MCID: SYR003
MIFTS: 41

Syringoma

Categories: Rare diseases, Skin diseases, Cancer diseases

Aliases & Classifications for Syringoma

MalaCards integrated aliases for Syringoma:

Name: Syringoma 12 49 51 41 14 69
Syringomas 72

Classifications:



External Ids:

Disease Ontology 12 DOID:2065
MeSH 41 D018252
NCIt 46 C3761
UMLS 69 C0206673

Summaries for Syringoma

NIH Rare Diseases : 49 Syringomas are firm yellowish, translucent, or skin colored papules that are often found on the face, particularly around the eyes, but may also appear elsewhere on the face, in the armpits, umbilicus, upper chest, and genitalia. They arise from the sweat ducts and may occur suddenly in crops or multiples. There are 4 types of syringoma: a localized form, a form associated with Down syndrome, a generalized form that encompases multiple and eruptive syringomas, and a familial form. Syringomas are usually asymptomatic; However, rarely, individuals can experience extreme itching (pruritus), especially while sweating. They are found more commonly in Caucasians, and in females at puberty or near middle-age. Syringomas may be treated surgically using different methods such as high frequency electric current (electrosurgery) or laser. Last updated: 11/14/2016

MalaCards based summary : Syringoma, also known as syringomas, is related to hidradenoma and nodular hidradenoma. An important gene associated with Syringoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are Cytoskeletal Signaling and MicroRNAs in cancer. Affiliated tissues include skin, eye and salivary gland, and related phenotypes are behavior/neurological and muscle

Wikipedia : 72 Syringomas are harmless eccrine sweat duct tumors, typically found clustered on eyelids, although they... more...

Related Diseases for Syringoma

Diseases in the Syringoma family:

Syringomas, Multiple Malignant Syringoma

Diseases related to Syringoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 206)
# Related Disease Score Top Affiliating Genes
1 hidradenoma 30.4 MUC1 VIM
2 nodular hidradenoma 30.2 MUC1 VIM
3 spiradenoma 30.0 MUC1 S100B VIM
4 osteochondroma 30.0 S100B VIM
5 syringocystadenoma papilliferum 29.0 DES GFAP MUC1 S100B VIM
6 pleomorphic adenoma 28.3 GFAP MUC1 S100B SERPINB5 TP63 VIM
7 vulvar syringoma 12.1
8 malignant syringoma 12.0
9 syringomas, multiple 11.8
10 chondroid syringoma of the vulva 11.8
11 syringomas natal teeth oligodontia 11.8
12 malignant acrospiroma 10.9
13 malignant peritoneal mesothelioma 10.4 MUC1 VIM
14 papillary tumor of the pineal region 10.4 MUC1 VIM
15 malignant mixed mullerian tumor 10.4 MUC1 VIM
16 hydromyelia 10.4 S100B VIM
17 adenofibroma 10.4 MUC1 VIM
18 bednar tumor 10.4 S100B VIM
19 sarcomatoid mesothelioma 10.4 MUC1 VIM
20 primary hepatic neuroendocrine carcinoma 10.4 S100B VIM
21 localized hypertrophic neuropathy 10.4 MUC1 S100B
22 sclerosing perineurioma 10.4 MUC1 S100B
23 reticular perineurioma 10.4 MUC1 S100B
24 sertoli cell tumor 10.4 MUC1 VIM
25 mucinous cystadenocarcinoma 10.4 MUC1 VIM
26 chondroid chordoma 10.4 MUC1 VIM
27 non-functioning pituitary adenoma 10.4 MUC1 S100B
28 epithelioid malignant peripheral nerve sheath tumor 10.4 MUC1 S100B
29 aggressive digital papillary adenocarcinoma 10.4 MUC1 S100B
30 odontogenic myxoma 10.3 S100B VIM
31 skin glomus tumor 10.3 DES VIM
32 infantile digital fibromatosis 10.3 DES VIM
33 lymphangiomatosis 10.3 DES VIM
34 pericardial mesothelioma 10.3 MUC1 VIM
35 angiolipoma 10.3 DES VIM
36 functioning pituitary adenoma 10.3 MUC1 S100B
37 osteofibrous dysplasia 10.3 MUC1 VIM
38 meningeal melanocytoma 10.3 MUC1 S100B
39 secretory meningioma 10.3 MUC1 VIM
40 spindle cell lipoma 10.3 DES VIM
41 epulis 10.3 DES VIM
42 rhabdoid meningioma 10.3 GFAP VIM
43 epithelioid leiomyosarcoma 10.3 DES VIM
44 benign metastasizing leiomyoma 10.3 DES VIM
45 spindle cell thymoma 10.3 DES MUC1
46 ependymoblastoma 10.3 GFAP VIM
47 astroblastoma 10.3 GFAP VIM
48 congenital fibrosarcoma 10.3 DES VIM
49 melanotic neuroectodermal tumor 10.3 GFAP VIM
50 intraneural perineurioma 10.3 MUC1 S100B

Graphical network of the top 20 diseases related to Syringoma:



Diseases related to Syringoma

Symptoms & Phenotypes for Syringoma

MGI Mouse Phenotypes related to Syringoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.5 DES ESR1 GFAP S100B SERPINB5 TP63
2 muscle MP:0005369 9.02 DES ESR1 GFAP TP63 VIM

Drugs & Therapeutics for Syringoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trial of Radiotherapy and Panitumumab in Salivary Gland Malignancies Withdrawn NCT00984217 Phase 2 Panitumumab

Search NIH Clinical Center for Syringoma

Cochrane evidence based reviews: syringoma

Genetic Tests for Syringoma

Anatomical Context for Syringoma

MalaCards organs/tissues related to Syringoma:

38
Skin, Eye, Salivary Gland, Bone, Lymph Node, Spinal Cord, Liver

Publications for Syringoma

Articles related to Syringoma:

(show top 50) (show all 370)
# Title Authors Year
1
A rare large cutaneous chondroid syringoma involving a toe: A case report. ( 29384887 )
2018
2
Plaque-Type Syringoma Coexisting With Basal Cell Carcinoma. ( 29419541 )
2018
3
Extensive Eruptive Syringoma After Liver Transplantation. ( 28971206 )
2018
4
A case of milium-like syringoma limited to the neck. ( 28449287 )
2017
5
A Case of Eruptive Syringoma Mimicking Plane Warts. ( 28761852 )
2017
6
Malignant chondroid syringoma of thigh with late metastasis to lung: A very rare case report. ( 28937387 )
2017
7
Generalized eruptive syringoma with poor clinical response to systemic treatment with acitretin. ( 28177590 )
2017
8
Coexistence of Adult Onset Eruptive Syringoma and Bilateral Renal Cell Carcinoma: A Case Report. ( 27922891 )
2017
9
Dermoscopy of isolated syringoma of the vulva. ( 28087025 )
2017
10
Plaque-Type Syringoma: A Case Report. ( 29118702 )
2017
11
Chondroid Syringoma of a Cheek. ( 28582289 )
2017
12
Melanoma in situ and syringoma: a rare collision tumor. Clinical-pathological report of a case. ( 29267461 )
2017
13
Chondroid Syringoma: Fine-needle Aspiration Cytology of a Rare Entity at an Unusual Site. ( 28892909 )
2017
14
Case of chondroid syringoma mimicking as nodular hidradenoma: A diagnostic pitfall on cytopathology. ( 28772003 )
2017
15
Coexistence of eruptive syringoma and bilateral nipple vitiligo: Could there be a common immunopathogenesis? ( 28971181 )
2017
16
An unusual presentation of chondroid syringoma. ( 27510678 )
2016
17
Chondroid Syringoma of the Hypothenar Region. ( 27403399 )
2016
18
Emphasizing the pivotal role of fine-needle aspiration cytology in a case of recurrent malignant chondroid syringoma. ( 27279688 )
2016
19
A rare association in Down syndrome: milialike idiopathic calcinosis cutis and palpebral syringoma. ( 28099543 )
2016
20
Chondroid Syringoma on Face. ( 28913278 )
2016
21
Chondroid syringoma invading the distal phalanx of the thumb: a case report. ( 27090725 )
2016
22
Giant Chondroid Syringoma of the Lower Eyelid. ( 27203613 )
2016
23
Chondroid syringoma of the axilla: An unusual tumor diagnosed by fine needle aspiration. ( 26800260 )
2016
24
Generalized eruptive syringoma: A clinical dilemma. ( 27057500 )
2016
25
Syringoma: A clinicopathological study of 244 cases. ( 27112697 )
2016
26
Malignant chondroid syringoma in a West African cancer institute: A case report. ( 27372026 )
2016
27
Diagnosis of a rapidly growing preauricular nodule: chondroid syringoma or pleomorphic adenoma? ( 27874890 )
2016
28
Chondroid Syringoma: A Case Report in the Foot and Ankle. ( 27587378 )
2016
29
Local recurrence of cutaneous mixed tumor (chondroid syringoma) as malignant mixed tumor of the thumb 20 years after initial diagnosis. ( 28035707 )
2016
30
Chondroid syringoma: report of four cases. ( 26137735 )
2015
31
Familial eruptive syringoma in a Nigerian girl. ( 26452448 )
2015
32
Vulvar Syringoma in a Postmenopausal Woman: A Case Report. ( 26592076 )
2015
33
Chondroid Syringoma: A Case Report. ( 26171105 )
2015
34
Spinal cord compression secondary to metastasis of malignant chondroid syringoma: case report. ( 25555054 )
2015
35
Papular Clear Cell Hyperplasia of the Eccrine Duct: A Precursor Lesion of Clear Cell Syringoma? ( 26291420 )
2015
36
Treatment of periorbital syringoma by the pinhole method using a carbon dioxide laser in 29 Asian patients. ( 25803568 )
2015
37
Eccrine Squamous Syringometaplasia of Underlying Syringoma Associated with Tegafur/Gimeracil/Oteracil (TS-1). ( 25766447 )
2015
38
Chondroid Syringoma of the Philtral Dimple. ( 26865793 )
2015
39
Syringoma of vulva: an unusual presentation. Clinical, morphological and immunohistochemical aspects. ( 25920186 )
2015
40
Giant Chondroid Syringoma of the Breast. ( 25919351 )
2015
41
Dermoscopic features of eruptive milium-like syringoma. ( 25961748 )
2015
42
Axillary syringomas mimicking Fox-Fordyce disease. ( 26500884 )
2015
43
Generalized eruptive syringoma. ( 25814740 )
2015
44
Apocrine Chondroid Syringoma of the Eyelid. ( 26711479 )
2015
45
Axillary syringomas misdiagnosed as pseudoxanthoma elasticum for years. ( 26078007 )
2015
46
Extramammary Paget's disease associated with underlying syringoma. ( 26055941 )
2015
47
Chondroid Syringoma of the Foot: A Rare Diagnosis. ( 26015300 )
2015
48
Malignant chondroid syringoma of the pinna. ( 26430319 )
2015
49
Chondroid syringoma of the nasal dorsum. ( 25565228 )
2015
50
Eruptive Syringoma in the Elderly: A Case Report. ( 26724882 )
2015

Variations for Syringoma

Cosmic variations for Syringoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM476 BRAF skin,abdomen,benign melanocytic nevus,eruptive c.1799T>A p.V600E 4

Expression for Syringoma

Search GEO for disease gene expression data for Syringoma.

Pathways for Syringoma

GO Terms for Syringoma

Cellular components related to Syringoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.33 ESR1 MUC1 TP63
2 intermediate filament cytoskeleton GO:0045111 9.26 DES GFAP
3 cytoplasm GO:0005737 9.23 DES ESR1 GFAP MUC1 S100B SERPINB5
4 intermediate filament GO:0005882 9.13 DES GFAP VIM

Biological processes related to Syringoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 long-term synaptic potentiation GO:0060291 9.43 GFAP S100B
2 muscle filament sliding GO:0030049 9.4 DES VIM
3 astrocyte development GO:0014002 9.37 GFAP VIM
4 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.32 MUC1 TP63
5 epithelial cell development GO:0002064 9.26 ESR1 TP63
6 Bergmann glial cell differentiation GO:0060020 9.16 GFAP VIM
7 intermediate filament-based process GO:0045103 8.96 GFAP VIM
8 intermediate filament organization GO:0045109 8.8 DES GFAP VIM

Molecular functions related to Syringoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.13 DES GFAP VIM
2 identical protein binding GO:0042802 9.1 DES ESR1 GFAP S100B TP63 VIM

Sources for Syringoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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