MCID: SYR002
MIFTS: 42

Syringocystadenoma Papilliferum malady

Categories: Rare diseases, Skin diseases, Cancer diseases

Aliases & Classifications for Syringocystadenoma Papilliferum

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Sources:
11Disease Ontology, 13DISEASES, 31ICD10 via Orphanet, 45NCIt, 48NIH Rare Diseases, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Syringocystadenoma Papilliferum:

Name: Syringocystadenoma Papilliferum 11 48 54 13 68
Fistulous Vegetative Verrucous Hydradenoma 48 54
Naevus Syringocystadenomatosus Papilliferus 54
Syringadenoma Papilliferum 54
 
Papillary Syringadenoma 11
Papillary Hidradenoma 68
Scap 54

Characteristics:

Orphanet epidemiological data:

54
syringocystadenoma papilliferum:
Inheritance: Not applicable; Age of onset: Adolescent,Childhood,Infancy,Neonatal

Classifications:

Orphanet: 54 
Rare skin diseases


External Ids:

Disease Ontology11 DOID:5445
NCIt45 C4172
Orphanet54 ORPHA840
SNOMED-CT62 239121009, 8934006
UMLS via Orphanet69 C0406803
ICD10 via Orphanet31 D23.9

Summaries for Syringocystadenoma Papilliferum

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Wikipedia:71 Syringocystadenoma papilliferum (also known as \"Syringadenoma papilliferum\") is an apocrine tumor. more...

MalaCards based summary: Syringocystadenoma Papilliferum, also known as fistulous vegetative verrucous hydradenoma, is related to syringoma and diencephalic astrocytomas, and has symptoms including abnormal hair quantity, abnormal blistering of the skin and neoplasm of the skin. An important gene associated with Syringocystadenoma Papilliferum is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways are Bladder cancer and Vemurafenib Pathway, Pharmacodynamics. Affiliated tissues include skin and lung, and related mouse phenotypes are Decreased viability and Decreased cell migration.

Related Diseases for Syringocystadenoma Papilliferum

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Diseases related to Syringocystadenoma Papilliferum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1syringoma30.2MUC1, VIM
2diencephalic astrocytomas10.5BRAF, GFAP
3adenoma10.5
4anaplastic oligodendroglioma10.5ACTC1, GFAP
5pterygium colli mental retardation digital anomalies10.5BRAF, KRAS
6rad51c-related fanconi anemia10.5BRAF, KRAS
7apocrine adenoma10.4
8mediastinum teratoma10.4BRAF, KRAS
9fibroma10.4BRAF, KRAS
10xq12-q13.3 duplication syndrome10.4ACTC1, DES
11salcedo syndrome10.4DES, GFAP
12sialolithiasis10.4ACTC1, GFAP
13radioulnar synostosis10.4BRAF, KRAS
14basal cell carcinoma10.4
15small intestinal sarcoma10.4ACTC1, GFAP
16mixed epithelial stromal tumour10.4BRAF, GFAP
17central nervous system sarcoma10.3ACTC1, GFAP
18leukoencephalopathy palmoplantar keratoderma10.3BRAF, KRAS
19placental site trophoblastic tumor10.3ACTC1, MUC1
20hereditary essential tremor 510.3BRAF, KRAS
21pura syndrome10.3ACTC1, DES
22pleuropulmonary blastoma type 210.3ACTC1, DES
23appendix lymphoma10.3KRAS, MUC1
24parovarian cyst10.3ACTC1, DES
25postcricoid region cancer10.3ACTC1, MUC1
26intracystic papillary adenoma10.3GFAP, S100B
27hidradenoma10.3
28hemiplegia alterans10.3GFAP, S100B
29infantile glycine encephalopathy10.3ACTC1, S100B
30tabes dorsalis10.3KRAS, MUC1
31mushroom workers' lung10.3ACTC1, S100B
32diffuse pulmonary fibrosis10.3ACTC1, S100B
33classic pulmonary blastoma10.3DES, KRAS
34migraine with aura10.3KRAS, MUC1
35ovarian serous adenofibroma10.2KRAS, MUC1
36combined thymoma10.2DES, MUC1
37advanced sleep phase syndrome10.2KRAS, MUC1
38iodine hypothyroidism10.2GFAP, S100B
39epilepsy with generalized tonic-clonic seizures10.2KRAS, MUC1
40lateral sinus thrombosis10.2KRAS, MUC1
41white platelet syndrome10.2DES, MUC1
42adult central nervous system primitive neuroectodermal neoplasm10.2DES, GFAP
43radio-ulnar synostosis type 110.2DES, MUC1
44orbit rhabdomyosarcoma10.2ACTC1, DES
45ulcerative colitis10.2GFAP, S100B
46logopenic progressive aphasia10.2MUC1, S100B
47intermediate dend syndrome10.2MUC1, S100B
48relapsing epidemic typhus10.2MUC1, S100B
49pituitary deficiency due to rathke's pouch cysts10.2MUC1, S100B
50bickerstaff brainstem encephalitis10.2DES, S100B

Graphical network of the top 20 diseases related to Syringocystadenoma Papilliferum:



Diseases related to syringocystadenoma papilliferum

Symptoms & Phenotypes for Syringocystadenoma Papilliferum

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Human phenotypes related to Syringocystadenoma Papilliferum:

 64 54 (show all 7)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormal hair quantity64 hallmark (90%) HP:0011362
2 abnormal blistering of the skin64 54 typical (50%) Frequent (79-30%) HP:0008066
3 neoplasm of the skin64 occasional (7.5%) HP:0008069
4 subcutaneous nodule54 Very frequent (99-80%)
5 sparse scalp hair54 Very frequent (99-80%)
6 nevus sebaceous54 Occasional (29-5%)
7 papule54 Very frequent (99-80%)

GenomeRNAi Phenotypes related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00381-A-19.9BRAF, KRAS, MUC1
2GR00055-A-19.2BRAF, KRAS, MUC1, VIM

MGI Mouse Phenotypes related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.4ACTC1, BRAF, DES, GFAP, KRAS, VIM
2MP:00053868.2BRAF, DES, GFAP, KRAS, S100B, VIM
3MP:00053767.6ACTC1, BRAF, DES, GFAP, KRAS, S100B
4MP:00053697.5ACTC1, BRAF, DES, GFAP, KRAS, VIM

Drugs & Therapeutics for Syringocystadenoma Papilliferum

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Syringocystadenoma Papilliferum

Genetic Tests for Syringocystadenoma Papilliferum

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Anatomical Context for Syringocystadenoma Papilliferum

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MalaCards organs/tissues related to Syringocystadenoma Papilliferum:

36
Skin, Lung

Publications for Syringocystadenoma Papilliferum

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Articles related to Syringocystadenoma Papilliferum:

(show top 50)    (show all 147)
idTitleAuthorsYear
1
Tubulopapillary Cystic Adenoma With Apocrine Differentiation: A Unifying Concept for Syringocystadenoma Papilliferum, Apocrine Gland Cyst, and Tubular Papillary Adenoma. (28033156)
2016
2
Syringocystadenoma papilliferum of the external auditory canal. Case report and literature review. (27658577)
2016
3
Syringocystadenoma papilliferum with multiple lung metastases and long survival. (27837643)
2016
4
Syringocystadenoma Papilliferum of the Scalp Arising from a Nevus Sebaceous. (27761094)
2016
5
Cytological diagnosis of syringocystadenoma papilliferum a rare adnexal tumor. (26229253)
2015
6
Fifteen year natural history of lower eyelid syringocystadenoma papilliferum in a young girl. (26097022)
2015
7
Syringocystadenoma papilliferum in an unusual location. (26734876)
2015
8
Activating mutations in the RAS/mitogen-activated protein kinase signaling pathway in sporadic trichoblastoma and syringocystadenoma papilliferum. (25532942)
2015
9
Eruptive Syringocystadenoma Papilliferum, Keratoacanthoma, and Verruca Vulgaris in a Keratinocytic Epidermal Nevus on the Leg. (26790513)
2015
10
Syringocystadenoma papilliferum arising on naevus sebaceus: A 6-year-old child case described with dermoscopic features. (25900640)
2015
11
Trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma, and tumor of the follicular infundibulum with signet-ring cells, all arising in nevus sebaceus. (25761672)
2015
12
Tricholemmoma, sebaceoma, syringocystadenoma papilliferum, basal cell carcinoma, trichilemmal cyst arising within a nevus sebaceous. (26224239)
2015
13
Somatic BRAF c.1799T>A p.V600E Mosaicism syndrome characterized by a linear syringocystadenoma papilliferum, anaplastic astrocytoma, and ocular abnormalities. (26360803)
2015
14
Multiple pigmented trichoblastomas, sebaceous carcinoma and syringocystadenoma papilliferum arising within a nevus sebaceous. (25906325)
2015
15
Syringocystadenoma papilliferum of the male nipple. (26269194)
2015
16
Basal Cell Carcinoma and Syringocystadenoma Papilliferum Arising in Nevus Sebaceous on Face-A Rare Entity. (26677302)
2015
17
Somatic V600E BRAF Mutation in Linear and Sporadic Syringocystadenoma Papilliferum. (25950823)
2015
18
A case of syringocystadenoma papilliferum of eyelid with literature review. (26265653)
2015
19
Linear syringocystadenoma papilliferum on female breast: a rare appendageal tumour on an uncommon location. (25756479)
2014
20
Syringocystadenoma papilliferum developing over hyperkeratosis of the nipple in a pregnant woman. (24629369)
2014
21
Syringocystadenoma papilliferum of the upper lip. (25364565)
2014
22
Syringocystadenoma papilliferum: an unusual presentation. (24995228)
2014
23
Syringocystadenoma papilliferum of the bony external auditory canal: a rare tumor in a rare location. (23762705)
2013
24
A case of syringocystadenoma papilliferum on lower leg: a rare location. (24082194)
2013
25
Follicular hybrid cyst with isthmic-catagen, pilomatrical, and syringocystadenoma papilliferum components. (22699865)
2013
26
Syringocystadenoma papilliferum arising on the scrotum. (22612442)
2013
27
Agminated syringocystadenoma papilliferum: a new clinical presentation of a rare benign adnexal neoplasm. (24021448)
2013
28
Syringocystadenoma papilliferum on the dorsum of the foot. (23621843)
2013
29
Linear syringocystadenoma papilliferum: a case report with review of literature. (24082219)
2013
30
Syringocystadenoma papilliferum of the scalp in an adult male - a case report. (23730665)
2013
31
Syringocystadenoma papilliferum in the right lower abdomen: a case report and review of literature. (23569386)
2013
32
Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands: report of a case and review of the literature. (22262361)
2012
33
Giant linear syringocystadenoma papilliferum of the back. (22199089)
2012
34
Carcino-sarcoma in a case of syringocystadenoma papilliferum: a rare entity. (24765470)
2012
35
Adult-onset linear syringocystadenoma papilliferum over the inguinal fold: a case report with emphasis on mast cell staining pattern. (23217957)
2012
36
Syringocystadenoma papilliferum of the back combined with a tubular apocrine adenoma. (22148038)
2011
37
Linear syringocystadenoma papilliferum: an uncommon event with a favorable prognosis. (21906485)
2011
38
Syringocystadenoma papilliferum: Unusual location. (21696687)
2011
39
Linear syringocystadenoma papilliferum: an unusual location. (21276059)
2011
40
What is your diagnosis? Syringocystadenoma papilliferum. (22017063)
2011
41
Basal cell carcinoma, syringocystadenoma papilliferum, trichilemmoma, and sebaceoma arising within a nevus sebaceus associated with pigmented nevi. (22093024)
2011
42
Lipomatous apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. (21854651)
2011
43
Syringocystadenoma papilliferum on the male nipple. (21914158)
2011
44
Report of 3 histopathologically documented cases of syringocystadenoma papilliferum involving the eyelid. (21784220)
2011
45
Dermoscopic aspects of syringocystadenoma papilliferum associated with nevus sebaceus. (22281917)
2011
46
Syringocystadenoma papilliferum. (22372162)
2011
47
Syringocystadenoma Papilliferum in Co-existence with Tubular Apocrine Adenoma on the Calf. (22148043)
2011
48
Squamous cell carcinoma, syringocystadenoma papilliferum and apocrine adenoma arising in a nevus sebaceus of Jadassohn. (21393932)
2011
49
A Case of Tubular Apocrine Adenoma with Syringocystadenoma Papilliferum that Developed in a Nevus Sebaceus. (20711270)
2010
50
A case of zonal syringocystadenoma papilliferum of the axilla mimicking verruca vulgaris. (20098083)
2010

Variations for Syringocystadenoma Papilliferum

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Expression for genes affiliated with Syringocystadenoma Papilliferum

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Search GEO for disease gene expression data for Syringocystadenoma Papilliferum.

Pathways for genes affiliated with Syringocystadenoma Papilliferum

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GO Terms for genes affiliated with Syringocystadenoma Papilliferum

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Cellular components related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell bodyGO:004429710.2ACTC1, BRAF, GFAP
2intermediate filamentGO:00058829.2DES, GFAP, VIM
3intermediate filament cytoskeletonGO:00451118.8DES, GFAP, VIM
4cytoplasmGO:00057377.0ACTC1, BRAF, DES, GFAP, KRAS, MUC1

Biological processes related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1astrocyte developmentGO:00140029.9GFAP, VIM
2Bergmann glial cell differentiationGO:00600209.9GFAP, VIM
3intermediate filament-based processGO:00451039.9GFAP, VIM
4negative regulation of neuron projection developmentGO:00109779.9GFAP, VIM
5long-term synaptic potentiationGO:00602919.8BRAF, GFAP, S100B
6visual learningGO:00085429.7BRAF, KRAS
7intermediate filament organizationGO:00451099.4DES, GFAP, VIM
8muscle filament slidingGO:00300499.4ACTC1, DES, VIM
9positive regulation of gene expressionGO:00106288.9ACTC1, BRAF, KRAS, VIM

Molecular functions related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052008.8DES, GFAP, VIM
2identical protein bindingGO:00428028.7BRAF, DES, S100B, VIM

Sources for Syringocystadenoma Papilliferum

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet