MCID: SYR002
MIFTS: 43

Syringocystadenoma Papilliferum malady

Categories: Rare diseases, Skin diseases, Cancer diseases

Aliases & Classifications for Syringocystadenoma Papilliferum

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Sources:
11Disease Ontology, 46NIH Rare Diseases, 13DISEASES, 52Orphanet, 66UMLS, 43NCIt, 29ICD10 via Orphanet, 67UMLS via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Syringocystadenoma Papilliferum:

Name: Syringocystadenoma Papilliferum 11 46 13 52 66
Fistulous Vegetative Verrucous Hydradenoma 46 52
Naevus Syringocystadenomatosus Papilliferus 52
Syringadenoma Papilliferum 52
 
Papillary Syringadenoma 11
Papillary Hidradenoma 66
Scap 52

Characteristics:

Orphanet epidemiological data:

52
syringocystadenoma papilliferum:
Inheritance: Not applicable; Age of onset: Adolescent,Childhood,Infancy,Neonatal

Classifications:

Orphanet: 52 
Rare skin diseases


External Ids:

Disease Ontology11 DOID:5445
NCIt43 C4172
Orphanet52 ORPHA840
SNOMED-CT60 239121009, 8934006
ICD10 via Orphanet29 D23.9
UMLS via Orphanet67 C0406803

Summaries for Syringocystadenoma Papilliferum

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Wikipedia:69 Syringocystadenoma papilliferum (also known as \"Syringadenoma papilliferum\") is an apocrine tumor. more...

MalaCards based summary: Syringocystadenoma Papilliferum, also known as fistulous vegetative verrucous hydradenoma, is related to adenoma and apocrine adenoma, and has symptoms including abnormal hair quantity, abnormal blistering of the skin and neoplasm of the skin. An important gene associated with Syringocystadenoma Papilliferum is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways are Bladder cancer and Vemurafenib Pathway, Pharmacodynamics. Affiliated tissues include skin and breast, and related mouse phenotypes are normal and cellular.

Related Diseases for Syringocystadenoma Papilliferum

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Diseases related to Syringocystadenoma Papilliferum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma10.6
2apocrine adenoma10.6
3pterygium colli mental retardation digital anomalies10.5BRAF, KRAS
4rad51c-related fanconi anemia10.5BRAF, KRAS
5basal cell carcinoma10.5
6mediastinum teratoma10.5BRAF, KRAS
7fibroma10.5BRAF, KRAS
8radioulnar synostosis10.4BRAF, KRAS
9diencephalic astrocytomas10.4BRAF, GFAP
10hidradenoma10.4
11leukoencephalopathy palmoplantar keratoderma10.4BRAF, KRAS
12hereditary essential tremor 510.4BRAF, KRAS
13salcedo syndrome10.4DES, GFAP
14anaplastic oligodendroglioma10.4ACTC1, GFAP
15classic pulmonary blastoma10.4DES, KRAS
16xq12-q13.3 duplication syndrome10.3ACTC1, DES
17breast papillary carcinoma10.3KRAS, S100B
18syringoma10.3
19intravascular fasciitis10.3ACTC1, DES
20mixed epithelial stromal tumour10.3BRAF, GFAP
21lyme disease - neurological complications10.3GFAP, S100B
22pura syndrome10.2ACTC1, DES
23pleuropulmonary blastoma type 210.2ACTC1, DES
24pseudoglandular variant testicular seminoma10.2GFAP, S100B
25sialolithiasis10.2ACTC1, GFAP
26external ear disease10.2GFAP, S100B
27intracystic papillary adenoma10.2GFAP, S100B
28hemiplegia alterans10.2GFAP, S100B
29small intestinal sarcoma10.2ACTC1, GFAP
30hidrocystoma10.2
31parovarian cyst10.2ACTC1, DES
32infantile glycine encephalopathy10.2ACTC1, S100B
33mushroom workers' lung10.2ACTC1, S100B
34diffuse pulmonary fibrosis10.2ACTC1, S100B
35cerebrovascular disease10.2DES, S100B
36central nervous system sarcoma10.2ACTC1, GFAP
37iodine hypothyroidism10.2GFAP, S100B
38bickerstaff brainstem encephalitis10.2DES, S100B
392q33.1 microdeletion syndrome10.2BRAF, VIM
40adult central nervous system primitive neuroectodermal neoplasm10.2DES, GFAP
41leopard syndrome 110.1BRAF, KRAS
42ulcerative colitis10.1GFAP, S100B
43orbit rhabdomyosarcoma10.1ACTC1, DES
44pilocytic astrocytoma of cerebellum10.1BRAF, GFAP, KRAS
45adenofibroma10.1KRAS, VIM
46arteritic anterior ischemic optic neuropathy10.1BRAF, KRAS
47localized epiphyseal dysplasia10.1ACTC1, BRAF, KRAS
48pick disease10.1
49focal dermal hypoplasia10.1
50niemann-pick disease10.1

Graphical network of the top 20 diseases related to Syringocystadenoma Papilliferum:



Diseases related to syringocystadenoma papilliferum

Symptoms for Syringocystadenoma Papilliferum

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Symptoms:

 52
  • subcutaneous nodule
  • sparse scalp hair
  • abnormal blistering of the skin
  • nevus sebaceous
  • papule

HPO human phenotypes related to Syringocystadenoma Papilliferum:

id Description Frequency HPO Source Accession
1 abnormal hair quantity hallmark (90%) HP:0011362
2 abnormal blistering of the skin typical (50%) HP:0008066
3 neoplasm of the skin occasional (7.5%) HP:0008069

Drugs & Therapeutics for Syringocystadenoma Papilliferum

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Syringocystadenoma Papilliferum

Genetic Tests for Syringocystadenoma Papilliferum

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Anatomical Context for Syringocystadenoma Papilliferum

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MalaCards organs/tissues related to Syringocystadenoma Papilliferum:

34
Skin, Breast

Animal Models for Syringocystadenoma Papilliferum or affiliated genes

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MGI Mouse Phenotypes related to Syringocystadenoma Papilliferum:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.1ACTC1, BRAF, GFAP, KRAS, S100B
2MP:00053847.7ACTC1, BRAF, DES, GFAP, KRAS, VIM
3MP:00053697.6ACTC1, BRAF, DES, GFAP, KRAS, VIM
4MP:00053857.3ACTC1, BRAF, DES, GFAP, KRAS, VIM
5MP:00053867.0BRAF, DES, GFAP, KRAS, S100B, VIM
6MP:00053766.7ACTC1, BRAF, DES, GFAP, KRAS, S100B

Publications for Syringocystadenoma Papilliferum

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Articles related to Syringocystadenoma Papilliferum:

(show top 50)    (show all 144)
idTitleAuthorsYear
1
Syringocystadenoma papilliferum of the external auditory canal. Case report and literature review. (27658577)
2016
2
Cytological diagnosis of syringocystadenoma papilliferum a rare adnexal tumor. (26229253)
2015
3
Fifteen year natural history of lower eyelid syringocystadenoma papilliferum in a young girl. (26097022)
2015
4
Syringocystadenoma papilliferum in an unusual location. (26734876)
2015
5
Activating mutations in the RAS/mitogen-activated protein kinase signaling pathway in sporadic trichoblastoma and syringocystadenoma papilliferum. (25532942)
2015
6
Eruptive Syringocystadenoma Papilliferum, Keratoacanthoma, and Verruca Vulgaris in a Keratinocytic Epidermal Nevus on the Leg. (26790513)
2015
7
Syringocystadenoma papilliferum arising on naevus sebaceus: A 6-year-old child case described with dermoscopic features. (25900640)
2015
8
Linear syringocystadenoma papilliferum on female breast: a rare appendageal tumour on an uncommon location. (25756479)
2014
9
Syringocystadenoma papilliferum developing over hyperkeratosis of the nipple in a pregnant woman. (24629369)
2014
10
Syringocystadenoma papilliferum of the bony external auditory canal: a rare tumor in a rare location. (23762705)
2013
11
A case of syringocystadenoma papilliferum on lower leg: a rare location. (24082194)
2013
12
Follicular hybrid cyst with isthmic-catagen, pilomatrical, and syringocystadenoma papilliferum components. (22699865)
2013
13
Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands: report of a case and review of the literature. (22262361)
2012
14
Syringocystadenoma papilliferum of the back combined with a tubular apocrine adenoma. (22148038)
2011
15
Linear syringocystadenoma papilliferum: an uncommon event with a favorable prognosis. (21906485)
2011
16
Syringocystadenoma papilliferum: Unusual location. (21696687)
2011
17
A Case of Tubular Apocrine Adenoma with Syringocystadenoma Papilliferum that Developed in a Nevus Sebaceus. (20711270)
2010
18
Mucoepidermoid (adenosquamous) carcinoma, trichoblastoma, trichilemmoma, sebaceous adenoma, tumor of follicular infundibulum and syringocystadenoma papilliferum arising within 2 persistent lesions of nevus sebaceous: report of a case. (19652586)
2009
19
Syringocystadenoma papilliferum-like lesion of the vulva. (18752136)
2008
20
Congenital syringocystadenoma papilliferum. (18304179)
2008
21
Ductal carcinoma arising from syringocystadenoma papilliferum in the external auditory canal. (17159662)
2007
22
Linear syringocystadenoma papilliferum of the scalp. (17243981)
2007
23
Trichoblastoma and syringocystadenoma papilliferum arising in naevus sebaceous in a 4-year-old boy. (17342802)
2007
24
Cutaneous leiomyosarcoma, trichoblastoma, and syringocystadenoma papilliferum arising from nevus sebaceus. (17343592)
2007
25
Syringocystadenoma papilliferum: a rare breast tumor in a young boy. (16953682)
2006
26
Giant naevoid syringocystadenoma papilliferum. (16159744)
2005
27
Sebaceous carcinoma, basal cell carcinoma, trichoadenoma, trichoblastoma, and syringocystadenoma papilliferum arising within a nevus sebaceus. (15606837)
2004
28
Tubular apocrine adenoma in association with syringocystadenoma papilliferum. (12639465)
2003
29
Syringocystadenoma papilliferum arising on the scrotum. (12822557)
2003
30
Multiple pigmented trichoblastomas and syringocystadenoma papilliferum in naevus sebaceous mimicking a malignant melanoma: a clinical dermoscopic-pathological case study. (14632818)
2003
31
A case of syringocystadenocarcinoma papilliferum in situ occurring partially in syringocystadenoma papilliferum. (12692383)
2003
32
Trichilemmoma and syringocystadenoma papilliferum arising in naevus sebaceous. (12009106)
2002
33
An immunohistochemical and ultrastructural study of syringocystadenoma papilliferum. (12410704)
2002
34
Syringocystadenoma papilliferum: a study of potential tumor suppressor genes. (11285401)
2001
35
Linear syringocystadenoma papilliferum of the thigh. (11423852)
2001
36
Mixed syringocystadenoma papilliferum and papillary eccrine adenoma occurring in a scrotal condyloma. (10774942)
2000
37
Syringocystadenoma papilliferum presenting as a cutaneous horn. (10848760)
2000
38
Syringocystadenoma papilliferum mimicking breast carcinoma. (10698227)
2000
39
Syringocystadenoma papilliferum, basal cell carcinoma and trichilemmoma arising from nevus sebaceus of Jadassohn. (9188887)
1997
40
Fine needle aspiration cytology of chondroid syringoma and syringocystadenoma papilliferum. A report of two cases. (8392255)
1993
41
Syringocystadenoma papilliferum: report of an unusual case. (1661713)
1991
42
Syringocystadenoma papilliferum. (1661711)
1991
43
Nevus sebaceus, syringocystadenoma papilliferum, and basal cell epithelioma. (2995466)
1985
44
Syringocystadenoma papilliferum. A plasmacytotropic tumor. (2996375)
1985
45
Congenital papillated apocrine cystadenoma: a mixed form of hidrocystoma, hidradenoma papilliferum, and syringocystadenoma papilliferum. (6090513)
1984
46
Syringocystadenoma papilliferum in an unusual location. Report of a case. (182084)
1976
47
Syringocystadenoma papilliferum: light and electron microscopic studies. (78616)
1976
48
Syringocystadenoma papilliferum. An electron microscopic study. (4345083)
1972
49
A mixed tumor occurring as a syringocystadenoma papilliferum with a nevus sebaceus; report of a case. (13486945)
1958
50
Syringocystadenoma papilliferum, nevus sebaceus and basal-cell epithelioma (with features of epithelioma adenoides cysticum and syringoma); their concurrent presence in a single tumor; report of a case. (14901605)
1951

Variations for Syringocystadenoma Papilliferum

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Expression for genes affiliated with Syringocystadenoma Papilliferum

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Search GEO for disease gene expression data for Syringocystadenoma Papilliferum.

Pathways for genes affiliated with Syringocystadenoma Papilliferum

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GO Terms for genes affiliated with Syringocystadenoma Papilliferum

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Cellular components related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell bodyGO:00442979.4ACTC1, BRAF, GFAP
2intermediate filament cytoskeletonGO:00451119.3DES, GFAP, VIM
3intermediate filamentGO:00058829.3DES, GFAP, VIM
4cytosolGO:00058297.4ACTC1, BRAF, DES, GFAP, KRAS, VIM
5cytoplasmGO:00057376.7ACTC1, BRAF, DES, GFAP, KRAS, S100B

Biological processes related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:00600209.7GFAP, VIM
2intermediate filament-based processGO:00451039.7GFAP, VIM
3visual learningGO:00085429.7BRAF, KRAS
4astrocyte developmentGO:00140029.3GFAP, VIM
5long-term synaptic potentiationGO:00602919.1BRAF, GFAP, S100B
6negative regulation of neuron projection developmentGO:00109779.1GFAP, VIM
7intermediate filament organizationGO:00451098.9DES, GFAP, VIM
8muscle filament slidingGO:00300498.8ACTC1, DES, VIM
9positive regulation of gene expressionGO:00106288.5ACTC1, BRAF, KRAS, VIM

Molecular functions related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052008.9DES, GFAP, VIM
2identical protein bindingGO:00428028.1BRAF, DES, S100B, VIM

Sources for Syringocystadenoma Papilliferum

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet