MCID: SYP003
MIFTS: 53

Syphilis malady

Categories: Infectious diseases, Neuronal diseases, Bone diseases

Aliases & Classifications for Syphilis

Summaries for Syphilis

MedlinePlus : 41 syphilis is a sexually transmitted disease caused by bacteria. it infects the genital area, lips, mouth, or anus of both men and women. you usually get syphilis from sexual contact with someone who has it. it can also pass from mother to baby during pregnancy. the early stage of syphilis usually causes a single, small, painless sore. sometimes it causes swelling in nearby lymph nodes. if you do not treat it, syphilis usually causes a non-itchy skin rash, often on your hands and feet. many people do not notice symptoms for years. symptoms can go away and come back. the sores caused by syphilis make it easier to get or give someone hiv during sex. if you are pregnant, syphilis can cause birth defects, or you could lose your baby. in rare cases, syphilis causes serious health problems and even death. syphilis is easy to cure with antibiotics if you catch it early. correct usage of latex condoms greatly reduces, but does not completely eliminate, the risk of catching or spreading syphilis. nih: national institute of allergy and infectious diseases

MalaCards based summary : Syphilis, also known as chancre, is related to basilar artery occlusion and early yaws, and has symptoms including syphilitic chancre, fever and pelvic pain. An important gene associated with Syphilis is APOH (Apolipoprotein H), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Penicillin G and Procaine have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and heart, and related phenotypes are homeostasis/metabolism and mortality/aging

CDC : 3 You should get tested regularly if you are pregnant, are a man who has sex with men, have HIV infection, and/or have partner(s) who have tested positive for syphilis.

Disease Ontology : 12 A primary bacterial infectious disease that is a sexually transmitted systemic disease, has material basis in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

Wikipedia : 71 Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies... more...

Related Diseases for Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 341)
id Related Disease Score Top Affiliating Genes
1 basilar artery occlusion 29.4 CD40LG CD79A EXTL3
2 early yaws 29.1 B2M CD40LG CD79A
3 congenital syphilis 12.4
4 tertiary syphilis 12.3
5 latent syphilis 12.3
6 secondary syphilis 12.3
7 primary syphilis 12.2
8 cardiovascular syphilis 12.2
9 late congenital syphilis 12.2
10 early congenital syphilis 12.1
11 gummatous syphilis 12.1
12 bejel 11.8
13 asymptomatic neurosyphilis 11.6
14 neurosyphilis 11.6
15 tertiary neurosyphilis 11.5
16 syphilitic aseptic meningitis 11.5
17 tabes dorsalis 11.0
18 smallpox 11.0
19 variola major 10.7
20 mikulicz disease 10.7
21 chronic rhinitis 10.7
22 variola minor 10.7
23 idiopathic hypertrophic pachymeningitis 10.7
24 progressive locomotor ataxia 10.7
25 syphilitic spinal sclerosis 10.7
26 alcoholic neuropathy 10.4 CD40LG CD79A
27 camptodactyly vertebral fusion 10.4 CD40LG CD79A
28 spinal polio 10.4 CD40LG CD79A
29 rabies 10.4 CD40LG CD79A
30 unilateral retinoblastoma 10.4 CD40LG CD79A
31 mesangial proliferative glomerulonephritis 10.3 CD40LG CD79A
32 delta chain disease 10.3 CD40LG CD79A
33 discitis 10.3 CD40LG CD79A
34 spinal canal and spinal cord meningioma 10.3 CD40LG CD79A
35 trichostrongyloidiasis 10.3 CD40LG CD79A
36 colloid adenoma 10.3 CD40LG CD79A
37 heart septal defect 10.3 CD40LG CD79A
38 retinal microaneurysm 10.3 CD40LG CD79A
39 pediatric meningioma 10.3 CD40LG CD79A
40 tonsil cancer 10.3 CD40LG CD79A
41 indomethacin antenatal infection 10.3 CD40LG CD79A
42 diabetic peripheral angiopathy 10.3 CD40LG EXTL3
43 postcricoid region cancer 10.3 CD40LG CD79A
44 cysticercosis 10.3 CD40LG EXTL3
45 beach ear 10.3 CD40LG CD79A
46 acute kidney tubular necrosis 10.3 CD40LG CD79A
47 atheroembolism of kidney 10.3 CD40LG CD79A
48 partial sensory epilepsy 10.3 CD40LG CD79A
49 myeloid leukemia 10.3 APOH CD40LG
50 exhibitionism 10.3 APOH CD40LG

Comorbidity relations with Syphilis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Hypertension, Essential Schizophreniform Disorder

Graphical network of the top 20 diseases related to Syphilis:



Diseases related to Syphilis

Symptoms & Phenotypes for Syphilis

UMLS symptoms related to Syphilis:


syphilitic chancre, fever, pelvic pain, pruritus, gummatous inflammation

MGI Mouse Phenotypes related to Syphilis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.65 APOH B2M CAT CD40LG CD79A EXTL3
2 mortality/aging MP:0010768 9.32 TPR APOH B2M CAT CD40LG EXTL3

Drugs & Therapeutics for Syphilis

Drugs for Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 87)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin G Approved, Vet_approved Phase 4,Phase 3 61-33-6 5904
2
Procaine Approved, Investigational, Vet_approved Phase 4,Phase 3 59-46-1 4914
3
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Early Phase 1 564-25-0 54671203
4
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
5
Tenofovir Approved, Investigational Phase 4 147127-20-6 464205
6 Anti-Bacterial Agents Phase 4,Phase 3,Early Phase 1
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
8 Penicillin G Benzathine Phase 4,Phase 3
9 Penicillin G Procaine Phase 4,Phase 3
10 penicillins Phase 4,Phase 3
11 Antimalarials Phase 4,Phase 3,Early Phase 1
12 Antiparasitic Agents Phase 4,Phase 3,Early Phase 1
13 Antiprotozoal Agents Phase 4,Phase 3,Early Phase 1
14 Anti-HIV Agents Phase 4
15 Anti-Retroviral Agents Phase 4
16 Antiviral Agents Phase 4
17 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3
18 Reverse Transcriptase Inhibitors Phase 4
19
Guaifenesin Approved, Vet_approved Phase 3 93-14-1 3516
20
Heroin Approved, Illicit Phase 3 561-27-3 5462328
21
Methadone Approved Phase 3 76-99-3 4095
22
Azithromycin Approved Phase 3 83905-01-5 55185 53477736 447043
23
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
24
Adalimumab Approved Phase 3 331731-18-1 16219006
25
chloroquine Approved, Vet_approved Phase 3 54-05-7 2719
26
Pyrimethamine Approved, Vet_approved Phase 3 58-14-0 4993
27
Sulfadoxine Approved Phase 3 2447-57-6 17134
28
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
29
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
30 Analgesics Phase 3
31 Analgesics, Opioid Phase 3
32 Antitussive Agents Phase 3
33 Central Nervous System Depressants Phase 3
34 Chlorpheniramine, phenylpropanolamine drug combination Phase 3
35 Narcotics Phase 3
36 Peripheral Nervous System Agents Phase 3,Phase 1,Phase 2
37 Respiratory System Agents Phase 3
38 Vaccines Phase 3,Phase 2
39 Antirheumatic Agents Phase 3
40 Anti-Inflammatory Agents Phase 3
41 Analgesics, Non-Narcotic Phase 3
42 Anti-Inflammatory Agents, Non-Steroidal Phase 3
43 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
44 mometasone furoate Phase 3 83919-23-7
45 Antimetabolites Phase 3
46 Antimetabolites, Antineoplastic Phase 3
47 Dermatologic Agents Phase 3
48 Folic Acid Antagonists Phase 3
49 Immunosuppressive Agents Phase 3
50 Vitamin B Complex Phase 3

Interventional clinical trials:

(show top 50) (show all 114)
id Name Status NCT ID Phase
1 Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study Completed NCT02611765 Phase 4
2 Serological Response to Retreatment of Serofast Early Syphilis Cases With Benzathine Penicillin Recruiting NCT02884115 Phase 4
3 One Dose Versus Three Weekly Doses of Benzathine Penicillin G for Patients With Early Syphilis Recruiting NCT02857959 Phase 4
4 The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings Recruiting NCT02871505 Phase 4
5 Expanded PrEP Implementation in Communities in NSW Recruiting NCT02870790 Phase 4
6 Tenofovir/Emtricitabine With Doxycycline for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative MSM Not yet recruiting NCT02844634 Phase 4
7 PrEP Implementation for Mothers in Antenatal Care Not yet recruiting NCT03070600 Phase 4
8 Introduction Study of Dual HIV & Syphilis Rapid Diagnostic Tests in Antenatal Clinics in Colombia Unknown status NCT02454816 Phase 2, Phase 3
9 (Men Who Have Sex With Men) MSM Community Intervention Trial Unknown status NCT01068015 Phase 3
10 Injecting Drug Use Community Intervention Trial Unknown status NCT01108614 Phase 3
11 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
12 Azithromycin/Bicillin Syphilis Completed NCT00031499 Phase 3
13 Male Circumcision for HIV Prevention in Rakai, Uganda Completed NCT00425984 Phase 3
14 Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission Completed NCT00213083 Phase 3
15 Single-dose Azithromycin for the Treatment of Yaws Completed NCT01382004 Phase 3
16 Effectiveness of a Community-level HIV/STD Prevention Intervention in Promoting Safer Sexual Behaviors in High-risk Populations Completed NCT00710060 Phase 3
17 MEMA Kwa Vijana Trial: Impact of an Adolescent Sexual and Reproductive Health Intervention in Mwanza, Tanzania Completed NCT00248469 Phase 3
18 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
19 Protecting From Pneumococcus in Early Life (The PROPEL Trial) Recruiting NCT02628886 Phase 3
20 Evaluation of the Effectiveness and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo, in Subjects With Rheumatoid Arthritis (RA) Who Are Taking an Existing Medication Called a Tumour Necrosis Factor Alpha Inhibitor But Have Active Di Recruiting NCT02760433 Phase 3
21 Evaluation of the Effectiveness and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo and Adalimumab, in Subjects With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate But Have Active Disease Recruiting NCT02760407 Phase 3
22 Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy Recruiting NCT01901094 Phase 3
23 Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa Terminated NCT01103063 Phase 3
24 Effectiveness of the Diaphragm for HIV Prevention Withdrawn NCT00121459 Phase 3
25 Safety, Acceptability and Preliminary Effectiveness of Carraguard™ (PC-515) in Preventing HIV/STI Transmission Completed NCT00213018 Phase 2
26 Safety, Acceptability and Preliminary Effectiveness of PC-515 for Vaginal Use as a Possible Microbicide Completed NCT00213031 Phase 2
27 Behavioral Intervention to Reduce Sexual and Injection Risks Among Female Sex Workers Who Also Inject Drugs in Mexico Completed NCT00840658 Phase 2
28 A Web-based Intervention Study to Reduce High-risk Sexual Behavior by Persons Living With HIV AIDS (PLWH) Completed NCT01198418 Phase 1, Phase 2
29 Lay Health Advisors for Sexually Transmitted Disease Prevention Completed NCT00207506 Phase 1, Phase 2
30 Safety and Efficacy Study of Human Autologous Hair Follicle Cells to Treat Androgenetic Alopecia Completed NCT01286649 Phase 1, Phase 2
31 Development of a Methamphetamine Early Intervention Completed NCT01174654 Phase 1, Phase 2
32 A Tolerability and Efficacy Study of TU-100 For The Treatment of Postoperative Ileus Completed NCT00266461 Phase 2
33 BufferGel and PRO 2000/5: Vaginal Gels to Prevent HIV Infection in Women Completed NCT00074425 Phase 2
34 Safer Sex Program for Young African-American Men Recruiting NCT01439503 Phase 2
35 Development of Immune Globulin Treatment for Avian Flu Terminated NCT00383071 Phase 2
36 Infections and Autoimmunity: Autobodies Screening in Multiple Sclerosis Unknown status NCT00230204 Phase 1
37 Computer-Assisted Tailored Cue-card Health [CATCH] Study Completed NCT01170741 Phase 1
38 Safety and Acceptability of Carraguard™ Among HIV-Negative Couples in Thailand Completed NCT00213057 Phase 1
39 Fecal Microbiota Transplantation in Pediatric Patients Active, not recruiting NCT02108821 Phase 1
40 Syphilis Treatment of Partners Trial Unknown status NCT02262390
41 A Methadone Maintenance Treatment Outcome Study in Three Provinces in China Unknown status NCT01315054
42 Human Papillomavirus Infection and Knowledge and Attitudes About HPV Vaccines Among Men Who Have Sex With Men (MSM) Unknown status NCT01300689
43 Repeat Sexually Transmitted Infection (STI) Patients: Tailored Socio-Contextual Intervention to Reduce HIV Risk Unknown status NCT01510262
44 The Impact of Short-term Financial Incentives on Sexual Behavior and HIV Incidence in Lesotho Unknown status NCT01589965 Early Phase 1
45 Illness Crisis Adapting in Early or Middle Phase of Patient With Chronic Disease: Study of Meta-cognition Model Unknown status NCT01964612
46 Evaluation of Therapeutic Management in ESBL-infected Patients or Carriers by Providing and Sharing a Free Tool - the "ESBL toolKIT"and Interventional Study of a Prospective Cohort of HIV+ Patients Searching for Possible Sexual Transmission Factors in ESB Unknown status NCT02011009
47 Preparing for Adolescent HIV Vaccine Trials in South Africa: Unknown status NCT00944879
48 The Contraceptive Choice Project Unknown status NCT01986439
49 Web-based Psychological Intervention to Coronary Artery Heart Disease Patients Unknown status NCT01998555
50 MBCGT and Psycho-physiological Stress Regulation Group for Depression and Psycho-physiological Stress Patient Unknown status NCT01894932

Search NIH Clinical Center for Syphilis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: chancre

Genetic Tests for Syphilis

Anatomical Context for Syphilis

MalaCards organs/tissues related to Syphilis:

39
Testes, Skin, Heart, Bone, Lymph Node, Liver, Tonsil

Publications for Syphilis

Articles related to Syphilis:

(show top 50) (show all 2267)
id Title Authors Year
1
Kissing chancre of primary syphilis. ( 28070492 )
2017
2
Factors associated with syphilis incidence in the HIV-infected in the era of highly active antiretrovirals. ( 28079818 )
2017
3
Cytokine Profiles in Aqueous Humor and Plasma of HIV-infected Individuals with Ocular Syphilis or Cytomegalovirus Retinitis. ( 28081374 )
2017
4
Serum microRNA profiles in patients with syphilis. ( 28079920 )
2017
5
Tracing partners of patients with syphilis infection remains challenging: experience of Geneva Hospital. ( 28081685 )
2017
6
Nodular tertiary syphilis in an immunocompetent patient. ( 27579755 )
2016
7
Auckland: city of syphilis? ( 27977652 )
2016
8
Warty mucosal lesions: Oral condyloma lata of secondary syphilis. ( 27679405 )
2016
9
Syphilis among middle-aged female sex workers in China: a three-site cross-sectional study. ( 27165644 )
2016
10
First report of tertiary syphilis presenting as lipoatrophic panniculitis in an immunocompetent patient. ( 27558164 )
2016
11
A case of acute myocardial infarction due to cardiovascular syphilis with aortic regurgitation and bilateral coronary ostial stenosis. ( 27873284 )
2016
12
Syphilis, a curable cause of acute polyarthritis. ( 27216318 )
2016
13
Periostitis in secondary syphilis with prozone phenomenon. ( 27498354 )
2016
14
Papulonodular secondary syphilis: a rare clinic presentation confirmed by serologic and histologic exams. ( 27192520 )
2016
15
Recurrent Jarisch-Herxheimer reaction in late latent syphilis. ( 26834029 )
2016
16
Differential declines in syphilis-related mortality in the United States, 2000-2014. ( 28007309 )
2016
17
Syphilis screening in pregnancy in the United Kingdom, 2010-2011: a national surveillance study. ( 27219027 )
2016
18
Unusual primary syphilis: Presentation of a likely case with a review of the stages of acquired syphilis, its differential diagnoses, management, and current recommendations. ( 26756536 )
2016
19
Pulmonary Consolidations due to Secondary Syphilis with Positive Bronchial Washing Immunohistochemistry. ( 26840562 )
2016
20
Population Dependency of Measles, Syphilis and Amebiasis in Japan and Community Evolution. ( 27795472 )
2016
21
Identifying and interpreting spatiotemporal variation in diagnoses of infectious syphilis among men, England: 2009 to 2013. ( 27147614 )
2016
22
Secondary syphilis presenting with aortitis and coronary ostial occlusion. ( 26670911 )
2016
23
Infectious and congenital syphilis notifications associated with an ongoing outbreak in northern Australia. ( 27080030 )
2016
24
High frequency of neurosyphilis in HIV-positive patients diagnosed with early syphilis. ( 27089861 )
2016
25
Secondary syphilis in the oral cavity and the role of the dental surgeon in STD prevention, diagnosis and treatment: a case series study. ( 27208390 )
2016
26
Bilateral Chorioretinitis as Syphilis Presentation: Multimodal Characterization and Therapy Response. ( 27790481 )
2016
27
Infant Deaths Due To Herpes Simplex Virus, Congenital Syphilis, and HIV in New York City. ( 26933212 )
2016
28
Out-of-Hospital screening for HIV, HBV, HCV and Syphilis in a vulnerable population, a public health challenge. ( 27626811 )
2016
29
Immune reconstitution inflammatory syndrome associated with secondary syphilis. ( 27566775 )
2016
30
Performance Evaluation of a Novel Chemiluminescence Assay Detecting Treponema Pallidum Antibody as a Syphilis Screening Method. ( 27215069 )
2016
31
Seroprevalence of hepatitis B and syphilis co-infection in human immunodeficiency virus-positive antiretroviral therapy attendees and human immunodeficiency virus-negative sexually transmitted infection attendees. ( 27190426 )
2016
32
Global challenges in human immunodeficiency virus and syphilis coinfection among men who have sex with men. ( 27626361 )
2016
33
Evaluation of the management of pregnancies and infants at risk for congenital syphilis: La RAcunion, 2008 to 2014. ( 27711044 )
2016
34
Cuba Validated as the First Country to Eliminate Mother-to-Child Transmission of Human Immunodeficiency Virus and Congenital Syphilis: Lessons Learned from the Implementation of the Global Validation Methodology. ( 27835624 )
2016
35
Clinical Evaluation of 2 Point-of-Care Lateral Flow Tests for the Diagnosis of Syphilis. ( 27631356 )
2016
36
Changing trend of HIV, Syphilis and Hepatitis C among Men Who Have Sex with Men in China. ( 27535092 )
2016
37
Syphilis in an Infant Acquired by Mouth-to-Mouth Transfer of Prechewed Food. ( 27573471 )
2016
38
Application of Goldmag immune probe in timely detection of syphilis based on GIS platform. ( 27152908 )
2016
39
Primary syphilis: An uncommon manifestation in the oral cavity. ( 27502894 )
2016
40
Risk profiles of neurosyphilis in HIV-negative patients with primary, secondary and latent syphilis: implications for clinical intervention. ( 26660338 )
2016
41
Syphilis in Pregnancy and Congenital Syphilis: Why Can We not yet Face This Problem? ( 27756083 )
2016
42
"The sins of the fathers will be visited upon the children": Congenital syphilis and leg braces pictorial depiction in eighteenth century Britain. ( 27421914 )
2016
43
Human Immunodeficiency Virus-Infected Man With Acute Visual Impairment and Panuveitis Due to Syphilis Despite Initially Negative Rapid Plasma Reagin. ( 27893602 )
2016
44
Characterization and six-month follow-up on a cohort of newborns with congenital syphilis. ( 27622443 )
2016
45
Global burden of maternal and congenital syphilis in 2008 and 2012: a health systems modelling study. ( 27443780 )
2016
46
Seroprevalence and diagnosis of HIV, HBV, HCV and syphilis infections among blood donors. ( 28009328 )
2016
47
The Global Epidemiology of Syphilis in the Past Century - A Systematic Review Based on Antenatal Syphilis Prevalence. ( 27167068 )
2016
48
The Significance of Isolated Reactive Treponemal Enzyme Immunoassay in the Diagnosis of Early Syphilis. ( 27196257 )
2016
49
Analytical and clinical comparison of Elecsys syphilis (RocheAr) - Architect syphilis TP and reformulated Architect syphilis TP (AbbottAr) assay. ( 28012638 )
2016
50
Skin rash: a manifestation of early congenital syphilis. ( 27268292 )
2016

Variations for Syphilis

Copy number variations for Syphilis from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 111152 17 35097918 35138441 Copy number ERBB2 Syphilis

Expression for Syphilis

Search GEO for disease gene expression data for Syphilis.

Pathways for Syphilis

GO Terms for Syphilis

Cellular components related to Syphilis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.85 APOH B2M CAT CD209 FAS FN1
2 focal adhesion GO:0005925 9.67 B2M CAT MYH9 PPIB
3 cell surface GO:0009986 9.5 APOH B2M CD209 CD40LG FAS HLA-C
4 ER to Golgi transport vesicle membrane GO:0012507 9.43 B2M HLA-C HLA-DRB1
5 MHC class I protein complex GO:0042612 9.32 B2M HLA-C
6 external side of plasma membrane GO:0009897 9.1 B2M CD209 CD40LG CD79A FAS HLA-DRB1
7 membrane GO:0016020 10.18 B2M CAT CD209 CD40LG CD79A EXTL3

Biological processes related to Syphilis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.67 CD209 HLA-C HLA-DRB1 TPR
2 immune response GO:0006955 9.55 B2M CD40LG FAS HLA-C HLA-DRB1
3 interferon-gamma-mediated signaling pathway GO:0060333 9.43 B2M HLA-C HLA-DRB1
4 leukocyte cell-cell adhesion GO:0007159 9.4 CD209 CD40LG
5 immune system process GO:0002376 9.35 B2M CD209 CD79A HLA-C HLA-DRB1
6 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.32 B2M HLA-C
7 antigen processing and presentation GO:0019882 8.8 CD209 HLA-C HLA-DRB1

Molecular functions related to Syphilis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein anchor GO:0043495 8.96 MYH9 TPR
2 peptide antigen binding GO:0042605 8.8 CD209 HLA-C HLA-DRB1

Sources for Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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