MCID: SYP003
MIFTS: 57

Syphilis malady

Infectious diseases, Neuronal diseases categories
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Summaries for Syphilis

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Sources:
8Disease Ontology, 34MedlinePlus, 4CDC, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Syphilis is a sexually transmitted disease caused by bacteria. it infects the genital area, lips, mouth, or anus of both men and women. you usually get syphilis from sexual contact with someone who has it. it can also pass from mother to baby during pregnancy. the early stage of syphilis usually causes a single, small, painless sore. sometimes it causes swelling in nearby lymph nodes. if you do not treat it, syphilis usually causes a non-itchy skin rash, often on your hands and feet. many people do not notice symptoms for years. symptoms can go away and come back. the sores caused by syphilis make it easier to get or give someone hiv during sex. if you are pregnant, syphilis can cause birth defects, or you could lose your baby. in rare cases, syphilis causes serious health problems and even death. syphilis is easy to cure with antibiotics if you catch it early. correct usage of latex condoms greatly reduces, but does not completely eliminate, the risk of catching or spreading syphilis. nih: national institute of allergy and infectious diseases

MalaCards: Syphilis, also known as syphilis, unspecified, is related to hepatitis b and glomerulonephritis. An important gene associated with Syphilis is CD40LG (CD40 ligand), and among its related pathways are Primary immunodeficiency and B Cell Receptor Signaling Pathway. The drug erythromycin pwdr and the compounds sulfolipid i and sandoglobulin have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and lymph node, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Disease Ontology:8 A primary bacterial infectious disease that is a sexually transmitted systemic disease, has material basis in treponema pallidum subsp pallidum, which is transmitted by sexual contact, transmitted by blood product transfusion, transmitted by congenital method from mother to fetus or transmitted by contact with infectious lesions. if left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

CDC:4 Syphilis is an STD that can have very serious complications when left untreated.

Wikipedia:65 Syphilis is a sexually transmitted infection caused by the spirochete bacterium Treponema pallidum... more...

Aliases & Classifications for Syphilis

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

syphilis 8 10 45 34 62
syphilis, unspecified 8
syphilitic chancre 8
syphilis nos 8


External Ids:

Disease Ontology8 DOID:4166
MeSH35 D002601
ICD1025 A53.9

Related Diseases for Syphilis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Syphilis family:

Primary Syphilis Late Congenital Syphilis
Early Congenital Syphilis Congenital Syphilis

Diseases related to Syphilis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 267)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis b30.7CCR5, ABCB7
2glomerulonephritis30.5CCR5, CD79A, CD40LG
3hepatitis c30.4CD40LG, CCR5, ABCB7
4toxoplasmosis30.4CD79A, CD40LG
5antiphospholipid syndrome30.3APOH, CD79A, CD40LG
6rubella30.3CD40LG, CD79A
7lupus erythematosus30.3CD40LG, CD79A, APOH
8vasculitis30.2APOH, CD79A, CD40LG
9membranous glomerulonephritis30.2CCR5, CD79A
10systemic lupus erythematosus30.1APOH, CCR5, CD79A, CD40LG
11chickenpox29.9CD79A
12q fever29.9CD79A
13thrombocytopenia29.9ABCB7, APOH, CD79A, CD40LG
14viral hepatitis29.8ABCB7
15infectious mononucleosis29.8CD79A, CD40LG
16behcet's disease29.8APOH, CCR5
17rheumatic disease29.8CD40LG, APOH
18rheumatoid arthritis29.7APOH, CCR5, CD79A, CD40LG
19atherosclerosis29.6APOH, CCR5, CD209, CD40LG
20congenital syphilis11.2
21secondary syphilis11.2
22primary syphilis10.9
23cardiovascular syphilis10.8
24latent syphilis10.8
25tertiary syphilis10.8
26hepatitis10.7
27yaws10.7
28early congenital syphilis10.7
29neurosyphilis10.6
30gonorrhea10.6
31late congenital syphilis10.5
32bejel10.5
33nephrotic syndrome10.4
34gummatous syphilis10.4
35interstitial keratitis10.4
36keratitis10.4
37lymphogranuloma venereum10.3
38periostitis10.3
39uveitis10.3
40tonsillitis10.3
41leprosy10.3
42chancroid10.2
43choroiditis10.2
44alopecia10.2
45chorioretinitis10.2
46lichen planus10.2
47asymptomatic neurosyphilis10.2
48arthritis10.2
49meningitis10.2
50tuberculosis10.2

Graphical network of the top 20 diseases related to Syphilis:



Diseases related to syphilis

Symptoms for Syphilis

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Drugs & Therapeutics for Syphilis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Syphilis

Search NIH Clinical Center for Syphilis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Syphilis

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Anatomical Context for Syphilis

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Sources:
33MalaCards
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MalaCards organs/tissues related to Syphilis:

33
Testes, Skin, Lymph node, Bone, Liver, Tonsil, Tongue, Spinal cord, Prostate, Eye, T cells, Heart, Temporal lobe, Trachea, Placenta, Uterus, Breast, Adrenal gland, Lung, Kidney, Retina, Brain, Spleen, Pituitary

Animal Models for Syphilis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Syphilis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.6CD40LG, CD209, CCR5, APOH, ABCB7
2MP:00053766.8CD40LG, ABCB7, APOH, CCR5, CD79A, CD209

Publications for Syphilis

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Sources:
52PubMed
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Articles related to Syphilis:

(show top 50)    (show all 1983)
idTitleAuthorsYear
1
The prevalence of syphilis at childbirth in Ireland: a six-year review. (24354591)
2014
2
Associated factors for HIV and syphilis infection among men who have sex with men only and men who have sex with both men and women in cities of China. (23970661)
2013
3
Predictors of serological failure after treatment in HIV-infected patients with early syphilis in the emerging Era of universal antiretroviral therapy use. (24369955)
2013
4
Usefulness of IgM-specific enzyme immunoassays for serodiagnosis of syphilis: comparative evaluation of three different assays. (23542782)
2013
5
HBsAg, anti-HCV, anti-HIV 1/2 and syphilis seroprevalence in healthy volunteer blood donors in southeastern Anatolia. (24042102)
2013
6
Human leukocyte antigen-C and killer cell immunoglobulin-like receptor gene polymorphisms among patients with syphilis in a Chinese Han population. (22958291)
2012
7
Footprint of positive selection in Treponema pallidum subsp. pallidum genome sequences suggests adaptive microevolution of the syphilis pathogen. (22720110)
2012
8
Letter to the editor: Syphilis seroreactivity: determining the importance during routine screening. (22973148)
2012
9
Syphilis: still a major cause of infant mortality. (22459083)
2012
10
Syphilis infection among homosexual men reporting contact with syphilis: a case control study. (22907046)
2012
11
Current practices of partner notification among MSM with HIV, gonorrhoea and syphilis in the Netherlands: an urgent need for improvement. (22583517)
2012
12
Unilateral solitary choroidal granuloma as presenting sign of secondary syphilis. (21562892)
2011
13
Is it useful to perform a chest X-ray in asymptomatic patients with late latent syphilis? (21427433)
2011
14
Case of secondary syphilis presenting with unusual complications: syphilitic proctitis, gastritis, and hepatitis. (21998411)
2011
15
Circumscribed lenticular anetoderma in an HIV-infected man with a history of syphilis and lichen planus. (22031628)
2011
16
Cholestatic hepatitis and thrombocytosis in a secondary syphilis patient. (21060758)
2010
17
Primary syphilis cases in Guangdong Province 1995-2008: opportunities for linking syphilis control and regional development. (21192782)
2010
18
Possible autoimmune reactions following smallpox vaccination: the biologic false positive test for syphilis. (19022322)
2009
19
Cardiovascular syphilis. (19068539)
2008
20
The outcome of treatment of early latent syphilis and syphilis with undetermined duration in HIV-infected and HIV-uninfected patients. (18073011)
2007
21
Nodular secondary syphilis mimicking cutaneous lymphoreticular process. (18032877)
2007
22
Subclinical acquired syphilis masquerading as membranous glomerulonephritis. (17243528)
2006
23
Congenital syphilis--United States, 2002. (15306757)
2004
24
Detection of Treponema pallidum in skin lesions of secondary syphilis and characterization of the inflammatory infiltrate. (15056995)
2004
25
Incidence determinants of gonorrhea, chlamydial genital infection, syphilis and chancroid in attendees at a sexually transmitted disease clinic in Athens, Greece. (14636203)
2003
26
Sexually transmitted diseases in women. Gonorrhea and syphilis. (10689416)
2000
27
Congenital syphilis: subtle presentation of fulminant disease. (9039217)
1997
28
Congenital syphilis: still a reality in 1996. (8890847)
1996
29
Neonatal hypoglycemia caused by hypopituitarism in infants with congenital syphilis. (8229534)
1993
30
Distinguishing beta 2-glycoprotein I dependent (systemic lupus erythematosus type) and independent (syphilis type) anticardiolipin antibody with Tween 20. (7918046)
1993
31
Granulomatous hepatitis in secondary syphilis. (2189840)
1990
32
Sexually transmitted diseases and native Americans: trends in reported gonorrhea and syphilis morbidity, 1984-88. (2511589)
1989
33
Leads from the MMWR. Syphilis and congenital syphilis--United States, 1985-1988. (3411729)
1988
34
Repair of a palatal defect associated with late congenital syphilis using a tongue flap. (3276855)
1988
35
Transverse myelitis due to meningovascular syphilis. (6696656)
1984
36
Physicians' recognition of the signs and symptoms of secondary syphilis. (7241768)
1981
37
Secondary syphilis with iris papules. (7191640)
1980
38
Bell's palsy and secondary syphilis: CSF spirochetes detected by immunofluorescence. (365078)
1978
39
Antibiotics--how to use them in 1977-1978: Primary syphilis. Gonorrhea. Nongonococcal urethritis. Gonococcal dermatitis-arthritis syndrome. (628627)
1978
40
Congenital syphilis of the eye with lens involvement. (350202)
1978
41
Secondary syphilis presenting jaundice. (1215259)
1975
42
Nephrotic syndrome and secondary syphilis. (1175490)
1975
43
Congenital syphilis. (4489969)
1973
44
Glomerulopathy of congenital syphilis. (4702912)
1973
45
Histologic patterns of secondary syphilis. (4348110)
1973
46
Nephrotic syndrome: a complication of secondary syphilis. (5124440)
1971
47
Trends in cardiovascular syphilis. (13411901)
1957
48
Spinal fluid examinations among patients with primary or secondary syphilis. (14933675)
1952
49
Observations in penicillin-treated cardiovascular syphilis. (14827668)
1951
50
Penicillin in cardiovascular syphilis; early reactions to administration. (20268440)
1947

Variations for Syphilis

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Expression for genes affiliated with Syphilis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Syphilis

Search GEO for disease gene expression data for Syphilis.

Pathways for genes affiliated with Syphilis

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database
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Pathways related to Syphilis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CD40LG, CD79A
2
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.1CD40LG, CD79A, CCR5

Compounds for genes affiliated with Syphilis

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 24HMDB, 61Tocris Bioscience
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Compounds related to Syphilis according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1sulfolipid i4510.0CD79A, CD40LG
2sandoglobulin4510.0CD79A, CD40LG
3gamma globulin459.9CD79A, CD40LG
4vancomycin45 1110.9CD79A, CD40LG
5pneumococcal459.9CD79A, CD40LG
6blys459.9CD79A, CD40LG
7hydroxychloroquine45 1110.9CD40LG, APOH
8tuberculin459.9CD40LG, CD79A
9praziquantel45 1110.8CD40LG, CD79A
10hemocyanin459.8CD40LG, CD79A
11gluten459.8APOH, CD79A
12gliadin459.8CD40LG, CD79A
13pmma459.8CD79A, CD40LG
14silicone459.7CD40LG, CD79A
15okt3459.7CD79A, CD40LG
16glutaraldehyde459.7CD40LG, CD79A
17nevirapine45 51 1111.6CCR5, ABCB7
18sulfasalazine29 45 51 1112.6CD79A, CD40LG
19dextran sulfate459.5APOH, CD40LG, CCR5
20cardiolipin45 1110.5CD40LG, CD79A, APOH
21vitamin b12459.4CD79A, APOH, CD40LG
22rituximab45 51 1111.4CD79A, CD40LG, APOH
23folate459.4APOH, CD79A, CD40LG
24phosphatidylserine45 29 1111.4APOH, CD40LG, CD79A
25aspirin45 51 29 2412.4CD40LG, CD79A, APOH
26ursodeoxycholic acid45 24 1111.3CD40LG, ABCB7
27phosphorus459.3ABCB7, APOH
28thyroxine45 2410.3CD79A, ABCB7, CD40LG
29histamine45 29 2411.3CD79A, CD40LG, CCR5
30sialic acid459.2APOH, ABCB7, CD79A
31polyacrylamide459.2ABCB7, APOH, CCR5
32mannan459.2CD40LG, CD209, CD79A
33allergens459.1CD40LG, CD209, CD79A
34cyclosporin a45 29 6111.1CD40LG, CD79A, CCR5
35rantes459.1CCR5, CD209, CD40LG
36ivig459.0CCR5, APOH, CD79A, CD40LG
37galactose459.0CD79A, CD209, APOH
38arginine458.9CD79A, CD40LG, APOH, CCR5
39estrogen458.8CD40LG, CD79A, CCR5, APOH
40fibrinogen458.8APOH, CD79A, CD40LG, ABCB7
41lactate458.8CD40LG, ABCB7, APOH, CD79A
42creatinine458.8CD79A, ABCB7, APOH, CD40LG
43alanine458.8ABCB7, CCR5, CD40LG, CD79A
44pge2458.8CCR5, CD79A, CD40LG
45cocaine45 119.7CD209, CD40LG, APOH, CCR5
46polysaccharide458.7CD40LG, CD209, CD79A, CCR5
47dexamethasone45 51 29 1111.6CD209, CCR5, CD79A, CD40LG
48mannose458.6CD79A, APOH, CCR5, CD209
49heparin45 29 24 1111.4CD40LG, CD79A, CCR5, APOH, ABCB7
50glutamate458.4ABCB7, APOH, CD40LG, CD79A, CCR5

GO Terms for genes affiliated with Syphilis

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16Gene Ontology
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Cellular components related to Syphilis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1CD40LG, CD79A, CCR5

Biological processes related to Syphilis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell differentiationGO:0301839.5CD40LG, CD79A
2B cell proliferationGO:0421009.2CD40LG, CD79A
3leukocyte cell-cell adhesionGO:0071599.1CD40LG, CD209

Products for genes affiliated with Syphilis

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  • Antibodies
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Sources for Syphilis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet