MCID: SYR003
MIFTS: 39

Syringoma malady

Rare diseases, Cancer diseases, Skin diseases, Immune diseases, Muscle diseases categories

Aliases & Classifications for Syringoma

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Aliases & Descriptions for Syringoma:

Name: Syringoma 10 45 47 12 65 36
 
Syringoma Nos 10


Classifications:



External Ids:

Disease Ontology10 DOID:2065
NCIt42 C3761
MeSH36 D018252

Summaries for Syringoma

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NIH Rare Diseases:45 Syringomas are firm yellowish, translucent, or skin colored papules that are often found on the face, particularly around the eyes. they may occur suddenly in crops or multiples. they arise from the sweat ducts. they usually cause no symptoms. they are not associated with underlying abnormality. they are found more commonly in caucasians, and in females at puberty or near middle-age. last updated: 8/6/2009

MalaCards based summary: Syringoma, also known as syringoma nos, is related to adenoma and vulvar syringoma. An important gene associated with Syringoma is S100B (S100 Calcium Binding Protein B), and among its related pathways are Aurora B signaling and Nuclear signaling by ERBB4. Affiliated tissues include skin, eye and salivary gland, and related mouse phenotypes are muscle and behavior/neurological.

Wikipedia:68 Syringomas are harmless sweat duct tumors, typically found clustered on eyelids, although they may also... more...

Related Diseases for Syringoma

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Diseases in the Syringoma family:

Malignant Syringoma

Diseases related to Syringoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 211)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.9MUC1, VIM
2vulvar syringoma29.3DES, ESR1, GFAP, MUC1, S100B, SERPINB5
3malignant syringoma10.4
4pleomorphic adenoma10.3
5orbit embryonal rhabdomyosarcoma10.3MUC1, VIM
6thyroid carcinoma with thyrotoxicosis10.3MUC1, VIM
7body skin hyperlaxity due to vitamin k-dependent coagulation factor deficiency10.3S100B, VIM
8vulvar nodular hidradenoma10.3MUC1, VIM
9hypersomnia10.3S100B, VIM
10hand dermatosis10.3MUC1, VIM
11beemer ertbruggen syndrome10.3S100B, VIM
12bladder urachal adenocarcinoma10.3MUC1, VIM
13gallbladder endocrine tumor10.2S100B, VIM
14histidine metabolism disease10.2MUC1, VIM
15localized lipodystrophy10.2MUC1, S100B
16complex regional pain syndrome type 110.2MUC1, S100B
17multilocular cystic renal cell carcinoma10.2MUC1, VIM
18prostate adenoid cystic carcinoma10.2MUC1, VIM
19extraneural perineurioma10.2MUC1, S100B
20infiltrating bladder lymphoepithelioma-like carcinoma10.2MUC1, VIM
21carney complex-trismus-pseudocamptodactyly syndrome10.2MUC1, VIM
22chondroid syringoma of the vulva10.2
23syringocystadenoma papilliferum10.2
24syringomas natal teeth oligodontia10.2
25pituitary dermoid and epidermoid cysts10.2MUC1, S100B
26ovarian gonadoblastoma10.2MUC1, VIM
27fibrous synovial sarcoma10.2MUC1, VIM
28odontoma10.2S100B, VIM
29large cell acanthoma10.2S100B, VIM
30osteogenesis imperfecta congenita microcephaly and cataracts10.2MUC1, VIM
31penis non-invasive verrucous carcinoma10.2MUC1, S100B
32scrotum basal cell carcinoma10.2MUC1, S100B
33squamous papillomatosis10.2MUC1, VIM
34malignant cystic nephroma10.2ESR1, MUC1
35infantile free sialic acid storage disease10.2DES, VIM
36lymphatic neoplasm10.2DES, VIM
37rhabdomyosarcoma10.2GFAP, VIM
38fundus dystrophy10.2MUC1, S100B
39esophageal lipoma10.2DES, VIM
40esophageal disease10.2DES, VIM
41bladder colonic type adenocarcinoma10.2DES, VIM
42carotenemia10.2GFAP, VIM
43autosomal dominant medullary cystic kidney disease with hyperuricemia10.2MUC1, S100B
44benign multicystic peritoneal mesothelioma10.2DES, VIM
45epidemic typhus10.2GFAP, VIM
46necrotizing fasciitis10.2DES, MUC1
47psoriasis10.2DES, VIM
48breast granular cell tumor10.2ESR1, MUC1
49spinocerebellar ataxia10.2DES, MUC1
50supine hypotensive syndrome10.2GFAP, VIM

Graphical network of the top 20 diseases related to Syringoma:



Diseases related to syringoma

Symptoms for Syringoma

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Drugs & Therapeutics for Syringoma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Trial of Radiotherapy and Panitumumab in Salivary Gland MalignanciesWithdrawnNCT00984217Phase 2

Search NIH Clinical Center for Syringoma


Cochrane evidence based reviews: Syringoma

Genetic Tests for Syringoma

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Anatomical Context for Syringoma

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MalaCards organs/tissues related to Syringoma:

33
Skin, Eye, Salivary gland, Bone, Breast, Lymph node, Spinal cord

Animal Models for Syringoma or affiliated genes

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MGI Mouse Phenotypes related to Syringoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.5DES, ESR1, GFAP, TP63, VIM
2MP:00053867.2DES, ESR1, GFAP, S100B, TP63, VIM

Publications for Syringoma

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Articles related to Syringoma:

(show top 50)    (show all 337)
idTitleAuthorsYear
1
Chondroid syringoma with extensive bone formation: a case report and review of the literature. (25478357)
2014
2
Chondroid syringoma with extensive osseous differentiation: a rare finding. (24943789)
2014
3
Chondroid syringoma of the medial canthus. (24744935)
2014
4
A curious serendipitous finding: Spitz naevus combined with a syringoma. (22671019)
2013
5
Penile syringoma: reports and review of patients with syringoma located on the penis. (23882308)
2013
6
Giant chondroid syringoma of the eyelid. (23931483)
2013
7
Facial localization of malignant chondroid syringoma: a rare case report. (23476847)
2013
8
Eruptive milium-like syringoma showing eccrine duct origin of milia. (22150478)
2012
9
Mohs micrographic surgery for recurrent chondroid syringoma of the eyebrow. (22309155)
2012
10
Commentary: treatment of syringoma using an ablative 10,600-nm carbon dioxide fractional laser. (21481062)
2011
11
Chondroid syringoma of the scalp: case report and discussion of clinical features, histopathology, and treatment. (21500172)
2011
12
Malignant chondroid syringoma: report of a case with lymph node metastasis 12 years after local excision. (21971270)
2011
13
Eruptive widespread papular eruption on the abdomen: a quiz. Clear cell syringoma, eruptive variant. (21264456)
2011
14
Autosomal dominant multiple syringomas linked to chromosome 16q22. (20132207)
2010
15
Eruptive syringoma associated with hyperthyroidism. (20527152)
2010
16
Milia with calcium deposits on the palms and soles in a patient with multiple syringoma. (20653855)
2010
17
Autoimmune acrosyringitis with ductal cysts: reclassification of case of eruptive syringoma. (19522848)
2009
18
Chondroid syringoma: a rare tumor of orofacial region. (19633639)
2009
19
Eruptive syringoma developed over a waxing skin area. (18645310)
2008
20
Syringoma-like eccrine sweat duct proliferation induced by radiation. (16469082)
2006
21
Periorbital syringoma: a pilot study of the efficacy of low-voltage electrocoagulation. (17034373)
2006
22
A rare case of chondroid syringoma arising from the lower eyelid with ectropion. (17051093)
2006
23
Elevated levels of serum carcinoembryonic antigen in a patient with eruptive syringoma. (16112373)
2005
24
Eruptive syringoma in four Black South African children. (15550160)
2004
25
Chondroid syringoma. Cytokeratin 20 immunolocalization of Merkel cells and reappraisal of apocrine folliculo-sebaceous differentiation. (15335266)
2004
26
Chondroid syringoma of the upper lip: a case report. (16027488)
2004
27
Cutaneous benign mixed tumor (chondroid syringoma) of the eyelid: clinical presentation and management. (15083078)
2004
28
Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma, spiradenoma, and syringoma. (14739501)
2004
29
Multiple syringomas in an unusual distribution. (14673269)
2003
30
Chondroid syringoma. A case report. (12038117)
2002
31
High-dose-rate endobronchial brachytherapy in endobronchial metastatic malignant chondroid syringoma. (11464090)
2001
32
Vulvar syringoma causing pruritus and carcinophobia: treatment by argon laser. (11360416)
1999
33
Eruptive syringoma. (20921761)
1998
34
Chondroid syringoma: an immunohistochemical study using antibodies to Ca 15-3, KA-93, Ca 19-9, CD44 and BM-1. (9001983)
1996
35
Hyaline cell-rich chondroid syringoma: epithelial nature of the hyaline cells. (8765182)
1996
36
Milium-like syringoma in the perianal region. (8534946)
1995
37
Chondroid syringoma. A rare occurrence in the hallux. (8394420)
1993
38
Fine needle aspiration cytology of chondroid syringoma and syringocystadenoma papilliferum. A report of two cases. (8392255)
1993
39
Eruptive syringoma. (8388104)
1993
40
Subclinical syringoma coexisting with nevocellular nevus on the vulva. (8478501)
1993
41
Generalised eruptive syringoma--a papular dermatosis. (1965678)
1990
42
Syringoma presenting as milia. (3819065)
1987
43
Multiple penile papules. Syringoma. (3662576)
1987
44
Syringoma of the ankle. (6715599)
1984
45
Chondroid syringoma. (6100183)
1984
46
Syringoma of the forehead. (6840942)
1983
47
Acral syringoma: electron microscopic studies on its origin. (6175141)
1982
48
Chondroid syringoma (mixed tumour) of radius. (6266947)
1981
49
Ultrastructure of chondroid syringoma: role of the myoepithelial cell in the development of the mixed tumor of the skin and soft tissues. (222430)
1979
50
Metastasising chondroid syringoma. (4352760)
1973

Variations for Syringoma

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Expression for genes affiliated with Syringoma

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Search GEO for disease gene expression data for Syringoma.

Pathways for genes affiliated with Syringoma

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Pathways related to Syringoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1DES, VIM
2
Show member pathways
9.1ESR1, GFAP, S100B
39.0SERPINB5, TP63, VIM
4
Show member pathways
8.7DES, GFAP, VIM

GO Terms for genes affiliated with Syringoma

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Cellular components related to Syringoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:00007909.4ESR1, MUC1, TP63
2intermediate filamentGO:00058829.3DES, GFAP, VIM
3cytoplasmGO:00057376.4DES, ESR1, GFAP, MUC1, S100B, SERPINB5

Biological processes related to Syringoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1intermediate filament-based processGO:00451039.8GFAP, VIM
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.8MUC1, TP63
3intermediate filament organizationGO:00451099.8GFAP, VIM
4Bergmann glial cell differentiationGO:00600209.7GFAP, VIM
5negative regulation of neuron projection developmentGO:00109779.6GFAP, VIM
6astrocyte developmentGO:00140029.6GFAP, VIM
7epithelial cell developmentGO:00020649.5ESR1, TP63
8long-term synaptic potentiationGO:00602919.4GFAP, S100B
9muscle filament slidingGO:00300499.1DES, VIM

Molecular functions related to Syringoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:00051988.9DES, GFAP, VIM
2structural constituent of cytoskeletonGO:00052008.7DES, GFAP, VIM
3identical protein bindingGO:00428027.3DES, ESR1, S100B, TP63, VIM

Sources for Syringoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet