MCID: SYP003
MIFTS: 51

Syphilis

Categories: Infectious diseases, Neuronal diseases, Bone diseases

Aliases & Classifications for Syphilis

MalaCards integrated aliases for Syphilis:

Name: Syphilis 12 52 41 3 14 69
Chancre 42 69
Syphilitic Chancre 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4166
ICD10 33 A51.0 A53.9
MeSH 42 D002601
SNOMED-CT 64 266127002 58433006
UMLS 69 C0007939

Summaries for Syphilis

MedlinePlus : 41 syphilis is a sexually transmitted disease caused by bacteria. it infects the genital area, lips, mouth, or anus of both men and women. you usually get syphilis from sexual contact with someone who has it. it can also pass from mother to baby during pregnancy. the early stage of syphilis usually causes a single, small, painless sore. sometimes it causes swelling in nearby lymph nodes. if you do not treat it, syphilis usually causes a non-itchy skin rash, often on your hands and feet. many people do not notice symptoms for years. symptoms can go away and come back. the sores caused by syphilis make it easier to get or give someone hiv during sex. if you are pregnant, syphilis can cause birth defects, or you could lose your baby. in rare cases, syphilis causes serious health problems and even death. syphilis is easy to cure with antibiotics if you catch it early. correct usage of latex condoms greatly reduces, but does not completely eliminate, the risk of catching or spreading syphilis. nih: national institute of allergy and infectious diseases

MalaCards based summary : Syphilis, also known as chancre, is related to rubella and lymphoma, and has symptoms including syphilitic chancre, fever and pelvic pain. An important gene associated with Syphilis is APOH (Apolipoprotein H), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Penicillin G and Procaine have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and heart, and related phenotypes are Increased shRNA abundance (Z-score > 2) and homeostasis/metabolism

Disease Ontology : 12 A primary bacterial infectious disease that is a sexually transmitted systemic disease, has material basis in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

CDC : 3 You should get tested regularly if you are pregnant, are a man who has sex with men, have HIV infection, and/or have partner(s) who have tested positive for syphilis.

Wikipedia : 72 Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies... more...

Related Diseases for Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 345)
id Related Disease Score Top Affiliating Genes
1 rubella 30.8 APOH CD40LG
2 lymphoma 30.6 APOH CD40LG CD79A
3 kaposi sarcoma 30.2 CD40LG CD79A HLA-DRB1
4 uveitis 30.2 CD40LG CD79A
5 chickenpox 30.1 APOH CD40LG CD79A
6 pulmonary hypertension 30.1 BCL2 FAS
7 membranoproliferative glomerulonephritis 29.9 CD40LG CD79A FAS
8 basilar artery occlusion 29.4 CD40LG CD79A EXTL3
9 congenital syphilis 12.4
10 tertiary syphilis 12.3
11 secondary syphilis 12.2
12 latent syphilis 12.2
13 primary syphilis 12.2
14 cardiovascular syphilis 12.2
15 late congenital syphilis 12.2
16 early congenital syphilis 12.1
17 gummatous syphilis 12.1
18 bejel 11.8
19 neurosyphilis 11.8
20 syphilitic aseptic meningitis 11.5
21 paroxysmal cold hemoglobinuria 11.2
22 tabes dorsalis 11.0
23 tertiary neurosyphilis 11.0
24 alcoholic neuropathy 10.9 CD40LG CD79A
25 calloso-genital dysplasia 10.9 CD40LG CD79A
26 variola major 10.9 CD40LG CD79A
27 mu chain disease 10.9 CD40LG CD79A
28 rabies 10.9 CD40LG CD79A
29 familial retinoblastoma 10.9 CD40LG CD79A
30 anti-basement membrane glomerulonephritis 10.9 CD40LG CD79A
31 microinvasive cervical squamous cell carcinoma 10.9 CD40LG CD79A
32 fetal erythroblastosis 10.8 CD40LG CD79A
33 spinal canal and spinal cord meningioma 10.8 CD40LG CD79A
34 trichostrongyloidiasis 10.8 CD40LG CD79A
35 retinal microaneurysm 10.8 CD40LG CD79A
36 heart septal defect 10.8 CD40LG CD79A
37 brown's tendon sheath syndrome 10.8 APOH CD40LG
38 acute kidney tubular necrosis 10.8 CD40LG CD79A
39 secretory meningioma 10.8 CD40LG CD79A
40 hodgkin's lymphoma, nodular sclerosis 10.8 CD40LG CD79A
41 imperforate oropharynx-costo vetebral anomalies 10.8 CD40LG CD79A
42 alcoholic gastritis 10.8 APOH CD40LG
43 malignant otitis externa 10.8 CD40LG CD79A
44 transient hypogammaglobulinemia 10.8 CD40LG CD79A
45 lockwood feingold syndrome 10.8 APOH CD40LG
46 benign epilepsy with centrotemporal spikes 10.8 CD40LG CD79A
47 tongue cancer 10.8 CD40LG CD79A
48 hydrops of gallbladder 10.8 CD40LG CD79A
49 gamma heavy chain disease 10.8 CD40LG CD79A
50 diabetic angiopathy 10.8 CD40LG CD79A

Comorbidity relations with Syphilis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Hypertension, Essential Schizophreniform Disorder

Graphical network of the top 20 diseases related to Syphilis:



Diseases related to Syphilis

Symptoms & Phenotypes for Syphilis

UMLS symptoms related to Syphilis:


syphilitic chancre, fever, pelvic pain, pruritus, gummatous inflammation

GenomeRNAi Phenotypes related to Syphilis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.78 CD209
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.78 CD209
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.78 NLRP12
4 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.78 HLA-DRB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.78 NLRP12
6 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.78 HLA-DRB1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.78 HLA-DRB1 NLRP12 CD209 FAS
8 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.78 FAS
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.78 HLA-DRB1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.78 HLA-DRB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.78 FAS HLA-DRB1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.78 CD209
13 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.78 FAS
14 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.78 HLA-DRB1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.78 FAS
16 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.78 FAS
17 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.78 CD209
18 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.78 CD209
19 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.78 CD209
20 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.78 NLRP12
21 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.78 CD209
22 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.78 NLRP12
23 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.78 NLRP12
24 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.78 HLA-DRB1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.78 CD209

MGI Mouse Phenotypes related to Syphilis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.32 APOH BCL2 CD40LG CD79A EXTL3 FAS

Drugs & Therapeutics for Syphilis

Drugs for Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 95)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin G Approved, Vet_approved Phase 4,Phase 3 61-33-6 5904
2
Procaine Approved, Investigational, Vet_approved Phase 4,Phase 3 59-46-1 4914
3
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Early Phase 1 564-25-0 54671203
4
Emtricitabine Approved, Investigational Phase 4,Phase 2 143491-57-0 60877
5 Anti-Bacterial Agents Phase 4,Phase 3,Early Phase 1
6 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
7 Penicillin G Benzathine Phase 4,Phase 3
8 Penicillin G Procaine Phase 4,Phase 3
9 penicillins Phase 4,Phase 3
10 Antimalarials Phase 4,Phase 3,Early Phase 1
11 Antiparasitic Agents Phase 4,Phase 3,Early Phase 1
12 Antiprotozoal Agents Phase 4,Phase 3,Early Phase 1
13 Anti-HIV Agents Phase 4,Phase 2
14 Anti-Retroviral Agents Phase 4,Phase 2
15 Antiviral Agents Phase 4,Phase 2
16 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3
17 Reverse Transcriptase Inhibitors Phase 4
18
Tenofovir Phase 4,Phase 2 147127-20-6 464205
19
Guaifenesin Approved, Vet_approved Phase 3 93-14-1 3516
20
Heroin Approved, Illicit Phase 3 561-27-3 5462328
21
Methadone Approved Phase 3 76-99-3 4095
22
Azithromycin Approved Phase 3 83905-01-5 55185 53477736 447043
23
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
24
Adalimumab Approved Phase 3 331731-18-1 16219006
25
Pyrimethamine Approved, Vet_approved Phase 3 58-14-0 4993
26
Sulfadoxine Approved Phase 3 2447-57-6 17134
27
chloroquine Approved, Vet_approved Phase 3 54-05-7 2719
28
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
29
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
30 Analgesics Phase 3
31 Analgesics, Opioid Phase 3
32 Antitussive Agents Phase 3
33 Central Nervous System Depressants Phase 3
34 Chlorpheniramine, phenylpropanolamine drug combination Phase 3
35 Narcotics Phase 3
36 Peripheral Nervous System Agents Phase 3,Phase 1,Phase 2
37 Respiratory System Agents Phase 3
38 Vaccines Phase 3,Phase 2
39 Antirheumatic Agents Phase 3
40 Anti-Inflammatory Agents Phase 3
41 Analgesics, Non-Narcotic Phase 3
42 Anti-Inflammatory Agents, Non-Steroidal Phase 3
43 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
44 mometasone furoate Phase 3 83919-23-7
45 Antimetabolites Phase 3
46 Antimetabolites, Antineoplastic Phase 3
47 Dermatologic Agents Phase 3
48 Folic Acid Antagonists Phase 3
49 Immunosuppressive Agents Phase 3
50 Vitamin B Complex Phase 3

Interventional clinical trials:

(show top 50) (show all 122)

id Name Status NCT ID Phase Drugs
1 Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
2 Serological Response to Retreatment of Serofast Early Syphilis Cases With Benzathine Penicillin Recruiting NCT02884115 Phase 4 benzathine penicillin
3 One Dose Versus Three Weekly Doses of Benzathine Penicillin G for Patients With Early Syphilis Recruiting NCT02857959 Phase 4 Benzathine Penicillin G
4 The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings Recruiting NCT02871505 Phase 4 Benzathine Penicillin G
5 Tenofovir/Emtricitabine With Doxycycline for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative MSM Not yet recruiting NCT02844634 Phase 4 Doxycycline 100mg PO daily x 12 months;Tenofovir/emtricitabine 200/300mg PO daily;Doxycycline 100mg PO daily x 6 months
6 PrEP Implementation for Mothers in Antenatal Care Not yet recruiting NCT03070600 Phase 4 Universal PrEP Counseling;Targeted PrEP Counseling
7 Introduction Study of Dual HIV & Syphilis Rapid Diagnostic Tests in Antenatal Clinics in Colombia Unknown status NCT02454816 Phase 2, Phase 3
8 (Men Who Have Sex With Men) MSM Community Intervention Trial Unknown status NCT01068015 Phase 3
9 Injecting Drug Use Community Intervention Trial Unknown status NCT01108614 Phase 3
10 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
11 Azithromycin/Bicillin Syphilis Completed NCT00031499 Phase 3 Azithromycin;Benzathine Penicillin;Doxycycline
12 Male Circumcision for HIV Prevention in Rakai, Uganda Completed NCT00425984 Phase 3
13 Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission Completed NCT00213083 Phase 3 Carraguard (PC-515)
14 Single-dose Azithromycin for the Treatment of Yaws Completed NCT01382004 Phase 3 Penicillin-G-benzathine;Azithromycin
15 Effectiveness of a Community-level HIV/STD Prevention Intervention in Promoting Safer Sexual Behaviors in High-risk Populations Completed NCT00710060 Phase 3
16 MEMA Kwa Vijana Trial: Impact of an Adolescent Sexual and Reproductive Health Intervention in Mwanza, Tanzania Completed NCT00248469 Phase 3
17 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
18 Expanded PrEP Implementation in Communities in NSW Recruiting NCT02870790 Phase 3 TDF/FTC
19 Protecting From Pneumococcus in Early Life (The PROPEL Trial) Recruiting NCT02628886 Phase 3
20 Evaluation of the Effectiveness and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo, in Subjects With Rheumatoid Arthritis (RA) Who Are Taking an Existing Medication Called a Tumour Necrosis Factor Alpha Inhibitor But Have Active Di Recruiting NCT02760433 Phase 3 Olokizumab q4w;Olokizumab q2w;Placebo q2w
21 Evaluation of the Long Term Safety, Tolerability and Efficacy of Two Dosing Regimens of Olokizumab (OKZ), in Subjects With Rheumatoid Arthritis (RA) Who Previously Completed 24 Weeks of Blinded Treatment in One of the Core Studies - CREDO 1, 2 or 3. Recruiting NCT03120949 Phase 3 Olokizumab 64 mg SC q4w;Olokizumab 64 mg SC q2w;Methotrexate
22 Evaluation of the Effectiveness and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo and Adalimumab, in Subjects With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate But Have Active Disease Recruiting NCT02760407 Phase 3 Olokizumab 64mg q4w;Olokizumab 64mg q2w;Adalimumab 40mg q2w;Placebo q2w
23 Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy Recruiting NCT01901094 Phase 3
24 Improving PRegnancy Outcomes With Intermittent preVEntive Treatment in Africa Not yet recruiting NCT03208179 Phase 3 dihydroartemisinin-piperaquine;sulphadoxine-pyrimethamine;dihydroartemisinin-piperaquine plus azithromycin
25 Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa Terminated NCT01103063 Phase 3 Azithromycin plus chloroquine;sulfadoxine-pyrimethamine
26 Effectiveness of the Diaphragm for HIV Prevention Withdrawn NCT00121459 Phase 3
27 Safety, Acceptability and Preliminary Effectiveness of Carraguard™ (PC-515) in Preventing HIV/STI Transmission Completed NCT00213018 Phase 2 Carraguard (PC-515)
28 Safety, Acceptability and Preliminary Effectiveness of PC-515 for Vaginal Use as a Possible Microbicide Completed NCT00213031 Phase 2 Carraguard (PC-515)
29 Behavioral Intervention to Reduce Sexual and Injection Risks Among Female Sex Workers Who Also Inject Drugs in Mexico Completed NCT00840658 Phase 2
30 A Web-based Intervention Study to Reduce High-risk Sexual Behavior by Persons Living With HIV AIDS (PLWH) Completed NCT01198418 Phase 1, Phase 2
31 Lay Health Advisors for Sexually Transmitted Disease Prevention Completed NCT00207506 Phase 1, Phase 2
32 Safety and Efficacy Study of Human Autologous Hair Follicle Cells to Treat Androgenetic Alopecia Completed NCT01286649 Phase 1, Phase 2
33 Development of a Methamphetamine Early Intervention Completed NCT01174654 Phase 1, Phase 2
34 A Tolerability and Efficacy Study of TU-100 For The Treatment of Postoperative Ileus Completed NCT00266461 Phase 2 Daikenchuto Extract Granules (TU-100)
35 BufferGel and PRO 2000/5: Vaginal Gels to Prevent HIV Infection in Women Completed NCT00074425 Phase 2 BufferGel;PRO 2000/5 Gel;Placebo gel
36 Safer Sex Program for Young African-American Men Recruiting NCT01439503 Phase 2
37 An Investigational Study to Evaluate BMS-986165 in Patients With Systemic Lupus Erythematosus Recruiting NCT03252587 Phase 2 BMS-986165
38 Optimizing the Delivery of HIV nPEP Not yet recruiting NCT03259698 Phase 2 nPEP
39 Development of Immune Globulin Treatment for Avian Flu Terminated NCT00383071 Phase 2
40 Infections and Autoimmunity: Autobodies Screening in Multiple Sclerosis Unknown status NCT00230204 Phase 1
41 Computer-Assisted Tailored Cue-card Health [CATCH] Study Completed NCT01170741 Phase 1
42 Safety and Acceptability of Carraguard™ Among HIV-negative Couples in Thailand Completed NCT00213057 Phase 1 Carraguard (PC-515)
43 Fecal Microbiota Transplantation in Pediatric Patients Completed NCT02108821 Phase 1
44 Syphilis Treatment of Partners Trial Unknown status NCT02262390
45 A Methadone Maintenance Treatment Outcome Study in Three Provinces in China Unknown status NCT01315054
46 Human Papillomavirus Infection and Knowledge and Attitudes About HPV Vaccines Among Men Who Have Sex With Men (MSM) Unknown status NCT01300689
47 The Impact of Short-term Financial Incentives on Sexual Behavior and HIV Incidence in Lesotho Unknown status NCT01589965 Early Phase 1
48 Illness Crisis Adapting in Early or Middle Phase of Patient With Chronic Disease: Study of Meta-cognition Model Unknown status NCT01964612
49 Evaluation of Therapeutic Management in ESBL-infected Patients or Carriers by Providing and Sharing a Free Tool - the "ESBL toolKIT"and Interventional Study of a Prospective Cohort of HIV+ Patients Searching for Possible Sexual Transmission Factors in ESB Unknown status NCT02011009
50 Preparing for Adolescent HIV Vaccine Trials in South Africa: Unknown status NCT00944879

Search NIH Clinical Center for Syphilis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: chancre

Genetic Tests for Syphilis

Anatomical Context for Syphilis

MalaCards organs/tissues related to Syphilis:

39
Testes, Skin, Heart, Lymph Node, Bone, Liver, Tonsil

Publications for Syphilis

Articles related to Syphilis:

(show top 50) (show all 2334)
id Title Authors Year
1
Psoriasiform papules, condyloma lata, lung nodules and hepatitis: the enormous variability of secondary syphilis manifestations. ( 28476906 )
2017
2
New imaging tools for an old disease: Secondary syphilis. ( 28718501 )
2017
3
Investigation of Early Syphilis Trends Among Men Who Have Sex With Men to Identify Gaps in Screening and Case-Finding in Baltimore City, Maryland. ( 28876286 )
2017
4
Dorsal longitudinal foreskin cut is associated with reduced risk of HIV, syphilis and genital herpes in men: a cross-sectional study in Papua New Guinea. ( 28406272 )
2017
5
Syphilis in Pregnancy and Congenital Syphilis: Reality in a Portuguese Central University Hospital. ( 28609805 )
2017
6
What Is the Role of Paired Rapid Plasma Reagin Testing (Simultaneous Testing of Acute and Convalescent Samples) in the Diagnosis of Repeat Syphilis and the Follow-up of Syphilis? ( 28876300 )
2017
7
Secondary syphilis mimicking malignancy: A case report and review of literature. ( 28456488 )
2017
8
Knowledge, behaviors, and attitudes of HIV-infected men about syphilis. ( 28943166 )
2017
9
Congenital Syphilis: Time for a National Prevention Program. ( 28703732 )
2017
10
Late Neurosyphilis and Tertiary Syphilis in Guangdong Province, China: Results from a Cross-sectional Study. ( 28338084 )
2017
11
Transient aortitis documented by positron emission tomography in a case series of men and transgender women infected with syphilis. ( 28866636 )
2017
12
Secondary syphilis primarily presenting with multiple nodules on the scalp: Case report and published work review. ( 28714113 )
2017
13
Diagnostic and Therapeutic Knowledge and Practices in the Management of Congenital Syphilis by Pediatricians in Public Maternity Hospitals in Brazil. ( 28735562 )
2017
14
Factors associated with syphilis treatment failure and reinfection: a longitudinal cohort study in Shenzhen, China. ( 28903736 )
2017
15
Secondary syphilis: An unusual presentation. ( 28442816 )
2017
16
Tracing partners of patients with syphilis infection remains challenging: experience of Geneva Hospital. ( 28081685 )
2017
17
Primary syphilis in a secondary stage. ( 28755824 )
2017
18
The return of a former foe: syphilis with antiphospholipid syndrome as a cause of acute stroke. ( 28904807 )
2017
19
Provider Adherence to Syphilis Testing Recommendations for Women Delivering a Stillbirth. ( 28876321 )
2017
20
Congenital Syphilis of Bone: A Potential Mimicker of Childhood Histiocytoses. ( 28614210 )
2017
21
Congenital syphilis. ( 28626975 )
2017
22
Pityriasis rosea in a patient with retrovirus infection and a history of syphilis and positive results of infection with hepatitis A virus, hepatitis B virus and hepatitis C virus. ( 28670260 )
2017
23
Congenital Syphilis Masquerading as Leukemia. ( 28845335 )
2017
24
Fetal response to intramuscular epinephrine for anaphylaxis during maternal penicillin desensitization for secondary syphilis. ( 28562129 )
2017
25
Papulonodular Secondary Syphilis Presenting as Multiple Distinct Cutaneous Lesions in an HIV-Positive Transgender Woman. ( 28512403 )
2017
26
Secondary syphilis-related oral mucous patches. ( 28593145 )
2017
27
The Annual Economic Burden of Syphilis: An Estimation of Direct, Productivity, and Intangible Costs for Syphilis in Guangdong Initiative for Comprehensive Control of Syphilis Sites. ( 28876318 )
2017
28
Kissing chancre of primary syphilis. ( 28070492 )
2017
29
Screening for Syphilis Infection in Nonpregnant Adults and Adolescents. ( 28925643 )
2017
30
Cytokine Profiles in Aqueous Humor and Plasma of HIV-infected Individuals with Ocular Syphilis or Cytomegalovirus Retinitis. ( 28081374 )
2017
31
Ocular involvement with secondary syphilis in a non-HIV infected man. ( 28840111 )
2017
32
Secondary syphilis. ( 28696198 )
2017
33
Screening for asymptomatic neurosyphilis in HIV patients after treatment of early syphilis: an observational study. ( 28196838 )
2017
34
The Diagnosis of Secondary Syphilis by Gram and Giemsa Staining. ( 28768989 )
2017
35
Reported Cases of Neurosyphilis Among Early Syphilis Cases-United States, 2009 to 2015. ( 28876294 )
2017
36
Sensitivity of nPCR for four types of membrane protein DNA and of two pairs of primers for Tpp47 DNA of Treponema pallidum in whole blood of congenital syphilis newborns. ( 28889773 )
2017
37
Secondary Syphilis Presenting as Glossodynia, Plaques en Prairie FauchAce, and a Split Papule at the Oral Commissure: Case Report and Review. ( 28785283 )
2017
38
Pulmonary involvement of secondary syphilis. ( 28661232 )
2017
39
Congenital syphilis in neonates with nonreactive nontreponemal test results. ( 28682315 )
2017
40
Effects on preventing mother-to-child transmission of syphilis and associated adverse pregnant outcomes: a longitudinal study from 2001 to 2015 in Shanghai, China. ( 28923018 )
2017
41
Secondary syphilis infection under treatment with ustekinumab. ( 28866870 )
2017
42
Pseudoparalysis of Parrot: A Diagnostic Aid in Congenital Syphilis. ( 28918883 )
2017
43
Dental Traits of Congenital Syphilis Revisited in Dental Outpatient Department (OPD). ( 28342059 )
2017
44
Unique manifestations and risk factors of Jarisch-Herxheimer reaction during treatment of child congenital syphilis. ( 28942420 )
2017
45
Anetoderma due to secondary syphilis: Report of two cases and discussion of the histopathological findings. ( 28571518 )
2017
46
Alopecia as unique clue to syphilis in a patient. ( 28906089 )
2017
47
Brief report: Use of ICD-10 code A51.31 (condyloma latum) for identifying cases of secondary syphilis. ( 28953413 )
2017
48
A pseudotumoral facial mass revealing tertiary syphilis. ( 28543323 )
2017
49
Secondary syphilis: The great imitator can't be forgotten. ( 28876421 )
2017
50
Serum microRNA profiles in patients with syphilis. ( 28079920 )
2017

Variations for Syphilis

Copy number variations for Syphilis from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 111152 17 35097918 35138441 Copy number ERBB2 Syphilis

Expression for Syphilis

Search GEO for disease gene expression data for Syphilis.

Pathways for Syphilis

Pathways related to Syphilis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 BCL2 CD209 CD40LG CD79A FN1 HLA-C
2
Show member pathways
12.21 BCL2 CD40LG FN1 HLA-C HLA-DRB1 TPR
3 12.05 BCL2 FAS FN1 TPR
4 11.73 CD209 HLA-C HLA-DRB1
5 11.59 CD40LG HLA-C HLA-DRB1
6 10.23 BCL2 FN1

GO Terms for Syphilis

Cellular components related to Syphilis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.76 APOH CD209 FAS FN1 HLA-C HLA-DRB1
2 cell surface GO:0009986 9.43 APOH CD209 CD40LG FAS HLA-C HLA-DRB1
3 external side of plasma membrane GO:0009897 9.02 CD209 CD40LG CD79A FAS HLA-DRB1

Biological processes related to Syphilis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 9.43 BCL2 CD40LG CD79A
2 renal system process GO:0003014 9.32 BCL2 FAS
3 negative regulation of myeloid cell apoptotic process GO:0033033 9.16 APOH BCL2
4 antigen processing and presentation GO:0019882 9.13 CD209 HLA-C HLA-DRB1
5 B cell proliferation GO:0042100 8.8 BCL2 CD40LG CD79A

Molecular functions related to Syphilis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein anchor GO:0043495 8.96 MYH9 TPR
2 peptide antigen binding GO:0042605 8.8 CD209 HLA-C HLA-DRB1

Sources for Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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