MCID: SYR003
MIFTS: 55

Syringoma malady

Rare diseases, Cancer diseases, Skin diseases categories
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Summaries for Syringoma

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Syringomas are firm yellowish, translucent, or skin colored papules that are often found on the face, particularly around the eyes. they may occur suddenly in crops or multiples. they arise from the sweat ducts. they usually cause no symptoms. they are not associated with underlying abnormality. they are found more commonly in caucasians, and in females at puberty or near middle-age. last updated: 8/6/2009

MalaCards: Syringoma, also known as syringoma nos, is related to adenoma and pleomorphic adenoma. An important gene associated with Syringoma is KRT1 (keratin 1), and among its related pathways are Aurora B signaling and Signaling mediated by p38-alpha and p38-beta. The compounds orcein and eosin have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and bone, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Wikipedia:65 Syringomas are harmless sweat duct tumors, typically found clustered on eyelids, although they may also... more...

Aliases & Classifications for Syringoma

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

syringoma 8 43 10 45 62
syringoma nos 8


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Disease Ontology8 DOID:2065
NCIt40 C3761
MeSH35 D018252

Related Diseases for Syringoma

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17GeneCards, 18GeneDecks
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Diseases in the Syringoma family:

Malignant Syringoma Multiple Syringomas

Diseases related to Syringoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 157)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.3MUC1, CEACAM3, S100A1, KRT14, KRT19
2pleomorphic adenoma30.1DES, GFAP, VIM, MUC1, S100A1, S100B
3hidradenoma30.1MUC1
4adenoid cystic carcinoma29.7KRT14, KRT19, S100B, S100A1, VIM, MUC1
5adenocarcinoma29.6ESR1, VIM, MUC1, CEACAM3, KRT14, KRT1
6vulvar syringoma10.5
7multiple syringomas10.4
8malignant syringoma10.3
9diabetes mellitus10.3
10syringocystadenoma papilliferum10.2
11eccrine porocarcinoma10.1MUC1
12nephrogenic adenoma10.1S100A1
13subependymal giant cell astrocytoma10.1GFAP
14giant cell glioblastoma10.1GFAP
15mixed glioma10.1GFAP
16rosai-dorfman disease10.1S100B
17neurilemmoma10.1GFAP
18adenomatoid tumor10.1VIM
19spiradenoma10.1
20chondroid syringoma of the vulva10.1
21adenoiditis10.1
22urticaria pigmentosa10.1
23hidrocystoma10.1
24down syndrome10.1
25alopecia10.1
26basal cell carcinoma10.1
27calcinosis10.1
28hyperthyroidism10.1
29urticaria10.1
30steatocystoma multiplex10.1
31syringomas natal teeth oligodontia10.1
32fibrous meningioma10.1MUC1, S100B
33infantile myofibromatosis10.1DES
34langerhans-cell histiocytosis10.1S100A1, S100B
35cystadenocarcinoma10.1MUC1, CEACAM3
36mucinous cystadenocarcinoma10.1CEACAM3, MUC1
37myxopapillary ependymoma10.1GFAP, S100B
38cutaneous paget's disease10.1MUC1, CEACAM3
39papillary ependymoma10.1GFAP, S100B
40choroid plexus carcinoma10.1GFAP, S100B
41thymus cancer10.1MUC1, CEACAM3
42gemistocytic astrocytoma10.1GFAP, S100B
43clear cell ependymoma10.1VIM, MUC1
44pineocytoma10.1S100B, GFAP
45epithelial-myoepithelial carcinoma10.1KRT14
46mammary paget's disease10.1MUC1, ESR1
47rhabdoid meningioma10.1GFAP, VIM
48ganglioglioma10.1GFAP, S100B
49malignant pleural mesothelioma10.1MUC1, CEACAM3
50astroblastoma10.1GFAP, VIM

Graphical network of the top 20 diseases related to Syringoma:



Diseases related to syringoma

Symptoms for Syringoma

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Drugs & Therapeutics for Syringoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Syringoma

Search NIH Clinical Center for Syringoma

Genetic Tests for Syringoma

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Anatomical Context for Syringoma

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33MalaCards
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MalaCards organs/tissues related to Syringoma:

33
Skin, Eye, Bone, Salivary gland, Lymph node, Breast

Animal Models for Syringoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Syringoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9KRT19, KRT14, MUC1, ESR1
2MP:00053818.7GFAP, ESR1, MUC1, KRT14, KRT19
3MP:00107718.5ESR1, MUC1, S100B, KRT14, KRT1, KRT19
4MP:00053698.4DES, GFAP, ESR1, VIM, S100A1
5MP:00028738.1GFAP, MUC1, S100A1, S100B, KRT19
6MP:00053768.1DES, GFAP, ESR1, VIM, MUC1, KRT14
7MP:00053868.0DES, GFAP, ESR1, VIM, S100A1, S100B
8MP:00053787.8DAND5, GFAP, ESR1, VIM, KRT14, KRT1
9MP:00107687.4DAND5, DES, GFAP, ESR1, VIM, KRT14
10MP:00053857.3KRT19, DAND5, DES, GFAP, ESR1, VIM

Publications for Syringoma

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52PubMed
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Articles related to Syringoma:

(show top 50)    (show all 303)
idTitleAuthorsYear
1
A curious serendipitous finding: Spitz naevus combined with a syringoma. (22671019)
2013
2
Penile syringoma: reports and review of patients with syringoma located on the penis. (23882308)
2013
3
Giant chondroid syringoma of the eyelid. (23931483)
2013
4
Facial localization of malignant chondroid syringoma: a rare case report. (23476847)
2013
5
Eruptive milium-like syringoma showing eccrine duct origin of milia. (22150478)
2012
6
Mohs micrographic surgery for recurrent chondroid syringoma of the eyebrow. (22309155)
2012
7
Commentary: treatment of syringoma using an ablative 10,600-nm carbon dioxide fractional laser. (21481062)
2011
8
Chondroid syringoma of the scalp: case report and discussion of clinical features, histopathology, and treatment. (21500172)
2011
9
Malignant chondroid syringoma: report of a case with lymph node metastasis 12 years after local excision. (21971270)
2011
10
Eruptive widespread papular eruption on the abdomen: a quiz. Clear cell syringoma, eruptive variant. (21264456)
2011
11
Autosomal dominant multiple syringomas linked to chromosome 16q22. (20132207)
2010
12
Eruptive syringoma associated with hyperthyroidism. (20527152)
2010
13
Milia with calcium deposits on the palms and soles in a patient with multiple syringoma. (20653855)
2010
14
Autoimmune acrosyringitis with ductal cysts: reclassification of case of eruptive syringoma. (19522848)
2009
15
Chondroid syringoma: a rare tumor of orofacial region. (19633639)
2009
16
Preoperative cytologic diagnosis of chondroid syringoma. (19798896)
2009
17
Eccrine spiradenoma with chondroid syringoma in Blaschkoid distribution. (19915242)
2009
18
Eruptive syringoma developed over a waxing skin area. (18645310)
2008
19
Syringoma-like eccrine sweat duct proliferation induced by radiation. (16469082)
2006
20
Periorbital syringoma: a pilot study of the efficacy of low-voltage electrocoagulation. (17034373)
2006
21
A rare case of chondroid syringoma arising from the lower eyelid with ectropion. (17051093)
2006
22
Elevated levels of serum carcinoembryonic antigen in a patient with eruptive syringoma. (16112373)
2005
23
Eruptive syringoma in four Black South African children. (15550160)
2004
24
Chondroid syringoma. Cytokeratin 20 immunolocalization of Merkel cells and reappraisal of apocrine folliculo-sebaceous differentiation. (15335266)
2004
25
Chondroid syringoma of the upper lip: a case report. (16027488)
2004
26
Cutaneous benign mixed tumor (chondroid syringoma) of the eyelid: clinical presentation and management. (15083078)
2004
27
Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma, spiradenoma, and syringoma. (14739501)
2004
28
Multiple syringomas in an unusual distribution. (14673269)
2003
29
Chondroid syringoma. A case report. (12038117)
2002
30
High-dose-rate endobronchial brachytherapy in endobronchial metastatic malignant chondroid syringoma. (11464090)
2001
31
Vulvar syringoma causing pruritus and carcinophobia: treatment by argon laser. (11360416)
1999
32
Eruptive syringoma. (20921761)
1998
33
Chondroid syringoma: an immunohistochemical study using antibodies to Ca 15-3, KA-93, Ca 19-9, CD44 and BM-1. (9001983)
1996
34
Hyaline cell-rich chondroid syringoma: epithelial nature of the hyaline cells. (8765182)
1996
35
Milium-like syringoma in the perianal region. (8534946)
1995
36
Chondroid syringoma. A rare occurrence in the hallux. (8394420)
1993
37
Fine needle aspiration cytology of chondroid syringoma and syringocystadenoma papilliferum. A report of two cases. (8392255)
1993
38
Eruptive syringoma. (8388104)
1993
39
Subclinical syringoma coexisting with nevocellular nevus on the vulva. (8478501)
1993
40
Generalised eruptive syringoma--a papular dermatosis. (1965678)
1990
41
Syringoma presenting as milia. (3819065)
1987
42
Multiple penile papules. Syringoma. (3662576)
1987
43
Malignant chondroid syringoma. (2822351)
1987
44
Syringoma of the ankle. (6715599)
1984
45
Chondroid syringoma. (6100183)
1984
46
Syringoma of the forehead. (6840942)
1983
47
Acral syringoma: electron microscopic studies on its origin. (6175141)
1982
48
Chondroid syringoma (mixed tumour) of radius. (6266947)
1981
49
Ultrastructure of chondroid syringoma: role of the myoepithelial cell in the development of the mixed tumor of the skin and soft tissues. (222430)
1979
50
Metastasising chondroid syringoma. (4352760)
1973

Variations for Syringoma

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Expression for genes affiliated with Syringoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Syringoma

Search GEO for disease gene expression data for Syringoma.

Pathways for genes affiliated with Syringoma

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50PathCards, 38NCBI BioSystems Database, 55Reactome, 12EMD Millipore, 60Thomson Reuters, 5Cell Signaling Technology, 53QIAGEN
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Compounds for genes affiliated with Syringoma

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45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 3BitterDB, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Syringoma according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1orcein459.7VIM, S100B, DES
2eosin459.5MUC1, VIM, GFAP, S100B
3progestin459.3MUC1, VIM, ESR1, DES
42-methoxyethanol459.3VIM, S100A1, KRT14
5toluidine459.3S100A1, DES, VIM
6s 100459.2GFAP, DES, VIM, MUC1, S100B
7reticulin459.2MUC1, S100B, DES, VIM, GFAP
8dihydrotestosterone45 29 24 1112.2DES, MUC1, VIM, ESR1
9chloramphenicol45 3 51 1112.0MUC1, ESR1, VIM, S100B, KRT14
10hyaluronic acid45 2410.0VIM, MUC1, DES, KRT19
11methionine458.9KRT14, S100B, VIM, GFAP, DES
12biotin45 24 1110.9KRT1, S100A1, MUC1, VIM, DES
13proline458.8DES, VIM, S100B, KRT14, KRT1
14butyrate458.8KRT19, KRT14, MUC1, VIM, GFAP
15retinoid458.8KRT19, ESR1, KRT1, KRT14, VIM
16paclitaxel45 51 1110.8S100B, VIM, KRT19, ESR1, GFAP
17threonine458.7GFAP, DES, MUC1, KRT14, S100B, KRT1
18acth458.6S100B, CEACAM3, GFAP, MUC1
19acetylcholine45 51 29 24 1112.6S100B, S100A1, VIM, GFAP, DES
20formaldehyde45 249.6S100B, MUC1, VIM, GFAP, KRT19, DES
21cisplatin45 51 61 1111.6GFAP, MUC1, ESR1, KRT19, KRT14
22methotrexate51 45 1110.6MUC1, CEACAM3, VIM, ESR1
23arginine458.6KRT14, DES, GFAP, VIM, S100B, KRT1
24estradiol45 24 1110.6MUC1, KRT19, ESR1, VIM, GFAP, DES
25tamoxifen45 51 29 1111.5KRT14, ESR1, VIM, MUC1, CEACAM3
26cyclic amp45 249.4VIM, MUC1, GFAP, DES, S100B
27adriamycin458.4CEACAM3, KRT19, MUC1, VIM, DES
28bromodeoxyuridine458.3KRT14, VIM, KRT19, KRT1, DES, S100B
29thymidine45 249.2GFAP, S100B, KRT19, CEACAM3, DES, MUC1
30aspartate458.1CEACAM3, VIM, S100B, GFAP, KRT1, KRT19
31steroid458.1S100B, KRT1, ESR1, DES, CEACAM3, KRT19
32lactate458.1CEACAM3, VIM, S100B, KRT19, DES, GFAP
33testosterone45 61 24 1111.0GFAP, VIM, DES, KRT19, KRT1, S100B
34glycogen45 249.0VIM, GFAP, DES, MUC1, S100A1, S100B
35oxygen45 248.9KRT19, CEACAM3, MUC1, GFAP, DES, S100B
36serine457.9MUC1, GFAP, DES, KRT19, VIM, KRT1
37iron45 248.9GFAP, KRT14, DES, S100B, S100A1, VIM
38creatinine457.8DES, GFAP, VIM, MUC1, S100B, CEACAM3
39glucose457.8DES, GFAP, MUC1, S100B, KRT14, KRT19
40mucicarmine457.7CEACAM3, MUC1, VIM, DES, S100B, KRT14
41cysteine457.6DES, GFAP, VIM, S100A1, DAND5, KRT14
42b 723457.5DES, VIM, MUC1, CEACAM3, S100A1, S100B
43vegf457.5CEACAM3, MUC1, VIM, S100B, GFAP, DES
44retinoic acid45 248.0KRT19, KRT1, KRT14, DES, S100B, S100A1
45tyrosine457.0DES, KRT19, GFAP, KRT1, KRT14, S100B
46calcium45 51 24 119.9GFAP, DES, MUC1, CEACAM3, S100A1, S100B
47hematoxylin456.5GFAP, KRT19, KRT1, KRT14, DES, S100B
48paraffin456.2GFAP, DES, ESR1, VIM, KRT19, KRT1
49estrogen456.2DES, GFAP, ESR1, MUC1, CEACAM3, S100A1
50progesterone45 29 61 24 1110.2KRT14, S100B, S100A1, CEACAM3, DES, MUC1

GO Terms for genes affiliated with Syringoma

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16Gene Ontology
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Cellular components related to Syringoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell peripheryGO:0719449.2KRT19, KRT14
2Z discGO:0300188.9DES, S100A1, KRT19
3extracellular vesicular exosomeGO:0700628.5KRT19, KRT1, KRT14, MUC1, VIM
4intermediate filamentGO:0058828.4KRT19, KRT14, VIM, GFAP, DES

Biological processes related to Syringoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1long-term synaptic potentiationGO:0602919.9GFAP, S100B
2Bergmann glial cell differentiationGO:0600209.8VIM, GFAP
3astrocyte developmentGO:0140029.8VIM, GFAP
4intermediate filament organizationGO:0451099.8VIM, GFAP
5muscle filament slidingGO:0300499.6VIM, DES
6negative regulation of neuron projection developmentGO:0109779.6VIM, GFAP
7regulation of heart contractionGO:0080169.2S100A1, DES

Molecular functions related to Syringoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-dependent protein bindingGO:0483069.6S100B, S100A1
2S100 protein bindingGO:0445489.3S100B, S100A1
3structural constituent of cytoskeletonGO:0052008.5KRT19, KRT14, VIM, GFAP, DES
4identical protein bindingGO:0428028.4DES, ESR1, VIM, S100A1, S100B
5protein bindingGO:0055156.8DES, ESR1, VIM, MUC1, S100A1, S100B

Products for genes affiliated with Syringoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Syringoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet