MCID: SYN007
MIFTS: 59

Synovitis malady

Rare diseases category

Summaries for Synovitis

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A connective tissue disease that results in inflammation located in synovial membrane that lines a synovial joint which causes pain and swelling.

MalaCards: Synovitis, also known as synovitis nos, is related to pigmented villonodular synovitis and arthritis. An important gene associated with Synovitis is MMP1 (matrix metallopeptidase 1 (interstitial collagenase)), and among its related pathways are Macrophage Differentiation and Growth Inhibition by METS and Interleukin-11 Signaling Pathway. The compounds pyridinoline and ibandronate have been mentioned in the context of this disorder. Affiliated tissues include synovial membrane, bone and t cells, and related mouse phenotypes are endocrine/exocrine gland and craniofacial.

Wikipedia:66 Synovitis is the medical term for inflammation of the synovial membrane. This membrane lines joints... more...

Aliases & Classifications for Synovitis

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

synovitis 9 44 11 46 63
synovitis nos 9


External Ids:

Disease Ontology9 DOID:2703
MeSH36 D013585
NCIt41 C50766
ICD1026 M65.9

Related Diseases for Synovitis

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18GeneCards, 19GeneDecks
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Diseases in the Synovitis family:

Synovitis, Chronic

Diseases related to Synovitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 261)
idRelated DiseaseScoreTop Affiliating Genes
1pigmented villonodular synovitis31.8CSF1R, CSF1, PDGFRB
2arthritis31.1BGLAP, TNFSF11, TNFRSF11B, MMP9, MMP1, ACP5
3rheumatoid arthritis30.9SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B, MMP9
4giant cell tumor30.8TNFSF11, CSF1R, CSF1
5osteomyelitis30.7IBSP, TNFSF11, ACP5
6psoriatic arthritis30.6TNFSF11, TNFRSF11B, MMP1
7osteoarthritis30.4CSF1, CSF1R, ACP5, MMP1, MMP9, PTHLH
8arthropathy30.3MMP1, TNFRSF11B, TNFSF11
9sarcoma30.2CSF1R, CSF1, PDGFRB
10osteonecrosis30.1BGLAP
11osteopetrosis autosomal dominant type 229.9BGLAP, TNFSF11
12ankylosing spondylitis29.8BGLAP, TNFSF11, TNFRSF11B
13rheumatic disease29.8BGLAP, TNFSF11, TNFRSF11B
14myelodysplastic syndromes29.8PDGFRB, CSF1, CSF1R
15secondary syphilis29.5CSF1, ACP5, PTHLH, TNFRSF11B, TNFSF11, IBSP
16adenocarcinoma29.4SPP1, IBSP, TNFSF11, PTHLH, MMP9, CSF1R
17melanoma29.4SPP1, IBSP, TNFSF11, TNFRSF11B, MMP9, MMP1
18osteosarcoma29.2PDGFRB, CSF1, CSF1R, ACP5, MMP1, MMP9
19villonodular synovitis11.2
20acne10.6
21hyperostosis10.6
22sapho syndrome10.6
23polymyalgia rheumatica10.3
24tenosynovial giant cell tumor10.3
25hemarthrosis10.3
26endotheliitis10.2
27septic arthritis10.2
28gonococcal synovitis10.2
29neuropathy10.1
30tuberculosis10.1
31spondylarthropathy10.1
32synovial chondromatosis10.1
33cherubism10.1TNFSF11
34periapical granuloma10.1TNFSF11
35camurati-engelmann disease10.1BGLAP
36paget disease, juvenile10.1TNFSF11, TNFRSF11B
37polyostotic osteolytic dysplasia, hereditary expansile10.1TNFSF11, TNFRSF11B
38osteosclerosis10.1TNFSF11, TNFRSF11B
39fibromatosis10.1PDGFRB
40beta thalassemia10.1TNFSF11, TNFRSF11B
41acute myelomonocytic leukemia10.1CSF1, CSF1R
42reactive arthritis10.1
43carpal tunnel syndrome10.1
44blau syndrome10.1
45lipoma10.1
46malignant giant cell tumor10.1
47psoriasis10.1
48syphilis10.1
49eosinophilic fasciitis10.1
50talo-patello-scaphoid osteolysis, synovitis, and short fourth metacarpals10.1

Graphical network of the top 20 diseases related to Synovitis:



Diseases related to synovitis

Symptoms for Synovitis

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Drugs & Therapeutics for Synovitis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Synovitis

Search CenterWatch for Synovitis

Genetic Tests for Synovitis

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Anatomical Context for Synovitis

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Synovitis:

34
Bone, T cells, Endothelial, Bone marrow, B cells, Testes, Skin, Prostate, Breast, Monocytes, Lung, Spinal cord

FMA organs/tissues related to Synovitis:

15
Synovial membrane

Animal Models for Synovitis or affiliated genes

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38MGI
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Publications for Synovitis

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53PubMed
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Articles related to Synovitis:

(show top 50)    (show all 1025)
idTitleAuthorsYear
1
In patients with early rheumatoid arthritis, the new ACR/EULAR definition of remission identifies patients with persistent absence of functional disability and suppression of ultrasonographic synovitis. (23060009)
2013
2
Synovitis and bone inflammation in early rheumatoid arthritis: high-resolution multi-pinhole SPECT versus MRI. (23255070)
2013
3
Low-dose external beam radiotherapy as a postoperative treatment for patients with diffuse pigmented villonodular synovitis of the knee: 4 recurrences in 23 patients followed for mean 9 years. (22489888)
2012
4
Hip joint pigmented villonodular synovitis in a young girl: a case report. (22433958)
2012
5
Pigmented villonodular synovitis of the ankle presenting as a persisting ankle effusion. (22764668)
2012
6
Chondroblastoma of the femoral neck as a cause of hip synovitis. (21685802)
2012
7
Case 181: synovitis acne pustulosis hyperostosis osteitis (SAPHO) syndrome. (22517965)
2012
8
The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis). (22733940)
2012
9
One step open synovectomy without adjuvant therapy for diffuse pigmented villonodular synovitis of the knee in a soccer player. (23738243)
2011
10
Utility of ultrasound joint counts in the prediction of rheumatoid arthritis in patients with very early synovitis. (21115552)
2011
11
Correlation between synovitis detected on enhanced-magnetic resonance imaging and a histological analysis with a patient-oriented outcome measure for Japanese patients with end-stage knee osteoarthritis receiving joint replacement surgery. (20567866)
2010
12
Clinical synovitis in a particular joint is associated with progression of erosions and joint space narrowing in that same joint, but not in patients initially treated with infliximab. (20610442)
2010
13
MRI of macrophages in infectious knee synovitis. (20489072)
2010
14
Metallosis and Metal-Induced Synovitis Following Total Knee Arthroplasty: Review of Radiographic and CT Findings. (22470753)
2010
15
Protracted synovitis without systemic manifestations in familial Mediterranean fever (FMF). (20868584)
2010
16
Quantification of synovitis in rheumatoid arthritis: do we really need quantitative measurement of contrast-enhanced ultrasound? (19410408)
2009
17
Semiquantitative assessment of synovitis in osteoarthritis on non contrast-enhanced MRI. (19070515)
2009
18
Tuberculous synovitis of the hip joint diagnosed by FDG PET-CT. (19542947)
2009
19
Lyme arthritis presenting as transient synovitis of the hip. (18519920)
2008
20
Case report: subacute synovitis of the knee after a rose thorn injury: unusual clinical picture. (18773251)
2008
21
Synovial lymphoid neogenetic factors in BehAset's synovitis: do they play a role in self-limiting and subacute course of arthritis? (17949547)
2007
22
Radial and ulnar neuropathy due to pigmented villonodular synovitis of the elbow. (17126239)
2006
23
Pigmented villonodular synovitis. (16311109)
2006
24
Role of osteopontin in amplification and perpetuation of rheumatoid synovitis. (15761492)
2005
25
Involvement of matrix metalloproteinases and their inhibitors in peripheral synovitis and down-regulation by tumor necrosis factor alpha blockade in spondylarthropathy. (15457463)
2004
26
Pigmented villonodular synovitis: a disease in evolution. (15290750)
2004
27
New strategies to control inflammatory synovitis: interleukin 15 and beyond. (14532150)
2003
28
Chronic synovitis and HLA B27 in patients with severe haemophilia. (12648975)
2003
29
c-myc proto-oncogene expression in hemophilic synovitis: in vitro studies of the effects of iron and ceramide. (12130502)
2002
30
Tuberculosis of the hip as the presenting sign of HIV and simulating pigmented villonodular synovitis. (12107577)
2002
31
Villonodular synovitis of the temporomandibular joint: case report. (11732040)
2001
32
Intraarticular osteoid osteoma associated with synovitis: a possible role of cyclooxygenase-2 expression by osteoblasts in the nidus. (11048802)
2000
33
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
34
Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome presenting as a primary calvarial lesion. Case report and review of the literature. (11014551)
2000
35
Lipoma induced by pigmented villonodular synovitis of the ankle. (10359296)
1999
36
An unusual case of pigmented villonodular synovitis of the spine: benign aggressive and/or malignant? (10371292)
1999
37
Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction. (9807705)
1998
38
Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome: a brief review of a rare condition. (9588288)
1998
39
Diffuse pigmented villonodular synovitis of the knee associated with chronic ACL deficiency. (9606698)
1998
40
Articular pigmented villonodular synovitis of the MP joint of the hand. (8543887)
1995
41
Diagnostic features of diffuse pigmented villonodular synovitis of the knee. (8118978)
1994
42
Pigmented villonodular synovitis of the knee demonstrated on bone scan. Correlation with US, CT, and MRI. (1424384)
1992
43
Expression of decay-accelerating factor is reduced on hyperplastic synovial lining cells in rheumatoid synovitis. (1706235)
1991
44
Low levels of interleukin-4 and high levels of transforming growth factor beta in rheumatoid synovitis. (2390123)
1990
45
Role of cytokines in inflammatory synovitis. The coordinate regulation of intercellular adhesion molecule 1 and HLA class I and class II antigens in rheumatoid synovial fibroblasts. (1701992)
1990
46
Case report 578: Pigmented villonodular synovitis of the shoulder. (2321043)
1990
47
Pigmented villonodular synovitis in a vertebra. A case report. (2365726)
1990
48
Pigmented villonodular synovitis of the hip--association with osteochondromatosis. (3440329)
1987
49
Pigmented villonodular synovitis of the temporomandibular joint: a case report. (10994414)
1982
50
Arthrographic findings in Legg-CalvAc-Perthes disease and transient synovitis of the hip. (670266)
1978

Variations for Synovitis

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Expression for genes affiliated with Synovitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Synovitis

Search GEO for disease gene expression data for Synovitis.

Pathways for genes affiliated with Synovitis

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Sources:
51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG, 56Reactome
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Pathways related to Synovitis according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7CSF1R, CSF1
29.6IBSP, BGLAP
3
Show member pathways
RANKL/RANK Signaling Pathway39
Apoptosis and survival APRIL and BAFF signaling61
9.5ACP5, TNFRSF11B, TNFSF11
49.4MMP9, MMP1
59.4MMP9, MMP1
69.2PDGFRB, CSF1, CSF1R
79.2CSF1R, CSF1, PDGFRB
89.2TNFSF11, MMP1, ACP5, CSF1
99.1CSF1, CSF1R, SPP1
10
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
9.1MMP9, TNFRSF11B, TNFSF11
119.0MMP9, SPP1
129.0SPP1, MMP9
139.0IBSP, TNFSF11, TNFRSF11B, PDGFRB
14
Show member pathways
Integrin-mediated cell adhesion39
Focal Adhesion39
9.0PDGFRB, IBSP, SPP1
15
Show member pathways
8.9TNFSF11, CSF1R, CSF1, PDGFRB
16
Show member pathways
8.9TNFSF11, CSF1R, CSF1, PDGFRB
178.9ACP5, TNFRSF11B, TNFSF11, SPP1
188.9MMP1, MMP9, BGLAP
19
Show member pathways
Signaling Pathways in Glioblastoma39
8.9MMP9, MMP1, PDGFRB
208.8TNFSF11, TNFRSF11B, ACP5, CSF1R, CSF1
218.7TNFRSF11B, TNFSF11, BGLAP, SPP1
22
Show member pathways
8.6TNFSF11, TNFRSF11B, CSF1R, CSF1, PDGFRB
238.6MMP9, PTHLH, SPP1
248.5SPP1, BGLAP, MMP9
258.5MMP9, MMP1, CSF1R, PDGFRB
26
Show member pathways
8.5MMP9, MMP1, CSF1R, PDGFRB
27
Show member pathways
8.4SPP1, IBSP, MMP9, MMP1
28
Show member pathways
8.3PDGFRB, CSF1, CSF1R, TNFSF11, SPP1
298.3SPP1, IBSP, CSF1R, CSF1, PDGFRB
308.2PTHLH, TNFSF11, IBSP, BGLAP, SPP1

Compounds for genes affiliated with Synovitis

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46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Synovitis according to GeneCards/GeneDecks:

(show top 50)    (show all 183)
idCompoundScoreTop Affiliating Genes
1pyridinoline4610.6TNFRSF11B
2ibandronate46 1210.3IBSP, TNFRSF11B, TNFSF11, BGLAP
3vitamin k2469.3BGLAP, TNFRSF11B, CSF1, TNFSF11
4pamidronate46 52 1211.0BGLAP, TNFSF11, TNFRSF11B, PTHLH, MMP1
5deoxypyridinoline469.0TNFRSF11B, ACP5, BGLAP, IBSP, TNFSF11
6alendronate46 52 1211.0BGLAP, TNFSF11, TNFRSF11B, MMP1, PTHLH
7tartrate468.9TNFSF11, CSF1, ACP5, PTHLH, BGLAP
8infliximab46 52 1210.7TNFSF11, MMP1, TNFRSF11B, BGLAP, SPP1
9clodronate46 52 1210.7BGLAP, ACP5, MMP1, PTHLH, TNFRSF11B, TNFSF11
10celecoxib46 62 30 52 25 1213.6TNFSF11, CSF1, MMP1, MMP9, TNFRSF11B
11geranylgeranyl pyrophosphate468.5TNFRSF11B, MMP1, TNFSF11, MMP9
12titanium468.4TNFSF11, ACP5, IBSP, BGLAP, SPP1, TNFRSF11B
13ns 39846 629.4MMP1, TNFSF11, BGLAP, TNFRSF11B, MMP9, CSF1
1425-hydroxyvitamin d468.3PTHLH, TNFRSF11B, TNFSF11, SPP1, BGLAP, ACP5
15phosphorus468.3SPP1, BGLAP, TNFSF11, TNFRSF11B, PTHLH, ACP5
16indomethacin46 30 62 1211.3TNFRSF11B, CSF1, MMP1, PTHLH, TNFSF11, SPP1
17prostaglandin468.3CSF1, TNFSF11, MMP1, TNFRSF11B, MMP9, PTHLH
18rantes468.2TNFRSF11B, CSF1, ACP5, MMP9, TNFSF11, MMP1
19estradiol46 25 1210.2TNFRSF11B, TNFSF11, MMP1, PTHLH, ACP5, IBSP
20ascorbic acid46 259.2CSF1, SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B
21hydroxyapatite468.0BGLAP, IBSP, TNFSF11, TNFRSF11B, PTHLH, ACP5
22zoledronic acid467.9IBSP, TNFSF11, TNFRSF11B, PTHLH, MMP9, MMP1
23hydroxyproline46 25 129.8BGLAP, IBSP, TNFRSF11B, PTHLH, MMP9, MMP1
24pd 98,059467.7SPP1, IBSP, TNFSF11, MMP9, MMP1, CSF1R
25sb 20358046 628.7MMP9, BGLAP, SPP1, MMP1, TNFSF11, TNFRSF11B
26genistein46 30 62 3 25 1212.6TNFSF11, SPP1, PDGFRB, CSF1, TNFRSF11B, MMP9
27heparin46 30 25 1210.6SPP1, IBSP, CSF1, ACP5, PTHLH, TNFRSF11B
28tgf beta1467.6MMP1, TNFRSF11B, PTHLH, SPP1, PDGFRB, CSF1
29h2o2467.5PDGFRB, BGLAP, CSF1, SPP1, ACP5, TNFSF11
30cyclosporin a46 30 629.5MMP1, BGLAP, ACP5, TNFRSF11B, SPP1, TNFSF11
31progesterone46 30 62 25 1211.5SPP1, CSF1R, MMP1, CSF1, PDGFRB, TNFRSF11B
32matrigel467.5IBSP, PDGFRB, PTHLH, SPP1, MMP9, MMP1
33procollagen467.4SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B, MMP9
341,25 dihydroxy vitamin d3467.3PTHLH, CSF1R, CSF1, ACP5, TNFRSF11B, SPP1
35calcitriol46 62 25 1210.2TNFSF11, BGLAP, SPP1, TNFRSF11B, PTHLH, MMP1
36vitamin d467.1SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B, PTHLH
37cycloheximide467.0IBSP, SPP1, CSF1, CSF1R, MMP1, MMP9
38phosphatidylinositol466.8IBSP, PTHLH, TNFRSF11B, TNFSF11, MMP9, CSF1R
39testosterone46 62 25 129.7PDGFRB, MMP1, PTHLH, TNFRSF11B, TNFSF11, BGLAP
40creatinine466.6MMP1, ACP5, CSF1, SPP1, BGLAP, IBSP
41retinoic acid46 257.6SPP1, BGLAP, TNFRSF11B, PTHLH, MMP9, MMP1
42tyrosine466.3PDGFRB, CSF1, CSF1R, ACP5, MMP9, PTHLH
43dexamethasone46 52 30 129.2CSF1, CSF1R, ACP5, MMP1, MMP9, PTHLH
44pge2466.2ACP5, SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B
45calcium46 52 25 129.1PTHLH, SPP1, BGLAP, IBSP, PDGFRB, ACP5
46cysteine466.1PDGFRB, CSF1, CSF1R, ACP5, MMP1, MMP9
47vegf466.0BGLAP, SPP1, IBSP, TNFSF11, TNFRSF11B, PDGFRB
48serine466.0PTHLH, SPP1, BGLAP, TNFSF11, CSF1, CSF1R
49paraffin466.0IBSP, BGLAP, SPP1, TNFSF11, PTHLH, PDGFRB
50estrogen465.6BGLAP, SPP1, TNFSF11, IBSP, PDGFRB, CSF1

GO Terms for genes affiliated with Synovitis

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17Gene Ontology
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Cellular components related to Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.1MMP9, MMP1, TNFRSF11B
2membrane-bounded vesicleGO:0319889.0BGLAP, SPP1
3extracellular spaceGO:0056157.0TNFRSF11B, PTHLH, MMP9, CSF1, BGLAP, SPP1
4extracellular regionGO:0055766.9MMP1, SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B

Biological processes related to Synovitis according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1osteoclast proliferationGO:00215810.2CSF1, TNFSF11
2positive regulation of osteoclast differentiationGO:04567210.0CSF1, TNFSF11
3bone resorptionGO:04545310.0TNFSF11, ACP5
4regulation of bone resorptionGO:0451249.8BGLAP, CSF1R
5phosphatidylinositol metabolic processGO:0464889.8PDGFRB, CSF1R
6positive regulation of bone resorptionGO:0457809.8TNFSF11, SPP1
7osteoclast differentiationGO:0303169.8CSF1, CSF1R, TNFSF11
8osteoblast developmentGO:0020769.7PTHLH, BGLAP
9odontogenesisGO:0424769.7CSF1, BGLAP
10positive regulation of MAP kinase activityGO:0434069.7PDGFRB, TNFSF11
11biomineral tissue developmentGO:0312149.6IBSP, SPP1
12response to vitamin DGO:0332809.6SPP1, BGLAP
13cellular response to growth factor stimulusGO:0713639.5BGLAP, IBSP
14positive regulation of cell migrationGO:0303359.5PDGFRB, CSF1, CSF1R
15macrophage differentiationGO:0302259.3CSF1, CSF1R, MMP9
16extracellular matrix disassemblyGO:0226179.0MMP1, MMP9, SPP1
17ossificationGO:0015039.0CSF1, MMP9, TNFSF11, IBSP
18positive regulation of cell proliferationGO:0082849.0PTHLH, CSF1R, CSF1, PDGFRB
19embryo implantationGO:0075669.0MMP9, SPP1
20inflammatory responseGO:0069548.8CSF1, CSF1R, SPP1
21skeletal system developmentGO:0015018.7BGLAP, TNFRSF11B, PTHLH, MMP9
22extracellular matrix organizationGO:0301988.5SPP1, IBSP, TNFRSF11B, MMP9, MMP1

Molecular functions related to Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.9CSF1, TNFRSF11B, TNFSF11, SPP1

Products for genes affiliated with Synovitis

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  • Antibodies
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Sources for Synovitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet