MCID: SYR003
MIFTS: 37

Syringoma malady

Categories: Rare diseases, Cancer diseases, Skin diseases

Aliases & Classifications for Syringoma

Aliases & Descriptions for Syringoma:

Name: Syringoma 12 50 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2065
MeSH 42 D018252
NCIt 47 C3761
UMLS 69 C0206673

Summaries for Syringoma

NIH Rare Diseases : 50 syringomas are firm yellowish, translucent, or skin colored papules that are often found on the face, particularly around the eyes, but may also appear elsewhere on the face, in the armpits, umbilicus, upper chest, and genitalia. they arise from the sweat ducts and may occur suddenly in crops or multiples. there are 4 types of syringoma: a localized form, a form associated with down syndrome, a generalized form that encompases multiple and eruptive syringomas, and a familial form. syringomas are usually asymptomatic; however, rarely, individuals can experience extreme itching (pruritus), especially while sweating. they are found more commonly in caucasians, and in females at puberty or near middle-age. syringomas may be treated surgically using different methods such as high frequency electric current (electrosurgery) or laser. last updated: 11/14/2016

MalaCards based summary : Syringoma is related to vulvar syringoma and malignant syringoma. An important gene associated with Syringoma is S100B (S100 Calcium Binding Protein B), and among its related pathways/superpathways are Cytoskeletal Signaling and MicroRNAs in cancer. Affiliated tissues include skin, eye and bone, and related phenotype is muscle.

Wikipedia : 71 Syringomas are harmless eccrine sweat duct tumors, typically found clustered on eyelids, although they... more...

Related Diseases for Syringoma

Diseases in the Syringoma family:

Malignant Syringoma

Diseases related to Syringoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 197)
id Related Disease Score Top Affiliating Genes
1 vulvar syringoma 12.0
2 malignant syringoma 11.9
3 chondroid syringoma of the vulva 11.7
4 syringomas natal teeth oligodontia 11.7
5 malignant acrospiroma 10.8
6 immunodeficiency due to a classical component pathway complement deficiency 10.3 MUC1 VIM
7 autosomal recessive stickler syndrome 10.3 MUC1 VIM
8 cervical lymphoepithelioma-like carcinoma 10.3 ESR1 MUC1
9 lupus - neurological sequelae 10.3 S100B VIM
10 avian influenza 10.2 MUC1 VIM
11 benign schwannoma 10.2 S100B VIM
12 vulvar angiokeratoma 10.2 MUC1 VIM
13 jejunal neuroendocrine tumor 10.2 S100B VIM
14 lymphangiosarcoma 10.2 MUC1 VIM
15 poliomyelitis 10.2 ESR1 MUC1
16 progeria 10.2 MUC1 VIM
17 gestational trophoblastic neoplasm 10.2 MUC1 VIM
18 appendix mucinous cystadenocarcinoma 10.2 MUC1 VIM
19 lucey-driscoll syndrome 10.2 MUC1 S100B
20 secondary pulmonary hemosiderosis 10.2 MUC1 S100B
21 chondroblastoma 10.2 MUC1 VIM
22 invasive mole 10.2 MUC1 S100B
23 substance abuse 10.2 ESR1 MUC1
24 subependymal glioma 10.2 MUC1 VIM
25 stomach diverticulosis 10.2 S100B VIM
26 pemphigus vegetans 10.2 MUC1 S100B
27 differentiating neuroblastoma 10.2 MUC1 VIM
28 myxopapillary ependymoma 10.2 GFAP VIM
29 corneal intraepithelial neoplasm 10.2 MUC1 S100B
30 central nervous system mature teratoma 10.2 ESR1 S100B
31 nephrogenic adenoma of urinary bladder 10.2 GFAP VIM
32 adult brainstem gliosarcoma 10.2 GFAP VIM
33 endocardium cancer 10.2 MUC1 S100B
34 precursor t-lymphoblastic lymphoma/leukemia 10.2 MUC1 S100B
35 tumor of exocrine pancreas 10.2 ESR1 MUC1
36 ovarian insufficiency due to fsh resistance 10.2 MUC1 VIM
37 osteochondrodysplasia 10.2 ESR1 S100B
38 onychocytic matricoma 10.2 S100B VIM
39 calcific tendinitis 10.2 GFAP VIM
40 anus adenocarcinoma 10.2 ESR1 MUC1
41 bronchial mucus gland adenoma 10.2 GFAP S100B
42 sclerosing hemangioma 10.2 ESR1 MUC1
43 pulmonary neuroendocrine tumor 10.2 MUC1 S100B
44 aml with myelodysplasia-related features 10.2 TP63 VIM
45 atypical lipomatous tumor 10.2 ESR1 TP63
46 lung clear cell carcinoma 10.2 ESR1 MUC1
47 adenofibroma 10.2 GFAP S100B
48 uterine hypoplasia 10.2 TP63 VIM
49 uterine corpus leiomyomatosis 10.2 MUC1 S100B
50 arthus reaction 10.1 ESR1 GFAP

Graphical network of the top 20 diseases related to Syringoma:



Diseases related to Syringoma

Symptoms & Phenotypes for Syringoma

MGI Mouse Phenotypes related to Syringoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.02 DES ESR1 GFAP TP63 VIM

Drugs & Therapeutics for Syringoma

Interventional clinical trials:


id Name Status NCT ID Phase
1 Trial of Radiotherapy and Panitumumab in Salivary Gland Malignancies Withdrawn NCT00984217 Phase 2

Search NIH Clinical Center for Syringoma

Cochrane evidence based reviews: syringoma

Genetic Tests for Syringoma

Anatomical Context for Syringoma

MalaCards organs/tissues related to Syringoma:

39
Skin, Eye, Bone, Salivary Gland, Breast, Lymph Node, Spinal Cord

Publications for Syringoma

Articles related to Syringoma:

(show top 50) (show all 357)
id Title Authors Year
1
Dermoscopy of isolated syringoma of the vulva. ( 28087025 )
2017
2
Coexistence of Adult Onset Eruptive Syringoma and Bilateral Renal Cell Carcinoma: A Case Report. ( 27922891 )
2017
3
Diagnosis of a rapidly growing preauricular nodule: chondroid syringoma or pleomorphic adenoma? ( 27874890 )
2016
4
Malignant chondroid syringoma in a West African cancer institute: A case report. ( 27372026 )
2016
5
Chondroid Syringoma of the Hypothenar Region. ( 27403399 )
2016
6
Emphasizing the pivotal role of fine-needle aspiration cytology in a case of recurrent malignant chondroid syringoma. ( 27279688 )
2016
7
Syringoma: A clinicopathological study of 244 cases. ( 27112697 )
2016
8
Chondroid syringoma invading the distal phalanx of the thumb: a case report. ( 27090725 )
2016
9
Chondroid syringoma of the axilla: An unusual tumor diagnosed by fine needle aspiration. ( 26800260 )
2016
10
An unusual presentation of chondroid syringoma. ( 27510678 )
2016
11
Chondroid Syringoma: A Case Report in the Foot and Ankle. ( 27587378 )
2016
12
Giant Chondroid Syringoma of the Lower Eyelid. ( 27203613 )
2016
13
Local recurrence of cutaneous mixed tumor (chondroid syringoma) as malignant mixed tumor of the thumb 20 years after initial diagnosis. ( 28035707 )
2016
14
Generalized eruptive syringoma: A clinical dilemma. ( 27057500 )
2016
15
Axillary syringomas misdiagnosed as pseudoxanthoma elasticum for years. ( 26078007 )
2015
16
Chondroid Syringoma: A Case Report. ( 26171105 )
2015
17
Spinal cord compression secondary to metastasis of malignant chondroid syringoma: case report. ( 25555054 )
2015
18
Chondroid Syringoma of the Foot: A Rare Diagnosis. ( 26015300 )
2015
19
Chondroid syringoma of the nasal dorsum. ( 25565228 )
2015
20
Syringoma of vulva: an unusual presentation. Clinical, morphological and immunohistochemical aspects. ( 25920186 )
2015
21
Apocrine Chondroid Syringoma of the Eyelid. ( 26711479 )
2015
22
Chondroid Syringoma of the Philtral Dimple. ( 26865793 )
2015
23
Dermoscopic features of eruptive milium-like syringoma. ( 25961748 )
2015
24
Axillary syringomas mimicking Fox-Fordyce disease. ( 26500884 )
2015
25
Familial eruptive syringoma in a Nigerian girl. ( 26452448 )
2015
26
Extramammary Paget's disease associated with underlying syringoma. ( 26055941 )
2015
27
Generalized eruptive syringoma. ( 25814740 )
2015
28
Eccrine Squamous Syringometaplasia of Underlying Syringoma Associated with Tegafur/Gimeracil/Oteracil (TS-1). ( 25766447 )
2015
29
Chondroid syringoma: report of four cases. ( 26137735 )
2015
30
Treatment of periorbital syringoma by the pinhole method using a carbon dioxide laser in 29 Asian patients. ( 25803568 )
2015
31
Papular Clear Cell Hyperplasia of the Eccrine Duct: A Precursor Lesion of Clear Cell Syringoma? ( 26291420 )
2015
32
Malignant chondroid syringoma of the pinna. ( 26430319 )
2015
33
Eruptive Syringoma in the Elderly: A Case Report. ( 26724882 )
2015
34
Vulvar Syringoma in a Postmenopausal Woman: A Case Report. ( 26592076 )
2015
35
Giant Chondroid Syringoma of the Breast. ( 25919351 )
2015
36
Chondroid syringoma of the medial canthus. ( 24744935 )
2014
37
What is your diagnosis? eruptive syringoma. ( 24505588 )
2014
38
Fine-needle aspiration cytology of chondroid syringoma of fore arm: Report of a rare case. ( 25538390 )
2014
39
Giant benign Chondroid Syringoma in the elbow. ( 25203335 )
2014
40
Erratum to: Benign chondroid syringoma (mixed tumor of skin) on the flank with satellites: case report and literature review. ( 25341655 )
2014
41
An important mimicker: plaque-type syringoma mistakenly diagnosed as microcystic adnexal carcinoma. ( 25111356 )
2014
42
Chondroid syringoma of the ear lobule: a unique case. ( 24817245 )
2014
43
Chondroid syringoma of the forearm: a case report of a rare localization. ( 25284863 )
2014
44
Chondroid syringoma with extensive bone formation: a case report and review of the literature. ( 25478357 )
2014
45
Plaque-like syringoma with involvement of deep reticular dermis. ( 25437993 )
2014
46
Chondroid syringoma with extensive osseous differentiation: a rare finding. ( 24943789 )
2014
47
An unusual case of generalised eruptive syringoma in an adult male. ( 25382918 )
2014
48
Eruptive syringoma localized in intertriginous areas. ( 24393317 )
2014
49
Vulvar syringoma: a rare case report. ( 25302203 )
2014
50
Benign chondroid syringoma (mixed tumor of skin) on the flank with satellites: case report and literature review. ( 25271109 )
2014

Variations for Syringoma

Cosmic variations for Syringoma:

9
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM214343 CYLD skin,face,adnexal tumour,trichoepithelioma c.1327C>T p.Q443* 4
2 COSM476 BRAF skin,abdomen,benign melanocytic nevus,eruptive c.1799T>A p.V600E 4

Expression for Syringoma

Search GEO for disease gene expression data for Syringoma.

Pathways for Syringoma

GO Terms for Syringoma

Cellular components related to Syringoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.33 ESR1 MUC1 TP63
2 intermediate filament cytoskeleton GO:0045111 9.26 DES GFAP
3 cytoplasm GO:0005737 9.23 DES ESR1 GFAP MUC1 S100B SERPINB5
4 intermediate filament GO:0005882 9.13 DES GFAP VIM

Biological processes related to Syringoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 9.26 DES VIM
2 intermediate filament organization GO:0045109 9.16 DES VIM
3 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.96 MUC1 TP63
4 epithelial cell development GO:0002064 8.62 ESR1 TP63

Molecular functions related to Syringoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.13 DES GFAP VIM
2 identical protein binding GO:0042802 9.1 DES ESR1 GFAP S100B TP63 VIM

Sources for Syringoma

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70 UMLS via Orphanet
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