MCID: SYR002
MIFTS: 48

Syringocystadenoma Papilliferum malady

Rare diseases, Skin diseases, Cancer diseases categories
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Summaries for Syringocystadenoma Papilliferum

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Wikipedia:65 Syringocystadenoma papilliferum (also known as \"Syringadenoma papilliferum\") is an apocrine tumor. more...

MalaCards based summary: Syringocystadenoma Papilliferum, also known as fistulous vegetative verrucous hydradenoma, is related to hidradenoma and syringoma, and has symptoms including follicular/erythematous/edematous papules/milium, subcutaneous nodules/lipomas/tumefaction/swelling and hypotrichosis/atrichia/atrichiasis/scalp hairlessness. An important gene associated with Syringocystadenoma Papilliferum is PTCH1 (patched 1), and among its related pathways is Striated Muscle Contraction. The compounds 2-methoxyethanol and actomyosin have been mentioned in the context of this disorder. Affiliated tissues include skin and breast.

Aliases & Classifications for Syringocystadenoma Papilliferum

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 62UMLS, 39NCIt, 57SNOMED-CT, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Syringocystadenoma Papilliferum, Aliases & Descriptions:

Name: Syringocystadenoma Papilliferum 8 42 10 48 62
Fistulous Vegetative Verrucous Hydradenoma 42 48
 
Papillary Syringadenoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Skin diseases


Characteristics (Orphanet epidemiological data):

48
syringocystadenoma papilliferum:
Inheritance: Sporadic; Age of onset: Childhood


External Ids:

Disease Ontology8 DOID:5445
NCIt39 C4172
SNOMED-CT57 8934006, 239121009
ICD10 via Orphanet26 D23.9
UMLS via Orphanet63 C0406803

Related Diseases for Syringocystadenoma Papilliferum

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Diseases related to Syringocystadenoma Papilliferum via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1hidradenoma31.2MUC1, CLEC2A, PIP
2syringoma31.1MUC1, S100B
3basal cell carcinoma31.0KRT15, ACTC1, PTCH1, PIP
4sarcoma29.9VIM, MUC1, ACTC1, S100B
5melanoma29.7PTCH1, VIM, ACTC1, PCNA, S100B
6adenoma10.9
7apocrine adenoma10.8
8acanthoma10.5CLEC2A
9hidrocystoma10.4
10histiocytosis10.4S100B
11ganglioglioma10.4S100B
12hemangioma10.4ACTC1
13cystadenocarcinoma10.4MUC1
14spiradenoma10.3CLEC2A, KRT15
15niemann-pick disease10.3
16cystadenoma10.3
17sebaceous adenoma10.3
18focal dermal hypoplasia10.3
19sweat gland carcinoma10.3
20adenoiditis10.3
21adenosquamous carcinoma10.3
22verrucous carcinoma10.3
23embryonal rhabdomyosarcoma10.3PTCH1, ACTC1
24adenomatoid tumor10.3VIM
25alopecia10.3CLEC2A, KRT15
26papilloma10.3ACTC1, PCNA
27cutaneous fibrous histiocytoma10.2ACTC1, S100B
28cutaneous paget's disease10.2PIP, MUC1
29ameloblastoma10.2PCNA, PTCH1
30breast fibroadenoma10.2KRT15, PCNA
31tubular adenocarcinoma10.2ACTC1, MUC1
32fibrous meningioma10.2S100B, MUC1
33choroid plexus papilloma10.2MUC1, S100B
34anaplastic ependymoma10.1MUC1, S100B
35paraganglioma10.1VIM, ACTC1
36bladder carcinoma10.1ACTC1, PTCH1
37microphthalmia10.1ACTC1, S100B
38epithelioid leiomyosarcoma10.1VIM, ACTC1
39hemangioblastoma10.1MUC1, S100B
40pseudosarcomatous fibromatosis10.1VIM, ACTC1
41endometrial stromal sarcoma10.1ACTC1, VIM
42neuroendocrine carcinoma10.1MUC1, S100B
43angiomyolipoma10.1ACTC1, VIM
44fibromatosis10.1ACTC1, VIM
45medulloblastoma10.1S100B, ACTC1, PTCH1
46granular cell tumor10.1VIM, S100B
47clear cell ependymoma10.0VIM, MUC1
48xeroderma pigmentosum10.0PTCH1, PCNA
49mesenchymal chondrosarcoma10.0MUC1, VIM
50malignant peripheral nerve sheath tumor10.0VIM, S100B

Graphical network of the top 20 diseases related to Syringocystadenoma Papilliferum:



Diseases related to syringocystadenoma papilliferum

Symptoms for Syringocystadenoma Papilliferum

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Symptoms:

48
  • follicular/erythematous/edematous papules/milium
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • capillary hemangioma/nevus/naevus flammeus/port-wine stain
  • skin/cutaneous neoplasm/tumor/carcinoma/cancer (excluding melanoma)

HPO human phenotypes related to Syringocystadenoma Papilliferum:

id Description Frequency HPO Source Accession
1 abnormal hair quantity hallmark (90%) HP:0011362
2 abnormal blistering of the skin typical (50%) HP:0008066
3 neoplasm of the skin occasional (7.5%) HP:0008069

Drugs & Therapeutics for Syringocystadenoma Papilliferum

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Drug clinical trials:

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Search NIH Clinical Center for Syringocystadenoma Papilliferum

Genetic Tests for Syringocystadenoma Papilliferum

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Anatomical Context for Syringocystadenoma Papilliferum

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MalaCards organs/tissues related to Syringocystadenoma Papilliferum:

32
Skin, Breast

Animal Models for Syringocystadenoma Papilliferum or affiliated genes

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Publications for Syringocystadenoma Papilliferum

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Articles related to Syringocystadenoma Papilliferum:

(show top 50)    (show all 126)
idTitleAuthorsYear
1
Syringocystadenoma papilliferum developing over hyperkeratosis of the nipple in a pregnant woman. (24629369)
2014
2
Syringocystadenoma papilliferum: an unusual presentation. (24995228)
2014
3
Syringocystadenoma papilliferum arising on the scrotum. (22612442)
2013
4
Syringocystadenoma papilliferum of the bony external auditory canal: a rare tumor in a rare location. (23762705)
2013
5
Agminated syringocystadenoma papilliferum: a new clinical presentation of a rare benign adnexal neoplasm. (24021448)
2013
6
A case of syringocystadenoma papilliferum on lower leg: a rare location. (24082194)
2013
7
Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands: report of a case and review of the literature. (22262361)
2012
8
Adult-onset linear syringocystadenoma papilliferum over the inguinal fold: a case report with emphasis on mast cell staining pattern. (23217957)
2012
9
Basal cell carcinoma, syringocystadenoma papilliferum, trichilemmoma, and sebaceoma arising within a nevus sebaceus associated with pigmented nevi. (22093024)
2011
10
Syringocystadenoma papilliferum of the back combined with a tubular apocrine adenoma. (22148038)
2011
11
Linear syringocystadenoma papilliferum: an uncommon event with a favorable prognosis. (21906485)
2011
12
Lipomatous apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. (21854651)
2011
13
Syringocystadenoma papilliferum on the male nipple. (21914158)
2011
14
Syringocystadenoma papilliferum: Unusual location. (21696687)
2011
15
A case of zonal syringocystadenoma papilliferum of the axilla mimicking verruca vulgaris. (20098083)
2010
16
Syringocystadenoma papilliferum: an unusual presentation. (20199464)
2009
17
Syringocystadenoma papilliferum-like lesion of the vulva. (18752136)
2008
18
Ductal carcinoma arising from syringocystadenoma papilliferum in the external auditory canal. (17159662)
2007
19
Linear syringocystadenoma papilliferum of the scalp. (17243981)
2007
20
Trichoblastoma and syringocystadenoma papilliferum arising in naevus sebaceous in a 4-year-old boy. (17342802)
2007
21
Syringocystadenoma papilliferum associated with apocrine poroma. (16674787)
2006
22
Basal cell carcinoma and syringocystadenoma papilliferum arising in nevus sebaceus. (16404295)
2006
23
Syringocystadenoma papilliferum: report of 8 cases. (17036946)
2006
24
Syringocystadenoma papilliferum of the eyelid in a young girl. (16418676)
2006
25
Syringocystadenoma papilliferum: a rare breast tumor in a young boy. (16953682)
2006
26
A 64-year-old woman with vulvar papule. Vulvar syringocystadenoma papilliferum. (15859658)
2005
27
Tubular apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. (16354370)
2005
28
Tubular apocrine adenoma in association with syringocystadenoma papilliferum. (12639465)
2003
29
Syringocystadenoma papilliferum arising on the scrotum. (12822557)
2003
30
Syringocystadenoma papilliferum mimicking basal cell carcinoma on the lower eyelid: a case report. (12661924)
2002
31
Trichilemmoma and syringocystadenoma papilliferum arising in naevus sebaceous. (12009106)
2002
32
Linear warty papules on the neck of a young woman: syringocystadenoma papilliferum (SP) in a sebaceous nevus (SN). (12164752)
2002
33
Syringocystadenoma papilliferum: a study of potential tumor suppressor genes. (11285401)
2001
34
Mixed syringocystadenoma papilliferum and papillary eccrine adenoma occurring in a scrotal condyloma. (10774942)
2000
35
Syringocystadenoma papilliferum presenting as a cutaneous horn. (10848760)
2000
36
Syringocystadenoma papilliferum mimicking breast carcinoma. (10698227)
2000
37
Multiple linear syringocystadenoma papilliferum. (10188162)
1999
38
A case of ductal sweat gland carcinoma connected to syringocystadenoma papilliferum arising in nevus sebaceus. (7699123)
1994
39
Condyloma acuminatum associated with syringocystadenoma papilliferum. (7864300)
1994
40
Fine needle aspiration cytology of chondroid syringoma and syringocystadenoma papilliferum. A report of two cases. (8392255)
1993
41
Syringocystadenoma papilliferum: report of an unusual case. (1661713)
1991
42
A case of tubular apocrine adenoma with syringocystadenoma papilliferum. (2551940)
1989
43
Nevus sebaceus, syringocystadenoma papilliferum, and basal cell epithelioma. (2995466)
1985
44
Syringocystadenoma papilliferum. A plasmacytotropic tumor. (2996375)
1985
45
Pathology quiz case 2: syringocystadenoma papilliferum. (6279032)
1982
46
Syringocystadenoma papilliferum of the eyelid. (6275322)
1981
47
Syringocystadenoma papilliferum in an unusual location. Report of a case. (182084)
1976
48
Syringocystadenoma papilliferum: light and electron microscopic studies. (78616)
1976
49
A mixed tumor occurring as a syringocystadenoma papilliferum with a nevus sebaceus; report of a case. (13486945)
1958
50
Syringocystadenoma papilliferum, nevus sebaceus and basal-cell epithelioma (with features of epithelioma adenoides cysticum and syringoma); their concurrent presence in a single tumor; report of a case. (14901605)
1951

Variations for Syringocystadenoma Papilliferum

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Expression for genes affiliated with Syringocystadenoma Papilliferum

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Expression patterns in normal tissues for genes affiliated with Syringocystadenoma Papilliferum

Search GEO for disease gene expression data for Syringocystadenoma Papilliferum.

Pathways for genes affiliated with Syringocystadenoma Papilliferum

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Pathways related to Syringocystadenoma Papilliferum according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7ACTC1, VIM

Compounds for genes affiliated with Syringocystadenoma Papilliferum

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Compounds related to Syringocystadenoma Papilliferum according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
12-methoxyethanol4410.0ACTC1, VIM
2actomyosin449.9VIM, ACTC1
3temozolomide44 1110.8PCNA, VIM
43-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.8PCNA, S100B
5orcein449.7VIM, ACTC1, S100B
6roscovitine449.7VIM, PCNA
74-hydroxytamoxifen449.6S100B, VIM
8matrigel449.6VIM, MUC1, ACTC1
9chloramphenicol44 2 50 1112.6VIM, MUC1, S100B
10calcipotriol44 61 28 1112.5KRT15, VIM
11procollagen449.5VIM, ACTC1, PCNA
12bromodeoxyuridine449.5VIM, PCNA, S100B
13cytarabine44 50 1111.5PCNA, MUC1, VIM
14forskolin44 50 1111.4S100B, MUC1, VIM
15methotrexate50 44 1111.4VIM, MUC1, PCNA
16etoposide44 50 61 1112.4S100B, PCNA, VIM
17paclitaxel44 50 1111.4S100B, PCNA, VIM
18cyclosporin a44 28 6111.4S100B, PCNA, ACTC1
19butyrate449.4VIM, MUC1, PCNA
20iron44 2410.4S100B, ACTC1, VIM
21hydroxyapatite449.3S100B, VIM
22dihydrotestosterone44 28 24 1112.3MUC1, VIM, PIP
23s 100449.3S100B, ACTC1, MUC1, VIM
24glycogen44 2410.3S100B, ACTC1, MUC1, VIM
25glutamine449.2VIM, PCNA, S100B
26biotin44 24 1111.2VIM, MUC1, ACTC1, PCNA
27eosin449.1VIM, MUC1, PCNA, S100B
28lactate449.1VIM, PCNA, S100B
29thymidine44 2410.1S100B, PCNA, MUC1
30cysteine449.0S100B, PCNA, MUC1, VIM
31tamoxifen44 50 28 1111.9PIP, VIM, MUC1, PCNA
32estradiol44 24 1110.8PCNA, MUC1, VIM, PIP
33reticulin448.8VIM, MUC1, ACTC1, PCNA, S100B
34hematoxylin448.8VIM, MUC1, ACTC1, PCNA, S100B
35formaldehyde44 249.8S100B, PCNA, ACTC1, MUC1, VIM
36creatinine448.8VIM, MUC1, ACTC1, PCNA, S100B
37dexamethasone44 50 28 1111.8S100B, PCNA, ACTC1, MUC1, VIM
38vegf448.8VIM, MUC1, ACTC1, PCNA, S100B
39mucicarmine448.7PIP, VIM, MUC1, ACTC1, S100B
40tyrosine448.5KRT15, S100B, ACTC1, MUC1, PTCH1
41b 723448.2S100B, PCNA, ACTC1, MUC1, VIM, PIP
42progesterone44 28 61 24 1112.2PIP, VIM, MUC1, ACTC1, PCNA, S100B
43testosterone44 61 24 1111.2PIP, VIM, MUC1, ACTC1, PCNA, S100B
44estrogen448.2PIP, VIM, MUC1, ACTC1, PCNA, S100B
45retinoic acid44 248.9VIM, MUC1, ACTC1, PCNA, S100B, KRT15
46paraffin447.9PIP, PTCH1, VIM, MUC1, ACTC1, PCNA

GO Terms for genes affiliated with Syringocystadenoma Papilliferum

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Cellular components related to Syringocystadenoma Papilliferum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700627.3KRT15, PCNA, ACTC1, MUC1, VIM, PIP

Biological processes related to Syringocystadenoma Papilliferum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.7ACTC1, VIM

Molecular functions related to Syringocystadenoma Papilliferum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:0019489.4PIP, VIM
2scaffold protein bindingGO:0971109.1VIM, KRT15
3protein bindingGO:0055156.7PTCH1, CLEC2A, VIM, MUC1, PCNA, S100B

Products for genes affiliated with Syringocystadenoma Papilliferum

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Sources for Syringocystadenoma Papilliferum

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet