MCID: SYR002
MIFTS: 47

Syringocystadenoma Papilliferum malady

Rare diseases, Skin diseases, Cancer diseases categories

Summaries for Syringocystadenoma Papilliferum

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66Wikipedia, 34MalaCards
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Wikipedia:66 Syringocystadenoma papilliferum (also known as \"Syringadenoma papilliferum\") is an apocrine tumor. more...

MalaCards: Syringocystadenoma Papilliferum, also known as fistulous vegetative verrucous hydradenoma, is related to basal cell carcinoma and hidradenoma, and has symptoms including subcutaneous nodules/lipomas/tumefaction/swelling, follicular/erythematous/edematous papules/milium and vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment. An important gene associated with Syringocystadenoma Papilliferum is PTCH1 (patched 1), and among its related pathways is Striated Muscle Contraction. The compounds 2-methoxyethanol and actomyosin have been mentioned in the context of this disorder. Affiliated tissues include skin and breast.

Aliases & Classifications for Syringocystadenoma Papilliferum

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 50Orphanet, 63UMLS, 59SNOMED-CT, 41NCIt, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Skin diseases


Characteristics (Orphanet epidemiological data):

50
syringocystadenoma papilliferum:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

syringocystadenoma papilliferum 9 44 11 50 63
fistulous vegetative verrucous hydradenoma 44 50
papillary syringadenoma 9


External Ids:

Disease Ontology9 DOID:5445
NCIt41 C4172
ICD10 via Orphanet27 D23.9
SNOMED-CT59 239121009, 8934006
SNOMED-CT via Orphanet60 239121009
UMLS via Orphanet64 C0406803

Related Diseases for Syringocystadenoma Papilliferum

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18GeneCards, 19GeneDecks
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Diseases related to Syringocystadenoma Papilliferum via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1basal cell carcinoma31.0ACTC1, KRT15, PTCH1, PIP
2hidradenoma31.0PIP, CLEC2A, MUC1
3syringoma30.8MUC1, S100B
4leiomyosarcoma30.3VIM, MUC1, ACTC1, S100B
5melanoma30.2PTCH1, ACTC1, PCNA, S100B, VIM
6adenoma10.8
7apocrine adenoma10.8
8hidrocystoma10.4
9cystadenoma10.3
10sebaceous adenoma10.3
11focal dermal hypoplasia10.3
12cutaneous leiomyosarcoma10.3
13adenoiditis10.3
14sweat gland carcinoma10.3
15verrucous carcinoma10.3
16adenosquamous carcinoma10.3
17niemann-pick disease10.3
18acanthoma10.1CLEC2A
19histiocytosis10.1S100B
20ganglioglioma10.1S100B
21hemangioma10.1ACTC1
22cystadenocarcinoma10.1MUC1
23spiradenoma10.1KRT15, CLEC2A
24embryonal rhabdomyosarcoma10.1PTCH1, ACTC1
25adenomatoid tumor10.1VIM
26alopecia10.1KRT15, CLEC2A
27papilloma10.1ACTC1, PCNA
28cutaneous fibrous histiocytoma10.1ACTC1, S100B
29cutaneous paget's disease10.1PIP, MUC1
30adenoameloblastoma10.0PCNA, PTCH1
31breast fibroadenoma10.0PCNA, KRT15
32tubular adenocarcinoma10.0MUC1, ACTC1
33fibrous meningioma10.0MUC1, S100B
34anaplastic ependymoma10.0S100B, MUC1
35choroid plexus papilloma10.0S100B, MUC1
36glomus tumor10.0VIM, ACTC1
37microphthalmia10.0ACTC1, S100B
38bladder carcinoma10.0PTCH1, ACTC1
39epithelioid leiomyosarcoma10.0ACTC1, VIM
40hemangioblastoma10.0MUC1, S100B
41pseudosarcomatous fibromatosis10.0VIM, ACTC1
42endometrial stromal sarcoma10.0VIM, ACTC1
43neuroendocrine carcinoma10.0MUC1, S100B
44angiomyolipoma10.0ACTC1, VIM
45fibromatosis10.0ACTC1, VIM
46medulloblastoma10.0S100B, PTCH1, ACTC1
47granular cell tumor10.0VIM, S100B
48clear cell ependymoma10.0VIM, MUC1
49xeroderma pigmentosum10.0PCNA, PTCH1
50mesenchymal chondrosarcoma10.0VIM, MUC1

Graphical network of the top 20 diseases related to Syringocystadenoma Papilliferum:



Diseases related to syringocystadenoma papilliferum

Symptoms for Syringocystadenoma Papilliferum

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50Orphanet
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Symptoms:

50
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • follicular/erythematous/edematous papules/milium
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • capillary hemangioma/nevus/naevus flammeus/port-wine stain
  • skin/cutaneous neoplasm/tumor/carcinoma/cancer (excluding melanoma)

Drugs & Therapeutics for Syringocystadenoma Papilliferum

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Syringocystadenoma Papilliferum

Drug clinical trials:

Search ClinicalTrials for Syringocystadenoma Papilliferum

Search NIH Clinical Center for Syringocystadenoma Papilliferum

Search CenterWatch for Syringocystadenoma Papilliferum

Genetic Tests for Syringocystadenoma Papilliferum

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Anatomical Context for Syringocystadenoma Papilliferum

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34MalaCards
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MalaCards organs/tissues related to Syringocystadenoma Papilliferum:

34
Skin, Breast

Animal Models for Syringocystadenoma Papilliferum or affiliated genes

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Publications for Syringocystadenoma Papilliferum

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53PubMed
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Articles related to Syringocystadenoma Papilliferum:

(show top 50)    (show all 122)
idTitleAuthorsYear
1
Syringocystadenoma papilliferum arising on the scrotum. (22612442)
2013
2
Syringocystadenoma papilliferum of the bony external auditory canal: a rare tumor in a rare location. (23762705)
2013
3
Agminated syringocystadenoma papilliferum: a new clinical presentation of a rare benign adnexal neoplasm. (24021448)
2013
4
A case of syringocystadenoma papilliferum on lower leg: a rare location. (24082194)
2013
5
Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands: report of a case and review of the literature. (22262361)
2012
6
Adult-onset linear syringocystadenoma papilliferum over the inguinal fold: a case report with emphasis on mast cell staining pattern. (23217957)
2012
7
Basal cell carcinoma, syringocystadenoma papilliferum, trichilemmoma, and sebaceoma arising within a nevus sebaceus associated with pigmented nevi. (22093024)
2011
8
Syringocystadenoma papilliferum of the back combined with a tubular apocrine adenoma. (22148038)
2011
9
Linear syringocystadenoma papilliferum: an uncommon event with a favorable prognosis. (21906485)
2011
10
Lipomatous apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. (21854651)
2011
11
Syringocystadenoma papilliferum on the male nipple. (21914158)
2011
12
Syringocystadenoma papilliferum: Unusual location. (21696687)
2011
13
A case of zonal syringocystadenoma papilliferum of the axilla mimicking verruca vulgaris. (20098083)
2010
14
Syringocystadenoma papilliferum: an unusual presentation. (20199464)
2009
15
Syringocystadenoma papilliferum-like lesion of the vulva. (18752136)
2008
16
Congenital syringocystadenoma papilliferum. (18304179)
2008
17
Ductal carcinoma arising from syringocystadenoma papilliferum in the external auditory canal. (17159662)
2007
18
Trichoblastoma and syringocystadenoma papilliferum arising in naevus sebaceous in a 4-year-old boy. (17342802)
2007
19
Syringocystadenoma papilliferum associated with apocrine poroma. (16674787)
2006
20
Basal cell carcinoma and syringocystadenoma papilliferum arising in nevus sebaceus. (16404295)
2006
21
Syringocystadenoma papilliferum: report of 8 cases. (17036946)
2006
22
Syringocystadenoma papilliferum of the eyelid in a young girl. (16418676)
2006
23
Syringocystadenoma papilliferum: a rare breast tumor in a young boy. (16953682)
2006
24
A 64-year-old woman with vulvar papule. Vulvar syringocystadenoma papilliferum. (15859658)
2005
25
Tubular apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. (16354370)
2005
26
Tubular apocrine adenoma in association with syringocystadenoma papilliferum. (12639465)
2003
27
Syringocystadenoma papilliferum arising on the scrotum. (12822557)
2003
28
Syringocystadenoma papilliferum mimicking basal cell carcinoma on the lower eyelid: a case report. (12661924)
2002
29
Trichilemmoma and syringocystadenoma papilliferum arising in naevus sebaceous. (12009106)
2002
30
Linear warty papules on the neck of a young woman: syringocystadenoma papilliferum (SP) in a sebaceous nevus (SN). (12164752)
2002
31
Syringocystadenoma papilliferum: a study of potential tumor suppressor genes. (11285401)
2001
32
Mixed syringocystadenoma papilliferum and papillary eccrine adenoma occurring in a scrotal condyloma. (10774942)
2000
33
Syringocystadenoma papilliferum presenting as a cutaneous horn. (10848760)
2000
34
Syringocystadenoma papilliferum mimicking breast carcinoma. (10698227)
2000
35
Multiple linear syringocystadenoma papilliferum. (10188162)
1999
36
Syringocystadenoma papilliferum without an antecedent naevus sebaceous. (10384930)
1999
37
A case of ductal sweat gland carcinoma connected to syringocystadenoma papilliferum arising in nevus sebaceus. (7699123)
1994
38
Condyloma acuminatum associated with syringocystadenoma papilliferum. (7864300)
1994
39
Fine needle aspiration cytology of chondroid syringoma and syringocystadenoma papilliferum. A report of two cases. (8392255)
1993
40
Syringocystadenoma papilliferum: report of an unusual case. (1661713)
1991
41
A case of tubular apocrine adenoma with syringocystadenoma papilliferum. (2551940)
1989
42
Nevus sebaceus, syringocystadenoma papilliferum, and basal cell epithelioma. (2995466)
1985
43
Syringocystadenoma papilliferum. A plasmacytotropic tumor. (2996375)
1985
44
Congenital papillated apocrine cystadenoma: a mixed form of hidrocystoma, hidradenoma papilliferum, and syringocystadenoma papilliferum. (6090513)
1984
45
Pathology quiz case 2: syringocystadenoma papilliferum. (6279032)
1982
46
Syringocystadenoma papilliferum of the eyelid. (6275322)
1981
47
Syringocystadenoma papilliferum in an unusual location. Report of a case. (182084)
1976
48
Syringocystadenoma papilliferum: light and electron microscopic studies. (78616)
1976
49
A mixed tumor occurring as a syringocystadenoma papilliferum with a nevus sebaceus; report of a case. (13486945)
1958
50
Syringocystadenoma papilliferum, nevus sebaceus and basal-cell epithelioma (with features of epithelioma adenoides cysticum and syringoma); their concurrent presence in a single tumor; report of a case. (14901605)
1951

Variations for Syringocystadenoma Papilliferum

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Expression for genes affiliated with Syringocystadenoma Papilliferum

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Syringocystadenoma Papilliferum

Search GEO for disease gene expression data for Syringocystadenoma Papilliferum.

Pathways for genes affiliated with Syringocystadenoma Papilliferum

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51PathCards, 39NCBI BioSystems Database, 56Reactome
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Pathways related to Syringocystadenoma Papilliferum according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7ACTC1, VIM

Compounds for genes affiliated with Syringocystadenoma Papilliferum

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Sources:
46Novoseek, 12DrugBank, 3BitterDB, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 25HMDB
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Compounds related to Syringocystadenoma Papilliferum according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
12-methoxyethanol4610.0ACTC1, VIM
2actomyosin469.9VIM, ACTC1
3temozolomide46 1210.8PCNA, VIM
43-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide469.8PCNA, S100B
5orcein469.7VIM, ACTC1, S100B
6roscovitine469.7VIM, PCNA
74-hydroxytamoxifen469.6S100B, VIM
8matrigel469.6VIM, MUC1, ACTC1
9chloramphenicol46 3 52 1212.6VIM, MUC1, S100B
10calcipotriol46 62 30 1212.5KRT15, VIM
11procollagen469.5VIM, ACTC1, PCNA
12bromodeoxyuridine469.5VIM, PCNA, S100B
13cytarabine46 52 1211.5PCNA, MUC1, VIM
14forskolin46 52 1211.4S100B, MUC1, VIM
15methotrexate52 46 1211.4VIM, MUC1, PCNA
16etoposide46 52 62 1212.4S100B, PCNA, VIM
17paclitaxel46 52 1211.4S100B, PCNA, VIM
18cyclosporin a46 30 6211.4S100B, PCNA, ACTC1
19butyrate469.4VIM, MUC1, PCNA
20iron46 2510.4S100B, ACTC1, VIM
21hydroxyapatite469.3S100B, VIM
22dihydrotestosterone46 30 25 1212.3MUC1, VIM, PIP
23s 100469.3S100B, ACTC1, MUC1, VIM
24glycogen46 2510.3S100B, ACTC1, MUC1, VIM
25glutamine469.2VIM, PCNA, S100B
26biotin46 25 1211.2VIM, MUC1, ACTC1, PCNA
27eosin469.1VIM, MUC1, PCNA, S100B
28lactate469.1VIM, PCNA, S100B
29thymidine46 2510.1S100B, PCNA, MUC1
30cysteine469.0S100B, PCNA, MUC1, VIM
31tamoxifen46 52 30 1211.9PIP, VIM, MUC1, PCNA
32estradiol46 25 1210.8PCNA, MUC1, VIM, PIP
33reticulin468.8VIM, MUC1, ACTC1, PCNA, S100B
34hematoxylin468.8VIM, MUC1, ACTC1, PCNA, S100B
35formaldehyde46 259.8S100B, PCNA, ACTC1, MUC1, VIM
36creatinine468.8VIM, MUC1, ACTC1, PCNA, S100B
37dexamethasone46 52 30 1211.8S100B, PCNA, ACTC1, MUC1, VIM
38vegf468.8VIM, MUC1, ACTC1, PCNA, S100B
39mucicarmine468.7PIP, VIM, MUC1, ACTC1, S100B
40tyrosine468.5KRT15, S100B, ACTC1, MUC1, PTCH1
41b 723468.2S100B, PCNA, ACTC1, MUC1, VIM, PIP
42progesterone46 30 62 25 1212.2PIP, VIM, MUC1, ACTC1, PCNA, S100B
43testosterone46 62 25 1211.2PIP, VIM, MUC1, ACTC1, PCNA, S100B
44estrogen468.2PIP, VIM, MUC1, ACTC1, PCNA, S100B
45retinoic acid46 258.9VIM, MUC1, ACTC1, PCNA, S100B, KRT15
46paraffin467.9PIP, PTCH1, VIM, MUC1, ACTC1, PCNA

GO Terms for genes affiliated with Syringocystadenoma Papilliferum

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17Gene Ontology
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Cellular components related to Syringocystadenoma Papilliferum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700627.3KRT15, PCNA, ACTC1, MUC1, VIM, PIP

Biological processes related to Syringocystadenoma Papilliferum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.7ACTC1, VIM

Molecular functions related to Syringocystadenoma Papilliferum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:0019489.4VIM, PIP
2scaffold protein bindingGO:0971109.1KRT15, VIM
3protein bindingGO:0055156.7PTCH1, CLEC2A, VIM, MUC1, PCNA, S100B

Products for genes affiliated with Syringocystadenoma Papilliferum

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Sources for Syringocystadenoma Papilliferum

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet