MCID: SYR002
MIFTS: 42

Syringocystadenoma Papilliferum malady

Rare diseases, Skin diseases, Cancer diseases categories

Aliases & Classifications for Syringocystadenoma Papilliferum

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 65UMLS, 59SNOMED-CT, 42NCIt, 28ICD10 via Orphanet, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Syringocystadenoma Papilliferum:

Name: Syringocystadenoma Papilliferum 10 45 12 51 65
Fistulous Vegetative Verrucous Hydradenoma 45 51
Naevus Syringocystadenomatosus Papilliferus 51
 
Syringadenoma Papilliferum 51
Papillary Syringadenoma 10
Scap 51


Classifications:



Characteristics (Orphanet epidemiological data):

51
syringocystadenoma papilliferum:
Inheritance: Not applicable; Age of onset: Childhood


External Ids:

Disease Ontology10 DOID:5445
NCIt42 C4172
Orphanet51 840
SNOMED-CT59 239121009, 8934006
ICD10 via Orphanet28 D23.9
UMLS via Orphanet66 C0406803

Summaries for Syringocystadenoma Papilliferum

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Wikipedia:68 Syringocystadenoma papilliferum (also known as \"Syringadenoma papilliferum\") is an apocrine tumor. more...

MalaCards based summary: Syringocystadenoma Papilliferum, also known as fistulous vegetative verrucous hydradenoma, is related to adenoma and apocrine adenoma, and has symptoms including abnormal hair quantity, abnormal blistering of the skin and neoplasm of the skin. An important gene associated with Syringocystadenoma Papilliferum is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways are Nuclear signaling by ERBB4 and Aurora B signaling. Affiliated tissues include skin and breast, and related mouse phenotypes are normal and muscle.

Related Diseases for Syringocystadenoma Papilliferum

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Diseases related to Syringocystadenoma Papilliferum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 234)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.0ACTC1, MUC1, VIM
2apocrine adenoma10.8
3basal cell carcinoma10.7
4hidradenoma10.7
5syringoma10.6
6hidrocystoma10.5
7pick disease10.3
8focal dermal hypoplasia10.3
9niemann-pick disease10.3
10verrucous carcinoma10.3
11sebaceous adenoma10.3
12cystadenoma10.3
13sweat gland carcinoma10.3
14adenoiditis10.3
15adenosquamous carcinoma10.3
16astrocytoma10.3
17melanoma10.3
18sarcoma10.3
19urethritis10.2GFAP, S100B
20familial hemiplegic migraine10.2GFAP, S100B
21headache10.2GFAP, S100B
22mixed epithelial tumor of ovary10.2GFAP, KRAS
23pinheiro freire-maia miranda syndrome10.2GFAP, S100B
24global disaccharide intolerance10.2DES, GFAP
25anaplastic oligoastrocytoma10.2ACTC1, GFAP
26rete ovarii cystadenofibroma10.2GFAP, S100B
27aflatoxins-related hepatocellular carcinoma10.2GFAP, S100B
28ulcer of lower limbs10.2GFAP, S100B
29pneumonia10.2
30tricuspid valve prolapse10.2GFAP, S100B
31neonatal glycine encephalopathy10.2ACTC1, S100B
32malignant hypertension10.2ACTC1, S100B
33signet ring basal cell carcinoma10.2ACTC1, S100B
34birdshot chorioretinopathy10.2ACTC1, GFAP
35pulmonary embolism10.2DES, KRAS
362p21 microdeletion syndrome10.2DES, S100B
37atrophoderma vermiculata10.2DES, S100B
38microscopic colitis10.2ACTC1, S100B
39mikulicz disease10.1ACTC1, GFAP
40adult medulloblastoma10.1DES, GFAP
41lung leiomyosarcoma10.1ACTC1, GFAP
42spigelian hernia-cryptorchidism syndrome10.1ACTC1, DES
43progressive sensorineural hearing loss - hypertrophic cardiomyopathy10.1ACTC1, GFAP
44microglandular adenosis of breast10.1GFAP, S100B
45localized lipodystrophy10.1MUC1, S100B
46complex regional pain syndrome type 110.1MUC1, S100B
47microcystic meningioma10.1KRAS, MUC1
48extraneural perineurioma10.1MUC1, S100B
49mixed epithelial stromal tumour10.1GFAP, S100B
50amyloidosis10.1KRAS, MUC1

Graphical network of the top 20 diseases related to Syringocystadenoma Papilliferum:



Diseases related to syringocystadenoma papilliferum

Symptoms for Syringocystadenoma Papilliferum

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Symptoms:

 51
  • follicular/erythematous/edematous papules/milium
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • capillary hemangioma/nevus/naevus flammeus/port-wine stain
  • skin/cutaneous neoplasm/tumor/carcinoma/cancer (excluding melanoma)

HPO human phenotypes related to Syringocystadenoma Papilliferum:

id Description Frequency HPO Source Accession
1 abnormal hair quantity hallmark (90%) HP:0011362
2 abnormal blistering of the skin typical (50%) HP:0008066
3 neoplasm of the skin occasional (7.5%) HP:0008069

Drugs & Therapeutics for Syringocystadenoma Papilliferum

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Syringocystadenoma Papilliferum

Genetic Tests for Syringocystadenoma Papilliferum

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Anatomical Context for Syringocystadenoma Papilliferum

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MalaCards organs/tissues related to Syringocystadenoma Papilliferum:

33
Skin, Breast

Animal Models for Syringocystadenoma Papilliferum or affiliated genes

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MGI Mouse Phenotypes related to Syringocystadenoma Papilliferum:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.3ACTC1, GFAP, KRAS, MUC1, S100B
2MP:00053697.8ACTC1, DES, GFAP, KRAS, VIM
3MP:00053857.7ACTC1, DES, GFAP, KRAS, VIM
4MP:00053767.2ACTC1, DES, GFAP, KRAS, MUC1, VIM

Publications for Syringocystadenoma Papilliferum

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Articles related to Syringocystadenoma Papilliferum:

(show top 50)    (show all 139)
idTitleAuthorsYear
1
Cytological diagnosis of syringocystadenoma papilliferum a rare adnexal tumor. (26229253)
2015
2
Fifteen year natural history of lower eyelid syringocystadenoma papilliferum in a young girl. (26097022)
2015
3
Activating mutations in the RAS/mitogen-activated protein kinase signaling pathway in sporadic trichoblastoma and syringocystadenoma papilliferum. (25532942)
2015
4
Linear syringocystadenoma papilliferum on female breast: a rare appendageal tumour on an uncommon location. (25756479)
2014
5
Syringocystadenoma papilliferum developing over hyperkeratosis of the nipple in a pregnant woman. (24629369)
2014
6
Syringocystadenoma papilliferum: an unusual presentation. (24995228)
2014
7
Syringocystadenoma papilliferum arising on the scrotum. (22612442)
2013
8
Syringocystadenoma papilliferum of the bony external auditory canal: a rare tumor in a rare location. (23762705)
2013
9
Agminated syringocystadenoma papilliferum: a new clinical presentation of a rare benign adnexal neoplasm. (24021448)
2013
10
Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands: report of a case and review of the literature. (22262361)
2012
11
Adult-onset linear syringocystadenoma papilliferum over the inguinal fold: a case report with emphasis on mast cell staining pattern. (23217957)
2012
12
Basal cell carcinoma, syringocystadenoma papilliferum, trichilemmoma, and sebaceoma arising within a nevus sebaceus associated with pigmented nevi. (22093024)
2011
13
Syringocystadenoma papilliferum of the back combined with a tubular apocrine adenoma. (22148038)
2011
14
Linear syringocystadenoma papilliferum: an uncommon event with a favorable prognosis. (21906485)
2011
15
Lipomatous apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. (21854651)
2011
16
Syringocystadenoma papilliferum on the male nipple. (21914158)
2011
17
A case of zonal syringocystadenoma papilliferum of the axilla mimicking verruca vulgaris. (20098083)
2010
18
Syringocystadenoma papilliferum: an unusual presentation. (20199464)
2009
19
Syringocystadenoma papilliferum-like lesion of the vulva. (18752136)
2008
20
Ductal carcinoma arising from syringocystadenoma papilliferum in the external auditory canal. (17159662)
2007
21
Linear syringocystadenoma papilliferum of the scalp. (17243981)
2007
22
Trichoblastoma and syringocystadenoma papilliferum arising in naevus sebaceous in a 4-year-old boy. (17342802)
2007
23
Syringocystadenoma papilliferum associated with apocrine poroma. (16674787)
2006
24
Basal cell carcinoma and syringocystadenoma papilliferum arising in nevus sebaceus. (16404295)
2006
25
Syringocystadenoma papilliferum: report of 8 cases. (17036946)
2006
26
Syringocystadenoma papilliferum of the eyelid in a young girl. (16418676)
2006
27
A 64-year-old woman with vulvar papule. Vulvar syringocystadenoma papilliferum. (15859658)
2005
28
Tubular apocrine adenoma in association with syringocystadenoma papilliferum. (12639465)
2003
29
Syringocystadenoma papilliferum arising on the scrotum. (12822557)
2003
30
Syringocystadenoma papilliferum mimicking basal cell carcinoma on the lower eyelid: a case report. (12661924)
2002
31
Trichilemmoma and syringocystadenoma papilliferum arising in naevus sebaceous. (12009106)
2002
32
Linear warty papules on the neck of a young woman: syringocystadenoma papilliferum (SP) in a sebaceous nevus (SN). (12164752)
2002
33
Syringocystadenoma papilliferum: a study of potential tumor suppressor genes. (11285401)
2001
34
Mixed syringocystadenoma papilliferum and papillary eccrine adenoma occurring in a scrotal condyloma. (10774942)
2000
35
Syringocystadenoma papilliferum presenting as a cutaneous horn. (10848760)
2000
36
Syringocystadenoma papilliferum mimicking breast carcinoma. (10698227)
2000
37
Multiple linear syringocystadenoma papilliferum. (10188162)
1999
38
A case of ductal sweat gland carcinoma connected to syringocystadenoma papilliferum arising in nevus sebaceus. (7699123)
1994
39
Condyloma acuminatum associated with syringocystadenoma papilliferum. (7864300)
1994
40
Fine needle aspiration cytology of chondroid syringoma and syringocystadenoma papilliferum. A report of two cases. (8392255)
1993
41
Syringocystadenoma papilliferum: report of an unusual case. (1661713)
1991
42
A case of tubular apocrine adenoma with syringocystadenoma papilliferum. (2551940)
1989
43
Nevus sebaceus, syringocystadenoma papilliferum, and basal cell epithelioma. (2995466)
1985
44
Syringocystadenoma papilliferum. A plasmacytotropic tumor. (2996375)
1985
45
Pathology quiz case 2: syringocystadenoma papilliferum. (6279032)
1982
46
Syringocystadenoma papilliferum of the eyelid. (6275322)
1981
47
Syringocystadenoma papilliferum in an unusual location. Report of a case. (182084)
1976
48
Syringocystadenoma papilliferum: light and electron microscopic studies. (78616)
1976
49
A mixed tumor occurring as a syringocystadenoma papilliferum with a nevus sebaceus; report of a case. (13486945)
1958
50
Syringocystadenoma papilliferum, nevus sebaceus and basal-cell epithelioma (with features of epithelioma adenoides cysticum and syringoma); their concurrent presence in a single tumor; report of a case. (14901605)
1951

Variations for Syringocystadenoma Papilliferum

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Expression for genes affiliated with Syringocystadenoma Papilliferum

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Search GEO for disease gene expression data for Syringocystadenoma Papilliferum.

Pathways for genes affiliated with Syringocystadenoma Papilliferum

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Pathways related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6GFAP, S100B
2
Show member pathways
9.1DES, VIM
3
Show member pathways
8.8DES, GFAP, VIM
48.6ACTC1, DES, VIM
5
Show member pathways
8.6ACTC1, DES, VIM

GO Terms for genes affiliated with Syringocystadenoma Papilliferum

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Cellular components related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.4DES, GFAP, VIM
2focal adhesionGO:00059259.2ACTC1, KRAS, VIM
3cytoplasmGO:00057376.7ACTC1, DES, GFAP, KRAS, MUC1, S100B

Biological processes related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1long-term synaptic potentiationGO:00602919.7GFAP, S100B
2intermediate filament-based processGO:00451039.7GFAP, VIM
3intermediate filament organizationGO:00451099.7GFAP, VIM
4Bergmann glial cell differentiationGO:00600209.7GFAP, VIM
5negative regulation of neuron projection developmentGO:00109779.6GFAP, VIM
6astrocyte developmentGO:00140029.6GFAP, VIM
7muscle filament slidingGO:00300498.6ACTC1, DES, VIM
8positive regulation of gene expressionGO:00106288.4ACTC1, KRAS, VIM

Molecular functions related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052008.8DES, GFAP, VIM
2structural molecule activityGO:00051988.5DES, GFAP, VIM

Sources for Syringocystadenoma Papilliferum

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet