MCID: SYR002
MIFTS: 43

Syringocystadenoma Papilliferum malady

Categories: Rare diseases, Skin diseases, Cancer diseases

Aliases & Classifications for Syringocystadenoma Papilliferum

About this section
Sources:
65UMLS, 10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Syringocystadenoma Papilliferum:

Name: Syringocystadenoma Papilliferum 10 45 12 51 65
Fistulous Vegetative Verrucous Hydradenoma 45 51
Naevus Syringocystadenomatosus Papilliferus 51
Syringadenoma Papilliferum 51
 
Papillary Syringadenoma 10
Papillary Hidradenoma 65
Scap 51

Characteristics:

Orphanet epidemiological data:

51
syringocystadenoma papilliferum:
Inheritance: Not applicable; Age of onset: Childhood

Classifications:



External Ids:

Disease Ontology10 DOID:5445
NCIt42 C4172
Orphanet51 840
SNOMED-CT59 239121009, 8934006
ICD10 via Orphanet28 D23.9
UMLS via Orphanet66 C0406803
UMLS65 C0406803

Summaries for Syringocystadenoma Papilliferum

About this section
Wikipedia:68 Syringocystadenoma papilliferum (also known as \"Syringadenoma papilliferum\") is an apocrine tumor. more...

MalaCards based summary: Syringocystadenoma Papilliferum, also known as fistulous vegetative verrucous hydradenoma, is related to apocrine adenoma and adenoma, and has symptoms including abnormal hair quantity, abnormal blistering of the skin and neoplasm of the skin. An important gene associated with Syringocystadenoma Papilliferum is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways are Negative regulation of MAPK pathway and MAPK Signaling: Oxidative Stress Pathway. Affiliated tissues include skin, prostate and t cells, and related mouse phenotypes are renal/urinary system and limbs/digits/tail.

Related Diseases for Syringocystadenoma Papilliferum

About this section

Diseases related to Syringocystadenoma Papilliferum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1apocrine adenoma31.1AZGP1, KRT15
2adenoma10.6
3basal cell carcinoma10.5
4hidradenoma10.4
5cataract-intellectual disability-hypogonadism syndrome10.4BRAF, KRAS
6ovarian germ cell teratoma10.4BRAF, KRAS
7in situ pulmonary adenocarcinoma10.3BRAF, KRAS
8punctate acrokeratoderma freckle like pigmentation10.3BRAF, KRAS
9hereditary congenital ptosis10.3BRAF, KRAS
10syringoma10.3
11hidrocystoma10.2
12noonan syndrome 710.1BRAF, KRAS
13connective tissue benign neoplasm10.1KRAS, KRT15
14malignant giant cell tumor of soft parts10.1KRAS, KRT5
15histoplasmosis10.1KRT15, KRT5
16vulvar clear cell hidradenocarcinoma10.1KRT15, KRT5
17pyometritis10.1BRAF, KRAS
18pleomorphic xanthoastrocytoma10.1BRAF, KRAS
19pick disease10.1
20focal dermal hypoplasia10.1
21niemann-pick disease10.1
22adenoiditis10.1
23sarcoma10.1
24melanoma10.1
25leiomyosarcoma10.1
26cystadenoma10.1
27sebaceous adenoma10.1
28astrocytoma10.1
29keratoacanthoma10.1
30verrucous carcinoma10.1
31adenosquamous carcinoma10.1
32cutaneous leiomyosarcoma10.1
33neuroblastoma10.0
34gorham's disease10.0KRAS, KRT5
35familial abdominal aortic aneurysm10.0BRAF, KRAS
36vulvar sarcoma10.0KRT15, KRT5
37myocardial infarction9.8
38prostate cancer9.8
39coronary artery disease9.8
40obesity9.8
41hypertriglyceridemia9.8
42atherosclerosis9.8
43liver disease9.8
44artery disease9.8
45prostatitis9.8
46fatty liver disease9.8
47sudden cardiac death9.8
48clove syndrome, somatic9.7KRT5, SALL1
49cerebellar disease9.6KRT5, SALL1
50endocardium cancer9.6KRT15, KRT5, PORCN

Graphical network of the top 20 diseases related to Syringocystadenoma Papilliferum:



Diseases related to syringocystadenoma papilliferum

Symptoms for Syringocystadenoma Papilliferum

About this section

Symptoms:

 51
  • follicular/erythematous/edematous papules/milium
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • capillary hemangioma/nevus/naevus flammeus/port-wine stain
  • skin/cutaneous neoplasm/tumor/carcinoma/cancer (excluding melanoma)

HPO human phenotypes related to Syringocystadenoma Papilliferum:

id Description Frequency HPO Source Accession
1 abnormal hair quantity hallmark (90%) HP:0011362
2 abnormal blistering of the skin typical (50%) HP:0008066
3 neoplasm of the skin occasional (7.5%) HP:0008069

Drugs & Therapeutics for Syringocystadenoma Papilliferum

About this section

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Syringocystadenoma Papilliferum

Genetic Tests for Syringocystadenoma Papilliferum

About this section

Anatomical Context for Syringocystadenoma Papilliferum

About this section

MalaCards organs/tissues related to Syringocystadenoma Papilliferum:

33
Skin, Prostate, T cells, Pituitary, Breast, Thyroid, Endothelial

Animal Models for Syringocystadenoma Papilliferum or affiliated genes

About this section

MGI Mouse Phenotypes related to Syringocystadenoma Papilliferum:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.4BRAF, KRAS, PORCN, SALL1
2MP:00053718.3KRAS, KRT5, PORCN, SALL1
3MP:00053828.2BRAF, KRAS, KRT5, PORCN
4MP:00053817.8BRAF, KRAS, KRT5, PORCN, SALL1
5MP:00053787.2AZGP1, BRAF, KRAS, KRT5, PORCN, SALL1

Publications for Syringocystadenoma Papilliferum

About this section

Articles related to Syringocystadenoma Papilliferum:

(show top 50)    (show all 144)
idTitleAuthorsYear
1
Cytological diagnosis of syringocystadenoma papilliferum a rare adnexal tumor. (26229253)
2015
2
Fifteen year natural history of lower eyelid syringocystadenoma papilliferum in a young girl. (26097022)
2015
3
Syringocystadenoma papilliferum in an unusual location. (26734876)
2015
4
Activating mutations in the RAS/mitogen-activated protein kinase signaling pathway in sporadic trichoblastoma and syringocystadenoma papilliferum. (25532942)
2015
5
Linear syringocystadenoma papilliferum on female breast: a rare appendageal tumour on an uncommon location. (25756479)
2014
6
Syringocystadenoma papilliferum developing over hyperkeratosis of the nipple in a pregnant woman. (24629369)
2014
7
Syringocystadenoma papilliferum: an unusual presentation. (24995228)
2014
8
Syringocystadenoma papilliferum arising on the scrotum. (22612442)
2013
9
Syringocystadenoma papilliferum of the bony external auditory canal: a rare tumor in a rare location. (23762705)
2013
10
Agminated syringocystadenoma papilliferum: a new clinical presentation of a rare benign adnexal neoplasm. (24021448)
2013
11
Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands: report of a case and review of the literature. (22262361)
2012
12
Adult-onset linear syringocystadenoma papilliferum over the inguinal fold: a case report with emphasis on mast cell staining pattern. (23217957)
2012
13
Basal cell carcinoma, syringocystadenoma papilliferum, trichilemmoma, and sebaceoma arising within a nevus sebaceus associated with pigmented nevi. (22093024)
2011
14
Syringocystadenoma papilliferum of the back combined with a tubular apocrine adenoma. (22148038)
2011
15
Linear syringocystadenoma papilliferum: an uncommon event with a favorable prognosis. (21906485)
2011
16
Lipomatous apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. (21854651)
2011
17
Syringocystadenoma papilliferum on the male nipple. (21914158)
2011
18
A case of zonal syringocystadenoma papilliferum of the axilla mimicking verruca vulgaris. (20098083)
2010
19
Syringocystadenoma papilliferum: an unusual presentation. (20199464)
2009
20
Syringocystadenoma papilliferum-like lesion of the vulva. (18752136)
2008
21
Ductal carcinoma arising from syringocystadenoma papilliferum in the external auditory canal. (17159662)
2007
22
Linear syringocystadenoma papilliferum of the scalp. (17243981)
2007
23
Trichoblastoma and syringocystadenoma papilliferum arising in naevus sebaceous in a 4-year-old boy. (17342802)
2007
24
Syringocystadenoma papilliferum associated with apocrine poroma. (16674787)
2006
25
Basal cell carcinoma and syringocystadenoma papilliferum arising in nevus sebaceus. (16404295)
2006
26
Syringocystadenoma papilliferum: report of 8 cases. (17036946)
2006
27
Syringocystadenoma papilliferum of the eyelid in a young girl. (16418676)
2006
28
A 64-year-old woman with vulvar papule. Vulvar syringocystadenoma papilliferum. (15859658)
2005
29
Tubular apocrine adenoma in association with syringocystadenoma papilliferum. (12639465)
2003
30
Syringocystadenoma papilliferum arising on the scrotum. (12822557)
2003
31
Syringocystadenoma papilliferum mimicking basal cell carcinoma on the lower eyelid: a case report. (12661924)
2002
32
Trichilemmoma and syringocystadenoma papilliferum arising in naevus sebaceous. (12009106)
2002
33
Linear warty papules on the neck of a young woman: syringocystadenoma papilliferum (SP) in a sebaceous nevus (SN). (12164752)
2002
34
Syringocystadenoma papilliferum: a study of potential tumor suppressor genes. (11285401)
2001
35
Mixed syringocystadenoma papilliferum and papillary eccrine adenoma occurring in a scrotal condyloma. (10774942)
2000
36
Syringocystadenoma papilliferum presenting as a cutaneous horn. (10848760)
2000
37
Multiple linear syringocystadenoma papilliferum. (10188162)
1999
38
A case of ductal sweat gland carcinoma connected to syringocystadenoma papilliferum arising in nevus sebaceus. (7699123)
1994
39
Condyloma acuminatum associated with syringocystadenoma papilliferum. (7864300)
1994
40
Fine needle aspiration cytology of chondroid syringoma and syringocystadenoma papilliferum. A report of two cases. (8392255)
1993
41
Syringocystadenoma papilliferum: report of an unusual case. (1661713)
1991
42
A case of tubular apocrine adenoma with syringocystadenoma papilliferum. (2551940)
1989
43
Nevus sebaceus, syringocystadenoma papilliferum, and basal cell epithelioma. (2995466)
1985
44
Syringocystadenoma papilliferum. A plasmacytotropic tumor. (2996375)
1985
45
Pathology quiz case 2: syringocystadenoma papilliferum. (6279032)
1982
46
Syringocystadenoma papilliferum of the eyelid. (6275322)
1981
47
Syringocystadenoma papilliferum in an unusual location. Report of a case. (182084)
1976
48
A mixed tumor occurring as a syringocystadenoma papilliferum with a nevus sebaceus; report of a case. (13486945)
1958
49
Syringocystadenoma papilliferum, nevus sebaceus and basal-cell epithelioma (with features of epithelioma adenoides cysticum and syringoma); their concurrent presence in a single tumor; report of a case. (14901605)
1951
50

Variations for Syringocystadenoma Papilliferum

About this section

Expression for genes affiliated with Syringocystadenoma Papilliferum

About this section
Search GEO for disease gene expression data for Syringocystadenoma Papilliferum.

Pathways for genes affiliated with Syringocystadenoma Papilliferum

About this section

GO Terms for genes affiliated with Syringocystadenoma Papilliferum

About this section

Cellular components related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrionGO:00057399.1BRAF, KRAS, KRT5

Biological processes related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:00435249.4BRAF, KRAS
2somatic stem cell population maintenanceGO:00350199.3BRAF, SALL1

Sources for Syringocystadenoma Papilliferum

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet