MCID: SYR003
MIFTS: 38

Syringoma

Categories: Rare diseases, Cancer diseases, Skin diseases

Aliases & Classifications for Syringoma

MalaCards integrated aliases for Syringoma:

Name: Syringoma 12 50 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2065
MeSH 42 D018252
NCIt 47 C3761
UMLS 69 C0206673

Summaries for Syringoma

NIH Rare Diseases : 50 syringomas are firm yellowish, translucent, or skin colored papules that are often found on the face, particularly around the eyes, but may also appear elsewhere on the face, in the armpits, umbilicus, upper chest, and genitalia. they arise from the sweat ducts and may occur suddenly in crops or multiples. there are 4 types of syringoma: a localized form, a form associated with down syndrome, a generalized form that encompases multiple and eruptive syringomas, and a familial form. syringomas are usually asymptomatic; however, rarely, individuals can experience extreme itching (pruritus), especially while sweating. they are found more commonly in caucasians, and in females at puberty or near middle-age. syringomas may be treated surgically using different methods such as high frequency electric current (electrosurgery) or laser. last updated: 11/14/2016

MalaCards based summary : Syringoma is related to vulvar syringoma and malignant syringoma. An important gene associated with Syringoma is S100B (S100 Calcium Binding Protein B), and among its related pathways/superpathways are Cytoskeletal Signaling and MicroRNAs in cancer. Affiliated tissues include skin, eye and salivary gland, and related phenotypes are behavior/neurological and muscle

Wikipedia : 72 Syringomas are harmless eccrine sweat duct tumors, typically found clustered on eyelids, although they... more...

Related Diseases for Syringoma

Diseases in the Syringoma family:

Malignant Syringoma

Diseases related to Syringoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 208)
id Related Disease Score Top Affiliating Genes
1 vulvar syringoma 11.9
2 malignant syringoma 11.9
3 chondroid syringoma of the vulva 11.7
4 syringomas natal teeth oligodontia 11.7
5 malignant acrospiroma 10.8
6 2q31.1 microdeletion syndrome 10.7 MUC1 VIM
7 myeloid/lymphoid neoplasm associated with pdgfra rearrangement 10.7 MUC1 VIM
8 vulvar angiokeratoma 10.6 MUC1 VIM
9 immune-mediated encephalomyelitis 10.6 S100B VIM
10 lymphangiosarcoma 10.6 MUC1 VIM
11 benallegue lacete syndrome 10.6 S100B VIM
12 persian gulf syndrome 10.6 MUC1 VIM
13 diffuse meningeal melanocytosis 10.6 MUC1 VIM
14 neurogenic thoracic outlet syndrome 10.6 S100B VIM
15 ovary papillary carcinoma 10.6 MUC1 VIM
16 logopenic progressive aphasia 10.6 MUC1 S100B
17 heiner syndrome 10.6 MUC1 S100B
18 pancreatic serous cystadenoma 10.6 MUC1 VIM
19 dedifferentiated liposarcoma 10.6 MUC1 S100B
20 ovarian mucinous adenocarcinoma 10.6 MUC1 VIM
21 pancreatic ductal carcinoma 10.6 MUC1 VIM
22 secondary syphilis 10.6 MUC1 VIM
23 simple cryoglobulinemia 10.6 MUC1 S100B
24 spastic ataxia 3 10.6 MUC1 VIM
25 enteric pattern testicular yolk sac tumor 10.6 MUC1 S100B
26 malignant breast melanoma 10.6 S100B VIM
27 gastric papillary adenocarcinoma 10.6 MUC1 S100B
28 oligomeganephronic renal hypoplasia 10.5 S100B VIM
29 infantile scoliosis 10.5 DES VIM
30 aortic aneurysm 10.5 DES VIM
31 lymphocytic infiltrate of jessner 10.5 DES VIM
32 kidney benign neoplasm 10.5 MUC1 VIM
33 strabismus 10.5 MUC1 S100B
34 phobic disorder 10.5 MUC1 S100B
35 skin lipoma 10.5 DES VIM
36 pineal region yolk sac tumor 10.5 DES VIM
37 basosquamous carcinoma 10.5 GFAP VIM
38 mitochondrial myopathy with lactic acidosis 10.5 MUC1 VIM
39 uniparental disomy of chromosome 11 10.5 DES VIM
40 myxoid leiomyosarcoma 10.5 DES VIM
41 berk-tabatznik syndrome 10.5 DES VIM
42 dendritic cell thymoma 10.5 DES MUC1
43 mediastinal osteogenic sarcoma 10.5 MUC1 VIM
44 aggressive systemic mastocytosis 10.5 GFAP VIM
45 axonal neuropathy 10.5 GFAP VIM
46 microcystic meningioma 10.5 MUC1 VIM
47 follicular infundibulum tumor 10.5 DES VIM
48 behcet's syndrome arthropathy 10.5 GFAP VIM
49 epicardium cancer 10.5 MUC1 S100B
50 spleen cancer 10.4 DES S100B

Graphical network of the top 20 diseases related to Syringoma:



Diseases related to Syringoma

Symptoms & Phenotypes for Syringoma

MGI Mouse Phenotypes related to Syringoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.43 DES ESR1 GFAP S100B TP63 VIM
2 muscle MP:0005369 9.02 DES ESR1 GFAP TP63 VIM

Drugs & Therapeutics for Syringoma

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Trial of Radiotherapy and Panitumumab in Salivary Gland Malignancies Withdrawn NCT00984217 Phase 2 Panitumumab

Search NIH Clinical Center for Syringoma

Cochrane evidence based reviews: syringoma

Genetic Tests for Syringoma

Anatomical Context for Syringoma

MalaCards organs/tissues related to Syringoma:

39
Skin, Eye, Salivary Gland, Bone, Lymph Node, Spinal Cord, Lung

Publications for Syringoma

Articles related to Syringoma:

(show top 50) (show all 365)
id Title Authors Year
1
A Case of Eruptive Syringoma Mimicking Plane Warts. ( 28761852 )
2017
2
Case of chondroid syringoma mimicking as nodular hidradenoma: A diagnostic pitfall on cytopathology. ( 28772003 )
2017
3
A case of milium-like syringoma limited to the neck. ( 28449287 )
2017
4
Chondroid Syringoma: Fine-needle Aspiration Cytology of a Rare Entity at an Unusual Site. ( 28892909 )
2017
5
Coexistence of Adult Onset Eruptive Syringoma and Bilateral Renal Cell Carcinoma: A Case Report. ( 27922891 )
2017
6
Generalized eruptive syringoma with poor clinical response to systemic treatment with acitretin. ( 28177590 )
2017
7
Dermoscopy of isolated syringoma of the vulva. ( 28087025 )
2017
8
Chondroid Syringoma of a Cheek. ( 28582289 )
2017
9
Malignant chondroid syringoma of thigh with late metastasis to lung: A very rare case report. ( 28937387 )
2017
10
A rare association in Down syndrome: milialike idiopathic calcinosis cutis and palpebral syringoma. ( 28099543 )
2016
11
Generalized eruptive syringoma: A clinical dilemma. ( 27057500 )
2016
12
Chondroid Syringoma of the Hypothenar Region. ( 27403399 )
2016
13
An unusual presentation of chondroid syringoma. ( 27510678 )
2016
14
Malignant chondroid syringoma in a West African cancer institute: A case report. ( 27372026 )
2016
15
Diagnosis of a rapidly growing preauricular nodule: chondroid syringoma or pleomorphic adenoma? ( 27874890 )
2016
16
Chondroid Syringoma on Face. ( 28913278 )
2016
17
Local recurrence of cutaneous mixed tumor (chondroid syringoma) as malignant mixed tumor of the thumb 20 years after initial diagnosis. ( 28035707 )
2016
18
Syringoma: A clinicopathological study of 244 cases. ( 27112697 )
2016
19
Giant Chondroid Syringoma of the Lower Eyelid. ( 27203613 )
2016
20
Emphasizing the pivotal role of fine-needle aspiration cytology in a case of recurrent malignant chondroid syringoma. ( 27279688 )
2016
21
Chondroid syringoma of the axilla: An unusual tumor diagnosed by fine needle aspiration. ( 26800260 )
2016
22
Chondroid Syringoma: A Case Report in the Foot and Ankle. ( 27587378 )
2016
23
Chondroid syringoma invading the distal phalanx of the thumb: a case report. ( 27090725 )
2016
24
Dermoscopic features of eruptive milium-like syringoma. ( 25961748 )
2015
25
Papular Clear Cell Hyperplasia of the Eccrine Duct: A Precursor Lesion of Clear Cell Syringoma? ( 26291420 )
2015
26
Extramammary Paget's disease associated with underlying syringoma. ( 26055941 )
2015
27
Chondroid Syringoma of the Philtral Dimple. ( 26865793 )
2015
28
Axillary syringomas misdiagnosed as pseudoxanthoma elasticum for years. ( 26078007 )
2015
29
Eccrine Squamous Syringometaplasia of Underlying Syringoma Associated with Tegafur/Gimeracil/Oteracil (TS-1). ( 25766447 )
2015
30
Eruptive Syringoma in the Elderly: A Case Report. ( 26724882 )
2015
31
Malignant chondroid syringoma of the pinna. ( 26430319 )
2015
32
Spinal cord compression secondary to metastasis of malignant chondroid syringoma: case report. ( 25555054 )
2015
33
Chondroid syringoma of the nasal dorsum. ( 25565228 )
2015
34
Generalized eruptive syringoma. ( 25814740 )
2015
35
Axillary syringomas mimicking Fox-Fordyce disease. ( 26500884 )
2015
36
Giant Chondroid Syringoma of the Breast. ( 25919351 )
2015
37
Syringoma of vulva: an unusual presentation. Clinical, morphological and immunohistochemical aspects. ( 25920186 )
2015
38
Chondroid syringoma: report of four cases. ( 26137735 )
2015
39
Familial eruptive syringoma in a Nigerian girl. ( 26452448 )
2015
40
Chondroid Syringoma: A Case Report. ( 26171105 )
2015
41
Chondroid Syringoma of the Foot: A Rare Diagnosis. ( 26015300 )
2015
42
Treatment of periorbital syringoma by the pinhole method using a carbon dioxide laser in 29 Asian patients. ( 25803568 )
2015
43
Apocrine Chondroid Syringoma of the Eyelid. ( 26711479 )
2015
44
Vulvar Syringoma in a Postmenopausal Woman: A Case Report. ( 26592076 )
2015
45
Chondroid syringoma with extensive bone formation: a case report and review of the literature. ( 25478357 )
2014
46
Chondroid syringoma of the medial canthus. ( 24744935 )
2014
47
Chondroid syringoma with extensive osseous differentiation: a rare finding. ( 24943789 )
2014
48
An important mimicker: plaque-type syringoma mistakenly diagnosed as microcystic adnexal carcinoma. ( 25111356 )
2014
49
Chondroid syringoma of the ear lobule: a unique case. ( 24817245 )
2014
50
Eruptive syringoma localized in intertriginous areas. ( 24393317 )
2014

Variations for Syringoma

Cosmic variations for Syringoma:

9
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM476 BRAF skin,abdomen,benign melanocytic nevus,eruptive c.1799T>A p.V600E 4

Expression for Syringoma

Search GEO for disease gene expression data for Syringoma.

Pathways for Syringoma

GO Terms for Syringoma

Cellular components related to Syringoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.33 ESR1 MUC1 TP63
2 intermediate filament cytoskeleton GO:0045111 9.26 DES GFAP
3 cytoplasm GO:0005737 9.23 DES ESR1 GFAP MUC1 S100B SERPINB5
4 intermediate filament GO:0005882 9.13 DES GFAP VIM

Biological processes related to Syringoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 9.4 DES VIM
2 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.32 MUC1 TP63
3 epithelial cell development GO:0002064 9.26 ESR1 TP63
4 long-term synaptic potentiation GO:0060291 9.13 S100B
5 astrocyte development GO:0014002 9.07 VIM
6 Bergmann glial cell differentiation GO:0060020 8.85 VIM
7 intermediate filament-based process GO:0045103 8.65 VIM
8 intermediate filament organization GO:0045109 8.62 DES VIM

Molecular functions related to Syringoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.13 DES GFAP VIM
2 identical protein binding GO:0042802 9.1 DES ESR1 GFAP S100B TP63 VIM

Sources for Syringoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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36 IUPHAR
37 KEGG
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40 MedGen
42 MeSH
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44 MGI
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48 NDF-RT
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55 OMIM via Orphanet
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60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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