Synovitis malady

Disease Ontology: A connective tissue disease that results in inflammation located in synovial membrane that lines a synovial joint which causes pain and swelling.⁶

MalaCards: Synovitis, also known as synovitis (disorder), is related to arthritis and pigmented villonodular synovitis. An important gene associated with Synovitis is CASP1 (caspase 1, apoptosis-related cysteine peptidase), and among its related pathways are Activation of Matrix Metalloproteinases and Malaria. The compounds procollagen and n-formylmethionyl-leucylphenylalanine have been mentioned in the context of this disorder. Affiliated tissues include synovial membrane, whole blood and skin, and related mouse phenotypes are respiratory system and craniofacial.

Wikipedia: Synovitis is the medical term for inflammation of the synovial membrane. This membrane lines joints...⁴⁴ more...

Aliases & Descriptions:

synovitis 6 30 8 32 43 synovitis (disorder) 6

synovitis nos 6

Diseases related to synovitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 912)

id	Related Disease	Score	Top Affiliating Genes
1	arthritis	35.7	SERPINA1, MMP3, FGF1, IL17A, IL1A, IL1B
2	pigmented villonodular synovitis	34.9	PCNA, BGLAP, PANX2, LAPTM5, ATP6V1B2, MOAP1
3	villonodular synovitis	34.2	PCNA, BGLAP, CD68, MMP1, MMP9, IBSP
4	rheumatoid arthritis	33.6	IL1B, IL1RN, IL2, CCL21, HLA-DRB1, TNF
5	spondylarthropathy	31.0	S100A8, S100A9, B2M, CD163, TNF, CRP
6	giant cell tumor	30.5	BGLAP, MMP9, TNFRSF11B, TNFRSF8, TNFSF11, CSF1
7	ankylosing spondylitis	29.1	SERPINA1, BGLAP, CD40LG, MMP3, IL17A, IL1R1
8	reactive arthritis	27.9	SELE, MRAP, MMP1, MMP8, IL17A, IL18
9	spondylitis	23.3	SERPINA1, VEGFA, BGLAP, S100A8, MRAP, MPO
10	gonococcal synovitis	20.8	SELE, SERPINA1, VEGFA, VCAM1, S100A8, S100A9
11	osteoarthritis	20.6	SERPINA1, VEGFA, VCAM1, BGLAP, BCL2, S100A8
12	psoriasis	19.2	LRIG3, PCNA, SELE, SERPINA1, VEGFA, VCAM1
13	osteoporosis, postmenopausal	14.3	BGLAP, IL1RN, IL7, IBSP, TNFRSF11B, TNFSF11
14	joint disorders	14.2	MMP3, IL1R1, IL1RN, IL6, TNF, TNFRSF11B
15	osteopetrosis	14.2	BGLAP, ATP6V1B2, IL7, TNF, TNFRSF11B, TNFSF11
16	multicentric reticulohistiocytosis	14.2	CD68, TNF, TNFRSF11B, TNFSF11, CSF1
17	chronic infantile neurological cutaneous articular syndrome	14.2	IL18, IL1B, IL1R1, IL1RN, CASP1, TNFRSF1A
18	aggressive periodontitis	14.1	ITGB2, MMP1, MMP8, IL1A, HLA-B
19	muckle-wells syndrome	14.1	IL1B, IL1R1, IL8, CASP1, TNFRSF1A, CRP
20	periodic fever	14.1	IL1B, IL1R1, IL1RN, TNF, TNFRSF1A, TNFRSF1B
21	adult-onset still's disease	14.1	IL18, IL1R1, IL6, CRP, CSF1
22	paratyphoid fever	14.1	IL1A, IL1B, IL1R1, CASP1, TNF, TNFRSF1A
23	wells syndrome	14.1	IL1B, IL1R1, IL8, CASP1, TNFRSF1A, CRP
24	chst3-related skeletal dysplasia	14.1	MMP13, PTHLH, COMP, COL2A1, ACAN, STAT1
25	acute pyelonephritis	14.1	MMP9, IL1A, IL1R1, IL6, IL7, IL8
26	relapsing-remitting multiple sclerosis	14.1	MMP9, IL18, IL1RN, CCL5, ICAM1, SPP1
27	aneurysm disease	14.0	SERPINA1, MMP1, MMP9, IL1B, TIMP1, CX3CR1
28	hypercalciuria	14.0	BGLAP, B2M, MIP, IL1B, IL6, TNF
29	malignant ovarian cyst	14.0	MMP1, MMP13, MMP8, PRSS2
30	refractive error	14.0	MMP1, MMP13, MMP2, MMP3, MMP8, MMP9
31	renal osteodystrophy	14.0	BGLAP, B2M, IL6, TNFRSF11B, TNFSF11, ACP5
32	melioidosis	14.0	IL15, IL18, IL1B, IL6, CRP, TLR2
33	secondary syphilis	14.0	BGLAP, B2M, CCL4, IBSP, TNFRSF11B, TNFSF10
34	cinca syndrome	14.0	IL18, IL1B, IL1R1, CASP1
35	conjunctivochalasis	14.0	MMP1, MMP2, MMP3, MMP9, IL6, IL8
36	familial cold autoinflammatory syndrome	14.0	IL1B, IL1R1, CASP1, TNFRSF1A
37	t-cell large granular lymphocyte leukemia	14.0	IL15, IL18, IL6, IL8, TNF
38	behcet's disease	14.0	SELE, IL18, IL8, HLA-B, TNF, TNFRSF1B
39	stachybotrys chartarum	14.0	IL18, IL1A, IL1B, CCL4, CSF1
40	monoclonal gammopathy of undetermined significance	14.0	VCAM1, B2M, CD40LG, IL1B, IL6, ICAM1
41	cerebral malaria	14.0	SELE, VCAM1, IL1A, IL1B, IL1R1, IL1RN
42	pulpitis	14.0	CD163, MMP1, IL1A, IL8, TNF, TIMP1
43	schnitzler syndrome	14.0	CD40LG, IL18, IL1A, IL1R1, IL1RN, TNF
44	lymphocytic vasculitis	14.0	SH2D1A, SELE, VCAM1, ICAM1, TNF
45	bacterial meningitis	14.0	MMP8, IL1B, IL8, CCL4, CRP, TLR2
46	pyoderma gangrenosum	14.0	CD40LG, CD55, ITGB2, MMP1, IL1R1, IL6
47	pyoderma	14.0	CD40LG, CD55, ITGB2, MMP1, IL1R1, IL6
48	funisitis	13.9	S100A8, IL1B, IL6, IL8, CRP
49	psoriatic arthritis	13.9	IL1B, IL1RN, IL6, TNF, LTA
50	gaucher's disease	13.9	BGLAP, CD163, IL18, IL1R1, IL6, CCL4

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to synovitis:

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FMA organs/tissues related to synovitis:

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MGI Mouse Phenotypes related to synovitis:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.7	LTB, COL2A1, PLA2G4A, TRD@
2	craniofacial phenotype	MP:0005382	10.0	CSF1, ACAN, PDGFRB, COL2A1, PTPN11, CASP9
3	liver/biliary system phenotype	MP:0005370	9.8	TRD@, AKT1, F9, GPI, IL6, IL2
4	endocrine/exocrine gland phenotype	MP:0005379	9.6	IL2RB, IL2, CD40LG, XDH, UGDH, AQP1
5	limbs/digits/tail phenotype	MP:0005371	9.3	ITGB1, MMP13, MMP9, MDM2, FAS, IBSP
6	other phenotype	MP:0005395	9.1	TLR2, PLA2G4A, SPP1, PTGS1, PTGS2, TNFRSF1A
7	hematopoietic system phenotype	MP:0005397	8.9	BCL2, LIG1, PCNA, SH2D1A, LAPTM5, CALCR
8	nervous system phenotype	MP:0003631	8.7	TNFRSF1A, CD4, MYC, CD47, ITGB1, MMP2
9	embryogenesis phenotype	MP:0005380	8.6	CASP9, TNFRSF1A, PTK2, PTPN11, CTNNB1, COL2A1
10	renal/urinary system phenotype	MP:0005367	8.6	GADD45B, AQP1, ITGB1, CD55, BCL2, HSPA5
11	no phenotypic analysis	MP:0003012	8.5	F7, PTGS2, PTK2, PTPN11, CTNNB1, NTS
12	immune system phenotype	MP:0005387	8.3	ACP5, ACAN, LTB, PDGFRB, COL2A1, COMP
13	normal phenotype	MP:0002873	8.0	CALCR, AKT1, PTPN11, COMP, COL2A1, ACAN
14	mortality/aging	MP:0010768	7.6	PHB2, CASP7, HSPA5, ALOX15, F7, F9
15	integument phenotype	MP:0010771	7.4	PTGS1, TNFSF11, TNFRSF1B, TNFRSF1A, TRD@, HSPA5
16	skeleton phenotype	MP:0005390	7.4	PRG4, STAT1, THBS1, ACP5, ACAN, COL2A1
17	digestive/alimentary phenotype	MP:0005381	7.2	MYC, VEGFA, BCL2, CX3CR1, STAT1, TGFB1
18	adipose tissue phenotype	MP:0005375	7.2	TNFRSF1B, PTGS2, PTHLH, PTPN11, NTS, PDGFRB
19	behavior/neurological phenotype	MP:0005386	7.0	ADIPOQ, SLC1A1, CSF1R, CX3CR1, PRG4, STAT1
20	reproductive system phenotype	MP:0005389	6.9	MMP9, ITGB1, B2M, VEGFA, FGF2, ADIPOQ
21	muscle phenotype	MP:0005369	5.7	ITGB1, CD55, CD47, MPO, XDH, BCL2
22	vision/eye phenotype	MP:0005391	5.4	SLC1A1, CSF1, CX3CR1, TNFRSF1B, TNFRSF1A, TNF
23	growth/size phenotype	MP:0005378	5.4	ADIPOQ, CSF1R, CX3CR1, STAT1, THBS1, TICAM1
24	tumorigenesis	MP:0002006	4.8	FAS, ATM, B2M, BCL2, LIG1, MYC
25	cardiovascular system phenotype	MP:0005385	3.3	TNFRSF11B, GPI, CCL2, MAPK7, MAPK8, ANTXR1
26	homeostasis/metabolism phenotype	MP:0005376	2.9	STAT1, PF4, PLA2G4A, CRP, NTS, CTNNB1
27	cellular phenotype	MP:0005384	2.0	GADD45B, ADIPOQ, FAS, MMP13, ITGB2, ITGB1

Articles related to synovitis:

(show top 50)    (show all 115)

id	Title	Authors	Year	Affiliating Genes
1	Interleukin 34 expression is associated with synoviti s severity in rheumatoid arthritis patients. (22039170)	Chemel M.... Heymann D.	2012	IL34
2	Expression of Toll-like receptors and their signaling pathways in rheumatoid synovitis. (21324962)	Tamaki Y.... Takagi M.	2011	TIRAP, TICAM1
3	Overexpression of SPACIA1/SAAL1, a newly identified g ene that is involved in synoviocyte proliferation, accelerates the progression of synovitis in mice and humans. (22127701)	Sato T.... Nakajima T.	2011	SAAL1
4	Expression of aquaporin 1 (AQP1) in human synovitis. (20149606)	Mobasheri A.... Shakibaei M.	2010	AQP1, MIP
5	Gadd45beta deficiency in rheumatoid arthritis: enhanc ed synovitis through JNK signaling. (19877043)	Svensson C.I.... Firestein G.S.	2009	MMP3, MAPK8, MMP13
6	Immunohistological features of hip synovitis in ankylosing spondylitis with advanced hip involvement. (19165649)	Chen W.S.... Chou C.T.	2009	MMP3, CD68
7	Association between histopathologic type II synovitis and increased amounts of pyridinoline in synovial tissue samples in rheumatoid arthritis (18369645)	Wernicke D.... Hein G.	2008	COL2A1
8	Serum levels of matrix metalloproteinase 3 (stromelysin 1) for monitoring synovitis in rheumatoid arthritis. (17425385)	Kobayashi A.... Okada Y.	2007	MMP3
9	High expression level of bone degrading proteins as a possible inducer of osteolytic features in pigmented villonodular synovitis. (17601661)	Geldyyev A.... Berger I.	2007	SPP1, TNFRSF11B, TNFSF11
10	Synovial angiostatic non-ELR CXC chemokines in inflammatory arthritides: does CXCL4 designate chronicity of synovitis? (17265155)	Erdem H.... Sengul A.	2007	PF4, CXCL9
11	Pathogenesis of haemophilic synovitis: experimental studies on blood-induced joint damage. (17822515)	Valentino L.A.... Hoots W.K.	2007	TNFSF10
12	Changes in MMP-2 and -9 activity and MMP-8 reactivity after amphotericin B induced synovitis and treatment with bufexamac. (16901276)	Marttinen P.H.... Tulamo R.M.	2006	MMP2, MMP8, MMP9
13	Synovial proinflammatory cytokines and their correlation with matrix metalloproteinase-3 expression in BehAset's disease. Does interleukin-1beta play a major role in BehAset's synovitis? (16205926)	Pay S.... Dinc A.	2006	MMP3, TNF, IL1B
14	Role of osteopontin in amplification and perpetuation of rheumatoid synovitis. (15761492)	Xu G.... Zhang J.Z.	2005	SPP1
15	Rheumatoid and psoriatic knee synovitis: clinical, grey scale, and power Doppler ultrasound assessment of the response to etanercept. (15567814)	Fiocco U.... Rubaltelli L.	2005	TNF
16	Involvement of neurotrophins and their receptors in spondyloarthritis synovitis: relation to inflammation and response to treatment. (15817657)	Rihl M.... Baeten D.	2005	NTS
17	Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue. (16192646)	Stenman M.... Konttinen Y.T.	2005	MMP8, MMP9, SERPINA1
18	Excitatory amino acid transporters expressed by synov ial fibroblasts in rats with collagen-induced arthritis. (16242118)	Hinoi E.... Yoneda Y.	2005	SLC1A1
19	Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitis. (15186320)	Cook P.W.... Pittelkow M.R.	2004	AREG
20	Pathobiology of hemophilic synovitis I: overexpression of mdm2 oncogene. (15172967)	Hakobyan N.... Valentino L.A.	2004	MDM2
21	Anti-apoptogenic function of TGFbeta1 for human synov ial cells: TGFbeta1 protects cultured synovial cells from mitochondrial perturb ation induced by several apoptogenic stimuli. (14672900)	Kawakami A.... Eguchi K.	2004	TGFB1, CASP3, CASP9
22	Association of CD163+ macrophages and local production of soluble CD163 with decreased lymphocyte activation in spondylarthropathy synovitis. (15146432)	Baeten D.... De Keyser F.	2004	CD163
23	Participation of cyclooxygenase-1 in prostaglandin E2 release from synovitis tissue in primary osteoarthritis in vitro. (15262246)	Knorth H.... Willburger R.E.	2004	PTGS1, PTGS2
24	Interleukin-6, soluble interleukin-2 receptor and soluble interleukin-6 receptor in the sera of patients with different histological patterns of rheumatoid synovitis. (12673891)	Klimiuk P.A.... Chwiecko J.	2003	IL6, IL2RB
25	New strategies to control inflammatory synovitis: interleukin 15 and beyond. (14532150)	McInnes I.B.... Liew F.Y.	2003	IL15
26	Synoviocyte-mediated expansion of inflammatory T cells in rheumatoid synovitis is dependent on CD47-thrombospondin 1 interaction. (12902472)	Vallejo A.N.... Goronzy J.J.	2003	THBS1, FTL, CD47
27	Number of active joints, not diagnosis, is the primary determinant of function and performance in early synovitis. (14969053)	Gerber L.H.... El-Gabalawy H.	2003	CRP
28	Rheumatoid hand joint synovitis: gray-scale and power Doppler US quantifications following anti-tumor necrosis factor-alpha treatmen t: pilot study. (12970463)	Ribbens C.... Malaise M.G.	2003	TNF
29	Interleukin-1-induced glenohumeral synovitis and shoulder pain in rotator cuff diseases. (12472254)	Gotoh M.... Fukuda H.	2002	IL1B, IL1R1
30	Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment. (11796404)	Ribbens C.... Malaise M.G.	2002	MMP3, CRP
31	Soluble adhesion molecules (ICAM-1, VCAM-1, and E-selectin) and vascular endothelial growth factor (VEGF) in patients with distinct variants of rheumatoid synovitis. (12176805)	Klimiuk P.A.... Chwiecko J.	2002	ICAM1, VEGFA, SELE
32	Relationships between pain-related mediators and both synovitis and joint pain in patients with internal derangements and osteoarthritis of the temporomandibular joint. (12324788)	Nishimura M.... Miyamaru M.	2002	KNG1
33	Innate response cytokines in inflammatory synovitis: a role for interleukin-15. (11791467)	McInnes I.B.... Leung B.P.	2001	IL15
34	Serum cartilage oligomeric matrix protein reflects the presence of clinically diagnosed synovitis in patients with knee osteoarthritis. (11597173)	Vilim V.... Pavelka K.	2001	COMP
35	Lymphoid neogenesis in rheumatoid synovitis. (11441118)	Takemura S.... Weyand C.M.	2001	CXCL13, LTB
36	Methotrexate inhibits rheumatoid synovitis by inducin g apoptosis. (11508582)	Nakazawa F.... Kimura T.	2001	DNTT
37	Radiolabelled interleukin-1 receptor antagonist for detection of synovitis in patients with rheumatoid arthritis. (10952741)	Barrera P.... Corstens F.H.	2000	IL1R1, IL1RN
38	Antiinflammatory effect of tepoxalin: blood and synov ial tissue studied in patients with knee arthrosis. (9703407)	Willburger R.E.... Peskar B.A.	1998	ALOX5
39	Heparan sulfate proteoglycan on endothelium efficiently induces integrin-mediated T cell adhesion by immobilizing chemokines in patients with rheumatoid synovitis. (9704634)	Tanaka Y.... Eto S.	1998	CCL4
40	Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction. (9807705)	O'Keefe R.J.... Hicks D.G.	1998	MMP9
41	Treatment of rheumatoid synovitis with anti-reshaping human interleukin-6 receptor monoclonal antibody: use of rheumatoid arthritis tissue implants in the SCID mouse model. (9811057)	Matsuno H.... Yoshizaki K.	1998	MMP1, ACP5
42	Effect of synovitis and corticosteroids on transcription of cartilage matrix proteins. (9706207)	MacLeod J.N.... Todhunter R.J.	1998	ACAN, MATN1
43	Vascular turnover during carrageenan synovitis in the rat. (9881951)	Walsh D.A.... Claxson A.	1998	VEGFA
44	Giant cells in pigmented villo nodular synovitis express an osteoclast phenotype. (9306944)	Neale S.D.... Athanasou N.A.	1997	ACP5
45	Effects of rapamycin on apoptosis of rheumatoid synov ial cells. (9158086)	Migita K.... Nagataki S.	1997	BCL2, FAS
46	The role of VCAM-1 molecule in the pathogenesis of rheumatoid synovitis. (9183648)	Matsuyama T.... Kitani A.	1996	VCAM1, UGDH
47	Sustained and distinctive patterns of gene activation in synovial fibroblasts and whole synovial tissue obtained from inflammatory synovitis. (8091128)	Ritchlin C.... Winchester R.	1994	IL6, CSF1R, TIMP1
48	T cell receptor delta diversity of freshly isolated T lymphocytes in rheumatoid synovitis. (1825059)	Sioud M.... Natvig J.B.	1991	TRD@
49	Elevation of interleukin-8 (IL-8) levels in joint fluids of patients with rheumatoid arthritis and the induction by IL-8 of leukocyte infiltration and synovitis in rabbit joints. (1932367)	Endo H.... Matsushima K.	1991	IL8
50	Role of cytokines in inflammatory synovitis. The coordinate regulation of intercellular adhesion molecule 1 and HLA class I and class II antigens in rheumatoid synovial fibroblasts. (1701992)	Chin J.E.... Sanders M.E.	1990	ICAM1

Genes related to synovitis according to GeneCards:

(show top 50)    (show all 150)

id	Symbol	Description	Score	GeneCards Section Context
1	CASP1	caspase 1, apoptosis-related cysteine peptidase	11.1	Summaries
2	CASP7	caspase 7, apoptosis-related cysteine peptidase	11.1	Summaries
3	CASP10	caspase 10, apoptosis-related cysteine peptidase	11.1	Summaries
4	CASP9	caspase 9, apoptosis-related cysteine peptidase	11.1	Summaries, Publications
5	CD68	CD68 molecule	11.0	Publications
6	CASP4	caspase 4, apoptosis-related cysteine peptidase	11.0	Summaries
7	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
8	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	11.0	Publications
9	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
10	ACP5	acid phosphatase 5, tartrate resistant	11.0	Publications
11	IBSP	integrin-binding sialoprotein	11.0	Publications
12	PVR	poliovirus receptor	11.0
13	PTHLH	parathyroid hormone-like hormone	11.0	Publications
14	SPP1	secreted phosphoprotein 1	11.0	Publications
15	HLA-B	major histocompatibility complex, class I, B	11.0	Publications
16	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
17	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
18	CSF1	colony stimulating factor 1 (macrophage)	11.0
19	PCNA	proliferating cell nuclear antigen	11.0	Publications
20	LTB	lymphotoxin beta (TNF superfamily, member 3)	11.0	Publications
21	MATN1	matrilin 1, cartilage matrix protein	11.0	Publications
22	TRD@	T cell receptor delta locus	11.0	Publications
23	PRG4	proteoglycan 4	11.0	Publications
24	COMP	cartilage oligomeric matrix protein	11.0	Publications
25	CD163	CD163 molecule	11.0	Publications
26	MIP	major intrinsic protein of lens fiber	11.0	Publications
27	COL2A1	collagen, type II, alpha 1	11.0	Publications
28	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0	Publications
29	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications
30	MMP11	matrix metallopeptidase 11 (stromelysin 3)	11.0
31	ACAN	aggrecan	11.0	Publications
32	AQP1	aquaporin 1 (Colton blood group)	11.0	Publications
33	CSF1R	colony stimulating factor 1 receptor	11.0	Publications
34	CD69	CD69 molecule	11.0	Publications
35	GPI	glucose-6-phosphate isomerase	11.0	Publications
36	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
37	HMGB1	high mobility group box 1	11.0	Publications
38	IL15	interleukin 15	11.0	Publications
39	IL1R1	interleukin 1 receptor, type I	11.0	Publications
40	CX3CR1	chemokine (C-X3-C motif) receptor 1	11.0
41	PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	11.0	Publications
42	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	11.0
43	IL17A	interleukin 17A	11.0
44	IL7	interleukin 7	11.0
45	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
46	ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	11.0	Publications
47	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
48	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
49	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	11.0	Publications
50	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	11.0

Pathways related to synovitis according to GeneDecks:

(show top 50)    (show all 196)

id	Pathway	Score	Top Affiliating Genes
1	Activation of Matrix Metalloproteinases38	10.5	MMP1, MMP11, MMP13, MMP2, MMP3, MMP8
2	Malaria20	10.0	SELE, VCAM1, CD40LG, ITGB2, IL18, IL1B
3	TNF Superfamily Pathway36	9.8	JUN, MAPK8, CASP7, CASP10, CASP3, CASP4
4	Pertussis20	9.7	JUN, ITGB1, ITGB2, IL1A, IL1B, IL6
5	RAR-Gamma-RXR-Alpha Degradation36	9.7	IL15, IL16, IL2, IL7, CCL4, CCL21
6	UPA-UPAR Pathway36	9.7	JUN, ITGB1, ITGB2, MMP1, MMP11, MMP13
7	Transendothelial Migration of Leukocytes36	9.4	VCAM1, ITGB1, ITGB2, MMP1, MMP11, MMP13
8	Osteoclast differentiation20	9.3	JUN, IL1A, IL1B, IL1R1, MAPK8, CALCR
9	Influenza A20	9.3	JUN, IL18, IL1A, IL1B, IL6, IL8
10	Toll-like receptor signaling pathway20	9.3	JUN, IL1B, IL6, IL8, MAPK8, CCL4
11	IL-6 Pathway36	9.2	IL16, IL18, IL4, IL7, IL8, MAPK7
12	NF-KappaB Family Pathway36	9.1	AREG, FGF1, FGF2, IL1A, IL1B, IL1R1
13	Apoptosis and survival Lymphotoxin-beta receptor signaling10	9.0	VCAM1, JUN, IL2, IL8, MAPK8, CCL21
14	Apoptosis and survival_Lymphotoxin-beta receptor signaling41	9.0	VCAM1, JUN, IL2, IL8, MAPK8, CCL21
15	14-3-3 Induced Apoptosis36	8.9	BCL2, JUN, IL1A, IL1B, IL1R1, MAPK8
16	Rheumatoid arthritis20	8.9	VEGFA, ATP6V1B2, JUN, ITGB2, MMP1, MMP3
17	Regulation of eIF4 and p70S6K36	8.7	CD4, ITGB1, ITGB2, FGF1, IL15, IL16
18	NF-KappaB (p50-p65) Pathway36	8.6	AREG, FGF1, FGF2, IL1A, IL1B, IL1R1
19	Endothelin-1 Signaling Pathway36	8.5	MYC, IL16, IL18, IL1A, IL1B, IL2
20	Chagas disease (American trypanosomiasis)20	8.4	JUN, IL1B, IL6, FAS, MAPK8, CCL2
21	Tuberculosis20	8.3	BCL2, ITGB2, IL18, IL1A, IL1B, IL6
22	PGC1Alpha Pathway36	8.2	BCL2, CD4, IL15, IL16, IL18, IL1A
23	ERK Signaling36	8.2	MYC, ITGB1, ITGB2, AREG, IL16, IL18
24	ILK Signaling36	8.2	JUN, ITGB1, ITGB2, AREG, FGF1, FGF2
25	Akt Signaling36	8.0	CD4, ITGB2, FGF1, IL15, IL16, IL18
26	DHA Signaling36	7.9	BCL2, AREG, FGF1, FGF2, IL1B, IL2
27	NFAT Signaling and Lymphocyte Interactions36	7.9	BCL2, CD4, IL15, IL16, IL1A, IL2
28	PEDF Induced Signaling36	7.7	BCL2, IL15, IL16, IL18, IL1A, IL1B
29	Pancreatic Adenocarcinoma36	7.6	BCL2, MMP1, MMP11, MMP13, MMP2, MMP3
30	SOCS Pathway36	7.5	BCL2, CD4, FGF1, FGF2, IL15, IL16
31	Cellular Apoptosis Pathway36	7.4	BCL2, ATM, AREG, FGF1, FGF2, IL2
32	MIF Mediated Glucocorticoid Regulation36	7.4	BCL2, IL15, IL16, IL18, IL1A, IL1B
33	JNK Pathway36	7.4	BCL2, JUN, CD4, AREG, FGF1, FGF2
34	Cytokine-cytokine receptor interaction20	7.4	VEGFA, CD40LG, IL15, IL17A, IL18, IL1A
35	all-trans-Retinoic Acid Signaling in Brain36	7.2	BCL2, IL15, IL16, IL18, IL1A, IL1B
36	STAT3 Pathway36	7.2	MYC, BCL2, CD4, IL15, IL16, IL18
37	MAPK Signaling36	7.2	MYC, BCL2, JUN, ITGB1, ITGB2, AREG
38	Glucocorticoid Receptor Signaling36	7.0	BCL2, JUN, CD4, IL15, IL16, IL18
39	p53 Mediated Apoptosis36	6.7	BCL2, ATM, AREG, FGF1, FGF2, IL2
40	MIF Regulation of Innate Immune Cells36	6.7	BCL2, JUN, IL15, IL16, IL18, IL1A
41	Pathways in cancer20	6.5	VEGFA, MYC, BCL2, JUN, ITGB1, MMP1
42	p38 Signaling36	6.4	BCL2, CD4, AREG, FGF1, FGF2, IL15
43	Tec Kinases Signaling36	6.4	BCL2, CD4, ITGB1, ITGB2, AREG, FGF1
44	PAK Pathway36	6.3	BCL2, AREG, FGF1, FGF2, IL15, IL16
45	MAPK Family Pathway36	6.2	BCL2, JUN, CD4, AREG, FGF1, FGF2
46	TGF-Beta Pathway36	6.1	BCL2, JUN, CD4, AREG, FGF1, FGF2
47	Rho Family GTPases36	6.0	BCL2, JUN, ITGB1, ITGB2, AREG, FGF1
48	Antioxidant Action of Vitamin-C36	5.8	BCL2, JUN, CD4, AREG, FGF1, FGF2
49	JAK-STAT Pathway36	5.8	MYC, BCL2, JUN, CD4, AREG, FGF1
50	Molecular Mechanisms of Cancer36	5.6	MYC, BCL2, ATM, JUN, CD4, ITGB1

Compounds related to synovitis according to GeneDecks:

(show top 50)    (show all 467)

id	Compound	Score	Top Affiliating Genes
1	procollagen32	10.5	PCNA, BGLAP, MMP1, MMP13, MMP2, MMP3
2	n-formylmethionyl-leucylphenylalanine32	10.3	MPO, CD55, ITGB2, FPR2, IL1A, ICAM1
3	etanercept32 9 9	12.3	MMP1, MMP3, IL15, IL17A, IL18, IL1B
4	1,25 dihydroxy vitamin d332	10.2	MYC, BGLAP, S100A9, CD4, IL18, IL1A
5	phorbol32	9.9	MYC, JUN, CD69, CD4, ITGB2, MMP1
6	p00232	9.9	MMP13, MMP3, MMP8, MMP9, IL15, IL17A
7	polymyxin b32	9.7	SELE, VCAM1, ITGB2, IL1A, IL1B, IL1RN
8	zoledronic acid32	9.7	BGLAP, MMP9, IL2, IBSP, TNFRSF11B, TNFSF10
9	12-o-tetradecanoylphorbol 13-acetate32	9.6	MYC, CD4, ITGB1, ITGB2, MMP11, MMP13
10	aspartate32	9.6	PCNA, B2M, CD40LG, CD55, ITGB2, MMP2
11	fibrinogen32	9.5	SELE, SERPINA1, VCAM1, S100A9, CD40LG, CD47
12	polyinosinic-polycytidylic acid32	9.4	SELE, VCAM1, IL15, IL18, IL2, IL4
13	epinephrine32 9 18 9	12.4	SELE, CD69, MMP1, MMP2, MMP9, AREG
14	n acetylcysteine32	9.3	PCNA, SELE, VCAM1, ATM, MMP1, MMP2
15	heparin32 9 18 9	12.3	SERPINA1, BGLAP, MPO, CD69, CD4, CD55
16	fluticasone propionate32 42 9 9	12.2	SELE, VCAM1, BGLAP, MPO, MMP9, IL16
17	methotrexate32 34 42 9 9	13.2	PCNA, SELE, S100A8, S100A9, CD69, MMP1
18	h2o232	9.2	SERPINA1, BGLAP, S100A9, XDH, MPO, FTL
19	neopterin32	9.1	B2M, CD4, CD40LG, IL18, IL1A, IL1B
20	pentoxifylline32 9 9	11.1	VCAM1, MPO, ITGB2, MMP1, MMP2, IL18
21	vitamin a32 9 18 9	12.1	SERPINA1, MYC, B2M, FAS, IGHE, ALDH2
22	mg 13232 42	10.0	PCNA, MYC, JUN, IL1A, IL1B, IL8
23	rapamycin32 42	9.9	VEGFA, IL1R1, IL2, IL2RB, MDM2, MAPK8
24	rituximab32 34 9 9	11.9	BCL2, CD40LG, CD55, IL15, IL1R1, IL2
25	methacholine32 9 9	10.9	MPO, IL17A, IL2RB, IL4, IL8, CCL5
26	okt332	8.8	SELE, VCAM1, CD40LG, ITGB2, IL15, IL2
27	doxorubicin32 34 9 9	11.8	SELE, B2M, ATM, CD40LG, MMP1, IL18
28	glutamate32	8.7	PCNA, UGDH, S100A8, CD4, CD47, ITGB2
29	prednisolone32 9 9	10.7	VCAM1, MYC, BGLAP, MPO, ITGB2, MMP1
30	testosterone32 9 18 9	11.7	PCNA, SELE, VCAM1, BGLAP, B2M, CD40LG
31	atp32	8.6	LIG1, S100A9, ATM, CD55, ITGB1, ITGB2
32	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	8.6	PCNA, MYC, BCL2, MMP2, MMP9, IL1A
33	tarc32	8.5	CD4, IL18, IL1A, IL4, IL8, CCL4
34	diphenyleneiodonium32	8.5	VEGFA, VCAM1, XDH, MPO, JUN, IL1B
35	gm-csf32	8.5	VEGFA, IL15, IL18, IL1A, IL1B, IL2
36	tacrolimus32 34 9 9	11.4	PCNA, MYC, CD69, MIP, IL15, IL16
37	cysteine32	8.3	PCNA, SERPINA1, BGLAP, S100A8, XDH, CD4
38	camptothecin32 42 9 9	11.0	PCNA, MYC, BCL2, ATM, JUN, MDM2
39	ag 147832	8.0	JUN, MMP2, MMP9, AREG, IL8, FAS
40	cyclosporin a32 42	8.2	MYC, BGLAP, B2M, JUN, CD69, CD55
41	pdtc32	7.1	SELE, VCAM1, BCL2, XDH, JUN, MMP1
42	etoposide32 42 9 9	10.0	PCNA, SELE, MYC, LIG1, BCL2, ATM
43	paclitaxel32 34 9 9	9.9	PCNA, VEGFA, MYC, BCL2, ITGB2, MMP1
44	resveratrol32 9 18 9	9.9	PCNA, VEGFA, BCL2, XDH, JUN, MMP2
45	triptolide32	6.8	VEGFA, BCL2, JUN, MMP3, IL1B, IL2
46	alanine32	6.5	PCNA, SELE, VCAM1, MYC, LIG1, BGLAP
47	herbimycin a32 42	6.5	SELE, VCAM1, MYC, JUN, CD69, CD4
48	cisplatin32 34 9 9	7.7	PCNA, VEGFA, MYC, LIG1, BGLAP, BCL2
49	phosphatidylinositol32	4.7	VCAM1, MYC, BCL2, ATM, JUN, CD69
50	dexamethasone32 42 34 9 9	6.9	PCNA, VEGFA, VCAM1, MYC, BGLAP, BCL2

Cellular components related to synovitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	proteinaceous extracellular matrix	GO:005578	10.0	FGF1, MATN1, TNFRSF11B, COMP, ACAN, TGFB1
2	cell surface	GO:009986	9.8	TNFRSF1A, ELANE, TLR2, TIMP2, TGFB1, PVR
3	platelet alpha granule lumen	GO:031093	9.6	TGFB1, THBS1, TIMP1, PF4, VEGFA, SERPINA1
4	integral to plasma membrane	GO:005887	9.1	TNFSF10, TNFRSF1A, TNF, HLA-DRB1, TNFSF11, PDGFRB
5	external side of plasma membrane	GO:009897	8.7	ICAM1, HLA-DRB1, TNF, TLR2, THBS1, CXCL12
6	plasma membrane	GO:005886	7.3	TNFRSF1B, TNFRSF1A, TNF, HLA-DRB1, HLA-B, AKT1
7	extracellular region	GO:005576	7.0	FGF2, IL15, IL18, IL1A, IL1B, IL1R1
8	extracellular space	GO:005615	6.5	ADIPOQ, SELE, IL15, IL16, IL17A, IL18

Biological processes related to synovitis according to GeneDecks:

(show top 50)    (show all 85)

id	Name	GO ID	Score	Top Affiliating Genes
1	collagen catabolic process	GO:030574	10.9	MMP13, MMP11, MMP2, MMP1, MMP3, MMP8
2	extracellular matrix disassembly	GO:022617	10.8	MMP1, MMP11, MMP13, MMP2, MMP3, MMP8
3	extracellular matrix organization	GO:030198	10.6	PRSS2, TIMP2, TNFRSF11B, TNF, IBSP, COL2A1
4	leukocyte cell-cell adhesion	GO:007159	10.5	VCAM1, CD40LG, SELE, ITGB1, ICAM1, ITGB2
5	chronic inflammatory response	GO:002544	10.5	THBS1, CXCL13, CCL5, S100A9, S100A8, VCAM1
6	defense response to Gram-positive bacterium	GO:050830	10.5	ACP5, IL6, TNF, PLA2G2A, LTA, TLR2
7	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.4	TNF, CASP1, ADIPOQ, TNFRSF1A, TNFSF11, TICAM1
8	proteolysis	GO:006508	10.4	MMP11, ELANE, PRSS2, CASP1, CASP4, CASP3
9	cellular response to mechanical stimulus	GO:071260	10.3	TNFRSF8, CASP1, TNFRSF1A, FAS, IL18, ITGB1
10	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.3	ICAM1, TGFB1, TIRAP, TICAM1, TLR2, TNFSF11
11	lipopolysaccharide-mediated signaling pathway	GO:031663	10.1	TICAM1, TLR2, IL18, IL1B, CCL2, CCL5
12	positive regulation of inflammatory response	GO:050729	10.1	IL15, CD47, IL18, TNFRSF1A, PLA2G2A, TLR2
13	lymph node development	GO:048535	10.1	CXCL13, IL15, LTB, TGFB1, LTA
14	cytokine-mediated signaling pathway	GO:019221	10.1	CCL2, ICAM1, HLA-B, HLA-DRB1, TNFRSF1A, TNFSF11
15	positive regulation of angiogenesis	GO:045766	10.1	MMP9, FGF1, IL1A, IL1B, AQP1, CCL5
16	positive regulation of fever generation	GO:031622	10.0	TNF, CCL5, PTGS2, IL1B, PLA2G4A
17	positive regulation of nitric oxide biosynthetic process	GO:045429	10.0	IL1B, ICAM1, AKT1, TNF, TICAM1, TLR2
18	cell-cell signaling	GO:007267	9.8	IL2, IL1B, IL18, IL17A, IL15, ITGB2
19	response to vitamin D	GO:033280	9.7	IL1B, PTGS2, SPP1, PLA2G4A, TGFB1, BGLAP
20	positive regulation of cell migration	GO:030335	9.7	CCL5, PDGFRB, THBS1, CSF1R, CSF1, PTK2
21	positive regulation of protein phosphorylation	GO:001934	9.6	TGFB1, IL1B, CSF1R, ADIPOQ, PTK2, TNF
22	humoral immune response	GO:006959	9.6	BCL2, IL6, SH2D1A, LTA, IL7, CCL2
23	induction of apoptosis	GO:006917	9.5	LTA, TLR2, STAT1, THBS1, TNFSF10, TNF
24	cellular response to organic cyclic compound	GO:071407	9.5	IL1B, IL18, TGFB1, CCL2, CCL5, TNF
25	positive regulation of smooth muscle cell proliferation	GO:048661	9.4	STAT1, ELANE, PDGFRB, JUN, PTGS2, IL6
26	positive regulation of neuron apoptotic process	GO:043525	9.4	CASP3, TNF, IL18, JUN, ATM, CASP9
27	cell adhesion	GO:007155	9.4	ACAN, FPR2, BGLAP, CD4, CD47, CCL4
28	response to glucocorticoid stimulus	GO:051384	9.3	IL1RN, HMGB1, PLA2G4A, FAS, BGLAP, IL1B
29	innate immune response	GO:045087	9.2	IL34, CD4, IL1R1, BCL2, CD55, CSF1R
30	response to lipopolysaccharide	GO:032496	9.2	TIRAP, ELANE, MMP9, IL1A, FAS, CASP1
31	aging	GO:007568	9.2	PTGS1, JUN, TGFB1, TIMP1, PLA2G4A, CASP7
32	cellular response to organic substance	GO:071310	9.1	TIMP2, CASP1, CASP3, IL1B, CD68, BCL2
33	platelet activation	GO:030168	9.1	SERPINA1, VEGFA, CD40LG, IL6, HSPA5, AKT1
34	blood coagulation	GO:007596	9.1	KNG1, F7, F9, MMP1, THBS1, VEGFA
35	response to radiation	GO:009314	9.0	JUN, CXCL12, BCL2, TGFB1, IL18, TNFSF11
36	chemotaxis	GO:006935	9.0	CXCL9, CXCL12, CX3CR1, CCL5, CCL2, CCL4
37	positive regulation of apoptotic process	GO:043065	8.9	PTGS2, TNFSF10, TNFRSF8, TNF, FAS, CTNNB1
38	inflammatory response	GO:006954	8.9	CRP, IL6, IL34, IL1B, IL1A, IL18
39	response to ethanol	GO:045471	8.8	BCL2, S100A8, BGLAP, ADIPOQ, TNFRSF1A, ICAM1
40	immune response	GO:006955	8.6	CXCL9, CXCL13, CXCL12, PRG4, THBS1, TLR2
41	positive regulation of cell proliferation	GO:008284	8.6	PTHLH, MDM2, PTK2, PLA2G4A, PDGFRB, TIMP1
42	positive regulation of B cell proliferation	GO:030890	8.4	TICAM1, BCL2, TIRAP, IL4, IL2, CD40LG
43	signal transduction	GO:007165	8.4	CXCL9, CSF1R, CD4, ATM, TLR2, FGF1
44	response to hypoxia	GO:001666	8.1	CASP1, TNF, TNFRSF1A, LTA, THBS1, TGFB1
45	anti-apoptosis	GO:006916	8.1	BCL2, AKT1, IL1A, CD40LG, MPO, FAS
46	apoptotic process	GO:006915	8.0	GADD45B, CASP9, AKT1, HMGB1, TNF, TNFRSF11B
47	response to cytokine stimulus	GO:034097	8.0	JUN, SERPINA1, BCL2, ACP5, STAT1, TIMP1
48	negative regulation of apoptotic process	GO:043066	7.3	PTK2, TNF, CASP3, HSPA5, MAPK7, MAPK8
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.2	IL6, MAPK7, AKT1, TNFSF11, STAT1, HMGB1
50	response to drug	GO:042493	6.8	MYC, BGLAP, BCL2, B2M, JUN, ITGB1

Molecular functions related to synovitis according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	tumor necrosis factor receptor binding	GO:005164	10.1	STAT1, LTB, LTA, TNFSF11, TNFSF10, TNF
2	calcium ion binding	GO:005509	10.0	F7, HSPA5, PLA2G4A, PLA2G2A, COMP, THBS1
3	transmembrane signaling receptor activity	GO:004888	10.0	TLR2, TNFRSF8, ICAM1, ANTXR1, IL1R1, CD4
4	chemokine activity	GO:008009	9.8	CXCL9, CXCL13, CXCL12, PF4, CCL5, CCL21
5	protease binding	GO:002020	9.4	ELANE, TNFRSF1A, TNF, IL1R1, ITGB1, BCL2
6	heparin binding	GO:008201	8.9	PF4, ELANE, THBS1, CXCL13, KNG1, COMP
7	growth factor activity	GO:008083	8.3	IL7, GPI, TGFB1, CXCL12, CSF1, IL6
8	cytokine activity	GO:005125	8.2	ADIPOQ, GPI, HMGB1, TNF, TNFRSF11B, TNFSF10
9	protein binding	GO:005515	3.5	HMGB1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, PTK2