MCID: SYP003
MIFTS: 55

Syphilis

Categories: Infectious diseases, Rare diseases, Bone diseases, Neuronal diseases

Aliases & Classifications for Syphilis

Summaries for Syphilis

MedlinePlus : 40 Syphilis is a sexually transmitted disease caused by bacteria. It infects the genital area, lips, mouth, or anus of both men and women. You usually get syphilis from sexual contact with someone who has it. It can also pass from mother to baby during pregnancy. The early stage of syphilis usually causes a single, small, painless sore. Sometimes it causes swelling in nearby lymph nodes. If you do not treat it, syphilis usually causes a non-itchy skin rash, often on your hands and feet. Many people do not notice symptoms for years. Symptoms can go away and come back. The sores caused by syphilis make it easier to get or give someone HIV during sex. If you are pregnant, syphilis can cause complications, or you could lose your baby. In rare cases, syphilis causes serious health problems and even death. Syphilis is easy to cure with antibiotics if you catch it early. Correct usage of latex condoms greatly reduces, but does not completely eliminate, the risk of catching or spreading syphilis. The most reliable way to avoid infection is to not have anal, vaginal, or oral sex. Centers for Disease Control and Prevention

MalaCards based summary : Syphilis, also known as chancre, is related to early congenital syphilis and tertiary syphilis, and has symptoms including syphilitic chancre, gummatous inflammation and pruritus. An important gene associated with Syphilis is APOH (Apolipoprotein H), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Penicillin G and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and heart, and related phenotype is homeostasis/metabolism.

Disease Ontology : 12 A primary bacterial infectious disease that is a sexually transmitted systemic disease, has material basis in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

CDC : 3 You should get tested regularly if you are pregnant, are a man who has sex with men, have HIV infection, and/or have partner(s) who have tested positive for syphilis.

Wikipedia : 72 Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies... more...

Related Diseases for Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 373)
# Related Disease Score Top Affiliating Genes
1 early congenital syphilis 34.0 CD40LG MYH9
2 tertiary syphilis 33.6 CD40LG EXTL3 MYH9
3 congenital syphilis 33.5 CD40LG CD79A EXTL3 MYH9
4 primary syphilis 33.5 CD40LG EXTL3 MYH9
5 latent syphilis 32.6 CD40LG EXTL3 MYH9 TPR
6 secondary syphilis 32.3 CD209 CD40LG CD79A EXTL3 TPR
7 tertiary neurosyphilis 32.1 CD40LG CD79A EXTL3 MYH9
8 tabes dorsalis 32.0 CD79A EXTL3
9 antiphospholipid syndrome 30.4 APOH CD40LG CD79A
10 vasculitis 30.3 APOH CD40LG CD79A
11 yaws 30.3 EXTL3 TPR
12 asymptomatic neurosyphilis 30.3 CD40LG CD79A EXTL3 MYH9
13 acquired immunodeficiency syndrome 30.3 B2M CD40LG CD79A
14 sporotrichosis 30.2 CD40LG CD79A
15 leprosy 3 30.2 CD209 CD40LG CD79A
16 chorioretinitis 30.2 CD40LG CD79A EXTL3
17 meningovascular neurosyphilis 30.1 CD40LG CD79A
18 amebiasis 29.8 CD40LG CD79A
19 purpura 29.8 APOH CD40LG CD79A
20 meningoencephalitis 29.8 B2M CD40LG CD79A
21 urethritis 29.8 CD40LG CD79A EXTL3
22 trichomoniasis 29.8 CD79A EXTL3
23 syphilitic meningitis 29.7 CD40LG EXTL3
24 early yaws 29.4 CD40LG CD79A EXTL3
25 cardiovascular syphilis 12.4
26 late congenital syphilis 12.3
27 gummatous syphilis 12.2
28 bejel 12.0
29 neurosyphilis 11.8
30 syphilitic aseptic meningitis 11.8
31 aortic aneurysm, familial thoracic 1 11.3
32 paroxysmal cold hemoglobinuria 11.3
33 pinta disease 11.2
34 chronic rhinitis 10.8
35 idiopathic hypertrophic pachymeningitis 10.8
36 progressive locomotor ataxia 10.8
37 syphilitic spinal sclerosis 10.8
38 selective igg deficiency disease 10.6 CD40LG CD79A
39 c1q nephropathy 10.6 CD40LG CD79A
40 alpha chain disease 10.6 CD40LG CD79A
41 brill-zinsser disease 10.6 CD40LG CD79A
42 exudative glomerulonephritis 10.6 CD40LG CD79A
43 cork-handlers' disease 10.6 CD40LG CD79A
44 salpingo-oophoritis 10.6 CD40LG CD79A
45 ventilation pneumonitis 10.6 CD40LG CD79A
46 chronic interstitial cystitis 10.6 CD40LG CD79A
47 axillary adenitis 10.6 CD40LG CD79A
48 cryofibrinogenemia 10.6 CD40LG CD79A
49 borderline leprosy 10.6 APOH CD40LG
50 trichostrongyloidiasis 10.6 CD40LG CD79A

Comorbidity relations with Syphilis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Hypertension, Essential Schizophreniform Disorder

Graphical network of the top 20 diseases related to Syphilis:



Diseases related to Syphilis

Symptoms & Phenotypes for Syphilis

UMLS symptoms related to Syphilis:


syphilitic chancre, gummatous inflammation, pruritus, pelvic pain, fever

MGI Mouse Phenotypes related to Syphilis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.32 B2M CAT CD40LG CD79A EXTL3 FAS

Drugs & Therapeutics for Syphilis

Drugs for Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 95)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin G Approved, Vet_approved Phase 4,Phase 3 61-33-6 5904
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Early Phase 1 564-25-0 54671203
3
Procaine Approved, Investigational, Vet_approved Phase 4,Phase 3 59-46-1 4914
4
Emtricitabine Approved, Investigational Phase 4,Phase 3,Phase 2 143491-57-0 60877
5 Anti-Bacterial Agents Phase 4,Phase 3,Early Phase 1
6 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
7
Tenofovir Phase 4,Phase 3,Phase 2 147127-20-6 464205
8 penicillins Phase 4,Phase 3
9 Reverse Transcriptase Inhibitors Phase 4,Phase 3
10 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3
11 Penicillin G Benzathine Phase 4,Phase 3
12 Penicillin G Procaine Phase 4,Phase 3
13 Anti-HIV Agents Phase 4,Phase 3,Phase 2
14 Antimalarials Phase 4,Phase 3,Early Phase 1
15 Anti-Retroviral Agents Phase 4,Phase 3,Phase 2
16 Antiprotozoal Agents Phase 4,Phase 3,Early Phase 1
17 Antiparasitic Agents Phase 4,Phase 3,Early Phase 1
18 Antiviral Agents Phase 4,Phase 3,Phase 2
19
Heroin Approved, Illicit, Investigational Phase 3 561-27-3 5462328
20
Methadone Approved Phase 3 76-99-3 4095
21
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
22
Azithromycin Approved Phase 3 83905-01-5 53477736 447043 55185
23
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
24
Adalimumab Approved Phase 3 331731-18-1 16219006
25
Pyrimethamine Approved, Investigational, Vet_approved Phase 3 58-14-0 4993
26
Sulfadoxine Approved, Investigational Phase 3 2447-57-6 17134
27
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
28
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
29
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
30 Analgesics Phase 3
31 Respiratory System Agents Phase 3
32 Central Nervous System Depressants Phase 3
33 Chlorpheniramine, phenylpropanolamine drug combination Phase 3
34 Narcotics Phase 3
35 Vaccines Phase 3,Phase 2
36 Analgesics, Opioid Phase 3
37 Peripheral Nervous System Agents Phase 3,Phase 1,Phase 2
38 Antitussive Agents Phase 3
39 Analgesics, Non-Narcotic Phase 3
40 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 3
41 Anti-Inflammatory Agents Phase 3
42 Anti-Inflammatory Agents, Non-Steroidal Phase 3
43 Antirheumatic Agents Phase 3
44 mometasone furoate Phase 3
45 Folic Acid Antagonists Phase 3
46 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
47 Dermatologic Agents Phase 3
48 Vitamin B Complex Phase 3
49 Immunosuppressive Agents Phase 3
50 Antimetabolites Phase 3

Interventional clinical trials:

(show top 50) (show all 124)

# Name Status NCT ID Phase Drugs
1 Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
2 Serological Response to Retreatment of Serofast Early Syphilis Cases With Benzathine Penicillin Recruiting NCT02884115 Phase 4 benzathine penicillin
3 One Dose Versus Three Weekly Doses of Benzathine Penicillin G for Patients With Early Syphilis Recruiting NCT02857959 Phase 4 Benzathine Penicillin G
4 The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings Recruiting NCT02871505 Phase 4 Benzathine Penicillin G
5 PrEP Implementation for Mothers in Antenatal Care Recruiting NCT03070600 Phase 4 Universal PrEP Counseling;Targeted PrEP Counseling
6 Tenofovir/Emtricitabine With Doxycycline for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative MSM Not yet recruiting NCT02844634 Phase 4 Doxycycline 100mg PO daily x 12 months;Tenofovir/emtricitabine 200/300mg PO daily;Doxycycline 100mg PO daily x 6 months
7 Introduction Study of Dual HIV & Syphilis Rapid Diagnostic Tests in Antenatal Clinics in Colombia Unknown status NCT02454816 Phase 2, Phase 3
8 (Men Who Have Sex With Men) MSM Community Intervention Trial Unknown status NCT01068015 Phase 3
9 Injecting Drug Use Community Intervention Trial Unknown status NCT01108614 Phase 3
10 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
11 Azithromycin/Bicillin Syphilis Completed NCT00031499 Phase 3 Azithromycin;Benzathine Penicillin;Doxycycline
12 Male Circumcision for HIV Prevention in Rakai, Uganda Completed NCT00425984 Phase 3
13 Single-dose Azithromycin for the Treatment of Yaws Completed NCT01382004 Phase 3 Penicillin-G-benzathine;Azithromycin
14 Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission Completed NCT00213083 Phase 3 Carraguard (PC-515)
15 Effectiveness of a Community-level HIV/STD Prevention Intervention in Promoting Safer Sexual Behaviors in High-risk Populations Completed NCT00710060 Phase 3
16 Emtricitabine/Tenofovir Disoproxil Fumarate for HIV Prevention in Men Completed NCT00458393 Phase 3 daily TDF/FTC;Placebo
17 MEMA Kwa Vijana Trial: Impact of an Adolescent Sexual and Reproductive Health Intervention in Mwanza, Tanzania Completed NCT00248469 Phase 3
18 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
19 Expanded PrEP Implementation in Communities in NSW Recruiting NCT02870790 Phase 3 TDF/FTC
20 Protecting From Pneumococcus in Early Life (The PROPEL Trial) Recruiting NCT02628886 Phase 3
21 Evaluation of the Effectiveness and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo, in Subjects With Rheumatoid Arthritis (RA) Who Are Taking an Existing Medication Called a Tumour Necrosis Factor Alpha Inhibitor But Have Active Di Recruiting NCT02760433 Phase 3 Olokizumab q4w;Olokizumab q2w;Placebo q2w
22 Evaluation of the Long Term Safety, Tolerability and Efficacy of Two Dosing Regimens of Olokizumab (OKZ), in Subjects With Rheumatoid Arthritis (RA) Who Previously Completed 24 Weeks of Blinded Treatment in One of the Core Studies - CREDO 1, 2 or 3. Recruiting NCT03120949 Phase 3 Olokizumab 64 mg SC q4w;Olokizumab 64 mg SC q2w;Methotrexate
23 Evaluation of the Effectiveness and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo and Adalimumab, in Subjects With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate But Have Active Disease Recruiting NCT02760407 Phase 3 Olokizumab 64mg q4w;Olokizumab 64mg q2w;Adalimumab 40mg q2w;Placebo q2w
24 Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy Recruiting NCT01901094 Phase 3
25 Western Australian Pre-exposure Prophylaxis for HIV Implementation Trial Not yet recruiting NCT03327155 Phase 3 Tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC)
26 Improving PRegnancy Outcomes With Intermittent preVEntive Treatment in Africa Not yet recruiting NCT03208179 Phase 3 dihydroartemisinin-piperaquine;sulphadoxine-pyrimethamine;dihydroartemisinin-piperaquine plus azithromycin
27 Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa Terminated NCT01103063 Phase 3 Azithromycin plus chloroquine;sulfadoxine-pyrimethamine
28 Effectiveness of the Diaphragm for HIV Prevention Withdrawn NCT00121459 Phase 3
29 Safety, Acceptability and Preliminary Effectiveness of Carraguard™ (PC-515) in Preventing HIV/STI Transmission Completed NCT00213018 Phase 2 Carraguard (PC-515)
30 Safety, Acceptability and Preliminary Effectiveness of PC-515 for Vaginal Use as a Possible Microbicide Completed NCT00213031 Phase 2 Carraguard (PC-515)
31 Behavioral Intervention to Reduce Sexual and Injection Risks Among Female Sex Workers Who Also Inject Drugs in Mexico Completed NCT00840658 Phase 2
32 A Web-based Intervention Study to Reduce High-risk Sexual Behavior by Persons Living With HIV AIDS (PLWH) Completed NCT01198418 Phase 1, Phase 2
33 Lay Health Advisors for Sexually Transmitted Disease Prevention Completed NCT00207506 Phase 1, Phase 2
34 Safety and Efficacy Study of Human Autologous Hair Follicle Cells to Treat Androgenetic Alopecia Completed NCT01286649 Phase 1, Phase 2
35 Development of a Methamphetamine Early Intervention Completed NCT01174654 Phase 1, Phase 2
36 A Tolerability and Efficacy Study of TU-100 For The Treatment of Postoperative Ileus Completed NCT00266461 Phase 2 Daikenchuto Extract Granules (TU-100)
37 BufferGel and PRO 2000/5: Vaginal Gels to Prevent HIV Infection in Women Completed NCT00074425 Phase 2 BufferGel;PRO 2000/5 Gel;Placebo gel
38 Safer Sex Program for Young African-American Men Recruiting NCT01439503 Phase 2
39 Optimizing the Delivery of HIV nPEP Not yet recruiting NCT03259698 Phase 2 nPEP
40 Development of Immune Globulin Treatment for Avian Flu Terminated NCT00383071 Phase 2
41 Infections and Autoimmunity: Autobodies Screening in Multiple Sclerosis Unknown status NCT00230204 Phase 1
42 Computer-Assisted Tailored Cue-card Health [CATCH] Study Completed NCT01170741 Phase 1
43 Fecal Microbiota Transplantation in Pediatric Patients Completed NCT02108821 Phase 1
44 Safety and Acceptability of Carraguard™ Among HIV-negative Couples in Thailand Completed NCT00213057 Phase 1 Carraguard (PC-515)
45 Syphilis Treatment of Partners Trial Unknown status NCT02262390
46 A Methadone Maintenance Treatment Outcome Study in Three Provinces in China Unknown status NCT01315054
47 Human Papillomavirus Infection and Knowledge and Attitudes About HPV Vaccines Among Men Who Have Sex With Men (MSM) Unknown status NCT01300689
48 Healthy Beginning Initiative Unknown status NCT01795261
49 The Impact of Short-term Financial Incentives on Sexual Behavior and HIV Incidence in Lesotho Unknown status NCT01589965 Early Phase 1
50 Illness Crisis Adapting in Early or Middle Phase of Patient With Chronic Disease: Study of Meta-cognition Model Unknown status NCT01964612

Search NIH Clinical Center for Syphilis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: chancre

Genetic Tests for Syphilis

Anatomical Context for Syphilis

MalaCards organs/tissues related to Syphilis:

38
Testes, Skin, Heart, Lymph Node, Bone, Liver, Tonsil

Publications for Syphilis

Articles related to Syphilis:

(show top 50) (show all 2379)
# Title Authors Year
1
Social networks as drivers of syphilis and HIV infection among young men who have sex with men. ( 29440465 )
2018
2
HIV and syphilis epidemic among MSM and non-MSM aged 50 and above in Shanghai, China: A yearly cross-sectional study, 2008-2014. ( 29419357 )
2018
3
Image Gallery: A case of malignant syphilis in an HIV-infected patient mimicking fungal infection. ( 29357605 )
2018
4
Syphilis in the Setting of Anti-tumor Necrosis Factor Alpha Therapy. ( 29398464 )
2018
5
Presence of dental signs of congenital syphilis in pre-modern specimens. ( 29102860 )
2018
6
Factors associated with HIV co-infection in cases of acquired syphilis reported in a Reference Center for Sexually Transmitted Diseases and AIDS in the municipality of SALo Paulo, Brazil, 2014. ( 29451611 )
2018
7
Mucocutaneous Secondary Syphilis: 'The Great Imitator'. ( 29079400 )
2018
8
Secondary Syphilis Without Any History of Primary Infection. ( 29366456 )
2018
9
Secondary Syphilis with Pulmonary Involvement. ( 29021433 )
2018
10
A secondary syphilis rash with scaly target lesions. ( 29410787 )
2018
11
An Application of Syndemic Theory to Identify Drivers of the Syphilis Epidemic Among Gay, Bisexual, and Other Men Who Have Sex With Men. ( 29420444 )
2018
12
Rapid Increase in Reports of Syphilis Associated With Men Who Have Sex With Women and Women Who Have Sex With Men, Japan, 2012 to 2016. ( 29420439 )
2018
13
Challenges in the management of syphilis in pregnancy: completing a multicentre audit cycle with mixed outcomes. ( 29409434 )
2018
14
Syphilis in Children. ( 29406973 )
2018
15
Serological response to therapy following retreatment of serofast early syphilis patients with benzathine penicillin. ( 29394361 )
2018
16
Analysis of cases of gestational and congenital syphilis between 2008 and 2010 in Fortaleza, State of CearA!, Brazil. ( 29412414 )
2018
17
Primary and Secondary Syphilis as Chancre of the Mouth with Rash. ( 29033418 )
2018
18
Factors Associated With Syphilis Testing and a History of Syphilis Infection Among a Sample of Transgender Women in Jamaica. ( 29420443 )
2018
19
Rapid Increases in Syphilis in Reproductive-Aged Women in Japan: A Warning for Other Countries? ( 29420440 )
2018
20
Corrigendum: Treponema pallidum (syphilis) antigen TpF1 induces angiogenesis through the activation of the IL-8 pathway. ( 29449640 )
2018
21
Differences in Partner Services Outcomes for Men Who Have Sex With Men Diagnosed With Primary and Secondary Syphilis by HIV Serostatus. ( 29420442 )
2018
22
A rare presentation of congenital syphilis: Pemphigus syphiliticus in a newborn infant with extensive desquamation of the extremities. ( 29314211 )
2018
23
Cross-sectional study of Treponema pallidum PCR in diagnosis of primary and secondary syphilis. ( 29090453 )
2018
24
Congenital syphilis in 2 children in a Bolivian prison. ( 29364335 )
2017
25
Unusual presentation of secondary syphilis: membranoproliferative glomerulonephritis andmuco-cutaneous lesions. ( 28950764 )
2017
26
Unique manifestations and risk factors of Jarisch-Herxheimer reaction during treatment of child congenital syphilis. ( 28942420 )
2017
27
Congenital Syphilis of Bone: A Potential Mimicker of Childhood Histiocytoses. ( 28614210 )
2017
28
Secondary syphilis: An unusual presentation. ( 28442816 )
2017
29
Factors associated with syphilis treatment failure and reinfection: a longitudinal cohort study in Shenzhen, China. ( 28903736 )
2017
30
Congenital syphilis in neonates with nonreactive nontreponemal test results. ( 28682315 )
2017
31
Ocular involvement with secondary syphilis in a non-HIV infected man. ( 28840111 )
2017
32
Prevalence of syphilis and HIV infection during pregnancy in incarcerated women and the incidence of congenital syphilis in births in prison in Brazil. ( 29166489 )
2017
33
Dental Traits of Congenital Syphilis Revisited in Dental Outpatient Department (OPD). ( 28342059 )
2017
34
Educational intervention in Primary Care for the prevention of congenital syphilis. ( 28146181 )
2017
35
Psoriasiform papules, condyloma lata, lung nodules and hepatitis: the enormous variability of secondary syphilis manifestations. ( 28476906 )
2017
36
Brief report: Use of ICD-10 code A51.31 (condyloma latum) for identifying cases of secondary syphilis. ( 28953413 )
2017
37
Primary syphilis in pregnancy mistaken for genital herpes: A preventable cause of congenital syphilis. ( 29103618 )
2017
38
Early Congenital Syphilis: Recognising Symptoms of an Increasingly Prevalent Disease. ( 28821219 )
2017
39
Secondary Syphilis Associated with Membranous Nephropathy and Acute Hepatitis in a Patient with HIV: A Case Report. ( 29236656 )
2017
40
Factors associated with syphilis incidence in the HIV-infected in the era of highly active antiretrovirals. ( 28079818 )
2017
41
Pityriasis rosea in a patient with retrovirus infection and a history of syphilis and positive results of infection with hepatitis A virus, hepatitis B virus and hepatitis C virus. ( 28670260 )
2017
42
Stevens Johnson Syndrome versus Jarisch Herxheimer Reaction in an HIV Positive Patient with Secondary Syphilis. ( 29076438 )
2017
43
Congenital Syphilis: Time for a National Prevention Program. ( 28703732 )
2017
44
Syphilis in Pregnancy and Congenital Syphilis: Reality in a Portuguese Central University Hospital. ( 28609805 )
2017
45
Rare isolated oral manifestations of secondary syphilis in an adolescent. ( 29099372 )
2017
46
Factors associated with four atypical cases of congenital syphilis in England, 2016 to 2017: an ecological analysis. ( 29233254 )
2017
47
Congenital syphilis with bone lesion: case report. ( 29234661 )
2017
48
Neurosyphilis Increases Human Immunodeficiency Virus (HIV)-associated Central Nervous System Inflammation but Does Not Explain Cognitive Impairment in HIV-infected Individuals With Syphilis. ( 28525592 )
2017
49
Screening for asymptomatic neurosyphilis in HIV patients after treatment of early syphilis: an observational study. ( 28196838 )
2017
50
Barriers and facilitators to the implementation of antenatal syphilis screening and treatment for the prevention of congenital syphilis in the Democratic Republic of Congo and Zambia: results of qualitative formative research. ( 28807019 )
2017

Variations for Syphilis

Copy number variations for Syphilis from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 111152 17 35097918 35138441 Copy number ERBB2 Syphilis

Expression for Syphilis

Search GEO for disease gene expression data for Syphilis.

Pathways for Syphilis

GO Terms for Syphilis

Cellular components related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.86 APOH B2M CAT CD209 FAS HLA-C
2 focal adhesion GO:0005925 9.62 B2M CAT MYH9 PPIB
3 external side of plasma membrane GO:0009897 9.26 B2M CD209 CD40LG CD79A
4 MHC class I protein complex GO:0042612 9.16 B2M HLA-C
5 cell surface GO:0009986 9.1 APOH B2M CD209 CD40LG FAS HLA-C

Biological processes related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte cell-cell adhesion GO:0007159 8.96 CD209 CD40LG
2 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 8.62 B2M HLA-C

Molecular functions related to Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein membrane anchor GO:0043495 8.62 MYH9 TPR

Sources for Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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