MCID: SYN007
MIFTS: 51

Synovitis malady

Rare diseases category

Summaries for Synovitis

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Disease Ontology:9 A connective tissue disease that results in inflammation located in synovial membrane that lines a synovial joint which causes pain and swelling.

MalaCards based summary: Synovitis is related to pigmented villonodular synovitis and giant cell tumor. An important gene associated with Synovitis is MMP1 (matrix metallopeptidase 1 (interstitial collagenase)), and among its related pathways are Macrophage Differentiation and Growth Inhibition by METS and Interleukin-11 Signaling Pathway. The compounds pyridinoline and ibandronate have been mentioned in the context of this disorder. Affiliated tissues include synovial membrane, bone and t cells, and related mouse phenotypes are endocrine/exocrine gland and craniofacial.

Wikipedia:63 Synovitis is the medical term for inflammation of the synovial membrane. This membrane lines joints... more...

Aliases & Classifications for Synovitis

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Synovitis, Aliases & Descriptions:

Name: Synovitis 9 41 11 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:2703
NCIt38 C50766
MeSH33 D013585
ICD1025 M65.9

Related Diseases for Synovitis

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Diseases related to Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 255)
idRelated DiseaseScoreTop Affiliating Genes
1pigmented villonodular synovitis32.0CSF1R, CSF1, PDGFRB
2giant cell tumor31.1CSF1R, CSF1, TNFSF11
3osteomyelitis31.0IBSP, TNFSF11, ACP5
4psoriatic arthritis30.9TNFSF11, TNFRSF11B, MMP1
5arthropathy30.7TNFRSF11B, TNFSF11, MMP1
6osteonecrosis30.6BGLAP
7arthritis30.3CSF1, CSF1R, TNFRSF11B, ACP5, MMP1, MMP9
8sarcoma30.3PDGFRB, CSF1R, CSF1
9osteopetrosis, autosomal dominant 230.2TNFSF11, BGLAP
10myelodysplastic syndrome30.1CSF1, CSF1R, PDGFRB
11rheumatic disease30.0BGLAP, TNFRSF11B, TNFSF11
12rheumatoid arthritis29.8MMP9, MMP1, ACP5, TNFSF11, IBSP, BGLAP
13osteoarthritis28.9SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B, PTHLH
14secondary syphilis28.7SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B, PTHLH
15adenocarcinoma28.5IBSP, MMP9, PTHLH, PDGFRB, SPP1, TNFSF11
16melanoma28.3PDGFRB, MMP1, CSF1R, MMP9, CSF1, TNFRSF11B
17villonodular synovitis11.2
18acne10.7
19hyperostosis10.7
20sapho syndrome10.6
21cherubism10.5TNFSF11
22periapical granuloma10.5TNFSF11
23camurati-engelmann disease10.4BGLAP
24osteolysis, familial expansile10.4TNFRSF11B, TNFSF11
25paget disease, juvenile10.4TNFSF11, TNFRSF11B
26hyperostosis, endosteal10.4TNFSF11, TNFRSF11B
27fibromatosis10.4PDGFRB
28polymyalgia rheumatica10.4
29thalassemia, hispanic gamma-delta-beta10.3TNFSF11, TNFRSF11B
30tenosynovial giant cell tumor10.3
31acute myelomonocytic leukemia10.3CSF1R, CSF1
32malignant histiocytosis10.3CSF1, CSF1R
33gingivitis10.3TNFRSF11B, TNFSF11, MMP1
34hemarthrosis10.3
35endometrial stromal sarcoma10.3PDGFRB, CSF1
36ameloblastoma10.3TNFRSF11B, IBSP, TNFSF11
37fibrous dysplasia10.2IBSP, BGLAP
38septic arthritis10.2
39gonococcal synovitis10.2
40endotheliitis10.2
41pseudohypoparathyroidism, type ib10.2BGLAP, PTHLH
42dentin dysplasia10.2SPP1, IBSP
43pseudohypoparathyroidism10.2PTHLH, BGLAP
44tuberculosis10.2
45nephrolithiasis10.2IBSP, SPP1
46hyperphosphatemia10.2TNFRSF11B, SPP1
47dentinogenesis imperfecta10.2IBSP, SPP1
48lung cancer10.2MMP9
49spondyloarthropathy 110.2TNFSF11, BGLAP, TNFRSF11B
50periodontal disease10.2TNFSF11, MMP1

Graphical network of the top 20 diseases related to Synovitis:



Diseases related to synovitis

Symptoms for Synovitis

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Drugs & Therapeutics for Synovitis

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Drug clinical trials:

Search ClinicalTrials for Synovitis

Search NIH Clinical Center for Synovitis

Genetic Tests for Synovitis

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Anatomical Context for Synovitis

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MalaCards organs/tissues related to Synovitis:

31
Bone, T cells, Bone marrow, Endothelial, Neutrophil, Skin, Testes, Spinal cord, Lung, Breast, Prostate, Monocytes, B cells

FMA organs/tissues related to Synovitis:

14
Synovial membrane

Animal Models for Synovitis or affiliated genes

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Publications for Synovitis

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Articles related to Synovitis:

(show top 50)    (show all 1102)
idTitleAuthorsYear
1
Computed Tomography and Magnetic Resonance Manifestations of Spinal Pigmented Villonodular Synovitis. (25836023)
2015
2
Transtrochanteric rotational osteotomy combined with intra-articular procedures for pigmented villonodular synovitis of the hip. (24687213)
2014
3
Unusual cases of pigmented villonodular synovitis after arthroplasty. (24955198)
2014
4
Patients with rheumatoid arthritis in clinical remission and ultrasound-defined active synovitis exhibit higher disease activity and increased serum levels of angiogenic biomarkers. (24398122)
2014
5
Transient synovitis, septic hip, and Legg-CalvAc-Perthes disease: an approach to the correct diagnosis. (25439014)
2014
6
Comparison of arthroscopic, radioactive and combined synovectomy in the treatment of chronic non-specific knee synovitis. (25196268)
2014
7
In patients with early rheumatoid arthritis, the new ACR/EULAR definition of remission identifies patients with persistent absence of functional disability and suppression of ultrasonographic synovitis. (23060009)
2013
8
Synovitis and bone inflammation in early rheumatoid arthritis: high-resolution multi-pinhole SPECT versus MRI. (23255070)
2013
9
Low-dose external beam radiotherapy as a postoperative treatment for patients with diffuse pigmented villonodular synovitis of the knee: 4 recurrences in 23 patients followed for mean 9 years. (22489888)
2012
10
Hip joint pigmented villonodular synovitis in a young girl: a case report. (22433958)
2012
11
Pigmented villonodular synovitis of the ankle presenting as a persisting ankle effusion. (22764668)
2012
12
Chondroblastoma of the femoral neck as a cause of hip synovitis. (21685802)
2012
13
Case 181: synovitis acne pustulosis hyperostosis osteitis (SAPHO) syndrome. (22517965)
2012
14
The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis). (22733940)
2012
15
One step open synovectomy without adjuvant therapy for diffuse pigmented villonodular synovitis of the knee in a soccer player. (23738243)
2011
16
Utility of ultrasound joint counts in the prediction of rheumatoid arthritis in patients with very early synovitis. (21115552)
2011
17
Correlation between synovitis detected on enhanced-magnetic resonance imaging and a histological analysis with a patient-oriented outcome measure for Japanese patients with end-stage knee osteoarthritis receiving joint replacement surgery. (20567866)
2010
18
Clinical synovitis in a particular joint is associated with progression of erosions and joint space narrowing in that same joint, but not in patients initially treated with infliximab. (20610442)
2010
19
MRI of macrophages in infectious knee synovitis. (20489072)
2010
20
Metallosis and Metal-Induced Synovitis Following Total Knee Arthroplasty: Review of Radiographic and CT Findings. (22470753)
2010
21
Quantification of synovitis in rheumatoid arthritis: do we really need quantitative measurement of contrast-enhanced ultrasound? (19410408)
2009
22
Semiquantitative assessment of synovitis in osteoarthritis on non contrast-enhanced MRI. (19070515)
2009
23
Tuberculous synovitis of the hip joint diagnosed by FDG PET-CT. (19542947)
2009
24
Lyme arthritis presenting as transient synovitis of the hip. (18519920)
2008
25
Synovial lymphoid neogenetic factors in BehAset's synovitis: do they play a role in self-limiting and subacute course of arthritis? (17949547)
2007
26
Radial and ulnar neuropathy due to pigmented villonodular synovitis of the elbow. (17126239)
2006
27
Pigmented villonodular synovitis. (16311109)
2006
28
Role of osteopontin in amplification and perpetuation of rheumatoid synovitis. (15761492)
2005
29
Involvement of matrix metalloproteinases and their inhibitors in peripheral synovitis and down-regulation by tumor necrosis factor alpha blockade in spondylarthropathy. (15457463)
2004
30
Pigmented villonodular synovitis: a disease in evolution. (15290750)
2004
31
New strategies to control inflammatory synovitis: interleukin 15 and beyond. (14532150)
2003
32
Chronic synovitis and HLA B27 in patients with severe haemophilia. (12648975)
2003
33
c-myc proto-oncogene expression in hemophilic synovitis: in vitro studies of the effects of iron and ceramide. (12130502)
2002
34
Tuberculosis of the hip as the presenting sign of HIV and simulating pigmented villonodular synovitis. (12107577)
2002
35
Villonodular synovitis of the temporomandibular joint: case report. (11732040)
2001
36
Intraarticular osteoid osteoma associated with synovitis: a possible role of cyclooxygenase-2 expression by osteoblasts in the nidus. (11048802)
2000
37
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
38
Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome presenting as a primary calvarial lesion. Case report and review of the literature. (11014551)
2000
39
Lipoma induced by pigmented villonodular synovitis of the ankle. (10359296)
1999
40
An unusual case of pigmented villonodular synovitis of the spine: benign aggressive and/or malignant? (10371292)
1999
41
Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction. (9807705)
1998
42
Articular pigmented villonodular synovitis of the MP joint of the hand. (8543887)
1995
43
Diagnostic features of diffuse pigmented villonodular synovitis of the knee. (8118978)
1994
44
Expression of decay-accelerating factor is reduced on hyperplastic synovial lining cells in rheumatoid synovitis. (1706235)
1991
45
Low levels of interleukin-4 and high levels of transforming growth factor beta in rheumatoid synovitis. (2390123)
1990
46
Role of cytokines in inflammatory synovitis. The coordinate regulation of intercellular adhesion molecule 1 and HLA class I and class II antigens in rheumatoid synovial fibroblasts. (1701992)
1990
47
Case report 578: Pigmented villonodular synovitis of the shoulder. (2321043)
1990
48
Pigmented villonodular synovitis of the hip--association with osteochondromatosis. (3440329)
1987
49
Pigmented villonodular synovitis of the temporomandibular joint: a case report. (10994414)
1982
50
Arthrographic findings in Legg-CalvAc-Perthes disease and transient synovitis of the hip. (670266)
1978

Variations for Synovitis

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Expression for genes affiliated with Synovitis

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Search GEO for disease gene expression data for Synovitis.

Pathways for genes affiliated with Synovitis

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Pathways related to Synovitis according to GeneCards Suite gene sharing:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7CSF1, CSF1R
29.6IBSP, BGLAP
3
Show member pathways
RANKL/RANK Signaling Pathway36
Apoptosis and survival APRIL and BAFF signaling58
9.5ACP5, TNFRSF11B, TNFSF11
49.4MMP9, MMP1
59.4MMP9, MMP1
69.2PDGFRB, CSF1R, CSF1
79.2CSF1, CSF1R, PDGFRB
89.2ACP5, MMP1, CSF1, TNFSF11
99.1CSF1R, CSF1, SPP1
10
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.1TNFRSF11B, TNFSF11, MMP9
119.0SPP1, MMP9
129.0MMP9, SPP1
139.0TNFRSF11B, IBSP, TNFSF11, PDGFRB
14
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
9.0IBSP, PDGFRB, SPP1
15
Show member pathways
8.9TNFSF11, CSF1, PDGFRB, CSF1R
16
Show member pathways
8.9CSF1, PDGFRB, CSF1R, TNFSF11
178.9TNFRSF11B, SPP1, TNFSF11, ACP5
188.9MMP1, BGLAP, MMP9
19
Show member pathways
Signaling Pathways in Glioblastoma36
8.9MMP9, MMP1, PDGFRB
208.8CSF1R, ACP5, TNFRSF11B, TNFSF11, CSF1
218.7TNFRSF11B, TNFSF11, BGLAP, SPP1
22
Show member pathways
8.6CSF1, PDGFRB, CSF1R, TNFRSF11B, TNFSF11
238.6PTHLH, SPP1, MMP9
248.5SPP1, BGLAP, MMP9
258.5CSF1R, PDGFRB, MMP9, MMP1
26
Show member pathways
8.5PDGFRB, MMP1, MMP9, CSF1R
27
Show member pathways
8.4MMP1, MMP9, SPP1, IBSP
28
Show member pathways
8.3CSF1, SPP1, PDGFRB, CSF1R, TNFSF11
298.3PDGFRB, CSF1, CSF1R, IBSP, SPP1
308.2SPP1, TNFSF11, BGLAP, IBSP, PTHLH

Compounds for genes affiliated with Synovitis

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Compounds related to Synovitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 183)
idCompoundScoreTop Affiliating Genes
1pyridinoline4310.6TNFRSF11B
2ibandronate43 1210.3IBSP, TNFRSF11B, TNFSF11, BGLAP
3vitamin k2439.3BGLAP, TNFRSF11B, CSF1, TNFSF11
4pamidronate43 49 1211.0BGLAP, TNFSF11, TNFRSF11B, PTHLH, MMP1
5deoxypyridinoline439.0TNFRSF11B, ACP5, BGLAP, IBSP, TNFSF11
6alendronate43 49 1211.0BGLAP, TNFSF11, TNFRSF11B, MMP1, PTHLH
7tartrate438.9TNFSF11, CSF1, ACP5, PTHLH, BGLAP
8infliximab43 49 1210.7TNFSF11, MMP1, TNFRSF11B, BGLAP, SPP1
9clodronate43 49 1210.7BGLAP, ACP5, MMP1, PTHLH, TNFRSF11B, TNFSF11
10celecoxib43 59 28 49 24 1213.6TNFSF11, CSF1, MMP1, MMP9, TNFRSF11B
11geranylgeranyl pyrophosphate438.5TNFRSF11B, MMP1, TNFSF11, MMP9
12titanium438.4TNFSF11, ACP5, IBSP, BGLAP, SPP1, TNFRSF11B
13ns 39843 599.4MMP1, TNFSF11, BGLAP, TNFRSF11B, MMP9, CSF1
1425-hydroxyvitamin d438.3PTHLH, TNFRSF11B, TNFSF11, SPP1, BGLAP, ACP5
15phosphorus438.3SPP1, BGLAP, TNFSF11, TNFRSF11B, PTHLH, ACP5
16indomethacin43 28 59 1211.3TNFRSF11B, CSF1, MMP1, PTHLH, TNFSF11, SPP1
17prostaglandin438.3CSF1, TNFSF11, MMP1, TNFRSF11B, MMP9, PTHLH
18rantes438.2TNFRSF11B, CSF1, ACP5, MMP9, TNFSF11, MMP1
19estradiol43 24 1210.2TNFRSF11B, TNFSF11, MMP1, PTHLH, ACP5, IBSP
20ascorbic acid43 249.2CSF1, SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B
21hydroxyapatite438.0BGLAP, IBSP, TNFSF11, TNFRSF11B, PTHLH, ACP5
22zoledronic acid437.9IBSP, TNFSF11, TNFRSF11B, PTHLH, MMP9, MMP1
23hydroxyproline43 24 129.8BGLAP, IBSP, TNFRSF11B, PTHLH, MMP9, MMP1
24pd 98,059437.7SPP1, IBSP, TNFSF11, MMP9, MMP1, CSF1R
25sb 20358043 598.7MMP9, BGLAP, SPP1, MMP1, TNFSF11, TNFRSF11B
26genistein43 28 59 2 24 1212.6TNFSF11, SPP1, PDGFRB, CSF1, TNFRSF11B, MMP9
27heparin43 28 24 1210.6SPP1, IBSP, CSF1, ACP5, PTHLH, TNFRSF11B
28tgf beta1437.6MMP1, TNFRSF11B, PTHLH, SPP1, PDGFRB, CSF1
29h2o2437.5PDGFRB, BGLAP, CSF1, SPP1, ACP5, TNFSF11
30cyclosporin a43 28 599.5MMP1, BGLAP, ACP5, TNFRSF11B, SPP1, TNFSF11
31progesterone43 28 59 24 1211.5SPP1, CSF1R, MMP1, CSF1, PDGFRB, TNFRSF11B
32matrigel437.5IBSP, PDGFRB, PTHLH, SPP1, MMP9, MMP1
33procollagen437.4SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B, MMP9
341,25 dihydroxy vitamin d3437.3PTHLH, CSF1R, CSF1, ACP5, TNFRSF11B, SPP1
35calcitriol43 59 24 1210.2TNFSF11, BGLAP, SPP1, TNFRSF11B, PTHLH, MMP1
36vitamin d437.1SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B, PTHLH
37cycloheximide437.0IBSP, SPP1, CSF1, CSF1R, MMP1, MMP9
38phosphatidylinositol436.8IBSP, PTHLH, TNFRSF11B, TNFSF11, MMP9, CSF1R
39testosterone43 59 24 129.7PDGFRB, MMP1, PTHLH, TNFRSF11B, TNFSF11, BGLAP
40creatinine436.6MMP1, ACP5, CSF1, SPP1, BGLAP, IBSP
41retinoic acid43 247.6SPP1, BGLAP, TNFRSF11B, PTHLH, MMP9, MMP1
42tyrosine436.3PDGFRB, CSF1, CSF1R, ACP5, MMP9, PTHLH
43dexamethasone43 49 28 129.2CSF1, CSF1R, ACP5, MMP1, MMP9, PTHLH
44pge2436.2ACP5, SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B
45calcium43 49 24 129.1PTHLH, SPP1, BGLAP, IBSP, PDGFRB, ACP5
46cysteine436.1PDGFRB, CSF1, CSF1R, ACP5, MMP1, MMP9
47vegf436.0BGLAP, SPP1, IBSP, TNFSF11, TNFRSF11B, PDGFRB
48serine436.0PTHLH, SPP1, BGLAP, TNFSF11, CSF1, CSF1R
49paraffin436.0IBSP, BGLAP, SPP1, TNFSF11, PTHLH, PDGFRB
50estrogen435.6BGLAP, SPP1, TNFSF11, IBSP, PDGFRB, CSF1

GO Terms for genes affiliated with Synovitis

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Cellular components related to Synovitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00055789.1MMP9, MMP1, TNFRSF11B
2membrane-bounded vesicleGO:00319889.0BGLAP, SPP1
3extracellular spaceGO:00056157.0TNFRSF11B, PTHLH, MMP9, CSF1, BGLAP, SPP1
4extracellular regionGO:00055766.9MMP1, SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B

Biological processes related to Synovitis according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1osteoclast proliferationGO:000215810.2CSF1, TNFSF11
2positive regulation of osteoclast differentiationGO:004567210.0CSF1, TNFSF11
3bone resorptionGO:004545310.0TNFSF11, ACP5
4regulation of bone resorptionGO:00451249.8BGLAP, CSF1R
5phosphatidylinositol metabolic processGO:00464889.8PDGFRB, CSF1R
6positive regulation of bone resorptionGO:00457809.8TNFSF11, SPP1
7osteoclast differentiationGO:00303169.8CSF1, CSF1R, TNFSF11
8osteoblast developmentGO:00020769.7PTHLH, BGLAP
9odontogenesisGO:00424769.7CSF1, BGLAP
10positive regulation of MAP kinase activityGO:00434069.7PDGFRB, TNFSF11
11biomineral tissue developmentGO:00312149.6IBSP, SPP1
12response to vitamin DGO:00332809.6SPP1, BGLAP
13cellular response to growth factor stimulusGO:00713639.5BGLAP, IBSP
14positive regulation of cell migrationGO:00303359.5PDGFRB, CSF1, CSF1R
15macrophage differentiationGO:00302259.3CSF1, CSF1R, MMP9
16extracellular matrix disassemblyGO:00226179.0MMP1, MMP9, SPP1
17ossificationGO:00015039.0CSF1, MMP9, TNFSF11, IBSP
18positive regulation of cell proliferationGO:00082849.0PTHLH, CSF1R, CSF1, PDGFRB
19embryo implantationGO:00075669.0MMP9, SPP1
20inflammatory responseGO:00069548.8CSF1, CSF1R, SPP1
21skeletal system developmentGO:00015018.7BGLAP, TNFRSF11B, PTHLH, MMP9
22extracellular matrix organizationGO:00301988.5SPP1, IBSP, TNFRSF11B, MMP9, MMP1

Molecular functions related to Synovitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.9CSF1, TNFRSF11B, TNFSF11, SPP1

Products for genes affiliated with Synovitis

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Sources for Synovitis

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3CDC
13ExPASy
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25ICD10
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28IUPHAR
29KEGG
33MeSH
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