Aliases & Classifications for Synovitis

Summaries for Synovitis

Disease Ontology : 12 A connective tissue disease that results_in inflammation located in synovial membrane that lines a synovial joint which causes pain and swelling.

MalaCards based summary : Synovitis is related to camptodactyly-arthropathy-coxa vara-pericarditis syndrome and tuberculosis, and has symptoms including arthralgia, metatarsalgia and myalgia. An important gene associated with Synovitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Bevacizumab and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and bone marrow, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 71 Synovitis is the medical term for inflammation of the synovial membrane. This membrane lines joints that... more...

Related Diseases for Synovitis

Diseases related to Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 379)
id Related Disease Score Top Affiliating Genes
1 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 31.2 CRP CXCL8 ICAM1 IL1B IL6 TNF
2 tuberculosis 30.0 IL1B IL6 TNF
3 neuropathy 29.6 CRP CXCL8 IL1B IL6 TNF
4 peroneal neuropathy 29.3 CRP IL1B IL6 TNF
5 rheumatoid arthritis 28.8 COMP CRP CXCL8 ICAM1 IL18 IL1B
6 osteonecrosis 28.1 COMP CRP CXCL8 IL1B IL6 MMP1
7 pigmented villonodular synovitis 12.4
8 villonodular synovitis 12.3
9 gonococcal synovitis 11.9
10 talo-patello-scaphoid osteolysis, synovitis, and short fourth metacarpals 11.8
11 sapho syndrome 11.8
12 noonan syndrome 1 11.4
13 intermittent hydrarthrosis 11.1
14 legg-calve-perthes disease 11.1
15 eosinophilic fasciitis 11.1
16 blau syndrome 10.9
17 noonan syndrome 4 10.8
18 sarcoidosis, early-onset 10.7
19 arthritis 10.6
20 intussusception 10.4 IL1B TNF
21 symmastia 10.4 MMP1 MMP3
22 acne 10.3
23 hyperostosis 10.3
24 idiopathic corneal edema 10.3 IL1B MMP1 MMP3
25 tau syndrome 10.3 IL18 IL1B TNF
26 amyotrophic lateral sclerosis type 14 10.3 CXCL8 IL1B TNF
27 parkinson disease 11 10.3 CXCL8 IL1B TNF
28 osteoarthritis 10.3
29 ovarian cystic teratoma 10.3 CXCL8 IL1B TNF
30 nasal cavity inverting papilloma 10.3 CXCL8 MMP13 TNFSF11
31 bone resorption disease 10.2 IL1B MMP13 MMP3
32 spastic hemiplegia 10.2 ICAM1 MMP1 TNFSF11
33 glucose intolerance 10.2 CXCL8 IL18 TNF
34 cataract 10.2 CRP IL1B TNF
35 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.2 IL6 TNF
36 phka2-related phosphorylase kinase deficiency 10.2 TNFRSF11B TNFSF11
37 pasteurellosis 10.2 IL6 MMP1 MMP3
38 lymphedema 10.2 ICAM1 IL1B VCAM1
39 anal paget's disease 10.2 IL1B IL6 TNF
40 bipolar i disorder 10.2 IL1B IL6 TNF
41 oculomotor nerve paralysis 10.2 CXCL8 IL1B IL6
42 cerebrum cancer 10.2 CRP IL1B VCAM1
43 pyloric stenosis, infantile hypertrophic, 2 10.2 CRP IL1B TNF
44 common peroneal nerve lesion 10.2 CXCL8 IL1B IL6
45 tinea capitis 10.2 IL1B IL6 TNF
46 measles 10.2 IL1B IL6 TNF
47 appendiceal l-cell glucagon-like peptide producing tumor 10.2 CRP CXCL8 MMP3
48 hidradenitis 10.2 CRP CXCL8 IL1B
49 perrault syndrome 10.2 ICAM1 MMP1 VCAM1
50 hypoparathyroidism-retardation-dysmorphism syndrome 10.2 IL1B IL6 TNF

Graphical network of the top 20 diseases related to Synovitis:



Diseases related to Synovitis

Symptoms & Phenotypes for Synovitis

UMLS symptoms related to Synovitis:


arthralgia, metatarsalgia, myalgia

MGI Mouse Phenotypes related to Synovitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.18 CD163 COMP CRP ICAM1 IL18 IL1B
2 homeostasis/metabolism MP:0005376 10.13 MMP1 MMP13 MMP3 SELE TNF TNFSF11
3 hematopoietic system MP:0005397 10.1 CD163 ICAM1 IL18 IL1B IL1RN IL6
4 immune system MP:0005387 10.03 IL6 MMP1 MMP3 SELE TNF TNFRSF11B
5 integument MP:0010771 9.61 IL18 IL1B IL1RN IL6 MMP13 SELE
6 skeleton MP:0005390 9.28 COMP IL1B IL1RN IL6 MMP13 MMP3

Drugs & Therapeutics for Synovitis

Drugs for Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 167)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2 185243-69-0
3
Methotrexate Approved Phase 4,Phase 3,Phase 2 1959-05-2, 59-05-2 126941
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 50-24-8 5755
6
Infliximab Approved Phase 4,Phase 2 170277-31-3
7
rituximab Approved Phase 4,Phase 3,Phase 2 174722-31-7 10201696
8
Certolizumab pegol Approved Phase 4,Phase 3 428863-50-7
9
Adalimumab Approved Phase 4,Phase 2 331731-18-1 16219006
10
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
11
Hydroxychloroquine Approved Phase 4,Phase 2 118-42-3 3652
12
Leflunomide Approved, Investigational Phase 4,Phase 3 75706-12-6 3899
13
Apremilast Approved, Investigational Phase 4,Phase 2 608141-41-9 11561674
14
Menthol Approved Phase 4,Early Phase 1 2216-51-5 16666
15
Sulfasalazine Approved Phase 4 599-79-1 5353980 5359476
16
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
17
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 54575, 6560146 143
18 Angiogenesis Inhibitors Phase 4,Phase 2
19 Angiogenesis Modulating Agents Phase 4,Phase 2
20 Analgesics Phase 4,Phase 3,Phase 2
21 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
22 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
23 Antiemetics Phase 4,Phase 3,Phase 2,Early Phase 1
24 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Early Phase 1
25 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
26 Antimetabolites Phase 4,Phase 3,Phase 2
27 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2
28 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Early Phase 1
29 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
30 Autonomic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
31 Dermatologic Agents Phase 4,Phase 3,Phase 2
32 Folic Acid Antagonists Phase 4,Phase 3,Phase 2
33 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
34 glucocorticoids Phase 4,Phase 3,Phase 2,Early Phase 1
35 Hormone Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
36 Hormones Phase 4,Phase 3,Phase 2,Early Phase 1
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
38 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
39 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
40 Methylprednisolone acetate Phase 4,Phase 3,Phase 2,Early Phase 1
41 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2,Early Phase 1
42 Neuroprotective Agents Phase 4,Phase 3,Phase 2,Early Phase 1
43 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
44 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Early Phase 1
45 Prednisolone acetate Phase 4,Phase 3,Phase 2,Early Phase 1
46 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2,Early Phase 1
47 Prednisolone phosphate Phase 4,Phase 3,Phase 2,Early Phase 1
48 Protective Agents Phase 4,Phase 3,Phase 2,Early Phase 1
49 Rheumatoid Factor Phase 4
50 Vitamin B Complex Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 145)
id Name Status NCT ID Phase
1 Intra-articular Bevacizumab for Recurrent Hemarthroses at Target Joints With Chronic Hemophilic Synovitis Unknown status NCT02060305 Phase 4
2 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
3 Remission Induction in Very Early Rheumatoid Arthritis Unknown status NCT00523692 Phase 4
4 Ultrasonographic Monitoring of Response to Infliximab in Patients With Rheumatoid Arthritis Unknown status NCT01282528 Phase 4
5 A Study of Tocilizumab Plus Non-biological DMARD in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Non-biological DMARDs Completed NCT01034397 Phase 4
6 A Pilot Study of MabThera (Rituximab) Evaluated by MRI in Patients With Rheumatoid Arthritis. Completed NCT00502853 Phase 4
7 A Comparison of Methotrexate Alone or Combined to Infliximab or to Pulse Methylprednisolone in Early Rheumatoid Arthritis: A Magnetic Resonance Imaging Study Completed NCT00396747 Phase 4
8 Certolizumab and Lower Extremity Lymph Flow in Rheumatoid Arthritis (RA) Completed NCT01098201 Phase 4
9 Musculoskeletal Ultrasound in Predicting Early Dose Titration With Tocilizumab Completed NCT01717859 Phase 4
10 Aiming for Remission in Rheumatoid Arthritis (RA) - the ARCTIC Trial Completed NCT01205854 Phase 4
11 Bone Mineral Density Changes Under Two Tibial Components in Total Knee Arthroplasty Completed NCT01764984 Phase 4
12 Prednisolone for Pain Reduction in Knee OA Completed NCT01619163 Phase 4
13 Study of the Optimal Protocol for Methotrexate and Adalimumab Combination Therapy in Early Rheumatoid Arthritis Completed NCT00420927 Phase 4
14 Dosing of Intra-articular Triamcinolone Hexacetonide for Knee Synovitis in Chronic Polyarthritis Recruiting NCT02437461 Phase 4
15 A Phase 4 Trial Assessing the ImPact of Residual Inflammation Detected Via Imaging TEchniques, Drug Levels and Patient Characteristics on the Outcome of Dose TaperIng of Adalimumab in Clinical Remission Rheumatoid ArThritis (RA) Subjects (PREDICTRA) Recruiting NCT02198651 Phase 4
16 Filling Bone Erosions: a Longitudinal Multicentric HR-pQCT Study of Subcutaneous Tocilizumab in Rheumatoid Arthritis Recruiting NCT02765074 Phase 4
17 Very Early Versus Delayed Etanercept in Patients With RA Recruiting NCT02433184 Phase 4
18 The Effect of Corticotrophin (ACTH) in Combination With Methotrexate in Newly Diagnosed Rheumatoid Arthritis Patients Active, not recruiting NCT01948388 Phase 4
19 Leflunomide Versus Sulfasalazine/Methotrexate in Rheumatoid Arthritis:an Ultrasound/Magnetic Resonance Imaging Study Terminated NCT01659242 Phase 4
20 A Study of Efficacy of Rituximab [Mabthera/Rituxan] in Patients With Rheumatoid Arthritis Using Magnetic Resonance Imaging of the Hand (RESONAR) Terminated NCT01117129 Phase 4
21 A Study of The Effect of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate on Articular Damage in The Hand in Patients With Moderate to Severe Rheumatoid Arthritis Who Have an Inadequate Response to Non-Biological DMARDs Withdrawn NCT01878318 Phase 4
22 Treatment With Apremilast in Patients With Psoriatic Arthritis Withdrawn NCT02558361 Phase 4
23 The Effect of Certolizumab Pegol on MRI Synovitis and Bone Edema in Rheumatoid Arthritis Patients Completed NCT01213017 Phase 3
24 Effect of Chondroitin Sulphate on Synovial Inflammation in Patients With Osteoarthritis of the Knee Completed NCT00604539 Phase 3
25 Intra-Articular Injection of Etanercept in Patient Suffering From Rheumatoid Arthritis : a Double-Blind Randomized Study Completed NCT00522184 Phase 3
26 A Study of Tocilizumab in Combination With Disease-Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Moderate to Severe Active Rheumatoid Arthritis With an Inadequate Response to DMARDs Completed NCT00996606 Phase 3
27 A Phase IIIb Study of BMS-188667 in Subjects With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate Completed NCT00420199 Phase 3
28 A Rheumatoid Arthritis Study to Assess Early Response to Abatacept+MTX as Defined by Improvement of Synovitis Measures by Power Doppler Ultrasonography Completed NCT00767325 Phase 3
29 Kineret (Anakinra), in Adult Patients With Colchicine-Resistant Familial Mediterranean Fever Completed NCT01705756 Phase 3
30 Does Etanercept Influence Tweak Modulation of Inflammation During Inflammatory Rheumatisms (Psoriatic Arthritis and Rheumatoid Arthritis)? Completed NCT02164214 Phase 3
31 Magnetic Resonance Image Verified Early Response to Certolizumab Pegol in Subjects With Active Rheumatoid Arthritis (RA) Completed NCT01235598 Phase 3
32 TORPEDO Study: A Study on Rapid Effect of Tocilizumab in Patients With Rheumatoid Arthritis With an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARDs) or Anti-TNF Completed NCT00977106 Phase 3
33 A Study of Rituximab (MabThera®/Rituxan®) in Patients With Rheumatoid Arthritis and Inadequate Response to Methotrexate Completed NCT00578305 Phase 3
34 An Open-Label Study of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Active Rheumatoid Arthritis Completed NCT01951170 Phase 3
35 A Study Of RoActemra/Actemra (Tocilizumab) in Tocilizumab-Naive Patients With Rheumatoid Arthritis With Inadequate Response to Non-Biologic Disease-Modifying Antirheumatic Drugs (DMARDs) or Biologic Therapy Completed NCT02001987 Phase 3
36 Colchicine for Symptom and Inflammation in Knee Osteoarthritis Completed NCT02176460 Phase 2, Phase 3
37 Addition of Rituximab to Leflunomide in Patients With Active Rheumatoid Arthritis Completed NCT01244958 Phase 3
38 Study of Power Doppler Ultrasound (PDUS) to Measure Response of Secukinumab Treatment in Patients With Active Psoriatic Arthritis (PsA) Recruiting NCT02662985 Phase 3
39 Abatacept Reversing Subclinical Inflammation as Measured by MRI in ACPA Positive Arthralgia Recruiting NCT02778906 Phase 3
40 Multicentre Canadian Study to Measure the Safety and Efficacy of Radiosynoviorthesis Recruiting NCT01615991 Phase 3
41 Dexamethasone Versus Ketorolac Injection for the Treatment of Local Inflammatory Hand and Upper Extremity Disorders Recruiting NCT02266433 Phase 3
42 PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS) Active, not recruiting NCT02371369 Phase 3
43 An Evaluation of the Optimal Dose of Tofacitinib Needed to Achieve Low Disease Activity (LDA) or Clinical Remission in Patients With Active Rheumatoid Arthritis (RA) as Measured From a Clinical and Structural Perspective Active, not recruiting NCT02566967 Phase 3
44 Double-Blinded Clinical Trial Using Apatone®B for Symptomatic Postoperative Total Joint Replacements Unknown status NCT01272830 Phase 2
45 Knee Osteoarthritis AND Methotrexate Use Unknown status NCT01927484 Phase 2
46 Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT) Completed NCT01261429 Phase 2
47 Evaluation of The Efficacy And Safety of Intra-Articular Etanercept in Patients With Refractory Knee Joint Synovitis Completed NCT00678782 Phase 2
48 Methotrexate Alone Versus Combination of Methotrexate and Subcutaneous Fludarabine for Severe Rheumatoid Arthritis: Safety, Tolerance and Efficacy Completed NCT00001677 Phase 2
49 Impact of Rituximab on MRI Evidence of Disease Activity in Patients With Moderate to Severe Rheumatoid Arthritis Completed NCT00425932 Phase 2
50 Hydroxychloroquine/Atorvastatin in the Treatment of Osteoarthritis (OA) of the Knee Completed NCT01645176 Phase 2

Search NIH Clinical Center for Synovitis

Cochrane evidence based reviews: synovitis

Genetic Tests for Synovitis

Genetic tests related to Synovitis:

id Genetic test Affiliating Genes
1 Synovitis 29

Anatomical Context for Synovitis

MalaCards organs/tissues related to Synovitis:

39
Bone, T Cells, Bone Marrow, Endothelial, Neutrophil, Testes, B Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Synovitis:

18
Synovial Membrane

Publications for Synovitis

Articles related to Synovitis:

(show top 50) (show all 1222)
id Title Authors Year
1
The relationship between synovitis quantified by an ultrasound 7-joint inflammation score and physical disability in rheumatoid arthritis - a cohort study. ( 28086960 )
2017
2
Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). ( 28057477 )
2017
3
Hereditary hemochromatosis arthropathy and Doppler ultrasound findings of synovitis. ( 28371912 )
2017
4
Calprotectin (S100A8/A9) has the strongest association with ultrasound-detected synovitis and predicts response to biologic treatment: results from a longitudinal study of patients with established rheumatoid arthritis. ( 28081709 )
2017
5
Level of agreement between three-dimensional volumetric ultrasound and real-time conventional ultrasound in the assessment of synovitis, tenosynovitis and erosions in rheumatoid arthritis patients. ( 27896420 )
2017
6
Hoffa's pad synovitis and pain sensitisation. ( 27015317 )
2016
7
Concordance between patient-reported joint symptoms, physician-examined arthritic signs and ultrasound-detected synovitis in rheumatoid arthritis. ( 27564121 )
2016
8
Peripheral eosinophilia in children with transient synovitis of the hip: 7-year experience from a single centre in New Zealand. ( 27084779 )
2016
9
Imaging for Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome. ( 27742022 )
2016
10
Associations between clinical evidence of inflammation and synovitis in symptomatic knee osteoarthritis: A substudy of the VIDEO trial. ( 27998036 )
2016
11
Successful ledipasvira88+a88sofosbuvir treatment of active synovitis in a rheumatoid arthritis patient with hepatitis C virus-related mixed cryoglobulinemia. ( 27848256 )
2016
12
Chemical vs. radioactive synoviorthesis for treatment of chronic haemophilic synovitis: Syrian experience. ( 27868370 )
2016
13
Pixel-by-Pixel Arterial Spin Labeling Blood Flow Pattern Variation Analysis for Discrimination of Rheumatoid Synovitis: A Pilot Study. ( 27149946 )
2016
14
Failed Radiation Synovectomy in Diseased Knee Joint with Missed Tuberculous Synovitis. ( 27651744 )
2016
15
Osteonecrosis of the femoral head associated with pigmented villonodular synovitis. ( 27928593 )
2016
16
Effect of a treat-to-target strategy based on methotrexate and intra-articular betamethasone with or without additional cyclosporin on MRI-assessed synovitis, osteitis, tenosynovitis, bone erosion, and joint space narrowing in early rheumatoid arthritis: results from a 2-year randomized double-blind placebo-controlled trial (CIMESTRA). ( 27775461 )
2016
17
Pigmented villonodular synovitis of the knee joint in a 5-year-old girl treated with combined open and arthroscopic surgery: a case report. ( 26919624 )
2016
18
Quantifying temporomandibular joint synovitis in children with juvenile idiopathic arthritis. ( 27110936 )
2016
19
Pigmented villonodular synovitis: a crowdsourcing study of two hundred and seventy two patients. ( 27169531 )
2016
20
Assessment of both articular synovitis and tenosynovitis by ultrasound is useful for evaluations of hand dysfunction in early rheumatoid arthritis patients. ( 27830970 )
2016
21
Synovitis assessed on static and dynamic contrast-enhanced magnetic resonance imaging and its association with pain in knee osteoarthritis: A cross-sectional study. ( 27161058 )
2016
22
Pigmented villonodular synovitis of proximal tibiofibular joint: Rare site of involvement treated with medical management. ( 28032093 )
2016
23
Locked hip joint: an uncommon presentation of localized pigmented villonodular synovitis. ( 27130398 )
2016
24
The preventive effect of two nutraceuticals on experimentally induced acute synovitis. ( 27554764 )
2016
25
Organ-specific radiation-induced cancer risk estimates due to radiotherapy for benign pigmented villonodular synovitis. ( 27499236 )
2016
26
Pigmented Villonodular Synovitis of the Knee Joint: A Case Report. ( 27843734 )
2016
27
Synovitis of sternoclavicular and peripheral joints can be detected by ultrasound in patients with SAPHO syndrome. ( 27846749 )
2016
28
Chronic Synovitis after Open Carpal Tunnel Decompression. ( 27454645 )
2016
29
Evidence of response to IL-6 inhibition in some cases of refractory spondyloarthritis-associated peripheral synovitis. ( 27059696 )
2016
30
Villonodular synovitis shoulder complicated by rotator cuff rupture. ( 27068614 )
2016
31
Evaluation of the dose-response relationship of oral robenacoxib in urate crystal-induced acute stifle synovitis in dogs. ( 27493016 )
2016
32
Active Foot Synovitis in Patients with Rheumatoid Arthritis: Patients with Foot Synovitis in Apparent Remission have Unstable Remission Status, Radiographic Progression and Worse Functional Outcomes. ( 26991415 )
2016
33
Evaluation of a Novel Semi-Automated Ultrasound System for the Detection of Synovitis: A Prospective Study involving 45 Patients with Rheumatoid Arthritis. ( 27921093 )
2016
34
A digital vascular malformation masquerading as synovitis. ( 26815764 )
2016
35
Arthroscopic surgical treatment of pigmented villonodular synovitis of the elbow: case report. ( 27517031 )
2016
36
Tumorlike Pigmented Villonodular Synovitis With Atypical Location: Appearance on 3-Phase 99mTc-MDP Bone Scan. ( 28005642 )
2016
37
Remitting Seronegative Symmetrical Synovitis with Pitting Oedema (RS3PE) Syndrome in a Chronic Kidney Disease Patient Undzergoing Haemodialysis. ( 27870229 )
2016
38
Synovitis, acne, pustulosis, hyperostosis and osteitis syndrome: a single centre study of a cohort of 164 patients. ( 26917545 )
2016
39
Current Systemic Treatment Options for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis: Targeting the CSF1/CSF1R Axis. ( 26820289 )
2016
40
PASE and EARP questionnaires for the identification of enthesitis, synovitis, and tenosynovitis in patients with psoriasis. ( 27567630 )
2016
41
Detection of antibodies to citrullinated tenascin-C in patients with early synovitis is associated with the development of rheumatoid arthritis. ( 27933208 )
2016
42
Subclinical ultrasound synovitis in a particular joint is associated with ultrasound evidence of bone erosions in that same joint in rheumatoid patients in clinical remission. ( 27192221 )
2016
43
Rheumatoid arthritis patients with fibromyalgic clinical features have significantly less synovitis as defined by power Doppler ultrasound. ( 27659057 )
2016
44
Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome Associated with Myeloma and Syndrome of Inappropriate Antidiuretic Hormone Secretion in an Elderly Man. ( 27550802 )
2016
45
Ultrasound power Doppler synovitis is associated with plasma IL-6 in established rheumatoid arthritis. ( 27026419 )
2016
46
Pigmented villonodular synovitis mimics metastases on fluorine 18 fluorodeoxyglucose position emission tomography-computed tomography. ( 27190776 )
2016
47
Musculoskeletal ultrasonography in the diagnosis of acute crystalline synovitis. ( 27439716 )
2016
48
Pigmented villonodular synovitis diagnosed during revision total knee arthroplasty for flexion instability and patellar fracture. ( 26810732 )
2016
49
Elevated synovial fluid concentration of adenosine triphosphate in dogs with osteoarthritis or sodium urate-induced synovitis of the stifle. ( 27432274 )
2016
50
Pigmented Villonodular Synovitis: A Comprehensive Review and Proposed Treatment Algorithm. ( 27509331 )
2016

Variations for Synovitis

Expression for Synovitis

Search GEO for disease gene expression data for Synovitis.

Pathways for Synovitis

Pathways related to Synovitis according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 CRP CXCL8 ICAM1 IL18 IL1B IL1RN
2
Show member pathways
13.35 CXCL8 ICAM1 IL18 IL1B IL1RN IL6
3
Show member pathways
13.03 CXCL8 IL18 IL1B IL1RN IL6 TNF
4
Show member pathways
12.87 CXCL8 ICAM1 IL1B IL6 TNF
5
Show member pathways
12.85 CXCL8 ICAM1 IL18 IL1B IL6 PRSS2
6
Show member pathways
12.8 COMP ICAM1 MMP1 MMP13 MMP3 PRSS2
7
Show member pathways
12.76 CXCL8 IL18 IL1B IL6 TNF
8 12.58 IL1B IL1RN TNF TNFSF11 VCAM1
9 12.44 ICAM1 IL6 TNF VCAM1
10
Show member pathways
12.42 ICAM1 TNFRSF11B TNFSF11 VCAM1
11
Show member pathways
12.39 CRP ICAM1 IL1B IL6 TNF
12
Show member pathways
12.37 CXCL8 IL1B IL6 MMP1 MMP13 MMP3
13
Show member pathways
12.3 CXCL8 IL1B IL6 TNF
14
Show member pathways
12.28 MMP1 MMP13 MMP3 TNFSF11
15 12.27 IL18 IL1B IL6 TNF
16 12.25 CXCL8 IL1B IL1RN IL6 TNF
17
Show member pathways
12.23 CXCL8 IL1B IL6 TNF
18
Show member pathways
12.22 CXCL8 IL18 IL1B IL6 TNF
19 12.17 ICAM1 IL1B SELE TNF VCAM1
20 12.1 IL1B TNF TNFRSF11B TNFSF11
21 12.08 CXCL8 ICAM1 IL1B IL6 TNF
22 12.01 ICAM1 IL1B IL6 MMP3 SELE TNF
23
Show member pathways
12 IL18 IL1B IL6 TNF
24
Show member pathways
11.98 MMP1 MMP13 MMP3 PRSS2 TNF
25 11.97 CXCL8 ICAM1 IL18 IL1B IL6 MMP1
26 11.95 CXCL8 IL1B IL6 TNF
27 11.94 CXCL8 ICAM1 IL1B IL6 SELE TNF
28 11.93 CXCL8 ICAM1 IL1B TNF TNFSF11 VCAM1
29 11.89 CXCL8 IL18 IL1B IL6
30 11.88 CXCL8 ICAM1 IL6 MMP1 SELE
31
Show member pathways
11.84 CRP IL6 TNFSF11
32 11.84 CD163 IL1B IL6 TNF
33
Show member pathways
11.83 TNF TNFRSF11B TNFSF11
34 11.83 CXCL8 IL1B IL6 TNF
35 11.81 IL18 IL1B TNF
36 11.79 ICAM1 IL6 TNF VCAM1
37 11.74 CXCL8 IL1B IL6 TNF
38 11.72 CXCL8 MMP1 MMP13 MMP3
39 11.66 CXCL8 IL18 IL1B IL6 TNF
40 11.63 CXCL8 IL6 SELE
41 11.6 CXCL8 IL6 MMP1
42 11.6 CXCL8 ICAM1 IL18 IL1B IL1RN IL6
43 11.56 ICAM1 IL6 TNF
44 11.56 IL18 IL1B TNF
45 11.56 IL1B IL6 TNF TNFRSF11B TNFSF11
46 11.53 ICAM1 SELE VCAM1
47 11.52 CXCL8 ICAM1 VCAM1
48
Show member pathways
11.51 IL1B TNF TNFRSF11B
49 11.5 COMP CXCL8 ICAM1 IL18 IL1B IL6
50 11.46 MMP1 MMP3 SELE

GO Terms for Synovitis

Cellular components related to Synovitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 CD163 COMP CRP CXCL8 IL18 IL1B
2 proteinaceous extracellular matrix GO:0005578 9.72 COMP MMP1 MMP13 MMP3 TNFRSF11B
3 extracellular matrix GO:0031012 9.65 COMP MMP1 MMP13 MMP3 PRSS2
4 external side of plasma membrane GO:0009897 9.55 CD163 ICAM1 IL6 TNF VCAM1
5 extracellular space GO:0005615 9.53 COMP CRP CXCL8 ICAM1 IL18 IL1B

Biological processes related to Synovitis according to GeneCards Suite gene sharing:

(show all 46)
id Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.92 ICAM1 IL1B MMP1 SELE TNF
2 cellular response to lipopolysaccharide GO:0071222 9.89 CXCL8 ICAM1 IL6 TNF
3 extracellular matrix organization GO:0030198 9.88 COMP ICAM1 TNF TNFRSF11B VCAM1
4 cellular response to interleukin-1 GO:0071347 9.87 CXCL8 ICAM1 IL6
5 cellular response to organic cyclic compound GO:0071407 9.86 IL18 IL1B TNF
6 cellular response to tumor necrosis factor GO:0071356 9.86 CXCL8 ICAM1 IL6 VCAM1
7 response to glucocorticoid GO:0051384 9.85 IL1RN IL6 TNF
8 defense response to Gram-positive bacterium GO:0050830 9.85 CRP IL6 TNF
9 positive regulation of JNK cascade GO:0046330 9.85 IL1B TNF TNFSF11
10 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.85 IL1B IL6 TNF TNFSF11
11 positive regulation of T cell proliferation GO:0042102 9.84 IL1B IL6 VCAM1
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.84 IL18 IL6 TNF
13 calcium-mediated signaling GO:0019722 9.82 CXCL8 SELE TNFSF11
14 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.81 ICAM1 SELE VCAM1
15 regulation of cell adhesion GO:0030155 9.8 CXCL8 ICAM1 IL18
16 positive regulation of interferon-gamma production GO:0032729 9.8 IL18 IL1B TNF
17 positive regulation of protein kinase B signaling GO:0051897 9.8 IL18 IL6 TNF TNFSF11
18 positive regulation of interleukin-6 production GO:0032755 9.79 IL1B IL6 TNF
19 acute-phase response GO:0006953 9.77 CD163 CRP IL6
20 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.77 ICAM1 IL1B IL6 TNF TNFSF11
21 extracellular matrix disassembly GO:0022617 9.76 MMP1 MMP13 MMP3 PRSS2
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.74 IL18 IL1B TNF
23 leukocyte cell-cell adhesion GO:0007159 9.71 ICAM1 SELE VCAM1
24 collagen catabolic process GO:0030574 9.71 MMP1 MMP13 MMP3 PRSS2
25 negative regulation of bone resorption GO:0045779 9.7 IL6 TNFRSF11B
26 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 IL1B TNF
27 cellular response to nutrient levels GO:0031669 9.69 ICAM1 IL6
28 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IL1B TNF
29 positive regulation of NF-kappaB import into nucleus GO:0042346 9.69 IL18 IL1B TNF
30 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.68 IL18 IL1B
31 positive regulation of T-helper 2 cell differentiation GO:0045630 9.67 IL18 IL6
32 regulation of establishment of endothelial barrier GO:1903140 9.66 IL1B TNF
33 growth plate cartilage development GO:0003417 9.65 COMP MMP13
34 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.65 IL6 TNF
35 membrane to membrane docking GO:0022614 9.64 ICAM1 VCAM1
36 positive regulation of fever generation GO:0031622 9.64 IL1B TNF
37 response to lipopolysaccharide GO:0032496 9.63 ICAM1 IL1B IL6 SELE TNFRSF11B VCAM1
38 sequestering of triglyceride GO:0030730 9.61 IL1B TNF
39 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.61 IL1RN IL6
40 leukocyte tethering or rolling GO:0050901 9.61 SELE TNF VCAM1
41 immune response GO:0006955 9.61 CXCL8 IL18 IL1B IL1RN IL6 PRG4
42 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.58 ICAM1 TNF
43 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 IL1B TNF
44 positive regulation of nitric oxide biosynthetic process GO:0045429 9.56 ICAM1 IL1B IL6 TNF
45 negative regulation of lipid storage GO:0010888 9.5 CRP IL6 TNF
46 inflammatory response GO:0006954 9.32 CD163 CRP CXCL8 IL18 IL1B IL1RN

Molecular functions related to Synovitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.63 COMP CRP MMP1 MMP13 MMP3 PRSS2
2 serine-type endopeptidase activity GO:0004252 9.56 MMP1 MMP13 MMP3 PRSS2
3 metalloendopeptidase activity GO:0004222 9.26 MMP1 MMP13 MMP3 PRSS2
4 cytokine activity GO:0005125 9.23 CXCL8 IL18 IL1B IL1RN IL6 TNF

Sources for Synovitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
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31 HMDB
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34 ICD10 via Orphanet
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60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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