Syringoma malady

Wikipedia: Syringomas are harmless sweat duct tumors, typically found clustered on eyelids, although they may also...⁴⁴ more...

MalaCards: Syringoma, also known as syringoma nos (morphologic abnormality), is related to vulvar syringoma and malignant syringoma. An important gene associated with Syringoma is DAND5 (DAN domain family, member 5), and among its related pathways are Nuclear signaling by ERBB4 and Cytoskeleton remodeling Neurofilaments. The compounds 4-hydroxytamoxifen and 12-o-tetradecanoylphorbol 13-acetate have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are integument and behavior/neurological.

Aliases & Descriptions:

syringoma 6 8 32 43 syringoma nos (morphologic abnormality) 6

syringoma (morphologic abnormality) 6 syringoma (disorder) 6

Diseases related to syringoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 369)

id	Related Disease	Score	Top Affiliating Genes
1	vulvar syringoma	31.5	ESR1, PGR
2	malignant syringoma	30.6	CLEC2A, MARCKS, DAND5, KRT20
3	cholangiolocellular carcinoma	13.5	KRT20, KRT19
4	psammomatous meningioma	13.5	MUC1, GFAP
5	myxopapillary ependymoma	13.5	S100B, GFAP
6	gliofibroma	13.5	S100B, GFAP
7	supernumerary nipples	13.5	PIP, KRT20
8	langerhans-cell histiocytosis	13.5	S100A1, S100B
9	papillary ependymoma	13.5	S100B, GFAP
10	myoepithelial carcinoma	13.5	S100A1, GFAP
11	intraneural perineurioma	13.5	MUC1, S100B
12	eccrine porocarcinoma	13.5	MUC1, KRT1
13	choroid plexus carcinoma	13.4	S100B, GFAP
14	anaplastic ganglioglioma	13.4	S100B, GFAP
15	vulva cancer	13.4	PIP, KRT20
16	ampulla of vater adenocarcinoma	13.4	MUC1, KRT20
17	signet ring basal cell carcinoma	13.4	PIP, KRT20
18	acanthoma	13.3	CLEC2A, KRT1
19	epidermolytic palmoplantar keratoderma	13.3	KRT1, KRT14
20	ichthyosis hystrix, curth macklin type	13.3	KRT5, KRT1
21	pulmonary alveolar proteinosis	13.3	MUC1, CEACAM3, KRT19
22	gemistocytic astrocytoma	13.3	S100B, GFAP
23	epidermolytic hyperkeratosis	13.3	KRT5, KRT1
24	anaplastic ependymoma	13.3	MUC1, S100B, GFAP
25	choroid plexus papilloma	13.3	MUC1, S100B, GFAP
26	pancreatic mucinous cystadenoma	13.2	KRT20, PGR
27	papillary serous adenocarcinoma	13.2	KRT20, PGR
28	neuroendocrine tumor	13.2	CEACAM3, KRT20, KRT19
29	glassy cell carcinoma of the cervix	13.2	ESR1, PGR
30	cribriform carcinoma	13.2	ESR1, PGR
31	catamenial pneumothorax	13.2	ESR1, PGR
32	progesterone resistance	13.2	ESR1, PGR
33	spindle cell thymoma	13.2	MUC1, DES
34	hidrocystoma	13.2	PIP, SGTA, KRT19
35	gender identity disorder	13.1	ESR1, PGR
36	apocrine adenocarcinoma	13.1	PIP, PGR
37	progesterone-receptor positive breast cancer	13.1	ESR1, PGR
38	adenoameloblastoma	13.1	KRT1, KRT19, KRT14
39	retroperitoneal leiomyosarcoma	13.1	S100A1, DES
40	desmoplastic small round cell tumor	13.1	MUC1, DES
41	ovarian mucinous neoplasm	13.1	MUC1, CEACAM3, KRT20
42	malignant giant cell tumor of soft parts	13.1	S100B, DES
43	meningioma	13.1	ESR1, PGR
44	glomangioma	13.1	S100A1, DES
45	cutaneous paget's disease	13.1	PIP, MUC1, CEACAM3, KRT20
46	mucoepidermoid carcinoma	13.1	MUC1, S100A1, KRT14
47	cervical endometrioid adenocarcinoma	13.1	ESR1, PGR
48	large cell carcinoma	13.1	CEACAM3, KRT5, KRT20
49	hidradenitis suppurativa	13.1	PIP, KRT1, KRT14
50	progesterone-receptor negative breast cancer	13.1	ESR1, PGR

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to syringoma:

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MGI Mouse Phenotypes related to syringoma:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument phenotype	MP:0010771	7.4	MUC1, PGR, KRT14, KRT19, KRT1, KRT5
2	behavior/neurological phenotype	MP:0005386	7.1	DES, GFAP, KRT5, MARCKS, S100B, S100A1

Articles related to syringoma:

id	Title	Authors	Year	Affiliating Genes
1	Malignant chondroid syringoma with bone invasion: a case report and review of the literature. (15365374)	Takahashi H.... Md M.T.	2004	GFAP
2	Milium-like syringoma: a case study on histogenesis. (15005692)	Wang K.H.... Lee W.R.	2004	CEACAM3
3	Vulvar syringoma: a clinicopathologic and immunohistologic study of 18 patients and results of treatment. (12734503)	Huang Y.H.... Hong H.S.	2003	ESR1
4	Immunohistochemical analysis of keratin expression in clear cell syringoma. A comparative study with conventional syringoma. (9243365)	Ohnishi T.... Watanabe S.	1997	MUC1, KRT1
5	Chondroid syringoma. Immunohistologic indications of myoepithelial differentiation (8050903)	Wilk M.... Wimheuer R.	1994	S100B, VIM, DES
6	Disseminated syringomas of the upper extremities. Case history and immunohistochemical and ultrastructural study. (1694147)	Metze D.... Gebhart W.	1990	MUC1

Genes related to syringoma according to GeneCards:

(show all 21)

id	Symbol	Description	Score	GeneCards Section Context
1	DAND5	DAN domain family, member 5	11.0	Disorders
2	CLEC2A	C-type lectin domain family 2, member A	11.0
3	MARCKS	myristoylated alanine-rich protein kinase C substrate	11.0
4	KRT1	keratin 1	11.0	Publications
5	KRT20	keratin 20	11.0
6	S100A1	S100 calcium binding protein A1	11.0
7	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	11.0	Publications
8	MUC1	mucin 1, cell surface associated	11.0	Publications
9	KRT19	keratin 19	11.0
10	S100B	S100 calcium binding protein B	11.0	Publications
11	GFAP	glial fibrillary acidic protein	11.0	Publications
12	ESR1	estrogen receptor 1	11.0	Publications
13	PIP	prolactin-induced protein	11.0
14	SGTA	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	11.0
15	CSNK1A1	casein kinase 1, alpha 1	11.0
16	ANXA11	annexin A11	11.0
17	KRT5	keratin 5	11.0
18	KRT14	keratin 14	11.0
19	DES	desmin	11.0	Publications
20	VIM	vimentin	11.0	Publications
21	PGR	progesterone receptor	11.0

Pathways related to syringoma according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Nuclear signaling by ERBB438	9.4	PGR, GFAP, ESR1
2	Cytoskeleton remodeling Neurofilaments10	8.6	VIM, GFAP, DES
3	Cytoskeleton remodeling_Neurofilaments41	8.4	DES, GFAP, VIM
4	Cytoskeleton remodeling Keratin filaments10	8.3	VIM, KRT5, KRT1, KRT19, KRT14
5	Cytoskeletal Signaling3	8.3	VIM, KRT5, KRT19, DES
6	Cytoskeleton remodeling_Keratin filaments41	8.3	KRT14, KRT19, KRT1, KRT5, VIM

Compounds related to syringoma according to GeneDecks:

(show top 50)    (show all 86)

id	Compound	Score	Top Affiliating Genes
1	4-hydroxytamoxifen32	10.4	S100B
2	12-o-tetradecanoylphorbol 13-acetate32	10.4	MARCKS, KRT1
3	threonine32	9.7	KRT5, KRT1, KRT14
4	Ethynodiol Diacetate9 9	10.7	PGR, ESR1
5	ici 16438432	9.6	PGR, ESR1
6	progestin32	9.4	DES, VIM
7	glucose32	9.3	DES, KRT19, MARCKS, S100B
8	eosin32	9.3	GFAP, S100B, MUC1, VIM
9	2-methoxyethanol32	9.2	KRT14, S100A1, VIM
10	orcein32	9.1	DES, S100B, VIM
11	retinoic acid32 42 18	11.1	PGR, GFAP, KRT19, KRT1, ESR1, S100B
12	toluidine32	9.1	VIM, S100A1, DES
13	cysteine32	8.8	GFAP, KRT14, DAND5, S100B, S100A1, MUC1
14	calcipotriol32 42 9 9	11.8	VIM, KRT5, KRT14
15	biotin32 9 18 9	11.7	DES, KRT1, S100A1, MUC1, VIM
16	s 10032	8.7	DES, GFAP, S100B, MUC1, VIM
17	reticulin32	8.7	DES, GFAP, S100B, MUC1, VIM
18	hyaluronic acid32 18	9.6	DES, KRT19, KRT20, MUC1, VIM
19	methotrexate32 34 42 9 9	12.6	PGR, ESR1, CEACAM3, MUC1, VIM
20	chloramphenicol32 9 9	10.5	KRT14, ESR1, S100B, MUC1, VIM
21	paclitaxel32 34 9 9	11.3	PGR, GFAP, KRT19, ESR1, S100B, VIM
22	thymidine32 18	9.3	DES, GFAP, KRT19, CEACAM3, S100B, MUC1
23	formaldehyde32 18	9.2	DES, GFAP, KRT19, KRT20, S100B, MUC1
24	adriamycin32	8.2	PGR, DES, KRT19, CEACAM3, MUC1, VIM
25	steroid32	8.1	PGR, DES, KRT19, KRT1, ESR1, CEACAM3
26	creatinine32	8.1	DES, GFAP, KRT19, CEACAM3, S100B, MUC1
27	lactate32	8.1	DES, GFAP, KRT19, CEACAM3, S100B, VIM
28	doxorubicin32 34 9 9	11.0	PGR, DES, KRT20, ESR1, CEACAM3, VIM
29	dihydrotestosterone32 9 18 9	11.0	PGR, DES, ESR1, MUC1, VIM, PIP
30	bromodeoxyuridine32	7.9	DES, GFAP, KRT14, KRT19, KRT1, S100B
31	tamoxifen32 34 9 9	10.9	PGR, KRT14, ESR1, CEACAM3, MUC1, VIM
32	aspartate32	7.8	PGR, GFAP, KRT19, KRT1, KRT5, CEACAM3
33	retinoid32	7.8	PGR, KRT14, KRT19, KRT1, KRT5, ESR1
34	proline32	7.8	DES, KRT14, KRT1, KRT5, S100B, VIM
35	b 72332	7.7	PIP, DES, KRT19, KRT20, CEACAM3, S100B
36	iron32 18	8.7	DES, GFAP, KRT14, KRT19, KRT20, S100B
37	glycogen32 18	8.6	CSNK1A1, DES, GFAP, KRT19, MARCKS, S100B
38	estradiol32 9 18 9	10.5	PGR, DES, GFAP, KRT19, ESR1, MUC1
39	alanine32	7.5	PGR, GFAP, KRT14, KRT5, MARCKS, CEACAM3
40	mucicarmine32	7.5	DES, KRT14, KRT20, CEACAM3, S100B, S100A1
41	arginine32	7.3	GFAP, KRT14, KRT1, KRT5, S100B, VIM
42	vegf32	7.1	PGR, DES, GFAP, KRT19, KRT20, ESR1
43	hematoxylin32	7.0	KRT14, KRT19, KRT20, KRT1, CEACAM3, S100B
44	calcium32 9 18 9	9.9	KRT1, KRT19, KRT14, GFAP, DES, KRT5
45	tyrosine32	6.8	CSNK1A1, DES, GFAP, KRT14, KRT19, KRT20
46	serine32	6.6	CSNK1A1, DES, GFAP, KRT14, KRT19, KRT1
47	testosterone32 9 18 9	9.4	PGR, DES, GFAP, KRT19, KRT20, KRT1
48	paraffin32	5.4	PGR, DES, GFAP, KRT14, KRT19, KRT20
49	estrogen32	5.4	PIP, PGR, DES, GFAP, KRT14, KRT19
50	progesterone32 42 9 18 9	9.4	VIM, PIP, MUC1, S100A1, S100B, PGR

Cellular components related to syringoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:005882	7.1	VIM, KRT5, KRT1, KRT20, KRT19, KRT14

Biological processes related to syringoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	epidermis development	GO:008544	9.3	KRT5, KRT1, KRT14
2	Bergmann glial cell differentiation	GO:060020	9.3	VIM, GFAP
3	intermediate filament organization	GO:045109	9.2	VIM, KRT20, GFAP
4	astrocyte development	GO:014002	9.1	GFAP, VIM

Molecular functions related to syringoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	S100 protein binding	GO:044548	9.6	S100A1, S100B, ANXA11
2	structural constituent of cytoskeleton	GO:005200	7.0	VIM, DES, GFAP, KRT14, KRT19, KRT20
3	protein binding	GO:005515	4.2	KRT1, KRT20, KRT19, KRT14, DES, CSNK1A1