SCAP
MCID: SYR002
MIFTS: 41

Syringocystadenoma Papilliferum (SCAP) malady

Categories: Rare diseases, Skin diseases, Cancer diseases

Aliases & Classifications for Syringocystadenoma Papilliferum

Aliases & Descriptions for Syringocystadenoma Papilliferum:

Name: Syringocystadenoma Papilliferum 12 50 56 14 69
Fistulous Vegetative Verrucous Hydradenoma 50 56
Naevus Syringocystadenomatosus Papilliferus 56
Syringadenoma Papilliferum 56
Papillary Syringadenoma 12
Papillary Hidradenoma 69
Scap 56

Characteristics:

Orphanet epidemiological data:

56
syringocystadenoma papilliferum
Inheritance: Not applicable; Age of onset: Adolescent,Childhood,Infancy,Neonatal;

Classifications:

Orphanet: 56  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:5445
NCIt 47 C4172
SNOMED-CT 64 239121009 8934006
Orphanet 56 ORPHA840
UMLS via Orphanet 70 C0406803
ICD10 via Orphanet 34 D23.9
UMLS 69 C0406803

Summaries for Syringocystadenoma Papilliferum

MalaCards based summary : Syringocystadenoma Papilliferum, also known as fistulous vegetative verrucous hydradenoma, is related to sebaceous adenoma and adenoma, and has symptoms including subcutaneous nodule, abnormal blistering of the skin and sparse scalp hair. An important gene associated with Syringocystadenoma Papilliferum is DES (Desmin), and among its related pathways/superpathways are ERK Signaling and Development ERBB-family signaling. Affiliated tissues include skin, breast and lung, and related phenotypes are Decreased viability and behavior/neurological

Wikipedia : 71 Syringocystadenoma papilliferum (also known as \"Syringadenoma papilliferum\") is a benign apocrine... more...

Related Diseases for Syringocystadenoma Papilliferum

Diseases related to Syringocystadenoma Papilliferum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 202)
id Related Disease Score Top Affiliating Genes
1 sebaceous adenoma 29.9 DES MUC1 VIM
2 adenoma 10.5
3 apocrine adenoma 10.4
4 basal cell carcinoma 10.4
5 glucosidase acid-1,4-alpha deficiency 10.3 DES GFAP
6 hidradenoma 10.3
7 invasive malignant thymoma 10.2 DES MUC1
8 13q12.3 microdeletion syndrome 10.2 DES VIM
9 episodic ataxia 10.2 DES MUC1
10 polydactyly cleft lip palate psychomotor retardation 10.2 DES MUC1
11 inflammatory linear verrucous epidermal nevus 10.2 DES VIM
12 lymphomatous thyroiditis 10.2 DES VIM
13 intrahepatic bile duct cystadenoma 10.2 DES S100B
14 osteomyelitis 10.2 DES VIM
15 congenital myasthenic syndrome 10.2 DES VIM
16 malignant dermis tumor 10.2 DES VIM
17 adult endodermal sinus tumor 10.2 DES VIM
18 foix-alajouanine syndrome 10.2 DES S100B
19 pseudohermaphrodism anorectal anomalies 10.2 DES MUC1
20 biemond syndrome 10.2 DES VIM
21 liver angiosarcoma 10.2 DES VIM
22 intestinal obstruction 10.2 DES VIM
23 bronchial mucus gland adenoma 10.2 GFAP S100B
24 male urethral cancer 10.2 DES VIM
25 nephrogenic adenoma of urinary bladder 10.2 GFAP VIM
26 adenofibroma 10.2 GFAP S100B
27 adult brainstem gliosarcoma 10.2 GFAP VIM
28 lucey-driscoll syndrome 10.2 MUC1 S100B
29 secondary pulmonary hemosiderosis 10.2 MUC1 S100B
30 invasive mole 10.2 MUC1 S100B
31 glomangioma 10.2 DES VIM
32 pemphigus vegetans 10.2 MUC1 S100B
33 immunodeficiency due to a classical component pathway complement deficiency 10.2 MUC1 VIM
34 piussan lenaerts mathieu syndrome 10.2 GFAP S100B
35 corneal intraepithelial neoplasm 10.2 MUC1 S100B
36 bladder adenocarcinoma 10.2 MUC1 VIM
37 calcific tendinitis 10.2 GFAP VIM
38 avian influenza 10.2 MUC1 VIM
39 endocardium cancer 10.2 MUC1 S100B
40 testicular granulosa cell tumor 10.2 MUC1 VIM
41 auricular cancer 10.2 GFAP S100B
42 vulvar angiokeratoma 10.2 MUC1 VIM
43 t-cell childhood lymphoblastic lymphoma 10.2 DES VIM
44 progeria 10.2 MUC1 VIM
45 pediculus humanus corporis infestation 10.2 GFAP S100B
46 lupus - neurological sequelae 10.2 S100B VIM
47 childhood medulloblastoma 10.2 DES GFAP
48 benign schwannoma 10.2 S100B VIM
49 pilar sheath acanthoma 10.2 DES VIM
50 gestational trophoblastic neoplasm 10.2 MUC1 VIM

Graphical network of the top 20 diseases related to Syringocystadenoma Papilliferum:



Diseases related to Syringocystadenoma Papilliferum

Symptoms & Phenotypes for Syringocystadenoma Papilliferum

Human phenotypes related to Syringocystadenoma Papilliferum:

56 32
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 subcutaneous nodule 56 32 Very frequent (99-80%) HP:0001482
2 abnormal blistering of the skin 56 32 Frequent (79-30%) HP:0008066
3 sparse scalp hair 56 32 Very frequent (99-80%) HP:0002209
4 papule 56 32 Very frequent (99-80%) HP:0200034
5 nevus sebaceous 56 32 Occasional (29-5%) HP:0010815

GenomeRNAi Phenotypes related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.36 KRAS MUC1 BRAF
2 Decreased viability GR00106-A-0 9.36 KRAS
3 Decreased viability GR00221-A-1 9.36 KRAS
4 Decreased viability GR00221-A-2 9.36 KRAS
5 Decreased viability GR00221-A-4 9.36 BRAF
6 Decreased viability GR00301-A 9.36 KRAS BRAF
7 Decreased viability GR00381-A-1 9.36 BRAF KRAS
8 Decreased cell migration GR00055-A-1 9.26 BRAF KRAS MUC1 VIM

MGI Mouse Phenotypes related to Syringocystadenoma Papilliferum:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.43 BRAF DES GFAP KRAS S100B VIM
2 muscle MP:0005369 9.02 BRAF DES GFAP KRAS VIM

Drugs & Therapeutics for Syringocystadenoma Papilliferum

Search Clinical Trials , NIH Clinical Center for Syringocystadenoma Papilliferum

Genetic Tests for Syringocystadenoma Papilliferum

Anatomical Context for Syringocystadenoma Papilliferum

MalaCards organs/tissues related to Syringocystadenoma Papilliferum:

39
Skin, Breast, Lung

Publications for Syringocystadenoma Papilliferum

Articles related to Syringocystadenoma Papilliferum:

(show top 50) (show all 147)
id Title Authors Year
1
Syringocystadenoma Papilliferum of the Scalp Arising from a Nevus Sebaceous. ( 27761094 )
2016
2
Syringocystadenoma papilliferum of the external auditory canal. Case report and literature review. ( 27658577 )
2016
3
Syringocystadenoma papilliferum with multiple lung metastases and long survival. ( 27837643 )
2016
4
Tubulopapillary Cystic Adenoma With Apocrine Differentiation: A Unifying Concept for Syringocystadenoma Papilliferum, Apocrine Gland Cyst, and Tubular Papillary Adenoma. ( 28033156 )
2016
5
Somatic V600E BRAF Mutation in Linear and Sporadic Syringocystadenoma Papilliferum. ( 25950823 )
2015
6
Tricholemmoma, sebaceoma, syringocystadenoma papilliferum, basal cell carcinoma, trichilemmal cyst arising within a nevus sebaceous. ( 26224239 )
2015
7
Fifteen year natural history of lower eyelid syringocystadenoma papilliferum in a young girl. ( 26097022 )
2015
8
Syringocystadenoma papilliferum in an unusual location. ( 26734876 )
2015
9
Somatic BRAF c.1799T>A p.V600E Mosaicism syndrome characterized by a linear syringocystadenoma papilliferum, anaplastic astrocytoma, and ocular abnormalities. ( 26360803 )
2015
10
A case of syringocystadenoma papilliferum of eyelid with literature review. ( 26265653 )
2015
11
Multiple pigmented trichoblastomas, sebaceous carcinoma and syringocystadenoma papilliferum arising within a nevus sebaceous. ( 25906325 )
2015
12
Activating mutations in the RAS/mitogen-activated protein kinase signaling pathway in sporadic trichoblastoma and syringocystadenoma papilliferum. ( 25532942 )
2015
13
Basal Cell Carcinoma and Syringocystadenoma Papilliferum Arising in Nevus Sebaceous on Face-A Rare Entity. ( 26677302 )
2015
14
Trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma, and tumor of the follicular infundibulum with signet-ring cells, all arising in nevus sebaceus. ( 25761672 )
2015
15
Eruptive Syringocystadenoma Papilliferum, Keratoacanthoma, and Verruca Vulgaris in a Keratinocytic Epidermal Nevus on the Leg. ( 26790513 )
2015
16
Cytological diagnosis of syringocystadenoma papilliferum a rare adnexal tumor. ( 26229253 )
2015
17
Syringocystadenoma papilliferum of the male nipple. ( 26269194 )
2015
18
Syringocystadenoma papilliferum arising on naevus sebaceus: A 6-year-old child case described with dermoscopic features. ( 25900640 )
2015
19
Syringocystadenoma papilliferum developing over hyperkeratosis of the nipple in a pregnant woman. ( 24629369 )
2014
20
Syringocystadenoma papilliferum of the upper lip. ( 25364565 )
2014
21
Linear syringocystadenoma papilliferum on female breast: a rare appendageal tumour on an uncommon location. ( 25756479 )
2014
22
Syringocystadenoma papilliferum: an unusual presentation. ( 24995228 )
2014
23
A case of syringocystadenoma papilliferum on lower leg: a rare location. ( 24082194 )
2013
24
Syringocystadenoma papilliferum in the right lower abdomen: a case report and review of literature. ( 23569386 )
2013
25
Syringocystadenoma papilliferum of the bony external auditory canal: a rare tumor in a rare location. ( 23762705 )
2013
26
Syringocystadenoma papilliferum of the scalp in an adult male - a case report. ( 23730665 )
2013
27
Linear syringocystadenoma papilliferum: a case report with review of literature. ( 24082219 )
2013
28
Syringocystadenoma papilliferum on the dorsum of the foot. ( 23621843 )
2013
29
Agminated syringocystadenoma papilliferum: a new clinical presentation of a rare benign adnexal neoplasm. ( 24021448 )
2013
30
Follicular hybrid cyst with isthmic-catagen, pilomatrical, and syringocystadenoma papilliferum components. ( 22699865 )
2013
31
Syringocystadenoma papilliferum arising on the scrotum. ( 22612442 )
2013
32
Giant linear syringocystadenoma papilliferum of the back. ( 22199089 )
2012
33
Adult-onset linear syringocystadenoma papilliferum over the inguinal fold: a case report with emphasis on mast cell staining pattern. ( 23217957 )
2012
34
Carcino-sarcoma in a case of syringocystadenoma papilliferum: a rare entity. ( 24765470 )
2012
35
Hidradenoma papilliferum with mixed histopathologic features of syringocystadenoma papilliferum and anogenital mammary-like glands: report of a case and review of the literature. ( 22262361 )
2012
36
Squamous cell carcinoma, syringocystadenoma papilliferum and apocrine adenoma arising in a nevus sebaceus of Jadassohn. ( 21393932 )
2011
37
Linear syringocystadenoma papilliferum: an unusual location. ( 21276059 )
2011
38
Syringocystadenoma papilliferum on the male nipple. ( 21914158 )
2011
39
Linear syringocystadenoma papilliferum: an uncommon event with a favorable prognosis. ( 21906485 )
2011
40
Dermoscopic aspects of syringocystadenoma papilliferum associated with nevus sebaceus. ( 22281917 )
2011
41
Syringocystadenoma papilliferum. ( 22372162 )
2011
42
Syringocystadenoma Papilliferum in Co-existence with Tubular Apocrine Adenoma on the Calf. ( 22148043 )
2011
43
Syringocystadenoma papilliferum of the back combined with a tubular apocrine adenoma. ( 22148038 )
2011
44
Basal cell carcinoma, syringocystadenoma papilliferum, trichilemmoma, and sebaceoma arising within a nevus sebaceus associated with pigmented nevi. ( 22093024 )
2011
45
Lipomatous apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. ( 21854651 )
2011
46
What is your diagnosis? Syringocystadenoma papilliferum. ( 22017063 )
2011
47
Report of 3 histopathologically documented cases of syringocystadenoma papilliferum involving the eyelid. ( 21784220 )
2011
48
Syringocystadenoma papilliferum: Unusual location. ( 21696687 )
2011
49
Syringocystadenoma papilliferum in an unusual location beyond the head and neck region: a case report and review of literature. ( 21062598 )
2010
50
A case of zonal syringocystadenoma papilliferum of the axilla mimicking verruca vulgaris. ( 20098083 )
2010

Variations for Syringocystadenoma Papilliferum

Expression for Syringocystadenoma Papilliferum

Search GEO for disease gene expression data for Syringocystadenoma Papilliferum.

Pathways for Syringocystadenoma Papilliferum

GO Terms for Syringocystadenoma Papilliferum

Cellular components related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.7 BRAF DES GFAP KRAS MUC1 S100B
2 intermediate filament cytoskeleton GO:0045111 8.96 DES GFAP
3 intermediate filament GO:0005882 8.8 DES GFAP VIM

Biological processes related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.5 BRAF KRAS VIM
2 visual learning GO:0008542 9.26 BRAF KRAS
3 long-term synaptic potentiation GO:0060291 9.16 BRAF S100B
4 muscle filament sliding GO:0030049 8.96 DES VIM
5 intermediate filament organization GO:0045109 8.62 DES VIM

Molecular functions related to Syringocystadenoma Papilliferum according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.13 DES GFAP VIM
2 identical protein binding GO:0042802 9.02 BRAF DES GFAP S100B VIM

Sources for Syringocystadenoma Papilliferum

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11 DGIdb
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59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
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70 UMLS via Orphanet
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