MCID: SYS001
MIFTS: 83

Systemic Lupus Erythematosus malady

Summaries for Systemic Lupus Erythematosus

Sources:
8Disease Ontology, 3CDC, 44NINDS, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
CDC:3 Systemic Lupus Erythematosus is an autoimmune disease in which the immune system produces antibodies to cells within the body leading to widespread inflammation and tissue damage. The causes of SLE are unknown but are believed to be linked to genetic, environmental, and hormonal factors. SLE may be characterized by periods of illness and remissions. SLE has a variety of clinical manifestations and can affect joints, skin, brain, lungs, kidneys, and blood vessels. People with SLE may experience fatigue, pain or swelling in joints, skin rashes, and fevers. A team approach in treating lupus is often warranted due to the number of organ systems involved.

MalaCards: Systemic Lupus Erythematosus, also known as lupus erythematosus, systemic, is related to arthritis and lupus nephritis. An important gene associated with Systemic Lupus Erythematosus is TLR5 (toll-like receptor 5), and among its related pathways are Staphylococcus aureus infection and ErbB4 Pathway. The drugs triamcinolone and triamcinolone acetonide and the compounds calcium and phosphatidylinositol have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart.

NINDS:44 Lupus (also called ) is a disorder of the immune system. Normally, the immune system protects the body against invading infections and cancers. In lupus, the immune system is over-active and produces increased amounts of abnormal antibodies that attack the body's tissues and organs. Lupus can affect many parts of the body, including the joints, skin, kidneys, lungs, heart, nervous system, and blood vessels. The signs and symptoms of lupus differ from person to person; the disease can range from mild to life threatening.

Wikipedia:64 Systemic lupus erythematosus i/sɪˈstɛmɪk ˈluːpəs ˌɛrɪθiːməˈtoʊsəs/, often abbreviated to... more...

Description from OMIM:47 152700,601744

Aliases & Classifications for Systemic Lupus Erythematosus

Sources:
8Disease Ontology, 44NINDS, 47OMIM, 10DISEASES, 31LifeMap Discovery™, 22GTR, 61UMLS, 45Novoseek, 57SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:



Aliases & Descriptions:

systemic lupus erythematosus 8 44 47 10 31
lupus erythematosus, systemic 8 22 61
sle - lupus erythematosus, systemic 8
disseminated lupus erythematosus 8
lupus erythematosus systemic 45


External Ids:

Disease Ontology8 DOID:9074
NCIt40 C3201
MeSH35 D008180
OMIM47 152700
ICD9CM27 710.0
ICD1025 M32, M32.1

Related Diseases for Systemic Lupus Erythematosus

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Systemic Lupus Erythematosus family:

lupus erythematosus cr2-related susceptibility to systemic lupus erythematosus
systemic lupus erythematosus 14 systemic lupus erythematosus 9
systemic lupus erythematosus 1 systemic lupus erythematosus with nephritis 2
systemic lupus erythematosus 2 systemic lupus erythematosus 16
systemic lupus erythematosus 3 systemic lupus erythematosus 13
systemic lupus erythematosus 10 systemic lupus erythematosus 12
systemic lupus erythematosus with nephritis 1 systemic lupus erythematosus with nephritis 3
systemic lupus erythematosus with hemolytic anemia systemic lupus erythematosus 4
systemic lupus erythematosus 5 systemic lupus erythematosus 7
systemic lupus erythematosus 8

Diseases related to Systemic Lupus Erythematosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 632)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.8C3, PTPN22, CTLA4, FCGR2B, FCGR3A
2lupus nephritis31.6FCGR3A, DNASE1
3nephritis31.6C3, FCGR3A, C4A
4vasculitis31.4CTLA4, C3
5thrombocytopenia31.1FCGR2B, FCGR3A
6tuberculosis31.0C3, DNASE1
7sjogren's syndrome30.9FASLG
8thyroiditis30.8FASLG, CTLA4, PTPN22
9hepatitis b30.7DNASE1
10acute myocardial infarction30.6DNASE1
11celiac disease30.6PTPN22, CTLA4
12sepsis30.5C3, FCGR3A, C4A, TLR5
13asthma30.5DNASE1, STAT4, CTLA4
14graves' disease30.4FASLG, CTLA4, FCRL3, PTPN22
15autoimmune thyroiditis30.4FASLG, CTLA4, PTPN22
16vitiligo30.4PTPN22, C4B, CTLA4
17wegener's granulomatosis30.4CTLA4
18burkitt's lymphoma30.1FCGR2B, CR2, FASLG
19pediatric systemic lupus erythematosus11.1
20antiphospholipid syndrome11.1
21systemic lupus erythematosus 111.0
22bullous systemic lupus erythematosus11.0
23myelitis11.0
24n syndrome11.0
25atherosclerosis10.9
26protein-losing enteropathy10.9
27cutaneous lupus erythematosus10.9
28mixed connective tissue disease10.9
29transverse myelitis10.9
30systemic scleroderma10.9
31systemic lupus erythematosus 210.8
32discoid lupus erythematosus10.8
33hepatitis e10.8
34klinefelter's syndrome10.7
35thrombotic thrombocytopenic purpura10.7
36hepatitis a10.7
37vascular disease10.7
38neonatal systemic lupus erythematosus10.7
39rheumatic disease10.7
40cardiac tamponade10.7
41congenital heart block10.7
42hepatitis c10.7
43arthropathy10.7
44diffuse alveolar hemorrhage10.7
45juvenile rheumatoid arthritis10.6
46autoimmune hepatitis10.6
47systemic lupus erythematosus 310.6
48membranous glomerulonephritis10.6
49osteonecrosis10.6
50hyperprolactinemia10.6

Graphical network of the top 20 diseases related to Systemic Lupus Erythematosus:



Diseases related to systemic lupus erythematosus

Clinical Features for Systemic Lupus Erythematosus

Sources:
47OMIM
See all sources

Clinical features from OMIM:

152700,601744

Clinical synopsis from OMIM:

152700

Drugs & Therapeutics for Systemic Lupus Erythematosus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Systemic Lupus Erythematosus

Drug clinical trials:

Search ClinicalTrials for Systemic Lupus Erythematosus

Search NIH Clinical Center for Systemic Lupus Erythematosus

Search CenterWatch for Systemic Lupus Erythematosus

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Systemic Lupus Erythematosus cell therapies at LifeMap Discovery.

Genetic Tests for Systemic Lupus Erythematosus

Sources:
22GTR
See all sources

Genetic tests related to Systemic Lupus Erythematosus:

id Genetic test Affiliating Genes
1 Systemic Lupus Erythematosus22

Anatomical Context for Systemic Lupus Erythematosus

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Systemic Lupus Erythematosus:

33
Skin, Liver, Spinal cord, Brain, Kidney, Lung, Spleen, Uterus, Bone marrow, Whole blood, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Thyroid, Salivary gland, Adrenal gland, Breast, Placenta, Prostate, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal brain, Parietal lobe, Temporal lobe, Atrioventricular node, Fetal liver, Fetal lung, Fetal thyroid, Pineal, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Systemic Lupus Erythematosus:
id TissueAnatomical CompartmentCell Relevance
1 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Systemic Lupus Erythematosus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Systemic Lupus Erythematosus

Sources:
51PubMed
See all sources

Articles related to Systemic Lupus Erythematosus:

(show top 50)    (show all 4413)
idTitleAuthorsYear
1
High levels of uric acid in systemic lupus erythematosus is associated with pulmonary hypertension. (24428867)
2014
2
Association of RANTES and MBL gene polymorphisms with systemic lupus erythematosus: a meta-analysis. (23065234)
2013
3
B-cell-targeted therapies in systemic lupus erythematosus and ANCA-associated vasculitis: current progress. (23971754)
2013
4
Successful rituximab treatment of refractory hemophagocytic lymphohistiocytosis and autoimmune hemolytic anemia associated with systemic lupus erythematosus. (23389337)
2013
5
Resolution of neuropsychological and FDG-PET abnormalities in a patient with neuropsychiatric systemic lupus erythematosus. (24077576)
2013
6
Glucocorticoid downregulates expression of IL-12 family cytokines in systemic lupus erythematosus patients. (23884985)
2013
7
Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of cigarette smoking and systemic lupus erythematosus in a Japanese population. (22217397)
2012
8
Determining risk factors for developing systemic lupus erythematosus in patients with discoid lupus erythematosus. (21910708)
2012
9
Expression and significance of leukocyte membrane cofactor protein transcript in systemic lupus erythematosus. (22247341)
2012
10
PPARI^ expression is increased in systemic lupus erythematosus patients and represses CD40/CD40L signaling pathway. (21415255)
2011
11
CD5 expression in B cells from patients with systemic lupus erythematosus. (21395509)
2011
12
Cerebral toxoplasmosis in systemic lupus erythematosus following intravenous methylprednisolone. (23765150)
2011
13
Oxidative protein damage and antioxidant status in systemic lupus erythematosus. (19874339)
2010
14
Oxidative stress in systemic lupus erythematosus: relationship to Th1 cytokine and disease activity. (20105444)
2010
15
Fcgamma receptor IIB and IIIB polymorphisms and susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysis. (19502269)
2009
16
Hypovitaminosis D is associated with greater body mass index and disease activity in pediatric systemic lupus erythematosus. (19446841)
2009
17
Thrombotic events in systemic lupus erythematosus. Its association with acquired and inherited thrombophilic defects. (19029633)
2008
18
Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (18174230)
2008
19
C-reactive protein and cognitive deficits in systemic lupus erythematosus. (17356342)
2007
20
Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus. (16719905)
2006
21
A mutation of the glucocorticoid receptor gene in patients with systemic lupus erythematosus. (15212141)
2004
22
Increased serum matrix metalloproteinase 9 levels in systemic lupus erythematosus patients with neuropsychiatric manifestations and brain magnetic resonance imaging abnormalities. (15022328)
2004
23
The R-H polymorphism of FCgamma receptor IIa as a risk factor for systemic lupus erythematosus is independent of single-nucleotide polymorphisms in the interleukin-10 gene promoter. (11953994)
2002
24
Acute intermittent porphyria and systemic lupus erythematosus: report of a case and review of the literature. (11999885)
2002
25
Lack of association between arylamine N-acetyltransferase 2 (NAT2) polymorphism and systemic lupus erythematosus. (12360107)
2002
26
Involuntary movement disorders as first manifestation of systemic lupus erythematosus: case report]. (11588646)
2001
27
Presence of four major haplotypes in human BCMA gene: lack of association with systemic lupus erythematosus and rheumatoid arthritis. (11528522)
2001
28
Prolactin levels and autoantibodies in female patients with systemic lupus erythematosus. (11155810)
2000
29
Anticardiolipin and anti-beta2glycoprotein-I antibodies in patients with systemic lupus erythematosus: comparison between Colombians and Spaniards. (10192508)
1999
30
Retroperitoneal fibrosis and systemic lupus erythematosus. (10344387)
1999
31
Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis. (9704652)
1998
32
Ro/SS-A and La/SS-B antibody level variation in patients with SjAPgren's syndrome and systemic lupus erythematosus. (9480721)
1998
33
Abnormalities in CD69 expression, cytosolic pH and Ca2+ during activation of lymphocytes from patients with systemic lupus erythematosus. (9116719)
1997
34
Urinary excretion of albumin and retinol binding protein in systemic lupus erythematosus. (9367006)
1997
35
Factor V:Q506 mutation and anticardiolipin antibodies in systemic lupus erythematosus. (9116703)
1996
36
Acquired free protein S deficiency is associated with antiphospholipid antibodies and increased thrombin generation in patients with systemic lupus erythematosus. (7709951)
1995
37
Increased levels of intercellular adhesion molecule-1 in the serum of patients with systemic lupus erythematosus. (7909280)
1994
38
Polymorphism of the tumor necrosis factor beta gene in systemic lupus erythematosus: TNFB-MHC haplotypes. (8436420)
1993
39
Similar frequency of autoantibodies against 70-kD class heat-shock proteins in healthy subjects and systemic lupus erythematosus patients. (8467563)
1993
40
Pancreatitis related to antiphospholipid antibody syndrome in a patient with systemic lupus erythematosus. (1512770)
1992
41
T lymphocyte expression of complement receptor 2 (CR2/CD21): a role in adhesive cell-cell interactions and dysregulation in a patient with systemic lupus erythematosus (SLE). (1424280)
1992
42
The molecular genetics of systemic lupus erythematosus and SjAPgren's syndrome. (1419498)
1992
43
Isolation and characterization of a thermolabile beta-2 macroglycoprotein ('thermolabile substance' or 'Hakata antigen') detected by precipitating (auto) antibody in sera of patients with systemic lupus erythematosus. (1859827)
1991
44
Plasma lactoferrin and neutrophil elastase in rheumatoid arthritis and systemic lupus erythematosus. (2306568)
1990
45
Lack of gene deletion for complement C4A deficiency in Japanese patients with systemic lupus erythematosus. (1976809)
1990
46
Anti-Ro(SSA) autoantibodies are associated with T cell receptor beta genes in systemic lupus erythematosus patients. (1967259)
1990
47
Studies of peritoneal macrophage function in murine systemic lupus erythematosus. 2. Nature of elevated resident peritoneal cells in NZB and (NZB x NZW)F1 mice. (3861745)
1985
48
Multiple mononeuropathy as the initial presentation of systemic lupus erythematosus--nerve biopsy and response to plasma exchange. (6188811)
1982
49
Systemic lupus erythematosus and malignant histiocytosis. (82801)
1978
50
BILATERAL BAND-SHAPED DEEP KERATITIS AND IRIDOCYCLITIS IN SYSTEMIC LUPUS ERYTHEMATOSUS. (18170862)
1964

Genetic Variations for Systemic Lupus Erythematosus

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Systemic Lupus Erythematosus:

63
id Symbol AA change Variation SNP ID
1TREX1p.Arg169HisVAR_028319
2TREX1p.Ala213ValVAR_037949
3TREX1p.Gly282SerVAR_037950rs113107733
4TREX1p.Arg295SerVAR_037951rs72556555
5TREX1p.Ala302ProVAR_037952rs112741962
6TREX1p.Pro345LeuVAR_037954
7TREX1p.Tyr360CysVAR_037955
8TREX1p.Gly361AlaVAR_037956

Expression for genes affiliated with Systemic Lupus Erythematosus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Systemic Lupus Erythematosus

Search GEO for disease gene expression data for Systemic Lupus Erythematosus.

Pathways for genes affiliated with Systemic Lupus Erythematosus

Sources:
30KEGG, 52QIAGEN, 12EMD Millipore, 38NCBI BioSystems Database, 54Reactome, 56SinoBiological
See all sources

Pathways related to Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.4C3, FCGR3A, FCGR2B, C4B, C4A
2
Hide members
11.2FCGR2B, STAT4, CR2, TLR5
3
Hide members
11.2FCGR3A, FCGR2B, CR2, FASLG
4
Hide members
11.2C3, CR2, C4B, C4A
5
Immune response Lectin induced complement pathway
Hide members
11.2C4A, C4B, CR2, C3
6
Hide members
11.2C4A, C4B, CR2, C3
7
Hide members
11.2TLR5, FASLG, STAT4, C3
8
Hide members
11.2C4A, C4B, FCGR3A, C3
9
Hide members
11.2TLR5, STAT4, FCGR3A, C3
1011.0C4A, C4B, C3
11
Hide members
11.0FCGR2B, FCGR3A, C3
1210.9C3, C4A

Compounds for genes affiliated with Systemic Lupus Erythematosus

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR
See all sources

Compounds related to Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2415.5TNFRSF13C, FASLG, CTLA4, C4B, CR2, DNASE1
2phosphatidylinositol4512.3TLR5, FASLG, CTLA4, CR2, STAT4, FCGR2B
3tyrosine4512.3TLR5, FASLG, CTLA4, CR2, STAT4, FCGR2B
4estrogen4511.9FASLG, CTLA4, CR2, DNASE1, FCGR2B, C3
5Intravenous Immunoglobulin1111.8C3, FCGR3A, FCGR2B, C4B, C4A
6agarose4511.8FASLG, C4A, C4B, DNASE1, C3
7rituximab45 50 1113.6FASLG, CTLA4, FCGR2B, FCGR3A
8serine4511.4C3, FCGR2B, CTLA4
9ivig4511.4FASLG, FCGR2B, FCGR3A
10paraffin4511.2DNASE1L3, DNASE1, CR2, FASLG
11Palivizumab1111.2FCGR3A, FCGR2B
12Ibritumomab1111.1FCGR2B, FCGR3A
13bevacizumab50 1112.1FCGR2B, FCGR3A
14dexamethasone45 50 29 1114.1FASLG, CTLA4, STAT4, DNASE1, C3
15tositumomab50 1112.1FCGR2B, FCGR3A
16alefacept45 1112.1FCGR3A, FCGR2B
17Muromonab1111.1FCGR2B, FCGR3A
18efalizumab45 1112.1FCGR2B, FCGR3A
19aurintricarboxylic acid4511.0DNASE1, DNASE1L3
20daclizumab45 1112.0FCGR3A, FCGR2B
21basiliximab45 1112.0FCGR2B, FCGR3A
22gemtuzumab ozogamicin45 1111.9FCGR3A, FCGR2B
23natalizumab45 1111.9FCGR2B, FCGR3A
24alemtuzumab45 1111.8FCGR2B, FCGR3A

GO Terms for genes affiliated with Systemic Lupus Erythematosus

Sources:
16Gene Ontology
See all sources

Cellular components related to Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989711.4FCGR3A, CR2, CTLA4, FASLG, TNFRSF13C

Biological processes related to Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508711.9TLR5, C4A, C4B, CR2, TREX1, FCGR3A
2immune responseGO:00695511.7FASLG, CTLA4, CR2, FCGR2B, FCGR3A, C3
3complement activation, classical pathwayGO:00695811.4C3, CR2, C4B, C4A
4inflammatory responseGO:00695411.2C3, C4B, C4A, TLR5
5regulation of complement activationGO:03044911.0C3, C4B, C4A
6complement activationGO:00695610.9C4A, C4B, C3
7regulation of immune responseGO:05077610.7C3, FCGR3A, FCGR2B

Molecular functions related to Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:01986410.9FCGR3A, FCGR2B
2endopeptidase inhibitor activityGO:00486610.7C3, C4B, C4A

Products for genes affiliated with Systemic Lupus Erythematosus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Systemic Lupus Erythematosus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet