MCID: SYR002
MIFTS: 45

Syringocystadenoma Papilliferum malady

Skin diseases, Cancer diseases categories

Summaries for Syringocystadenoma Papilliferum

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63Wikipedia, 32MalaCards
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Wikipedia:63 Syringocystadenoma papilliferum (also known as \"Syringadenoma papilliferum\") is an apocrine tumor. more...

MalaCards: Syringocystadenoma Papilliferum, also known as fistulous vegetative verrucous hydradenoma, is related to adenoma and basal cell carcinoma, and has symptoms including follicular/erythematous/edematous papules/milium, subcutaneous nodules/lipomas/tumefaction/swelling and hypotrichosis/atrichia/atrichiasis/scalp hairlessness. An important gene associated with Syringocystadenoma Papilliferum is ACTC1 (actin, alpha, cardiac muscle 1). The compounds 2-methoxyethanol and orcein have been mentioned in the context of this disorder. Affiliated tissues include skin and breast.

Aliases & Classifications for Syringocystadenoma Papilliferum

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 39NCIt, 56SNOMED-CT, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Characteristics (Orphanet epidemiological data):

48
syringocystadenoma papilliferum:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

syringocystadenoma papilliferum 8 42 10 48 60
fistulous vegetative verrucous hydradenoma 42 48
papillary syringadenoma 8


External Ids:

Disease Ontology8 DOID:5445
NCIt39 C4172
ICD10 via Orphanet26 D23.9
SNOMED-CT56 239121009, 8934006
SNOMED-CT via Orphanet57 239121009
UMLS via Orphanet61 C0406803

Related Diseases for Syringocystadenoma Papilliferum

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17GeneCards, 18GeneDecks
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Diseases related to Syringocystadenoma Papilliferum via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.1ACTC1, PCNA, MUC1
2basal cell carcinoma30.9PTCH1, ACTC1, KRT15, PIP
3hidradenoma30.8PIP, MUC1, CLEC2A
4syringoma30.6MUC1, S100B
5hidrocystoma30.5PIP, SGTA
6mucoepidermoid carcinoma30.3ACTC1, PCNA, MUC1
7leiomyosarcoma30.3VIM, S100B, MUC1, ACTC1
8melanoma30.2VIM, S100B, PCNA, ACTC1, PTCH1
9squamous cell carcinoma30.2VIM, PIP, MUC1, PCNA, KRT15, ACTC1
10apocrine adenoma10.7
11niemann-pick disease10.2
12sebaceous adenoma10.2
13cystadenoma10.2
14sweat gland carcinoma10.2
15focal dermal hypoplasia10.2
16follicular infundibulum tumor10.2
17eccrine papillary adenoma10.2
18breast apocrine adenoma10.2
19pigmented basal cell carcinoma10.2
20sebaceous basal cell carcinoma10.2
21cutaneous leiomyosarcoma10.2
22verrucous carcinoma10.2
23adenosquamous carcinoma10.2
24papillary adenoma10.2
25adenoiditis10.2
26breast adenoma10.2
27follicular adenoma10.2
28fasciitis10.0ACTC1
29li-fraumeni syndrome10.0PIP
30psoriasis10.0KRT15
31acanthoma10.0CLEC2A
32familial adenomatous polyposis10.0PTCH1
33thyroid cancer10.0PTCH1
34paraganglioma10.0S100B
35teratoma10.0ACTC1
36keratosis10.0CLEC2A
37hemangioma10.0ACTC1
38endometriosis10.0ACTC1
39histiocytosis10.0S100B
40benign meningioma10.0PCNA
41endometrial carcinoma10.0PCNA
42spiradenoma10.0KRT15, CLEC2A
43cystadenocarcinoma10.0MUC1
44pituitary adenoma10.0PCNA
45alopecia10.0CLEC2A, KRT15
46nevoid basal cell carcinoma syndrome10.0PTCH1
47oligodendroglioma10.0PCNA
48lymphangioma10.0ACTC1
49laryngeal benign neoplasm10.0PCNA
50desmoid tumor10.0ACTC1

Graphical network of the top 20 diseases related to Syringocystadenoma Papilliferum:



Diseases related to syringocystadenoma papilliferum

Clinical Features for Syringocystadenoma Papilliferum

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Sources:
48Orphanet
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Symptoms:

48
  • follicular/erythematous/edematous papules/milium
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • capillary hemangioma/nevus/naevus flammeus/port-wine stain
  • skin/cutaneous neoplasm/tumor/carcinoma/cancer (excluding melanoma)

Drugs & Therapeutics for Syringocystadenoma Papilliferum

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Syringocystadenoma Papilliferum

Drug clinical trials:

Search ClinicalTrials for Syringocystadenoma Papilliferum

Search NIH Clinical Center for Syringocystadenoma Papilliferum

Search CenterWatch for Syringocystadenoma Papilliferum

Genetic Tests for Syringocystadenoma Papilliferum

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Anatomical Context for Syringocystadenoma Papilliferum

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32MalaCards
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MalaCards organs/tissues related to Syringocystadenoma Papilliferum:

32
Skin, Breast

Animal Models for Syringocystadenoma Papilliferum or affiliated genes

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Publications for Syringocystadenoma Papilliferum

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50PubMed
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Articles related to Syringocystadenoma Papilliferum:

(show top 50)    (show all 124)
idTitleAuthorsYear
1
Syringocystadenoma papilliferum arising on the scrotum. (22612442)
2013
2
Syringocystadenoma papilliferum of the bony external auditory canal: a rare tumor in a rare location. (23762705)
2013
3
Agminated syringocystadenoma papilliferum: a new clinical presentation of a rare benign adnexal neoplasm. (24021448)
2013
4
Follicular hybrid cyst with isthmic-catagen, pilomatrical, and syringocystadenoma papilliferum components. (22699865)
2013
5
Syringocystadenoma papilliferum in the right lower abdomen: a case report and review of literature. (23569386)
2013
6
Giant linear syringocystadenoma papilliferum of the back. (22199089)
2012
7
Syringocystadenoma papilliferum of the back combined with a tubular apocrine adenoma. (22148038)
2011
8
A Case of Tubular Apocrine Adenoma with Syringocystadenoma Papilliferum that Developed in a Nevus Sebaceus. (20711270)
2010
9
Syringocystadenoma papilliferum: an unusual presentation. (20199464)
2009
10
Unique case: syringocystadenoma papilliferum associated with an eccrine nevus. (19730225)
2009
11
Syringocystadenoma papilliferum in a patient with focal dermal hypoplasia due to a novel PORCN mutation. (19221286)
2009
12
Niemann-Pick disease in association with syringocystadenoma papilliferum. (20199469)
2009
13
Syringocystadenoma papilliferum on the thigh: an unusual location. (19293506)
2009
14
Giant condyloma acuminata with syringocystadenoma papilliferum. (19439910)
2009
15
Linear papules and nodules on the neck. Syringocystadenoma papilliferum (SP). (19015430)
2008
16
Ductal carcinoma arising from syringocystadenoma papilliferum in the external auditory canal. (17159662)
2007
17
Linear syringocystadenoma papilliferum of the scalp. (17243981)
2007
18
Sweat gland hamartoma resembling human syringocystadenoma papilliferum in two young cats. (17991164)
2007
19
An unusual complex cutaneous adnexal tumor composed of syringocystadenoma papilliferum, apocrine hidrocystoma, and clear cell syringoma. (17598859)
2007
20
Naevus sebaceus on the female breast accompanied with a tubular apocrine adenoma and a syringocystadenoma papilliferum. (17535243)
2007
21
Basal cell carcinoma and syringocystadenoma papilliferum arising in nevus sebaceus. (16404295)
2006
22
Syringocystadenoma papilliferum of the eyelid in a young girl. (16418676)
2006
23
Syringocystadenoma papilliferum: report of first case on the pinna. (17105677)
2006
24
Giant naevoid syringocystadenoma papilliferum. (16159744)
2005
25
Keratinizing squamous epithelium associated with Syringocystadenoma papilliferum differentiates towards infrainfundibulum: case report with immunohistochemical study of cytokeratins. (16222893)
2005
26
Syringocystadenoma papilliferum: an unusual cutaneous lesion in a pediatric patient. (15238924)
2004
27
Tubular apocrine adenoma in association with syringocystadenoma papilliferum. (12639465)
2003
28
Syringocystadenoma papilliferum arising on the scrotum. (12822557)
2003
29
Multiple pigmented trichoblastomas and syringocystadenoma papilliferum in naevus sebaceous mimicking a malignant melanoma: a clinical dermoscopic-pathological case study. (14632818)
2003
30
Linear warty papules on the neck of a young woman: syringocystadenoma papilliferum (SP) in a sebaceous nevus (SN). (12164752)
2002
31
An immunohistochemical and ultrastructural study of syringocystadenoma papilliferum. (12410704)
2002
32
Nevus comedonicus with hidradenoma papilliferum and syringocystadenoma papilliferum in the female genital area. (12530358)
2002
33
A case of syringocystadenoma papilliferum: an unusal localization on postoperative scar. (12428858)
2002
34
Linear syringocystadenoma papilliferum of the thigh. (11423852)
2001
35
Mixed syringocystadenoma papilliferum and papillary eccrine adenoma occurring in a scrotal condyloma. (10774942)
2000
36
Multiple linear syringocystadenoma papilliferum. (10188162)
1999
37
An unusual case of syringocystadenoma papilliferum of the eyelid. (9018997)
1996
38
Condyloma acuminatum associated with syringocystadenoma papilliferum. (7864300)
1994
39
Syringocystadenoma papilliferum mimicking basal cell carcinoma. (8277013)
1994
40
Syringocystadenoma papilliferum of the eyelid. (7977619)
1994
41
Syringocystadenoma papilliferum: report of an unusual case. (1661713)
1991
42
Syringocystadenoma papilliferum. (1661711)
1991
43
A case of tubular apocrine adenoma with syringocystadenoma papilliferum. (2551940)
1989
44
Syringocystadenoma papilliferum developed from giant comedo: a case report. (3027923)
1986
45
Syringocystadenoma papilliferum of the eyelid. (6275322)
1981
46
Syringocystadenoma papilliferum: light and electron microscopic studies. (78616)
1976
47
Nevus sebaceous and syringocystadenoma papilliferum. (183608)
1976
48
Syringocystadenoma papilliferum. An electron microscopic study. (4345083)
1972
49
Nevus sebaceus of Jadassohn with associated syringocystadenoma papilliferum. (4375514)
1971
50
Syringocystadenoma papilliferum, nevus sebaceus and basal-cell epithelioma (with features of epithelioma adenoides cysticum and syringoma); their concurrent presence in a single tumor; report of a case. (14901605)
1951

Genetic Variations for Syringocystadenoma Papilliferum

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Expression for genes affiliated with Syringocystadenoma Papilliferum

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Syringocystadenoma Papilliferum

Search GEO for disease gene expression data for Syringocystadenoma Papilliferum.

Pathways for genes affiliated with Syringocystadenoma Papilliferum

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Compounds for genes affiliated with Syringocystadenoma Papilliferum

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Syringocystadenoma Papilliferum according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
12-methoxyethanol4410.0VIM, ACTC1
2orcein449.8VIM, S100B, ACTC1
3calcipotriol44 59 28 1112.5KRT15, VIM
4procollagen449.5ACTC1, PCNA, VIM
5s 100449.5ACTC1, MUC1, S100B, VIM
6temozolomide44 1110.4VIM, PCNA
7cytarabine44 49 1111.4PCNA, MUC1, VIM
8chloramphenicol44 2 1111.4MUC1, S100B, VIM
9bromodeoxyuridine449.3VIM, S100B, PCNA
10glycogen44 2410.3ACTC1, MUC1, S100B, VIM
11eosin449.2VIM, S100B, MUC1, PCNA
12biotin44 11 2411.2ACTC1, PCNA, MUC1, VIM
13dihydrotestosterone44 28 11 2412.1MUC1, PIP, VIM
14reticulin448.9VIM, S100B, MUC1, PCNA, ACTC1
15hematoxylin448.9VIM, S100B, MUC1, PCNA, ACTC1
16formaldehyde44 249.9ACTC1, PCNA, MUC1, S100B, VIM
17creatinine448.9VIM, S100B, MUC1, PCNA, ACTC1
18methotrexate44 49 1110.9PCNA, MUC1, VIM
19dexamethasone44 49 28 1111.8VIM, S100B, MUC1, PCNA, ACTC1
20mucicarmine448.8ACTC1, MUC1, PIP, S100B, VIM
21tamoxifen44 49 28 1111.8PCNA, MUC1, PIP, VIM
22vegf448.8VIM, S100B, MUC1, PCNA, ACTC1
23estradiol44 11 2410.8VIM, PIP, MUC1, PCNA
24retinoic acid44 249.3VIM, S100B, MUC1, PCNA, KRT15, ACTC1
25b 723448.3ACTC1, PCNA, MUC1, PIP, S100B, VIM
26progesterone44 59 28 11 2412.3VIM, S100B, PIP, MUC1, PCNA, ACTC1
27cysteine448.2SGTA, PCNA, MUC1, S100B, VIM
28paraffin448.0VIM, S100B, PIP, MUC1, PCNA, ACTC1
29testosterone44 59 11 2410.9VIM, S100B, SCAP, PIP, MUC1, PCNA

GO Terms for genes affiliated with Syringocystadenoma Papilliferum

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16Gene Ontology
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Molecular functions related to Syringocystadenoma Papilliferum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.5KRT15, VIM
2protein bindingGO:0055156.1PTCH1, VIM, S100B, SCAP, MUC1, PCNA

Products for genes affiliated with Syringocystadenoma Papilliferum

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Sources for Syringocystadenoma Papilliferum

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet