MCID: SYR003
MIFTS: 37

Syringoma malady

Categories: Rare diseases, Cancer diseases, Skin diseases

Aliases & Classifications for Syringoma

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Aliases & Descriptions for Syringoma:

Name: Syringoma 11 48 50 39 13 68

Classifications:



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Disease Ontology11 DOID:2065
MeSH39 D018252
NCIt45 C3761

Summaries for Syringoma

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NIH Rare Diseases:48 Syringomas are firm yellowish, translucent, or skin colored papules that are often found on the face, particularly around the eyes, but may also appear elsewhere on the face, in the armpits, umbilicus, upper chest, and genitalia. they arise from the sweat ducts and may occur suddenly in crops or multiples. there are 4 types of syringoma: a localized form, a form associated with down syndrome, a generalized form that encompases multiple and eruptive syringomas, and a familial form. syringomas are usually asymptomatic; however, rarely, individuals can experience extreme itching (pruritus), especially while sweating. they are found more commonly in caucasians, and in females at puberty or near middle-age. syringomas may be treated surgically using different methods such as high frequency electric current (electrosurgery) or laser. last updated: 11/14/2016

MalaCards based summary: Syringoma is related to vulvar syringoma and malignant syringoma. An important gene associated with Syringoma is S100B (S100 Calcium Binding Protein B), and among its related pathways are Aurora B signaling and Cytoskeletal Signaling. Affiliated tissues include skin, eye and bone, and related mouse phenotype muscle.

Wikipedia:71 Syringomas are harmless eccrine sweat duct tumors, typically found clustered on eyelids, although they... more...

Related Diseases for Syringoma

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Diseases in the Syringoma family:

Malignant Syringoma

Diseases related to Syringoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 197)
idRelated DiseaseScoreTop Affiliating Genes
1vulvar syringoma12.0
2malignant syringoma11.9
3chondroid syringoma of the vulva11.7
4syringomas natal teeth oligodontia11.7
5malignant acrospiroma10.8
6immunodeficiency due to a classical component pathway complement deficiency10.3MUC1, VIM
7autosomal recessive stickler syndrome10.3MUC1, VIM
8cervical lymphoepithelioma-like carcinoma10.3ESR1, MUC1
9lupus - neurological sequelae10.3S100B, VIM
10avian influenza10.2MUC1, VIM
11benign schwannoma10.2S100B, VIM
12vulvar angiokeratoma10.2MUC1, VIM
13jejunal neuroendocrine tumor10.2S100B, VIM
14lymphangiosarcoma10.2MUC1, VIM
15poliomyelitis10.2ESR1, MUC1
16progeria10.2MUC1, VIM
17gestational trophoblastic neoplasm10.2MUC1, VIM
18appendix mucinous cystadenocarcinoma10.2MUC1, VIM
19lucey-driscoll syndrome10.2MUC1, S100B
20secondary pulmonary hemosiderosis10.2MUC1, S100B
21chondroblastoma10.2MUC1, VIM
22invasive mole10.2MUC1, S100B
23substance abuse10.2ESR1, MUC1
24subependymal glioma10.2MUC1, VIM
25stomach diverticulosis10.2S100B, VIM
26pemphigus vegetans10.2MUC1, S100B
27differentiating neuroblastoma10.2MUC1, VIM
28myxopapillary ependymoma10.2GFAP, VIM
29corneal intraepithelial neoplasm10.2MUC1, S100B
30central nervous system mature teratoma10.2ESR1, S100B
31nephrogenic adenoma of urinary bladder10.2GFAP, VIM
32adult brainstem gliosarcoma10.2GFAP, VIM
33endocardium cancer10.2MUC1, S100B
34precursor t-lymphoblastic lymphoma/leukemia10.2MUC1, S100B
35tumor of exocrine pancreas10.2ESR1, MUC1
36ovarian insufficiency due to fsh resistance10.2MUC1, VIM
37osteochondrodysplasia10.2ESR1, S100B
38onychocytic matricoma10.2S100B, VIM
39calcific tendinitis10.2GFAP, VIM
40anus adenocarcinoma10.2ESR1, MUC1
41bronchial mucus gland adenoma10.2GFAP, S100B
42sclerosing hemangioma10.2ESR1, MUC1
43pulmonary neuroendocrine tumor10.2MUC1, S100B
44aml with myelodysplasia-related features10.2TP63, VIM
45atypical lipomatous tumor10.2ESR1, TP63
46lung clear cell carcinoma10.2ESR1, MUC1
47adenofibroma10.2GFAP, S100B
48uterine hypoplasia10.2TP63, VIM
49uterine corpus leiomyomatosis10.2MUC1, S100B
50arthus reaction10.1ESR1, GFAP

Graphical network of the top 20 diseases related to Syringoma:



Diseases related to syringoma

Symptoms & Phenotypes for Syringoma

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MGI Mouse Phenotypes related to Syringoma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.5DES, ESR1, GFAP, TP63, VIM

Drugs & Therapeutics for Syringoma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Trial of Radiotherapy and Panitumumab in Salivary Gland MalignanciesWithdrawnNCT00984217Phase 2

Search NIH Clinical Center for Syringoma


Cochrane evidence based reviews: syringoma

Genetic Tests for Syringoma

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Anatomical Context for Syringoma

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MalaCards organs/tissues related to Syringoma:

36
Skin, Eye, Bone, Salivary gland, Breast, Lymph node, Spinal cord

Publications for Syringoma

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Articles related to Syringoma:

(show top 50)    (show all 357)
idTitleAuthorsYear
1
Dermoscopy of isolated syringoma of the vulva. (28087025)
2017
2
Coexistence of Adult Onset Eruptive Syringoma and Bilateral Renal Cell Carcinoma: A Case Report. (27922891)
2017
3
Diagnosis of a rapidly growing preauricular nodule: chondroid syringoma or pleomorphic adenoma? (27874890)
2016
4
Malignant chondroid syringoma in a West African cancer institute: A case report. (27372026)
2016
5
Chondroid Syringoma of the Hypothenar Region. (27403399)
2016
6
Emphasizing the pivotal role of fine-needle aspiration cytology in a case of recurrent malignant chondroid syringoma. (27279688)
2016
7
Syringoma: A clinicopathological study of 244 cases. (27112697)
2016
8
Chondroid syringoma invading the distal phalanx of the thumb: a case report. (27090725)
2016
9
Chondroid syringoma of the axilla: An unusual tumor diagnosed by fine needle aspiration. (26800260)
2016
10
An unusual presentation of chondroid syringoma. (27510678)
2016
11
Chondroid Syringoma: A Case Report in the Foot and Ankle. (27587378)
2016
12
Giant Chondroid Syringoma of the Lower Eyelid. (27203613)
2016
13
Local recurrence of cutaneous mixed tumor (chondroid syringoma) as malignant mixed tumor of the thumb 20 years after initial diagnosis. (28035707)
2016
14
Generalized eruptive syringoma: A clinical dilemma. (27057500)
2016
15
Axillary syringomas misdiagnosed as pseudoxanthoma elasticum for years. (26078007)
2015
16
Chondroid Syringoma: A Case Report. (26171105)
2015
17
Spinal cord compression secondary to metastasis of malignant chondroid syringoma: case report. (25555054)
2015
18
Chondroid Syringoma of the Foot: A Rare Diagnosis. (26015300)
2015
19
Chondroid syringoma of the nasal dorsum. (25565228)
2015
20
Syringoma of vulva: an unusual presentation. Clinical, morphological and immunohistochemical aspects. (25920186)
2015
21
Apocrine Chondroid Syringoma of the Eyelid. (26711479)
2015
22
Chondroid Syringoma of the Philtral Dimple. (26865793)
2015
23
Dermoscopic features of eruptive milium-like syringoma. (25961748)
2015
24
Axillary syringomas mimicking Fox-Fordyce disease. (26500884)
2015
25
Familial eruptive syringoma in a Nigerian girl. (26452448)
2015
26
Extramammary Paget's disease associated with underlying syringoma. (26055941)
2015
27
Generalized eruptive syringoma. (25814740)
2015
28
Eccrine Squamous Syringometaplasia of Underlying Syringoma Associated with Tegafur/Gimeracil/Oteracil (TS-1). (25766447)
2015
29
Chondroid syringoma: report of four cases. (26137735)
2015
30
Treatment of periorbital syringoma by the pinhole method using a carbon dioxide laser in 29 Asian patients. (25803568)
2015
31
Papular Clear Cell Hyperplasia of the Eccrine Duct: A Precursor Lesion of Clear Cell Syringoma? (26291420)
2015
32
Malignant chondroid syringoma of the pinna. (26430319)
2015
33
Eruptive Syringoma in the Elderly: A Case Report. (26724882)
2015
34
Vulvar Syringoma in a Postmenopausal Woman: A Case Report. (26592076)
2015
35
Giant Chondroid Syringoma of the Breast. (25919351)
2015
36
Chondroid syringoma of the medial canthus. (24744935)
2014
37
What is your diagnosis? eruptive syringoma. (24505588)
2014
38
Fine-needle aspiration cytology of chondroid syringoma of fore arm: Report of a rare case. (25538390)
2014
39
Giant benign Chondroid Syringoma in the elbow. (25203335)
2014
40
Erratum to: Benign chondroid syringoma (mixed tumor of skin) on the flank with satellites: case report and literature review. (25341655)
2014
41
An important mimicker: plaque-type syringoma mistakenly diagnosed as microcystic adnexal carcinoma. (25111356)
2014
42
Chondroid syringoma of the ear lobule: a unique case. (24817245)
2014
43
Chondroid syringoma of the forearm: a case report of a rare localization. (25284863)
2014
44
Chondroid syringoma with extensive bone formation: a case report and review of the literature. (25478357)
2014
45
Plaque-like syringoma with involvement of deep reticular dermis. (25437993)
2014
46
Chondroid syringoma with extensive osseous differentiation: a rare finding. (24943789)
2014
47
An unusual case of generalised eruptive syringoma in an adult male. (25382918)
2014
48
Eruptive syringoma localized in intertriginous areas. (24393317)
2014
49
Vulvar syringoma: a rare case report. (25302203)
2014
50
Benign chondroid syringoma (mixed tumor of skin) on the flank with satellites: case report and literature review. (25271109)
2014

Variations for Syringoma

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Cosmic variations for Syringoma:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1COSM476BRAFskin,abdomen,benign melanocytic nevus,eruptivec.1799T>Ap.V600E4
2COSM214343CYLDskin,face,adnexal tumour,trichoepitheliomac.1327C>Tp.Q443*4

Expression for genes affiliated with Syringoma

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Search GEO for disease gene expression data for Syringoma.

Pathways for genes affiliated with Syringoma

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GO Terms for genes affiliated with Syringoma

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Cellular components related to Syringoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament cytoskeletonGO:00451119.9DES, GFAP
2intermediate filamentGO:00058829.5DES, GFAP, VIM
3nuclear chromatinGO:00007908.8ESR1, MUC1, TP63
4cytoplasmGO:00057377.0DES, ESR1, GFAP, MUC1, S100B, SERPINB5

Biological processes related to Syringoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:00451099.9DES, VIM
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.8MUC1, TP63
3epithelial cell developmentGO:00020649.6ESR1, TP63
4muscle filament slidingGO:00300499.5DES, VIM

Molecular functions related to Syringoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052008.9DES, GFAP, VIM
2identical protein bindingGO:00428027.7DES, ESR1, GFAP, S100B, TP63, VIM

Sources for Syringoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet