MCID: SYR003
MIFTS: 37

Syringoma malady

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Syringoma

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Aliases & Descriptions for Syringoma:

Name: Syringoma 11 46 13 48 37 66
 
Syringoma Nos 11

Classifications:



External Ids:

Disease Ontology11 DOID:2065
MeSH37 D018252
NCIt43 C3761

Summaries for Syringoma

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NIH Rare Diseases:46 Syringomas are firm yellowish, translucent, or skin colored papules that are often found on the face, particularly around the eyes. they may occur suddenly in crops or multiples. they arise from the sweat ducts. they usually cause no symptoms. they are not associated with underlying abnormality. they are found more commonly in caucasians, and in females at puberty or near middle-age. last updated: 8/6/2009

MalaCards based summary: Syringoma, also known as syringoma nos, is related to vulvar syringoma and malignant syringoma. An important gene associated with Syringoma is SERPINB5 (Serpin Family B Member 5), and among its related pathways are Nuclear signaling by ERBB4 and Aurora B signaling. Affiliated tissues include skin, eye and salivary gland, and related mouse phenotype cellular.

Wikipedia:69 Syringomas are harmless eccrine sweat duct tumors, typically found clustered on eyelids, although they... more...

Related Diseases for Syringoma

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Diseases in the Syringoma family:

Malignant Syringoma

Diseases related to Syringoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1vulvar syringoma12.1
2malignant syringoma12.1
3chondroid syringoma of the vulva11.9
4syringomas natal teeth oligodontia11.9
5malignant acrospiroma10.9
62q33.1 microdeletion syndrome10.7MUC1, VIM
7distal monosomy 7q3610.6MUC1, VIM
8transitional meningioma10.6MUC1, VIM
9congenital structural myopathy10.6MUC1, VIM
10hypotonia10.6S100B, VIM
11skin sarcoma10.6MUC1, VIM
12exstrophy-epispadias complex10.6S100B, VIM
13pineoblastoma10.6MUC1, VIM
14bronchial neoplasm10.6MUC1, VIM
15fraxf syndrome10.6S100B, VIM
16syringoma10.6MUC1, VIM
17logopenic progressive aphasia10.6MUC1, S100B
18intermediate dend syndrome10.6MUC1, S100B
19ovarian surface papilloma10.6MUC1, VIM
20lyme disease - neurological complications10.6MUC1, S100B
21malignant cystic nephroma10.6S100B, VIM
22relapsing epidemic typhus10.6MUC1, S100B
23ovarian cystadenocarcinoma10.6MUC1, VIM
24pituitary deficiency due to rathke's pouch cysts10.5MUC1, S100B
25pseudoglandular variant testicular seminoma10.5MUC1, S100B
26intracranial arteriovenous malformation10.5MUC1, VIM
27external ear disease10.5MUC1, S100B
28pineal parenchymal tumor of intermediate differenciation10.5S100B, VIM
29penis verrucous carcinoma10.5MUC1, S100B
30epithelioid cell melanoma10.5S100B, VIM
31serous cystadenocarcinoma10.5MUC1, VIM
32breast papillary carcinoma10.5MUC1, S100B
33primary syphilis10.5MUC1, VIM
34gorham's disease10.5MUC1, VIM
35glottis verrucous carcinoma10.5ESR1, MUC1
36pauciarticular onset juvenile idiopathic arthritis10.5S100B, VIM
37epicardium cancer10.5MUC1, S100B
38pediatric meningioma10.5MUC1, VIM
39adenocarcinoma in situ10.5ESR1, MUC1
40osteopetrosis and infantile neuroaxonal dystrophy10.5S100B, VIM
41harding ataxia10.5DES, VIM
42lymphocytic vasculitis10.5DES, VIM
43skin lipoma10.5DES, VIM
44follicular adenoma10.5MUC1, VIM
45pancreatic delta cell neoplasm10.5DES, VIM
46anterograde amnesia10.5DES, VIM
47mollaret meningitis10.5DES, VIM
48intravascular fasciitis10.4DES, MUC1
49combined thymoma10.4DES, MUC1
50lipoadenoma10.4MUC1, S100B

Graphical network of the top 20 diseases related to Syringoma:



Diseases related to syringoma

Symptoms for Syringoma

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Drugs & Therapeutics for Syringoma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Trial of Radiotherapy and Panitumumab in Salivary Gland MalignanciesWithdrawnNCT00984217Phase 2

Search NIH Clinical Center for Syringoma


Cochrane evidence based reviews: syringoma

Genetic Tests for Syringoma

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Anatomical Context for Syringoma

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MalaCards organs/tissues related to Syringoma:

34
Skin, Eye, Salivary gland, Bone, Breast, Lymph node, Spinal cord

Animal Models for Syringoma or affiliated genes

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MGI Mouse Phenotypes related to Syringoma:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.2DES, ESR1, KRT14, SERPINB5, TP63, VIM

Publications for Syringoma

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Articles related to Syringoma:

(show top 50)    (show all 352)
idTitleAuthorsYear
1
Dermoscopic features of eruptive milium-like syringoma. (25961748)
2015
2
Chondroid syringoma with extensive bone formation: a case report and review of the literature. (25478357)
2014
3
Chondroid syringoma of the medial canthus. (24744935)
2014
4
Giant chondroid syringoma of the eyelid. (23931483)
2013
5
Facial localization of malignant chondroid syringoma: a rare case report. (23476847)
2013
6
Case for diagnosis. Chondroid syringoma. (24474117)
2013
7
Eruptive milium-like syringoma showing eccrine duct origin of milia. (22150478)
2012
8
Mohs micrographic surgery for recurrent chondroid syringoma of the eyebrow. (22309155)
2012
9
Autosomal dominant multiple syringomas linked to chromosome 16q22. (20132207)
2010
10
Eruptive syringoma associated with hyperthyroidism. (20527152)
2010
11
Milia with calcium deposits on the palms and soles in a patient with multiple syringoma. (20653855)
2010
12
Fine needle aspiration cytology of chondroid syringoma. (20698155)
2010
13
Autoimmune acrosyringitis with ductal cysts: reclassification of case of eruptive syringoma. (19522848)
2009
14
Chondroid syringoma: a rare tumor of orofacial region. (19633639)
2009
15
Eccrine spiradenoma with chondroid syringoma in Blaschkoid distribution. (19915242)
2009
16
Syringoma treated with pinhole method. (19207646)
2009
17
Eruptive syringoma developed over a waxing skin area. (18645310)
2008
18
Giant benign chondroid syringoma of the cheek: case report and review of the literature. (17719408)
2007
19
Sonographic and magnetic resonance imaging findings of a chondroid syringoma of the heel: case report and literature review. (17901146)
2007
20
Periorbital syringoma: a pilot study of the efficacy of low-voltage electrocoagulation. (17034373)
2006
21
A rare case of chondroid syringoma arising from the lower eyelid with ectropion. (17051093)
2006
22
Elevated levels of serum carcinoembryonic antigen in a patient with eruptive syringoma. (16112373)
2005
23
Chondroid syringoma. Cytokeratin 20 immunolocalization of Merkel cells and reappraisal of apocrine folliculo-sebaceous differentiation. (15335266)
2004
24
Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma, spiradenoma, and syringoma. (14739501)
2004
25
Localized vulvar syringoma causing vulval pruritus and venerophobia. (15527439)
2004
26
Multiple syringomas in an unusual distribution. (14673269)
2003
27
Adenocarcinoma arising in a chondroid syringoma of vulva. (14501823)
2003
28
Chondroid syringoma: a diagnosis more frequent than expected. (12562350)
2003
29
Vulvar syringoma causing pruritus and carcinophobia: treatment by argon laser. (11360416)
1999
30
Malignant chondroid syringoma. (9769603)
1998
31
Intrascrotal chondroid syringoma. (9052491)
1997
32
Hyaline cell-rich chondroid syringoma: epithelial nature of the hyaline cells. (8765182)
1996
33
Chondroid syringoma diagnosed by fine-needle aspiration: a case report. (8187595)
1994
34
Chondroid syringoma. A rare occurrence in the hallux. (8394420)
1993
35
Fine needle aspiration cytology of chondroid syringoma and syringocystadenoma papilliferum. A report of two cases. (8392255)
1993
36
Clear cells of eccrine glands in a patient with clear cell syringoma associated with diabetes mellitus. (8494118)
1993
37
Chondroid syringoma. A neglected diagnosis. (1654304)
1991
38
Sclerosing syringoma. (2331127)
1990
39
Fine needle aspiration cytology of chondroid syringoma. Report of a case. (2456654)
1988
40
Pathologic quiz case 1. Chondroid syringoma. (2833291)
1988
41
Multiple penile papules. Syringoma. (3662576)
1987
42
Malignant chondroid syringoma. (2822351)
1987
43
Chondroid syringoma of the upper lip: report of a case. (2427674)
1986
44
Syringoma: removal by electrodesiccation and curettage. (4091468)
1985
45
Acral syringoma: electron microscopic studies on its origin. (6175141)
1982
46
Ultrastructure of chondroid syringoma: role of the myoepithelial cell in the development of the mixed tumor of the skin and soft tissues. (222430)
1979
47
Malignant chondroid syringoma of the thigh. Report of a case with electron microscopy of the tumour. (169339)
1975
48
Metastasising chondroid syringoma. (4352760)
1973
49
Syringoma. Three cases with vulvar involvement. (5008292)
1972
50
Syringocystadenoma papilliferum, nevus sebaceus and basal-cell epithelioma (with features of epithelioma adenoides cysticum and syringoma); their concurrent presence in a single tumor; report of a case. (14901605)
1951

Variations for Syringoma

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Cosmic variations for Syringoma:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1COSM214343CYLDskin,face,adnexal tumour,trichoepitheliomac.1327C>Tp.Q443*0

Expression for genes affiliated with Syringoma

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Search GEO for disease gene expression data for Syringoma.

Pathways for genes affiliated with Syringoma

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Pathways related to Syringoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.6ESR1, S100B
2
Show member pathways
9.4DES, VIM
3
Show member pathways
8.9DES, KRT14, VIM
48.9SERPINB5, TP63, VIM

GO Terms for genes affiliated with Syringoma

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Cellular components related to Syringoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament cytoskeletonGO:004511110.0DES, VIM
2intermediate filamentGO:00058829.5DES, KRT14, VIM
3nuclear chromatinGO:00007909.1ESR1, MUC1, TP63
4cytoplasmGO:00057376.4DES, ESR1, KRT14, MUC1, S100B, SERPINB5

Biological processes related to Syringoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.5MUC1, TP63
2intermediate filament organizationGO:00451099.5DES, VIM
3regulation of neuron apoptotic processGO:00435239.5ESR1, TP63
4muscle filament slidingGO:00300499.4DES, VIM
5epithelial cell developmentGO:00020649.4ESR1, TP63
6epithelial cell differentiationGO:00308558.7KRT14, MUC1, TP63

Molecular functions related to Syringoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filament bindingGO:199025410.1KRT14, VIM
2structural constituent of cytoskeletonGO:00052009.1DES, KRT14, VIM
3identical protein bindingGO:00428027.7DES, ESR1, S100B, TP63, VIM

Sources for Syringoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet