MCID: SYR003
MIFTS: 44

Syringoma malady

Summaries for Syringoma

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Syringomas are firm yellowish, translucent, or skin colored papules that are often found on the face, particularly around the eyes. they may occur suddenly in crops or multiples. they arise from the sweat ducts. they usually cause no symptoms. they are not associated with underlying abnormality. they are found more commonly in caucasians, and in females at puberty or near middle-age. last updated: 8/6/2009

MalaCards: Syringoma, also known as syringoma nos, is related to malignant syringoma and adenoma. An important gene associated with Syringoma is KRT1 (keratin 1), and among its related pathways are Type I hemidesmosome assembly and Prolactin receptor signaling. The compounds estrogen and Ethynodiol Diacetate have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and salivary gland, and related mouse phenotype integument.

Wikipedia:64 Syringomas are harmless sweat duct tumors, typically found clustered on eyelids, although they may also... more...

Aliases & Classifications for Syringoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

syringoma 8 43 10 45 61
syringoma nos 8


External Ids:

Disease Ontology8 DOID:2065
NCIt40 C3761
MeSH35 D018252

Related Diseases for Syringoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Syringoma family:

malignant syringoma multiple syringomas

Diseases related to Syringoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 179)
idRelated DiseaseScoreTop Affiliating Genes
1malignant syringoma31.0DAND5
2adenoma30.4S100A1, MUC1, KRT19, KRT14, KRT20, CEACAM3
3pleomorphic adenoma30.3S100B, S100A1, DES, MUC1, GFAP, KRT14
4syringocystadenoma papilliferum30.2CLEC2A, PIP
5spiradenoma30.1CLEC2A
6hidrocystoma30.1PIP, SGTA
7basal cell carcinoma30.1PIP, KRT19, KRT20
8adenoid cystic carcinoma29.8CEACAM3, KRT20, KRT14, KRT19, MUC1, S100A1
9adenocarcinoma29.8PIP, MUC1, PGR, KRT19, KRT5, KRT1
10vulvar syringoma10.5
11multiple syringomas10.4
12chondroid syringoma of the vulva10.1
13urticaria pigmentosa10.1
14alopecia10.1
15urticaria10.1
16steatocystoma multiplex10.1
17syringomas natal teeth oligodontia10.1
18cystadenoma10.0CEACAM3
19gallbladder cancer10.0CEACAM3
20renal oncocytoma10.0S100A1
21leukoplakia10.0KRT1
22thymoma10.0CEACAM3
23clear cell ependymoma10.0MUC1
24choroid plexus papilloma10.0GFAP
25eccrine porocarcinoma10.0MUC1
26colon adenocarcinoma10.0KRT20
27pilomatrixoma10.0CLEC2A
28thyroid cancer10.0KRT19
29keratosis10.0KRT1, CLEC2A
30craniopharyngioma10.0KRT14
31acanthoma10.0CLEC2A
32osteosarcoma10.0ESR1
33cystadenocarcinoma10.0CEACAM3, MUC1
34cerebral meningioma10.0PGR
35thymic carcinoma10.0CEACAM3, MUC1
36fibrous meningioma10.0S100B, MUC1
37secretory meningioma10.0MUC1
38nephrogenic adenoma10.0S100A1
39giant cell glioblastoma10.0GFAP
40anaplastic astrocytoma10.0GFAP
41perineurioma10.0S100B, MUC1
42lung cancer10.0MUC1, KRT19
43prion disease10.0GFAP
44langerhans-cell histiocytosis10.0S100A1, S100B
45sertoli-leydig cell tumor10.0PGR, MUC1
46epidermolysis bullosa simplex with mottled pigmentation10.0KRT5
47epithelial-myoepithelial carcinoma10.0KRT14
48myxopapillary ependymoma10.0GFAP, S100B
49papillary ependymoma10.0S100B, GFAP
50bladder carcinoma10.0KRT20, KRT19

Graphical network of the top 20 diseases related to Syringoma:



Diseases related to syringoma

Clinical Features for Syringoma

Drugs & Therapeutics for Syringoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Syringoma

Drug clinical trials:

Search ClinicalTrials for Syringoma

Search NIH Clinical Center for Syringoma

Search CenterWatch for Syringoma

Genetic Tests for Syringoma

Anatomical Context for Syringoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Syringoma:

33
Skin, Lymph node, Salivary gland, Breast

Animal Models for Syringoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Syringoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.2KRT14, KRT1, KRT5, KRT19, S100B

Publications for Syringoma

Sources:
51PubMed
See all sources

Articles related to Syringoma:

(show top 50)    (show all 311)
idTitleAuthorsYear
1
Eruptive syringoma localized in intertriginous areas. (24393317)
2014
2
Giant chondroid syringoma of the eyelid. (23931483)
2013
3
Facial localization of malignant chondroid syringoma: a rare case report. (23476847)
2013
4
Chondroid syringoma: a rare lid tumor. (23275227)
2013
5
Infiltrating syringomatous adenoma of the nipple: a case report. (24034396)
2013
6
Chondroid syringoma (mixed tumor) with tyrosine crystals. (23647029)
2013
7
Malignant chondroid syringoma of the face with bone invasion. (23095341)
2013
8
Case of generalized eruptive clear cell syringoma with diabetes mellitus. (22011086)
2012
9
Chondroid syringoma: a diagnosis by fine needle aspiration cytology. (23112529)
2012
10
Vulval Syringoma: First report of a case in an Egyptian female. (23130299)
2012
11
Malignant chondroid syringoma with central nervous system involvement. (22421860)
2012
12
Late-onset, eruptive syringoma in an elderly man: correlation with carbamazepine. (21953350)
2012
13
Autosomal dominant multiple syringomas linked to chromosome 16q22. (20132207)
2010
14
Milia with calcium deposits on the palms and soles in a patient with multiple syringoma. (20653855)
2010
15
Chondroid syringoma: a rare tumor of the chest wall. (20172178)
2010
16
Autoimmune acrosyringitis with ductal cysts: reclassification of case of eruptive syringoma. (19522848)
2009
17
Eccrine spiradenoma with chondroid syringoma in Blaschkoid distribution. (19915242)
2009
18
Giant facial chondroid syringoma. (19215274)
2009
19
Chondroid syringoma of the nasal soft tissue triangle. (19328357)
2009
20
Disseminated form of syringoma (eruptive syringoma) sparing the face-a rare presentation causing diagnostic challenge. (19271392)
2008
21
Plaque-type syringoma: two cases misdiagnosed as microcystic adnexal carcinoma. (18005172)
2008
22
Chondroid syringoma of the scrotum. (19138288)
2008
23
Chondroid syringoma in a child. (17958797)
2007
24
Syringoma-like eccrine sweat duct proliferation induced by radiation. (16469082)
2006
25
A case of Grover's disease with syringoma-like features and leukemia cutis. (16776721)
2006
26
Eruptive syringoma in four Black South African children. (15550160)
2004
27
Chondroid syringoma. (12553630)
2003
28
Eruptive syringoma: 27 new cases and review of the literature. (11683289)
2001
29
Clear cells of eccrine glands in a patient with clear cell syringoma associated with diabetes mellitus. (8494118)
1993
30
Eruptive syringoma mimicking urticaria pigmentosa. A case report. (8103261)
1993
31
Eruptive syringoma in a Chinese boy. (8444534)
1993
32
Atypical chondroid syringoma. (1652102)
1991
33
Generalised eruptive syringoma--a papular dermatosis. (1965678)
1990
34
Disseminated syringomas of the upper extremities. Case history and immunohistochemical and ultrastructural study. (1694147)
1990
35
Syringoma-like sweat duct proliferation in scalp alopecias. (2074282)
1990
36
Familial syringoma clinically suggesting milia. (2541180)
1989
37
Syringoma presenting as milia. (3819065)
1987
38
Chondroid syringoma. (2822820)
1987
39
Case report 450: Skeletal metastases secondary to malignant chondroid syringoma. (2827317)
1987
40
Chondroid syringoma of the upper lip: report of a case. (2427674)
1986
41
Response of multiple syringomas to isotretinoin. (2424215)
1986
42
Malignant syringoma of the eyelid. (6493709)
1984
43
Unilateral linear nevoidal syringoma. (7229146)
1981
44
Syringoma limited to genitalia of a preadolescent girl. (7035516)
1981
45
Sweat gland carcinoma with syringomatous features: a light microscopic and ultrastructural study. (455242)
1979
46
Malignant chondroid syringoma of the thigh. Report of a case with electron microscopy of the tumour. (169339)
1975
47
Syringoma. Three cases with vulvar involvement. (5008292)
1972
48
Chondroid syringoma. (4341139)
1972
49
Chondroid syringoma. Mixed tumor of skin, salivary gland type. (13907712)
1961
50
Syringoma. (20247748)
1947

Genetic Variations for Syringoma

Expression for genes affiliated with Syringoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Syringoma

Search GEO for disease gene expression data for Syringoma.

Pathways for genes affiliated with Syringoma

Sources:
54Reactome, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Syringoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0KRT14, KRT5
2
Hide members
9.9S100B, PGR, GFAP
3
Hide members
9.7S100B, PGR, GFAP, ESR1
49.6S100B, S100A1, MARCKS
59.4KRT19, KRT5, KRT1, KRT14

Compounds for genes affiliated with Syringoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Syringoma according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7GFAP
2Ethynodiol Diacetate1110.3PGR, ESR1
3ici 1643844510.3ESR1, PGR
4idoxifene4510.3PGR, ESR1
5eosin4510.3MUC1, S100B, GFAP
6Etonogestrel1110.2ESR1, PGR
7Allylestrenol1110.2ESR1, PGR
8triphenylethylene4510.1ESR1, PGR
9s 1004510.1MUC1, DES, S100B, GFAP
10reticulin4510.1GFAP, MUC1, DES, S100B
11progestin459.9PGR, DES, MUC1, ESR1
12indium459.8CEACAM3, MUC1
13biotin45 11 2411.8S100A1, DES, MUC1, KRT1
14creatinine459.8CEACAM3, KRT19, GFAP
15streptavidin459.7DES, CEACAM3, KRT20
1612-o-tetradecanoylphorbol 13-acetate459.5KRT5, KRT1, MARCKS, MUC1, DES
17progestins459.5ESR1, PGR, PIP
18glycogen45 2410.5MARCKS, GFAP, CSNK1A1
19paclitaxel45 50 1111.5S100B, PGR, GFAP, KRT19, ESR1
20dihydrotestosterone45 29 11 2412.4PIP, DES, PGR, MUC1, ESR1
21glucose459.4GFAP, KRT19, CEACAM3, KRT14, MUC1
22adriamycin459.4MUC1, KRT19, CEACAM3, DES, PGR
23phospholipid459.4S100A1, S100B, ANXA11, MARCKS, MUC1
24bromodeoxyuridine459.4DES, GFAP, KRT19, S100B, KRT1, KRT14
25proline459.4KRT5, KRT1, S100B, DES, KRT14
26retinoid459.3KRT1, PGR, KRT14, ESR1, KRT19, KRT5
2717beta-hydroxysteroid459.3PGR, ESR1, KRT19
28hyaluronic acid45 2410.3KRT20, KRT19, DES, MUC1
29doxorubicin45 50 1111.2KRT20, DES, PGR, CEACAM3, ESR1
30formaldehyde45 2410.2GFAP, KRT19, KRT20, DES, S100B, MUC1
31thymidine45 2410.2DES, MUC1, S100B, GFAP, KRT19, CEACAM3
32tamoxifen45 50 29 1112.1MUC1, PGR, CEACAM3, ESR1, PIP, KRT14
33aspartate459.0KRT5, S100B, KRT19, GFAP, PGR, CEACAM3
34alanine459.0KRT5, PGR, GFAP, CEACAM3, KRT14, S100B
35steroid458.9KRT1, ESR1, CEACAM3, DES, KRT19, PIP
36estradiol45 11 2410.8ESR1, KRT19, GFAP, PGR, MUC1, DES
37iron45 249.8DES, GFAP, KRT19, KRT14, KRT20, S100A1
38mucicarmine458.5KRT20, MUC1, DES, PIP, S100A1, KRT14
39vegf458.4DES, CEACAM3, ESR1, KRT20, S100B, KRT19
40b 723458.2CEACAM3, PIP, S100A1, S100B, KRT19, MUC1
41retinoic acid45 249.2KRT1, KRT19, KRT5, DES, KRT14, ESR1
42threonine458.2S100B, GFAP, KRT5, KRT1, KRT14, MUC1
43hematoxylin458.1CEACAM3, KRT14, KRT1, KRT19, GFAP, MUC1
44cysteine458.0DAND5, S100B, SGTA, GFAP, KRT14, PGR
45testosterone45 60 11 2410.8DES, MUC1, PGR, S100B, GFAP, KRT19
46serine457.7CSNK1A1, DES, MUC1, S100B, KRT19, KRT14
47calcium45 50 11 2410.6S100B, DES, KRT5, KRT14, CEACAM3, KRT19
48progesterone45 60 29 11 2411.0GFAP, KRT19, KRT5, KRT1, KRT14, KRT20
49paraffin456.9S100B, KRT1, KRT14, KRT20, CEACAM3, ESR1
50tyrosine456.7MUC1, GFAP, KRT5, CEACAM3, KRT1, KRT14

GO Terms for genes affiliated with Syringoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Syringoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.8KRT14, KRT1, KRT5
2intermediate filamentGO:0058828.4KRT20, KRT14, KRT5, KRT19, GFAP, DES

Biological processes related to Syringoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemidesmosome assemblyGO:03158110.0KRT14, KRT5
2intermediate filament organizationGO:0451099.6KRT20, GFAP

Molecular functions related to Syringoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:0445489.4S100A1, ANXA11, S100B
2structural constituent of cytoskeletonGO:0052008.6KRT20, KRT14, KRT5, KRT19, GFAP, DES
3protein bindingGO:0055155.6KRT14, ESR1, SGTA, S100B, S100A1, CSNK1A1

Products for genes affiliated with Syringoma

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  • Proteins
  • Lysates
  • Antibodies

Sources for Syringoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet