MCID: SYR002
MIFTS: 47

Syringocystadenoma Papilliferum malady

Rare diseases, Skin diseases, Cancer diseases categories
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Summaries for Syringocystadenoma Papilliferum

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65Wikipedia, 33MalaCards
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Wikipedia:65 Syringocystadenoma papilliferum (also known as \"Syringadenoma papilliferum\") is an apocrine tumor. more...

MalaCards: Syringocystadenoma Papilliferum, also known as fistulous vegetative verrucous hydradenoma, is related to basal cell carcinoma and hidradenoma, and has symptoms including subcutaneous nodules/lipomas/tumefaction/swelling, follicular/erythematous/edematous papules/milium and vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment. An important gene associated with Syringocystadenoma Papilliferum is PTCH1 (patched 1), and among its related pathways is Striated Muscle Contraction. The compounds 2-methoxyethanol and actomyosin have been mentioned in the context of this disorder. Affiliated tissues include skin and breast.

Aliases & Classifications for Syringocystadenoma Papilliferum

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 62UMLS, 58SNOMED-CT, 40NCIt, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Skin diseases


Characteristics (Orphanet epidemiological data):

49
syringocystadenoma papilliferum:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

syringocystadenoma papilliferum 8 43 10 49 62
fistulous vegetative verrucous hydradenoma 43 49
papillary syringadenoma 8


External Ids:

Disease Ontology8 DOID:5445
NCIt40 C4172
ICD10 via Orphanet26 D23.9
SNOMED-CT58 239121009, 8934006
SNOMED-CT via Orphanet59 239121009
UMLS via Orphanet63 C0406803

Related Diseases for Syringocystadenoma Papilliferum

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17GeneCards, 18GeneDecks
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Diseases related to Syringocystadenoma Papilliferum via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1basal cell carcinoma31.0ACTC1, KRT15, PTCH1, PIP
2hidradenoma31.0PIP, CLEC2A, MUC1
3syringoma30.8MUC1, S100B
4leiomyosarcoma30.3VIM, MUC1, ACTC1, S100B
5melanoma30.2PTCH1, ACTC1, PCNA, S100B, VIM
6adenoma10.8
7apocrine adenoma10.8
8hidrocystoma10.4
9cystadenoma10.3
10sebaceous adenoma10.3
11focal dermal hypoplasia10.3
12cutaneous leiomyosarcoma10.3
13adenoiditis10.3
14sweat gland carcinoma10.3
15verrucous carcinoma10.3
16adenosquamous carcinoma10.3
17niemann-pick disease10.3
18acanthoma10.1CLEC2A
19histiocytosis10.1S100B
20ganglioglioma10.1S100B
21hemangioma10.1ACTC1
22cystadenocarcinoma10.1MUC1
23spiradenoma10.1KRT15, CLEC2A
24embryonal rhabdomyosarcoma10.1PTCH1, ACTC1
25adenomatoid tumor10.1VIM
26alopecia10.1KRT15, CLEC2A
27papilloma10.1ACTC1, PCNA
28cutaneous fibrous histiocytoma10.1ACTC1, S100B
29cutaneous paget's disease10.1PIP, MUC1
30adenoameloblastoma10.0PCNA, PTCH1
31breast fibroadenoma10.0PCNA, KRT15
32tubular adenocarcinoma10.0MUC1, ACTC1
33fibrous meningioma10.0MUC1, S100B
34anaplastic ependymoma10.0S100B, MUC1
35choroid plexus papilloma10.0S100B, MUC1
36glomus tumor10.0VIM, ACTC1
37microphthalmia10.0ACTC1, S100B
38bladder carcinoma10.0PTCH1, ACTC1
39epithelioid leiomyosarcoma10.0ACTC1, VIM
40hemangioblastoma10.0MUC1, S100B
41pseudosarcomatous fibromatosis10.0VIM, ACTC1
42endometrial stromal sarcoma10.0VIM, ACTC1
43neuroendocrine carcinoma10.0MUC1, S100B
44angiomyolipoma10.0ACTC1, VIM
45fibromatosis10.0ACTC1, VIM
46medulloblastoma10.0S100B, PTCH1, ACTC1
47granular cell tumor10.0VIM, S100B
48clear cell ependymoma10.0VIM, MUC1
49xeroderma pigmentosum10.0PCNA, PTCH1
50mesenchymal chondrosarcoma10.0VIM, MUC1

Graphical network of the top 20 diseases related to Syringocystadenoma Papilliferum:



Diseases related to syringocystadenoma papilliferum

Symptoms for Syringocystadenoma Papilliferum

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49Orphanet
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Symptoms:

49
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • follicular/erythematous/edematous papules/milium
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • capillary hemangioma/nevus/naevus flammeus/port-wine stain
  • skin/cutaneous neoplasm/tumor/carcinoma/cancer (excluding melanoma)

Drugs & Therapeutics for Syringocystadenoma Papilliferum

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Syringocystadenoma Papilliferum

Search NIH Clinical Center for Syringocystadenoma Papilliferum

Genetic Tests for Syringocystadenoma Papilliferum

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Anatomical Context for Syringocystadenoma Papilliferum

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33MalaCards
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MalaCards organs/tissues related to Syringocystadenoma Papilliferum:

33
Skin, Breast

Animal Models for Syringocystadenoma Papilliferum or affiliated genes

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Publications for Syringocystadenoma Papilliferum

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52PubMed
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Articles related to Syringocystadenoma Papilliferum:

(show top 50)    (show all 122)
idTitleAuthorsYear
1
Syringocystadenoma papilliferum arising on the scrotum. (22612442)
2013
2
Syringocystadenoma papilliferum of the bony external auditory canal: a rare tumor in a rare location. (23762705)
2013
3
Agminated syringocystadenoma papilliferum: a new clinical presentation of a rare benign adnexal neoplasm. (24021448)
2013
4
A case of syringocystadenoma papilliferum on lower leg: a rare location. (24082194)
2013
5
Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands: report of a case and review of the literature. (22262361)
2012
6
Adult-onset linear syringocystadenoma papilliferum over the inguinal fold: a case report with emphasis on mast cell staining pattern. (23217957)
2012
7
Basal cell carcinoma, syringocystadenoma papilliferum, trichilemmoma, and sebaceoma arising within a nevus sebaceus associated with pigmented nevi. (22093024)
2011
8
Syringocystadenoma papilliferum of the back combined with a tubular apocrine adenoma. (22148038)
2011
9
Linear syringocystadenoma papilliferum: an uncommon event with a favorable prognosis. (21906485)
2011
10
Lipomatous apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. (21854651)
2011
11
Syringocystadenoma papilliferum on the male nipple. (21914158)
2011
12
Syringocystadenoma papilliferum: Unusual location. (21696687)
2011
13
A case of zonal syringocystadenoma papilliferum of the axilla mimicking verruca vulgaris. (20098083)
2010
14
Syringocystadenoma papilliferum: an unusual presentation. (20199464)
2009
15
Syringocystadenoma papilliferum-like lesion of the vulva. (18752136)
2008
16
Congenital syringocystadenoma papilliferum. (18304179)
2008
17
Ductal carcinoma arising from syringocystadenoma papilliferum in the external auditory canal. (17159662)
2007
18
Trichoblastoma and syringocystadenoma papilliferum arising in naevus sebaceous in a 4-year-old boy. (17342802)
2007
19
Syringocystadenoma papilliferum associated with apocrine poroma. (16674787)
2006
20
Basal cell carcinoma and syringocystadenoma papilliferum arising in nevus sebaceus. (16404295)
2006
21
Syringocystadenoma papilliferum: report of 8 cases. (17036946)
2006
22
Syringocystadenoma papilliferum of the eyelid in a young girl. (16418676)
2006
23
Syringocystadenoma papilliferum: a rare breast tumor in a young boy. (16953682)
2006
24
A 64-year-old woman with vulvar papule. Vulvar syringocystadenoma papilliferum. (15859658)
2005
25
Tubular apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. (16354370)
2005
26
Tubular apocrine adenoma in association with syringocystadenoma papilliferum. (12639465)
2003
27
Syringocystadenoma papilliferum arising on the scrotum. (12822557)
2003
28
Syringocystadenoma papilliferum mimicking basal cell carcinoma on the lower eyelid: a case report. (12661924)
2002
29
Trichilemmoma and syringocystadenoma papilliferum arising in naevus sebaceous. (12009106)
2002
30
Linear warty papules on the neck of a young woman: syringocystadenoma papilliferum (SP) in a sebaceous nevus (SN). (12164752)
2002
31
Syringocystadenoma papilliferum: a study of potential tumor suppressor genes. (11285401)
2001
32
Mixed syringocystadenoma papilliferum and papillary eccrine adenoma occurring in a scrotal condyloma. (10774942)
2000
33
Syringocystadenoma papilliferum presenting as a cutaneous horn. (10848760)
2000
34
Syringocystadenoma papilliferum mimicking breast carcinoma. (10698227)
2000
35
Multiple linear syringocystadenoma papilliferum. (10188162)
1999
36
Syringocystadenoma papilliferum without an antecedent naevus sebaceous. (10384930)
1999
37
A case of ductal sweat gland carcinoma connected to syringocystadenoma papilliferum arising in nevus sebaceus. (7699123)
1994
38
Condyloma acuminatum associated with syringocystadenoma papilliferum. (7864300)
1994
39
Fine needle aspiration cytology of chondroid syringoma and syringocystadenoma papilliferum. A report of two cases. (8392255)
1993
40
Syringocystadenoma papilliferum: report of an unusual case. (1661713)
1991
41
A case of tubular apocrine adenoma with syringocystadenoma papilliferum. (2551940)
1989
42
Nevus sebaceus, syringocystadenoma papilliferum, and basal cell epithelioma. (2995466)
1985
43
Syringocystadenoma papilliferum. A plasmacytotropic tumor. (2996375)
1985
44
Congenital papillated apocrine cystadenoma: a mixed form of hidrocystoma, hidradenoma papilliferum, and syringocystadenoma papilliferum. (6090513)
1984
45
Pathology quiz case 2: syringocystadenoma papilliferum. (6279032)
1982
46
Syringocystadenoma papilliferum of the eyelid. (6275322)
1981
47
Syringocystadenoma papilliferum in an unusual location. Report of a case. (182084)
1976
48
Syringocystadenoma papilliferum: light and electron microscopic studies. (78616)
1976
49
A mixed tumor occurring as a syringocystadenoma papilliferum with a nevus sebaceus; report of a case. (13486945)
1958
50
Syringocystadenoma papilliferum, nevus sebaceus and basal-cell epithelioma (with features of epithelioma adenoides cysticum and syringoma); their concurrent presence in a single tumor; report of a case. (14901605)
1951

Variations for Syringocystadenoma Papilliferum

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Expression for genes affiliated with Syringocystadenoma Papilliferum

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Syringocystadenoma Papilliferum

Search GEO for disease gene expression data for Syringocystadenoma Papilliferum.

Pathways for genes affiliated with Syringocystadenoma Papilliferum

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50PathCards, 38NCBI BioSystems Database, 55Reactome
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Pathways related to Syringocystadenoma Papilliferum according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7ACTC1, VIM

Compounds for genes affiliated with Syringocystadenoma Papilliferum

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Sources:
45Novoseek, 11DrugBank, 3BitterDB, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Syringocystadenoma Papilliferum according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
12-methoxyethanol4510.0ACTC1, VIM
2actomyosin459.9VIM, ACTC1
3temozolomide45 1110.8PCNA, VIM
43-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.8PCNA, S100B
5orcein459.7VIM, ACTC1, S100B
6roscovitine459.7VIM, PCNA
74-hydroxytamoxifen459.6S100B, VIM
8matrigel459.6VIM, MUC1, ACTC1
9chloramphenicol45 3 51 1112.6VIM, MUC1, S100B
10calcipotriol45 61 29 1112.5KRT15, VIM
11procollagen459.5VIM, ACTC1, PCNA
12bromodeoxyuridine459.5VIM, PCNA, S100B
13cytarabine45 51 1111.5PCNA, MUC1, VIM
14forskolin45 51 1111.4S100B, MUC1, VIM
15methotrexate51 45 1111.4VIM, MUC1, PCNA
16etoposide45 51 61 1112.4S100B, PCNA, VIM
17paclitaxel45 51 1111.4S100B, PCNA, VIM
18cyclosporin a45 29 6111.4S100B, PCNA, ACTC1
19butyrate459.4VIM, MUC1, PCNA
20iron45 2410.4S100B, ACTC1, VIM
21hydroxyapatite459.3S100B, VIM
22dihydrotestosterone45 29 24 1112.3MUC1, VIM, PIP
23s 100459.3S100B, ACTC1, MUC1, VIM
24glycogen45 2410.3S100B, ACTC1, MUC1, VIM
25glutamine459.2VIM, PCNA, S100B
26biotin45 24 1111.2VIM, MUC1, ACTC1, PCNA
27eosin459.1VIM, MUC1, PCNA, S100B
28lactate459.1VIM, PCNA, S100B
29thymidine45 2410.1S100B, PCNA, MUC1
30cysteine459.0S100B, PCNA, MUC1, VIM
31tamoxifen45 51 29 1111.9PIP, VIM, MUC1, PCNA
32estradiol45 24 1110.8PCNA, MUC1, VIM, PIP
33reticulin458.8VIM, MUC1, ACTC1, PCNA, S100B
34hematoxylin458.8VIM, MUC1, ACTC1, PCNA, S100B
35formaldehyde45 249.8S100B, PCNA, ACTC1, MUC1, VIM
36creatinine458.8VIM, MUC1, ACTC1, PCNA, S100B
37dexamethasone45 51 29 1111.8S100B, PCNA, ACTC1, MUC1, VIM
38vegf458.8VIM, MUC1, ACTC1, PCNA, S100B
39mucicarmine458.7PIP, VIM, MUC1, ACTC1, S100B
40tyrosine458.5KRT15, S100B, ACTC1, MUC1, PTCH1
41b 723458.2S100B, PCNA, ACTC1, MUC1, VIM, PIP
42progesterone45 29 61 24 1112.2PIP, VIM, MUC1, ACTC1, PCNA, S100B
43testosterone45 61 24 1111.2PIP, VIM, MUC1, ACTC1, PCNA, S100B
44estrogen458.2PIP, VIM, MUC1, ACTC1, PCNA, S100B
45retinoic acid45 248.9VIM, MUC1, ACTC1, PCNA, S100B, KRT15
46paraffin457.9PIP, PTCH1, VIM, MUC1, ACTC1, PCNA

GO Terms for genes affiliated with Syringocystadenoma Papilliferum

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16Gene Ontology
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Cellular components related to Syringocystadenoma Papilliferum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700627.3KRT15, PCNA, ACTC1, MUC1, VIM, PIP

Biological processes related to Syringocystadenoma Papilliferum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.7ACTC1, VIM

Molecular functions related to Syringocystadenoma Papilliferum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:0019489.4VIM, PIP
2scaffold protein bindingGO:0971109.1KRT15, VIM
3protein bindingGO:0055156.7PTCH1, CLEC2A, VIM, MUC1, PCNA, S100B

Products for genes affiliated with Syringocystadenoma Papilliferum

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Sources for Syringocystadenoma Papilliferum

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet