MCID: SYR003
MIFTS: 47

Syringoma malady

Summaries for Syringoma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Syringomas are firm yellowish, translucent, or skin colored papules that are often found on the face, particularly around the eyes. they may occur suddenly in crops or multiples. they arise from the sweat ducts. they usually cause no symptoms. they are not associated with underlying abnormality. they are found more commonly in caucasians, and in females at puberty or near middle-age. last updated: 8/6/2009

MalaCards: Syringoma, also known as syringoma nos, is related to malignant syringoma and adenoma. An important gene associated with Syringoma is KRT1 (keratin 1), and among its related pathways are Type I hemidesmosome assembly and Prolactin receptor signaling. The compounds estrogen and ici 164384 have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and bone, and related mouse phenotype integument.

Wikipedia:63 Syringomas are harmless sweat duct tumors, typically found clustered on eyelids, although they may also... more...

Aliases & Classifications for Syringoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

syringoma 8 42 10 44 60
syringoma nos 8


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Disease Ontology8 DOID:2065
NCIt39 C3761
MeSH34 D018252

Related Diseases for Syringoma

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17GeneCards, 18GeneDecks
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Diseases in the Syringoma family:

Malignant Syringoma Multiple Syringomas

Diseases related to Syringoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1malignant syringoma31.0DAND5
2adenoma30.3S100A1, MUC1, KRT19, KRT14, KRT20, CEACAM3
3pleomorphic adenoma30.3S100B, S100A1, DES, MUC1, GFAP, KRT14
4syringocystadenoma papilliferum30.2CLEC2A, PIP
5spiradenoma30.1CLEC2A
6hidrocystoma30.0PIP, SGTA
7basal cell carcinoma30.0PIP, KRT19, KRT20
8keratosis29.8KRT1, CLEC2A
9hidradenoma29.8CLEC2A, MUC1, PIP
10adenoid cystic carcinoma29.8CEACAM3, KRT20, KRT14, KRT19, MUC1, S100A1
11adenocarcinoma29.8PIP, MUC1, PGR, KRT19, KRT5, KRT1
12vulvar syringoma10.5
13diabetes mellitus10.3
14multiple syringomas10.1
15chondroid syringoma of the vulva10.1
16down syndrome10.1
17urticaria pigmentosa10.1
18adenoiditis10.1
19alopecia10.1
20calcinosis10.1
21hyperthyroidism10.1
22urticaria10.1
23syringomas natal teeth oligodontia10.1
24cystadenoma10.0CEACAM3
25gallbladder cancer10.0CEACAM3
26renal oncocytoma10.0S100A1
27leukoplakia10.0KRT1
28thymoma10.0CEACAM3
29clear cell ependymoma10.0MUC1
30choroid plexus papilloma10.0GFAP
31eccrine porocarcinoma10.0MUC1
32colon adenocarcinoma10.0KRT20
33pilomatrixoma10.0CLEC2A
34thyroid cancer10.0KRT19
35craniopharyngioma10.0KRT14
36acanthoma10.0CLEC2A
37osteosarcoma10.0ESR1
38cystadenocarcinoma10.0CEACAM3, MUC1
39cerebral meningioma10.0PGR
40thymus cancer10.0CEACAM3, MUC1
41fibrous meningioma10.0S100B, MUC1
42secretory meningioma10.0MUC1
43nephrogenic adenoma10.0S100A1
44giant cell glioblastoma10.0GFAP
45anaplastic astrocytoma10.0GFAP
46perineurioma10.0S100B, MUC1
47lung cancer10.0MUC1, KRT19
48prion disease10.0GFAP
49langerhans-cell histiocytosis10.0S100A1, S100B
50sertoli-leydig cell tumor10.0PGR, MUC1

Graphical network of the top 20 diseases related to Syringoma:



Diseases related to syringoma

Clinical Features for Syringoma

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Drugs & Therapeutics for Syringoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Syringoma

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Anatomical Context for Syringoma

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32MalaCards
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MalaCards organs/tissues related to Syringoma:

32
Skin, Eye, Bone, Salivary gland, Lymph node, Breast

Animal Models for Syringoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Syringoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.2KRT14, KRT1, KRT5, KRT19, S100B

Publications for Syringoma

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50PubMed
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Articles related to Syringoma:

(show top 50)    (show all 305)
idTitleAuthorsYear
1
Giant chondroid syringoma radiologically mimicking malignancy. (23723512)
2013
2
Pleomorphic adenoma (formerly chondroid syringoma) of the eyelid margin with a pseudocystic appearance. (23294914)
2013
3
Multiple giant vulvar syringoma: an extraordinary report. (24340473)
2013
4
Mohs micrographic surgery for recurrent chondroid syringoma of the eyebrow. (22309155)
2012
5
Seborrheic keratosis coexisting with syringoma. (22565467)
2012
6
An immunohistochemical study of the origin of the solid strand in syringoma, using carcinoembryonic antigen, epithelial membrane antigen, and cytokeratin 5. (22040364)
2012
7
Benign chondroid syringoma of the orbit: a rare cause of exophtalmos. (22400975)
2012
8
Efficacy of N-(3,4-dimethoxycinnamoyl)-anthranilic acid (tranilast) against eruptive syringoma: report of two cases and review of published work. (22724637)
2012
9
Malignant chondroid syringoma: report of a case with lymph node metastasis 12 years after local excision. (21971270)
2011
10
Treatment of syringoma using an ablative 10,600-nm carbon dioxide fractional laser: a prospective analysis of 35 patients. (21414069)
2011
11
Cytologic features of chondroid syringoma in fine needle aspiration biopsies: a report of 3 cases. (20391975)
2010
12
Syringoma treated with pinhole method. (19207646)
2009
13
Eruptive syringoma developed over a waxing skin area. (18645310)
2008
14
Chondroid syringoma. (18301822)
2008
15
Chondroid syringoma of the hand: a rare localization. (18058676)
2007
16
Chondroid syringoma: case report and review of the literature. (16962023)
2006
17
A rare case of atypical chondroid syringoma of the lower eyelid and review of the literature. (16644368)
2006
18
Penile syringoma in a 14-year-old boy. (16709506)
2006
19
Trichostasis spinulosa arising within syringoma. (16335881)
2005
20
Generalized eruptive syringoma. (16191012)
2005
21
The chondroid syringoma: report of a case arising from the external auditory canal. (15739085)
2005
22
Multiple syringomas in an unusual distribution. (14673269)
2003
23
Chondroid syringoma: a diagnosis more frequent than expected. (12562350)
2003
24
Diagnosis of chondroid syringoma by fine needle aspiration cytology. (12789947)
2003
25
Syringoma of the moustache area. (12894094)
2003
26
Chondroid syringoma of the hand. (12564820)
2002
27
Vulvar syringoma causing pruritus and carcinophobia: treatment by argon laser. (11360416)
1999
28
Chondroid syringoma of the orbit. (9972727)
1999
29
Solitary giant vulval syringoma. (10468833)
1999
30
Eruptive syringoma. (20921761)
1998
31
Malignant chondroid syringoma. (9769603)
1998
32
Chondroid syringoma: an immunohistochemical study using antibodies to Ca 15-3, KA-93, Ca 19-9, CD44 and BM-1. (9001983)
1996
33
Malignant chondroid syringoma of scalp with cervical lymph node metastases. (9251433)
1996
34
Vulvar syringoma exacerbated during pregnancy. (8801140)
1996
35
Malignant chondroid syringoma. (8840764)
1996
36
Solitary syringoma. Report of five cases and clinicopathologic comparison with microcystic adnexal carcinoma of the skin. (8599451)
1995
37
Chondroid syringoma diagnosed by fine-needle aspiration: a case report. (8187595)
1994
38
Chondroid syringoma. A neglected diagnosis. (1654304)
1991
39
Primary adenoid cystic carcinoma masquerading as syringoma of the scalp. (2158756)
1990
40
Chondroid syringoma. A review of the literature and case report. (2558165)
1989
41
Fine needle aspiration cytology of chondroid syringoma. Report of a case. (2456654)
1988
42
Familial syringoma. Case history and application of monoclonal anti-eccrine gland antibodies. (3890761)
1985
43
The ultrastructure of chondroid syringoma (mixed tumor of skin). (6205493)
1984
44
Syringoma of the forehead. (6840942)
1983
45
Acral syringoma: electron microscopic studies on its origin. (6175141)
1982
46
Malignant mixed tumor of the skin: malignant chondroid syringoma. (6279274)
1982
47
Chondroid syringoma of skin. (6281338)
1981
48
Syringoma localized to the vulva. (760667)
1979
49
Syringoma. (5307233)
1969
50
Syringoma of the eyelids. (14360900)
1955

Genetic Variations for Syringoma

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Expression for genes affiliated with Syringoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Syringoma

Search GEO for disease gene expression data for Syringoma.

Pathways for genes affiliated with Syringoma

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53Reactome, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Syringoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0KRT14, KRT5
2
Hide members
9.9S100B, PGR, GFAP
3
Hide members
9.7S100B, PGR, GFAP, ESR1
49.6S100B, S100A1, MARCKS
59.4KRT19, KRT5, KRT1, KRT14

Compounds for genes affiliated with Syringoma

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Syringoma according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7GFAP
2ici 1643844410.3ESR1, PGR
3Ethynodiol Diacetate1110.3ESR1, PGR
4Allylestrenol1110.3PGR, ESR1
5eosin4410.3S100B, MUC1, GFAP
6Etonogestrel1110.2PGR, ESR1
7idoxifene4410.2PGR, ESR1
8triphenylethylene4410.1ESR1, PGR
9s 1004410.1S100B, DES, MUC1, GFAP
10reticulin4410.1S100B, DES, MUC1, GFAP
11progestin449.9ESR1, PGR, MUC1, DES
12indium449.8CEACAM3, MUC1
13biotin44 11 2411.8S100A1, DES, MUC1, KRT1
14creatinine449.8CEACAM3, KRT19, GFAP
15streptavidin449.7CEACAM3, KRT20, DES
1612-o-tetradecanoylphorbol 13-acetate449.5DES, MARCKS, MUC1, KRT5, KRT1
17progestins449.5ESR1, PGR, PIP
18glycogen44 2410.5GFAP, MARCKS, CSNK1A1
19paclitaxel44 49 1111.5ESR1, KRT19, GFAP, PGR, S100B
20dihydrotestosterone44 28 11 2412.4PIP, DES, MUC1, PGR, ESR1
21glucose449.4MUC1, GFAP, KRT19, KRT14, CEACAM3
22adriamycin449.4DES, MUC1, PGR, KRT19, CEACAM3
23phospholipid449.4S100B, S100A1, ANXA11, MARCKS, MUC1
24bromodeoxyuridine449.4S100B, DES, GFAP, KRT19, KRT1, KRT14
25proline449.4S100B, DES, KRT5, KRT1, KRT14
26retinoid449.3PGR, KRT19, KRT5, KRT1, KRT14, ESR1
2717beta-hydroxysteroid449.3PGR, KRT19, ESR1
28hyaluronic acid44 2410.3DES, MUC1, KRT19, KRT20
29doxorubicin44 49 1111.2DES, PGR, KRT20, ESR1, CEACAM3
30formaldehyde44 2410.2S100B, DES, MUC1, GFAP, KRT19, KRT20
31thymidine44 2410.2S100B, DES, MUC1, GFAP, KRT19, CEACAM3
32tamoxifen44 49 28 1112.1CEACAM3, ESR1, KRT14, PGR, MUC1, PIP
33aspartate449.0S100B, PGR, GFAP, KRT19, KRT5, KRT1
34alanine449.0S100B, MARCKS, PGR, GFAP, KRT5, KRT14
35steroid448.9PIP, DES, KRT19, KRT1, ESR1, CEACAM3
36estradiol44 11 2410.8PIP, DES, MUC1, PGR, GFAP, KRT19
37iron44 249.8S100B, S100A1, DES, GFAP, KRT19, KRT14
38mucicarmine448.5CEACAM3, KRT20, KRT14, MUC1, S100B, S100A1
39vegf448.4S100B, DES, MUC1, PGR, GFAP, KRT19
40b 723448.2S100B, S100A1, PIP, DES, MUC1, KRT19
41retinoic acid44 249.2MUC1, DES, S100A1, S100B, PGR, GFAP
42threonine448.2S100B, CSNK1A1, DES, MARCKS, MUC1, GFAP
43hematoxylin448.1S100B, S100A1, DES, MUC1, GFAP, KRT19
44cysteine448.0S100B, S100A1, DES, MARCKS, MUC1, PGR
45testosterone44 59 11 2410.8S100B, PIP, DES, MUC1, PGR, GFAP
46serine447.7S100B, CSNK1A1, DES, MARCKS, MUC1, GFAP
47calcium44 49 11 2410.6S100B, S100A1, DES, ANXA11, MARCKS, MUC1
48paraffin446.9S100B, S100A1, PIP, DES, MUC1, PGR
49progesterone44 59 28 11 2410.9DES, MUC1, PGR, GFAP, KRT19, KRT5
50tyrosine446.7MARCKS, DES, CSNK1A1, S100A1, S100B, MUC1

GO Terms for genes affiliated with Syringoma

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16Gene Ontology
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Cellular components related to Syringoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.8KRT14, KRT1, KRT5
2intermediate filamentGO:0058828.4KRT20, KRT14, KRT5, KRT19, GFAP, DES

Biological processes related to Syringoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemidesmosome assemblyGO:03158110.0KRT14, KRT5
2intermediate filament organizationGO:0451099.6KRT20, GFAP

Molecular functions related to Syringoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:0445489.4S100B, S100A1, ANXA11
2structural constituent of cytoskeletonGO:0052008.6KRT20, KRT14, KRT5, KRT19, GFAP, DES
3protein bindingGO:0055155.6S100A1, CSNK1A1, DES, ANXA11, MUC1, CLEC2A

Products for genes affiliated with Syringoma

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Sources for Syringoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet