MCID: SYR003
MIFTS: 48

Syringoma malady

Rare diseases, Skin diseases, Immune diseases, Muscle diseases, Cancer diseases categories

Aliases & Classifications for Syringoma

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Syringoma, Aliases & Descriptions:

Name: Syringoma 9 41 11 43 60
 
Syringoma Nos 9


Classifications:



External Ids:

Disease Ontology9 DOID:2065
MeSH33 D018252
NCIt38 C3761

Summaries for Syringoma

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NIH Rare Diseases:41 Syringomas are firm yellowish, translucent, or skin colored papules that are often found on the face, particularly around the eyes. they may occur suddenly in crops or multiples. they arise from the sweat ducts. they usually cause no symptoms. they are not associated with underlying abnormality. they are found more commonly in caucasians, and in females at puberty or near middle-age. last updated: 8/6/2009

MalaCards based summary: Syringoma, also known as syringoma nos, is related to hidradenoma and adenoma. An important gene associated with Syringoma is KRT1 (keratin 1), and among its related pathways are Aurora B signaling and Signaling mediated by p38-alpha and p38-beta. The compounds orcein and eosin have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and bone, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Wikipedia:63 Syringomas are harmless sweat duct tumors, typically found clustered on eyelids, although they may also... more...

Related Diseases for Syringoma

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Diseases in the Syringoma family:

Malignant Syringoma

Diseases related to Syringoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1hidradenoma30.7MUC1
2adenoma30.0S100A1, KRT14, MUC1, KRT19, CEACAM3
3pleomorphic adenoma29.3KRT14, DES, GFAP, S100B, VIM, MUC1
4adenocarcinoma28.8KRT19, VIM, KRT14, KRT1, CEACAM3, MUC1
5vulvar syringoma10.5
6eccrine porocarcinoma10.5MUC1
7nephrogenic adenoma10.5S100A1
8subependymal giant cell astrocytoma10.5GFAP
9giant cell glioblastoma10.5GFAP
10mixed glioma10.5GFAP
11rosai-dorfman disease10.5S100B
12neurilemmoma10.5GFAP
13adenomatoid tumor10.5VIM
14fibrous meningioma10.4MUC1, S100B
15infantile myofibromatosis10.4DES
16langerhans-cell histiocytosis10.4S100A1, S100B
17cystadenocarcinoma10.4CEACAM3, MUC1
18malignant syringoma10.4
19mucinous cystadenocarcinoma10.3MUC1, CEACAM3
20myxopapillary ependymoma10.3GFAP, S100B
21paget disease, extramammary10.3MUC1, CEACAM3
22papillary ependymoma10.3S100B, GFAP
23choroid plexus carcinoma10.3GFAP, S100B
24thymic carcinoma10.3CEACAM3, MUC1
25gemistocytic astrocytoma10.3S100B, GFAP
26pineocytoma10.3S100B, GFAP
27clear cell ependymoma10.3VIM, MUC1
28epithelial-myoepithelial carcinoma10.3KRT14
29mammary paget's disease10.3ESR1, MUC1
30ganglioglioma10.3S100B, GFAP
31rhabdoid meningioma10.3VIM, GFAP
32secretory meningioma10.3VIM, MUC1
33malignant pleural mesothelioma10.3CEACAM3, MUC1
34astroblastoma10.3VIM, GFAP
35gastrointestinal carcinoma10.3KRT19, CEACAM3
36desmoplastic small round cell tumor10.2MUC1, DES
37ganglioneuroma10.2S100B, GFAP
38adenosquamous carcinoma10.2MUC1, KRT19
39tubular adenocarcinoma10.2MUC1, ESR1
40choroid plexus papilloma10.2S100B, GFAP, MUC1
41anaplastic ependymoma10.2GFAP, MUC1, S100B
42hemangioblastoma10.2S100B, MUC1, GFAP
43paraganglioma10.2GFAP, S100A1, S100B
44pilocytic astrocytoma10.2S100B, GFAP
45syringocystadenoma papilliferum10.2
46chondroid syringoma of the vulva10.2
47syringomas natal teeth oligodontia10.2
48thyroid carcinoma, papillary10.2S100A1, KRT19, KRT1
49lipoma10.2S100A1, DES
50malignant mixed mullerian tumor10.2ESR1, VIM

Graphical network of the top 20 diseases related to Syringoma:



Diseases related to syringoma

Symptoms for Syringoma

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Drugs & Therapeutics for Syringoma

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Drug clinical trials:

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Genetic Tests for Syringoma

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Anatomical Context for Syringoma

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MalaCards organs/tissues related to Syringoma:

31
Skin, Eye, Bone, Salivary gland, Lymph node, Spinal cord, Breast

Animal Models for Syringoma or affiliated genes

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MGI Mouse Phenotypes related to Syringoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9KRT19, KRT14, MUC1, ESR1
2MP:00053818.7GFAP, ESR1, MUC1, KRT14, KRT19
3MP:00107718.5ESR1, MUC1, S100B, KRT14, KRT1, KRT19
4MP:00053698.4DES, GFAP, ESR1, VIM, S100A1
5MP:00028738.1GFAP, MUC1, S100A1, S100B, KRT19
6MP:00053768.1DES, GFAP, ESR1, VIM, MUC1, KRT14
7MP:00053868.0DES, GFAP, ESR1, VIM, S100A1, S100B
8MP:00053787.8DAND5, GFAP, ESR1, VIM, KRT14, KRT1
9MP:00107687.4DAND5, DES, GFAP, ESR1, VIM, KRT14
10MP:00053857.3KRT19, DAND5, DES, GFAP, ESR1, VIM

Publications for Syringoma

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Articles related to Syringoma:

(show top 50)    (show all 325)
idTitleAuthorsYear
1
Chondroid syringoma with extensive bone formation: a case report and review of the literature. (25478357)
2014
2
Chondroid syringoma with extensive osseous differentiation: a rare finding. (24943789)
2014
3
Chondroid syringoma of the medial canthus. (24744935)
2014
4
A curious serendipitous finding: Spitz naevus combined with a syringoma. (22671019)
2013
5
Penile syringoma: reports and review of patients with syringoma located on the penis. (23882308)
2013
6
Giant chondroid syringoma of the eyelid. (23931483)
2013
7
Facial localization of malignant chondroid syringoma: a rare case report. (23476847)
2013
8
Eruptive milium-like syringoma showing eccrine duct origin of milia. (22150478)
2012
9
Mohs micrographic surgery for recurrent chondroid syringoma of the eyebrow. (22309155)
2012
10
Commentary: treatment of syringoma using an ablative 10,600-nm carbon dioxide fractional laser. (21481062)
2011
11
Chondroid syringoma of the scalp: case report and discussion of clinical features, histopathology, and treatment. (21500172)
2011
12
Malignant chondroid syringoma: report of a case with lymph node metastasis 12 years after local excision. (21971270)
2011
13
Eruptive widespread papular eruption on the abdomen: a quiz. Clear cell syringoma, eruptive variant. (21264456)
2011
14
Autosomal dominant multiple syringomas linked to chromosome 16q22. (20132207)
2010
15
Eruptive syringoma associated with hyperthyroidism. (20527152)
2010
16
Milia with calcium deposits on the palms and soles in a patient with multiple syringoma. (20653855)
2010
17
Autoimmune acrosyringitis with ductal cysts: reclassification of case of eruptive syringoma. (19522848)
2009
18
Chondroid syringoma: a rare tumor of orofacial region. (19633639)
2009
19
Eruptive syringoma developed over a waxing skin area. (18645310)
2008
20
Syringoma-like eccrine sweat duct proliferation induced by radiation. (16469082)
2006
21
Periorbital syringoma: a pilot study of the efficacy of low-voltage electrocoagulation. (17034373)
2006
22
A rare case of chondroid syringoma arising from the lower eyelid with ectropion. (17051093)
2006
23
Elevated levels of serum carcinoembryonic antigen in a patient with eruptive syringoma. (16112373)
2005
24
Eruptive syringoma in four Black South African children. (15550160)
2004
25
Chondroid syringoma. Cytokeratin 20 immunolocalization of Merkel cells and reappraisal of apocrine folliculo-sebaceous differentiation. (15335266)
2004
26
Chondroid syringoma of the upper lip: a case report. (16027488)
2004
27
Cutaneous benign mixed tumor (chondroid syringoma) of the eyelid: clinical presentation and management. (15083078)
2004
28
Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma, spiradenoma, and syringoma. (14739501)
2004
29
Multiple syringomas in an unusual distribution. (14673269)
2003
30
Chondroid syringoma. A case report. (12038117)
2002
31
High-dose-rate endobronchial brachytherapy in endobronchial metastatic malignant chondroid syringoma. (11464090)
2001
32
Vulvar syringoma causing pruritus and carcinophobia: treatment by argon laser. (11360416)
1999
33
Eruptive syringoma. (20921761)
1998
34
Chondroid syringoma: an immunohistochemical study using antibodies to Ca 15-3, KA-93, Ca 19-9, CD44 and BM-1. (9001983)
1996
35
Hyaline cell-rich chondroid syringoma: epithelial nature of the hyaline cells. (8765182)
1996
36
Milium-like syringoma in the perianal region. (8534946)
1995
37
Chondroid syringoma. A rare occurrence in the hallux. (8394420)
1993
38
Fine needle aspiration cytology of chondroid syringoma and syringocystadenoma papilliferum. A report of two cases. (8392255)
1993
39
Eruptive syringoma. (8388104)
1993
40
Subclinical syringoma coexisting with nevocellular nevus on the vulva. (8478501)
1993
41
Generalised eruptive syringoma--a papular dermatosis. (1965678)
1990
42
Syringoma presenting as milia. (3819065)
1987
43
Multiple penile papules. Syringoma. (3662576)
1987
44
Syringoma of the ankle. (6715599)
1984
45
Chondroid syringoma. (6100183)
1984
46
Syringoma of the forehead. (6840942)
1983
47
Acral syringoma: electron microscopic studies on its origin. (6175141)
1982
48
Chondroid syringoma (mixed tumour) of radius. (6266947)
1981
49
Ultrastructure of chondroid syringoma: role of the myoepithelial cell in the development of the mixed tumor of the skin and soft tissues. (222430)
1979
50
Metastasising chondroid syringoma. (4352760)
1973

Variations for Syringoma

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Expression for genes affiliated with Syringoma

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Search GEO for disease gene expression data for Syringoma.

Pathways for genes affiliated with Syringoma

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Compounds for genes affiliated with Syringoma

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Compounds related to Syringoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1orcein439.7VIM, S100B, DES
2eosin439.5MUC1, VIM, GFAP, S100B
3progestin439.3MUC1, VIM, ESR1, DES
42-methoxyethanol439.3VIM, S100A1, KRT14
5toluidine439.3S100A1, DES, VIM
6s 100439.2GFAP, DES, VIM, MUC1, S100B
7reticulin439.2MUC1, S100B, DES, VIM, GFAP
8dihydrotestosterone43 28 24 1212.2DES, MUC1, VIM, ESR1
9chloramphenicol43 2 49 1212.0MUC1, ESR1, VIM, S100B, KRT14
10hyaluronic acid43 2410.0VIM, MUC1, DES, KRT19
11methionine438.9KRT14, S100B, VIM, GFAP, DES
12biotin43 24 1210.9KRT1, S100A1, MUC1, VIM, DES
13proline438.8DES, VIM, S100B, KRT14, KRT1
14butyrate438.8KRT19, KRT14, MUC1, VIM, GFAP
15retinoid438.8KRT19, ESR1, KRT1, KRT14, VIM
16paclitaxel43 49 1210.8S100B, VIM, KRT19, ESR1, GFAP
17threonine438.7GFAP, DES, MUC1, KRT14, S100B, KRT1
18acth438.6S100B, CEACAM3, GFAP, MUC1
19acetylcholine43 49 28 24 1212.6S100B, S100A1, VIM, GFAP, DES
20formaldehyde43 249.6S100B, MUC1, VIM, GFAP, KRT19, DES
21cisplatin43 49 59 1211.6GFAP, MUC1, ESR1, KRT19, KRT14
22methotrexate49 43 1210.6MUC1, CEACAM3, VIM, ESR1
23arginine438.6KRT14, DES, GFAP, VIM, S100B, KRT1
24estradiol43 24 1210.6MUC1, KRT19, ESR1, VIM, GFAP, DES
25tamoxifen43 49 28 1211.5KRT14, ESR1, VIM, MUC1, CEACAM3
26cyclic amp43 249.4VIM, MUC1, GFAP, DES, S100B
27adriamycin438.4CEACAM3, KRT19, MUC1, VIM, DES
28bromodeoxyuridine438.3KRT14, VIM, KRT19, KRT1, DES, S100B
29thymidine43 249.2GFAP, S100B, KRT19, CEACAM3, DES, MUC1
30aspartate438.1CEACAM3, VIM, S100B, GFAP, KRT1, KRT19
31steroid438.1S100B, KRT1, ESR1, DES, CEACAM3, KRT19
32lactate438.1CEACAM3, VIM, S100B, KRT19, DES, GFAP
33testosterone43 59 24 1211.0GFAP, VIM, DES, KRT19, KRT1, S100B
34glycogen43 249.0VIM, GFAP, DES, MUC1, S100A1, S100B
35oxygen43 248.9KRT19, CEACAM3, MUC1, GFAP, DES, S100B
36serine437.9MUC1, GFAP, DES, KRT19, VIM, KRT1
37iron43 248.9GFAP, KRT14, DES, S100B, S100A1, VIM
38creatinine437.8DES, GFAP, VIM, MUC1, S100B, CEACAM3
39glucose437.8DES, GFAP, MUC1, S100B, KRT14, KRT19
40mucicarmine437.7CEACAM3, MUC1, VIM, DES, S100B, KRT14
41cysteine437.6DES, GFAP, VIM, S100A1, DAND5, KRT14
42b 723437.5DES, VIM, MUC1, CEACAM3, S100A1, S100B
43vegf437.5CEACAM3, MUC1, VIM, S100B, GFAP, DES
44retinoic acid43 248.0KRT19, KRT1, KRT14, DES, S100B, S100A1
45tyrosine437.0DES, KRT19, GFAP, KRT1, KRT14, S100B
46calcium43 49 24 129.9GFAP, DES, MUC1, CEACAM3, S100A1, S100B
47hematoxylin436.5GFAP, KRT19, KRT1, KRT14, DES, S100B
48paraffin436.2GFAP, DES, ESR1, VIM, KRT19, KRT1
49estrogen436.2DES, GFAP, ESR1, MUC1, CEACAM3, S100A1
50progesterone43 28 59 24 1210.2KRT14, S100B, S100A1, CEACAM3, DES, MUC1

GO Terms for genes affiliated with Syringoma

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Cellular components related to Syringoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell peripheryGO:00719449.2KRT19, KRT14
2Z discGO:00300188.9DES, S100A1, KRT19
3extracellular vesicular exosomeGO:00700628.5KRT19, KRT1, KRT14, MUC1, VIM
4intermediate filamentGO:00058828.4KRT19, KRT14, VIM, GFAP, DES

Biological processes related to Syringoma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1long-term synaptic potentiationGO:00602919.9GFAP, S100B
2Bergmann glial cell differentiationGO:00600209.8VIM, GFAP
3astrocyte developmentGO:00140029.8VIM, GFAP
4intermediate filament organizationGO:00451099.8VIM, GFAP
5muscle filament slidingGO:00300499.6VIM, DES
6negative regulation of neuron projection developmentGO:00109779.6VIM, GFAP
7regulation of heart contractionGO:00080169.2S100A1, DES

Molecular functions related to Syringoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1calcium-dependent protein bindingGO:00483069.6S100B, S100A1
2S100 protein bindingGO:00445489.3S100B, S100A1
3structural constituent of cytoskeletonGO:00052008.5KRT19, KRT14, VIM, GFAP, DES
4identical protein bindingGO:00428028.4DES, ESR1, VIM, S100A1, S100B
5protein bindingGO:00055156.8DES, ESR1, VIM, MUC1, S100A1, S100B

Products for genes affiliated with Syringoma

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Sources for Syringoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet