MCID: SYR003
MIFTS: 38

Syringoma malady

Categories: Rare diseases, Cancer diseases, Skin diseases

Aliases & Classifications for Syringoma

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Aliases & Descriptions for Syringoma:

Name: Syringoma 11 48 50 39 13 68
 
Syringoma Nos 11

Classifications:



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Disease Ontology11 DOID:2065
MeSH39 D018252
NCIt45 C3761

Summaries for Syringoma

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NIH Rare Diseases:48 Syringomas are firm yellowish, translucent, or skin colored papules that are often found on the face, particularly around the eyes, but may also appear elsewhere on the face, in the armpits, umbilicus, upper chest, and genitalia. They arise from the sweat ducts and may occur suddenly in crops or multiples. There are 4 types of syringoma: a localized form, a form associated with Down syndrome, a generalized form that encompases multiple and eruptive syringomas, and a familial form. Syringomas are usually asymptomatic; However, rarely, individuals can experience extreme itching (pruritus), especially while sweating. They are found more commonly in Caucasians, and in females at puberty or near middle-age. Syringomas may be treated surgically using different methods such as high frequency electric current (electrosurgery) or laser. Last updated: 11/14/2016

MalaCards based summary: Syringoma, also known as syringoma nos, is related to vulvar syringoma and malignant syringoma. An important gene associated with Syringoma is S100B (S100 Calcium Binding Protein B), and among its related pathways are Aurora B signaling and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include skin, salivary gland and bone, and related mouse phenotypes are muscle and behavior/neurological.

Wikipedia:71 Syringomas are harmless eccrine sweat duct tumors, typically found clustered on eyelids, although they... more...

Related Diseases for Syringoma

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Diseases in the Syringoma family:

Malignant Syringoma

Diseases related to Syringoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 172)
idRelated DiseaseScoreTop Affiliating Genes
1vulvar syringoma12.0
2malignant syringoma11.9
3chondroid syringoma of the vulva11.7
4syringomas natal teeth oligodontia11.7
5malignant acrospiroma10.8
62q33.1 microdeletion syndrome10.6MUC1, VIM
7distal monosomy 7q3610.5MUC1, VIM
8transitional meningioma10.5MUC1, VIM
9skin sarcoma10.5MUC1, VIM
10hypotonia10.5S100B, VIM
11exstrophy-epispadias complex10.5S100B, VIM
12fraxf syndrome10.5S100B, VIM
13logopenic progressive aphasia10.5MUC1, S100B
14intermediate dend syndrome10.5MUC1, S100B
15ovarian surface papilloma10.5MUC1, VIM
16ovarian cystadenocarcinoma10.5MUC1, VIM
17malignant cystic nephroma10.5S100B, VIM
18relapsing epidemic typhus10.5MUC1, S100B
19pituitary deficiency due to rathke's pouch cysts10.5MUC1, S100B
20penis verrucous carcinoma10.4MUC1, S100B
21serous cystadenocarcinoma10.4MUC1, VIM
22epithelioid cell melanoma10.4S100B, VIM
23primary syphilis10.4MUC1, VIM
24breast papillary carcinoma10.4MUC1, S100B
25pauciarticular onset juvenile idiopathic arthritis10.4S100B, VIM
26osteopetrosis and infantile neuroaxonal dystrophy10.4S100B, VIM
27pediatric meningioma10.4MUC1, VIM
28harding ataxia10.4DES, VIM
29lymphocytic vasculitis10.4DES, VIM
30skin lipoma10.4DES, VIM
31follicular adenoma10.4MUC1, VIM
32pancreatic delta cell neoplasm10.4DES, VIM
33lipoadenoma10.4MUC1, S100B
34anterograde amnesia10.4DES, VIM
35mollaret meningitis10.4DES, VIM
36intravascular fasciitis10.4DES, MUC1
37combined thymoma10.4DES, MUC1
38sporadic idiopathic steroid-resistant nephrotic syndrome with minimal changes10.4MUC1, S100B
39focal chorioretinitis10.4DES, VIM
40malignant glandular tumor of peripheral nerve sheath10.4DES, VIM
41congenital hypogammaglobulinemia10.3GFAP, VIM
42ependymoblastoma10.3GFAP, VIM
43t-cell childhood acute lymphocytic leukemia10.3DES, VIM
44white platelet syndrome10.3DES, MUC1
45bickerstaff brainstem encephalitis10.3DES, S100B
46radio-ulnar synostosis type 110.3DES, MUC1
47nerve root neoplasm10.3MUC1, S100B
48intracystic papillary adenoma10.3GFAP, S100B
49hemiplegia alterans10.3GFAP, S100B
50amelogenesis imperfecta local hypoplastic10.3TP63, VIM

Graphical network of the top 20 diseases related to Syringoma:



Diseases related to syringoma

Symptoms & Phenotypes for Syringoma

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MGI Mouse Phenotypes related to Syringoma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3DES, ESR1, GFAP, TP63, VIM
2MP:00053868.0DES, ESR1, GFAP, S100B, TP63, VIM
3MP:00028737.9ESR1, GFAP, S100B, SERPINB5, TP63
4MP:00053847.9DES, ESR1, GFAP, SERPINB5, TP63, VIM

Drugs & Therapeutics for Syringoma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Trial of Radiotherapy and Panitumumab in Salivary Gland MalignanciesWithdrawnNCT00984217Phase 2

Search NIH Clinical Center for Syringoma


Cochrane evidence based reviews: syringoma

Genetic Tests for Syringoma

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Anatomical Context for Syringoma

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MalaCards organs/tissues related to Syringoma:

36
Skin, Salivary gland, Bone, Lymph node, Spinal cord

Publications for Syringoma

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Articles related to Syringoma:

(show top 50)    (show all 356)
idTitleAuthorsYear
1
Dermoscopy of isolated syringoma of the vulva. (28087025)
2017
2
Coexistence of Adult Onset Eruptive Syringoma and Bilateral Renal Cell Carcinoma: A Case Report. (27922891)
2017
3
Local recurrence of cutaneous mixed tumor (chondroid syringoma) as malignant mixed tumor of the thumb 20 years after initial diagnosis. (28035707)
2016
4
Chondroid syringoma of the axilla: An unusual tumor diagnosed by fine needle aspiration. (26800260)
2016
5
Diagnosis of a rapidly growing preauricular nodule: chondroid syringoma or pleomorphic adenoma? (27874890)
2016
6
Chondroid syringoma invading the distal phalanx of the thumb: a case report. (27090725)
2016
7
Emphasizing the pivotal role of fine-needle aspiration cytology in a case of recurrent malignant chondroid syringoma. (27279688)
2016
8
Syringoma: A clinicopathological study of 244 cases. (27112697)
2016
9
Chondroid Syringoma: A Case Report in the Foot and Ankle. (27587378)
2016
10
Generalized eruptive syringoma: A clinical dilemma. (27057500)
2016
11
Giant Chondroid Syringoma of the Lower Eyelid. (27203613)
2016
12
Malignant chondroid syringoma in a West African cancer institute: A case report. (27372026)
2016
13
An unusual presentation of chondroid syringoma. (27510678)
2016
14
Chondroid Syringoma of the Hypothenar Region. (27403399)
2016
15
Dermoscopic features of eruptive milium-like syringoma. (25961748)
2015
16
Spinal cord compression secondary to metastasis of malignant chondroid syringoma: case report. (25555054)
2015
17
Generalized eruptive syringoma. (25814740)
2015
18
Syringoma of vulva: an unusual presentation. Clinical, morphological and immunohistochemical aspects. (25920186)
2015
19
Giant Chondroid Syringoma of the Breast. (25919351)
2015
20
Eruptive Syringoma in the Elderly: A Case Report. (26724882)
2015
21
Axillary syringomas misdiagnosed as pseudoxanthoma elasticum for years. (26078007)
2015
22
Extramammary Paget's disease associated with underlying syringoma. (26055941)
2015
23
Malignant chondroid syringoma of the pinna. (26430319)
2015
24
Vulvar Syringoma in a Postmenopausal Woman: A Case Report. (26592076)
2015
25
Familial eruptive syringoma in a Nigerian girl. (26452448)
2015
26
Axillary syringomas mimicking Fox-Fordyce disease. (26500884)
2015
27
Chondroid Syringoma of the Philtral Dimple. (26865793)
2015
28
Eccrine Squamous Syringometaplasia of Underlying Syringoma Associated with Tegafur/Gimeracil/Oteracil (TS-1). (25766447)
2015
29
Apocrine Chondroid Syringoma of the Eyelid. (26711479)
2015
30
Chondroid Syringoma: A Case Report. (26171105)
2015
31
Chondroid Syringoma of the Foot: A Rare Diagnosis. (26015300)
2015
32
Treatment of periorbital syringoma by the pinhole method using a carbon dioxide laser in 29 Asian patients. (25803568)
2015
33
Chondroid syringoma of the nasal dorsum. (25565228)
2015
34
Papular Clear Cell Hyperplasia of the Eccrine Duct: A Precursor Lesion of Clear Cell Syringoma? (26291420)
2015
35
Chondroid syringoma: report of four cases. (26137735)
2015
36
Chondroid syringoma with extensive bone formation: a case report and review of the literature. (25478357)
2014
37
Chondroid syringoma of the medial canthus. (24744935)
2014
38
Chondroid syringoma-an unusual presentation. (25177574)
2014
39
Vulvar syringoma: a rare case report. (25302203)
2014
40
Eruptive syringoma localized in intertriginous areas. (24393317)
2014
41
Chondroid syringoma. (24605350)
2014
42
An important mimicker: plaque-type syringoma mistakenly diagnosed as microcystic adnexal carcinoma. (25111356)
2014
43
Chondroid syringoma of the ear lobule: a unique case. (24817245)
2014
44
Chondroid syringoma with extensive osseous differentiation: a rare finding. (24943789)
2014
45
Giant benign Chondroid Syringoma in the elbow. (25203335)
2014
46
Fine-needle aspiration cytology of chondroid syringoma of fore arm: Report of a rare case. (25538390)
2014
47
Chondroid syringoma of the forearm: a case report of a rare localization. (25284863)
2014
48
Plaque-like syringoma with involvement of deep reticular dermis. (25437993)
2014
49
What is your diagnosis? eruptive syringoma. (24505588)
2014
50
An unusual case of generalised eruptive syringoma in an adult male. (25382918)
2014

Variations for Syringoma

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Expression for genes affiliated with Syringoma

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Search GEO for disease gene expression data for Syringoma.

Pathways for genes affiliated with Syringoma

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Pathways related to Syringoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.3DES, VIM
29.2GFAP, S100B, VIM
3
Show member pathways
8.9DES, GFAP, VIM
48.7SERPINB5, TP63, VIM

GO Terms for genes affiliated with Syringoma

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Cellular components related to Syringoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.5DES, GFAP, VIM
2intermediate filament cytoskeletonGO:00451119.5DES, GFAP, VIM
3nuclear chromatinGO:00007908.8ESR1, MUC1, TP63
4cytoplasmGO:00057377.0DES, ESR1, GFAP, MUC1, S100B, SERPINB5

Biological processes related to Syringoma according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1long-term synaptic potentiationGO:006029110.2GFAP, S100B
2astrocyte developmentGO:001400210.1GFAP, VIM
3Bergmann glial cell differentiationGO:006002010.1GFAP, VIM
4intermediate filament-based processGO:004510310.1GFAP, VIM
5negative regulation of neuron projection developmentGO:00109779.9GFAP, VIM
6DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.9MUC1, TP63
7muscle filament slidingGO:00300499.8DES, VIM
8epithelial cell developmentGO:00020649.7ESR1, TP63
9intermediate filament organizationGO:00451099.4DES, GFAP, VIM
10regulation of neuron apoptotic processGO:00435239.1ESR1, TP63

Molecular functions related to Syringoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052008.9DES, GFAP, VIM
2identical protein bindingGO:00428028.2DES, ESR1, S100B, TP63, VIM

Sources for Syringoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet