MCID: SYP003
MIFTS: 56

Syphilis malady

Infectious diseases category

Summaries for Syphilis

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Syphilis is a sexually transmitted disease caused by bacteria. it infects the genital area, lips, mouth, or anus of both men and women. you usually get syphilis from sexual contact with someone who has it. it can also pass from mother to baby during pregnancy. the early stage of syphilis usually causes a single, small, painless sore. sometimes it causes swelling in nearby lymph nodes. if you do not treat it, syphilis usually causes a non-itchy skin rash, often on your hands and feet. many people do not notice symptoms for years. symptoms can go away and come back. the sores caused by syphilis make it easier to get or give someone hiv during sex. if you are pregnant, syphilis can cause birth defects, or you could lose your baby. in rare cases, syphilis causes serious health problems and even death. syphilis is easy to cure with antibiotics if you catch it early. correct usage of latex condoms greatly reduces, but does not completely eliminate, the risk of catching or spreading syphilis. nih: national institute of allergy and infectious diseases

MalaCards: Syphilis, also known as syphilis, unspecified, is related to primary syphilis and hepatitis. An important gene associated with Syphilis is CD40LG (CD40 ligand), and among its related pathways are Primary immunodeficiency and B cell receptor signaling pathway. The drug erythromycin pwdr and the compounds sulfolipid i and sandoglobulin have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and lymph node, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Disease Ontology:8 A primary bacterial infectious disease that is a sexually transmitted systemic disease, has material basis in treponema pallidum subsp pallidum, which is transmitted by sexual contact, transmitted by blood product transfusion, transmitted by congenital method from mother to fetus or transmitted by contact with infectious lesions. if left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

CDC:3 Syphilis is an STD that can have very serious complications when left untreated.

Wikipedia:63 Syphilis is a sexually transmitted infection caused by the spirochete bacterium Treponema pallidum... more...

Aliases & Classifications for Syphilis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 34MeSH, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

syphilis 8 10 44 33 60
syphilis, unspecified 8
syphilitic chancre 8
syphilis nos 8


External Ids:

Disease Ontology8 DOID:4166
MeSH34 D002601
ICD1025 A53.9

Related Diseases for Syphilis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Syphilis family:

Late Congenital Syphilis Early Congenital Syphilis
Primary Syphilis Congenital Syphilis

Diseases related to Syphilis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 272)
idRelated DiseaseScoreTop Affiliating Genes
1primary syphilis31.4ZBTB32, PDE6D
2hepatitis30.9CD40LG, ABCB7, CP
3hepatitis b30.6FN1, CD79A, ABCB7
4hepatitis c30.6CCR5, CD40LG, ABCB7
5nephrotic syndrome30.5CD79A
6uveitis30.4CCR5
7meningitis30.2CD79A
8toxoplasmosis30.2CD79A, CD40LG
9arthritis30.2CCR5, FN1
10tuberculosis30.2FN1, CD79A, CD209, CP
11herpes simplex30.2CD79A
12sarcoidosis30.2CCR5
13dermatitis30.2CD79A
14antiphospholipid syndrome30.2APOH, CD40LG, CD79A
15acquired immunodeficiency syndrome30.1CCR5
16rubella30.1CD79A, CD40LG
17vasculitis30.1APOH, FN1, CD40LG, CD79A
18systemic lupus erythematosus30.1CCR5, APOH, CD40LG, CD79A
19psoriasis30.1FN1
20malaria30.0CP
21hypertension30.0CD79A, FN1
22thrombocytopenia29.9ABCB7, CD79A, CD40LG, APOH
23q fever29.6CD79A
24leptospirosis29.6CD40LG, FN1
25viral hepatitis29.6ABCB7, FN1
26toxocariasis29.6TES
27infectious mononucleosis29.6CD40LG, CD79A
28behcet's disease29.6CCR5, APOH, CP
29inflammatory bowel disease29.6CD79A
30atherosclerosis29.6CCR5, APOH, FN1, CD40LG, CD209, CP
31rheumatoid arthritis29.6CCR5, APOH, FN1, CD40LG, CD79A, CP
32congenital syphilis11.2
33secondary syphilis11.1
34latent syphilis10.8
35cardiovascular syphilis10.8
36tertiary syphilis10.8
37early congenital syphilis10.6
38yaws10.6
39gonorrhea10.6
40late congenital syphilis10.5
41bejel10.4
42gummatous syphilis10.4
43interstitial keratitis10.3
44keratitis10.3
45lymphogranuloma venereum10.3
46glomerulonephritis10.3
47periostitis10.3
48tonsillitis10.2
49leprosy10.2
50choroiditis10.2

Graphical network of the top 20 diseases related to Syphilis:



Diseases related to syphilis

Clinical Features for Syphilis

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Drugs & Therapeutics for Syphilis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Syphilis

Drug clinical trials:

Search ClinicalTrials for Syphilis

Search NIH Clinical Center for Syphilis

Search CenterWatch for Syphilis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Syphilis

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Anatomical Context for Syphilis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Syphilis:

32
Testes, Skin, Lymph node, Bone, Liver, Tonsil, Tongue, Spinal cord, Prostate, Eye, T cells, Heart, Temporal lobe, Trachea, Placenta, Uterus, Breast, Adrenal gland, Lung, Kidney, Retina, Brain, Spleen, Pituitary

Animal Models for Syphilis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Syphilis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.2NLRP12, ZBTB32, FN1, CD40LG, CD79A, IKBKG
2MP:00053768.8APOH, EXTL3, NLRP12, CCR5, FN1, CD40LG
3MP:00053878.7CCR5, NLRP12, ZBTB32, FN1, CD40LG, CD79A
4MP:00107688.6APOH, FEZF1, EXTL3, CCR5, PPIB, STIL
5MP:00053848.5CP, CCR5, NLRP12, EXTL3, FEZF1, STIL

Publications for Syphilis

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Sources:
50PubMed
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Articles related to Syphilis:

(show top 50)    (show all 2001)
idTitleAuthorsYear
1
Regulatory T cells in peripheral blood and cerebrospinal fluid of syphilis patients with and without neurological involvement. (24244772)
2013
2
Trend in prevalence of syphilis among voluntary blood donors in Xi'an, China from 2006 to 2010. (24291114)
2013
3
Notes from the field: repeat syphilis infection and HIV coinfection among men who have sex with men--Baltimore, Maryland, 2010-2011. (23945772)
2013
4
The social and policy context of curing syphilis: Commentary on Francis (2013). (23857520)
2013
5
Geographical information systems-based spatial analysis and implications for syphilis interventions in Jiangsu province, People's Republic of China. (23242681)
2012
6
Diffuse pattern essential syphilitic alopecia: an unusual form of secondary syphilis. (22788824)
2012
7
Efficacy of ceftriaxone and doxycycline in the treatment of early syphilis. (22119040)
2012
8
Examining self and partners for syphilis among men who have sex with men: five US cities, 2009-2011. (23258824)
2012
9
Secondary syphilis with intestinal involvement: description of a case. (18833054)
2008
10
An evaluation of the relative sensitivities of the venereal disease research laboratory test and the Treponema pallidum particle agglutination test among patients diagnosed with primary syphilis. (18080352)
2007
11
Treponema pallidum elicits innate and adaptive cellular immune responses in skin and blood during secondary syphilis: a flow-cytometric analysis. (17299719)
2007
12
Secondary syphilis presenting as vertigo. (17052426)
2006
13
Pressure ulcer-like presacral gummata in a patient with tertiary syphilis. (16722855)
2005
14
Syphilitic gumma--cutaneous tertiary syphilis. (15196182)
2004
15
Congenital syphilis after maternal treatment for syphilis during pregnancy. (11904625)
2002
16
Primary and secondary syphilis--United States, 2000-2001. (12433021)
2002
17
Mucocutaneous manifestations of secondary syphilis in north Indian patients: a changing scenario? (11349464)
2001
18
Outbreak of primary and secondary syphilis--Baltimore City, Maryland, 1995. (8596531)
1996
19
Congenital syphilis mimicking child abuse. (8545191)
1995
20
Pathology of the umbilical cord in congenital syphilis: analysis of 25 specimens using histochemistry and immunofluorescent antibody to Treponema pallidum. (7628852)
1995
21
Maternal syphilis in Michigan: the challenge to prevent congenital syphilis. (7616859)
1995
22
Congenital syphilis. (1616684)
1992
23
Congenital syphilis in the past: slaves at Newton Plantation, Barbados, West Indies. (1443091)
1992
24
Congenital syphilis in a twin gestation. (1448395)
1992
25
Primary and secondary syphilis--United States, 1981-1990. (2023578)
1991
26
Hepatitis and glomerulonephritis in secondary syphilis. (1810584)
1991
27
Congenital syphilis: an emerging emergency. (1876511)
1991
28
Syphilis, neurosyphilis, penicillin, and AIDS. (2037785)
1991
29
Granulomatous hepatitis in secondary syphilis. (2189840)
1990
30
Effectiveness of penicillin G benzathine therapy for primary and secondary syphilis in HIV infection. (2273134)
1990
31
Early and congenital syphilis. (2687743)
1989
32
The treatment of gonorrhea, syphilis, chancroid, lymphogranuloma venereum, and granuloma inguinale. (3042224)
1988
33
Early congenital syphilis (a review). (6673413)
1983
34
The liver in secondary syphilis. (7123342)
1982
35
Corymbose secondary syphilis: occurrence as a solitary group of lesions. (7352757)
1980
36
Bell's palsy and secondary syphilis: CSF spirochetes detected by immunofluorescence. (365078)
1978
37
Antibiotics--how to use them in 1977-1978: Primary syphilis. Gonorrhea. Nongonococcal urethritis. Gonococcal dermatitis-arthritis syndrome. (628627)
1978
38
Treatment of congenital syphilis. (1010784)
1976
39
Nephrotic syndrome of congenital syphilis. Biopsy studies in four cases. (4274228)
1974
40
Congenital syphilis, a new (old) diagnostic problem. (4684335)
1973
41
An unusual solitary lesion of secondary syphilis. (6019000)
1967
42
AORTIC INCOMPETENCE ASSOCIATED WITH CONGENITAL SYPHILIS. (14332082)
1965
43
Synovitis of the knee joints in late congenital syphilis. Clutton's joints. (13871252)
1962
44
A case for diagnosis: granuloma of the nose? tertiary syphilis, treatment resistant? (14877301)
1952
45
Tertiary syphilis with multiple gummas of skin and bones responding poorly to penicillin therapy. (14789222)
1951
46
Penicillin treatment of cardiovascular syphilis. (15406001)
1950
47
Tertiary syphilis. (15394654)
1949
48
Pityriasis rosea resembling secondary syphilis. (20983406)
1946
49
Studies on the biologic relationship between the causative agents of syphilis, yaws and venereal spirochetosis of rabbits. (21000086)
1946
50
DIFFERENTIATION BETWEEN YAWS AND SYPHILIS. (18741593)
1930

Genetic Variations for Syphilis

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Expression for genes affiliated with Syphilis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Syphilis

Search GEO for disease gene expression data for Syphilis.

Pathways for genes affiliated with Syphilis

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Sources:
29KEGG, 37NCBI BioSystems Database
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Pathways related to Syphilis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0IKBKG, CD79A, CD40LG
2
Hide members
9.9IKBKG, CD79A, CD40LG, CCR5

Compounds for genes affiliated with Syphilis

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Syphilis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1sulfolipid i4410.6CD79A, CD40LG
2sandoglobulin4410.6CD40LG, CD79A
3gluten4410.5CD79A, APOH
4uric acid44 2411.5ABCB7, APOH
5mannan4410.5CD209, CD79A, CD40LG
6pmma4410.5CD79A, CD40LG, FN1
7silicone4410.4FN1, CD40LG, CD79A
8cardiolipin44 1111.4CD79A, CD40LG, APOH
9vancomycin44 1111.4CD40LG, CD79A
10cytidine44 11 2412.4IKBKG, CD79A, CD40LG
11anti-fungal4410.4PPIB, CD40LG, CD79A
12phenytoin44 49 28 1113.4CD40LG, CD79A, CP
13rituximab44 49 1112.4APOH, CD40LG, CD79A
14ivig4410.4CD79A, CD40LG, APOH, CCR5
15dextran sulfate4410.4CCR5, APOH, FN1, CD40LG
16allergens4410.3CD209, CD79A, CD40LG
17cocaine44 1111.3CCR5, APOH, CD40LG, CD209
18pneumococcal4410.3CD40LG, CD79A
19betacarotene4410.3CP, CD79A, APOH
20vitamin b124410.3APOH, CD40LG, CD79A, CP
21mannose4410.3CCR5, APOH, CD79A, CD209
22polyethylene glycol4410.3CD79A, CD40LG, FN1
23sialic acid4410.3APOH, CD79A, ABCB7, CP
24blys4410.3CD40LG, CD79A
25thyroxine44 2411.3CD40LG, CD79A, ABCB7, CP
26folate4410.2APOH, CD40LG, CD79A, CP
27polyacrylamide4410.2CCR5, APOH, FN1, ABCB7
28aspirin44 49 28 2413.2CD79A, CD40LG, FN1, APOH
29hydroxychloroquine44 1111.2APOH, CD40LG
30vitamin-e4410.2CCR5, ABCB7, CP
31tuberculin4410.2CD79A, CD40LG
32polysaccharide4410.2CCR5, FN1, CD40LG, CD79A, CD209
33agar4410.2FN1, CD40LG, CD79A, CP
34galactose4410.1CD209, CD79A, APOH
35indomethacin44 59 28 1113.1FN1, CD40LG, CD79A, CP
36cyclosporin a44 28 5912.1CD79A, CD40LG, FN1, PPIB, CCR5
37vitamin d4410.0CP, CD79A, FN1, CCR5
38fibrinogen4410.0APOH, FN1, CD40LG, CD79A, ABCB7, CP
39lactate4410.0APOH, FN1, CD40LG, CD79A, ABCB7, CP
40creatinine4410.0APOH, FN1, CD40LG, CD79A, ABCB7, CP
41latex449.9FN1, APOH, CCR5
42dexamethasone44 49 28 1112.9CCR5, FN1, CD40LG, CD79A, CD209, CP
43alanine449.9CCR5, FN1, CD40LG, CD79A, ABCB7, CP
44zinc44 2410.9CCR5, APOH, ZBTB32, IKBKG, ABCB7, CP
45glutamate449.8CCR5, NLRP12, APOH, CD40LG, CD79A, ABCB7
46estrogen449.8CCR5, NLRP12, APOH, FN1, CD40LG, CD79A
47cysteine449.7CCR5, NLRP12, FN1, CD40LG, CD79A, CP
48biotin44 11 2411.7FN1, CD40LG, CD79A
49heparin44 28 11 2412.7CP, CCR5, APOH, PPIB, FN1, CD40LG
50arginine449.7CCR5, NLRP12, APOH, FN1, CD40LG, CD79A

GO Terms for genes affiliated with Syphilis

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16Gene Ontology
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Biological processes related to Syphilis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:04210010.2CD79A, CD40LG

Products for genes affiliated with Syphilis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Syphilis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet