MCID: SYP003
MIFTS: 53

Syphilis malady

Categories: Infectious diseases, Neuronal diseases, Bone diseases

Aliases & Classifications for Syphilis

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Summaries for Syphilis

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MedlinePlus:38 Syphilis is a sexually transmitted disease caused by bacteria. it infects the genital area, lips, mouth, or anus of both men and women. you usually get syphilis from sexual contact with someone who has it. it can also pass from mother to baby during pregnancy. the early stage of syphilis usually causes a single, small, painless sore. sometimes it causes swelling in nearby lymph nodes. if you do not treat it, syphilis usually causes a non-itchy skin rash, often on your hands and feet. many people do not notice symptoms for years. symptoms can go away and come back. the sores caused by syphilis make it easier to get or give someone hiv during sex. if you are pregnant, syphilis can cause birth defects, or you could lose your baby. in rare cases, syphilis causes serious health problems and even death. syphilis is easy to cure with antibiotics if you catch it early. correct usage of latex condoms greatly reduces, but does not completely eliminate, the risk of catching or spreading syphilis. nih: national institute of allergy and infectious diseases

MalaCards based summary: Syphilis, also known as chancre, is related to basilar artery occlusion and early yaws, and has symptoms including syphilitic chancre, fever and pelvic pain. An important gene associated with Syphilis is APOH (Apolipoprotein H), and among its related pathways are Antigen Presentation- Folding, assembly and peptide loading of class I MHC and Cell adhesion molecules (CAMs). The drug erythromycin pwdr has been mentioned in the context of this disorder. Affiliated tissues include testes, skin and bone, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Disease Ontology:11 A primary bacterial infectious disease that is a sexually transmitted systemic disease, has material basis in Treponema pallidum subsp pallidum, which is transmitted by sexual contact, transmitted by blood product transfusion, transmitted by congenital method from mother to fetus or transmitted by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

CDC:2 You should get tested regularly if you are pregnant, are a man who has sex with men, have HIV infection, and/or have partner(s) who have tested positive for syphilis.

Wikipedia:71 Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies... more...

Related Diseases for Syphilis

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Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 341)
idRelated DiseaseScoreTop Affiliating Genes
1basilar artery occlusion29.4CD40LG, CD79A, EXTL3
2early yaws29.1B2M, CD40LG, CD79A
3congenital syphilis12.4
4tertiary syphilis12.3
5latent syphilis12.3
6secondary syphilis12.3
7primary syphilis12.2
8cardiovascular syphilis12.2
9late congenital syphilis12.2
10early congenital syphilis12.1
11gummatous syphilis12.1
12bejel11.8
13asymptomatic neurosyphilis11.6
14neurosyphilis11.6
15tertiary neurosyphilis11.5
16syphilitic aseptic meningitis11.5
17tabes dorsalis11.0
18smallpox11.0
19variola major10.7
20mikulicz disease10.7
21chronic rhinitis10.7
22variola minor10.7
23idiopathic hypertrophic pachymeningitis10.7
24progressive locomotor ataxia10.7
25syphilitic spinal sclerosis10.7
26alcoholic neuropathy10.4CD40LG, CD79A
27camptodactyly vertebral fusion10.4CD40LG, CD79A
28spinal polio10.4CD40LG, CD79A
29rabies10.4CD40LG, CD79A
30unilateral retinoblastoma10.4CD40LG, CD79A
31mesangial proliferative glomerulonephritis10.3CD40LG, CD79A
32delta chain disease10.3CD40LG, CD79A
33discitis10.3CD40LG, CD79A
34spinal canal and spinal cord meningioma10.3CD40LG, CD79A
35trichostrongyloidiasis10.3CD40LG, CD79A
36colloid adenoma10.3CD40LG, CD79A
37heart septal defect10.3CD40LG, CD79A
38retinal microaneurysm10.3CD40LG, CD79A
39pediatric meningioma10.3CD40LG, CD79A
40tonsil cancer10.3CD40LG, CD79A
41indomethacin antenatal infection10.3CD40LG, CD79A
42diabetic peripheral angiopathy10.3CD40LG, EXTL3
43postcricoid region cancer10.3CD40LG, CD79A
44cysticercosis10.3CD40LG, EXTL3
45beach ear10.3CD40LG, CD79A
46acute kidney tubular necrosis10.3CD40LG, CD79A
47atheroembolism of kidney10.3CD40LG, CD79A
48partial sensory epilepsy10.3CD40LG, CD79A
49myeloid leukemia10.3APOH, CD40LG
50exhibitionism10.3APOH, CD40LG

Comorbidity relations with Syphilis via Phenotypic Disease Network (PDN):


Hypertension, EssentialDeficiency Anemia
Schizophreniform DisorderAcute Cystitis

Graphical network of the top 20 diseases related to Syphilis:



Diseases related to syphilis

Symptoms & Phenotypes for Syphilis

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UMLS symptoms related to Syphilis:


syphilitic chancre, fever, pelvic pain, pruritus, gummatous inflammation

MGI Mouse Phenotypes related to Syphilis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.4APOH, B2M, CAT, CD40LG, CD79A, EXTL3
2MP:00107686.3APOH, B2M, CAT, CD40LG, EXTL3, FAS

Drugs & Therapeutics for Syphilis

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Drugs for Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 87)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Penicillin Gapproved, vet_approvedPhase 4, Phase 33161-33-65904
Synonyms:
(2S,5R,6R)-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(5R,6R)-Benzylpenicillin
(Phenylmethyl)penicillin
(Phenylmethyl)penicillinic acid
113-98-4 (mono-potassium salt)
2,2-dimethyl-6beta-(phenylacetamido)penam-3alpha-carboxylate
2,2-dimethyl-6beta-(phenylacetamido)penam-3alpha-carboxylic acid
4-27-00-05861 (Beilstein Handbook Reference)
46609_FLUKA
46609_RIEDEL
6-(2-Phenylacetamido)penicillanic acid
6-(2-phenylacetamido)penicillanic acid
61-33-6
69-57-8 (mono-hydrochloride salt)
AB00384263
AC-14408
AC1L1LDX
AC1LD0NQ
AC1Q2CBJ
AR-1K9813
Abbocillin
Ayercillin
BPBio1_001206
BRD-K55191674-236-03-7
BRD-K55191674-237-02-7
BRN 0044740
BSPBio_001096
BSPBio_002183
Bencilpenicilina
Bencilpenicilina [Spanish]
Benzopenicillin
Benzyl penicillin
Benzyl-6-aminopenicillinic acid
Benzylpenicillin
Benzylpenicillin (INN)
Benzylpenicillin G
Benzylpenicillin [INN:BAN]
Benzylpenicillin potassium
Benzylpenicillin potassium (JP15)
Benzylpenicillin potassium salt
Benzylpenicilline
Benzylpenicilline [French]
Benzylpenicillinic acid
Benzylpenicillinum
Benzylpenicillinum [Latin]
Benzylpénicilline
Bicillin
Bicillin (*Benzathine Salt, Tetrahydrate*)
Bio-0602
C05551
C16H18N2O4S
CHEBI:18208
CHEBI:51354
CHEBI:7963
CHEMBL1223
CHEMBL29
CID443084
CID5904
CID640429
Cillora
Cilloral
Cilopen
Compocillin G
Cosmopen
Crysticillin 300 A.S.
D01053
D02336
DB01053
DivK1c_000316
Dropcillin
EINECS 200-506-3
Free benzylpenicillin
Free penicillin G
Free penicillin II
Galofak
Gelacillin
HMS1920F12
HMS2091N12
 
HMS500P18
HSDB 3166
I06-1083
IDI1_000316
KBio1_000316
KBio2_001413
KBio2_003981
KBio2_006549
KBio3_001683
KBioGR_000942
KBioSS_001413
LS-149836
LS-195224
Liquacillin
MLS000069426
MLS000766897
MLS001032123
MLS001076462
MLS001173382
Megacillin
MolPort-002-511-679
MolPort-003-666-255
NCGC00021679-03
NCGC00021679-04
NCGC00159348-02
NChemBio.2007.21-comp4
NINDS_000316
NSC 193396
P1772
P7794_SIGMA
P8721_SIAL
PCG
PENICILLIN-G
PENK_SIAL
PENK_SIGMA
PG
PNN
Pencillin G
Penicillin
Penicillin G
Penicillin G potassium
Penicillin G potassium (USP)
Penicillin G potassium salt
Penicillin potassium G, crystalline
Penicillin-G potassium
Pfizerpen
Pfizerpen (TN)
Pharmacillin
Phenylacetamidopenicillanic acid
Phenylacetyl-6-aminopenicillanic acid
Pradupen
Prestwick0_001078
Prestwick1_001078
Prestwick2_001078
Prestwick3_001078
SMR000059004
SMR000538912
SPBio_000475
SPBio_002998
SPECTRUM1500465
ST51052951
Sodium benzylpenicillin
Sodium penicillin
Specilline G
Spectrum2_000518
Spectrum3_000542
Spectrum4_000471
Spectrum5_001108
Spectrum_000933
UNII-Q42T66VG0C
Ursopen
ZINC03871701
bensylpenicillin
benzyl benicillin
benzylpenicilline potassique
nchembio.177-comp1
nchembio.252-comp1
penicillin g
potassium 2,2-dimethyl-6beta-(phenylacetamido)penam-3alpha-carboxylate
2
Procaineapproved, investigational, vet_approvedPhase 4, Phase 34959-46-14914
Synonyms:
.beta.-(Diethylamino)ethyl p-aminobenzoate
.beta.-Diethylaminoethyl 4-aminobenzoate
2-(Diethylamino)ethyl 4-aminobenzoate
2-(Diethylamino)ethyl p-aminobenzoate
2-(Diethylamino)ethyl-4-aminobenzoate
2-Diethylaminoethyl 4-aminobenzoate
2-Diethylaminoethyl p-aminobenzoate
2-Diethylaminoethylester kyseliny p-aminobenzoove
2-Diethylaminoethylester kyseliny p-aminobenzoove [Czech]
4-14-00-01138 (Beilstein Handbook Reference)
4-Aminobenzoesaeure-beta-diethylaminoethylester
4-Aminobenzoic acid 2-(diethylamino) ethyl ester
4-Aminobenzoic acid diethylaminoethyl ester
4-aminobenzoic acid 2-diethylaminoethyl ester
59-46-1
91484-72-9
AB00053531
AC1L1J8C
AC1Q2ZE2
AKOS000115407
Allocaine
Anticort
Anticort (TM)
Anuject
BENZOIC ACID,4-AMINO,2-DIETHYLAMINOETHYL ESTER PROCAIN BASE
BPBio1_000179
BRD-K24616672-003-05-2
BRN 0913480
BSPBio_000161
BSPBio_002231
Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester
Benzoic acid, p-amino-, 2-(diethylamino)ethyl ester
C07375
CAS-51-05-8
CHEBI:8430
CHEMBL569
CID4914
D08422
DB00721
Diethylaminoethyl p-aminobenzoate
DivK1c_000120
Duracaine
EINECS 200-426-9
Factor H3
Gerokit
Gerovital
Gerovital H-3
HSDB 3388
I06-1439
IDI1_000120
InChI=1/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H
Jenacain
Jenacaine
KBio1_000120
KBio2_001318
KBio2_003886
KBio2_006454
KBio3_001731
 
KBioGR_000975
KBioSS_001318
LS-35778
Lopac-P-9879
Lopac0_000966
MolPort-000-889-177
NCGC00015864-01
NCGC00015864-02
NCGC00015864-04
NCGC00162298-01
NINDS_000120
NSC 169497
NSC169497
Nissocaine
Norocaine
Novocain
Novocaine
Prestwick0_000041
Prestwick1_000041
Prestwick2_000041
Prestwick3_000041
Procain
Procaina
Procaina [INN-Spanish]
Procaine (INN)
Procaine HCl
Procaine [INN:BAN]
Procaine, base
Procainum
Procainum [INN-Latin]
SP-01A
SP01
SP01A
SPBio_001331
SPBio_002082
STK177303
STOCK2S-12721
Scurocaine
Solution of novocain
Solution of novocain (TN)
Spectrum2_001296
Spectrum3_000556
Spectrum4_000488
Spectrum5_001186
Spectrum_000838
Spinocaine
Stoff H3
UNII-4Z8Y51M438
Vitamin H3
WLN: ZR DVO2N2&2
beta-(Diethylamino)ethyl 4-aminobenzoate
beta-(Diethylamino)ethyl p-aminobenzoate
beta-Diethylaminoethyl 4-aminobenzoate
p-Aminobenzoic acid 2-diethylaminoethyl ester
p-Aminobenzoyldiethylaminoethanol
p-Aminobenzyoyldiethylaminoethanol
procaine
β-(diethylamino)ethyl 4-aminobenzoate
β-(diethylamino)ethyl p-aminobenzoate
3
Doxycyclineapproved, investigational, vet_approvedPhase 4, Phase 3, Early Phase 1243564-25-054671203
Synonyms:
(2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
10597-92-9
17086-28-1 (mono-hydrate)
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)
24390-14-5
41411-66-9 (6-epimer, mono-hydrochloride)
5-Hydroxy-alpha-6-deoxytetracycline
5-hydroxy-α-6-deoxytetracycline
564-25-0
6-Deoxyoxytetracycline
6-Deoxytetracycline
6-alpha-Deoxy-5-oxytetracycline
6-alpha-deoxy-5-oxytetracycline
69935-17-7 (mono-hydrochloride, di-hydrate)
6alpha-Deoxy-5-oxytetracycline
6alpha-deoxy-5-oxytetracycline
6α-deoxy-5-oxytetracycline
7164-70-7
7264-10-0
94088-85-4 (calcium salt (1:2))
AB08 (*Fosfatex)
AC1NQXW7
AC1NS4CW
AC1NUYS8
AC1O8PYM
Alti-Doxycycline
Anhydrous doxycycline
Apo-Doxy
Atridox
Azudoxat
BCBcMAP01_000024
BIDD:GT0146
BMY-28689
BPBio1_000951
BSPBio_000863
BSPBio_001936
BU-3839T
C06973
CHEBI:50845
CHEMBL1433
CID5281011
CID5353597
CID5463943
CID6713981
CPD001550033
D07876
DB00254
DMSC (*Fosfatex)
DOXCYCLINE ANHYDROUS
DOXY
DOXYCYCLINE CALCIUM
DOXYCYCLINE MONOHYDRATE
Deoxymykoin
DivK1c_000345
Dossiciclina
Dossiciclina [DCIT]
Doxcycline anhydrous
Doxiciclina
Doxiciclina [INN-Spanish]
Doxiciclina [Italian]
Doxitard
Doxivetin
Doxy-Caps
Doxy-Puren
Doxy-Tabs
Doxycen
Doxychel
Doxychel (TN)
Doxycin
Doxycyclin
Doxycycline (200mg/day) or Placebo
 
Doxycycline (INN)
Doxycycline (TN)
Doxycycline (anhydrous)
Doxycycline (internal use)
Doxycycline Hyclate
Doxycycline Monohydrate
Doxycycline anhydrous
Doxycycline hyclate
Doxycycline-Chinoin
Doxycyclinum
Doxycyclinum [INN-Latin]
Doxysol
Doxytec
Doxytetracycline
EINECS 209-271-1
GS-3065 (*monohydrate)
HMS2090E06
HSDB 3071
Hydramycin
IDI1_000345
Investin
Jenacyclin
KBio1_000345
KBio2_001287
KBio2_003855
KBio2_006423
KBio3_001156
KBioGR_001133
KBioSS_001287
LS-187766
LS-93868
Liviatin
Lopac0_000405
MolPort-002-507-423
Monodox
Monodox (*monohydrate)
NCGC00161602-01
NCGC00161602-03
NCGC00161602-04
NCGC00167961-01
NCGC00179395-01
NINDS_000345
NSC633557
Novo-Doxylin
Nu-Doxycycline
Oracea
Prestwick0_000852
Prestwick1_000852
Prestwick2_000852
Prestwick3_000852
Ronaxan
SAM002589932
SMP1_000107
SPBio_000246
SPBio_002784
STOCK1N-34341
Spanor
Spectrum2_000143
Spectrum3_000408
Spectrum4_000527
Spectrum5_000947
Spectrum_000807
Supracyclin
UNII-334895S862
UPCMLD-DP021
UPCMLD-DP021:001
Vibra-tabs
Vibramycin
Vibramycin (*monohydrate)
Vibramycin Novum
Vibramycine
Vibravenos
Vivox (*Hyclate)
alpha-6-Deoxy-5-hydroxytetracycline
alpha-6-Deoxyoxytetracycline
alpha-Doxycycline
doxycycline
4
Tenofovirapproved, investigationalPhase 4759147127-20-6464205
Synonyms:
(R)-9-(2-Phosphonomethoxypropyl)adenine
(R)-9-(2-Phosphonylmethoxypropyl)adenine
(R)-9-(2-phosphonomethoxypropyl)adenine
(R)-PMPA
147127-20-6
206184-49-8
AC-760
AC1LA9BO
Anh. tenofovir
Anhydrous tenofovir
Apropovir
CHEBI:45809
CHEMBL483
CID464205
D,L-Tenofovir
DB00300
GNA & Tenofovir
GS 1275
GS 1278
GS1278
 
HHA & Tenofovir
KS-5021
MolPort-003-850-411
NCGC00167535-01
PMPA
PMPA-(R)
Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- & Galanthus nivalis agglutinin (GNA)
Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- & Hippeastrum hybrid agglutinin( HHA)
Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- (9CI)
Phosphonic acid, [[2-(6-amino-9H-purin-9
S1401_Selleck
TDF
TFV
Tenefovir
Tenofovir
Tenofovir (anh.)
Tenofovir disoproxil
Tenofovir disoproxil fumarate
UNII-99YXE507IL
Viread
Viread, Tenofovir
[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid
5
Emtricitabineapproved, investigationalPhase 4457143491-57-060877
Synonyms:
(-)-(2R,5S)-5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
(-)-(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
(-)-.beta.-L-FTC
(-)-2',3'-Dideoxy-5-fluoro-3'-thiacytidine
(-)-2'-Deoxy-5-fluoro-3'-thiacytidine
(-)-FTC
(-)-beta-2',3'-Dideoxy-5-fluoro-3'-thiacytidine
(-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine
(-)-cis-4-amino-5-Fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one
(-)-cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one
(2R-cis)-4-Amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone
(2R-cis)-4-amino-5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone
.beta.-L-(-)-(2R,5S)-5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
1-(2-(Hydroxymethyl)oxathiolan-5-yl)-5-fluorocytosine
143491-54-7
143491-57-0
145213-48-5
2',3',5-FTC
2',3'-Dideoxy-5-fluoro-3'-thiacytidine
2'-Deoxy-5-fluoro-3'-oxa-4'-thiocytidine
2'-Deoxy-5-fluoro-3'-thiacytidine
2-FTC
3'-Thia-2'.3'-dideoxy-5-fluorocytidine
4-Amino-5-fluoro-1-((2R,5S)-2-hydroxymethyl-[1,3]oxathiolan-5-yl)-1H-pyrimidin-2-one
4-Amino-5-fluoro-1-[(2R,5S)-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
4-amino-5-Fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one
4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one
5-Fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)[1,3]oxathiolan-5-yl]cytosine
524W91
AC1L1U3I
AC1Q4KUB
BW 1592
 
BW 524W91
BW-524W91
BW524W91
C122114
C12599
C8H10FN3O3S
CHEBI:31536
CHEMBL885
CID60877
Coviracil
Coviracil(TM)
D01199
DB00879
DRG-0208
Emtricitabin
Emtricitabina
Emtricitabine
Emtricitabine (JAN/USAN/INN)
Emtricitabinum
Emtriva
Emtriva (TN)
Emtriva(TM)
FT-0080009
HMS2089I05
HSDB 7337
LS-135838
LS-173184
NCGC00164564-01
RCV
Racivir
SBB066061
TL8000958
UNII-G70B4ETF4S
ZINC03629271
beta-L-2',3'-dideoxy-5-fluoro-3'-thiacytidine
dOTFC
emtricitabine
6Anti-Bacterial AgentsPhase 4, Phase 3, Early Phase 111226
7Penicillin G BenzathinePhase 4, Phase 331
8penicillinsPhase 4, Phase 3114
9Antiprotozoal AgentsPhase 4, Phase 3, Early Phase 12051
10Anti-Infective AgentsPhase 4, Phase 3, Phase 2, Phase 1, Early Phase 122062
11Antiparasitic AgentsPhase 4, Phase 3, Early Phase 12199
12AntimalarialsPhase 4, Phase 3, Early Phase 11246
13Penicillin G ProcainePhase 4, Phase 331
14Anti-Retroviral AgentsPhase 43296
15Antiviral AgentsPhase 49967
16Reverse Transcriptase InhibitorsPhase 41913
17Anti-HIV AgentsPhase 43162
18Nucleic Acid Synthesis InhibitorsPhase 4, Phase 34962
19
Heroinapproved, illicitPhase 3115561-27-35462328
Synonyms:
(5α,6α)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol diacetate (ester)
3,6-Diacetylmorphine
7,8-Dihydro-4,5-alpha-epoxy-17-methylmorphinan-3,6-alpha-diol diacetate
Diacetylmorphine
 
Diamorphine
O,O'-Diacetylmorphine
Smack
diacetylmorphine
diamorphine
20
Guaifenesinapproved, vet_approvedPhase 364193-14-13516
Synonyms:
3-(2-Methoxyphenoxy)-1,2-propanediol
3-(O-Methoxyphenoxy)-1,2-propanediol
3-(O-Methoxyphenoxy)-propanediol-1,2
3-O-Methoxyphenoxypropane 1:2-diol
Actifed C
Aeronesin
Amonidren
Amonidrin
Aresol
Benylin-E
Bronchol
Glycerin ether
Glycerin guaiacolate
Glycero-guaiacol ether
Glycerol a-(2-methoxyphenyl) ether
Glycerol a-(O-methoxyphenyl)ether
Glycerol a-guaiacyl ether
Glycerol a-guiacyl ether
Glycerol a-monoguaiacol ether
Glycerol guaiacolate
Glycerol mono(2-methoxyphenyl) ether
Glycerol-a-guajakolether
Glycerol-alpha-guajakolether
Glyceryl guaiacol
Glyceryl guaiacol ether
Glyceryl guaiacolate
Glyceryl guaiacolate ether
Glyceryl guaiacyl ether
Glyceryl guaicolate
Glyceryl guiacolate
 
Glycerylguaiacol
Guaiacol glycerol ether
Guaiacol glyceryl ether
Guaiacolglicerinetere
Guaiacuran
Guaiacurane
Guaiacyl glyceryl ether
Guaiamar
Guaianesin
Guaicol glycerine ether
Guaicol glyceryl ether
Guaifenesin
Guaifenesine
Guaiphenesin
Guaiphenesine
Guaiphesin
Hustosil
Methoxypropanediol
Methphenoxydiol
Metossipropandiolo
O-Methoxyphenyl glyceryl ether
Organidin NR
Pneumomist
Propanosedyl
Reduton
Robitussin
a-Glyceryl guaiacol ether
a-Glyceryl guaiacolate ether
alpha-Glyceryl guaiacol ether
alpha-Glyceryl guaiacolate ether
guaiphenesin
p-Cresyl acetate
21
MethadoneapprovedPhase 333076-99-34095
Synonyms:
(+)-Methadone
(+-)-Methadone
(+/-)-Methadone
(+/-)-Methadone hydrochloride
(+/-)-Tussal
(-)-(R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone
(-)-Methadone
(6R)-Methadone
(R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone
(R)-6-(Dimethylamino)-4,4-diphenyl-3-hetpanone
(S)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone
(±)-methadone
1095-90-5 (hydrochloride)
297-88-1
3-14-00-00278 (Beilstein Handbook Reference)
3-14-00-00279 (Beilstein Handbook Reference)
3-Hetpanone, 6-(dimethylamino)-4,4-diphenyl-, (R)- (9CI)
5653-80-5
6-(Dimethylamino)-4,4-diphenyl-3-heptanone dl-mixture
6-(dimethylamino)-4,4-diphenylheptan-3-one
6-Dimethylamino-4,4-diphenyl-3-heptanone
6-dimethylamino-4,4-di(phenyl)heptan-3-one
6S-Methadone
76-99-3
A 4624
AC-16055
AC1L1HEG
AC1Q2RLW
AN 148
AN-148 (*Hydrochloride*)
Adanon
Adanon hydrochloride
Adolan
Algidon
Algolysin
Algovetin
Althose
Althose hydrochloride
Amidon
Amidone
BRN 3213667
BRN 3213668
BRN 3213669
Biscuits
Butalgin
C07163
CHEBI:6807
CHEMBL651
CID4095
D08195
DB00333
DEA No. 9250
DL-Methadone hydrochloride
Depridol
Dextromethadone
Diaminon
Diaminon hydrochloride
DivK1c_000963
Dl-Methadone
Dollies
Dolly
Dolofin hydrochloride
Dolohepton
Dolophin
Dolophin hydrochloride
Dolophine
Dolophine (*Hydrochloride*)
Dolophine HCL
EINECS 200-996-9
Fenadon
Fenadone
 
Fenadone (*Hydrochloride*)
HSDB 3119
Heptadon
Heptadone
Heptadone (*Hydrochloride*)
Heptanon
Heptanon (*Hydrochloride*)
Heptanon (pharmaceutical)
Hoechst 10820
Hoescht 10820 (*Hydrochloride*)
IDI1_000963
K 174
KBio1_000963
Ketalgin
Ketalgin hydrochloride
L-(+)-Methadone
L-6-(Dimethylamino)-4,4-diphenyl-3-heptanone
L-Polamidon
L000874
LS-74485
LS-74486
LS-74487
Levometadona
Levometadona [INN-Spanish]
Levomethadone [INN]
Levomethadonum
Levomethadonum [INN-Latin]
Levothyl
Mecodin
Mephenon
Metadona
Metadona [INN-Spanish]
Metadona [Spanish]
Metadone
Metadone [DCIT]
Metasedin
Methadon
Methadona
Methadona [Spanish]
Methadone (BAN)
Methadone HCL
Methadone HCL Intensol
Methadone M
Methadone [INN:BAN]
Methadone hydrochloride
Methadonum
Methadonum [INN-Latin]
Methadonum [Latin]
Methadose
Methaquaione
Miadone
Moheptan
MolPort-001-785-650
NINDS_000963
Phenadone
Phenadone (*Hydrochloride*)
Phenadone hydrochloride
Physeptone
Polamidon
Polamidone
Polamivet
Racemic methadone
S-(+)-Methadone
Sedo-Rapide
Tussol
UNII-UC6VBE7V1Z
Westadone
d-6-(Dimethylamino)-4,4-diphenyl-3-heptanone
d-Methadone
dl-Methadone
l-Methadone
l-Polamivet
methadone
22
AzithromycinapprovedPhase 334683905-01-555185, 53477736, 447043
Synonyms:
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one
1-Oxa-6-azacyclopentadecan-15-one, 13-((2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-,(2R-(2R*,3S*
121470-24-4
75199_FLUKA
83905-01-5
9-Deoxo-9a-aza-9a-methyl-9a-homoerythromycin A
AC-16014
AC1L9KEG
Aritromicina
Azasite
Azenil
Azifast
Azigram
Azimakrol
Azithramycine
Azithromycin
Azithromycin & Tumor Necrosis Factor
Azithromycin (AIDS Initiative)
Azithromycin (anhydrous)
Azithromycin Dihydrate
Azithromycin Monohydrate
Azithromycin Sterile
Azithromycin dihydrate
Azithromycin plus Tumor Necrosis Factor
Azithromycine
Azithromycine [French]
Azithromycinum
Azithromycinum [Latin]
Azitrocin
Azitromax
Azitromicina
Azitromicina [Spanish]
Azitromin
Azythromycin
BIDD:GT0792
BRN 5387583
BSPBio_002285
Bio-0676
C38H72N2O12
CCRIS 1961
CHEBI:2955
CHEMBL529
CID447043
CP-62993
CP62,993
CPD000471864
DCH3
DRG-0104
 
DivK1c_000233
HMS1922G12
HMS2094M11
HMS500L15
HSDB 7205
Hemomycin
IDI1_000233
KBio1_000233
KBio2_000787
KBio2_003355
KBio2_005923
KBio3_001505
KBioGR_000731
KBioSS_000787
LS-1834
MLS001055353
MLS001066331
MLS001201763
MLS001304005
MLS001332499
MLS001332500
Misultina
MolPort-002-507-426
N,N-Dimethyl-4-amino-benzaldehyde
NCGC00090753-01
NCGC00090753-02
NINDS_000233
NSC643732
SAM002589961
SMR000471864
SPBio_001544
SPECTRUM1503679
Spectrum2_001582
Spectrum3_000653
Spectrum4_000186
Spectrum5_001867
Spectrum_000307
Sumamed
Tromix
UNII-JTE4MNN1MD
XZ-450
Z-Pak
ZIT
Zentavion
Zithromac
Zithromax
Zithromax IV
Zithromycin
Zitromax
Zitromax Avium 600
Zmas
Zmax
azithromycin
23
AdalimumabapprovedPhase 3494331731-18-116219006
Synonyms:
331731-18-1
Adalimumab
Adalimumab (USAN/INN)
Adalimumab (genetical recombination)
 
Adalimumab (genetical recombination) (JAN)
D02597
Humira
Humira (TN)
Humira Pen
Ig gamma-1 chain C region
24
MethotrexateapprovedPhase 315511959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
25
SulfadoxineapprovedPhase 31322447-57-617134
Synonyms:
2447-57-6
4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
4-Sulfanilamido-5,6-dimethoxypyrimidine
4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide
4-amino-N-[5,6-bis(methyloxy)pyrimidin-4-yl]benzenesulfonamide
46810_RIEDEL
5-25-13-00306 (Beilstein Handbook Reference)
6-(4-Aminobenzenesulfonamido)-4,5-dimethoxypyrimidine
AB00514044
AC-11921
AC1L29DT
AC1Q46GG
Ambap2447-57-6
BPBio1_001286
BRD-K55250441-001-03-1
BRN 0625453
BSPBio_001168
C07630
CAS-2447-57-6
CHEBI:9329
CHEMBL1539
CID17134
D00580
DB01299
EINECS 219-504-9
Fanasil
Fanzil
HMS1571K10
HMS2090P07
HMS2094C19
I09-0529
LS-31247
MLS002154150
MolPort-003-850-341
N'-(5,6-Dimethoxy-4-pyrimidyl)sulfanilamide
N(sup 1)-(5,6-Dimethoxy-4-pyrimidinyl)sulfanilamide
 
N1-(5,6-Dimethoxy-4-pyrimidinyl)sulfanilamide
NCGC00016612-01
NCGC00016612-02
Orthosulfin
Prestwick0_001094
Prestwick1_001094
Prestwick2_001094
Prestwick3_001094
Ro 4-4393
Ro-4-4393
S2511_Selleck
S7821_SIGMA
SMR000857259
SPBio_003054
SULFADOXINE
Sanasil: Sulfadoxine: Sulformetoxin
Solfadossina
Solfadossina [DCIT]
Sulfadoxin
Sulfadoxina
Sulfadoxina [INN-Spanish]
Sulfadoxine
Sulfadoxine (JAN/USP/INN)
Sulfadoxine [USAN:INN:BAN:JAN]
Sulfadoxinum
Sulfadoxinum [INN-Latin]
Sulformethoxine
Sulformetoxine
Sulforthomidine
Sulphadoxine
Sulphormethoxine
Sulphormetoxin
Sulphorthodimethoxine
UNII-88463U4SM5
WR 4073
WR 4873
ZINC00002094
26
Pyrimethamineapproved, vet_approvedPhase 315758-14-04993
Synonyms:
2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine
2,4-Diamino-5-(P-chlorophenyl)-6-ethylpyrimidine
2,4-Diamino-5-(p-chlorophenyl)-6-ethylpyrimidine
2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine
46706_FLUKA
46706_RIEDEL
4753 R.P.
4753 r.p
5-(4'-Chlorophenyl)-2,4-diamino-6-ethylpyrimidine
5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE
5-(4-CHLOROPHENYL)-6-ETHYL-2,4-PYRIMIDINEDIAMINE
5-(4-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine
5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidi nediamine
5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
5-(4-chlorophenyl)-2,4-diamino-6-ethylpyrimidine
5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine
5-(p-chlorophenyl)-6-ethyl-2,4-diaminopyrimidine
5-[4-Chlorophenyl]-6-ethyl-2,4-pyrimidinediamine
58-14-0
AB00052084
AC-7879
AC1L1JDI
AI3-25005
AZT + Pyrimethamine combination
Aventis Brand of Pyrimethamine
BIDD:GT0149
BIDD:PXR0173
BPBio1_000147
BRD-K88429204-001-05-4
BRN 0219864
BSPBio_000133
BSPBio_003282
BW 50-63
BW 5063
C07391
C12H13ClN4
CAS-58-14-0
CCRIS 546
CD
CHEBI:8673
CHEMBL36
CID4993
CP6
CPD000058714
CRL-8131 & Pyrimethamine
CRL-8142 & Pyrimethamine
Chloridin
Chloridine
Chloridyn
D00488
D011739
DB00205
Darachlor
Daraclor
Darapram
Daraprim
Daraprim (TN)
Daraprime
Daraprin
Diaminopyritamin
Disulone
DivK1c_000652
EINECS 200-364-2
EXR-101
Erbaprelina
Ethylpyrimidine
Fansidar
Fansidar (Pyrimethamine/Sulfadoxine)
Glaxo Wellcome Brand of Pyrimethamine
GlaxoSmithKline Brand of Pyrimethamine
HMS1568G15
HMS1920N12
HMS2092E13
HMS502A14
IDI1_000652
KBio1_000652
KBio2_001386
KBio2_003954
 
KBio2_006522
KBio3_002502
KBioGR_001007
KBioSS_001386
Khloridin
L000713
LS-238
Lactoferrin B & Pyrimethamine
Lactoferrin H & Pyrimethamine
MCB-3837
MLS000028606
MLS001148621
MLS002454446
MLS002701881
Malacid
Malocid
Malocide
Maloprim
MolPort-001-783-655
NCGC00016256-01
NCGC00016256-02
NCGC00023188-03
NCGC00023188-04
NCGC00023188-05
NCGC00023188-06
NCGC00023188-07
NCI-C01683
NCI60_002604
NCIOpen2_008313
NINDS_000652
NSC 3061
NSC-3061
NSC3061
Oxaquin
Pirimecidan
Pirimetamin
Pirimetamina
Pirimetamina [INN-Spanish]
Pirimetamina [Spanish]
Prestwick0_000037
Prestwick1_000037
Prestwick2_000037
Prestwick3_000037
Prestwick_504
Primethamine
Pyremethamine
Pyrimethamin
Pyrimethamine (JAN/USP/INN)
Pyrimethamine (Pyr)
Pyrimethamine Hcl
Pyrimethamine [USAN:INN:BAN:JAN]
Pyrimethaminum
Pyrimethaminum [INN-Latin]
RP 4753
S2006_Selleck
SAM002554921
SMR000058714
SPBio_000672
SPBio_002054
SPECTRUM1500520
Spectrum2_000886
Spectrum3_001701
Spectrum4_000494
Spectrum5_001447
Spectrum_000906
TCMDC-123831
TCMDC-125860
Tindurin
Tindurine
Tinduring
UNII-Z3614QOX8W
WLN: T6N CNJ BZ DZ ER DG& F2
WR 2978
Wellcome Brand of Pyrimethamine
ZINC00057464
m alocid
nchembio.215-comp13
nchembio.87-comp22
pyrimethamine
27
chloroquineapproved, vet_approvedPhase 314954-05-72719
Synonyms:
( -)-Chloroquine
(+)-Chloroquine
(-)-Chloroquine
(R)-(-)-Chloroquine
3377 RP opalate
3545-67-3
50-63-5
54-05-7
56598-66-4
58175-86-3
58175-87-4
7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline
7-Chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline
AB00053436
AC1L1EB8
AC1Q2ZA7
AC1Q2ZA8
Amokin
Aralen
Aralen HCl
Arechin
Arechine
Arequin
Arolen
Arthrochin
Artrichin
Avlochlor
Avloclor
BPBio1_000655
BRD-A91699651-065-01-1
BRN 0482809
BSPBio_000595
BSPBio_002001
Bemaco
Bemaphate
Bemasulph
Benaquin
Bipiquin
C07625
C18H26ClN3
CCRIS 3439
CHEBI:3638
CHEMBL76
CID2719
CQ
CU-01000012392-2
Capquin
Chemochin
Chingamin
Chloraquine
Chlorochin
Chlorochine
Chlorochinum
Chloroin
Chloroquin
Chloroquina
Chloroquine
Chloroquine (USP/INN)
Chloroquine (VAN)
Chloroquine Bis-Phosphoric Acid
Chloroquine Phosphate
Chloroquine [USAN:INN:BAN]
Chloroquine phosphate
Chloroquinium
Chloroquinum
Chloroquinum [INN-Latin]
Chlorquin
Cidanchin
Clorochina
Clorochina [DCIT]
Cloroquina
Cloroquina [INN-Spanish]
Cocartrit
D02366
DB00608
Dawaquin
Delagil
Dichinalex
DivK1c_000404
EINECS 200-191-2
Elestol
Gontochin
Gontochin phosphate
HMS2090O03
HSDB 3029
Heliopar
Hydroxychloroquine Sulfate
IDI1_000404
Imagon
 
Ipsen 225
Iroquine
KBio1_000404
KBio2_000592
KBio2_003160
KBio2_005728
KBio3_001221
KBioGR_000778
KBioSS_000592
Khingamin
Klorokin
LS-141726
Lapaquin
Lopac0_000296
Malaquin
Malaquin (*Diphosphate*)
Malaren
Malarex
Mesylith
Miniquine
MolMap_000009
MolPort-001-783-623
N(4)-(7-chloro-4-Quinolinyl)-N(1),N(1)-diethyl-1,4-pentanediamine
N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine
N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine
NCGC00015256-04
NCGC00162120-01
NCI60_000894
NINDS_000404
NSC 187208
NSC14050
NSC187208
Neochin
Nivachine
Nivaquine
Nivaquine B
Pfizerquine
Plaquenil
Prestwick0_000548
Prestwick1_000548
Prestwick2_000548
Prestwick3_000548
Quinachlor
Quinagamin
Quinagamine
Quinercyl
Quingamine
Quinilon
Quinoscan
RP 3377
RP-3377
Resochen
Resochin
Resoquina
Resoquine
Reumachlor
Reumaquin
Rivoquine
Ro 01-6014/N2
Ronaquine
Roquine
SMP2_000034
SN 6718
SN-7618
SPBio_000174
SPBio_002516
ST 21
ST 21 (pharmaceutical)
Sanoquin
Silbesan
Siragan
Solprina
Sopaquin
Spectrum2_000127
Spectrum3_000341
Spectrum4_000279
Spectrum5_000707
Spectrum_000132
Tanakan
Tanakene
Tresochin
Trochin
UNII-886U3H6UFF
W 7618
WIN 244
WLN: T66 BNJ EMY1&3N2&2 IG
chloroquine
nchembio.215-comp4
nchembio.368-comp8
nchembio.87-comp17
{4-[(7-chloroquinolin-4-yl)amino]pentyl}diethylamine
28
leucovorinapproved, NutraceuticalPhase 3323558-05-954575, 6560146, 143
Synonyms:
(5-formyl-5,6,7,8-tetrahydropteroyl)glutamate
(6R,S)-5-Formyltetrahydrofolate
10-Formyl-7,8-dihydrofolate
10-Formyl-7,8-dihydrofolic acid
5-Formyl-5,6,7,8-tetrahydrofolate
5-Formyl-5,6,7,8-tetrahydrofolic acid
5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
5-Formyltetrahydrofolate
5-Formyltetrahydrofolic acid
5-Formyltetrahydropteroylglutamate
5-Formyltetrahydropteroylglutamic acid
5-formyltetrahydrofolic acid
Acide folinique
Calcium citrovorum factor
Calcium folinate
Citrovorum factor
Folinate
Folinic acid
Folinic acid calcium salt
 
Folinic acid calcium salt USP27
Folinic acid-SF
L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid
L-Leucovorin
L-N-[p-[[(2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-Glutamic acid
L-leucovorin
Leucal
Leucovorin calcium
Leucovorin folinic acid
Leucovorinum
Leukovorin
Levoleucovorin
N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
N5-Formyl-5,6,7,8-tetrahydrofolate
N5-Formyl-5,6,7,8-tetrahydrofolic acid
N5-Formyl-THF
N5-Formyltetrahydrofolate
N5-Formyltetrahydrofolic acid
Welcovorin
Wellcovorin
folinate
29
Folic Acidapproved, nutraceutical, vet_approvedPhase 3439259-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
30VaccinesPhase 3, Phase 26611
31Antitussive AgentsPhase 3542
32Respiratory System AgentsPhase 34997
33Central Nervous System DepressantsPhase 313403
34Analgesics, OpioidPhase 33238
35AnalgesicsPhase 311733
36Peripheral Nervous System AgentsPhase 3, Phase 1, Phase 223689
37NarcoticsPhase 33646
38Chlorpheniramine, phenylpropanolamine drug combinationPhase 3641
39Analgesics, Non-NarcoticPhase 36501
40Anti-Inflammatory Agents, Non-SteroidalPhase 34443
41Antirheumatic AgentsPhase 310956
42Anti-Inflammatory AgentsPhase 310729
43Vitamin B ComplexPhase 34337
44AntimetabolitesPhase 312054
45Immunosuppressive AgentsPhase 313086
46Heptavalent Pneumococcal Conjugate VaccinePhase 3465
47Antimetabolites, AntineoplasticPhase 37361
48mometasone furoatePhase 317883919-23-7
49Folic Acid AntagonistsPhase 32257
50Dermatologic AgentsPhase 35806

Interventional clinical trials:

(show top 50)    (show all 114)
idNameStatusNCT IDPhase
1Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 StudyCompletedNCT02611765Phase 4
2Serological Response to Retreatment of Serofast Early Syphilis Cases With Benzathine PenicillinRecruitingNCT02884115Phase 4
3One Dose Versus Three Weekly Doses of Benzathine Penicillin G for Patients With Early SyphilisRecruitingNCT02857959Phase 4
4The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical FindingsRecruitingNCT02871505Phase 4
5Expanded PrEP Implementation in Communities in NSWRecruitingNCT02870790Phase 4
6Tenofovir/Emtricitabine With Doxycycline for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative MSMNot yet recruitingNCT02844634Phase 4
7PrEP Implementation for Mothers in Antenatal CareNot yet recruitingNCT03070600Phase 4
8Introduction Study of Dual HIV & Syphilis Rapid Diagnostic Tests in Antenatal Clinics in ColombiaUnknown statusNCT02454816Phase 2, Phase 3
9(Men Who Have Sex With Men) MSM Community Intervention TrialUnknown statusNCT01068015Phase 3
10Injecting Drug Use Community Intervention TrialUnknown statusNCT01108614Phase 3
11Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the CommunityUnknown statusNCT00124878Phase 3
12Azithromycin/Bicillin SyphilisCompletedNCT00031499Phase 3
13Male Circumcision for HIV Prevention in Rakai, UgandaCompletedNCT00425984Phase 3
14Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV TransmissionCompletedNCT00213083Phase 3
15Single-dose Azithromycin for the Treatment of YawsCompletedNCT01382004Phase 3
16Effectiveness of a Community-level HIV/STD Prevention Intervention in Promoting Safer Sexual Behaviors in High-risk PopulationsCompletedNCT00710060Phase 3
17MEMA Kwa Vijana Trial: Impact of an Adolescent Sexual and Reproductive Health Intervention in Mwanza, TanzaniaCompletedNCT00248469Phase 3
18Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRCCompletedNCT01589289Phase 3
19Protecting From Pneumococcus in Early Life (The PROPEL Trial)RecruitingNCT02628886Phase 3
20Evaluation of the Effectiveness and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo, in Subjects With Rheumatoid Arthritis (RA) Who Are Taking an Existing Medication Called a Tumour Necrosis Factor Alpha Inhibitor But Have Active DiRecruitingNCT02760433Phase 3
21Evaluation of the Effectiveness and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo and Adalimumab, in Subjects With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate But Have Active DiseaseRecruitingNCT02760407Phase 3
22Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With ChemotherapyRecruitingNCT01901094Phase 3
23Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In AfricaTerminatedNCT01103063Phase 3
24Effectiveness of the Diaphragm for HIV PreventionWithdrawnNCT00121459Phase 3
25Safety, Acceptability and Preliminary Effectiveness of Carraguard™ (PC-515) in Preventing HIV/STI TransmissionCompletedNCT00213018Phase 2
26Safety, Acceptability and Preliminary Effectiveness of PC-515 for Vaginal Use as a Possible MicrobicideCompletedNCT00213031Phase 2
27Behavioral Intervention to Reduce Sexual and Injection Risks Among Female Sex Workers Who Also Inject Drugs in MexicoCompletedNCT00840658Phase 2
28A Web-based Intervention Study to Reduce High-risk Sexual Behavior by Persons Living With HIV AIDS (PLWH)CompletedNCT01198418Phase 1, Phase 2
29Lay Health Advisors for Sexually Transmitted Disease PreventionCompletedNCT00207506Phase 1, Phase 2
30Safety and Efficacy Study of Human Autologous Hair Follicle Cells to Treat Androgenetic AlopeciaCompletedNCT01286649Phase 1, Phase 2
31Development of a Methamphetamine Early InterventionCompletedNCT01174654Phase 1, Phase 2
32A Tolerability and Efficacy Study of TU-100 For The Treatment of Postoperative IleusCompletedNCT00266461Phase 2
33BufferGel and PRO 2000/5: Vaginal Gels to Prevent HIV Infection in WomenCompletedNCT00074425Phase 2
34Safer Sex Program for Young African-American MenRecruitingNCT01439503Phase 2
35Development of Immune Globulin Treatment for Avian FluTerminatedNCT00383071Phase 2
36Infections and Autoimmunity: Autobodies Screening in Multiple SclerosisUnknown statusNCT00230204Phase 1
37Computer-Assisted Tailored Cue-card Health [CATCH] StudyCompletedNCT01170741Phase 1
38Safety and Acceptability of Carraguard™ Among HIV-Negative Couples in ThailandCompletedNCT00213057Phase 1
39Fecal Microbiota Transplantation in Pediatric PatientsActive, not recruitingNCT02108821Phase 1
40Syphilis Treatment of Partners TrialUnknown statusNCT02262390
41A Methadone Maintenance Treatment Outcome Study in Three Provinces in ChinaUnknown statusNCT01315054
42Human Papillomavirus Infection and Knowledge and Attitudes About HPV Vaccines Among Men Who Have Sex With Men (MSM)Unknown statusNCT01300689
43Repeat Sexually Transmitted Infection (STI) Patients: Tailored Socio-Contextual Intervention to Reduce HIV RiskUnknown statusNCT01510262
44The Impact of Short-term Financial Incentives on Sexual Behavior and HIV Incidence in LesothoUnknown statusNCT01589965Early Phase 1
45Illness Crisis Adapting in Early or Middle Phase of Patient With Chronic Disease: Study of Meta-cognition ModelUnknown statusNCT01964612
46Evaluation of Therapeutic Management in ESBL-infected Patients or Carriers by Providing and Sharing a Free Tool - the "ESBL toolKIT"and Interventional Study of a Prospective Cohort of HIV+ Patients Searching for Possible Sexual Transmission Factors in ESBUnknown statusNCT02011009
47Preparing for Adolescent HIV Vaccine Trials in South Africa:Unknown statusNCT00944879
48The Contraceptive Choice ProjectUnknown statusNCT01986439
49Web-based Psychological Intervention to Coronary Artery Heart Disease PatientsUnknown statusNCT01998555
50MBCGT and Psycho-physiological Stress Regulation Group for Depression and Psycho-physiological Stress PatientUnknown statusNCT01894932

Search NIH Clinical Center for Syphilis

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: chancre

Genetic Tests for Syphilis

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Anatomical Context for Syphilis

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MalaCards organs/tissues related to Syphilis:

36
Testes, Skin, Bone, Heart, Lymph node, Liver, Tonsil

Publications for Syphilis

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Articles related to Syphilis:

(show top 50)    (show all 2267)
idTitleAuthorsYear
1
Kissing chancre of primary syphilis. (28070492)
2017
2
Factors associated with syphilis incidence in the HIV-infected in the era of highly active antiretrovirals. (28079818)
2017
3
Cytokine Profiles in Aqueous Humor and Plasma of HIV-infected Individuals with Ocular Syphilis or Cytomegalovirus Retinitis. (28081374)
2017
4
Serum microRNA profiles in patients with syphilis. (28079920)
2017
5
Tracing partners of patients with syphilis infection remains challenging: experience of Geneva Hospital. (28081685)
2017
6
Nodular tertiary syphilis in an immunocompetent patient. (27579755)
2016
7
Auckland: city of syphilis? (27977652)
2016
8
Warty mucosal lesions: Oral condyloma lata of secondary syphilis. (27679405)
2016
9
Syphilis among middle-aged female sex workers in China: a three-site cross-sectional study. (27165644)
2016
10
First report of tertiary syphilis presenting as lipoatrophic panniculitis in an immunocompetent patient. (27558164)
2016
11
A case of acute myocardial infarction due to cardiovascular syphilis with aortic regurgitation and bilateral coronary ostial stenosis. (27873284)
2016
12
Syphilis, a curable cause of acute polyarthritis. (27216318)
2016
13
Periostitis in secondary syphilis with prozone phenomenon. (27498354)
2016
14
Papulonodular secondary syphilis: a rare clinic presentation confirmed by serologic and histologic exams. (27192520)
2016
15
Recurrent Jarisch-Herxheimer reaction in late latent syphilis. (26834029)
2016
16
Differential declines in syphilis-related mortality in the United States, 2000-2014. (28007309)
2016
17
Syphilis screening in pregnancy in the United Kingdom, 2010-2011: a national surveillance study. (27219027)
2016
18
Unusual primary syphilis: Presentation of a likely case with a review of the stages of acquired syphilis, its differential diagnoses, management, and current recommendations. (26756536)
2016
19
Pulmonary Consolidations due to Secondary Syphilis with Positive Bronchial Washing Immunohistochemistry. (26840562)
2016
20
Population Dependency of Measles, Syphilis and Amebiasis in Japan and Community Evolution. (27795472)
2016
21
Identifying and interpreting spatiotemporal variation in diagnoses of infectious syphilis among men, England: 2009 to 2013. (27147614)
2016
22
Secondary syphilis presenting with aortitis and coronary ostial occlusion. (26670911)
2016
23
Infectious and congenital syphilis notifications associated with an ongoing outbreak in northern Australia. (27080030)
2016
24
High frequency of neurosyphilis in HIV-positive patients diagnosed with early syphilis. (27089861)
2016
25
Secondary syphilis in the oral cavity and the role of the dental surgeon in STD prevention, diagnosis and treatment: a case series study. (27208390)
2016
26
Bilateral Chorioretinitis as Syphilis Presentation: Multimodal Characterization and Therapy Response. (27790481)
2016
27
Infant Deaths Due To Herpes Simplex Virus, Congenital Syphilis, and HIV in New York City. (26933212)
2016
28
Out-of-Hospital screening for HIV, HBV, HCV and Syphilis in a vulnerable population, a public health challenge. (27626811)
2016
29
Immune reconstitution inflammatory syndrome associated with secondary syphilis. (27566775)
2016
30
Performance Evaluation of a Novel Chemiluminescence Assay Detecting Treponema Pallidum Antibody as a Syphilis Screening Method. (27215069)
2016
31
Seroprevalence of hepatitis B and syphilis co-infection in human immunodeficiency virus-positive antiretroviral therapy attendees and human immunodeficiency virus-negative sexually transmitted infection attendees. (27190426)
2016
32
Global challenges in human immunodeficiency virus and syphilis coinfection among men who have sex with men. (27626361)
2016
33
Evaluation of the management of pregnancies and infants at risk for congenital syphilis: La RAcunion, 2008 to 2014. (27711044)
2016
34
Cuba Validated as the First Country to Eliminate Mother-to-Child Transmission of Human Immunodeficiency Virus and Congenital Syphilis: Lessons Learned from the Implementation of the Global Validation Methodology. (27835624)
2016
35
Clinical Evaluation of 2 Point-of-Care Lateral Flow Tests for the Diagnosis of Syphilis. (27631356)
2016
36
Changing trend of HIV, Syphilis and Hepatitis C among Men Who Have Sex with Men in China. (27535092)
2016
37
Syphilis in an Infant Acquired by Mouth-to-Mouth Transfer of Prechewed Food. (27573471)
2016
38
Application of Goldmag immune probe in timely detection of syphilis based on GIS platform. (27152908)
2016
39
Primary syphilis: An uncommon manifestation in the oral cavity. (27502894)
2016
40
Risk profiles of neurosyphilis in HIV-negative patients with primary, secondary and latent syphilis: implications for clinical intervention. (26660338)
2016
41
Syphilis in Pregnancy and Congenital Syphilis: Why Can We not yet Face This Problem? (27756083)
2016
42
The sins of the fathers will be visited upon the children": Congenital syphilis and leg braces pictorial depiction in eighteenth century Britain. (27421914)
2016
43
Human Immunodeficiency Virus-Infected Man With Acute Visual Impairment and Panuveitis Due to Syphilis Despite Initially Negative Rapid Plasma Reagin. (27893602)
2016
44
Characterization and six-month follow-up on a cohort of newborns with congenital syphilis. (27622443)
2016
45
Global burden of maternal and congenital syphilis in 2008 and 2012: a health systems modelling study. (27443780)
2016
46
Seroprevalence and diagnosis of HIV, HBV, HCV and syphilis infections among blood donors. (28009328)
2016
47
The Global Epidemiology of Syphilis in the Past Century - A Systematic Review Based on Antenatal Syphilis Prevalence. (27167068)
2016
48
The Significance of Isolated Reactive Treponemal Enzyme Immunoassay in the Diagnosis of Early Syphilis. (27196257)
2016
49
Analytical and clinical comparison of Elecsys syphilis (RocheAr) - Architect syphilis TP and reformulated Architect syphilis TP (AbbottAr) assay. (28012638)
2016
50
Skin rash: a manifestation of early congenital syphilis. (27268292)
2016

Variations for Syphilis

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Copy number variations for Syphilis from CNVD:

6
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1111152173509791835138441Copy numberERBB2Syphilis

Expression for genes affiliated with Syphilis

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Search GEO for disease gene expression data for Syphilis.

Pathways for genes affiliated with Syphilis

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GO Terms for genes affiliated with Syphilis

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Cellular components related to Syphilis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ER to Golgi transport vesicle membraneGO:00125079.8B2M, HLA-C, HLA-DRB1
2MHC class I protein complexGO:00426129.3B2M, HLA-C
3focal adhesionGO:00059259.2B2M, CAT, MYH9, PPIB
4external side of plasma membraneGO:00098979.1B2M, CD209, CD40LG, CD79A, FAS, HLA-DRB1
5cell surfaceGO:00099868.5APOH, B2M, CD209, CD40LG, FAS, HLA-C
6extracellular exosomeGO:00700626.9APOH, B2M, CAT, CD209, FAS, FN1
7membraneGO:00160205.5B2M, CAT, CD209, CD40LG, CD79A, EXTL3

Biological processes related to Syphilis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1leukocyte cell-cell adhesionGO:000715910.5CD209, CD40LG
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:000248010.1B2M, HLA-C
3antigen processing and presentationGO:00198829.9CD209, HLA-C, HLA-DRB1
4interferon-gamma-mediated signaling pathwayGO:00603339.6B2M, HLA-C, HLA-DRB1
5immune system processGO:00023769.0B2M, CD209, CD79A, HLA-C, HLA-DRB1
6immune responseGO:00069558.9B2M, CD40LG, FAS, HLA-C, HLA-DRB1
7viral processGO:00160328.6CD209, HLA-C, HLA-DRB1, TPR

Molecular functions related to Syphilis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.4CD209, HLA-C, HLA-DRB1
2protein anchorGO:00434959.1MYH9, TPR

Sources for Syphilis

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet