Aliases & Classifications for Synovitis

Summaries for Synovitis

Disease Ontology : 12 A connective tissue disease that results_in inflammation located in synovial membrane that lines a synovial joint which causes pain and swelling.

MalaCards based summary : Synovitis is related to septic arthritis and palindromic rheumatism, and has symptoms including myalgia, metatarsalgia and arthralgia. An important gene associated with Synovitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Bevacizumab and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include synovial membrane, bone and t cells, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 72 Synovitis is the medical term for inflammation of the synovial membrane. This membrane lines joints that... more...

Related Diseases for Synovitis

Diseases related to Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 419)
# Related Disease Score Top Affiliating Genes
1 septic arthritis 30.4 CRP CXCL8 MMP3
2 palindromic rheumatism 30.1 CRP IL1B TNF
3 temporal arteritis 30.1 CRP IL1RN IL6
4 spondylarthropathy 30.0 CD163 TNF
5 angioimmunoblastic lymphadenopathy with dysproteinemia 30.0 IL6 TNF
6 prostatitis 29.9 CXCL8 IL1B IL6 TNF
7 reactive arthritis 29.8 CRP IL6 TNF
8 bronchiolitis obliterans 29.8 CXCL8 IL6 TNF
9 spondylitis 29.8 CRP IL6 TNF
10 bronchiolitis 29.7 CXCL8 IL6 TNF
11 osteomyelitis 29.7 CXCL8 IL1B IL1RN IL6 TNF TNFSF11
12 gingivitis 29.7 CXCL8 IL1B IL6 TNF
13 hydrarthrosis 29.7 IL1B IL1RN IL6 MMP3
14 relapsing polychondritis 29.7 COMP CRP IL6
15 fasciitis 29.7 CXCL8 IL18 IL6 TNF
16 spondyloarthropathy 29.7 IL6 MMP3 TNF TNFSF11
17 kaposi sarcoma 29.6 CXCL8 ICAM1 IL6 TNF
18 conjunctivitis 29.6 CXCL8 ICAM1 IL6
19 pneumonia 29.6 CRP CXCL8 IL1B IL6 TNF
20 arthritis 29.3 CXCL8 IL18 IL1B IL1RN IL6 MMP1
21 pleurisy 29.3 CRP CXCL8 ICAM1 TNF
22 familial mediterranean fever 29.2 CRP IL1B IL1RN TNF
23 chronic kidney failure 29.2 CRP ICAM1 IL6 VCAM1
24 arthropathy 28.9 COMP CRP PRG4 TNF TNFRSF11B TNFSF11
25 brucellosis 28.6 CRP CXCL8 IL18 IL1RN IL6 TNF
26 rheumatic disease 28.6 CD163 CRP IL1B TNF TNFRSF11B VCAM1
27 spondyloarthropathy 1 28.6 CRP IL1RN MMP3 TNF TNFRSF11B TNFSF11
28 psoriasis 28.5 CXCL8 ICAM1 IL18 IL1B IL6 SELE
29 psoriatic arthritis 28.0 COMP CRP IL1B MMP1 MMP3 SELE
30 bone inflammation disease 27.9 COMP CRP CXCL8 IL1B IL1RN IL6
31 systemic lupus erythematosus 27.7 CRP ICAM1 IL18 IL1B IL6 SELE
32 osteoarthritis 27.7 COMP CRP CXCL8 IL1B IL6 MMP1
33 rheumatoid arthritis 27.1 COMP CRP CXCL8 ICAM1 IL18 IL1B
34 inflammatory bowel disease 26.2 CRP CXCL8 ICAM1 IL18 IL1B IL1RN
35 pigmented villonodular synovitis 12.6
36 villonodular synovitis 12.5
37 gonococcal synovitis 12.0
38 talo-patello-scaphoid osteolysis, synovitis, and short fourth metacarpals 11.9
39 sapho syndrome 11.9
40 noonan syndrome 1 11.7
41 intermittent hydrarthrosis 11.2
42 legg-calve-perthes disease 11.2
43 eosinophilic fasciitis 11.2
44 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 11.2
45 blau syndrome 11.0
46 noonan syndrome 4 10.9
47 superior limbic keratoconjunctivitis 10.6 MMP1 MMP3
48 polyposis, gastric 10.6 IL1B TNF
49 scorpion envenomation 10.5 IL6 TNF
50 kashin-beck disease 10.5 IL1B MMP1 TNF

Graphical network of the top 20 diseases related to Synovitis:



Diseases related to Synovitis

Symptoms & Phenotypes for Synovitis

UMLS symptoms related to Synovitis:


myalgia, metatarsalgia, arthralgia

MGI Mouse Phenotypes related to Synovitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.25 COMP IL1RN CRP ICAM1 IL6 IL18
2 growth/size/body region MP:0005378 10.15 COMP IL1RN ICAM1 IL6 IL18 IL1B
3 cellular MP:0005384 10.14 COMP IL1RN ICAM1 IL6 IL18 CD163
4 homeostasis/metabolism MP:0005376 10.13 COMP IL1RN CRP ICAM1 IL6 IL18
5 hematopoietic system MP:0005397 10.1 IL1RN ICAM1 IL6 IL18 IL1B CD163
6 immune system MP:0005387 10.03 IL1RN CRP ICAM1 IL6 IL18 MMP1
7 integument MP:0010771 9.61 IL1RN ICAM1 IL6 IL18 MMP13 IL1B
8 skeleton MP:0005390 9.28 IL1B COMP IL1RN IL6 MMP3 TNF

Drugs & Therapeutics for Synovitis

Drugs for Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 175)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2 185243-69-0
3
Methotrexate Approved Phase 4,Phase 3,Phase 2 1959-05-2, 59-05-2 126941
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 50-24-8 5755
6
Infliximab Approved Phase 4,Phase 2 170277-31-3
7
Hydroxychloroquine Approved Phase 4,Phase 2 118-42-3 3652
8
Menthol Approved Phase 4,Early Phase 1 2216-51-5 16666
9
Sulfasalazine Approved Phase 4 599-79-1 5359476 5353980
10
rituximab Approved Phase 4,Phase 3,Phase 2 174722-31-7 10201696
11
Certolizumab pegol Approved Phase 4,Phase 3 428863-50-7
12
Adalimumab Approved Phase 4,Phase 2 331731-18-1 16219006
13
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
14
Abatacept Approved Phase 4,Phase 3,Phase 2,Phase 1 332348-12-6 10237
15
Leflunomide Approved, Investigational Phase 4,Phase 3 75706-12-6 3899
16
Apremilast Approved, Investigational Phase 4,Phase 2 608141-41-9 11561674
17
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
18
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
19
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 143 6006
20 Angiogenesis Inhibitors Phase 4,Phase 2
21 Angiogenesis Modulating Agents Phase 4,Phase 2
22 Analgesics Phase 4,Phase 3,Phase 2
23 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
24 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
25 Antiemetics Phase 4,Phase 3,Phase 2,Early Phase 1
26 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Early Phase 1
27 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
28 Antimetabolites Phase 4,Phase 3,Phase 2
29 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2
30 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Early Phase 1
31 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
32 Autonomic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
33 Dermatologic Agents Phase 4,Phase 3,Phase 2
34 Folic Acid Antagonists Phase 4,Phase 3,Phase 2
35 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
36 glucocorticoids Phase 4,Phase 3,Phase 2,Early Phase 1
37 Hormone Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
38 Hormones Phase 4,Phase 3,Phase 2,Early Phase 1
39 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
40 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
41 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
42 Methylprednisolone acetate Phase 4,Phase 3,Phase 2,Early Phase 1
43 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2,Early Phase 1
44 Neuroprotective Agents Phase 4,Phase 3,Phase 2,Early Phase 1
45 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
46 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Early Phase 1
47 Prednisolone acetate Phase 4,Phase 3,Phase 2,Early Phase 1
48 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2,Early Phase 1
49 Prednisolone phosphate Phase 4,Phase 3,Phase 2,Early Phase 1
50 Protective Agents Phase 4,Phase 3,Phase 2,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 155)

# Name Status NCT ID Phase Drugs
1 Intra-articular Bevacizumab for Recurrent Hemarthroses at Target Joints With Chronic Hemophilic Synovitis Unknown status NCT02060305 Phase 4 Bevacizumab intra-articular injection
2 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
3 Remission Induction in Very Early Rheumatoid Arthritis Unknown status NCT00523692 Phase 4 Etanercept, methotrexate and depomedrone;depemedrone
4 Ultrasonographic Monitoring of Response to Infliximab in Patients With Rheumatoid Arthritis Unknown status NCT01282528 Phase 4
5 Very Early Versus Delayed Etanercept in Patients With RA Unknown status NCT02433184 Phase 4 Etanercept;Methotrexate;Sulfasalazine;Hydroxychloroquine;Etanercept;Methotrexate
6 A Study of Tocilizumab Plus Non-biological DMARD in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Non-biological DMARDs Completed NCT01034397 Phase 4 tocilizumab [RoActemra/Actemra];placebo;non-biological DMARDs
7 A Pilot Study of MabThera (Rituximab) Evaluated by MRI in Patients With Rheumatoid Arthritis. Completed NCT00502853 Phase 4 rituximab [MabThera/Rituxan];Methotrexate
8 A Comparison of Methotrexate Alone or Combined to Infliximab or to Pulse Methylprednisolone in Early Rheumatoid Arthritis: A Magnetic Resonance Imaging Study Completed NCT00396747 Phase 4 Infliximab, methylprednisolone, methotrexate;Methotrexate;Methotrexate + Methylprednisolone;Methotrexate + Infliximab
9 Certolizumab and Lower Extremity Lymph Flow in Rheumatoid Arthritis (RA) Completed NCT01098201 Phase 4 Certolizumab
10 Musculoskeletal Ultrasound in Predicting Early Dose Titration With Tocilizumab Completed NCT01717859 Phase 4 Tocilizumab
11 Aiming for Remission in Rheumatoid Arthritis (RA) - the ARCTIC Trial Completed NCT01205854 Phase 4
12 Bone Mineral Density Changes Under Two Tibial Components in Total Knee Arthroplasty Completed NCT01764984 Phase 4
13 Prednisolone for Pain Reduction in Knee OA Completed NCT01619163 Phase 4 Placebo;Prednisolone
14 Study of the Optimal Protocol for Methotrexate and Adalimumab Combination Therapy in Early Rheumatoid Arthritis Completed NCT00420927 Phase 4 methotrexate
15 Filling Bone Erosions: a Longitudinal Multicentric HR-pQCT Study of Subcutaneous Tocilizumab in Rheumatoid Arthritis Recruiting NCT02765074 Phase 4 subcutaneous tocilizumab
16 Dosing of Intra-articular Triamcinolone Hexacetonide for Knee Synovitis in Chronic Polyarthritis Active, not recruiting NCT02437461 Phase 4 Triamcinolone hexacetonide
17 The Effect of Corticotrophin (ACTH) in Combination With Methotrexate in Newly Diagnosed Rheumatoid Arthritis Patients Active, not recruiting NCT01948388 Phase 4 corticotrophin 80 units
18 A Phase 4 Trial Assessing the ImPact of Residual Inflammation Detected Via Imaging TEchniques, Drug Levels and Patient Characteristics on the Outcome of Dose TaperIng of Adalimumab in Clinical Remission Rheumatoid ArThritis (RA) Subjects (PREDICTRA) Active, not recruiting NCT02198651 Phase 4 Adalimumab
19 The Comparative Study of Intra-articular Injection of Tocilizumab and Compound Betamethasone Not yet recruiting NCT03215407 Phase 4 Intra-articular Tocilizumab;Intra-articular Compound Betamethasone
20 Abatacept vs Tocilizumab for the Treatment of RA in TNF Alpha Inhibitor Inadequate Responders Not yet recruiting NCT03227419 Phase 4 Tocilizumab Prefilled Syringe;Abatacept Prefilled Syringe
21 Leflunomide Versus Sulfasalazine/Methotrexate in Rheumatoid Arthritis:an Ultrasound/Magnetic Resonance Imaging Study Terminated NCT01659242 Phase 4 Methotrexate plus sulfasalazine;Leflunomide
22 A Study of Efficacy of Rituximab [Mabthera/Rituxan] in Patients With Rheumatoid Arthritis Using Magnetic Resonance Imaging of the Hand (RESONAR) Terminated NCT01117129 Phase 4 rituximab [MabThera/Rituxan];placebo;methotrexate;rituximab [Mabthera/Rituxan]
23 A Study of The Effect of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate on Articular Damage in The Hand in Patients With Moderate to Severe Rheumatoid Arthritis Who Have an Inadequate Response to Non-Biological DMARDs Withdrawn NCT01878318 Phase 4 methotrexate;tocilizumab [RoActemra/Actemra]
24 Treatment With Apremilast in Patients With Psoriatic Arthritis Withdrawn NCT02558361 Phase 4 Treatment with Apremilast
25 The Effect of Certolizumab Pegol on MRI Synovitis and Bone Edema in Rheumatoid Arthritis Patients Completed NCT01213017 Phase 3 certolizumab pegol
26 Effect of Chondroitin Sulphate on Synovial Inflammation in Patients With Osteoarthritis of the Knee Completed NCT00604539 Phase 3 Chondroitin sulphate (Condrosan);Placebo
27 Intra-Articular Injection of Etanercept in Patient Suffering From Rheumatoid Arthritis : a Double-Blind Randomized Study Completed NCT00522184 Phase 3
28 A Study of Tocilizumab in Combination With Disease-Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Moderate to Severe Active Rheumatoid Arthritis With an Inadequate Response to DMARDs Completed NCT00996606 Phase 3 DMARDs;Tocilizumab
29 A Phase IIIb Study of BMS-188667 in Subjects With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate Completed NCT00420199 Phase 3 Abatacept;Placebo
30 A Rheumatoid Arthritis Study to Assess Early Response to Abatacept+MTX as Defined by Improvement of Synovitis Measures by Power Doppler Ultrasonography Completed NCT00767325 Phase 3 Abatacept;Methotrexate
31 Kineret (Anakinra), in Adult Patients With Colchicine-Resistant Familial Mediterranean Fever Completed NCT01705756 Phase 3 Kineret
32 Does Etanercept Influence Tweak Modulation of Inflammation During Inflammatory Rheumatisms (Psoriatic Arthritis and Rheumatoid Arthritis)? Completed NCT02164214 Phase 3 etanercept Treatment
33 Magnetic Resonance Image Verified Early Response to Certolizumab Pegol in Subjects With Active Rheumatoid Arthritis (RA) Completed NCT01235598 Phase 3
34 TORPEDO Study: A Study on Rapid Effect of Tocilizumab in Patients With Rheumatoid Arthritis With an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARDs) or Anti-TNF Completed NCT00977106 Phase 3 tocilizumab [RoActemra/Actemra];placebo;tocilizumab [RoActemra/Actemra]
35 A Study of Rituximab (MabThera®/Rituxan®) in Patients With Rheumatoid Arthritis and Inadequate Response to Methotrexate Completed NCT00578305 Phase 3 Placebo;Methylprednisolone;Methotrexate;Folic acid or folate
36 An Open-Label Study of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Active Rheumatoid Arthritis Completed NCT01951170 Phase 3 Tocilizumab
37 A Study Of RoActemra/Actemra (Tocilizumab) in Tocilizumab-Naive Patients With Rheumatoid Arthritis With Inadequate Response to Non-Biologic Disease-Modifying Antirheumatic Drugs (DMARDs) or Biologic Therapy Completed NCT02001987 Phase 3 tocilizumab [RoActemra/Actemra]
38 Colchicine for Symptom and Inflammation in Knee Osteoarthritis Completed NCT02176460 Phase 2, Phase 3 Colchicine;Placebo
39 Addition of Rituximab to Leflunomide in Patients With Active Rheumatoid Arthritis Completed NCT01244958 Phase 3 Placebo
40 Study of Power Doppler Ultrasound (PDUS) to Measure Response of Secukinumab Treatment in Patients With Active Psoriatic Arthritis (PsA) Recruiting NCT02662985 Phase 3 AIN457 (secukinumab);Placebo
41 Abatacept Reversing Subclinical Inflammation as Measured by MRI in ACPA Positive Arthralgia Recruiting NCT02778906 Phase 3 Abatacept;Placebo
42 Dexamethasone Versus Ketorolac Injection for the Treatment of Local Inflammatory Hand and Upper Extremity Disorders Recruiting NCT02266433 Phase 3 Ketorolac;Dexamethasone
43 PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS) Active, not recruiting NCT02371369 Phase 3 PLX3397;Placebo
44 An Evaluation of the Optimal Dose of Tofacitinib Needed to Achieve Low Disease Activity (LDA) or Clinical Remission in Patients With Active Rheumatoid Arthritis (RA) as Measured From a Clinical and Structural Perspective Active, not recruiting NCT02566967 Phase 3 tofacitinib
45 Multicentre Canadian Study to Measure the Safety and Efficacy of Radiosynoviorthesis Active, not recruiting NCT01615991 Phase 3 Radiosynoviorthesis
46 Knee Osteoarthritis AND Methotrexate Use Unknown status NCT01927484 Phase 2 25 mg/week oral methotrexate tablets;25mg/week oral placebo tablets
47 Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT) Completed NCT01261429 Phase 2 Tasigna
48 Evaluation of The Efficacy And Safety of Intra-Articular Etanercept in Patients With Refractory Knee Joint Synovitis Completed NCT00678782 Phase 2 etanercept;placebo
49 Methotrexate Alone Versus Combination of Methotrexate and Subcutaneous Fludarabine for Severe Rheumatoid Arthritis: Safety, Tolerance and Efficacy Completed NCT00001677 Phase 2 Methotrexate;Fludarabine
50 Impact of Rituximab on MRI Evidence of Disease Activity in Patients With Moderate to Severe Rheumatoid Arthritis Completed NCT00425932 Phase 2

Search NIH Clinical Center for Synovitis

Cochrane evidence based reviews: synovitis

Genetic Tests for Synovitis

Genetic tests related to Synovitis:

# Genetic test Affiliating Genes
1 Synovitis 28

Anatomical Context for Synovitis

The Foundational Model of Anatomy Ontology organs/tissues related to Synovitis:

18
Synovial Membrane

MalaCards organs/tissues related to Synovitis:

38
Bone, T Cells, Bone Marrow, Endothelial, Monocytes, Liver, Neutrophil

Publications for Synovitis

Articles related to Synovitis:

(show top 50) (show all 1284)
# Title Authors Year
1
Adalimumab as a successful treatment for acne fulminans and bilateral acute sacroiliitis with hip synovitis complicating isotretinoin therapy. ( 29284764 )
2018
2
Pigmented villonodular synovitis in pediatric population: review of literature and a case report. ( 29343257 )
2018
3
Clinical utility of eco-color-power Doppler ultrasonography and contrast enhanced magnetic resonance imaging for interpretation and quantification of joint synovitis: a review. ( 29350637 )
2018
4
Resolution of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) during Nivolumab therapy for non-small cell lung cancer: a case report. ( 29402438 )
2018
5
What does power Doppler signal indicate in rheumatoid synovitis? A point of view from synovial histopathology. ( 29366644 )
2018
6
Pigmented Villonodular Synovitis: A Close Mimic of Metastasis on<sup>18</sup>F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. ( 29430127 )
2018
7
Feasibility of photoacoustic/ultrasound imaging of synovitis in finger joints using a point-of-care system. ( 28913168 )
2017
8
An unusual case of diffuse pigmented villonodular synovitis of the shoulder: A multidisciplinary approach with arthroscopic synovectomy and adjuvant radiotherapy. ( 28638690 )
2017
9
Associations Between Knee Effusion-synovitis and Joint Structural Changes in Patients with Knee Osteoarthritis. ( 28864651 )
2017
10
Pigmented villonodular synovitis of the knee: A retrospective analysis of 214 cases at a UK tertiary referral centre. ( 28442184 )
2017
11
Total knee replacement in patients with diffuse villonodular synovitis. ( 29062829 )
2017
12
Comment on: Hereditary hemochromatosis arthropathy and Doppler ultrasound findings of synovitis. ( 29228359 )
2017
13
Ratiometric Optical Imaging of Subclinical Inflammation with a Thrombin-cleavable Probe: A Future Tool for the In Vivo Visualization of Clinically Silent Synovitis? ( 28898572 )
2017
14
Intra-articular Localized Haemangioma of the Knee Mimicking Localized Pigmented Villonodular Synovitis: A Case Report. ( 28435577 )
2017
15
Arthroscopic treatment of intra-artricularly localised pigmented villonodular synovitis of the ankle: 4 cases with long-term follow-up. ( 29202997 )
2017
16
Platelet-rich plasma intra-articular injections for haemophilic synovitis: Scientific knowledge does not support its use. ( 28840633 )
2017
17
Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data. ( 29258575 )
2017
18
Functional complement activity is decisive for the development of chronic synovitis, osteophyte formation and processes of cell senescence in zymosan-induced arthritis. ( 28860038 )
2017
19
Localized pigmented villonodular synovitis of posterior compartment of the knee. ( 28847242 )
2017
20
Frondlike Synovitis on MRI and Correlation With Polyethylene Surface Damage of Total Knee Arthroplasty. ( 28777663 )
2017
21
Flexor Hallucis Longus Tenosynovitis and First Metatarsophalangeal Synovitis After Penetrating Nail Prick Injury: Treated by Zone 3 Flexor Hallucis Longus Tendoscopy and Metatarsosesamoid Arthroscopy. ( 28580263 )
2017
22
SAPHO Syndrome: Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis. ( 28250311 )
2017
23
Successful treatment of a childhood synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome with subcutaneous methotrexate: A case report. ( 29276872 )
2017
24
Pigmented Villonodular Synovitis - Various Manifestations, Inconsistent Terminology and Treatment. Cases Study. ( 28436371 )
2017
25
The relationship between synovitis quantified by an ultrasound 7-joint inflammation score and physical disability in rheumatoid arthritis - a cohort study. ( 28086960 )
2017
26
Para-articular extraskeletal chondroma mimicking first metatarsophalangeal synovitis. ( 28828128 )
2017
27
Localized pigmented villonodular synovitis of the ankle: Expect the unexpected. ( 28159047 )
2017
28
Diffuse pigmented villonodular synovitis in knee joint: diagnosis and treatment. ( 28884104 )
2017
29
Open and Arthroscopic with Mini-Open Surgical Hip Approaches for Treatment of Pigmented Villonodular Synovitis and Concomitant Hip Pathology. ( 28326214 )
2017
30
A Case of Atypical Synovitis-Acne-Pustulosis-Hyperostosis-Osteitis (SAPHO) Syndrome Presenting With Osteomyelitis of the Clavicle. ( 29323824 )
2017
31
Increased synovial lipodystrophy induced by high fat diet aggravates synovitis in experimental osteoarthritis. ( 29191221 )
2017
32
SOCS3 participates in cholinergic pathway regulation of synovitis in rheumatoid arthritis. ( 28914550 )
2017
33
Surgical treatment for diffused-type giant cell tumor (pigmented villonodular synovitis) about the ankle joint. ( 29137617 )
2017
34
PIGMENTED VILLONODULAR SYNOVITIS IN A RETICULATED GIRAFFE (GIRAFFA CAMELOPARDALIS). ( 28749260 )
2017
35
Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) Syndrome with Significant Bilateral Pleural Effusions. ( 28924111 )
2017
36
Calprotectin (S100A8/A9) has the strongest association with ultrasound-detected synovitis and predicts response to biologic treatment: results from a longitudinal study of patients with established rheumatoid arthritis. ( 28081709 )
2017
37
With a biomechanical treatment in knee osteoarthritis, less knee pain did not correlate with synovitis reduction. ( 28797238 )
2017
38
Scoring ultrasound synovitis in rheumatoid arthritis: a EULAR-OMERACT ultrasound taskforce-Part 2: reliability and application to multiple joints of a standardised consensus-based scoring system. ( 28948984 )
2017
39
Long-term outcome of knee arthroplasty in the setting of pigmented villonodular synovitis. ( 28552192 )
2017
40
Long-Term Outcome of Hip Arthroplasty in the Setting of Pigmented Villonodular Synovitis. ( 29352684 )
2017
41
A Case of Paraneoplastic Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome Improved by Chemotherapy. ( 29430239 )
2017
42
Long-term outcome of pigmented villonodular synovitis of the hip after joint preserving therapy. ( 29282525 )
2017
43
Is synovitis detected on non-contrast-enhanced magnetic resonance imaging associated with serum biomarkers and clinical signs of effusion? Data from the Osteoarthritis Initiative. ( 28929915 )
2017
44
Systematic Arthroscopic Treatment of Diffuse Pigmented Villonodular Synovitis in the Knee. ( 29354472 )
2017
45
Diffuse Pigmented Villonodular Synovitis as a Rare Cause of Graft Failure Following Anterior Cruciate Ligament Reconstruction. ( 28776631 )
2017
46
Could autophagy induced by misfolded mutant alpha-1-antitrypsin Z in synovitis explain the association of ATZ with increased ACPA production in RA? ( 28881422 )
2017
47
Localized pigmented villonodular synovitis in a child knee. ( 28291439 )
2017
48
Scoring ultrasound synovitis in rheumatoid arthritis: a EULAR-OMERACT ultrasound taskforce-Part 1: definition and development of a standardised, consensus-based scoring system. ( 28948983 )
2017
49
Proliferative Synovitis of the Shoulder Bursae is a Key Feature for Discriminating Elderly Onset Rheumatoid Arthritis Mimicking Polymyalgia Rheumatica From Polymyalgia Rheumatica. ( 29242702 )
2017
50
A case of bronchiolitis obliterans organising pneumonia associated with SAPHO (synovitis-acne-pustulosis-hyperostosis-osteitis) syndrome. ( 28765183 )
2017

Variations for Synovitis

Expression for Synovitis

Search GEO for disease gene expression data for Synovitis.

Pathways for Synovitis

Pathways related to Synovitis according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 CRP CXCL8 ICAM1 IL18 IL1B IL1RN
2
Show member pathways
13.35 CXCL8 ICAM1 IL18 IL1B IL1RN IL6
3
Show member pathways
13.02 CXCL8 IL18 IL1B IL1RN IL6 TNF
4
Show member pathways
12.87 CXCL8 ICAM1 IL1B IL6 TNF
5
Show member pathways
12.86 CXCL8 ICAM1 IL18 IL1B IL6 PRSS2
6
Show member pathways
12.8 COMP ICAM1 MMP1 MMP13 MMP3 PRSS2
7
Show member pathways
12.76 CXCL8 IL18 IL1B IL6 TNF
8 12.61 IL1B IL1RN TNF TNFSF11 VCAM1
9 12.45 ICAM1 IL6 TNF VCAM1
10
Show member pathways
12.43 ICAM1 TNFRSF11B TNFSF11 VCAM1
11
Show member pathways
12.4 CRP ICAM1 IL1B IL6 TNF
12
Show member pathways
12.37 CXCL8 IL1B IL6 MMP1 MMP13 MMP3
13
Show member pathways
12.31 CXCL8 IL1B IL6 TNF
14
Show member pathways
12.29 MMP1 MMP13 MMP3 TNFSF11
15 12.28 IL18 IL1B IL6 TNF
16
Show member pathways
12.26 CXCL8 ICAM1 MMP1 MMP13 MMP3 PRG4
17 12.25 CXCL8 IL1B IL1RN IL6 TNF
18
Show member pathways
12.23 CXCL8 IL1B IL6 TNF
19
Show member pathways
12.22 CXCL8 IL18 IL1B IL6 TNF
20 12.17 ICAM1 IL1B SELE TNF VCAM1
21 12.1 IL1B TNF TNFRSF11B TNFSF11
22 12.08 CXCL8 ICAM1 IL1B IL6 TNF
23 12.07 ICAM1 MMP13 MMP3 VCAM1
24 12.01 ICAM1 IL1B IL6 MMP3 SELE TNF
25
Show member pathways
12 IL18 IL1B IL6 TNF
26
Show member pathways
11.98 MMP1 MMP13 MMP3 PRSS2 TNF
27 11.97 CXCL8 ICAM1 IL18 IL1B IL6 MMP1
28 11.96 CXCL8 IL1B IL6 TNF
29 11.94 CXCL8 ICAM1 IL1B IL6 SELE TNF
30 11.93 CXCL8 ICAM1 IL1B TNF TNFSF11 VCAM1
31 11.9 CXCL8 IL18 IL1B IL6
32 11.88 CXCL8 ICAM1 IL6 MMP1 SELE
33
Show member pathways
11.85 CRP IL6 TNFSF11
34 11.84 CXCL8 IL1B IL6 TNF
35 11.83 CD163 IL1B IL6 TNF
36
Show member pathways
11.82 TNF TNFRSF11B TNFSF11
37 11.81 IL18 IL1B TNF
38 11.78 ICAM1 IL6 TNF VCAM1
39 11.75 CXCL8 IL1B IL6 TNF
40 11.73 CXCL8 MMP1 MMP13 MMP3
41 11.66 CXCL8 IL18 IL1B IL6 TNF
42 11.64 CXCL8 IL6 SELE
43 11.6 CXCL8 IL6 MMP1
44 11.6 CXCL8 ICAM1 IL18 IL1B IL1RN IL6
45 11.57 ICAM1 IL6 TNF
46 11.57 IL18 IL1B TNF
47 11.56 IL1B IL6 TNF TNFRSF11B TNFSF11
48 11.54 ICAM1 SELE VCAM1
49 11.52 CXCL8 ICAM1 VCAM1
50
Show member pathways
11.51 IL1B TNF TNFRSF11B

GO Terms for Synovitis

Cellular components related to Synovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 CD163 COMP CRP CXCL8 IL18 IL1B
2 extracellular matrix GO:0031012 9.7 COMP ICAM1 MMP1 MMP13 MMP3 PRG4
3 proteinaceous extracellular matrix GO:0005578 9.65 COMP MMP1 MMP13 MMP3 TNFRSF11B
4 external side of plasma membrane GO:0009897 9.62 CD163 ICAM1 TNF VCAM1
5 extracellular space GO:0005615 9.53 COMP CRP CXCL8 ICAM1 IL18 IL1B

Biological processes related to Synovitis according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.89 ICAM1 IL1B MMP1 SELE TNF
2 extracellular matrix organization GO:0030198 9.88 COMP ICAM1 TNF TNFRSF11B VCAM1
3 cellular response to lipopolysaccharide GO:0071222 9.87 CXCL8 ICAM1 IL6 TNF
4 cellular response to organic cyclic compound GO:0071407 9.86 IL18 IL1B TNF
5 positive regulation of JNK cascade GO:0046330 9.85 IL1B TNF TNFSF11
6 response to glucocorticoid GO:0051384 9.85 IL1RN IL6 TNF
7 positive regulation of T cell proliferation GO:0042102 9.85 IL1B IL6 VCAM1
8 positive regulation of DNA binding transcription factor activity GO:0051091 9.84 IL1B IL6 TNF TNFSF11
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.83 IL18 IL6 TNF
10 calcium-mediated signaling GO:0019722 9.83 CXCL8 SELE TNFSF11
11 response to lipopolysaccharide GO:0032496 9.83 ICAM1 IL1B SELE TNFRSF11B VCAM1
12 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.81 ICAM1 SELE VCAM1
13 positive regulation of interleukin-6 production GO:0032755 9.81 IL1B IL6 TNF
14 regulation of cell adhesion GO:0030155 9.79 CXCL8 ICAM1 IL18
15 positive regulation of interferon-gamma production GO:0032729 9.78 IL18 IL1B TNF
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 ICAM1 IL1B TNF
17 extracellular matrix disassembly GO:0022617 9.76 MMP1 MMP13 MMP3 PRSS2
18 regulation of receptor activity GO:0010469 9.76 CXCL8 IL18 IL1B IL1RN IL6 TNF
19 acute-phase response GO:0006953 9.75 CD163 CRP IL6
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.72 IL18 IL1B TNF
21 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.72 ICAM1 IL1B IL6 TNF TNFSF11
22 leukocyte cell-cell adhesion GO:0007159 9.7 ICAM1 SELE VCAM1
23 negative regulation of bone resorption GO:0045779 9.69 IL6 TNFRSF11B
24 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.69 IL1B TNF
25 neutrophil activation GO:0042119 9.69 CXCL8 IL18
26 positive regulation of NF-kappaB import into nucleus GO:0042346 9.69 IL18 IL1B TNF
27 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.68 IL18 IL1B
28 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
29 regulation of establishment of endothelial barrier GO:1903140 9.67 IL1B TNF
30 collagen catabolic process GO:0030574 9.67 MMP1 MMP13 MMP3 PRSS2
31 interleukin-6 production GO:0032635 9.66 IL18 IL1B
32 growth plate cartilage development GO:0003417 9.66 COMP MMP13
33 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.64 ICAM1 TNF
34 membrane to membrane docking GO:0022614 9.63 ICAM1 VCAM1
35 fever generation GO:0001660 9.62 IL1B IL1RN
36 positive regulation of fever generation GO:0031622 9.62 IL1B TNF
37 immune response GO:0006955 9.61 CXCL8 IL18 IL1B IL1RN IL6 PRG4
38 sequestering of triglyceride GO:0030730 9.59 IL1B TNF
39 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.58 IL1RN IL6
40 leukocyte tethering or rolling GO:0050901 9.58 SELE TNF VCAM1
41 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.56 IL1B TNF
42 negative regulation of lipid storage GO:0010888 9.43 CRP IL6 TNF
43 inflammatory response GO:0006954 9.32 CD163 CRP CXCL8 IL18 IL1B IL1RN
44 positive regulation of gene expression GO:0010628 10.04 CRP IL18 IL1B IL6 TNF

Molecular functions related to Synovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.46 MMP1 MMP13 MMP3 PRSS2
2 metalloendopeptidase activity GO:0004222 9.26 MMP1 MMP13 MMP3 PRSS2
3 cytokine activity GO:0005125 9.23 CXCL8 IL18 IL1B IL1RN IL6 TNF

Sources for Synovitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
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29 HGMD
30 HMDB
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32 ICD10
33 ICD10 via Orphanet
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60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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