Summaries for Syphilis

Sources:
6Disease Ontology, 23MedlinePlus, 2CDC, 44Wikipedia, 22MalaCards
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MedlinePlus: Syphilis is a sexually transmitted disease caused by bacteria. it infects the genital area, lips, mouth, or anus of both men and women. you usually get syphilis from sexual contact with someone who has it. it can also pass from mother to baby during pregnancy. the early stage of syphilis usually causes a single, small, painless sore. sometimes it causes swelling in nearby lymph nodes. if you do not treat it, syphilis usually causes a non-itchy skin rash, often on your hands and feet. many people do not notice symptoms for years. symptoms can go away and come back. the sores caused by syphilis make it easier to get or give someone hiv during sex. if you are pregnant, syphilis can cause birth defects, or you could lose your baby. in rare cases, syphilis causes serious health problems and even death. syphilis is easy to cure with antibiotics if you catch it early. correct usage of latex condoms greatly reduces, but does not completely eliminate, the risk of catching or spreading syphilis. nih: national institute of allergy and infectious diseases23

MalaCards: Syphilis, also known as syphilis, unspecified (disorder), is related to congenital syphilis and primary syphilis. An important gene associated with Syphilis is CD40LG (CD40 ligand), and among its related pathways are Immune response NFAT in immune response and Primary immunodeficiency. The drugs erythromycin and oxytetracycline and the compounds ivig and rituximab have been mentioned in the context of this disorder. Affiliated tissues include lymph node and skin, and related mouse phenotypes are cellular and homeostasis/metabolism.

Disease Ontology: A primary bacterial infectious disease that is a sexually transmitted systemic disease, has material basis in treponema pallidum subsp pallidum, which is transmitted by sexual contact, transmitted by blood product transfusion, transmitted by congenital method from mother to fetus or transmitted by contact with infectious lesions. if left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.6

CDC: The sexual behaviors that spread syphilis also spread other STDs, like HIV.2

Wikipedia: Syphilis is a sexually transmitted infection caused by the spirochete bacterium Treponema pallidum...44 more...

Aliases & Descriptions for Syphilis

Sources:
2CDC, 6Disease Ontology, 8DISEASES, 32Novoseek , 23MedlinePlus, 43UMLS, 40SNOMED-CT, 24MeSH
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Aliases & Descriptions:

syphilis 6 8 32 23 43
syphilis, unspecified (disorder) 6
syphilis nos (disorder) 6
syphilis, unspecified 6
syphilis (disorder) 6
syphilitic chancre 6
syphilis nos 6
chancre 43

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Related Diseases for Syphilis

Sources:
13GeneCards, 14GeneDecks
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Diseases related to syphilis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 361)
idRelated DiseaseScoreTop Affiliating Genes
1congenital syphilis33.3CD40LG, IKBKG, ABCB7, STIL
2primary syphilis33.0ZBTB32, PDE6D
3secondary syphilis31.8CD209, CD79A, CD40LG, FN1, CCR5, PDE6D
4latent syphilis31.1FEZF1, FEZF2, PDE6D
5antiphospholipid syndrome30.4APOH, F2
6leptospirosis25.5CD79A, CD40LG, FN1, APOH, F2, HLA-DRB1
7systemic lupus erythematosus25.4B2M, CD79A, CD40LG, APOH, ANXA5, CCR5
8lupus erythematosus25.4B2M, CD79A, CD40LG, APOH, ANXA5, CCR5
9malaria22.4B2M, CD40LG, APOH, ANXA5, CCR5, IGHE
10cd40 ligand deficiency13.6CD79A, CD40LG
11congenital toxoplasmosis13.6CD79A, CD40LG
12transverse myelitis13.6CD40LG, APOH
13selective iga deficiency disease13.6CD79A, CD40LG
14sporotrichosis13.6CD79A, CD40LG
15breast metaplastic carcinoma13.6FEZF1, FEZF2
16immunodeficiency, centromere instability and facial anomalies syndrome13.5CD79A, CD40LG
17cryofibrinogenemia13.5CD79A, CD40LG, FN1
18central nervous system disease13.5CD40LG, APOH, CCR5
19dandy-walker syndrome13.5CD79A, CD40LG
20autoimmune disease of central nervous system13.5CD79A, CD40LG
21dengue disease13.5CD209, CD40LG, ABCB7
22collagenous colitis13.5CD79A, CD40LG, APOH
23calciphylaxis13.5CD79A, CD40LG, FN1
24uterine inversion13.5FEZF1, FEZF2
25mesangial proliferative glomerulonephritis13.5CD79A, FN1
26hematuria13.4CD79A, CD40LG, FN1
27iritis13.4CD79A, CD40LG
28lymph node tuberculosis13.4FEZF1, FEZF2
29brucellosis13.4CD79A, CD40LG, CCR5
30agammaglobulinemia13.3CD79A, CD40LG, ABCB7
31iga glomerulonephritis13.3CD79A, CD40LG, FN1, CCR5
32al amyloidosis13.3B2M, CD79A, CD40LG
33meningoencephalitis13.3B2M, CD79A, CD40LG
34exercise induced anaphylaxis13.3CD79A, IGHE
35chronic rapidly progressive glomerulonephritis13.3B2M, CD79A, FN1
36monoclonal gammopathy of undetermined significance13.3B2M, CD79A, CD40LG
37behcet's disease13.2APOH, CCR5, CP
38toxocariasis13.2CD40LG, IGHE
39polyradiculoneuropathy13.2CD40LG, CCR5, HLA-DRB1
40immunodeficiency with hyper igm13.2CD79A, CD40LG, IGHE
41nervous system disease13.2B2M, CD40LG, APOH, CCR5
42immunoglobulin alpha deficiency13.2CD79A, CD40LG, IGHE
43immunodeficiency with hyper igm type 113.2CD79A, CD40LG, IGHE
44posterior uveitis13.2CD79A, CD40LG, IGHE
45histoplasmosis13.1CD79A, CD40LG, HLA-DRB1
46polymyalgia rheumatica13.1APOH, CCR5, HLA-DRB1
47herpes zoster13.1CD79A, CCR5, HLA-DRB1
48pemphigus foliaceus13.1CD79A, CD40LG, HLA-DRB1
49spondyloarthropathy13.1B2M, CD79A, CD40LG, FN1
50clostridium difficile13.1LACTB, CD79A, CD40LG

Graphical network of the top 20 diseases related to syphilis:



Graphical network of diseases related to syphilis

Clinical Features for Syphilis

Drugs & Therapeutics for Syphilis

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Genetic Tests for Syphilis

Anatomical Context for Syphilis

Sources:
22MalaCards
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MalaCards organs/tissues related to syphilis:

22
Lymph node, Skin

Phenotypes for genes affiliated with Syphilis

Sources:
25MGI
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MGI Mouse Phenotypes related to syphilis:

25
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1cellular phenotypeMP:0005384INF, MYH9, CP, STIL, ABCB7, NLRP12
2homeostasis/metabolism phenotypeMP:00053766.0MYH9, CP, ABCB7, NLRP12, F2, IGHE
3nervous system phenotypeMP:0003631INFF2, ABCB7, STIL, CP, MYH9, CCR5
4immune system phenotypeMP:0005387INFMYH9, NLRP12, F2, IKBKG, FN1, CD79A
5hematopoietic system phenotypeMP:0005397INFMYH9, NLRP12, IGHE, IKBKG,
6mortality/agingMP:0010768INFIKBKG, F2, PPIB, ABCB7, STIL, CCR5

Publications for genes affiliated with Syphilis

Sources:
35PubMed
See all sources

Articles related to syphilis:

(show all 28)
idTitleAuthorsYearAffiliating Genes
1Association of the HLA-DRB1 locus with syphilis in a Chinese population. (21411354)Jiang H.W.... Zhang F.R.2011HLA-DRB1
2Time course of changes in lipid peroxidation parameters in patients with syphilis (19253693)Nagoev B.S.... Bzhakhova F.K.2009CP
3Treponema pallidum elicits innate and adaptive cellular immune responses in skin and blood during secondary syphilis: a flow-cytometric analysis. (17299719)Salazar J.C.... Radolf J.D.2007CCR5, CD209
4Intrathecal antitreponemal antibody synthesis determination using the INNO-LIA Syphilis Score. (18204743)Kotnik V.... Potocnik M.2007APOH
5Resistance to annexin A5 binding and anticoagulant activity in plasmas from patients with the antiphospholipid syndrome but not with syphilis. (16409485)Wu X.X.... Rand J.H.2006ANXA5
6A novel beta-lactamase activity from a penicillin-binding protein of Treponema pallidum and why syphilis is still treatable with penicillin. (14747460)Cha J.Y.... Mobashery S.2004LACTB
7Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar. (11491498)Santiago M.... Gharavi A.2001APOH
8Different types of antiphospholipid antibodies in AIDS: a comparison with syphilis and the antiphospholipid syndrome. (10554081)de LarraA+aga G.F.... Alonso B.S.1999F2, APOH
9Vitritis as the primary manifestation of ocular syphilis in patients with HIV infection. (9512147)Kuo I.C.... Rao N.A.1998CD40LG
10Nucleotide sequences of the proA and proB genes of Treponema pallidum, the syphilis agent. (9522123)Stamm L.V.... Barnes N.Y.1997PROA
11Identification of homologs for thioredoxin, peptidyl prolyl cis-trans isomerase, and glycerophosphodiester phosphodiesterase in outer membrane fractions from Treponema pallidum, the syphilis spirochete. (9317025)Shevchenko D.V.... Radolf J.D.1997PPIB
12Molecular characterization and cellular localization of TpLRR, a processed leucine-rich repeat protein of Treponema pallidum, the syphilis spirochete. (9150213)Shevchenko D.V.... Radolf J.D.1997NLRP12
13Immune stimulation by syphilis and malaria in HIV-2-infected and uninfected villagers in West Africa. (9624734)N'Gom P.T.... Whittle H.C.1997B2M
14Reactivity to beta 2 glycoprotein I clearly differentiates anticardiolipin antibodies from antiphospholipid syndrome and syphilis. (8725711)Forastiero R.R.... Carreras L.O.1996APOH
15Anticardiolipin antibodies from syphilis and systemic lupus erythematosus induce leakage in cardiolipin vesicles. (8736113)GremiALo M.P.... Chaimovich H.1996APOH
16Comparison of the effects of anticardiolipin antibodies from patients with the antiphospholipid syndrome and with syphilis on platelet activation and aggregation. (7667838)Campbell A.L.... Harris E.N.1995APOH
17Detection of beta-2-glycoprotein-I-dependent antiphospholipid antibodies and anti-beta-2-glycoprotein-I antibody in patients with systemic lupus erythematosus and in patients with syphilis. (8111242)Matsuda J.... Tsukamoto M.1994APOH
18Differences in functional activity of anticardiolipin antibodies from patients with syphilis and those with antiphospholipid syndrom e. (8063429)Pierangeli S.S.... Harris E.N.1994APOH
19Laboratory diagnosis of congenital syphilis by immunoglobulin M (IgM) and IgA immunoblotting. (7496918)Schmitz J.L.... Folds J.D.1994CD40LG
20Distinguishing beta 2-glycoprotein I dependent (systemic lupus erythematosus type) and independent (syphilis type) anticardiolipin antibody with Tween 20. (7918046)Matsuda J.... Tsukamoto M.1993APOH
21Changes in circulating immune complexes during the Ja risch Herxheimer reaction in secondary syphilis. (8508816)Loveday C.... Bingham J.S.1993CD40LG, CD79A
22IgM rheumatoid factor removal and performance of the FTA-ABS (IgM) test in congenital syphilis. (1398661)Meyer M.P.... Louw S.1992CD40LG
23Presence of IgE class antibodies with cardiolipinic and treponemal specificity in syphilis. Quantitative evaluation by IgE prist radio-immuno-assay. (1457821)Ionescu A.D.... Ivanescu M.1992IGHE
24Congenital syphilis (1305279)Kurzke C.... Blatz R.1992ABCB7
25Specific serologic reactions in the cerebrospinal fluid in congenital syphilis and therapeutic implications (2256636)Gendrel D.... Nguemby-Mbina C.1990CD40LG
26Antiphospholipid antibodies in syphilis. (2095288)Santiago M.B.... de-Oliveira R.M.1990APOH
27Evaluation of immunoglobulin M western blot analysis in the diagnosis of congenital syphilis. (2179261)Lewis L.L.... Baughn R.E.1990CD40LG
28Immunoglobulin class and subclass restriction of auto immune responses in secondary syphilis. (2372987)Versalovic J.... Baughn R.E.1990FN1

Expression for genes affiliated with Syphilis

Sources:
1BioGPS
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Expression patterns in normal tissues for genes affiliated with Syphilis

Pathways for genes affiliated with Syphilis

Sources:
10EMD Millipore, 20KEGG, 41Thomson Reuters
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Pathways related to syphilis according to GeneDecks:

idPathwayScoreTop Affiliating Genes
1Immune response NFAT in immune response109.9CD79A, IKBKG
2Primary immunodeficiency209.9IKBKG
3Immune response_NFAT in immune response419.5IKBKG, IGHE
4Toxoplasmosis209.0CD40LG, CCR5, IKBKG, HLA-DRB1

Compounds for genes affiliated with Syphilis

Sources:
32Novoseek , 34PharmGKB, 9DrugBank, 18HMDB, 42Tocris Bioscience
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Compounds related to syphilis according to GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1ivig32 10.7CCR5
2rituximab32 34 9 9 13.4CD79A, CD40LG
3polyethylene glycol32 10.3FN1
4sulfolipid i32 10.2CD40LG, CD79A
5gamma globulin32 10.2B2M, CD79A
6vancomycin32 9 9 12.1LACTB, CD79A, CD40LG
7dextran sulfate32 10.1APOH, CCR5, FN1, CD40LG
8phosphatidylserine32 9 9 12.0F2, CD79A
9praziquantel32 9 9 11.9CD40LG, IGHE, CD79A
10pmma32 9.9FN1, CD79A, B2M, CD40LG
11carbohydrates32 9.8CP, CD209, ANXA5
12gliadin32 9.8CD79A, IGHE, CD40LG
13vegf32 9.8CP, APOH, FN1, CD40LG
14silicone32 9.7IGHE, CD79A, CD40LG, FN1
15sulfamethoxazole32 9 9 11.7CD40LG, LACTB, IGHE
16tirofiban32 9 9 11.7ANXA5, CD40LG, F2
17azithromycin32 9 9 11.7F2, CD79A, LACTB
18hyaluronic acid32 18 10.7F2, B2M, FN1
19agar32 9.6CD40LG, FN1, LACTB
20pge132 9.6B2M, APOH, IGHE
21aspartate32 9.6ABCB7, B2M, F2, CD40LG
22betacarotene32 9.5CD79A, CP, APOH, ANXA5
23clarithromycin32 9 9 11.5LACTB, CD79A, F2
24vitamin b1232 9.4CD79A, B2M, CD40LG, CP, APOH
25cardiolipin32 9 9 11.4ANXA5, APOH, CD79A, CD40LG, F2
26aspirin32 34 18 11.4APOH, F2, CD79A, CD40LG, FN1
27uric acid32 18 10.4ABCB7, B2M, CP, APOH
28penicillin32 9.3LACTB, CD79A, IGHE, F2
29vitamin-e32 9.2CCR5, ABCB7, B2M, CP
30phosphatidylcholine32 9.2F2, ANXA5, APOH, FN1, CD79A
31galactose32 9.1B2M, CD79A, CD209, APOH
32polysaccharide32 9.0FN1, IGHE, CD209, CCR5, CD40LG, CD79A
33allergens32 8.9CD209, CD40LG, IGHE, HLA-DRB1, CD79A
34acetaminophen32 34 9 18 9 12.9IGHE, B2M, F2, ANXA5
35thyroxine32 18 9.9ABCB7, CP, CD79A, CD40LG, B2M, IGHE
36estrogen32 8.9CP, IGHE, APOH, F2, NLRP12
37folate32 8.9CD79A, CD40LG, APOH, IGHE, CP, B2M
38vitamin d32 8.8CCR5, CD79A, CP, B2M, FN1, IGHE
39heparin32 9 18 9 11.7PPIB, ABCB7, F2, CD79A, FN1, CP
40fibrinogen32 8.5F2, CD79A, CD40LG, FN1, ANXA5, APOH
41indomethacin32 9 9 10.5CD79A, CP, IGHE, ANXA5, B2M, CD40LG
42dexamethasone32 42 34 9 9 12.5IGHE, CCR5, ANXA5, CD79A, CP, FN1
43methotrexate32 34 42 9 9 12.4CD79A, APOH, HLA-DRB1, F2, IGHE
44cyclosporin a32 42 9.0PPIB, F2, CCR5, IGHE, ANXA5, FN1
45creatinine32 8.0FN1, CD40LG, CD79A, IGHE, F2, ABCB7
46retinoic acid32 42 18 9.9B2M, CD79A, CD40LG, FN1, CCR5, IGHE
47lactate32 7.6CD40LG, FN1, ANXA5, IGHE, F2, ABCB7
48arginine32 7.5CP, NLRP12, FN1, HLA-DRB1, IGHE, IKBKG
49glutamate32 7.5APOH, ANXA5, CD40LG, IGHE, HLA-DRB1, NLRP12
50alanine32 7.2ABCB7, IGHE, F2, HLA-DRB1, CCR5, CP

GO Terms for genes affiliated with Syphilis

Sources:
12Gene Ontology
See all sources

Cellular components related to syphilis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.3B2M, CD79A, CD40LG, ANXA5, CCR5, HLA-DRB1

Biological processes related to syphilis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1forebrain anterior/posterior pattern specificationGO:021797INFFEZF1,

Sources for Syphilis

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS