MCID: SYR002
MIFTS: 45

Syringocystadenoma Papilliferum

Categories: Rare diseases, Skin diseases, Cancer diseases

Aliases & Classifications for Syringocystadenoma Papilliferum

MalaCards integrated aliases for Syringocystadenoma Papilliferum:

Name: Syringocystadenoma Papilliferum 12 72 49 55 14 69
Fistulous Vegetative Verrucous Hydradenoma 49 55
Naevus Syringocystadenomatosus Papilliferus 55
Syringadenoma Papilliferum 55
Papillary Syringadenoma 12
Papillary Hidradenoma 69
Scap 55

Characteristics:

Orphanet epidemiological data:

55
syringocystadenoma papilliferum
Inheritance: Not applicable; Age of onset: Adolescent,Childhood,Infancy,Neonatal;

Classifications:

Orphanet: 55  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:5445
NCIt 46 C4172
SNOMED-CT 64 239121009 8934006
Orphanet 55 ORPHA840
UMLS via Orphanet 70 C0406803
ICD10 via Orphanet 33 D23.9
UMLS 69 C0406803

Summaries for Syringocystadenoma Papilliferum

MalaCards based summary : Syringocystadenoma Papilliferum, also known as fistulous vegetative verrucous hydradenoma, is related to apocrine adenoma and hidradenoma, and has symptoms including subcutaneous nodule, sparse scalp hair and abnormal blistering of the skin. An important gene associated with Syringocystadenoma Papilliferum is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Development EGFR signaling pathway and Cytoskeletal Signaling. Affiliated tissues include skin and lung, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 72 Syringocystadenoma papilliferum (also known as \"syringadenoma papilliferum\") is a benign apocrine... more...

Related Diseases for Syringocystadenoma Papilliferum

Diseases related to Syringocystadenoma Papilliferum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 231)
# Related Disease Score Top Affiliating Genes
1 apocrine adenoma 31.3 KRAS MUC1
2 hidradenoma 30.7 MUC1 VIM
3 adenosquamous carcinoma 30.0 KRAS MUC1
4 cutaneous leiomyosarcoma 29.4 ACTC1 DES GFAP VIM
5 astrocytoma 29.1 GFAP KRAS S100B VIM
6 leiomyosarcoma 28.9 ACTC1 DES S100B VIM
7 syringoma 28.7 DES GFAP MUC1 S100B VIM
8 adenoma 10.6
9 basal cell carcinoma 1 10.5
10 basal cell carcinoma 10.5
11 schimmelpenning-feuerstein-mims syndrome 10.4
12 anaplastic ganglioglioma 10.4 ACTC1 GFAP
13 hyperplastic polyposis syndrome 10.4 BRAF KRAS
14 tumor suppressor gene on chromosome 11 10.4 BRAF KRAS
15 struma ovarii 10.4 BRAF KRAS
16 mature teratoma 10.3 BRAF KRAS
17 pulmonic stenosis 10.3 BRAF KRAS
18 binswanger's disease 10.3 ACTC1 GFAP
19 gliomatosis peritonei 10.3 DES GFAP
20 necrotizing sialometaplasia 10.3 ACTC1 GFAP
21 pleomorphic xanthoastrocytoma 10.3 BRAF GFAP
22 ampulla of vater neoplasm 10.3 KRAS MUC1
23 pulmonary blastoma 10.3 DES KRAS
24 ovarian fibrothecoma 10.3 ACTC1 DES
25 appendix cancer 10.3 KRAS MUC1
26 fibroblastic rheumatism 10.3 ACTC1 DES
27 biliary papillomatosis 10.3 KRAS MUC1
28 colloid carcinoma of the pancreas 10.3 KRAS MUC1
29 pulmonary vein stenosis 10.3 ACTC1 DES
30 cystic nephroma 10.3 ACTC1 DES
31 duodenum cancer 10.2 KRAS MUC1
32 dedifferentiated liposarcoma 10.2 ACTC1 DES
33 biliary tract neoplasm 10.2 KRAS MUC1
34 pseudomyxoma peritonei 10.2 KRAS MUC1
35 lymphangiectasis 10.2 ACTC1 VIM
36 ependymoblastoma 10.2 GFAP VIM
37 astroblastoma 10.2 GFAP VIM
38 glomangiomyoma 10.2 ACTC1 VIM
39 melanotic neuroectodermal tumor 10.2 GFAP VIM
40 chickenpox 10.2 ACTC1 MUC1
41 medulloepithelioma 10.2 GFAP VIM
42 intravascular papillary endothelial hyperplasia 10.2 ACTC1 VIM
43 mucinous adenocarcinoma 10.2 KRAS MUC1
44 medullomyoblastoma 10.2 DES GFAP
45 spindle cell thymoma 10.2 DES MUC1
46 bile duct adenocarcinoma 10.2 KRAS MUC1
47 squamous cell carcinoma 10.2
48 papillary adenoma 10.2
49 hidrocystoma 10.2
50 plasmablastic lymphoma 10.2 DES MUC1

Graphical network of the top 20 diseases related to Syringocystadenoma Papilliferum:



Diseases related to Syringocystadenoma Papilliferum

Symptoms & Phenotypes for Syringocystadenoma Papilliferum

Human phenotypes related to Syringocystadenoma Papilliferum:

55 31
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 subcutaneous nodule 55 31 hallmark (90%) Very frequent (99-80%) HP:0001482
2 sparse scalp hair 55 31 hallmark (90%) Very frequent (99-80%) HP:0002209
3 abnormal blistering of the skin 55 31 frequent (33%) Frequent (79-30%) HP:0008066
4 nevus sebaceous 55 31 occasional (7.5%) Occasional (29-5%) HP:0010815
5 papule 55 31 hallmark (90%) Very frequent (99-80%) HP:0200034

GenomeRNAi Phenotypes related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.36 BRAF KRAS MUC1
2 Decreased viability GR00106-A-0 9.36 KRAS
3 Decreased viability GR00221-A-1 9.36 KRAS
4 Decreased viability GR00221-A-2 9.36 KRAS
5 Decreased viability GR00221-A-4 9.36 BRAF
6 Decreased viability GR00301-A 9.36 BRAF KRAS
7 Decreased viability GR00381-A-1 9.36 BRAF KRAS
8 Decreased cell migration GR00055-A-1 9.26 BRAF KRAS MUC1 VIM

MGI Mouse Phenotypes related to Syringocystadenoma Papilliferum:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 VIM ACTC1 BRAF DES GFAP KRAS
2 homeostasis/metabolism MP:0005376 9.5 VIM ACTC1 BRAF DES GFAP KRAS
3 muscle MP:0005369 9.1 VIM ACTC1 BRAF DES GFAP KRAS

Drugs & Therapeutics for Syringocystadenoma Papilliferum

Search Clinical Trials , NIH Clinical Center for Syringocystadenoma Papilliferum

Genetic Tests for Syringocystadenoma Papilliferum

Anatomical Context for Syringocystadenoma Papilliferum

MalaCards organs/tissues related to Syringocystadenoma Papilliferum:

38
Skin, Lung

Publications for Syringocystadenoma Papilliferum

Articles related to Syringocystadenoma Papilliferum:

(show top 50) (show all 159)
# Title Authors Year
1
Contiguous verrucous proliferations in syringocystadenoma papilliferum: A retrospective analysis with additional evaluation via mutation-specific BRAFV600E immunohistochemistry. ( 29206289 )
2018
2
Dermoscopy of a rare case of linear syringocystadenoma papilliferum with review of the literature. ( 29445572 )
2018
3
Blaschko-linear Syringocystadenoma Papilliferum: A Peculiar Presentation. ( 29204402 )
2017
4
Dermoscopy of syringocystadenoma papilliferum. ( 28695704 )
2017
5
Squamous cell carcinoma arising from syringocystadenoma papilliferum of the eyelid. ( 29217053 )
2017
6
Syringocystadenoma Papilliferum of the External Auditory Canal. ( 28490727 )
2017
7
Syringocystadenoma papilliferum combined with a tubular apocrine adenoma. ( 29166517 )
2017
8
Eyelid syringocystadenoma papilliferum: A novel presentation with major review. ( 29053036 )
2017
9
Syringocystadenoma Papilliferum in Coexistence With Verrucous Carcinoma on the Face. ( 29112527 )
2017
10
Syringocystadenoma Papilliferum of Sweat Gland of Caruncle: A Unique Case Report. ( 28936056 )
2017
11
A Case of Syringocystadenoma Papilliferum with Tubular Papillary Adenoma of the Chest. ( 28502963 )
2017
12
Linear syringocystadenoma papilliferum on the retroauricular area associated with nevus sebaceus. ( 28329571 )
2016
13
Syringocystadenoma papilliferum of the external auditory canal. Case report and literature review. ( 27658577 )
2016
14
Tubulopapillary Cystic Adenoma With Apocrine Differentiation: A Unifying Concept for Syringocystadenoma Papilliferum, Apocrine Gland Cyst, and Tubular Papillary Adenoma. ( 28033156 )
2016
15
Syringocystadenoma papilliferum with multiple lung metastases and long survival. ( 27837643 )
2016
16
Syringocystadenoma Papilliferum of the Scalp Arising from a Nevus Sebaceous. ( 27761094 )
2016
17
Eruptive Syringocystadenoma Papilliferum, Keratoacanthoma, and Verruca Vulgaris in a Keratinocytic Epidermal Nevus on the Leg. ( 26790513 )
2015
18
Multiple pigmented trichoblastomas, sebaceous carcinoma and syringocystadenoma papilliferum arising within a nevus sebaceous. ( 25906325 )
2015
19
Trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma, and tumor of the follicular infundibulum with signet-ring cells, all arising in nevus sebaceus. ( 25761672 )
2015
20
Syringocystadenoma papilliferum arising on naevus sebaceus: A 6-year-old child case described with dermoscopic features. ( 25900640 )
2015
21
Syringocystadenoma papilliferum in an unusual location. ( 26734876 )
2015
22
Somatic BRAF c.1799T>A p.V600E Mosaicism syndrome characterized by a linear syringocystadenoma papilliferum, anaplastic astrocytoma, and ocular abnormalities. ( 26360803 )
2015
23
Activating mutations in the RAS/mitogen-activated protein kinase signaling pathway in sporadic trichoblastoma and syringocystadenoma papilliferum. ( 25532942 )
2015
24
Fifteen year natural history of lower eyelid syringocystadenoma papilliferum in a young girl. ( 26097022 )
2015
25
Tricholemmoma, sebaceoma, syringocystadenoma papilliferum, basal cell carcinoma, trichilemmal cyst arising within a nevus sebaceous. ( 26224239 )
2015
26
Basal Cell Carcinoma and Syringocystadenoma Papilliferum Arising in Nevus Sebaceous on Face-A Rare Entity. ( 26677302 )
2015
27
A case of syringocystadenoma papilliferum of eyelid with literature review. ( 26265653 )
2015
28
Syringocystadenoma papilliferum of the male nipple. ( 26269194 )
2015
29
Somatic V600E BRAF Mutation in Linear and Sporadic Syringocystadenoma Papilliferum. ( 25950823 )
2015
30
Cytological diagnosis of syringocystadenoma papilliferum a rare adnexal tumor. ( 26229253 )
2015
31
Syringocystadenoma papilliferum: an unusual presentation. ( 24995228 )
2014
32
Syringocystadenoma papilliferum of the upper lip. ( 25364565 )
2014
33
Syringocystadenoma papilliferum developing over hyperkeratosis of the nipple in a pregnant woman. ( 24629369 )
2014
34
Linear syringocystadenoma papilliferum on female breast: a rare appendageal tumour on an uncommon location. ( 25756479 )
2014
35
Syringocystadenoma papilliferum of the bony external auditory canal: a rare tumor in a rare location. ( 23762705 )
2013
36
Agminated syringocystadenoma papilliferum: a new clinical presentation of a rare benign adnexal neoplasm. ( 24021448 )
2013
37
A case of syringocystadenoma papilliferum on lower leg: a rare location. ( 24082194 )
2013
38
Syringocystadenoma papilliferum arising on the scrotum. ( 22612442 )
2013
39
Syringocystadenoma papilliferum of the scalp in an adult male - a case report. ( 23730665 )
2013
40
Linear syringocystadenoma papilliferum: a case report with review of literature. ( 24082219 )
2013
41
Syringocystadenoma papilliferum on the dorsum of the foot. ( 23621843 )
2013
42
Follicular hybrid cyst with isthmic-catagen, pilomatrical, and syringocystadenoma papilliferum components. ( 22699865 )
2013
43
Syringocystadenoma papilliferum in the right lower abdomen: a case report and review of literature. ( 23569386 )
2013
44
Carcino-sarcoma in a case of syringocystadenoma papilliferum: a rare entity. ( 24765470 )
2012
45
Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands: report of a case and review of the literature. ( 22262361 )
2012
46
Giant linear syringocystadenoma papilliferum of the back. ( 22199089 )
2012
47
Adult-onset linear syringocystadenoma papilliferum over the inguinal fold: a case report with emphasis on mast cell staining pattern. ( 23217957 )
2012
48
Basal cell carcinoma, syringocystadenoma papilliferum, trichilemmoma, and sebaceoma arising within a nevus sebaceus associated with pigmented nevi. ( 22093024 )
2011
49
Dermoscopic aspects of syringocystadenoma papilliferum associated with nevus sebaceus. ( 22281917 )
2011
50
Linear syringocystadenoma papilliferum: an unusual location. ( 21276059 )
2011

Variations for Syringocystadenoma Papilliferum

Expression for Syringocystadenoma Papilliferum

Search GEO for disease gene expression data for Syringocystadenoma Papilliferum.

Pathways for Syringocystadenoma Papilliferum

GO Terms for Syringocystadenoma Papilliferum

Cellular components related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.56 ACTC1 BRAF DES GFAP KRAS MUC1
2 intermediate filament GO:0005882 9.33 DES GFAP VIM
3 cell body GO:0044297 8.8 ACTC1 BRAF GFAP

Biological processes related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.67 ACTC1 BRAF KRAS VIM
2 visual learning GO:0008542 9.43 BRAF KRAS
3 astrocyte development GO:0014002 9.4 GFAP VIM
4 long-term synaptic potentiation GO:0060291 9.33 BRAF GFAP S100B
5 Bergmann glial cell differentiation GO:0060020 9.32 GFAP VIM
6 intermediate filament-based process GO:0045103 9.26 GFAP VIM
7 muscle filament sliding GO:0030049 9.13 ACTC1 DES VIM
8 intermediate filament organization GO:0045109 8.8 DES GFAP VIM

Molecular functions related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 BRAF DES GFAP S100B VIM
2 structural constituent of cytoskeleton GO:0005200 8.8 DES GFAP VIM

Sources for Syringocystadenoma Papilliferum

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70 UMLS via Orphanet
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