MCID: SYR002
MIFTS: 39

Syringocystadenoma Papilliferum malady

Skin, Cancer categories

Summaries for Syringocystadenoma Papilliferum

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Syringocystadenoma papilliferum (also known as \"Syringadenoma papilliferum\") is an apocrine tumor. more...

MalaCards: Syringocystadenoma Papilliferum, also known as fistulous vegetative verrucous hydradenoma, is related to adenoma and basal cell carcinoma, and has symptoms including follicular/erythematous/edematous papules/milium, subcutaneous nodules/lipomas/tumefaction/swelling and hypotrichosis/atrichia/atrichiasis/scalp hairlessness. An important gene associated with Syringocystadenoma Papilliferum is ACTC1 (actin, alpha, cardiac muscle 1). The compounds 2-methoxyethanol and orcein have been mentioned in the context of this disorder. Affiliated tissues include breast.

Aliases & Classifications for Syringocystadenoma Papilliferum

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 61UMLS, 40NCIt, 57SNOMED-CT, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Skin


Characteristics (Orphanet epidemiological data):

49
syringocystadenoma papilliferum:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

syringocystadenoma papilliferum 8 43 10 49 61
fistulous vegetative verrucous hydradenoma 43 49
papillary syringadenoma 8


External Ids:

Disease Ontology8 DOID:5445
NCIt40 C4172
ICD10 via Orphanet26 D23.9
SNOMED-CT57 239121009, 8934006
SNOMED-CT via Orphanet58 239121009
UMLS via Orphanet62 C0406803

Related Diseases for Syringocystadenoma Papilliferum

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Syringocystadenoma Papilliferum via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.1ACTC1, PCNA, MUC1
2basal cell carcinoma30.9PTCH1, ACTC1, KRT15, PIP
3syringoma30.7MUC1, S100B
4hidrocystoma30.5PIP, SGTA
5mucoepidermoid carcinoma30.3ACTC1, PCNA, MUC1
6squamous cell carcinoma30.3VIM, PIP, MUC1, PCNA, KRT15, ACTC1
7apocrine adenoma10.7
8niemann-pick disease10.2
9sebaceous adenoma10.2
10cystadenoma10.2
11eye carcinoma10.2
12sweat gland carcinoma10.2
13focal dermal hypoplasia10.2
14follicular infundibulum tumor10.2
15eccrine papillary adenoma10.2
16eyelid carcinoma10.2
17pick's disease10.2
18breast apocrine adenoma10.2
19pigmented basal cell carcinoma10.2
20sebaceous basal cell carcinoma10.2
21cutaneous leiomyosarcoma10.2
22verrucous carcinoma10.2
23adenosquamous carcinoma10.2
24papillary adenoma10.2
25breast adenoma10.2
26niemann–pick disease10.2
27fasciitis10.0ACTC1
28li-fraumeni syndrome10.0PIP
29psoriasis10.0KRT15
30acanthoma10.0CLEC2A
31familial adenomatous polyposis10.0PTCH1
32thyroid cancer10.0PTCH1
33paraganglioma10.0S100B
34teratoma10.0ACTC1
35keratosis10.0CLEC2A
36hemangioma10.0ACTC1
37endometriosis10.0ACTC1
38histiocytosis10.0S100B
39benign meningioma10.0PCNA
40endometrial carcinoma10.0PCNA
41spiradenoma10.0KRT15, CLEC2A
42cystadenocarcinoma10.0MUC1
43pituitary adenoma10.0PCNA
44alopecia10.0CLEC2A, KRT15
45nevoid basal cell carcinoma syndrome10.0PTCH1
46oligodendroglioma10.0PCNA
47lymphangioma10.0ACTC1
48laryngeal carcinoma10.0PCNA
49desmoid tumor10.0ACTC1
50papilloma10.0ACTC1, PCNA

Graphical network of the top 20 diseases related to Syringocystadenoma Papilliferum:



Diseases related to syringocystadenoma papilliferum

Clinical Features for Syringocystadenoma Papilliferum

Sources:
49Orphanet
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Symptoms:

49 (show all 6)
  • follicular/erythematous/edematous papules/milium
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • capillary hemangioma/nevus/naevus flammeus/port-wine stain
  • skin/cutaneous neoplasm/tumor/carcinoma/cancer (excluding melanoma)

Drugs & Therapeutics for Syringocystadenoma Papilliferum

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Syringocystadenoma Papilliferum

Drug clinical trials:

Search ClinicalTrials for Syringocystadenoma Papilliferum

Search NIH Clinical Center for Syringocystadenoma Papilliferum

Search CenterWatch for Syringocystadenoma Papilliferum

Genetic Tests for Syringocystadenoma Papilliferum

Anatomical Context for Syringocystadenoma Papilliferum

Sources:
33MalaCards
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MalaCards organs/tissues related to Syringocystadenoma Papilliferum:

33
Breast

Animal Models for Syringocystadenoma Papilliferum or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Syringocystadenoma Papilliferum

Sources:
51PubMed
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Articles related to Syringocystadenoma Papilliferum:

(show top 50)    (show all 124)
idTitleAuthorsYear
1
Syringocystadenoma papilliferum of the bony external auditory canal: a rare tumor in a rare location. (23762705)
2013
2
Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands: report of a case and review of the literature. (22262361)
2012
3
Giant linear syringocystadenoma papilliferum of the back. (22199089)
2012
4
Basal cell carcinoma, syringocystadenoma papilliferum, trichilemmoma, and sebaceoma arising within a nevus sebaceus associated with pigmented nevi. (22093024)
2011
5
Lipomatous apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. (21854651)
2011
6
Syringocystadenoma papilliferum on the male nipple. (21914158)
2011
7
Dermoscopic aspects of syringocystadenoma papilliferum associated with nevus sebaceus. (22281917)
2011
8
Syringocystadenoma papilliferum. (22372162)
2011
9
Syringocystadenoma papilliferum: an unusual presentation. (20199464)
2009
10
Syringocystadenoma papilliferum of the eyelid. (19454927)
2009
11
Scrotal syringocystadenoma papilliferum: case report. (19497181)
2009
12
Syringocystadenoma papilliferum in a patient with focal dermal hypoplasia due to a novel PORCN mutation. (19221286)
2009
13
Syringocystadenoma papilliferum on the thigh: an unusual location. (19293506)
2009
14
Giant condyloma acuminata with syringocystadenoma papilliferum. (19439910)
2009
15
Linear papules and nodules on the neck. Syringocystadenoma papilliferum (SP). (19015430)
2008
16
Sebaceoma, trichoblastoma and syringocystadenoma papilliferum arising within a nevus sebaceous. (18578715)
2008
17
Ductal carcinoma arising from syringocystadenoma papilliferum in the external auditory canal. (17159662)
2007
18
Tubular adenoma and syringocystadenoma papilliferum: a reappraisal of their relationship. An interobserver study of a series, by a panel of dermatopathologists. (17519623)
2007
19
Syringocystadenoma papilliferum: report of first case on the pinna. (17105677)
2006
20
Giant naevoid syringocystadenoma papilliferum. (16159744)
2005
21
Keratinizing squamous epithelium associated with Syringocystadenoma papilliferum differentiates towards infrainfundibulum: case report with immunohistochemical study of cytokeratins. (16222893)
2005
22
Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands. (15268713)
2004
23
Tubular apocrine adenoma in association with syringocystadenoma papilliferum. (12639465)
2003
24
Syringocystadenoma papilliferum arising on the scrotum. (12822557)
2003
25
Multiple pigmented trichoblastomas and syringocystadenoma papilliferum in naevus sebaceous mimicking a malignant melanoma: a clinical dermoscopic-pathological case study. (14632818)
2003
26
A case of syringocystadenocarcinoma papilliferum in situ occurring partially in syringocystadenoma papilliferum. (12692383)
2003
27
Syringocystadenoma papilliferum contiguous to a verrucous cyst. (12534802)
2003
28
Mixed tubulopapillary hidradenoma and syringocystadenoma papilliferum occurring as a verrucous tumor. (12641782)
2003
29
Linear warty papules on the neck of a young woman: syringocystadenoma papilliferum (SP) in a sebaceous nevus (SN). (12164752)
2002
30
Nevus comedonicus with hidradenoma papilliferum and syringocystadenoma papilliferum in the female genital area. (12530358)
2002
31
Syringocystadenoma papilliferum: a study of potential tumor suppressor genes. (11285401)
2001
32
Linear syringocystadenoma papilliferum of the thigh. (11423852)
2001
33
Mixed syringocystadenoma papilliferum and papillary eccrine adenoma occurring in a scrotal condyloma. (10774942)
2000
34
Syringocystadenoma papilliferum of the male breast. (9700386)
1998
35
Syringocystadenoma papilliferum, basal cell carcinoma and trichilemmoma arising from nevus sebaceus of Jadassohn. (9188887)
1997
36
An unusual case of syringocystadenoma papilliferum of the eyelid. (9018997)
1996
37
Congenital syringocystadenoma papilliferum of the ear and neck treated with the CO2 laser. (9119597)
1996
38
Condyloma acuminatum associated with syringocystadenoma papilliferum. (7864300)
1994
39
Fine needle aspiration cytology of chondroid syringoma and syringocystadenoma papilliferum. A report of two cases. (8392255)
1993
40
Syringocystadenoma papilliferum: report of an unusual case. (1661713)
1991
41
Syringocystadenoma papilliferum associated with poroma folliculare. (3031142)
1986
42
Syringocystadenoma papilliferum. A plasmacytotropic tumor. (2996375)
1985
43
Congenital papillated apocrine cystadenoma: a mixed form of hidrocystoma, hidradenoma papilliferum, and syringocystadenoma papilliferum. (6090513)
1984
44
Pathology quiz case 2: syringocystadenoma papilliferum. (6279032)
1982
45
Syringocystadenoma papilliferum of the eyelid. (6275322)
1981
46
Syringocystadenoma papilliferum in an unusual location. Report of a case. (182084)
1976
47
Nevus sebaceous and syringocystadenoma papilliferum. (183608)
1976
48
Syringocystadenoma papilliferum. An electron microscopic study. (4345083)
1972
49
Nevus sebaceus of Jadassohn with associated syringocystadenoma papilliferum. (4375514)
1971
50
Syringocystadenoma papilliferum, nevus sebaceus and basal-cell epithelioma (with features of epithelioma adenoides cysticum and syringoma); their concurrent presence in a single tumor; report of a case. (14901605)
1951

Genetic Variations for Syringocystadenoma Papilliferum

Expression for genes affiliated with Syringocystadenoma Papilliferum

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Syringocystadenoma Papilliferum

Search GEO for disease gene expression data for Syringocystadenoma Papilliferum.

Pathways for genes affiliated with Syringocystadenoma Papilliferum

Compounds for genes affiliated with Syringocystadenoma Papilliferum

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Syringocystadenoma Papilliferum according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
12-methoxyethanol4510.0VIM, ACTC1
2orcein459.8VIM, S100B, ACTC1
3calcipotriol45 60 29 1112.5KRT15, VIM
4procollagen459.5ACTC1, PCNA, VIM
5s 100459.5S100B, VIM, ACTC1, MUC1
6temozolomide45 1110.4PCNA, VIM
7cytarabine45 50 1111.4PCNA, VIM, MUC1
8chloramphenicol45 2 1111.4MUC1, S100B, VIM
9bromodeoxyuridine459.3PCNA, VIM, S100B
10glycogen45 2410.3ACTC1, MUC1, VIM, S100B
11eosin459.2VIM, S100B, MUC1, PCNA
12biotin45 11 2411.2VIM, MUC1, ACTC1, PCNA
13dihydrotestosterone45 29 11 2412.1VIM, PIP, MUC1
14reticulin458.9VIM, S100B, ACTC1, PCNA, MUC1
15hematoxylin458.9ACTC1, VIM, S100B, MUC1, PCNA
16formaldehyde45 249.9ACTC1, PCNA, VIM, MUC1, S100B
17creatinine458.9MUC1, S100B, ACTC1, PCNA, VIM
18methotrexate45 50 1110.9VIM, PCNA, MUC1
19dexamethasone45 50 29 1111.8S100B, ACTC1, PCNA, MUC1, VIM
20mucicarmine458.8MUC1, ACTC1, PIP, S100B, VIM
21tamoxifen45 50 29 1111.8MUC1, PCNA, VIM, PIP
22vegf458.8VIM, S100B, MUC1, PCNA, ACTC1
23estradiol45 11 2410.8PCNA, VIM, PIP, MUC1
24retinoic acid45 249.3PCNA, ACTC1, MUC1, KRT15, S100B, VIM
25b 723458.3MUC1, ACTC1, VIM, S100B, PIP, PCNA
26progesterone45 60 29 11 2412.3MUC1, ACTC1, PCNA, S100B, VIM, PIP
27cysteine458.2MUC1, S100B, PCNA, SGTA, VIM
28paraffin458.0PCNA, MUC1, PIP, S100B, VIM, ACTC1
29testosterone45 60 11 2410.9VIM, SCAP, PIP, MUC1, PCNA, ACTC1

GO Terms for genes affiliated with Syringocystadenoma Papilliferum

Sources:
16Gene Ontology
See all sources

Molecular functions related to Syringocystadenoma Papilliferum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.5KRT15, VIM
2protein bindingGO:0055156.1PTCH1, VIM, S100B, SCAP, MUC1, PCNA

Products for genes affiliated with Syringocystadenoma Papilliferum

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Sources for Syringocystadenoma Papilliferum

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet