SLE
MCID: SYS001
MIFTS: 89

Systemic Lupus Erythematosus (SLE) malady

Genetic diseases, Immune diseases, Rare diseases, Skin diseases, Bone diseases categories

Summaries for Systemic Lupus Erythematosus

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OMIM:46 Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies... (152700) more...

MalaCards based summary: Systemic Lupus Erythematosus, also known as disseminated lupus erythematosus, is related to lupus erythematosus and arthritis, and has symptoms including autosomal dominant inheritance, nephritis and psychosis. An important gene associated with Systemic Lupus Erythematosus is TLR5 (toll-like receptor 5), and among its related pathways are Leishmaniasis and Toll-like receptor signaling pathway. The drugs dehydroepiandrosterone and azathioprine and the compounds agarose and anaphylatoxin have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and kidney, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Disease Ontology:9 A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart.

Genetics Home Reference:22 Systemic lupus erythematosus (SLE) is a chronic disease that causes inflammation in connective tissues, such as cartilage and the lining of blood vessels, which provide strength and flexibility to structures throughout the body. The signs and symptoms of SLE vary among affected individuals, and can involve many organs and systems, including the skin, joints, kidneys, lungs, central nervous system, and blood-forming (hematopoietic) system. SLE is one of a large group of conditions called autoimmune disorders that occur when the immune system attacks the body's own tissues and organs.

CDC:4 Systemic Lupus Erythematosus is an autoimmune disease in which the immune system produces antibodies to cells within the body leading to widespread inflammation and tissue damage. The causes of SLE are unknown but are believed to be linked to genetic, environmental, and hormonal factors. SLE may be characterized by periods of illness and remissions. SLE has a variety of clinical manifestations and can affect joints, skin, brain, lungs, kidneys, and blood vessels. People with SLE may experience fatigue, pain or swelling in joints, skin rashes, and fevers. A team approach in treating lupus is often warranted due to the number of organ systems involved.

NINDS:43 Lupus (also called ) is a disorder of the immune system. Normally, the immune system protects the body against invading infections and cancers. In lupus, the immune system is over-active and produces increased amounts of abnormal antibodies that attack the body's tissues and organs. Lupus can affect many parts of the body, including the joints, skin, kidneys, lungs, heart, nervous system, and blood vessels. The signs and symptoms of lupus differ from person to person; the disease can range from mild to life threatening.

Wikipedia:64 Systemic lupus erythematosus i/s??st?m?k ?lu?p?s ??r??i?m??to?s?s/, often abbreviated as SLE or lupus,... more...

Description from OMIM:46 601744

Aliases & Classifications for Systemic Lupus Erythematosus

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Systemic Lupus Erythematosus, Aliases & Descriptions:

Name: Systemic Lupus Erythematosus 31 9 22 43 46 11
Disseminated Lupus Erythematosus 9 22 61
Lupus Erythematosus, Systemic 9 23 61
Libman-Sacks Disease 22 61
Le Syndrome 22 61
 
Lupus 22 61
Sle - Lupus Erythematosus, Systemic 9
Lupus Erythematosus Systemic 44
Sle Nos 61
Sle 22


Classifications:



External Ids:

Disease Ontology9 DOID:9074
NCIt39 C3201
ICD9CM28 710.0
OMIM46 152700
MeSH34 D008180
ICD1026 M32, M32.1

Related Diseases for Systemic Lupus Erythematosus

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Diseases in the Systemic Lupus Erythematosus family:

Lupus Erythematosus Dnase1-Related Susceptibility to Systemic Lupus Erythematosus
Cr2-Related Susceptibility to Systemic Lupus Erythematosus Systemic Lupus Erythematosus 14
Systemic Lupus Erythematosus 9 Systemic Lupus Erythematosus 1
Systemic Lupus Erythematosus 2 Systemic Lupus Erythematosus 16
Systemic Lupus Erythematosus 3 Systemic Lupus Erythematosus 13
Systemic Lupus Erythematosus 10 Systemic Lupus Erythematosus 12
Systemic Lupus Erythematosus 4 Systemic Lupus Erythematosus 5
Systemic Lupus Erythematosus 7 Systemic Lupus Erythematosus 8

Diseases related to Systemic Lupus Erythematosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 957)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus33.7TREX1, C4A, C3, DNASE1, FCGR2B
2arthritis32.6PTPN22, C3, FCGR2B
3rheumatoid arthritis32.6STAT4, PDCD1, PTPN22, FCGR2B, C3
4connective tissue disease32.1TREX1, DNASE1, FCGR2B, PTPN22, C3
5multiple sclerosis31.8C4B, PDCD1, STAT4, PTPN22
6complement deficiency31.7C4A, C3
7type 1 diabetes mellitus31.3PTPN22, C3, C4A, PDCD1
8sepsis31.2C3, TLR5, C4A
9burkitt's lymphoma30.9CR2, STAT4, FCGR2B, DNASE1, PDCD1
10vitiligo30.9C4B, PTPN22
11inflammatory bowel disease30.8STAT4, TLR5, PTPN22
12pediatric systemic lupus erythematosus11.1
13nephritis11.1
14antiphospholipid syndrome11.1
15bullous systemic lupus erythematosus11.0
16systemic lupus erythematosus, association with11.0
17myelitis11.0
18endotheliitis11.0
19vasculitis11.0
20lupus nephritis11.0
21atherosclerosis10.9
22protein-losing enteropathy10.9
23transverse myelitis10.9
24mixed connective tissue disease10.9
25purpura10.9
26scleroderma10.9
27glomerulonephritis10.9
28cerebritis10.9
29hypertension10.9
30hepatitis10.8
31retinitis10.8
32lymphopenia10.8
33thyroiditis10.8
34thrombocytopenia10.8
35discoid lupus erythematosus10.8
36thrombotic thrombocytopenic purpura10.8
37klinefelter's syndrome10.8
38pure red-cell aplasia10.7
39dermatomyositis10.7
40diffuse alveolar hemorrhage10.7
41intestinal pseudo-obstruction10.7
42cutaneous lupus erythematosus10.7
43aneurysm10.7
44cardiac tamponade10.7
45meningitis10.7
46pneumonia10.7
47tuberculosis10.7
48congenital heart block10.7
49myocardial infarction10.7
50arthropathy10.7

Graphical network of the top 20 diseases related to Systemic Lupus Erythematosus:



Diseases related to systemic lupus erythematosus

Symptoms for Systemic Lupus Erythematosus

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Symptoms by clinical synopsis from OMIM:

152700

Clinical features from OMIM:

152700,601744

HPO human phenotypes related to Systemic Lupus Erythematosus:

(show all 14)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 nephritis HP:0000123
3 psychosis HP:0000709
4 cutaneous photosensitivity HP:0000992
5 seizures HP:0001250
6 arthritis HP:0001369
7 pericarditis HP:0001701
8 thrombocytopenia HP:0001873
9 hemolytic anemia HP:0001878
10 leukopenia HP:0001882
11 pleuritis HP:0002102
12 systemic lupus erythematosus HP:0002725
13 antinuclear antibody positivity HP:0003493
14 antiphospholipid antibody positivity HP:0003613

Drugs & Therapeutics for Systemic Lupus Erythematosus

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Drug clinical trials:

Search ClinicalTrials for Systemic Lupus Erythematosus

Search NIH Clinical Center for Systemic Lupus Erythematosus

Inferred drug relations via UMLS61/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Systemic Lupus Erythematosus cell therapies at LifeMap Discovery.

Genetic Tests for Systemic Lupus Erythematosus

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Genetic tests related to Systemic Lupus Erythematosus:

id Genetic test Affiliating Genes
1 Systemic Lupus Erythematosus23

Anatomical Context for Systemic Lupus Erythematosus

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MalaCards organs/tissues related to Systemic Lupus Erythematosus:

32
T cells, Skin, Kidney, B cells, Lung, Heart, Endothelial, Brain, Neutrophil, Monocytes, Bone, Thyroid, Liver, Testes, Bone marrow, Breast, Pituitary, Myeloid, Whole blood, Spleen, Nk cells, Spinal cord, Placenta, Eye, Skeletal muscle, Colon, Salivary gland, Uterus, Prostate, Temporal lobe, Pineal, Smooth muscle

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Systemic Lupus Erythematosus:
id TissueAnatomical CompartmentCell Relevance
1 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Systemic Lupus Erythematosus or affiliated genes

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MGI Mouse Phenotypes related to Systemic Lupus Erythematosus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.5TREX1, PTPN22, FCGR2B, STAT4, DNASE1, C3
2MP:000537010.4TLR5, PTPN22, FCGR2B, C3, PDCD1, C4B
3MP:000539710.4TLR5, PTPN22, FCGR2B, STAT4, DNASE1, C3
4MP:000538710.4STAT4, FCGR2B, PTPN22, TLR5, DNASE1, C3
5MP:000537610.4TLR5, PTPN22, FCGR2B, STAT4, DNASE1, C3
6MP:000538110.4TLR5, PTPN22, FCGR2B, C3, C4B, TREX1
7MP:000537910.4PTPN22, FCGR2B, STAT4, C3, PDCD1, TLR5
8MP:000538510.2TLR5, PTPN22, FCGR2B, C3, PDCD1, C4B
9MP:001076810.0PTPN22, FCGR2B, STAT4, DNASE1, C3, PDCD1

Publications for Systemic Lupus Erythematosus

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Articles related to Systemic Lupus Erythematosus:

(show top 50)    (show all 4470)
idTitleAuthorsYear
1
Active systemic lupus erythematosus is associated with a reduced cytokine production by B cells in response to TLR9 stimulation. (25385499)
2014
2
T lymphocyte apoptosis in systemic lupus erythematosus patients. (24106599)
2013
3
Vitamin d deficiency and systemic lupus erythematosus: cause or consequence? (23904929)
2013
4
Association of RANTES and MBL gene polymorphisms with systemic lupus erythematosus: a meta-analysis. (23065234)
2013
5
Factors that determine body composition of female systemic lupus erythematosus (SLE) patients in Sri Lanka: a comparative study using dual-energy x-ray absorptiometry. (23861026)
2013
6
Diffuse dystrophic calcinosis cutis of the scalp in a patient with scalp discoid lupus erythematosus and systemic lupus erythematosus. (23426499)
2013
7
Neutrophil-Mediated IFN Activation in the Bone Marrow Alters B Cell Development in Human and Murine Systemic Lupus Erythematosus. (24379124)
2013
8
Irritable bowel syndrome-type symptoms in female patients with mild systemic lupus erythematosus: frequency, related factors and quality of life. (24112121)
2013
9
Rituximab-induced serum sickness in overlapping syndrome between sjAPgren syndrome and systemic lupus erythematosus. (23965477)
2013
10
Elevated norepinephrine may be an etiological factor in a wide range of diseases: age-related macular degeneration, systemic lupus erythematosus, atrial fibrillation, metabolic syndrome. (23410497)
2013
11
Lack of association between IL-23R gene polymorphisms and systemic lupus erythematosus in a Chinese population. (23754344)
2013
12
Serum levels of transforming growth factor-I^1 (TGF-I^1) in patients with systemic lupus erythematosus and Hashimoto's thyroiditis. (23614931)
2013
13
Polimorphisms in inflammasome genes are involved in the predisposition to systemic lupus erythematosus. (22235789)
2012
14
Splenic infarction, warm autoimmune hemolytic anemia and antiphospholipid antibodies associated with systemic lupus erythematosus. (22623174)
2012
15
Elevation of human tumor necrosis factor-like weak inducer of apoptosis in peripheral blood mononuclear cells is correlated with disease activity and lupus nephritis in patients with systemic lupus erythematosus. (21163672)
2011
16
Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus. (21068098)
2011
17
Extragonadal germ cell tumor presenting in a woman with systemic lupus erythematosus: a case report. (20338049)
2010
18
Systemic lupus erythematosus patients have increased number of circulating plasmacytoid dendritic cells, but decreased myeloid dendritic cells with deficient CD83 expression. (18625638)
2008
19
Longitudinal myelitis, aseptic meningitis, and conus medullaris infarction as presenting manifestations of pediatric systemic lupus erythematosus. (18413416)
2008
20
CD8+CD28-, suppressive T cells in systemic lupus erythematosus. (18625635)
2008
21
HLA-DRB1 alleles in juvenile-onset systemic lupus erythematosus: renal histologic class correlations. (17401504)
2007
22
Preliminary clinical measurement of the expression of B-cell activating factor in Chinese systemic lupus erythematosus patients. (17506477)
2007
23
Circulating proangiogenic molecules PIGF, SDF-1 and sVCAM-1 in patients with systemic lupus erythematosus. (17964973)
2007
24
Effect of dsDNA binding to SmD-derived peptides on clinical accuracy in the diagnosis of systemic lupus erythematosus. (17640359)
2007
25
CRP and the disposal of dying cells: consequences for systemic lupus erythematosus and rheumatoid arthritis. (17516213)
2007
26
Effect of prolactin on CD40/CD154 expression on peripheral blood mononuclear cells in patients with systemic lupus erythematosus]. (17884785)
2007
27
C-Reactive protein and its implications in systemic lupus erythematosus. (18159197)
2007
28
Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. (15657875)
2005
29
Peripheral neuropathy in pediatric systemic lupus erythematosus. (12770683)
2003
30
The A/T mutation in exon 2 of the DNASE1 gene is not present in Tunisian patients with systemic lupus erythematosus or in healthy subjects. (14613299)
2003
31
TAP1 and TAP2 polymorphisms analysis in northwestern Colombian patients with systemic lupus erythematosus. (12634240)
2003
32
Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus. (12145745)
2002
33
Coronary artery disease in systemic lupus erythematosus: A review of the literature. (11404827)
2001
34
Serum levels of angiogenic cytokines in systemic lupus erythematosus and their correlation with disease activity. (11566625)
2001
35
Hypercalcaemia in systemic lupus erythematosus. (11346230)
2001
36
Nocardiosis in patients with systemic lupus erythematosus. The Singapore Lupus Study Group. (10813308)
2000
37
Chronic intestinal pseudo-obstruction in systemic lupus erythematosus due to intestinal smooth muscle myopathy. (10981652)
2000
38
Cytotoxic T lymphocyte antigen 4 (CTLA-4) dimorphism in patients with systemic lupus erythematosus. (10609073)
1999
39
Systemic lupus erythematosus-associated catastrophic antiphospholipid syndrome occurring after typhoid fever: a possible role of Salmonella lipopolysaccharide in the occurrence of diffuse vasculopathy-coagulopathy. (10323464)
1999
40
Reduced purine 5'-nucleotidase activity in lymphocytes of patients with systemic lupus erythematosus: results of a pilot study. (10343529)
1999
41
Echocardiography in systemic lupus erythematosus. (9863896)
1998
42
Anti-A2/RA33 autoantibodies are directed to the RNA binding region of the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. Differential epitope recognition in rheumatoid arthritis, systemic lupus erythematosus, and mixed connective tissue disease. (9202064)
1997
43
Human parvovirus infection: rheumatic manifestations, angioedema, C1 esterase inhibitor deficiency, ANA positivity, and possible onset of systemic lupus erythematosus. (8823689)
1996
44
Elevated soluble CD27 levels in serum of patients with systemic lupus erythematosus. (8938100)
1996
45
Population and family studies of three disease-related polymorphic genes in systemic lupus erythematosus. (7706484)
1995
46
Distinguishing beta 2-glycoprotein I dependent (systemic lupus erythematosus type) and independent (syphilis type) anticardiolipin antibody with Tween 20. (7918046)
1993
47
Activation markers on peripheral blood T cells from patients with active or inactive systemic lupus erythematosus. Correlation with proliferative responses and production of IL-2. (1812897)
1991
48
Systemic lupus erythematosus and miliary tuberculosis in a prepubertal girl--a case report. (2152059)
1990
49
Possible association between anti-Ro antibodies and myocarditis or cardiac conduction defects in adults with systemic lupus erythematosus. (2396870)
1990
50
Studies of peritoneal macrophage function in murine systemic lupus erythematosus. 2. Nature of elevated resident peritoneal cells in NZB and (NZB x NZW)F1 mice. (3861745)
1985

Variations for Systemic Lupus Erythematosus

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UniProtKB/Swiss-Prot genetic disease variations for Systemic Lupus Erythematosus:

63
id Symbol AA change Variation ID SNP ID
1TREX1p.Arg169HisVAR_028319
2TREX1p.Ala213ValVAR_037949
3TREX1p.Gly282SerVAR_037950rs113107733
4TREX1p.Arg295SerVAR_037951rs72556555
5TREX1p.Ala302ProVAR_037952rs112741962
6TREX1p.Pro345LeuVAR_037954
7TREX1p.Tyr360CysVAR_037955
8TREX1p.Gly361AlaVAR_037956
9TREX1p.Asp255HisVAR_070901

Expression for genes affiliated with Systemic Lupus Erythematosus

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets, 31LifeMap Discovery®
See all sources
LifeMap Discovery
Genes differentially expressed in tissues of Systemic Lupus Erythematosus patients vs. healthy controls: 31 (show all 234)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1IFI27interferon, alpha-inducible protein 27Blood+5.470.000
2OTOFotoferlinBlood+5.250.000
3RPS4Y1ribosomal protein S4, Y-linked 1Blood-4.400.000
4IFIT1interferon-induced protein with tetratricopeptide repeats 1Blood+4.220.000
5LINC00661long intergenic non-protein coding RNA 661Blood+4.150.000
6SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesinBlood+4.120.000
7EIF1AYeukaryotic translation initiation factor 1A, Y-linkedBlood-3.960.000
8RSAD2radical S-adenosyl methionine domain containing 2Blood+3.810.000
9IFI44Linterferon-induced protein 44-likeBlood+3.580.000
10USP41ubiquitin specific peptidase 41Blood+3.400.000
11HESX1HESX homeobox 1Blood+3.220.000
12IFIT3interferon-induced protein with tetratricopeptide repeats 3Blood+3.080.000
13IFI44interferon-induced protein 44Blood+2.770.000
14ISG15ISG15 ubiquitin-like modifierBlood+2.770.000
15LY6Elymphocyte antigen 6 complex, locus EBlood+2.700.000
16OAS22'-5'-oligoadenylate synthetase 2, 69/71kDaBlood+2.640.000
17OAS32'-5'-oligoadenylate synthetase 3, 100kDaBlood+2.620.000
18OAS12'-5'-oligoadenylate synthetase 1, 40/46kDaBlood+2.610.000
19SPATS2Lspermatogenesis associated, serine-rich 2-likeBlood+2.600.000
20USP18ubiquitin specific peptidase 18Blood+2.590.000
21OASL2'-5'-oligoadenylate synthetase-likeBlood+2.480.000
22IFITM3interferon induced transmembrane protein 3Blood+2.420.000
23TRIM6tripartite motif containing 6Blood+2.350.000
24HERC5HECT and RLD domain containing E3 ubiquitin protein ligase 5Blood+2.320.000
25SERPING1serpin peptidase inhibitor, clade G (C1 inhibitor), member 1Blood+2.280.000
26PMLpromyelocytic leukemiaBlood+2.270.000
27LTFlactotransferrinBlood+2.260.000
28EPSTI1epithelial stromal interaction 1 (breast)Blood+2.230.000
29PRKYprotein kinase, Y-linked, pseudogeneBlood-2.180.000
30NAIPNLR family, apoptosis inhibitory proteinBlood+2.170.000
31MX1myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)Blood+2.120.000
32NBPF12neuroblastoma breakpoint family, member 12Blood+2.110.000
33KDM5Dlysine (K)-specific demethylase 5DBlood-2.100.001
34TXLNG2Ptaxilin gamma 2, pseudogeneBlood-2.080.001
35ZBP1Z-DNA binding protein 1Blood+2.080.000
36KIR2DL1killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1Blood-2.070.000
37XAF1XIAP associated factor 1Blood+2.060.000
38SLC26A8solute carrier family 26 (anion exchanger), member 8Blood+2.030.000
39MAP2K6mitogen-activated protein kinase kinase 6Blood+2.030.000
40RNF213ring finger protein 213Blood+2.000.000
41LINC01181long intergenic non-protein coding RNA 1181Blood+1.980.000
42TSHZ2teashirt zinc finger homeobox 2Blood-1.980.000
43FCARFc fragment of IgA, receptor forBlood+1.980.000
44IGFL2IGF-like family member 2Blood+1.970.000
45RTP4receptor (chemosensory) transporter protein 4Blood+1.970.000
46LAMP3lysosomal-associated membrane protein 3Blood+1.950.000
47BATF2basic leucine zipper transcription factor, ATF-like 2Blood+1.940.000
48LARGElike-glycosyltransferaseBlood-1.930.000
49PDZK1IP1PDZK1 interacting protein 1Blood-1.920.000
50CCL2chemokine (C-C motif) ligand 2Blood+1.910.000
51EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 2Blood+1.900.000
52CXCL11chemokine (C-X-C motif) ligand 11Blood+1.890.000
53TMSB4Ythymosin beta 4, Y-linkedBlood-1.890.003
54IL1RNinterleukin 1 receptor antagonistBlood+1.870.000
55SRGAP2SLIT-ROBO Rho GTPase activating protein 2Blood+1.860.000
56APOL6apolipoprotein L, 6Blood+1.830.000
57UTYubiquitously transcribed tetratricopeptide repeat containing, Y-linkedBlood-1.830.004
58HES4hes family bHLH transcription factor 4Blood+1.830.000
59LGALS3BPlectin, galactoside-binding, soluble, 3 binding proteinBlood+1.830.000
60KCNG1potassium voltage-gated channel, subfamily G, member 1Blood-1.820.000
61CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)Blood+1.810.001
62TRIM14tripartite motif containing 14Blood+1.810.000
63RPL3Lribosomal protein L3-likeBlood-1.800.002
64LOC400499uncharacterized LOC400499Blood+1.800.000
65SIGLEC17Psialic acid binding Ig-like lectin 17, pseudogeneBlood-1.800.000
66C14orf132chromosome 14 open reading frame 132Blood-1.780.000
67GPD2glycerol-3-phosphate dehydrogenase 2 (mitochondrial)Blood+1.780.000
68TXNDC5thioredoxin domain containing 5 (endoplasmic reticulum)Blood+1.760.000
69CASP8caspase 8, apoptosis-related cysteine peptidaseBlood+1.750.000
70NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zetaBlood+1.740.000
71LINC00668long intergenic non-protein coding RNA 668Blood+1.720.000
72HERC6HECT and RLD domain containing E3 ubiquitin protein ligase family member 6Blood+1.720.000
73FAM225Afamily with sequence similarity 225, member A (non-protein coding)Blood+1.710.000
74FOXO3forkhead box O3Blood+1.710.000
75PLSCR1phospholipid scramblase 1Blood+1.710.000
76CD274CD274 moleculeBlood+1.700.000
77LINC00342long intergenic non-protein coding RNA 342Blood+1.700.000
78CNN3calponin 3, acidicBlood-1.690.000
79TNFAIP6tumor necrosis factor, alpha-induced protein 6Blood+1.680.000
80DISC1disrupted in schizophrenia 1Blood+1.670.000
81RPS26P10ribosomal protein S26 pseudogene 10Blood-1.660.006
82CNTNAP2contactin associated protein-like 2Blood-1.650.011
83DSC1desmocollin 1Blood-1.650.000
84CD3DCD3d molecule, delta (CD3-TCR complex)Blood-1.640.000
85ABCA13ATP-binding cassette, sub-family A (ABC1), member 13Blood+1.640.002
86HIST2H2BFhistone cluster 2, H2bfBlood+1.640.000
87FEZ1fasciculation and elongation protein zeta 1 (zygin I)Blood-1.640.000
88UG0898H09uncharacterized LOC643763Blood+1.630.000
89DBNDD1dysbindin (dystrobrevin binding protein 1) domain containing 1Blood-1.620.000
90IFIH1interferon induced with helicase C domain 1Blood+1.620.000
91SAMD9Lsterile alpha motif domain containing 9-likeBlood+1.610.000
92ATP6V0E2-AS1ATP6V0E2 antisense RNA 1Blood+1.610.007
93HELZ2helicase with zinc finger 2, transcriptional coactivatorBlood+1.610.000
94COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)Blood-1.600.000
95MLKLmixed lineage kinase domain-likeBlood+1.600.000
96DHX58DEXH (Asp-Glu-X-His) box polypeptide 58Blood+1.590.000
97PTGDSprostaglandin D2 synthase 21kDa (brain)Blood-1.590.001
98SIGLEC5sialic acid binding Ig-like lectin 5Blood+1.590.000
99PDLIM5PDZ and LIM domain 5Blood+1.580.000
100RASSF2Ras association (RalGDS/AF-6) domain family member 2Blood+1.580.000
101IFIT2interferon-induced protein with tetratricopeptide repeats 2Blood+1.580.000
102TSC22D3TSC22 domain family, member 3Blood+1.580.000
103NTSR1neurotensin receptor 1 (high affinity)Blood+1.570.004
104CD1CCD1c moleculeBlood-1.570.001
105PRSS23protease, serine, 23Blood-1.570.001
106LIMK2LIM domain kinase 2Blood+1.570.000
107FAM13Afamily with sequence similarity 13, member ABlood+1.570.000
108IRF7interferon regulatory factor 7Blood+1.560.000
109KIAA1958KIAA1958Blood+1.550.000
110KLRC3killer cell lectin-like receptor subfamily C, member 3Blood-1.550.000
111GBP6guanylate binding protein family, member 6Blood+1.550.001
112C15orf48chromosome 15 open reading frame 48Blood+1.550.001
113LOC390933protein associated with topoisomerase II homolog 1 (yeast) pseudogeneBlood+1.550.000
114LINC00937long intergenic non-protein coding RNA 937Blood+1.540.002
115C1QCcomplement component 1, q subcomponent, C chainBlood+1.540.002
116USP9Yubiquitin specific peptidase 9, Y-linkedBlood-1.540.020
117CCNA1cyclin A1Blood+1.530.003
118LOC729732uncharacterized LOC729732Blood+1.530.001
119IL4interleukin 4Blood-1.530.001
120NTNG2netrin G2Blood+1.530.000
121CAMK2N1calcium/calmodulin-dependent protein kinase II inhibitor 1Blood-1.520.001
122CACNA2D2calcium channel, voltage-dependent, alpha 2/delta subunit 2Blood-1.510.000
123ANKRD22ankyrin repeat domain 22Blood+1.510.001
124PID1phosphotyrosine interaction domain containing 1Blood-1.500.002
125SLC1A3solute carrier family 1 (glial high affinity glutamate transporter), member 3Blood+1.500.000
126KRT72keratin 72Blood-1.500.032
127DGKZdiacylglycerol kinase, zetaBlood+1.490.001
128ARHGAP25Rho GTPase activating protein 25Blood+1.490.000
129NRCAMneuronal cell adhesion moleculeBlood-1.490.015
130IFIT5interferon-induced protein with tetratricopeptide repeats 5Blood+1.490.000
131BCL6B-cell CLL/lymphoma 6Blood+1.480.002
132TTTY15testis-specific transcript, Y-linked 15 (non-protein coding)Blood-1.480.042
133APOBEC3Bapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3BBlood+1.470.014
134PPP2R5Dprotein phosphatase 2, regulatory subunit B', deltaBlood+1.470.002
135NAP1L3nucleosome assembly protein 1-like 3Blood-1.470.000
136CCL8chemokine (C-C motif) ligand 8Blood+1.470.001
137C1orf186chromosome 1 open reading frame 186Blood-1.460.006
138LINC00982long intergenic non-protein coding RNA 982Blood-1.460.000
139CUX1cut-like homeobox 1Blood+1.450.002
140UNC93B1unc-93 homolog B1 (C. elegans)Blood+1.450.000
141TMEM30Btransmembrane protein 30BBlood-1.450.001
142FSD1Lfibronectin type III and SPRY domain containing 1-likeBlood+1.440.005
143MIR205HGMIR205 host gene (non-protein coding)Blood+1.440.002
144DNAAF1dynein, axonemal, assembly factor 1Blood+1.440.004
145DEFB1defensin, beta 1Blood+1.430.007
146GPR84G protein-coupled receptor 84Blood+1.430.002
147APOBEC3Aapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3ABlood+1.430.018
148DOC2Adouble C2-like domains, alphaBlood-1.420.005
149SELMselenoprotein MBlood-1.420.001
150MMP8matrix metallopeptidase 8 (neutrophil collagenase)Blood+1.420.035
151RTN3reticulon 3Blood+1.420.014
152IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)Blood+1.420.004
153PMEPA1prostate transmembrane protein, androgen induced 1Blood-1.420.027
154ELANEelastase, neutrophil expressedBlood+1.410.030
155ABCB4ATP-binding cassette, sub-family B (MDR/TAP), member 4Blood-1.410.025
156CXCL10chemokine (C-X-C motif) ligand 10Blood+1.410.003
157MCM7minichromosome maintenance complex component 7Blood+1.400.015
158ALDH3B1aldehyde dehydrogenase 3 family, member B1Blood+1.400.006
159CEACAM1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)Blood+1.400.000
160GAB2GRB2-associated binding protein 2Blood+1.400.000
161SOCS1suppressor of cytokine signaling 1Blood+1.400.002
162KLRB1killer cell lectin-like receptor subfamily B, member 1Blood-1.390.000
163FGF9fibroblast growth factor 9Blood-1.390.008
164EPHX4epoxide hydrolase 4Blood-1.380.003
165C1orf21chromosome 1 open reading frame 21Blood-1.380.017
166CD22CD22 moleculeBlood-1.380.027
167IGFBP3insulin-like growth factor binding protein 3Blood-1.370.015
168SLC1A7solute carrier family 1 (glutamate transporter), member 7Blood-1.360.014
169FCGBPFc fragment of IgG binding proteinBlood-1.360.032
170NBPF14neuroblastoma breakpoint family, member 14Blood+1.350.002
171NXNL1nucleoredoxin-like 1Blood+1.350.031
172ELOVL4ELOVL fatty acid elongase 4Blood-1.340.007
173NLRP12NLR family, pyrin domain containing 12Blood+1.340.009
174CACNA1Ecalcium channel, voltage-dependent, R type, alpha 1E subunitBlood+1.340.043
175KRT73keratin 73Blood-1.340.026
176SP3Sp3 transcription factorBlood+1.340.022
177FCER1AFc fragment of IgE, high affinity I, receptor for; alpha polypeptideBlood-1.340.012
178PDZD4PDZ domain containing 4Blood-1.340.006
179TRIM22tripartite motif containing 22Blood+1.340.000
180SALL2spalt-like transcription factor 2Blood-1.340.043
181EEF1B2eukaryotic translation elongation factor 1 beta 2Blood-1.330.000
182WSB1WD repeat and SOCS box containing 1Blood+1.330.000
183GATMglycine amidinotransferase (L-arginine:glycine amidinotransferase)Blood-1.330.023
184SORBS3sorbin and SH3 domain containing 3Blood-1.330.027
185PARP9poly (ADP-ribose) polymerase family, member 9Blood+1.330.000
186PNPT1polyribonucleotide nucleotidyltransferase 1Blood+1.330.000
187LOC390876ribosomal protein L35 pseudogeneBlood-1.320.041
188SPINK2serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)Blood-1.320.023
189KCTD14potassium channel tetramerization domain containing 14Blood+1.320.038
190TRIM78Ptripartite motif containing 78, pseudogeneBlood+1.320.001
191RPL14ribosomal protein L14Blood-1.320.004
192APOL1apolipoprotein L, 1Blood+1.310.019
193GBP1guanylate binding protein 1, interferon-inducibleBlood+1.310.004
194BTN3A1butyrophilin, subfamily 3, member A1Blood+1.310.013
195GNB4guanine nucleotide binding protein (G protein), beta polypeptide 4Blood+1.310.002
196TRIM5tripartite motif containing 5Blood+1.300.001
197FAPfibroblast activation protein, alphaBlood+1.300.010
198PARP12poly (ADP-ribose) polymerase family, member 12Blood+1.300.004
199LOC554223histocompatibility antigen-relatedBlood+1.300.033
200SLC16A11solute carrier family 16, member 11Blood-1.300.043
201DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 58Blood+1.290.003
202WDFY3WD repeat and FYVE domain containing 3Blood+1.290.011
203AKIRIN1akirin 1Blood+1.290.018
204TLR2toll-like receptor 2Blood+1.280.002
205ARSDarylsulfatase DBlood+1.280.012
206CAMTA1calmodulin binding transcription activator 1Blood-1.280.039
207MGC40069uncharacterized protein MGC40069Blood-1.270.040
208SGCEsarcoglycan, epsilonBlood-1.270.047
209PTGFRprostaglandin F receptor (FP)Blood+1.270.046
210ZNF365zinc finger protein 365Blood-1.270.038
211UBE2L6ubiquitin-conjugating enzyme E2L 6Blood+1.270.001
212KIAA0319LKIAA0319-likeBlood+1.270.002
213STAT1signal transducer and activator of transcription 1, 91kDaBlood+1.270.002
214DKK3dickkopf WNT signaling pathway inhibitor 3Blood-1.260.036
215IFI35interferon-induced protein 35Blood+1.260.008
216ZNF684zinc finger protein 684Blood+1.250.007
217LAP3leucine aminopeptidase 3Blood+1.250.013
218HIST1H4Dhistone cluster 1, H4dBlood+1.250.033
219FAM19A1family with sequence similarity 19 (chemokine (C-C motif)-like), member A1Blood-1.250.039
220USP4ubiquitin specific peptidase 4 (proto-oncogene)Blood+1.240.006
221NOMO3NODAL modulator 3Blood+1.230.036
222ABCB1ATP-binding cassette, sub-family B (MDR/TAP), member 1Blood-1.220.021
223BACH1BTB and CNC homology 1, basic leucine zipper transcription factor 1Blood+1.220.016
224LGR6leucine-rich repeat containing G protein-coupled receptor 6Blood-1.220.046
225MT2Ametallothionein 2ABlood+1.220.028
226SAMD9sterile alpha motif domain containing 9Blood+1.210.020
227MT1Gmetallothionein 1GBlood+1.210.041
228CREB5cAMP responsive element binding protein 5Blood+1.200.048
229BTN2A1butyrophilin, subfamily 2, member A1Blood+1.200.028
230PFN2profilin 2Blood-1.190.030
231GPR141G protein-coupled receptor 141Blood+1.180.047
232CDC42EP3CDC42 effector protein (Rho GTPase binding) 3Blood+1.180.032
233GALMgalactose mutarotase (aldose 1-epimerase)Blood+1.170.035
234TXNDC12thioredoxin domain containing 12 (endoplasmic reticulum)Blood-1.160.027

Expression patterns in normal tissues for genes affiliated with Systemic Lupus Erythematosus

Search GEO for disease gene expression data for Systemic Lupus Erythematosus.

Pathways for genes affiliated with Systemic Lupus Erythematosus

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Pathways related to Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.4TLR5, STAT4, C3
2
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
10.4C3, STAT4, TLR5
310.4BANK1, CR2, FCGR2B
4
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
10.4CR2, PDCD1, FCGR2B
5
Show member pathways
10.4TLR5, FCGR2B, STAT4, CR2
610.4C4B, C4A, C3
710.4FCGR2B, C3, C4A, C4B
8
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
10.4C3, CR2, C4A, C4B
9
Show member pathways
Immune response Alternative complement pathway59
Immune response Lectin Induced complement pathway59
Immune response Classic complement pathway59
10.4C4B, C4A, CR2, C3

Compounds for genes affiliated with Systemic Lupus Erythematosus

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Sources:
44Novoseek
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Compounds related to Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1agarose4410.5C4B, C4A, C3, DNASE1
2anaphylatoxin4410.4C4A, C3
3serine4410.4FCGR2B, STAT4, DNASE1, C3, CR2, C4A
4phosphatidylinositol4410.4TLR5, FCGR2B, STAT4, C3, CR2
5aurintricarboxylic acid4410.3DNASE1L3, DNASE1
6tyrosine4410.1TLR5, PTPN22, FCGR2B, STAT4, PDCD1, CR2

GO Terms for genes affiliated with Systemic Lupus Erythematosus

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Cellular components related to Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:07256210.4C4B, C4A, C3

Biological processes related to Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1complement activation, classical pathwayGO:00695810.5C4B, C4A, CR2, C3
2regulation of complement activationGO:03044910.5C3, C4A, C4B
3DNA metabolic processGO:00625910.4TREX1, DNASE1L3
4innate immune responseGO:04508710.3TLR5, C3, CR2, C4A, C4B, TREX1
5complement activationGO:00695610.3C4B, C4A, C3
6inflammatory responseGO:00695410.1TLR5, C3, C4A, C4B

Molecular functions related to Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:00486610.4C4B, C4A, C3

Products for genes affiliated with Systemic Lupus Erythematosus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Systemic Lupus Erythematosus

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet