CSF1R
49paraffin446.0IBSP, BGLAP, SPP1, TNFSF11, PTHLH, PDGFRB
50estrogen445.6BGLAP, SPP1, TNFSF11, IBSP, PDGFRB, CSF1

GO Terms for genes affiliated with Synovitis

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Cellular components related to Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.1MMP1, MMP9, TNFRSF11B
2membrane-bounded vesicleGO:0319889.0BGLAP, SPP1
3extracellular spaceGO:0056157.0SPP1, BGLAP, TNFSF11, TNFRSF11B, PTHLH, MMP9
4extracellular regionGO:0055766.9MMP1, SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B

Biological processes related to Synovitis according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1osteoclast proliferationGO:00215810.2CSF1, TNFSF11
2positive regulation of osteoclast differentiationGO:04567210.0CSF1, TNFSF11
3bone resorptionGO:04545310.0TNFSF11, ACP5
4regulation of bone resorptionGO:0451249.8BGLAP, CSF1R
5phosphatidylinositol metabolic processGO:0464889.8PDGFRB, CSF1R
6positive regulation of bone resorptionGO:0457809.8TNFSF11, SPP1
7osteoclast differentiationGO:0303169.8CSF1, CSF1R, TNFSF11
8osteoblast developmentGO:0020769.7PTHLH, BGLAP
9odontogenesisGO:0424769.7CSF1, BGLAP
10positive regulation of MAP kinase activityGO:0434069.7PDGFRB, TNFSF11
11biomineral tissue developmentGO:0312149.6IBSP, SPP1
12response to vitamin DGO:0332809.6SPP1, BGLAP
13cellular response to growth factor stimulusGO:0713639.5BGLAP, IBSP
14positive regulation of cell migrationGO:0303359.5PDGFRB, CSF1, CSF1R
15macrophage differentiationGO:0302259.3CSF1, CSF1R, MMP9
16extracellular matrix disassemblyGO:0226179.0MMP1, MMP9, SPP1
17ossificationGO:0015039.0CSF1, MMP9, TNFSF11, IBSP
18positive regulation of cell proliferationGO:0082849.0PTHLH, CSF1R, CSF1, PDGFRB
19embryo implantationGO:0075669.0MMP9, SPP1
20inflammatory responseGO:0069548.8CSF1, CSF1R, SPP1
21skeletal system developmentGO:0015018.7BGLAP, TNFRSF11B, PTHLH, MMP9
22extracellular matrix organizationGO:0301988.5SPP1, IBSP, TNFRSF11B, MMP9, MMP1

Molecular functions related to Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.9CSF1, TNFRSF11B, TNFSF11, SPP1

Products for genes affiliated with Synovitis

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Sources for Synovitis

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4CDC
14ExPASy
15FMA
23GTR
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25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
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62UMLS via Orphanet