MCID: SYP003
MIFTS: 56

Syphilis malady

Infectious diseases category

Summaries for Syphilis

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Syphilis is a sexually transmitted disease caused by bacteria. it infects the genital area, lips, mouth, or anus of both men and women. you usually get syphilis from sexual contact with someone who has it. it can also pass from mother to baby during pregnancy. the early stage of syphilis usually causes a single, small, painless sore. sometimes it causes swelling in nearby lymph nodes. if you do not treat it, syphilis usually causes a non-itchy skin rash, often on your hands and feet. many people do not notice symptoms for years. symptoms can go away and come back. the sores caused by syphilis make it easier to get or give someone hiv during sex. if you are pregnant, syphilis can cause birth defects, or you could lose your baby. in rare cases, syphilis causes serious health problems and even death. syphilis is easy to cure with antibiotics if you catch it early. correct usage of latex condoms greatly reduces, but does not completely eliminate, the risk of catching or spreading syphilis. nih: national institute of allergy and infectious diseases

MalaCards: Syphilis, also known as syphilis, unspecified, is related to primary syphilis and hepatitis. An important gene associated with Syphilis is CD40LG (CD40 ligand), and among its related pathways are Primary immunodeficiency and B cell receptor signaling pathway. The drug erythromycin pwdr and the compounds sulfolipid i and sandoglobulin have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and lymph node, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Disease Ontology:8 A primary bacterial infectious disease that is a sexually transmitted systemic disease, has material basis in treponema pallidum subsp pallidum, which is transmitted by sexual contact, transmitted by blood product transfusion, transmitted by congenital method from mother to fetus or transmitted by contact with infectious lesions. if left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

CDC:3 Syphilis is an STD that can have very serious complications when left untreated.

Wikipedia:63 Syphilis is a sexually transmitted infection caused by the spirochete bacterium Treponema pallidum... more...

Aliases & Classifications for Syphilis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 34MeSH, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

syphilis 8 10 44 33 60
syphilis, unspecified 8
syphilitic chancre 8
syphilis nos 8


External Ids:

Disease Ontology8 DOID:4166
MeSH34 D002601
ICD1025 A53.9

Related Diseases for Syphilis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Syphilis family:

Late Congenital Syphilis Early Congenital Syphilis
Primary Syphilis Congenital Syphilis

Diseases related to Syphilis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 272)
idRelated DiseaseScoreTop Affiliating Genes
1primary syphilis31.4ZBTB32, PDE6D
2hepatitis30.9CD40LG, ABCB7, CP
3hepatitis b30.6FN1, CD79A, ABCB7
4hepatitis c30.6CCR5, CD40LG, ABCB7
5nephrotic syndrome30.5CD79A
6uveitis30.4CCR5
7meningitis30.2CD79A
8toxoplasmosis30.2CD79A, CD40LG
9arthritis30.2CCR5, FN1
10tuberculosis30.2FN1, CD79A, CD209, CP
11herpes simplex30.2CD79A
12sarcoidosis30.2CCR5
13dermatitis30.2CD79A
14antiphospholipid syndrome30.2APOH, CD40LG, CD79A
15acquired immunodeficiency syndrome30.1CCR5
16rubella30.1CD79A, CD40LG
17vasculitis30.1APOH, FN1, CD40LG, CD79A
18systemic lupus erythematosus30.1CCR5, APOH, CD40LG, CD79A
19psoriasis30.1FN1
20malaria30.0CP
21hypertension30.0CD79A, FN1
22thrombocytopenia29.9ABCB7, CD79A, CD40LG, APOH
23q fever29.6CD79A
24leptospirosis29.6CD40LG, FN1
25viral hepatitis29.6ABCB7, FN1
26toxocariasis29.6TES
27infectious mononucleosis29.6CD40LG, CD79A
28behcet's disease29.6CCR5, APOH, CP
29inflammatory bowel disease29.6CD79A
30atherosclerosis29.6CCR5, APOH, FN1, CD40LG, CD209, CP
31rheumatoid arthritis29.6CCR5, APOH, FN1, CD40LG, CD79A, CP
32congenital syphilis11.2
33secondary syphilis11.1
34latent syphilis10.8
35cardiovascular syphilis10.8
36tertiary syphilis10.8
37early congenital syphilis10.6
38yaws10.6
39gonorrhea10.6
40late congenital syphilis10.5
41bejel10.4
42gummatous syphilis10.4
43interstitial keratitis10.3
44keratitis10.3
45lymphogranuloma venereum10.3
46glomerulonephritis10.3
47periostitis10.3
48tonsillitis10.2
49leprosy10.2
50choroiditis10.2

Graphical network of the top 20 diseases related to Syphilis:



Diseases related to syphilis

Clinical Features for Syphilis

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Drugs & Therapeutics for Syphilis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Syphilis

Drug clinical trials:

Search ClinicalTrials for Syphilis

Search NIH Clinical Center for Syphilis

Search CenterWatch for Syphilis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Syphilis

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Anatomical Context for Syphilis

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32MalaCards
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MalaCards organs/tissues related to Syphilis:

32
Testes, Skin, Lymph node, Bone, Liver, Tonsil, Tongue, Prostate, Eye, Spinal cord, Heart, T cells, Trachea, Placenta, Adrenal gland, Retina, Pituitary, Breast, Uterus, Spleen, Lung, Kidney, Brain, Temporal lobe

Animal Models for Syphilis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Syphilis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.2CCR5, ZBTB32, FN1, CD40LG, CD79A, IKBKG
2MP:00053768.8CCR5, CP, NLRP12, EXTL3, APOH, FN1
3MP:00053878.7CP, CD79A, CD40LG, FN1, CD209, ZBTB32
4MP:00107688.6PPIB, FEZF1, EXTL3, CCR5, APOH, ABCB7
5MP:00053848.5ABCB7, IKBKG, CD79A, CD40LG, FN1, ZBTB32

Publications for Syphilis

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Sources:
50PubMed
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Articles related to Syphilis:

(show top 50)    (show all 2001)
idTitleAuthorsYear
1
The prevalence of syphilis at childbirth in Ireland: a six-year review. (24354591)
2014
2
Polymerase chain reaction testing of vitreous in atypical ocular syphilis. (23617827)
2013
3
Ocular syphilis characterised by severe scleritis in a patient infected with HIV. (24156900)
2013
4
Is there a difference between hare syphilis and rabbit syphilis? Cross infection experiments between rabbits and hares. (23473645)
2013
5
Evaluation of harm reduction programs on seroincidence of HIV, hepatitis B and C, and syphilis among intravenous drug users in southwest China. (23486498)
2013
6
Characterizing the syphilis epidemic among men who have sex with men in Lima, Peru to identify new treatment and control strategies. (24016185)
2013
7
Prevalence and risk factors of syphilis infection among female sex workers in Shenzhen, China: an observational study (2009-2012). (24118535)
2013
8
Rapid plasma reagin titer variation in the 2 weeks after syphilis therapy. (22801348)
2012
9
An estimate of syphilis incidence in Eastern Europe. (23198131)
2012
10
Syphilis on the rise again in Germany--results from surveillance data for 2011. (22835467)
2012
11
Molecular subtyping of Treponema pallidum during a local syphilis epidemic in men who have sex with men in Melbourne, Australia. (22422857)
2012
12
Local transmission of imported endemic syphilis, Canada, 2011. (22607961)
2012
13
Perinatal outcome in cases of latent syphilis during pregnancy. (22503519)
2012
14
Demonstration of Treponema pallidum by immunohistochemistry in a patient with secondary syphilis mimicking pityriasis lichenoides chronica. (22142451)
2012
15
Prevalence of syphilis among antenatal clinic attendees in Karachi: imperative to begin universal screening in Pakistan. (22356034)
2011
16
Clinical aspects of congenital syphilis with Hutchinson's triad. (22670010)
2011
17
Tertiary syphilis mimicking hepatic metastases of underlying primary peritoneal serous carcinoma. (21161022)
2010
18
Occlusion of the left coronary trunk secondary to tertiary syphilis. (19851661)
2009
19
Decreases in AIDS mortality and increases in primary and secondary syphilis in men who have sex with men in the United States. (18223365)
2008
20
Destructive osteomyelitis associated with early secondary syphilis in an HIV-positive patient diagnosed by Treponema pallidum DNA polymerase chain reaction. (17461716)
2007
21
Is congenital syphilis really congenital syphilis? (17485812)
2006
22
Presternal indurated ulceration: primary syphilis. (16484829)
2006
23
Pustulocrustaceous secondary syphilis. (16191874)
2005
24
Cardiovascular syphilis in HIV infection: a case-control study at the Institute of Sexually Transmitted Diseases, Chennai, India. (16061553)
2005
25
Congenital syphilis: beta2-microglobulin in cerebrospinal fluid and diagnosis of neurosyphilis in an affected newborn. (15841621)
2005
26
Primary syphilis of oral mucosa: case report of an unusual manifestation. (15470997)
2004
27
Detection of treponema pallidum DNA in cutaneous lesions of secondary syphilis and characterization of the inflammatory infiltrate. (14601304)
2003
28
Activated and mature CD83-positive dendritic cells and interferon-gamma-positive cells in skin eruptions of secondary syphilis. (12816159)
2003
29
Unusual presentation of secondary syphilis in 2 HIV-1 positive patients. (11107526)
2000
30
Lichenoid secondary syphilis. (10065612)
1999
31
Congenital syphilis. (10063689)
1998
32
A nodule on the lip. Nodular secondary syphilis. (8678578)
1996
33
From the MMWR. Syphilis and congenital syphilis--United States, 1985-1988. (2844123)
1988
34
Comparative study of ceftriaxone and benzathine penicillin G in the treatment of primary and secondary syphilis. (3334620)
1987
35
Case of the month. Secondary syphilis. (6595306)
1984
36
Skeletal scintigraphy in congenital syphilis. (6653007)
1983
37
In situ identification of mononuclear cells in cutaneous infiltrates in discoid lupus erythematosus, sarcoidosis and secondary syphilis. (6172923)
1981
38
False-positive solubility--turbidity test for sickling hemoglobin in a case of congenital syphilis. (7353299)
1980
39
Congenital syphilis. (929438)
1977
40
A patient with primary syphilis of the hand. (606335)
1977
41
Malignant syphilis. Severe variant of secondary syphilis. (4592567)
1974
42
A graphic guide for clinical management of latent syphilis. (5427706)
1970
43
Secondary syphilis with unusual clinical and laboratory findings. (5763206)
1969
44
Early congenital syphilis and thrombocytopenia. (4171288)
1968
45
Serology in syphilis and yaws. (13307428)
1955
46
The modern treatment of cardiovascular syphilis. (14842305)
1951
47
The febrile Herxheimer reaction in early infectious and latent syphilis treated with penicillin. (14810450)
1950
48
Penicillin in cardiovascular syphilis; early reactions to administration. (20268440)
1947
49
Treatment of cardiovascular syphilis with penicillin. (20277501)
1946
50
Tertiary Syphilis of Unusually Extensive Distribution. (19973545)
1909

Genetic Variations for Syphilis

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Expression for genes affiliated with Syphilis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Syphilis

Search GEO for disease gene expression data for Syphilis.

Pathways for genes affiliated with Syphilis

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Syphilis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0IKBKG, CD79A, CD40LG
2
Hide members
9.9IKBKG, CD79A, CD40LG, CCR5

Compounds for genes affiliated with Syphilis

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Syphilis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1sulfolipid i4410.6CD79A, CD40LG
2sandoglobulin4410.6CD40LG, CD79A
3gluten4410.5CD79A, APOH
4uric acid44 2411.5ABCB7, APOH
5mannan4410.5CD209, CD79A, CD40LG
6pmma4410.5CD79A, CD40LG, FN1
7silicone4410.4FN1, CD40LG, CD79A
8cardiolipin44 1111.4CD79A, CD40LG, APOH
9vancomycin44 1111.4CD40LG, CD79A
10cytidine44 11 2412.4IKBKG, CD79A, CD40LG
11anti-fungal4410.4PPIB, CD40LG, CD79A
12phenytoin44 49 28 1113.4CD40LG, CD79A, CP
13rituximab44 49 1112.4APOH, CD40LG, CD79A
14ivig4410.4CD79A, CD40LG, APOH, CCR5
15dextran sulfate4410.4CCR5, APOH, FN1, CD40LG
16allergens4410.3CD209, CD79A, CD40LG
17cocaine44 1111.3CCR5, APOH, CD40LG, CD209
18pneumococcal4410.3CD40LG, CD79A
19betacarotene4410.3CP, CD79A, APOH
20vitamin b124410.3APOH, CD40LG, CD79A, CP
21mannose4410.3CCR5, APOH, CD79A, CD209
22polyethylene glycol4410.3CD79A, CD40LG, FN1
23sialic acid4410.3APOH, CD79A, ABCB7, CP
24blys4410.3CD40LG, CD79A
25thyroxine44 2411.3CD40LG, CD79A, ABCB7, CP
26folate4410.2APOH, CD40LG, CD79A, CP
27polyacrylamide4410.2CCR5, APOH, FN1, ABCB7
28aspirin44 49 28 2413.2CD79A, CD40LG, FN1, APOH
29hydroxychloroquine44 1111.2APOH, CD40LG
30vitamin-e4410.2CCR5, ABCB7, CP
31tuberculin4410.2CD79A, CD40LG
32polysaccharide4410.2CCR5, FN1, CD40LG, CD79A, CD209
33agar4410.2FN1, CD40LG, CD79A, CP
34galactose4410.1CD209, CD79A, APOH
35indomethacin44 59 28 1113.1FN1, CD40LG, CD79A, CP
36cyclosporin a44 28 5912.1CD79A, CD40LG, FN1, PPIB, CCR5
37vitamin d4410.0CP, CD79A, FN1, CCR5
38fibrinogen4410.0APOH, FN1, CD40LG, CD79A, ABCB7, CP
39lactate4410.0APOH, FN1, CD40LG, CD79A, ABCB7, CP
40creatinine4410.0APOH, FN1, CD40LG, CD79A, ABCB7, CP
41latex449.9FN1, APOH, CCR5
42dexamethasone44 49 28 1112.9CCR5, FN1, CD40LG, CD79A, CD209, CP
43alanine449.9CCR5, FN1, CD40LG, CD79A, ABCB7, CP
44zinc44 2410.9CCR5, APOH, ZBTB32, IKBKG, ABCB7, CP
45glutamate449.8CCR5, NLRP12, APOH, CD40LG, CD79A, ABCB7
46estrogen449.8CCR5, NLRP12, APOH, FN1, CD40LG, CD79A
47cysteine449.7CCR5, NLRP12, FN1, CD40LG, CD79A, CP
48biotin44 11 2411.7FN1, CD40LG, CD79A
49heparin44 28 11 2412.7CP, CCR5, APOH, PPIB, FN1, CD40LG
50arginine449.7CCR5, NLRP12, APOH, FN1, CD40LG, CD79A

GO Terms for genes affiliated with Syphilis

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16Gene Ontology
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Biological processes related to Syphilis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:04210010.2CD79A, CD40LG

Products for genes affiliated with Syphilis

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  • Antibodies
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  • Lysates
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Sources for Syphilis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet