MCID: SYN007
MIFTS: 59

Synovitis malady

Summaries for Synovitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A connective tissue disease that results in inflammation located in synovial membrane that lines a synovial joint which causes pain and swelling.

MalaCards: Synovitis, also known as synovitis nos, is related to pigmented villonodular synovitis and arthritis. An important gene associated with Synovitis is MMP1 (matrix metallopeptidase 1 (interstitial collagenase)), and among its related pathways are Osteoclast differentiation and PI3K-Akt signaling pathway. The compounds paraffin and creatinine have been mentioned in the context of this disorder. Affiliated tissues include synovial membrane, bone and t cells, and related mouse phenotypes are immune system and skeleton.

Wikipedia:63 Synovitis is the medical term for inflammation of the synovial membrane. This membrane lines joints... more...

Aliases & Classifications for Synovitis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Related Diseases for Synovitis

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17GeneCards, 18GeneDecks
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Diseases in the Synovitis family:

Synovitis, Chronic

Diseases related to Synovitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 267)
idRelated DiseaseScoreTop Affiliating Genes
1pigmented villonodular synovitis31.7PDGFRB, LAPTM5, MOAP1, CSF1R, CSF1, ATP6V1B2
2arthritis31.3ACP5, MMP9, MMP1, TNFRSF11B, TNFSF11, CSF1
3rheumatoid arthritis31.2BGLAP, SPP1, IBSP, CSF1, TNFRSF11B, CD68
4hyperostosis30.9BGLAP
5osteoarthritis30.8PTHLH, BGLAP, SPP1, MMP9, MMP1, CD68
6giant cell tumor30.7TNFSF11, TNFRSF11B, CSF1, MMP9, BGLAP
7osteomyelitis30.5IBSP, TNFSF11, ACP5
8psoriatic arthritis30.4MMP1, TNFRSF11B, TNFSF11
9sarcoma30.2CSF1, CSF1R, PDGFRB
10arthropathy30.2MMP1, TNFRSF11B, TNFSF11
11osteonecrosis29.9BGLAP
12osteosarcoma29.7MMP9, SPP1, BGLAP, IBSP, PDGFRB, CSF1R
13melanoma29.7CSF1, PDGFRB, TNFSF11, TNFRSF11B, CD68, SPP1
14secondary syphilis29.7SPP1, PTHLH, ACP5, TNFSF11, TNFRSF11B, CSF1
15adenocarcinoma29.7SPP1, PTHLH, TNFSF11, IBSP, PDGFRB, MMP9
16leukemia29.7PDGFRB, CSF1R, CSF1, CALCR, ACP5
17diabetes mellitus29.7BGLAP, MMP9
18squamous cell carcinoma29.7PTHLH, CSF1R, MMP1, SPP1, MMP9, IBSP
19multicentric reticulohistiocytosis29.7CD68
20ankylosing spondylitis29.7BGLAP, TNFRSF11B, TNFSF11
21osteopetrosis autosomal dominant type 229.7TNFSF11, BGLAP
22villonodular synovitis11.1
23acne10.6
24sapho syndrome10.5
25polymyalgia rheumatica10.3
26tenosynovial giant cell tumor10.3
27hemarthrosis10.2
28transient arthritis10.2
29gonococcal synovitis10.1
30septic arthritis10.1
31pigmentation disease10.1
32reactive arthritis10.1
33malignant giant cell tumor10.1
34neuropathy10.1
35tuberculosis10.1
36carpal tunnel syndrome10.0
37lipoma10.0
38psoriasis10.0
39syphilis10.0
40talo-patello-scaphoid osteolysis, synovitis, and short fourth metacarpals10.0
41breast cancer10.0CSF1, IBSP, TNFRSF11B, MMP1, CALCR, TNFSF11
42myeloma10.0SPP1, IBSP, ACP5, TNFSF11, CALCR, PTHLH
43osteoporosis10.0BGLAP, CALCR, CSF1, SPP1, TNFSF11, PTHLH
44bone carcinoma10.0SPP1, PTHLH, MMP9, TNFRSF11B, TNFSF11, PDGFRB
45atherosclerosis10.0TNFRSF11B, PDGFRB, IBSP, CD68, MMP9, MMP1
46chronic kidney failure10.0SPP1, PTHLH, ACP5, TNFRSF11B, IBSP, BGLAP
47osteoporosis, postmenopausal10.0ACP5, BGLAP, IBSP, TNFSF11, TNFRSF11B, PTHLH
48hypercalcemia10.0TNFRSF11B, BGLAP, CALCR, CSF1, PTHLH, TNFSF11
49hyperparathyroidism10.0ACP5, TNFRSF11B, TNFSF11, BGLAP, PTHLH
50kidney cancer10.0PDGFRB, CSF1R, CSF1, MMP9, PTHLH, SPP1

Graphical network of the top 20 diseases related to Synovitis:



Diseases related to synovitis

Clinical Features for Synovitis

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Drugs & Therapeutics for Synovitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Synovitis

Drug clinical trials:

Search ClinicalTrials for Synovitis

Search NIH Clinical Center for Synovitis

Search CenterWatch for Synovitis

Genetic Tests for Synovitis

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Anatomical Context for Synovitis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Synovitis:

32
Bone, T cells, Endothelial, Bone marrow, B cells, Testes, Skin, Prostate, Breast, Monocytes, Lung, Spinal cord

FMA organs/tissues related to Synovitis:

14
Synovial membrane

Animal Models for Synovitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Synovitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.1PVR, CALCR, PDGFRB, CSF1R, CSF1, TNFSF11
2MP:000539011.0SPP1, IBSP, CALCR, CSF1R, CSF1, TNFSF11
3MP:000539710.9CALCR, PDGFRB, CSF1R, CSF1, TNFSF11, TNFRSF11B
4MP:000537610.8CSF1R, PDGFRB, CALCR, PVR, CSF1, TNFSF11
5MP:000538210.7PTHLH, TNFRSF11B, TNFSF11, CSF1, CSF1R, PDGFRB
6MP:000537110.7CSF1R, CSF1, ACP5
7MP:001077110.3CSF1R, TNFSF11, MMP9, SPP1

Publications for Synovitis

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50PubMed
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Articles related to Synovitis:

(show top 50)    (show all 1036)
idTitleAuthorsYear
1
Simultaneous bilateral posterior interosseous nerve palsy caused by rheumatoid synovitis of the elbows. (23456322)
2013
2
A comparative study on the anti-inflammatory effects of single oral doses of naproxen and its hydrogen sulfide (H2S)-releasing derivative ATB-346 in rats with carrageenan-induced synovitis. (24237604)
2013
3
Correlation between manual 0.2T MRI assessment of synovitis and EULAR-OMERACT scores of the wrist in patients with rheumatoid arthritis. (24123587)
2013
4
Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients. (22039170)
2012
5
Simultaneous anterior and posterior synovectomies for treating diffuse pigmented villonodular synovitis. (22359272)
2012
6
Association of plasma n-6 and n-3 polyunsaturated fatty acids with synovitis in the knee: the MOST study. (22353693)
2012
7
Active foot synovitis in patients with rheumatoid arthritis: applying clinical criteria for disease activity and remission may result in underestimation of foot joint involvement. (22135142)
2012
8
Spondyloarthropathies: Synovitis in SpA-mast cells sail in (despite TNF blockade). (22025122)
2011
9
Pigmented villonodular synovitis of the temporomandibular joint: case report and review of the literature. (21310347)
2011
10
Dose range finding study for the efficacy of meloxicam administered prior to sodium urate-induced synovitis in cats. (21672128)
2011
11
The 'disconnect' between synovitis and erosion in rheumatoid arthritis: a result of treatment or intrinsic to the disease process itself? (21233504)
2011
12
Binding immunoglobulin protein resolves rheumatoid synovitis: a xenogeneic study using rheumatoid arthritis synovial membrane transplants in SCID mice. (21914218)
2011
13
Comparison of the manual and computer-aided techniques for evaluation of wrist synovitis using dynamic contrast-enhanced MRI on a dedicated scanner. (21030175)
2011
14
Pigmented villonodular synovitis presenting as a baker cyst. (22263199)
2011
15
Intra-articular chromic phosphate (A^A^P) in the treatment of diffuse pigmented villonodular synovitis. (20685177)
2011
16
Thoracic facet joint synovitis causing thoracic spinal cord compression and myelopathy in a patient with rheumatoid arthritis. (21733967)
2011
17
Synovitis in spondyloarthritides. (22279511)
2011
18
MRI of macrophages in infectious knee synovitis. (20489072)
2010
19
Reliability of ultrasonography to detect synovitis in rheumatoid arthritis: a systematic literature review of 35 studies (1,415 patients). (20391478)
2010
20
Expression of I^-1,4-galactosyltransferase I in a surgically-induced rat model of knee osteoarthritic synovitis. (21162957)
2010
21
Pigmented villonodular synovitis of the knee in skeletally immature patients. (21455469)
2010
22
Arthroscopic treatment of localized and diffuse pigmented villonodular synovitis of the knee. (21874741)
2010
23
Is remitting seronegative symmetrical synovitis with pitting edema (RS3PE) a subset of rheumatoid arthritis? (19217650)
2010
24
Pigmented villonodular synovitis of the elbow treated with the Tsuge wide joint exposure technique. (20192154)
2010
25
Persistent low grade synovitis without erosive progression in magnetic resonance imaging of rheumatoid arthritis patients treated with infliximab over 1 year. (19504146)
2009
26
Prolonged synovitis in pediatric Lyme arthritis cannot be predicted by clinical or laboratory parameters. (19194735)
2009
27
Magnetic resonance spin-labeling perfusion imaging of synovitis in inflammatory arthritis at 3.0 T. (19172323)
2009
28
All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis. (20009973)
2009
29
Power Doppler ultrasound of rheumatoid synovitis: quantification of vascular signal and analysis of interobserver variability. (19255756)
2009
30
Lyme arthritis presenting as transient synovitis of the hip. (18519920)
2008
31
Fat-saturated MR imaging in the detection of inflammatory facet arthropathy (facet synovitis) in the lumbar spine. (18489631)
2008
32
Pigmented villonodular synovitis of the zygoapophyseal joint: a case report. (18708919)
2008
33
Similarities between giant cell tumor of bone, giant cell tumor of tendon sheath, and pigmented villonodular synovitis concerning ultrastructural cytochemical features of multinucleated giant cells and mononuclear stromal cells. (16825116)
2006
34
Changes in MMP-2 and -9 activity and MMP-8 reactivity after amphotericin B induced synovitis and treatment with bufexamac. (16901276)
2006
35
Strong expression of Bcl-2 in pigmented villonodular synovitis of the knee with aggressive clinical behaviour. (15903030)
2005
36
Involvement of neurotrophins and their receptors in spondyloarthritis synovitis: relation to inflammation and response to treatment. (15817657)
2005
37
Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitis. (15186320)
2004
38
Novel HLA B*2714 and B*2708 allele associations in seronegative spondarthritis patients and haemophilia patients with chronic synovitis in India. (12889998)
2003
39
Pigmented villonodular synovitis of the foot: MR findings. (12951553)
2003
40
Ectopic germinal center formation in rheumatoid synovitis. (12727633)
2003
41
Lymphoid neogenesis in rheumatoid synovitis. (11441118)
2001
42
Intraarticular osteoid osteoma associated with synovitis: a possible role of cyclooxygenase-2 expression by osteoblasts in the nidus. (11048802)
2000
43
Pigmented villonodular synovitis of the knee: a description of two cases treated in arthroscopy. (10052239)
1998
44
Pigmented villonodular synovitis and synovial chondromatosis arthroscopically diagnosed and treated in the same elbow. (9043614)
1997
45
Pigmented villonodular synovitis arising from the sheath of the extensor hallucis longus in an eight-month-old infant. (8519122)
1993
46
Pigmented villonodular synovitis of the knee. The results of total arthroscopic synovectomy, partial, arthroscopic synovectomy, and arthroscopic local excision. (1463472)
1992
47
Pigmented villonodular synovitis in the sacral joint with extensive bone destruction in a child. (1437885)
1992
48
Localized pigmented villonodular synovitis of the knee mimicking meniscal injury. (3801100)
1986
49
Pigmented villonodular synovitis associated with psoriatic polyarthropathy: and electron microscopic and immunocytochemical study. (6481528)
1984
50
Eosinophilic fasciitis (Shulman syndrome) with prominent synovitis. (7107221)
1982

Genetic Variations for Synovitis

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Expression for genes affiliated with Synovitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Synovitis

Search GEO for disease gene expression data for Synovitis.

Pathways for genes affiliated with Synovitis

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29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN
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Compounds for genes affiliated with Synovitis

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Synovitis according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1paraffin4411.4PTHLH, CSF1, CSF1R, PDGFRB, IBSP, BGLAP
2creatinine4411.4TNFRSF11B, PTHLH, ACP5, MMP9, MMP1, TNFSF11
3vegf4411.3SPP1, MMP9, MMP1, TNFSF11, CSF1, CSF1R
41,25 dihydroxy vitamin d34411.3TNFRSF11B, PTHLH, ACP5, TNFSF11, CSF1, CSF1R
5calcitriol44 59 11 2414.3BGLAP, CALCR, MMP1, PDGFRB, CSF1, TNFSF11
6cysteine4411.3MMP9, MMP1, IBSP, TNFRSF11B, TNFSF11, BGLAP
7vitamin d4411.3CALCR, SPP1, PTHLH, ACP5, TNFRSF11B, PDGFRB
8dexamethasone44 49 28 1114.3TNFSF11, MMP9, ACP5, BGLAP, TNFRSF11B, SPP1
9phosphatidylinositol4411.3CSF1, SPP1, TNFRSF11B, MMP9, PTHLH, CSF1R
10zoledronic acid4411.2BGLAP, IBSP, TNFRSF11B, MMP1, PTHLH, TNFSF11
11testosterone44 59 11 2414.2MMP9, SPP1, PTHLH, MMP1, PDGFRB, TNFRSF11B
12hydroxyproline44 11 2413.2MMP9, BGLAP, TNFRSF11B, ACP5, PTHLH, MMP1
13hydroxyapatite4411.2PTHLH, SPP1, ACP5, TNFRSF11B, TNFSF11, IBSP
14tgf beta14411.2CSF1, PDGFRB, PTHLH, SPP1, MMP9, MMP1
15tartrate4411.2TNFSF11, CSF1, CALCR, BGLAP, ACP5, PTHLH
16cyclosporin a44 28 5913.1TNFSF11, CALCR, BGLAP, TNFRSF11B, MMP9, MMP1
17titanium4411.1IBSP, BGLAP, SPP1, ACP5, TNFRSF11B, TNFSF11
18ns 39844 5912.1MMP9, TNFRSF11B, TNFSF11, CSF1, BGLAP, MMP1
1925-hydroxyvitamin d4411.1BGLAP, TNFSF11, PTHLH, SPP1, TNFRSF11B, ACP5
20tyrosine4411.1ACP5, MMP9, TNFRSF11B, TNFSF11, CSF1, SPP1
21phosphorus4411.1TNFSF11, PTHLH, BGLAP, SPP1, ACP5, TNFRSF11B
22clodronate44 49 1113.1TNFSF11, MMP1, ACP5, PTHLH, TNFRSF11B
23ascorbic acid44 2412.1MMP1, TNFRSF11B, SPP1, TNFSF11, CSF1, IBSP
24pamidronate44 49 1113.1MMP1, PTHLH, TNFSF11, TNFRSF11B, BGLAP
25pyridinoline4411.1ACP5, PTHLH, TNFRSF11B, IBSP, BGLAP
26heparin44 28 11 2414.1IBSP, SPP1, BGLAP, ACP5, TNFRSF11B, TNFSF11
27deoxypyridinoline4411.1TNFSF11, BGLAP, IBSP, TNFRSF11B, ACP5
28alendronate44 49 1113.0BGLAP, MMP1, TNFRSF11B, TNFSF11, PTHLH
29serine4411.0MMP1, TNFRSF11B, TNFSF11, CSF1, BGLAP, CSF1R
30pd 98,0594411.0CSF1R, CSF1, TNFSF11, MMP1, IBSP, SPP1
31procollagen4411.0TNFSF11, ACP5
32estradiol44 11 2413.0IBSP, CALCR, PTHLH, ACP5
33ibandronate44 1112.0TNFSF11, TNFRSF11B, IBSP, BGLAP
34infliximab44 49 1113.0SPP1, MMP1, TNFRSF11B, BGLAP, TNFSF11
35retinoic acid44 2412.0PDGFRB, SPP1, PTHLH, MMP9, MMP1, BGLAP
36matrigel4411.0PTHLH, PDGFRB, MMP1, IBSP
37pge24411.0MMP9
38genistein44 28 59 2 11 2415.9MMP9, SPP1, TNFRSF11B, TNFSF11, MMP1, PDGFRB
39vitamin k24410.9BGLAP, CSF1, TNFRSF11B, TNFSF11
40cycloheximide4410.9CSF1R, IBSP
41rantes4410.9CALCR, CSF1, ACP5
42celecoxib44 59 28 49 11 2415.9MMP1, CSF1, MMP9, TNFRSF11B, TNFSF11
43prostaglandin4410.9TNFRSF11B, CSF1, TNFSF11, MMP1
44geranylgeranyl pyrophosphate4410.9TNFSF11, TNFRSF11B, MMP9, MMP1
45azathioprine44 49 2 1113.8TNFSF11, TNFRSF11B, ACP5, PTHLH, BGLAP
46prednisolone44 28 1112.7BGLAP, TNFRSF11B, MMP1, PTHLH, CSF1
47etanercept44 49 1112.6TNFSF11, MMP1, CSF1, TNFRSF11B
48indomethacin44 59 28 1113.6SPP1, CSF1
49sb 20358044 5911.6SPP1, MMP9, MMP1, TNFRSF11B, TNFSF11, BGLAP
50troglitazone44 28 59 1113.4MMP1, SPP1, PTHLH, MMP9, CSF1

GO Terms for genes affiliated with Synovitis

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16Gene Ontology
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Cellular components related to Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.7SPP1, PVR, BGLAP, CSF1, TNFSF11, TNFRSF11B
2membrane-bounded vesicleGO:03198810.5SPP1, BGLAP
3extracellular regionGO:00557610.5BGLAP, IBSP, TNFSF11, TNFRSF11B, MMP1, MMP9

Biological processes related to Synovitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019810.9IBSP, TNFRSF11B, MMP1, MMP9, SPP1
2macrophage differentiationGO:03022510.8MMP9, CSF1, CSF1R
3osteoclast differentiationGO:03031610.8TNFSF11, CSF1, CSF1R
4skeletal system developmentGO:00150110.8BGLAP, TNFRSF11B, MMP9, PTHLH
5osteoclast proliferationGO:00215810.7TNFSF11, CSF1
6regulation of bone resorptionGO:04512410.6CSF1R, BGLAP
7ossificationGO:00150310.6IBSP, CSF1, TNFSF11
8positive regulation of bone resorptionGO:04578010.6SPP1, TNFSF11
9phosphatidylinositol metabolic processGO:04648810.5CSF1R, PDGFRB
10response to vitamin DGO:03328010.2SPP1, BGLAP

Molecular functions related to Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.6SPP1, TNFRSF11B, TNFSF11, CSF1

Products for genes affiliated with Synovitis

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  • Antibodies
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Sources for Synovitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet