MCID: SYP003
MIFTS: 48

Syphilis malady

Infectious diseases, Bone diseases, Neuronal diseases categories

Aliases & Classifications for Syphilis

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Syphilis, Aliases & Descriptions:

Name: Syphilis 9 11 43 32 3 60
 
Syphilitic Chancre 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Bone diseases, Neuronal diseases


External Ids:

Disease Ontology9 DOID:4166
MeSH33 D002601
ICD1025 A53.9

Summaries for Syphilis

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MedlinePlus:32 Syphilis is a sexually transmitted disease caused by bacteria. it infects the genital area, lips, mouth, or anus of both men and women. you usually get syphilis from sexual contact with someone who has it. it can also pass from mother to baby during pregnancy. the early stage of syphilis usually causes a single, small, painless sore. sometimes it causes swelling in nearby lymph nodes. if you do not treat it, syphilis usually causes a non-itchy skin rash, often on your hands and feet. many people do not notice symptoms for years. symptoms can go away and come back. the sores caused by syphilis make it easier to get or give someone hiv during sex. if you are pregnant, syphilis can cause birth defects, or you could lose your baby. in rare cases, syphilis causes serious health problems and even death. syphilis is easy to cure with antibiotics if you catch it early. correct usage of latex condoms greatly reduces, but does not completely eliminate, the risk of catching or spreading syphilis. nih: national institute of allergy and infectious diseases

MalaCards based summary: Syphilis, also known as syphilitic chancre, is related to hepatitis b and toxoplasmosis. An important gene associated with Syphilis is CD40LG (CD40 ligand), and among its related pathways are Primary immunodeficiency and B Cell Receptor Signaling Pathway. The drug erythromycin pwdr and the compounds sulfolipid i and sandoglobulin have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and lymph node, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Disease Ontology:9 A primary bacterial infectious disease that is a sexually transmitted systemic disease, has material basis in treponema pallidum subsp pallidum, which is transmitted by sexual contact, transmitted by blood product transfusion, transmitted by congenital method from mother to fetus or transmitted by contact with infectious lesions. if left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

CDC:3 Syphilis is an STD that can have very serious complications when left untreated.

Wikipedia:63 Syphilis is a sexually transmitted infection caused by the spirochete bacterium Treponema pallidum... more...

Related Diseases for Syphilis

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Diseases in the Syphilis family:

Secondary Syphilis Primary Syphilis
Late Congenital Syphilis Early Congenital Syphilis
Congenital Syphilis

Diseases related to Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 271)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis b30.9CCR5, ABCB7
2toxoplasmosis30.7CD40LG, CD79A
3glomerulonephritis30.6CD40LG, CD79A, CCR5
4rubella30.5CD40LG, CD79A
5hepatitis c30.5CCR5, CD40LG, ABCB7
6liver disease30.4CD79A
7chickenpox30.4CD79A
8q fever30.4CD79A
9purpura30.3CD79A
10antiphospholipid syndrome30.3APOH, CD79A, CD40LG
11lupus erythematosus30.3CD40LG, APOH, CD79A
12vasculitis30.3CD40LG, APOH, CD79A
13viral hepatitis30.2ABCB7
14behcet's disease30.0CCR5, APOH
15rheumatic disease30.0APOH, CD40LG
16systemic lupus erythematosus29.9CCR5, APOH, CD40LG, CD79A
17thrombocytopenia29.6CD79A, ABCB7, APOH, CD40LG
18rheumatoid arthritis29.5CD79A, CCR5, CD40LG, APOH
19atherosclerosis29.3CCR5, CD40LG, CD209, APOH
20congenital syphilis11.2
21secondary syphilis11.2
22primary syphilis10.9
23latent syphilis10.8
24cardiovascular syphilis10.8
25tertiary syphilis10.8
26hepatitis10.7
27yaws10.7
28early congenital syphilis10.7
29neurosyphilis10.6
30gonorrhea10.6
31late congenital syphilis10.5
32bejel10.5
33nephrotic syndrome10.4
34macroglobulinemia10.4CD79A
35cryptosporidiosis10.4CD79A
36gummatous syphilis10.4
37keratitis10.4
38interstitial keratitis10.4
39lymphogranuloma venereum10.4
40encephalitis10.3CCR5
41tonsillitis10.3
42periostitis10.3
43uveitis10.3
44leprosy10.3
45alopecia10.3
46chancroid10.3
47choroiditis10.3
48tabes dorsalis10.3
49chorioretinitis10.3
50aneurysm10.3

Graphical network of the top 20 diseases related to Syphilis:



Diseases related to syphilis

Symptoms for Syphilis

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Drugs & Therapeutics for Syphilis

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Drug clinical trials:

Search ClinicalTrials for Syphilis

Search NIH Clinical Center for Syphilis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Syphilis

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Anatomical Context for Syphilis

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MalaCards organs/tissues related to Syphilis:

31
Testes, Skin, Lymph node, Bone, Liver, Tonsil, Tongue, Eye, Spinal cord, Prostate, Heart, T cells, Spleen, Brain, Retina, Kidney, Lung, Adrenal gland, Breast, Uterus, Placenta, Temporal lobe, Trachea, Pituitary

Animal Models for Syphilis or affiliated genes

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MGI Mouse Phenotypes related to Syphilis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.6CD40LG, CD209, CCR5, APOH, ABCB7
2MP:00053766.8CD40LG, ABCB7, APOH, CCR5, CD79A, CD209

Publications for Syphilis

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Articles related to Syphilis:

(show top 50)    (show all 2070)
idTitleAuthorsYear
1
Clinical and epidemiological characteristics of males with syphilis in BiaA8ystok, Poland in 2008-2013. (25862446)
2015
2
Congenital syphilis investigation processes and timing in Louisiana. (25118972)
2014
3
The prevalence of syphilis at childbirth in Ireland: a six-year review. (24354591)
2014
4
Associated factors for HIV and syphilis infection among men who have sex with men only and men who have sex with both men and women in cities of China. (23970661)
2013
5
Predictors of serological failure after treatment in HIV-infected patients with early syphilis in the emerging Era of universal antiretroviral therapy use. (24369955)
2013
6
Usefulness of IgM-specific enzyme immunoassays for serodiagnosis of syphilis: comparative evaluation of three different assays. (23542782)
2013
7
HBsAg, anti-HCV, anti-HIV 1/2 and syphilis seroprevalence in healthy volunteer blood donors in southeastern Anatolia. (24042102)
2013
8
Human leukocyte antigen-C and killer cell immunoglobulin-like receptor gene polymorphisms among patients with syphilis in a Chinese Han population. (22958291)
2012
9
Footprint of positive selection in Treponema pallidum subsp. pallidum genome sequences suggests adaptive microevolution of the syphilis pathogen. (22720110)
2012
10
Letter to the editor: Syphilis seroreactivity: determining the importance during routine screening. (22973148)
2012
11
Syphilis: still a major cause of infant mortality. (22459083)
2012
12
Unilateral solitary choroidal granuloma as presenting sign of secondary syphilis. (21562892)
2011
13
Is it useful to perform a chest X-ray in asymptomatic patients with late latent syphilis? (21427433)
2011
14
Case of secondary syphilis presenting with unusual complications: syphilitic proctitis, gastritis, and hepatitis. (21998411)
2011
15
Circumscribed lenticular anetoderma in an HIV-infected man with a history of syphilis and lichen planus. (22031628)
2011
16
Cholestatic hepatitis and thrombocytosis in a secondary syphilis patient. (21060758)
2010
17
Primary syphilis cases in Guangdong Province 1995-2008: opportunities for linking syphilis control and regional development. (21192782)
2010
18
The Architect Syphilis assay for antibodies to Treponema pallidum: an automated screening assay with high sensitivity in primary syphilis. (18790859)
2009
19
Possible autoimmune reactions following smallpox vaccination: the biologic false positive test for syphilis. (19022322)
2009
20
Cardiovascular syphilis. (19068539)
2008
21
The outcome of treatment of early latent syphilis and syphilis with undetermined duration in HIV-infected and HIV-uninfected patients. (18073011)
2007
22
Nodular secondary syphilis mimicking cutaneous lymphoreticular process. (18032877)
2007
23
Is congenital syphilis really congenital syphilis? (17485812)
2006
24
Subclinical acquired syphilis masquerading as membranous glomerulonephritis. (17243528)
2006
25
Congenital syphilis--United States, 2002. (15306757)
2004
26
Detection of Treponema pallidum in skin lesions of secondary syphilis and characterization of the inflammatory infiltrate. (15056995)
2004
27
Incidence determinants of gonorrhea, chlamydial genital infection, syphilis and chancroid in attendees at a sexually transmitted disease clinic in Athens, Greece. (14636203)
2003
28
Sexually transmitted diseases in women. Gonorrhea and syphilis. (10689416)
2000
29
Congenital syphilis: still a reality in 1996. (8890847)
1996
30
Neonatal hypoglycemia caused by hypopituitarism in infants with congenital syphilis. (8229534)
1993
31
Distinguishing beta 2-glycoprotein I dependent (systemic lupus erythematosus type) and independent (syphilis type) anticardiolipin antibody with Tween 20. (7918046)
1993
32
Granulomatous hepatitis in secondary syphilis. (2189840)
1990
33
Sexually transmitted diseases and native Americans: trends in reported gonorrhea and syphilis morbidity, 1984-88. (2511589)
1989
34
Leads from the MMWR. Syphilis and congenital syphilis--United States, 1985-1988. (3411729)
1988
35
Repair of a palatal defect associated with late congenital syphilis using a tongue flap. (3276855)
1988
36
Transverse myelitis due to meningovascular syphilis. (6696656)
1984
37
Physicians' recognition of the signs and symptoms of secondary syphilis. (7241768)
1981
38
Secondary syphilis with iris papules. (7191640)
1980
39
Bell's palsy and secondary syphilis: CSF spirochetes detected by immunofluorescence. (365078)
1978
40
Antibiotics--how to use them in 1977-1978: Primary syphilis. Gonorrhea. Nongonococcal urethritis. Gonococcal dermatitis-arthritis syndrome. (628627)
1978
41
Secondary syphilis presenting jaundice. (1215259)
1975
42
Nephrotic syndrome and secondary syphilis. (1175490)
1975
43
Congenital syphilis. (4489969)
1973
44
Glomerulopathy of congenital syphilis. (4702912)
1973
45
Histologic patterns of secondary syphilis. (4348110)
1973
46
Nephrotic syndrome: a complication of secondary syphilis. (5124440)
1971
47
Trends in cardiovascular syphilis. (13411901)
1957
48
Spinal fluid examinations among patients with primary or secondary syphilis. (14933675)
1952
49
Observations in penicillin-treated cardiovascular syphilis. (14827668)
1951
50
Penicillin in cardiovascular syphilis; early reactions to administration. (20268440)
1947

Variations for Syphilis

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Expression for genes affiliated with Syphilis

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Search GEO for disease gene expression data for Syphilis.

Pathways for genes affiliated with Syphilis

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Pathways related to Syphilis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CD40LG, CD79A
2
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.1CD40LG, CD79A, CCR5

Compounds for genes affiliated with Syphilis

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Compounds related to Syphilis according to GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1sulfolipid i4310.0CD79A, CD40LG
2sandoglobulin4310.0CD79A, CD40LG
3gamma globulin439.9CD79A, CD40LG
4vancomycin43 1210.9CD79A, CD40LG
5pneumococcal439.9CD79A, CD40LG
6blys439.9CD79A, CD40LG
7hydroxychloroquine43 1210.9CD40LG, APOH
8tuberculin439.9CD40LG, CD79A
9praziquantel43 1210.8CD40LG, CD79A
10hemocyanin439.8CD40LG, CD79A
11gluten439.8APOH, CD79A
12gliadin439.8CD40LG, CD79A
13pmma439.8CD79A, CD40LG
14silicone439.7CD40LG, CD79A
15okt3439.7CD79A, CD40LG
16glutaraldehyde439.7CD40LG, CD79A
17nevirapine43 49 1211.6CCR5, ABCB7
18sulfasalazine28 43 49 1212.6CD79A, CD40LG
19dextran sulfate439.5APOH, CD40LG, CCR5
20cardiolipin43 1210.5CD40LG, CD79A, APOH
21vitamin b12439.4CD79A, APOH, CD40LG
22rituximab43 49 1211.4CD79A, CD40LG, APOH
23folate439.4APOH, CD79A, CD40LG
24phosphatidylserine43 28 1211.4APOH, CD40LG, CD79A
25aspirin43 49 28 2412.4CD40LG, CD79A, APOH
26ursodeoxycholic acid43 24 1211.3CD40LG, ABCB7
27phosphorus439.3ABCB7, APOH
28thyroxine43 2410.3CD79A, ABCB7, CD40LG
29histamine43 28 2411.3CD79A, CD40LG, CCR5
30sialic acid439.2APOH, ABCB7, CD79A
31polyacrylamide439.2ABCB7, APOH, CCR5
32mannan439.2CD40LG, CD209, CD79A
33allergens439.1CD40LG, CD209, CD79A
34cyclosporin a43 28 5911.1CD40LG, CD79A, CCR5
35rantes439.1CCR5, CD209, CD40LG
36ivig439.0CCR5, APOH, CD79A, CD40LG
37galactose439.0CD79A, CD209, APOH
38arginine438.9CD79A, CD40LG, APOH, CCR5
39estrogen438.8CD40LG, CD79A, CCR5, APOH
40fibrinogen438.8APOH, CD79A, CD40LG, ABCB7
41lactate438.8CD40LG, ABCB7, APOH, CD79A
42creatinine438.8CD79A, ABCB7, APOH, CD40LG
43alanine438.8ABCB7, CCR5, CD40LG, CD79A
44pge2438.8CCR5, CD79A, CD40LG
45cocaine43 129.7CD209, CD40LG, APOH, CCR5
46polysaccharide438.7CD40LG, CD209, CD79A, CCR5
47dexamethasone43 49 28 1211.6CD209, CCR5, CD79A, CD40LG
48mannose438.6CD79A, APOH, CCR5, CD209
49heparin43 28 24 1211.4CD40LG, CD79A, CCR5, APOH, ABCB7
50glutamate438.4ABCB7, APOH, CD40LG, CD79A, CCR5

GO Terms for genes affiliated with Syphilis

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Cellular components related to Syphilis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.1CD40LG, CD79A, CCR5

Biological processes related to Syphilis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1B cell differentiationGO:00301839.5CD40LG, CD79A
2B cell proliferationGO:00421009.2CD40LG, CD79A
3leukocyte cell-cell adhesionGO:00071599.1CD40LG, CD209

Products for genes affiliated with Syphilis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Syphilis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet