MCID: SYR003
MIFTS: 55

Syringoma malady

Rare diseases, Cancer diseases, Skin diseases categories
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Summaries for Syringoma

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NIH Rare Diseases:42 Syringomas are firm yellowish, translucent, or skin colored papules that are often found on the face, particularly around the eyes. they may occur suddenly in crops or multiples. they arise from the sweat ducts. they usually cause no symptoms. they are not associated with underlying abnormality. they are found more commonly in caucasians, and in females at puberty or near middle-age. last updated: 8/6/2009

MalaCards based summary: Syringoma, also known as syringoma nos, is related to hidradenoma and adenoma. An important gene associated with Syringoma is KRT1 (keratin 1), and among its related pathways are Aurora B signaling and Signaling mediated by p38-alpha and p38-beta. The compounds orcein and eosin have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and bone, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Wikipedia:65 Syringomas are harmless sweat duct tumors, typically found clustered on eyelids, although they may also... more...

Aliases & Classifications for Syringoma

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Syringoma, Aliases & Descriptions:

Name: Syringoma 8 42 10 44 62
 
Syringoma Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology8 DOID:2065
NCIt39 C3761
MeSH34 D018252

Related Diseases for Syringoma

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Diseases in the Syringoma family:

Malignant Syringoma

Diseases related to Syringoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1hidradenoma30.7MUC1
2adenoma30.0MUC1, CEACAM3, S100A1, KRT14, KRT19
3pleomorphic adenoma29.3DES, GFAP, VIM, MUC1, S100A1, S100B
4adenocarcinoma28.8ESR1, VIM, MUC1, CEACAM3, KRT14, KRT1
5vulvar syringoma10.5
6eccrine porocarcinoma10.5MUC1
7nephrogenic adenoma10.5S100A1
8subependymal giant cell astrocytoma10.5GFAP
9giant cell glioblastoma10.5GFAP
10mixed glioma10.5GFAP
11rosai-dorfman disease10.5S100B
12neurilemmoma10.5GFAP
13adenomatoid tumor10.5VIM
14fibrous meningioma10.4MUC1, S100B
15infantile myofibromatosis10.4DES
16langerhans-cell histiocytosis10.4S100A1, S100B
17cystadenocarcinoma10.4MUC1, CEACAM3
18mucinous cystadenocarcinoma10.3CEACAM3, MUC1
19myxopapillary ependymoma10.3GFAP, S100B
20cutaneous paget's disease10.3MUC1, CEACAM3
21papillary ependymoma10.3GFAP, S100B
22choroid plexus carcinoma10.3GFAP, S100B
23thymus cancer10.3MUC1, CEACAM3
24gemistocytic astrocytoma10.3GFAP, S100B
25diabetes mellitus10.3
26malignant syringoma10.3
27pineocytoma10.3S100B, GFAP
28clear cell ependymoma10.3VIM, MUC1
29epithelial-myoepithelial carcinoma10.3KRT14
30mammary paget's disease10.3MUC1, ESR1
31ganglioglioma10.3GFAP, S100B
32rhabdoid meningioma10.3GFAP, VIM
33malignant pleural mesothelioma10.3MUC1, CEACAM3
34astroblastoma10.3GFAP, VIM
35secretory meningioma10.3VIM, MUC1
36gastrointestinal carcinoma10.3CEACAM3, KRT19
37desmoplastic small round cell tumor10.3DES, MUC1
38ganglioneuroma10.3GFAP, S100B
39adenosquamous carcinoma10.2MUC1, KRT19
40tubular adenocarcinoma10.2ESR1, MUC1
41choroid plexus papilloma10.2GFAP, MUC1, S100B
42anaplastic ependymoma10.2GFAP, MUC1, S100B
43hemangioblastoma10.2GFAP, MUC1, S100B
44paraganglioma10.2GFAP, S100A1, S100B
45papillary thyroid carcinoma10.2KRT19, KRT1, S100A1
46lipoma10.2DES, S100A1
47malignant mixed mullerian tumor10.2ESR1, VIM
48chondroid syringoma of the vulva10.2
49syringocystadenoma papilliferum10.2
50pilocytic astrocytoma10.2GFAP, S100B

Graphical network of the top 20 diseases related to Syringoma:



Diseases related to syringoma

Symptoms for Syringoma

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Drugs & Therapeutics for Syringoma

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Drug clinical trials:

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Genetic Tests for Syringoma

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Anatomical Context for Syringoma

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MalaCards organs/tissues related to Syringoma:

32
Skin, Eye, Bone, Salivary gland, Lymph node, Breast

Animal Models for Syringoma or affiliated genes

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MGI Mouse Phenotypes related to Syringoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9KRT19, KRT14, MUC1, ESR1
2MP:00053818.7GFAP, ESR1, MUC1, KRT14, KRT19
3MP:00107718.5ESR1, MUC1, S100B, KRT14, KRT1, KRT19
4MP:00053698.4DES, GFAP, ESR1, VIM, S100A1
5MP:00028738.1GFAP, MUC1, S100A1, S100B, KRT19
6MP:00053768.1DES, GFAP, ESR1, VIM, MUC1, KRT14
7MP:00053868.0DES, GFAP, ESR1, VIM, S100A1, S100B
8MP:00053787.8DAND5, GFAP, ESR1, VIM, KRT14, KRT1
9MP:00107687.4DAND5, DES, GFAP, ESR1, VIM, KRT14
10MP:00053857.3KRT19, DAND5, DES, GFAP, ESR1, VIM

Publications for Syringoma

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Articles related to Syringoma:

(show top 50)    (show all 318)
idTitleAuthorsYear
1
Chondroid syringoma with extensive osseous differentiation: a rare finding. (24943789)
2014
2
Chondroid syringoma of the medial canthus. (24744935)
2014
3
A curious serendipitous finding: Spitz naevus combined with a syringoma. (22671019)
2013
4
Penile syringoma: reports and review of patients with syringoma located on the penis. (23882308)
2013
5
Giant chondroid syringoma of the eyelid. (23931483)
2013
6
Facial localization of malignant chondroid syringoma: a rare case report. (23476847)
2013
7
Eruptive milium-like syringoma showing eccrine duct origin of milia. (22150478)
2012
8
Mohs micrographic surgery for recurrent chondroid syringoma of the eyebrow. (22309155)
2012
9
Commentary: treatment of syringoma using an ablative 10,600-nm carbon dioxide fractional laser. (21481062)
2011
10
Chondroid syringoma of the scalp: case report and discussion of clinical features, histopathology, and treatment. (21500172)
2011
11
Malignant chondroid syringoma: report of a case with lymph node metastasis 12 years after local excision. (21971270)
2011
12
Eruptive widespread papular eruption on the abdomen: a quiz. Clear cell syringoma, eruptive variant. (21264456)
2011
13
Autosomal dominant multiple syringomas linked to chromosome 16q22. (20132207)
2010
14
Eruptive syringoma associated with hyperthyroidism. (20527152)
2010
15
Milia with calcium deposits on the palms and soles in a patient with multiple syringoma. (20653855)
2010
16
Autoimmune acrosyringitis with ductal cysts: reclassification of case of eruptive syringoma. (19522848)
2009
17
Chondroid syringoma: a rare tumor of orofacial region. (19633639)
2009
18
Preoperative cytologic diagnosis of chondroid syringoma. (19798896)
2009
19
Eruptive syringoma developed over a waxing skin area. (18645310)
2008
20
Syringoma-like eccrine sweat duct proliferation induced by radiation. (16469082)
2006
21
Periorbital syringoma: a pilot study of the efficacy of low-voltage electrocoagulation. (17034373)
2006
22
A rare case of chondroid syringoma arising from the lower eyelid with ectropion. (17051093)
2006
23
Elevated levels of serum carcinoembryonic antigen in a patient with eruptive syringoma. (16112373)
2005
24
Eruptive syringoma in four Black South African children. (15550160)
2004
25
Chondroid syringoma. Cytokeratin 20 immunolocalization of Merkel cells and reappraisal of apocrine folliculo-sebaceous differentiation. (15335266)
2004
26
Chondroid syringoma of the upper lip: a case report. (16027488)
2004
27
Cutaneous benign mixed tumor (chondroid syringoma) of the eyelid: clinical presentation and management. (15083078)
2004
28
Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma, spiradenoma, and syringoma. (14739501)
2004
29
Multiple syringomas in an unusual distribution. (14673269)
2003
30
Chondroid syringoma. A case report. (12038117)
2002
31
High-dose-rate endobronchial brachytherapy in endobronchial metastatic malignant chondroid syringoma. (11464090)
2001
32
Vulvar syringoma causing pruritus and carcinophobia: treatment by argon laser. (11360416)
1999
33
Chondroid syringoma: an immunohistochemical study using antibodies to Ca 15-3, KA-93, Ca 19-9, CD44 and BM-1. (9001983)
1996
34
Hyaline cell-rich chondroid syringoma: epithelial nature of the hyaline cells. (8765182)
1996
35
Milium-like syringoma in the perianal region. (8534946)
1995
36
Chondroid syringoma. A rare occurrence in the hallux. (8394420)
1993
37
Fine needle aspiration cytology of chondroid syringoma and syringocystadenoma papilliferum. A report of two cases. (8392255)
1993
38
Eruptive syringoma. (8388104)
1993
39
Subclinical syringoma coexisting with nevocellular nevus on the vulva. (8478501)
1993
40
Generalised eruptive syringoma--a papular dermatosis. (1965678)
1990
41
Syringoma presenting as milia. (3819065)
1987
42
Multiple penile papules. Syringoma. (3662576)
1987
43
Malignant chondroid syringoma. (2822351)
1987
44
Syringoma of the ankle. (6715599)
1984
45
Chondroid syringoma. (6100183)
1984
46
Syringoma of the forehead. (6840942)
1983
47
Acral syringoma: electron microscopic studies on its origin. (6175141)
1982
48
Chondroid syringoma (mixed tumour) of radius. (6266947)
1981
49
Ultrastructure of chondroid syringoma: role of the myoepithelial cell in the development of the mixed tumor of the skin and soft tissues. (222430)
1979
50
Metastasising chondroid syringoma. (4352760)
1973

Variations for Syringoma

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Expression for genes affiliated with Syringoma

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Expression patterns in normal tissues for genes affiliated with Syringoma

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Pathways for genes affiliated with Syringoma

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Compounds for genes affiliated with Syringoma

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Compounds related to Syringoma according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1orcein449.7VIM, S100B, DES
2eosin449.5MUC1, VIM, GFAP, S100B
3progestin449.3MUC1, VIM, ESR1, DES
42-methoxyethanol449.3VIM, S100A1, KRT14
5toluidine449.3S100A1, DES, VIM
6s 100449.2GFAP, DES, VIM, MUC1, S100B
7reticulin449.2MUC1, S100B, DES, VIM, GFAP
8dihydrotestosterone44 28 24 1112.2DES, MUC1, VIM, ESR1
9chloramphenicol44 2 50 1112.0MUC1, ESR1, VIM, S100B, KRT14
10hyaluronic acid44 2410.0VIM, MUC1, DES, KRT19
11methionine448.9KRT14, S100B, VIM, GFAP, DES
12biotin44 24 1110.9KRT1, S100A1, MUC1, VIM, DES
13proline448.8DES, VIM, S100B, KRT14, KRT1
14butyrate448.8KRT19, KRT14, MUC1, VIM, GFAP
15retinoid448.8KRT19, ESR1, KRT1, KRT14, VIM
16paclitaxel44 50 1110.8S100B, VIM, KRT19, ESR1, GFAP
17threonine448.7GFAP, DES, MUC1, KRT14, S100B, KRT1
18acth448.6S100B, CEACAM3, GFAP, MUC1
19acetylcholine44 50 28 24 1112.6S100B, S100A1, VIM, GFAP, DES
20formaldehyde44 249.6S100B, MUC1, VIM, GFAP, KRT19, DES
21cisplatin44 50 61 1111.6GFAP, MUC1, ESR1, KRT19, KRT14
22methotrexate50 44 1110.6MUC1, CEACAM3, VIM, ESR1
23arginine448.6KRT14, DES, GFAP, VIM, S100B, KRT1
24estradiol44 24 1110.6MUC1, KRT19, ESR1, VIM, GFAP, DES
25tamoxifen44 50 28 1111.5KRT14, ESR1, VIM, MUC1, CEACAM3
26cyclic amp44 249.4VIM, MUC1, GFAP, DES, S100B
27adriamycin448.4CEACAM3, KRT19, MUC1, VIM, DES
28bromodeoxyuridine448.3KRT14, VIM, KRT19, KRT1, DES, S100B
29thymidine44 249.2GFAP, S100B, KRT19, CEACAM3, DES, MUC1
30aspartate448.1CEACAM3, VIM, S100B, GFAP, KRT1, KRT19
31steroid448.1S100B, KRT1, ESR1, DES, CEACAM3, KRT19
32lactate448.1CEACAM3, VIM, S100B, KRT19, DES, GFAP
33testosterone44 61 24 1111.0GFAP, VIM, DES, KRT19, KRT1, S100B
34glycogen44 249.0VIM, GFAP, DES, MUC1, S100A1, S100B
35oxygen44 248.9KRT19, CEACAM3, MUC1, GFAP, DES, S100B
36serine447.9MUC1, GFAP, DES, KRT19, VIM, KRT1
37iron44 248.9GFAP, KRT14, DES, S100B, S100A1, VIM
38creatinine447.8DES, GFAP, VIM, MUC1, S100B, CEACAM3
39glucose447.8DES, GFAP, MUC1, S100B, KRT14, KRT19
40mucicarmine447.7CEACAM3, MUC1, VIM, DES, S100B, KRT14
41cysteine447.6DES, GFAP, VIM, S100A1, DAND5, KRT14
42b 723447.5DES, VIM, MUC1, CEACAM3, S100A1, S100B
43vegf447.5CEACAM3, MUC1, VIM, S100B, GFAP, DES
44retinoic acid44 248.0KRT19, KRT1, KRT14, DES, S100B, S100A1
45tyrosine447.0DES, KRT19, GFAP, KRT1, KRT14, S100B
46calcium44 50 24 119.9GFAP, DES, MUC1, CEACAM3, S100A1, S100B
47hematoxylin446.5GFAP, KRT19, KRT1, KRT14, DES, S100B
48paraffin446.2GFAP, DES, ESR1, VIM, KRT19, KRT1
49estrogen446.2DES, GFAP, ESR1, MUC1, CEACAM3, S100A1
50progesterone44 28 61 24 1110.2KRT14, S100B, S100A1, CEACAM3, DES, MUC1

GO Terms for genes affiliated with Syringoma

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Cellular components related to Syringoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell peripheryGO:0719449.2KRT19, KRT14
2Z discGO:0300188.9DES, S100A1, KRT19
3extracellular vesicular exosomeGO:0700628.5KRT19, KRT1, KRT14, MUC1, VIM
4intermediate filamentGO:0058828.4KRT19, KRT14, VIM, GFAP, DES

Biological processes related to Syringoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1long-term synaptic potentiationGO:0602919.9GFAP, S100B
2Bergmann glial cell differentiationGO:0600209.8VIM, GFAP
3astrocyte developmentGO:0140029.8VIM, GFAP
4intermediate filament organizationGO:0451099.8VIM, GFAP
5muscle filament slidingGO:0300499.6VIM, DES
6negative regulation of neuron projection developmentGO:0109779.6VIM, GFAP
7regulation of heart contractionGO:0080169.2S100A1, DES

Molecular functions related to Syringoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-dependent protein bindingGO:0483069.6S100B, S100A1
2S100 protein bindingGO:0445489.3S100B, S100A1
3structural constituent of cytoskeletonGO:0052008.5KRT19, KRT14, VIM, GFAP, DES
4identical protein bindingGO:0428028.4DES, ESR1, VIM, S100A1, S100B
5protein bindingGO:0055156.8DES, ESR1, VIM, MUC1, S100A1, S100B

Products for genes affiliated with Syringoma

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Sources for Syringoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet