MCID: SYR002
MIFTS: 41

Syringocystadenoma Papilliferum malady

Rare diseases, Skin diseases, Cancer diseases categories

Aliases & Classifications for Syringocystadenoma Papilliferum

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 61UMLS, 39NCIt, 56SNOMED-CT, 26ICD10 via Orphanet, 62UMLS via Orphanet
See all sources

Aliases & Descriptions for Syringocystadenoma Papilliferum:

Name: Syringocystadenoma Papilliferum 8 42 10 48 61
Fistulous Vegetative Verrucous Hydradenoma 42 48
 
Papillary Syringadenoma 8


Classifications:



Characteristics (Orphanet epidemiological data):

48
syringocystadenoma papilliferum:
Inheritance: Not applicable; Age of onset: Childhood


External Ids:

Disease Ontology8 DOID:5445
NCIt39 C4172
Orphanet48 840
SNOMED-CT56 239121009, 8934006
ICD10 via Orphanet26 D23.9
UMLS via Orphanet62 C0406803

Summaries for Syringocystadenoma Papilliferum

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Wikipedia:64 Syringocystadenoma papilliferum (also known as \"Syringadenoma papilliferum\") is an apocrine tumor. more...

MalaCards based summary: Syringocystadenoma Papilliferum, also known as fistulous vegetative verrucous hydradenoma, is related to hidradenoma and syringoma, and has symptoms including abnormal hair quantity, abnormal blistering of the skin and neoplasm of the skin. An important gene associated with Syringocystadenoma Papilliferum is PTCH1 (patched 1), and among its related pathways is Striated Muscle Contraction. The compounds 2-methoxyethanol and actomyosin have been mentioned in the context of this disorder. Affiliated tissues include skin and breast.

Related Diseases for Syringocystadenoma Papilliferum

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Diseases related to Syringocystadenoma Papilliferum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1hidradenoma31.1MUC1, CLEC2A, PIP
2syringoma31.0MUC1, S100B
3basal cell carcinoma31.0KRT15, ACTC1, PTCH1, PIP
4leiomyosarcoma29.9VIM, MUC1, ACTC1, S100B
5sarcoma29.9VIM, MUC1, ACTC1, S100B
6melanoma29.7PTCH1, VIM, ACTC1, PCNA, S100B
7adenoma10.8
8apocrine adenoma10.8
9acanthoma10.5CLEC2A
10hidrocystoma10.4
11histiocytosis10.4S100B
12ganglioglioma10.4S100B
13hemangioma10.4ACTC1
14cystadenocarcinoma10.4MUC1
15spiradenoma10.3CLEC2A, KRT15
16focal dermal hypoplasia10.3
17pick disease10.3
18niemann-pick disease10.3
19cystadenoma10.3
20sebaceous adenoma10.3
21cutaneous leiomyosarcoma10.3
22adenoiditis10.3
23sweat gland carcinoma10.3
24verrucous carcinoma10.3
25adenosquamous carcinoma10.3
26embryonal rhabdomyosarcoma10.3PTCH1, ACTC1
27adenomatoid tumor10.3VIM
28alopecia10.2CLEC2A, KRT15
29papilloma10.2ACTC1, PCNA
30cutaneous fibrous histiocytoma10.2ACTC1, S100B
31paget disease, extramammary10.2PIP, MUC1
32ameloblastoma10.2PCNA, PTCH1
33breast fibroadenoma10.2KRT15, PCNA
34tubular adenocarcinoma10.2ACTC1, MUC1
35fibrous meningioma10.1S100B, MUC1
36choroid plexus papilloma10.1MUC1, S100B
37anaplastic ependymoma10.1MUC1, S100B
38glomus tumor10.1VIM, ACTC1
39bladder cancer, somatic10.1ACTC1, PTCH1
40microphthalmia10.1ACTC1, S100B
41epithelioid leiomyosarcoma10.1VIM, ACTC1
42hemangioblastoma10.1MUC1, S100B
43pseudosarcomatous fibromatosis10.1VIM, ACTC1
44endometrial stromal sarcoma10.1ACTC1, VIM
45neuroendocrine tumor10.1MUC1, S100B
46angiomyolipoma10.1ACTC1, VIM
47fibromatosis10.1ACTC1, VIM
48medulloblastoma10.1S100B, ACTC1, PTCH1
49granular cell tumor10.0VIM, S100B
50clear cell ependymoma10.0VIM, MUC1

Graphical network of the top 20 diseases related to Syringocystadenoma Papilliferum:



Diseases related to syringocystadenoma papilliferum

Symptoms for Syringocystadenoma Papilliferum

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Symptoms:

 48
  • follicular/erythematous/edematous papules/milium
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • capillary hemangioma/nevus/naevus flammeus/port-wine stain
  • skin/cutaneous neoplasm/tumor/carcinoma/cancer (excluding melanoma)

HPO human phenotypes related to Syringocystadenoma Papilliferum:

id Description Frequency HPO Source Accession
1 abnormal hair quantity hallmark (90%) HP:0011362
2 abnormal blistering of the skin typical (50%) HP:0008066
3 neoplasm of the skin occasional (7.5%) HP:0008069

Drugs & Therapeutics for Syringocystadenoma Papilliferum

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Drug clinical trials:

Search ClinicalTrials for Syringocystadenoma Papilliferum

Search NIH Clinical Center for Syringocystadenoma Papilliferum

Genetic Tests for Syringocystadenoma Papilliferum

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Anatomical Context for Syringocystadenoma Papilliferum

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MalaCards organs/tissues related to Syringocystadenoma Papilliferum:

31
Skin, Breast

Animal Models for Syringocystadenoma Papilliferum or affiliated genes

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Publications for Syringocystadenoma Papilliferum

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Articles related to Syringocystadenoma Papilliferum:

(show top 50)    (show all 132)
idTitleAuthorsYear
1
Activating mutations in the RAS/mitogen-activated protein kinase signaling pathway in sporadic trichoblastoma and syringocystadenoma papilliferum. (25532942)
2015
2
Linear syringocystadenoma papilliferum on female breast: a rare appendageal tumour on an uncommon location. (25756479)
2014
3
Syringocystadenoma papilliferum developing over hyperkeratosis of the nipple in a pregnant woman. (24629369)
2014
4
Syringocystadenoma papilliferum: an unusual presentation. (24995228)
2014
5
Syringocystadenoma papilliferum arising on the scrotum. (22612442)
2013
6
Syringocystadenoma papilliferum of the bony external auditory canal: a rare tumor in a rare location. (23762705)
2013
7
Agminated syringocystadenoma papilliferum: a new clinical presentation of a rare benign adnexal neoplasm. (24021448)
2013
8
A case of syringocystadenoma papilliferum on lower leg: a rare location. (24082194)
2013
9
Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands: report of a case and review of the literature. (22262361)
2012
10
Adult-onset linear syringocystadenoma papilliferum over the inguinal fold: a case report with emphasis on mast cell staining pattern. (23217957)
2012
11
Basal cell carcinoma, syringocystadenoma papilliferum, trichilemmoma, and sebaceoma arising within a nevus sebaceus associated with pigmented nevi. (22093024)
2011
12
Syringocystadenoma papilliferum of the back combined with a tubular apocrine adenoma. (22148038)
2011
13
Linear syringocystadenoma papilliferum: an uncommon event with a favorable prognosis. (21906485)
2011
14
Lipomatous apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. (21854651)
2011
15
Syringocystadenoma papilliferum on the male nipple. (21914158)
2011
16
Syringocystadenoma papilliferum: Unusual location. (21696687)
2011
17
A case of zonal syringocystadenoma papilliferum of the axilla mimicking verruca vulgaris. (20098083)
2010
18
Syringocystadenoma papilliferum: an unusual presentation. (20199464)
2009
19
Syringocystadenoma papilliferum-like lesion of the vulva. (18752136)
2008
20
Ductal carcinoma arising from syringocystadenoma papilliferum in the external auditory canal. (17159662)
2007
21
Linear syringocystadenoma papilliferum of the scalp. (17243981)
2007
22
Trichoblastoma and syringocystadenoma papilliferum arising in naevus sebaceous in a 4-year-old boy. (17342802)
2007
23
Syringocystadenoma papilliferum associated with apocrine poroma. (16674787)
2006
24
Basal cell carcinoma and syringocystadenoma papilliferum arising in nevus sebaceus. (16404295)
2006
25
Syringocystadenoma papilliferum: report of 8 cases. (17036946)
2006
26
Syringocystadenoma papilliferum of the eyelid in a young girl. (16418676)
2006
27
A 64-year-old woman with vulvar papule. Vulvar syringocystadenoma papilliferum. (15859658)
2005
28
Tubular apocrine adenoma in association with syringocystadenoma papilliferum. (12639465)
2003
29
Syringocystadenoma papilliferum arising on the scrotum. (12822557)
2003
30
Syringocystadenoma papilliferum mimicking basal cell carcinoma on the lower eyelid: a case report. (12661924)
2002
31
Trichilemmoma and syringocystadenoma papilliferum arising in naevus sebaceous. (12009106)
2002
32
Linear warty papules on the neck of a young woman: syringocystadenoma papilliferum (SP) in a sebaceous nevus (SN). (12164752)
2002
33
Syringocystadenoma papilliferum: a study of potential tumor suppressor genes. (11285401)
2001
34
Mixed syringocystadenoma papilliferum and papillary eccrine adenoma occurring in a scrotal condyloma. (10774942)
2000
35
Syringocystadenoma papilliferum presenting as a cutaneous horn. (10848760)
2000
36
Syringocystadenoma papilliferum mimicking breast carcinoma. (10698227)
2000
37
Multiple linear syringocystadenoma papilliferum. (10188162)
1999
38
A case of ductal sweat gland carcinoma connected to syringocystadenoma papilliferum arising in nevus sebaceus. (7699123)
1994
39
Condyloma acuminatum associated with syringocystadenoma papilliferum. (7864300)
1994
40
Fine needle aspiration cytology of chondroid syringoma and syringocystadenoma papilliferum. A report of two cases. (8392255)
1993
41
Syringocystadenoma papilliferum: report of an unusual case. (1661713)
1991
42
A case of tubular apocrine adenoma with syringocystadenoma papilliferum. (2551940)
1989
43
Nevus sebaceus, syringocystadenoma papilliferum, and basal cell epithelioma. (2995466)
1985
44
Syringocystadenoma papilliferum. A plasmacytotropic tumor. (2996375)
1985
45
Pathology quiz case 2: syringocystadenoma papilliferum. (6279032)
1982
46
Syringocystadenoma papilliferum of the eyelid. (6275322)
1981
47
Syringocystadenoma papilliferum in an unusual location. Report of a case. (182084)
1976
48
Syringocystadenoma papilliferum: light and electron microscopic studies. (78616)
1976
49
A mixed tumor occurring as a syringocystadenoma papilliferum with a nevus sebaceus; report of a case. (13486945)
1958
50
Syringocystadenoma papilliferum, nevus sebaceus and basal-cell epithelioma (with features of epithelioma adenoides cysticum and syringoma); their concurrent presence in a single tumor; report of a case. (14901605)
1951

Variations for Syringocystadenoma Papilliferum

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Expression for genes affiliated with Syringocystadenoma Papilliferum

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Search GEO for disease gene expression data for Syringocystadenoma Papilliferum.

Pathways for genes affiliated with Syringocystadenoma Papilliferum

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Pathways related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7ACTC1, VIM

Compounds for genes affiliated with Syringocystadenoma Papilliferum

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Compounds related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

(show all 46)
idCompoundScoreTop Affiliating Genes
12-methoxyethanol4410.0VIM, ACTC1
2actomyosin449.9VIM, ACTC1
3temozolomide44 1110.8VIM, PCNA
43-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.8PCNA, S100B
5orcein449.7VIM, S100B, ACTC1
6roscovitine449.7VIM, PCNA
74-hydroxytamoxifen449.6VIM, S100B
8matrigel449.6VIM, ACTC1, MUC1
9chloramphenicol44 1 50 1112.6S100B, MUC1, VIM
10calcipotriol44 60 28 1112.5KRT15, VIM
11procollagen449.5PCNA, ACTC1, VIM
12bromodeoxyuridine449.5VIM, PCNA, S100B
13cytarabine44 50 1111.5MUC1, PCNA, VIM
14forskolin44 50 1111.4VIM, S100B, MUC1
15methotrexate50 44 1111.4VIM, MUC1, PCNA
16etoposide44 50 60 1112.4PCNA, S100B, VIM
17paclitaxel44 50 1111.4PCNA, VIM, S100B
18cyclosporin a44 28 6011.4ACTC1, S100B, PCNA
19butyrate449.4PCNA, MUC1, VIM
20iron44 2410.4ACTC1, S100B, VIM
21hydroxyapatite449.3S100B, VIM
22dihydrotestosterone44 28 24 1112.3PIP, VIM, MUC1
23s 100449.3VIM, S100B, ACTC1, MUC1
24glycogen44 2410.3VIM, MUC1, ACTC1, S100B
25glutamine449.2VIM, S100B, PCNA
26biotin44 24 1111.2MUC1, VIM, ACTC1, PCNA
27eosin449.1VIM, MUC1, PCNA, S100B
28lactate449.1VIM, PCNA, S100B
29thymidine44 2410.1MUC1, PCNA, S100B
30cysteine449.0MUC1, S100B, PCNA, VIM
31tamoxifen44 50 28 1111.9VIM, PIP, PCNA, MUC1
32estradiol44 24 1110.8PIP, VIM, PCNA, MUC1
33reticulin448.8ACTC1, VIM, PCNA, S100B, MUC1
34hematoxylin448.8S100B, PCNA, MUC1, VIM, ACTC1
35formaldehyde44 249.8ACTC1, MUC1, PCNA, VIM, S100B
36creatinine448.8ACTC1, VIM, MUC1, S100B, PCNA
37dexamethasone44 50 28 1111.8VIM, ACTC1, MUC1, S100B, PCNA
38vegf448.8ACTC1, S100B, PCNA, VIM, MUC1
39mucicarmine448.7VIM, MUC1, S100B, ACTC1, PIP
40tyrosine448.5PTCH1, ACTC1, S100B, KRT15, MUC1
41b 723448.2PCNA, S100B, MUC1, VIM, PIP, ACTC1
42progesterone44 28 60 24 1112.2PIP, VIM, MUC1, ACTC1, S100B, PCNA
43testosterone44 60 24 1111.2ACTC1, VIM, PIP, PCNA, S100B, MUC1
44estrogen448.2PIP, PCNA, ACTC1, S100B, VIM, MUC1
45retinoic acid44 248.9VIM, PCNA, ACTC1, MUC1, S100B, KRT15
46paraffin447.9S100B, ACTC1, MUC1, VIM, PTCH1, PIP

GO Terms for genes affiliated with Syringocystadenoma Papilliferum

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Cellular components related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:00700627.3KRT15, PCNA, ACTC1, MUC1, VIM, PIP

Biological processes related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.7ACTC1, VIM

Molecular functions related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:00019489.4VIM, PIP
2scaffold protein bindingGO:00971109.1KRT15, VIM
3protein bindingGO:00055156.7PTCH1, CLEC2A, VIM, MUC1, PCNA, S100B

Sources for Syringocystadenoma Papilliferum

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet