MCID: SYR003
MIFTS: 38

Syringoma malady

Categories: Rare diseases, Cancer diseases, Skin diseases

Aliases & Classifications for Syringoma

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Aliases & Descriptions for Syringoma:

Name: Syringoma 11 47 49 38 13 67
 
Syringoma Nos 11

Classifications:



External Ids:

Disease Ontology11 DOID:2065
MeSH38 D018252
NCIt44 C3761

Summaries for Syringoma

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Wikipedia:70 Syringomas are harmless eccrine sweat duct tumors, typically found clustered on eyelids, although they... more...

MalaCards based summary: Syringoma, also known as syringoma nos, is related to vulvar syringoma and malignant syringoma. An important gene associated with Syringoma is S100B (S100 Calcium Binding Protein B), and among its related pathways are Aurora B signaling and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include skin, salivary gland and bone, and related mouse phenotypes are muscle and behavior/neurological.

Related Diseases for Syringoma

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Diseases in the Syringoma family:

Malignant Syringoma

Diseases related to Syringoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 172)
idRelated DiseaseScoreTop Affiliating Genes
1vulvar syringoma12.0
2malignant syringoma11.9
3chondroid syringoma of the vulva11.7
4syringomas natal teeth oligodontia11.7
5malignant acrospiroma10.8
62q33.1 microdeletion syndrome10.6MUC1, VIM
7distal monosomy 7q3610.5MUC1, VIM
8transitional meningioma10.5MUC1, VIM
9skin sarcoma10.5MUC1, VIM
10hypotonia10.5S100B, VIM
11exstrophy-epispadias complex10.5S100B, VIM
12fraxf syndrome10.5S100B, VIM
13logopenic progressive aphasia10.5MUC1, S100B
14intermediate dend syndrome10.5MUC1, S100B
15ovarian surface papilloma10.5MUC1, VIM
16ovarian cystadenocarcinoma10.5MUC1, VIM
17malignant cystic nephroma10.5S100B, VIM
18relapsing epidemic typhus10.5MUC1, S100B
19pituitary deficiency due to rathke's pouch cysts10.5MUC1, S100B
20penis verrucous carcinoma10.4MUC1, S100B
21serous cystadenocarcinoma10.4MUC1, VIM
22epithelioid cell melanoma10.4S100B, VIM
23primary syphilis10.4MUC1, VIM
24breast papillary carcinoma10.4MUC1, S100B
25pauciarticular onset juvenile idiopathic arthritis10.4S100B, VIM
26osteopetrosis and infantile neuroaxonal dystrophy10.4S100B, VIM
27pediatric meningioma10.4MUC1, VIM
28harding ataxia10.4DES, VIM
29lymphocytic vasculitis10.4DES, VIM
30skin lipoma10.4DES, VIM
31follicular adenoma10.4MUC1, VIM
32pancreatic delta cell neoplasm10.4DES, VIM
33lipoadenoma10.4MUC1, S100B
34anterograde amnesia10.4DES, VIM
35mollaret meningitis10.4DES, VIM
36intravascular fasciitis10.4DES, MUC1
37combined thymoma10.4DES, MUC1
38sporadic idiopathic steroid-resistant nephrotic syndrome with minimal changes10.4MUC1, S100B
39focal chorioretinitis10.4DES, VIM
40malignant glandular tumor of peripheral nerve sheath10.4DES, VIM
41congenital hypogammaglobulinemia10.3GFAP, VIM
42ependymoblastoma10.3GFAP, VIM
43t-cell childhood acute lymphocytic leukemia10.3DES, VIM
44white platelet syndrome10.3DES, MUC1
45bickerstaff brainstem encephalitis10.3DES, S100B
46radio-ulnar synostosis type 110.3DES, MUC1
47nerve root neoplasm10.3MUC1, S100B
48intracystic papillary adenoma10.3GFAP, S100B
49hemiplegia alterans10.3GFAP, S100B
50amelogenesis imperfecta local hypoplastic10.3TP63, VIM

Graphical network of the top 20 diseases related to Syringoma:



Diseases related to syringoma

Symptoms for Syringoma

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Drugs & Therapeutics for Syringoma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Trial of Radiotherapy and Panitumumab in Salivary Gland MalignanciesWithdrawnNCT00984217Phase 2

Search NIH Clinical Center for Syringoma


Cochrane evidence based reviews: syringoma

Genetic Tests for Syringoma

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Anatomical Context for Syringoma

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MalaCards organs/tissues related to Syringoma:

35
Skin, Salivary gland, Bone, Lymph node, Spinal cord

Animal Models for Syringoma or affiliated genes

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MGI Mouse Phenotypes related to Syringoma:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3DES, ESR1, GFAP, TP63, VIM
2MP:00053868.0DES, ESR1, GFAP, S100B, TP63, VIM
3MP:00028737.9ESR1, GFAP, S100B, SERPINB5, TP63
4MP:00053847.9DES, ESR1, GFAP, SERPINB5, TP63, VIM

Publications for Syringoma

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Articles related to Syringoma:

(show top 50)    (show all 357)
idTitleAuthorsYear
1
Dermoscopy of isolated syringoma of the vulva. (28087025)
2017
2
Local recurrence of cutaneous mixed tumor (chondroid syringoma) as malignant mixed tumor of the thumb 20 years after initial diagnosis. (28035707)
2016
3
Dermoscopic features of eruptive milium-like syringoma. (25961748)
2015
4
Chondroid syringoma with extensive bone formation: a case report and review of the literature. (25478357)
2014
5
Chondroid syringoma of the medial canthus. (24744935)
2014
6
Giant chondroid syringoma of the eyelid. (23931483)
2013
7
Facial localization of malignant chondroid syringoma: a rare case report. (23476847)
2013
8
Case for diagnosis. Chondroid syringoma. (24474117)
2013
9
Eruptive milium-like syringoma showing eccrine duct origin of milia. (22150478)
2012
10
Mohs micrographic surgery for recurrent chondroid syringoma of the eyebrow. (22309155)
2012
11
Autosomal dominant multiple syringomas linked to chromosome 16q22. (20132207)
2010
12
Eruptive syringoma associated with hyperthyroidism. (20527152)
2010
13
Milia with calcium deposits on the palms and soles in a patient with multiple syringoma. (20653855)
2010
14
Fine needle aspiration cytology of chondroid syringoma. (20698155)
2010
15
Autoimmune acrosyringitis with ductal cysts: reclassification of case of eruptive syringoma. (19522848)
2009
16
Chondroid syringoma: a rare tumor of orofacial region. (19633639)
2009
17
Eccrine spiradenoma with chondroid syringoma in Blaschkoid distribution. (19915242)
2009
18
Eruptive syringoma developed over a waxing skin area. (18645310)
2008
19
Giant benign chondroid syringoma of the cheek: case report and review of the literature. (17719408)
2007
20
Sonographic and magnetic resonance imaging findings of a chondroid syringoma of the heel: case report and literature review. (17901146)
2007
21
Periorbital syringoma: a pilot study of the efficacy of low-voltage electrocoagulation. (17034373)
2006
22
A rare case of chondroid syringoma arising from the lower eyelid with ectropion. (17051093)
2006
23
Elevated levels of serum carcinoembryonic antigen in a patient with eruptive syringoma. (16112373)
2005
24
Chondroid syringoma. Cytokeratin 20 immunolocalization of Merkel cells and reappraisal of apocrine folliculo-sebaceous differentiation. (15335266)
2004
25
Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma, spiradenoma, and syringoma. (14739501)
2004
26
Localized vulvar syringoma causing vulval pruritus and venerophobia. (15527439)
2004
27
Multiple syringomas in an unusual distribution. (14673269)
2003
28
Adenocarcinoma arising in a chondroid syringoma of vulva. (14501823)
2003
29
Vulvar syringoma causing pruritus and carcinophobia: treatment by argon laser. (11360416)
1999
30
Malignant chondroid syringoma. (9769603)
1998
31
Intrascrotal chondroid syringoma. (9052491)
1997
32
Hyaline cell-rich chondroid syringoma: epithelial nature of the hyaline cells. (8765182)
1996
33
Chondroid syringoma diagnosed by fine-needle aspiration: a case report. (8187595)
1994
34
Chondroid syringoma. A rare occurrence in the hallux. (8394420)
1993
35
Fine needle aspiration cytology of chondroid syringoma and syringocystadenoma papilliferum. A report of two cases. (8392255)
1993
36
Clear cells of eccrine glands in a patient with clear cell syringoma associated with diabetes mellitus. (8494118)
1993
37
Chondroid syringoma. A neglected diagnosis. (1654304)
1991
38
Sclerosing syringoma. (2331127)
1990
39
Fine needle aspiration cytology of chondroid syringoma. Report of a case. (2456654)
1988
40
Pathologic quiz case 1. Chondroid syringoma. (2833291)
1988
41
Multiple penile papules. Syringoma. (3662576)
1987
42
Malignant chondroid syringoma. (2822351)
1987
43
Chondroid syringoma of the upper lip: report of a case. (2427674)
1986
44
Syringoma: removal by electrodesiccation and curettage. (4091468)
1985
45
Acral syringoma: electron microscopic studies on its origin. (6175141)
1982
46
Ultrastructure of chondroid syringoma: role of the myoepithelial cell in the development of the mixed tumor of the skin and soft tissues. (222430)
1979
47
Malignant chondroid syringoma of the thigh. Report of a case with electron microscopy of the tumour. (169339)
1975
48
Metastasising chondroid syringoma. (4352760)
1973
49
Syringoma. Three cases with vulvar involvement. (5008292)
1972
50
Syringocystadenoma papilliferum, nevus sebaceus and basal-cell epithelioma (with features of epithelioma adenoides cysticum and syringoma); their concurrent presence in a single tumor; report of a case. (14901605)
1951

Variations for Syringoma

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Expression for genes affiliated with Syringoma

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Search GEO for disease gene expression data for Syringoma.

Pathways for genes affiliated with Syringoma

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Pathways related to Syringoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.3DES, VIM
29.2GFAP, S100B, VIM
3
Show member pathways
8.9DES, GFAP, VIM
48.7SERPINB5, TP63, VIM

GO Terms for genes affiliated with Syringoma

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Cellular components related to Syringoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament cytoskeletonGO:00451119.4DES, GFAP, VIM
2intermediate filamentGO:00058829.4DES, GFAP, VIM
3nuclear chromatinGO:00007908.8ESR1, MUC1, TP63
4cytoplasmGO:00057376.1DES, ESR1, GFAP, MUC1, S100B, SERPINB5

Biological processes related to Syringoma according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:00600209.9GFAP, VIM
2intermediate filament-based processGO:00451039.9GFAP, VIM
3long-term synaptic potentiationGO:00602919.6GFAP, S100B
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.6MUC1, TP63
5negative regulation of neuron projection developmentGO:00109779.5GFAP, VIM
6epithelial cell developmentGO:00020649.5ESR1, TP63
7regulation of neuron apoptotic processGO:00435239.5ESR1, TP63
8muscle filament slidingGO:00300499.4DES, VIM
9astrocyte developmentGO:00140029.2GFAP, VIM
10intermediate filament organizationGO:00451098.9DES, GFAP, VIM

Molecular functions related to Syringoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052009.1DES, GFAP, VIM
2identical protein bindingGO:00428027.6DES, ESR1, S100B, TP63, VIM

Sources for Syringoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet