MCID: SYR003
MIFTS: 55

Syringoma malady

Rare diseases, Skin diseases, Immune diseases, Muscle diseases, Cancer diseases categories

Summaries for Syringoma

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NIH Rare Diseases:43 Syringomas are firm yellowish, translucent, or skin colored papules that are often found on the face, particularly around the eyes. they may occur suddenly in crops or multiples. they arise from the sweat ducts. they usually cause no symptoms. they are not associated with underlying abnormality. they are found more commonly in caucasians, and in females at puberty or near middle-age. last updated: 8/6/2009

MalaCards based summary: Syringoma, also known as syringoma nos, is related to adenoma and pleomorphic adenoma. An important gene associated with Syringoma is KRT1 (keratin 1), and among its related pathways are Aurora B signaling and Signaling mediated by p38-alpha and p38-beta. The compounds orcein and eosin have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and bone, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Wikipedia:65 Syringomas are harmless sweat duct tumors, typically found clustered on eyelids, although they may also... more...

Aliases & Classifications for Syringoma

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Syringoma, Aliases & Descriptions:

Name: Syringoma 10 43 12 45 62
 
Syringoma Nos 10


Classifications:



External Ids:

Disease Ontology10 DOID:2065
MeSH35 D018252
NCIt40 C3761

Related Diseases for Syringoma

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Diseases in the Syringoma family:

Malignant Syringoma

Diseases related to Syringoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.4S100A1, KRT14, MUC1, KRT19, CEACAM3
2pleomorphic adenoma30.3KRT14, DES, GFAP, S100B, VIM, MUC1
3hidradenoma30.0MUC1
4keratosis30.0KRT14, KRT1
5adenocarcinoma29.8KRT19, VIM, KRT14, KRT1, CEACAM3, MUC1
6vulvar syringoma10.5
7malignant syringoma10.3
8syringocystadenoma papilliferum10.2
9chondroid syringoma of the vulva10.2
10steatocystoma multiplex10.1
11alopecia10.1
12spiradenoma10.1
13adenoiditis10.1
14urticaria pigmentosa10.1
15hidrocystoma10.1
16down syndrome10.1
17basal cell carcinoma10.1
18calcinosis10.1
19hyperthyroidism10.1
20urticaria10.1
21syringomas natal teeth oligodontia10.1
22eccrine porocarcinoma10.1MUC1
23nephrogenic adenoma10.1S100A1
24subependymal giant cell astrocytoma10.1GFAP
25giant cell glioblastoma10.1GFAP
26mixed glioma10.1GFAP
27rosai-dorfman disease10.1S100B
28neurilemmoma10.1GFAP
29adenomatoid tumor10.1VIM
30fibrous meningioma10.0MUC1, S100B
31infantile myofibromatosis10.0DES
32langerhans-cell histiocytosis10.0S100A1, S100B
33cystadenocarcinoma10.0CEACAM3, MUC1
34mucinous cystadenocarcinoma10.0MUC1, CEACAM3
35myxopapillary ependymoma10.0GFAP, S100B
36paget disease, extramammary10.0MUC1, CEACAM3
37papillary ependymoma10.0S100B, GFAP
38choroid plexus carcinoma10.0GFAP, S100B
39thymic carcinoma10.0CEACAM3, MUC1
40gemistocytic astrocytoma10.0S100B, GFAP
41pineocytoma10.0S100B, GFAP
42clear cell ependymoma10.0VIM, MUC1
43epithelial-myoepithelial carcinoma10.0KRT14
44mammary paget's disease10.0ESR1, MUC1
45ganglioglioma10.0S100B, GFAP
46rhabdoid meningioma10.0VIM, GFAP
47secretory meningioma10.0VIM, MUC1
48malignant pleural mesothelioma10.0CEACAM3, MUC1
49astroblastoma10.0VIM, GFAP
50gastrointestinal carcinoma10.0KRT19, CEACAM3

Graphical network of the top 20 diseases related to Syringoma:



Diseases related to syringoma

Symptoms for Syringoma

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Drugs & Therapeutics for Syringoma

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Drug clinical trials:

Search ClinicalTrials for Syringoma

Search NIH Clinical Center for Syringoma

Genetic Tests for Syringoma

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Anatomical Context for Syringoma

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MalaCards organs/tissues related to Syringoma:

33
Skin, Eye, Bone, Salivary gland, Lymph node, Spinal cord, Breast

Animal Models for Syringoma or affiliated genes

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MGI Mouse Phenotypes related to Syringoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9KRT19, KRT14, MUC1, ESR1
2MP:00053818.7GFAP, ESR1, MUC1, KRT14, KRT19
3MP:00107718.5ESR1, MUC1, S100B, KRT14, KRT1, KRT19
4MP:00053698.4DES, GFAP, ESR1, VIM, S100A1
5MP:00028738.1GFAP, MUC1, S100A1, S100B, KRT19
6MP:00053768.1DES, GFAP, ESR1, VIM, MUC1, KRT14
7MP:00053868.0DES, GFAP, ESR1, VIM, S100A1, S100B
8MP:00053787.8DAND5, GFAP, ESR1, VIM, KRT14, KRT1
9MP:00107687.4DAND5, DES, GFAP, ESR1, VIM, KRT14
10MP:00053857.3KRT19, DAND5, DES, GFAP, ESR1, VIM

Publications for Syringoma

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Articles related to Syringoma:

(show top 50)    (show all 325)
idTitleAuthorsYear
1
Chondroid syringoma with extensive bone formation: a case report and review of the literature. (25478357)
2014
2
Chondroid syringoma with extensive osseous differentiation: a rare finding. (24943789)
2014
3
Chondroid syringoma of the medial canthus. (24744935)
2014
4
A curious serendipitous finding: Spitz naevus combined with a syringoma. (22671019)
2013
5
Penile syringoma: reports and review of patients with syringoma located on the penis. (23882308)
2013
6
Giant chondroid syringoma of the eyelid. (23931483)
2013
7
Facial localization of malignant chondroid syringoma: a rare case report. (23476847)
2013
8
Eruptive milium-like syringoma showing eccrine duct origin of milia. (22150478)
2012
9
Mohs micrographic surgery for recurrent chondroid syringoma of the eyebrow. (22309155)
2012
10
Commentary: treatment of syringoma using an ablative 10,600-nm carbon dioxide fractional laser. (21481062)
2011
11
Chondroid syringoma of the scalp: case report and discussion of clinical features, histopathology, and treatment. (21500172)
2011
12
Malignant chondroid syringoma: report of a case with lymph node metastasis 12 years after local excision. (21971270)
2011
13
Eruptive widespread papular eruption on the abdomen: a quiz. Clear cell syringoma, eruptive variant. (21264456)
2011
14
Autosomal dominant multiple syringomas linked to chromosome 16q22. (20132207)
2010
15
Eruptive syringoma associated with hyperthyroidism. (20527152)
2010
16
Milia with calcium deposits on the palms and soles in a patient with multiple syringoma. (20653855)
2010
17
Autoimmune acrosyringitis with ductal cysts: reclassification of case of eruptive syringoma. (19522848)
2009
18
Chondroid syringoma: a rare tumor of orofacial region. (19633639)
2009
19
Eruptive syringoma developed over a waxing skin area. (18645310)
2008
20
Syringoma-like eccrine sweat duct proliferation induced by radiation. (16469082)
2006
21
Periorbital syringoma: a pilot study of the efficacy of low-voltage electrocoagulation. (17034373)
2006
22
A rare case of chondroid syringoma arising from the lower eyelid with ectropion. (17051093)
2006
23
Elevated levels of serum carcinoembryonic antigen in a patient with eruptive syringoma. (16112373)
2005
24
Eruptive syringoma in four Black South African children. (15550160)
2004
25
Chondroid syringoma. Cytokeratin 20 immunolocalization of Merkel cells and reappraisal of apocrine folliculo-sebaceous differentiation. (15335266)
2004
26
Chondroid syringoma of the upper lip: a case report. (16027488)
2004
27
Cutaneous benign mixed tumor (chondroid syringoma) of the eyelid: clinical presentation and management. (15083078)
2004
28
Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma, spiradenoma, and syringoma. (14739501)
2004
29
Multiple syringomas in an unusual distribution. (14673269)
2003
30
Chondroid syringoma. A case report. (12038117)
2002
31
High-dose-rate endobronchial brachytherapy in endobronchial metastatic malignant chondroid syringoma. (11464090)
2001
32
Vulvar syringoma causing pruritus and carcinophobia: treatment by argon laser. (11360416)
1999
33
Eruptive syringoma. (20921761)
1998
34
Chondroid syringoma: an immunohistochemical study using antibodies to Ca 15-3, KA-93, Ca 19-9, CD44 and BM-1. (9001983)
1996
35
Hyaline cell-rich chondroid syringoma: epithelial nature of the hyaline cells. (8765182)
1996
36
Milium-like syringoma in the perianal region. (8534946)
1995
37
Chondroid syringoma. A rare occurrence in the hallux. (8394420)
1993
38
Fine needle aspiration cytology of chondroid syringoma and syringocystadenoma papilliferum. A report of two cases. (8392255)
1993
39
Eruptive syringoma. (8388104)
1993
40
Subclinical syringoma coexisting with nevocellular nevus on the vulva. (8478501)
1993
41
Generalised eruptive syringoma--a papular dermatosis. (1965678)
1990
42
Syringoma presenting as milia. (3819065)
1987
43
Multiple penile papules. Syringoma. (3662576)
1987
44
Syringoma of the ankle. (6715599)
1984
45
Chondroid syringoma. (6100183)
1984
46
Syringoma of the forehead. (6840942)
1983
47
Acral syringoma: electron microscopic studies on its origin. (6175141)
1982
48
Chondroid syringoma (mixed tumour) of radius. (6266947)
1981
49
Ultrastructure of chondroid syringoma: role of the myoepithelial cell in the development of the mixed tumor of the skin and soft tissues. (222430)
1979
50
Metastasising chondroid syringoma. (4352760)
1973

Variations for Syringoma

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Expression for genes affiliated with Syringoma

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Search GEO for disease gene expression data for Syringoma.

Pathways for genes affiliated with Syringoma

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Compounds for genes affiliated with Syringoma

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Compounds related to Syringoma according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1orcein459.7VIM, S100B, DES
2eosin459.5MUC1, VIM, GFAP, S100B
3progestin459.3MUC1, VIM, ESR1, DES
42-methoxyethanol459.3VIM, S100A1, KRT14
5toluidine459.3S100A1, DES, VIM
6s 100459.2GFAP, DES, VIM, MUC1, S100B
7reticulin459.2MUC1, S100B, DES, VIM, GFAP
8dihydrotestosterone45 30 26 1312.2DES, MUC1, VIM, ESR1
9chloramphenicol45 3 51 1312.0MUC1, ESR1, VIM, S100B, KRT14
10hyaluronic acid45 2610.0VIM, MUC1, DES, KRT19
11methionine458.9KRT14, S100B, VIM, GFAP, DES
12biotin45 26 1310.9KRT1, S100A1, MUC1, VIM, DES
13proline458.8DES, VIM, S100B, KRT14, KRT1
14butyrate458.8KRT19, KRT14, MUC1, VIM, GFAP
15retinoid458.8KRT19, ESR1, KRT1, KRT14, VIM
16paclitaxel45 51 1310.8S100B, VIM, KRT19, ESR1, GFAP
17threonine458.7GFAP, DES, MUC1, KRT14, S100B, KRT1
18acth458.6S100B, CEACAM3, GFAP, MUC1
19acetylcholine45 51 30 26 1312.6S100B, S100A1, VIM, GFAP, DES
20formaldehyde45 269.6S100B, MUC1, VIM, GFAP, KRT19, DES
21cisplatin45 51 61 1311.6GFAP, MUC1, ESR1, KRT19, KRT14
22methotrexate51 45 1310.6MUC1, CEACAM3, VIM, ESR1
23arginine458.6KRT14, DES, GFAP, VIM, S100B, KRT1
24estradiol45 26 1310.6MUC1, KRT19, ESR1, VIM, GFAP, DES
25tamoxifen45 51 30 1311.5KRT14, ESR1, VIM, MUC1, CEACAM3
26cyclic amp45 269.4VIM, MUC1, GFAP, DES, S100B
27adriamycin458.4CEACAM3, KRT19, MUC1, VIM, DES
28bromodeoxyuridine458.3KRT14, VIM, KRT19, KRT1, DES, S100B
29thymidine45 269.2GFAP, S100B, KRT19, CEACAM3, DES, MUC1
30aspartate458.1CEACAM3, VIM, S100B, GFAP, KRT1, KRT19
31steroid458.1S100B, KRT1, ESR1, DES, CEACAM3, KRT19
32lactate458.1CEACAM3, VIM, S100B, KRT19, DES, GFAP
33testosterone45 61 26 1311.0GFAP, VIM, DES, KRT19, KRT1, S100B
34glycogen45 269.0VIM, GFAP, DES, MUC1, S100A1, S100B
35oxygen45 268.9KRT19, CEACAM3, MUC1, GFAP, DES, S100B
36serine457.9MUC1, GFAP, DES, KRT19, VIM, KRT1
37iron45 268.9GFAP, KRT14, DES, S100B, S100A1, VIM
38creatinine457.8DES, GFAP, VIM, MUC1, S100B, CEACAM3
39glucose457.8DES, GFAP, MUC1, S100B, KRT14, KRT19
40mucicarmine457.7CEACAM3, MUC1, VIM, DES, S100B, KRT14
41cysteine457.6DES, GFAP, VIM, S100A1, DAND5, KRT14
42b 723457.5DES, VIM, MUC1, CEACAM3, S100A1, S100B
43vegf457.5CEACAM3, MUC1, VIM, S100B, GFAP, DES
44retinoic acid45 268.0KRT19, KRT1, KRT14, DES, S100B, S100A1
45tyrosine457.0DES, KRT19, GFAP, KRT1, KRT14, S100B
46calcium45 51 26 139.9GFAP, DES, MUC1, CEACAM3, S100A1, S100B
47hematoxylin456.5GFAP, KRT19, KRT1, KRT14, DES, S100B
48paraffin456.2GFAP, DES, ESR1, VIM, KRT19, KRT1
49estrogen456.2DES, GFAP, ESR1, MUC1, CEACAM3, S100A1
50progesterone45 30 61 26 1310.2KRT14, S100B, S100A1, CEACAM3, DES, MUC1

GO Terms for genes affiliated with Syringoma

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Cellular components related to Syringoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell peripheryGO:00719449.2KRT19, KRT14
2Z discGO:00300188.9DES, S100A1, KRT19
3extracellular vesicular exosomeGO:00700628.5KRT19, KRT1, KRT14, MUC1, VIM
4intermediate filamentGO:00058828.4KRT19, KRT14, VIM, GFAP, DES

Biological processes related to Syringoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1long-term synaptic potentiationGO:00602919.9GFAP, S100B
2Bergmann glial cell differentiationGO:00600209.8VIM, GFAP
3astrocyte developmentGO:00140029.8VIM, GFAP
4intermediate filament organizationGO:00451099.8VIM, GFAP
5muscle filament slidingGO:00300499.6VIM, DES
6negative regulation of neuron projection developmentGO:00109779.6VIM, GFAP
7regulation of heart contractionGO:00080169.2S100A1, DES

Molecular functions related to Syringoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-dependent protein bindingGO:00483069.6S100B, S100A1
2S100 protein bindingGO:00445489.3S100B, S100A1
3structural constituent of cytoskeletonGO:00052008.5KRT19, KRT14, VIM, GFAP, DES
4identical protein bindingGO:00428028.4DES, ESR1, VIM, S100A1, S100B
5protein bindingGO:00055156.8DES, ESR1, VIM, MUC1, S100A1, S100B

Products for genes affiliated with Syringoma

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Sources for Syringoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet