MCID: SYP003
MIFTS: 55

Syphilis malady

Infectious category

Summaries for Syphilis

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Syphilis is a sexually transmitted disease caused by bacteria. it infects the genital area, lips, mouth, or anus of both men and women. you usually get syphilis from sexual contact with someone who has it. it can also pass from mother to baby during pregnancy. the early stage of syphilis usually causes a single, small, painless sore. sometimes it causes swelling in nearby lymph nodes. if you do not treat it, syphilis usually causes a non-itchy skin rash, often on your hands and feet. many people do not notice symptoms for years. symptoms can go away and come back. the sores caused by syphilis make it easier to get or give someone hiv during sex. if you are pregnant, syphilis can cause birth defects, or you could lose your baby. in rare cases, syphilis causes serious health problems and even death. syphilis is easy to cure with antibiotics if you catch it early. correct usage of latex condoms greatly reduces, but does not completely eliminate, the risk of catching or spreading syphilis. nih: national institute of allergy and infectious diseases

MalaCards: Syphilis, also known as syphilis, unspecified, is related to primary syphilis and hepatitis c. An important gene associated with Syphilis is CD40LG (CD40 ligand), and among its related pathways are Primary immunodeficiency and B cell receptor signaling pathway. The drug erythromycin pwdr and the compounds sulfolipid i and sandoglobulin have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and spleen, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Disease Ontology:8 A primary bacterial infectious disease that is a sexually transmitted systemic disease, has material basis in treponema pallidum subsp pallidum, which is transmitted by sexual contact, transmitted by blood product transfusion, transmitted by congenital method from mother to fetus or transmitted by contact with infectious lesions. if left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

CDC:3 The sexual behaviors that spread syphilis also spread other STDs, like HIV.

Wikipedia:64 Syphilis is a sexually transmitted infection caused by the spirochete bacterium Treponema pallidum... more...

Aliases & Classifications for Syphilis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 35MeSH, 57SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

syphilis 8 10 45 34 61
syphilis, unspecified 8
syphilitic chancre 8
syphilis nos 8


External Ids:

Disease Ontology8 DOID:4166
MeSH35 D002601
ICD1025 A53.9

Related Diseases for Syphilis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the late congenital syphilis family:

early congenital syphilis primary syphilis
congenital syphilis syphilis

Diseases related to Syphilis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 254)
idRelated DiseaseScoreTop Affiliating Genes
1primary syphilis31.4ZBTB32, PDE6D
2hepatitis c30.7CCR5, CD40LG, ABCB7
3uveitis30.4CCR5
4hepatitis b30.4FN1, CD79A, ABCB7
5toxoplasmosis30.3CD79A, CD40LG
6arthritis30.3CCR5, FN1
7tuberculosis30.3FN1, CD79A, CD209, CP
8antiphospholipid syndrome30.2APOH, CD40LG, CD79A
9acquired immunodeficiency syndrome30.1CCR5
10rubella30.1CD79A, CD40LG
11vasculitis30.1APOH, FN1, CD40LG, CD79A
12systemic lupus erythematosus30.1CCR5, APOH, CD40LG, CD79A
13thrombocytopenia29.9ABCB7, CD79A, CD40LG, APOH
14leptospirosis29.7CD40LG, FN1
15viral hepatitis29.7ABCB7, FN1
16toxocariasis29.7TES
17infectious mononucleosis29.7CD40LG, CD79A
18behcet's disease29.7CCR5, APOH, CP
19atherosclerosis29.7CCR5, APOH, FN1, CD40LG, CD209, CP
20secondary syphilis11.2
21latent syphilis10.8
22tertiary syphilis10.8
23cardiovascular syphilis10.8
24early congenital syphilis10.7
25yaws10.7
26neurosyphilis10.6
27gonorrhea10.6
28late congenital syphilis10.6
29bejel10.4
30hepatitis a10.4
31n syndrome10.4
32gummatous syphilis10.4
33lymphogranuloma venereum10.3
34hepatitis e10.3
35tabes dorsalis10.2
36hepatitis d10.2
37chancroid10.2
38alopecia10.2
39lichen planus10.2
40hepatitis c virus10.2
41erythema multiforme10.2
42asymptomatic neurosyphilis10.2
43lyme disease10.2
44hydrops fetalis10.2
45syphilitic aseptic meningitis10.2
46treponema infection10.2
47membranous glomerulonephritis10.0
48iritis10.0
49pityriasis rosea10.0
50neuroretinitis10.0

Graphical network of the top 20 diseases related to Syphilis:



Diseases related to syphilis

Clinical Features for Syphilis

Drugs & Therapeutics for Syphilis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Syphilis

Drug clinical trials:

Search ClinicalTrials for Syphilis

Search NIH Clinical Center for Syphilis

Search CenterWatch for Syphilis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Syphilis

Anatomical Context for Syphilis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Syphilis:

33
Whole blood, Lymph node, Spleen, Brain, Retina, Spinal cord, Heart, Small intestine, Kidney, Liver, Lung, Adrenal gland, Breast, Skin, Uterus, Placenta, Prostate, Tonsil, T cells, B cells, Fetal brain, Temporal lobe, Tongue, Fetal liver, Fetal lung, Trachea, Pituitary

Animal Models for Syphilis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Syphilis

Sources:
51PubMed
See all sources

Articles related to Syphilis:

(show top 50)    (show all 2002)
idTitleAuthorsYear
1
MyD88 deficiency markedly worsens tissue inflammation and bacterial clearance in mice infected with Treponema pallidum, the agent of syphilis. (23940747)
2013
2
Syphilis in the modern era: an update for physicians. (24275265)
2013
3
Ocular syphilis. (24030333)
2013
4
Response to therapy following retreatment of serofast early syphilis patients with benzathine penicillin. (23118269)
2013
5
Late latent syphilis in two hemodialysis units. (23354207)
2013
6
Behcet's disease simulating secondary syphilis in an HIV-infected patient. (23919062)
2013
7
Hospitalization cost of congenital syphilis diagnosis from insurance claims data in the United States. (23407468)
2013
8
False-negative anti-treponemal immunohistochemistry in secondary syphilis. (22417052)
2013
9
The effect of a structural intervention for syphilis control among 3597 female sex workers: a demonstration study in South China. (22807520)
2012
10
Multilevel and spatial analysis of syphilis in Shenzhen, China, to inform spatially targeted control measures. (22378936)
2012
11
Clarithromycin treatment failure due to macrolide resistance in Treponema pallidum in a patient with primary syphilis. (20169316)
2010
12
Syphilis mimicking tinea imbricata and erythema annulare centrifugum in an immunocompromised patient. (19539866)
2009
13
A systematic review of pediatric sensorineural hearing loss in congenital syphilis. (19321207)
2009
14
Male patient with a genital ulceration. Primary syphilis. (18246892)
2008
15
Decreased congenital syphilis incidence in Haiti's rural Artibonite region following decentralized prenatal screening. (12604493)
2003
16
Congenital syphilis: subtle presentation of fulminant disease. (9039217)
1997
17
Distinguishing beta 2-glycoprotein I dependent (systemic lupus erythematosus type) and independent (syphilis type) anticardiolipin antibody with Tween 20. (7918046)
1993
18
Congenital syphilis: old disease, new resurgence. (1545326)
1992
19
Presence of IgE class antibodies with cardiolipinic and treponemal specificity in syphilis. Quantitative evaluation by IgE prist radio-immuno-assay. (1457821)
1992
20
Congenital syphilis. (2343358)
1990
21
Prevalence of gonorrhoea, syphilis and trichomoniasis in prostitutes in Burkina Faso. (2226226)
1990
22
Congenital syphilis--a plea for prevention. (3420474)
1988
23
Changes in intravascular complement, kininogen, and histamine during Jarisch-Herxheimer reaction in secondary syphilis. (3878826)
1985
24
Periostitis in secondary syphilis: a place for bone scintigraphy. (4045902)
1985
25
Sexually transmitted diseases. Secondary syphilis. (7083907)
1982
26
Congenital syphilis: an unusual presentation. (7403512)
1980
27
Value of bone roentgenograms in diagnosis. Congenital syphilis with unusual clinical presentations. (16848)
1977
28
The role of surgery in primary syphilis of the anus. (938119)
1976
29
Congenital syphilis after maternal treatment with erythromycin. (943741)
1976
30
Letter: Behavior of the complement system in the nephropathy of congenital syphilis. (1249704)
1976
31
Nephrotic syndrome and secondary syphilis. (1175490)
1975
32
The FTA-ABS test in dark-field-positive primary syphilis. (4595670)
1974
33
Primary syphilis of rectum. (4530911)
1974
34
Acute periostitis in early acquired syphilis. (4762423)
1973
35
Physiologic changes during the Jarisch-Herxheimer reaction in early syphilis. A comparison with louse-borne relapsing fever. (5095525)
1971
36
Primary and secondary syphilis. Country of origin study, 1967. Britisch Cooperative Clinical Group. (5708225)
1968
37
The treponemal complement-fixation tests in probable latent syphilis or biologic false positive reactions. (13549800)
1958
38
Trends in cardiovascular syphilis. (13411901)
1957
39
Treponema-immobilizing antibodies in syphilis. I. Principle and risks in their determination; their effect on the biology of treponemas; respective roles of treponema infection and secondary reactions in syphilitic disease]. (13444756)
1957
40
Cardiovascular syphilis. (14367862)
1955
41
The relation of lymphogranuloma venereum to syphilis and to falsely positive serologic tests for syphilis. (13189036)
1954
42
Fever in early congenital syphilis. (13196895)
1954
43
Studies in pallesthesia; quantitative vibratory levels in syphilis and in lymphogranuloma venereum. (13080558)
1953
44
Mass treatment of treponemal diseases, with particular reference to syphilis and yaws. (13019137)
1953
45
Studies on the comparative behavior of various serologic tests for syphilis. J. A report on serologic findings among patients with primary syphilis at beginning of therapy. (14874329)
1951
46
Treatment of cardiovascular syphilis. (18123211)
1949
47
Cardiovascular syphilis. (18876793)
1948
48
Treatment of cardiovascular syphilis. (18869862)
1948
49
The incidence of multiple lesions in primary syphilis. (18902952)
1948
50
Early Diagnosis of Primary Syphilis : Practical Darkfield Examination by Mail. (18014117)
1934

Genetic Variations for Syphilis

Expression for genes affiliated with Syphilis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Syphilis

Search GEO for disease gene expression data for Syphilis.

Pathways for genes affiliated with Syphilis

Sources:
30KEGG, 38NCBI BioSystems Database
See all sources

Pathways related to Syphilis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0IKBKG, CD79A, CD40LG
2
Hide members
9.9IKBKG, CD79A, CD40LG, CCR5

Compounds for genes affiliated with Syphilis

Sources:
45Novoseek, 24HMDB, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Syphilis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1sulfolipid i4510.6CD79A, CD40LG
2sandoglobulin4510.6CD40LG, CD79A
3gluten4510.5CD79A, APOH
4uric acid45 2411.5ABCB7, APOH
5mannan4510.5CD209, CD79A, CD40LG
6pmma4510.5CD79A, CD40LG, FN1
7silicone4510.4FN1, CD40LG, CD79A
8cardiolipin45 1111.4CD79A, CD40LG, APOH
9vancomycin45 1111.4CD40LG, CD79A
10cytidine45 11 2412.4IKBKG, CD79A, CD40LG
11anti-fungal4510.4PPIB, CD40LG, CD79A
12phenytoin45 50 29 1113.4CD40LG, CD79A, CP
13rituximab45 50 1112.4APOH, CD40LG, CD79A
14ivig4510.4CD79A, CD40LG, APOH, CCR5
15dextran sulfate4510.4CCR5, APOH, FN1, CD40LG
16allergens4510.3CD209, CD79A, CD40LG
17cocaine45 1111.3CCR5, APOH, CD40LG, CD209
18pneumococcal4510.3CD40LG, CD79A
19betacarotene4510.3CP, CD79A, APOH
20vitamin b124510.3APOH, CD40LG, CD79A, CP
21mannose4510.3CCR5, APOH, CD79A, CD209
22polyethylene glycol4510.3CD79A, CD40LG, FN1
23sialic acid4510.3APOH, CD79A, ABCB7, CP
24blys4510.3CD40LG, CD79A
25thyroxine45 2411.3CD40LG, CD79A, ABCB7, CP
26folate4510.2APOH, CD40LG, CD79A, CP
27polyacrylamide4510.2CCR5, APOH, FN1, ABCB7
28aspirin45 50 29 2413.2CD79A, CD40LG, FN1, APOH
29hydroxychloroquine45 1111.2APOH, CD40LG
30vitamin-e4510.2CCR5, ABCB7, CP
31tuberculin4510.2CD79A, CD40LG
32polysaccharide4510.2CCR5, FN1, CD40LG, CD79A, CD209
33agar4510.2FN1, CD40LG, CD79A, CP
34galactose4510.1CD209, CD79A, APOH
35indomethacin45 60 29 1113.1FN1, CD40LG, CD79A, CP
36cyclosporin a45 29 6012.1CD79A, CD40LG, FN1, PPIB, CCR5
37vitamin d4510.0CP, CD79A, FN1, CCR5
38fibrinogen4510.0APOH, FN1, CD40LG, CD79A, ABCB7, CP
39lactate4510.0APOH, FN1, CD40LG, CD79A, ABCB7, CP
40creatinine4510.0APOH, FN1, CD40LG, CD79A, ABCB7, CP
41latex459.9FN1, APOH, CCR5
42dexamethasone45 50 29 1112.9CCR5, FN1, CD40LG, CD79A, CD209, CP
43alanine459.9CCR5, FN1, CD40LG, CD79A, ABCB7, CP
44zinc45 2410.9CCR5, APOH, ZBTB32, IKBKG, ABCB7, CP
45glutamate459.8CCR5, NLRP12, APOH, CD40LG, CD79A, ABCB7
46estrogen459.8CCR5, NLRP12, APOH, FN1, CD40LG, CD79A
47cysteine459.7CCR5, NLRP12, FN1, CD40LG, CD79A, CP
48biotin45 11 2411.7FN1, CD40LG, CD79A
49heparin45 29 11 2412.7CP, CCR5, APOH, PPIB, FN1, CD40LG
50arginine459.7CCR5, NLRP12, APOH, FN1, CD40LG, CD79A

GO Terms for genes affiliated with Syphilis

Sources:
16Gene Ontology
See all sources

Biological processes related to Syphilis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:04210010.2CD79A, CD40LG

Products for genes affiliated with Syphilis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Syphilis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet