MCID: SYR003
MIFTS: 47

Syringoma malady

Summaries for Syringoma

About this section
Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Syringomas are firm yellowish, translucent, or skin colored papules that are often found on the face, particularly around the eyes. they may occur suddenly in crops or multiples. they arise from the sweat ducts. they usually cause no symptoms. they are not associated with underlying abnormality. they are found more commonly in caucasians, and in females at puberty or near middle-age. last updated: 8/6/2009

MalaCards: Syringoma, also known as syringoma nos, is related to malignant syringoma and adenoma. An important gene associated with Syringoma is KRT1 (keratin 1), and among its related pathways are Type I hemidesmosome assembly and Prolactin receptor signaling. The compounds estrogen and Ethynodiol Diacetate have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and bone, and related mouse phenotype integument.

Wikipedia:63 Syringomas are harmless sweat duct tumors, typically found clustered on eyelids, although they may also... more...

Aliases & Classifications for Syringoma

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
See all sources

Aliases & Descriptions:

syringoma 8 42 10 44 60
syringoma nos 8


External Ids:

Disease Ontology8 DOID:2065
NCIt39 C3761
MeSH34 D018252

Related Diseases for Syringoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Syringoma family:

Malignant Syringoma Multiple Syringomas

Diseases related to Syringoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1malignant syringoma31.0DAND5
2adenoma30.3S100A1, MUC1, KRT19, KRT14, KRT20, CEACAM3
3pleomorphic adenoma30.3S100B, S100A1, DES, MUC1, GFAP, KRT14
4syringocystadenoma papilliferum30.2CLEC2A, PIP
5spiradenoma30.1CLEC2A
6hidrocystoma30.0PIP, SGTA
7basal cell carcinoma30.0PIP, KRT19, KRT20
8keratosis29.8KRT1, CLEC2A
9hidradenoma29.8CLEC2A, MUC1, PIP
10adenoid cystic carcinoma29.8CEACAM3, KRT20, KRT14, KRT19, MUC1, S100A1
11adenocarcinoma29.8PIP, MUC1, PGR, KRT19, KRT5, KRT1
12vulvar syringoma10.5
13diabetes mellitus10.3
14multiple syringomas10.1
15chondroid syringoma of the vulva10.1
16down syndrome10.1
17urticaria pigmentosa10.1
18adenoiditis10.1
19alopecia10.1
20calcinosis10.1
21hyperthyroidism10.1
22urticaria10.1
23syringomas natal teeth oligodontia10.1
24cystadenoma10.0CEACAM3
25gallbladder cancer10.0CEACAM3
26renal oncocytoma10.0S100A1
27leukoplakia10.0KRT1
28thymoma10.0CEACAM3
29clear cell ependymoma10.0MUC1
30choroid plexus papilloma10.0GFAP
31eccrine porocarcinoma10.0MUC1
32colon adenocarcinoma10.0KRT20
33pilomatrixoma10.0CLEC2A
34thyroid cancer10.0KRT19
35craniopharyngioma10.0KRT14
36acanthoma10.0CLEC2A
37osteosarcoma10.0ESR1
38cystadenocarcinoma10.0CEACAM3, MUC1
39cerebral meningioma10.0PGR
40thymus cancer10.0CEACAM3, MUC1
41fibrous meningioma10.0S100B, MUC1
42secretory meningioma10.0MUC1
43nephrogenic adenoma10.0S100A1
44giant cell glioblastoma10.0GFAP
45anaplastic astrocytoma10.0GFAP
46perineurioma10.0S100B, MUC1
47lung cancer10.0MUC1, KRT19
48prion disease10.0GFAP
49langerhans-cell histiocytosis10.0S100A1, S100B
50sertoli-leydig cell tumor10.0PGR, MUC1

Graphical network of the top 20 diseases related to Syringoma:



Diseases related to syringoma

Clinical Features for Syringoma

About this section

Drugs & Therapeutics for Syringoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Syringoma

Drug clinical trials:

Search ClinicalTrials for Syringoma

Search NIH Clinical Center for Syringoma

Search CenterWatch for Syringoma

Genetic Tests for Syringoma

About this section

Anatomical Context for Syringoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Syringoma:

32
Skin, Eye, Bone, Salivary gland, Lymph node, Breast

Animal Models for Syringoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Syringoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.2KRT14, KRT1, KRT5, KRT19, S100B

Publications for Syringoma

About this section
Sources:
50PubMed
See all sources

Articles related to Syringoma:

(show top 50)    (show all 305)
idTitleAuthorsYear
1
Eruptive syringoma localized in intertriginous areas. (24393317)
2014
2
A curious serendipitous finding: Spitz naevus combined with a syringoma. (22671019)
2013
3
Penile syringoma: reports and review of patients with syringoma located on the penis. (23882308)
2013
4
Finger chondroid syringoma as a hypoechoic subcutaneous nodule in ultrasound. (23945489)
2013
5
Malignant chondroid syringoma of the face with bone invasion. (23095341)
2013
6
Eruptive milium-like syringoma showing eccrine duct origin of milia. (22150478)
2012
7
Chondroid syringoma: a diagnosis by fine needle aspiration cytology. (23112529)
2012
8
Vulval Syringoma: First report of a case in an Egyptian female. (23130299)
2012
9
Chondroid syringoma of the scalp: case report and discussion of clinical features, histopathology, and treatment. (21500172)
2011
10
Fine needle aspiration cytology of chondroid syringoma. (20698155)
2010
11
Chondroid syringoma: a rare tumor of the chest wall. (20172178)
2010
12
Preoperative cytologic diagnosis of chondroid syringoma. (19798896)
2009
13
Eccrine spiradenoma with chondroid syringoma in Blaschkoid distribution. (19915242)
2009
14
Giant facial chondroid syringoma. (19215274)
2009
15
Disseminated form of syringoma (eruptive syringoma) sparing the face-a rare presentation causing diagnostic challenge. (19271392)
2008
16
Chondroid syringoma in a child. (17958797)
2007
17
Clear cell syringoma--association with diabetes mellitus. (16761750)
2005
18
Basal cell carcinoma adjacent to syringoma in periorbital skin: a case report. (16121064)
2005
19
Chondroid syringoma of the upper lip: a case report. (16027488)
2004
20
An unusual chondroid syringoma. (12930345)
2003
21
Chondroid syringoma. A case report. (12038117)
2002
22
Recurrent malignant chondroid syringoma of the foot: a case report and review of the literature. (10857882)
2000
23
Guess what! Clear cell syringoma. (11125330)
2000
24
Syringoma resembling confluent and reticulated papillomatosis of Gougerot-Carteaud. (9564597)
1998
25
Quiz. Syringoma. (9369635)
1997
26
Pleomorphic adenoma of skin (chondroid syringoma) involving the eyelid. (9715316)
1996
27
Chondroid syringoma of the scrotum. (8959533)
1996
28
Hyaline-cell rich chondroid syringoma. A tumor mimicking malignancy. (7541966)
1995
29
Chondroid syringoma. A rare occurrence in the hallux. (8394420)
1993
30
Clear cells of eccrine glands in a patient with clear cell syringoma associated with diabetes mellitus. (8494118)
1993
31
Eruptive syringoma in a Chinese boy. (8444534)
1993
32
Chondroid syringoma with hyaline cell change. (7684353)
1993
33
Atypical chondroid syringoma. (1652102)
1991
34
Sclerosing syringoma. (2331127)
1990
35
Disseminated syringomas of the upper extremities. Case history and immunohistochemical and ultrastructural study. (1694147)
1990
36
Chondroid syringoma associated with hidrocystoma-like changes. Possible differentiation into eccrine gland. A histologic, immunohistochemical and electron microscopic study. (2556458)
1989
37
Malignant chondroid syringoma. (2822351)
1987
38
Chondroid syringoma. (2822820)
1987
39
Chondroid syringoma (mixed tumor of the skin). A clinicopathological study of 13 cases. (2441570)
1987
40
Fulminant metastasizing chondroid syringoma of the skin. (3021016)
1986
41
Response of multiple syringomas to isotretinoin. (2424215)
1986
42
Malignant chondroid syringoma. Report of a case with widespread metastasis and review of pertinent literature. (6194872)
1983
43
Chondroid syringoma in a toe. (6293770)
1982
44
Unilateral linear nevoidal syringoma. (7229146)
1981
45
Syringoma limited to genitalia of a preadolescent girl. (7035516)
1981
46
Ultrastructure of chondroid syringoma: role of the myoepithelial cell in the development of the mixed tumor of the skin and soft tissues. (222430)
1979
47
Malignant chondroid syringoma of the thigh. Report of a case with electron microscopy of the tumour. (169339)
1975
48
Syringoma. Three cases with vulvar involvement. (5008292)
1972
49
Chondroid syringoma. (4341139)
1972
50
Syringoma of the vulva. (5580288)
1971

Genetic Variations for Syringoma

About this section

Expression for genes affiliated with Syringoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Syringoma

Search GEO for disease gene expression data for Syringoma.

Pathways for genes affiliated with Syringoma

About this section
Sources:
53Reactome, 4Cell Signaling Technology, 12EMD Millipore
See all sources

Pathways related to Syringoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0KRT14, KRT5
2
Hide members
9.9GFAP, PGR, S100B
3
Hide members
9.7S100B, PGR, GFAP, ESR1
49.6MARCKS, S100A1, S100B
59.4KRT14, KRT1, KRT5, KRT19

Compounds for genes affiliated with Syringoma

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
See all sources

Compounds related to Syringoma according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7GFAP
2Ethynodiol Diacetate1110.3PGR, ESR1
3ici 1643844410.3ESR1, PGR
4idoxifene4410.3PGR, ESR1
5eosin4410.3MUC1, S100B, GFAP
6Etonogestrel1110.2ESR1, PGR
7Allylestrenol1110.2ESR1, PGR
8triphenylethylene4410.1ESR1, PGR
9s 1004410.1MUC1, DES, S100B, GFAP
10reticulin4410.1GFAP, MUC1, DES, S100B
11progestin449.9PGR, DES, MUC1, ESR1
12indium449.8CEACAM3, MUC1
13biotin44 11 2411.8S100A1, DES, MUC1, KRT1
14creatinine449.8CEACAM3, KRT19, GFAP
15streptavidin449.7DES, CEACAM3, KRT20
1612-o-tetradecanoylphorbol 13-acetate449.5KRT5, KRT1, MARCKS, MUC1, DES
17progestins449.5ESR1, PGR, PIP
18glycogen44 2410.5MARCKS, GFAP, CSNK1A1
19paclitaxel44 49 1111.5S100B, PGR, GFAP, KRT19, ESR1
20dihydrotestosterone44 28 11 2412.4PIP, DES, PGR, MUC1, ESR1
21glucose449.4GFAP, KRT19, CEACAM3, KRT14, MUC1
22adriamycin449.4MUC1, KRT19, CEACAM3, DES, PGR
23phospholipid449.4S100A1, S100B, ANXA11, MARCKS, MUC1
24bromodeoxyuridine449.4DES, GFAP, KRT19, S100B, KRT1, KRT14
25proline449.4KRT5, KRT1, S100B, DES, KRT14
26retinoid449.3KRT1, PGR, KRT14, ESR1, KRT19, KRT5
2717beta-hydroxysteroid449.3PGR, ESR1, KRT19
28hyaluronic acid44 2410.3KRT20, KRT19, DES, MUC1
29doxorubicin44 49 1111.2KRT20, DES, PGR, CEACAM3, ESR1
30formaldehyde44 2410.2GFAP, KRT19, KRT20, DES, S100B, MUC1
31thymidine44 2410.2DES, MUC1, S100B, GFAP, KRT19, CEACAM3
32tamoxifen44 49 28 1112.1MUC1, PGR, CEACAM3, ESR1, PIP, KRT14
33aspartate449.0KRT5, S100B, KRT19, GFAP, PGR, CEACAM3
34alanine449.0KRT5, PGR, GFAP, CEACAM3, KRT14, S100B
35steroid448.9KRT1, ESR1, CEACAM3, DES, KRT19, PIP
36estradiol44 11 2410.8ESR1, KRT19, GFAP, PGR, MUC1, DES
37iron44 249.8DES, GFAP, KRT19, KRT14, KRT20, S100A1
38mucicarmine448.5KRT20, MUC1, DES, PIP, S100A1, KRT14
39vegf448.4DES, CEACAM3, ESR1, KRT20, S100B, KRT19
40b 723448.2CEACAM3, PIP, S100A1, S100B, KRT19, MUC1
41retinoic acid44 249.2KRT1, KRT19, KRT5, DES, KRT14, ESR1
42threonine448.2S100B, GFAP, KRT5, KRT1, KRT14, MUC1
43hematoxylin448.1CEACAM3, KRT14, KRT1, KRT19, GFAP, MUC1
44cysteine448.0DAND5, S100B, SGTA, GFAP, KRT14, PGR
45testosterone44 59 11 2410.8DES, MUC1, PGR, S100B, GFAP, KRT19
46serine447.7CSNK1A1, DES, MUC1, S100B, KRT19, KRT14
47calcium44 49 11 2410.6S100B, DES, KRT5, KRT14, CEACAM3, KRT19
48progesterone44 59 28 11 2411.0GFAP, KRT19, KRT5, KRT1, KRT14, KRT20
49paraffin446.9S100B, KRT1, KRT14, KRT20, CEACAM3, ESR1
50tyrosine446.7MUC1, GFAP, KRT5, CEACAM3, KRT1, KRT14

GO Terms for genes affiliated with Syringoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Syringoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.8KRT14, KRT1, KRT5
2intermediate filamentGO:0058828.4KRT20, KRT14, KRT5, KRT19, GFAP, DES

Biological processes related to Syringoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemidesmosome assemblyGO:03158110.0KRT14, KRT5
2intermediate filament organizationGO:0451099.6KRT20, GFAP

Molecular functions related to Syringoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:0445489.4S100B, S100A1, ANXA11
2structural constituent of cytoskeletonGO:0052008.6KRT20, KRT14, KRT5, KRT19, GFAP, DES
3protein bindingGO:0055155.6S100A1, CSNK1A1, DES, ANXA11, MUC1, CLEC2A

Products for genes affiliated with Syringoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Syringoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet