MCID: SYS001
MIFTS: 92

Systemic Lupus Erythematosus malady

Genetic diseases, Rare diseases, Skin diseases, Bone diseases categories

Summaries for Systemic Lupus Erythematosus

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OMIM:47 Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies... (152700) more...

MalaCards based summary: Systemic Lupus Erythematosus, also known as disseminated lupus erythematosus, is related to lupus erythematosus and arthritis, and has symptoms including autosomal dominant inheritance, nephritis and psychosis. An important gene associated with Systemic Lupus Erythematosus is PTPN22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)), and among its related pathways are B Cell Receptor Signaling Pathway and CD28 co-stimulation. The drugs dehydroepiandrosterone and triamcinolone and the compounds agarose and serine have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and b cells, and related mouse phenotypes are hematopoietic system and renal/urinary system.

Disease Ontology:10 A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart.

CDC:4 Systemic Lupus Erythematosus is an autoimmune disease in which the immune system produces antibodies to cells within the body leading to widespread inflammation and tissue damage. The causes of SLE are unknown but are believed to be linked to genetic, environmental, and hormonal factors. SLE may be characterized by periods of illness and remissions. SLE has a variety of clinical manifestations and can affect joints, skin, brain, lungs, kidneys, and blood vessels. People with SLE may experience fatigue, pain or swelling in joints, skin rashes, and fevers. A team approach in treating lupus is often warranted due to the number of organ systems involved.

NINDS:44 Lupus (also called ) is a disorder of the immune system. Normally, the immune system protects the body against invading infections and cancers. In lupus, the immune system is over-active and produces increased amounts of abnormal antibodies that attack the body's tissues and organs. Lupus can affect many parts of the body, including the joints, skin, kidneys, lungs, heart, nervous system, and blood vessels. The signs and symptoms of lupus differ from person to person; the disease can range from mild to life threatening.

Genetics Home Reference:23 Systemic lupus erythematosus (SLE) is a chronic disease that causes inflammation in connective tissues, such as cartilage and the lining of blood vessels, which provide strength and flexibility to structures throughout the body. The signs and symptoms of SLE vary among affected individuals, and can involve many organs and systems, including the skin, joints, kidneys, lungs, central nervous system, and blood-forming (hematopoietic) system. SLE is one of a large group of conditions called autoimmune disorders that occur when the immune system attacks the body's own tissues and organs.

Wikipedia:65 Systemic lupus erythematosus i/s??st?m?k ?lu?p?s ??r??i?m??to?s?s/, often abbreviated as SLE or lupus,... more...

Aliases & Classifications for Systemic Lupus Erythematosus

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Systemic Lupus Erythematosus, Aliases & Descriptions:

Name: Systemic Lupus Erythematosus 47 32 10 23 44 12 4
Disseminated Lupus Erythematosus 10 23 62
Lupus Erythematosus, Systemic 10 62
Lupus Erythematosus Systemic 45 24
Libman-Sacks Disease 23 62
Le Syndrome 23 62
Lupus 23 62
 
Systemic Lupus Erythematosus, Susceptibility to or Protection Against 11
Systemic Lupus Erythematosus or Protection Against} 47
Systemic Lupus Erythematosus, Association with 47
Sle - Lupus Erythematosus, Systemic 10
Sle Nos 62
Sle 23


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Skin diseases, Bone diseases


External Ids:

OMIM47 152700
Disease Ontology10 DOID:9074
NCIt40 C3201
ICD9CM29 710.0
MeSH35 D008180
ICD1027 M32, M32.1

Related Diseases for Systemic Lupus Erythematosus

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Diseases in the Lupus Erythematosus family:

systemic lupus erythematosus Systemic Lupus Erythematosus 9
Systemic Lupus Erythematosus 1 Systemic Lupus Erythematosus 2
Systemic Lupus Erythematosus 16 Systemic Lupus Erythematosus 10
Dnase1-Related Susceptibility to Systemic Lupus Erythematosus Cr2-Related Susceptibility to Systemic Lupus Erythematosus
Autosomal Recessive Systemic Lupus Erythematosus

Diseases related to Systemic Lupus Erythematosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 900)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus33.0C3, TREX1, C4A, FCGR2B, DNASE1
2arthritis32.0PTPN22, C3, CTLA4, FCGR2B
3rheumatoid arthritis31.9PTPN22, CTLA4, PDCD1, C3, STAT4, FCGR2B
4connective tissue disease31.5FCGR2B, C3, TREX1, DNASE1, CTLA4, PTPN22
5thyroiditis31.3CTLA4, PTPN22
6complement deficiency31.0C3, C4A
7inflammatory bowel disease30.3PTPN22, STAT4, TLR5, CTLA4
8addison's disease30.3CTLA4, PTPN22
9ulcerative colitis30.2CTLA4, STAT4, TLR5
10pediatric systemic lupus erythematosus11.1
11antiphospholipid syndrome11.1
12nephritis11.1
13myelitis11.0
14endotheliitis11.0
15vasculitis11.0
16lupus nephritis11.0
17atherosclerosis10.9
18protein-losing enteropathy10.9
19transverse myelitis10.9
20mixed connective tissue disease10.9
21purpura10.9
22cerebritis10.9
23glomerulonephritis10.9
24retinitis10.9
25scleroderma10.9
26hepatitis10.8
27lymphopenia10.8
28discoid lupus erythematosus10.8
29thrombotic thrombocytopenic purpura10.8
30thrombocytopenia10.8
31klinefelter's syndrome10.8
32pure red-cell aplasia10.8
33diffuse alveolar hemorrhage10.8
34intestinal pseudo-obstruction10.7
35dermatomyositis10.7
36c1q deficiency10.7
37meningitis10.7
38aneurysm10.7
39cardiac tamponade10.7
40cutaneous lupus erythematosus10.7
41tuberculosis10.7
42myocardial infarction10.7
43congenital heart block10.7
44arthropathy10.7
45nervous system disease10.7
46pneumonia10.7
47vascular disease10.7
48rheumatic disease10.7
49juvenile rheumatoid arthritis10.7
50central nervous system disease10.7

Graphical network of the top 20 diseases related to Systemic Lupus Erythematosus:



Diseases related to systemic lupus erythematosus

Symptoms for Systemic Lupus Erythematosus

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Symptoms by clinical synopsis from OMIM:

152700

Clinical features from OMIM:

152700

HPO human phenotypes related to Systemic Lupus Erythematosus:

(show all 14)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 nephritis HP:0000123
3 psychosis HP:0000709
4 cutaneous photosensitivity HP:0000992
5 seizures HP:0001250
6 arthritis HP:0001369
7 pericarditis HP:0001701
8 thrombocytopenia HP:0001873
9 hemolytic anemia HP:0001878
10 leukopenia HP:0001882
11 pleuritis HP:0002102
12 systemic lupus erythematosus HP:0002725
13 antinuclear antibody positivity HP:0003493
14 antiphospholipid antibody positivity HP:0003613

Drugs & Therapeutics for Systemic Lupus Erythematosus

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Drug clinical trials:

Search ClinicalTrials for Systemic Lupus Erythematosus

Search NIH Clinical Center for Systemic Lupus Erythematosus

Inferred drug relations via UMLS62/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Systemic Lupus Erythematosus cell therapies at LifeMap Discovery.

Genetic Tests for Systemic Lupus Erythematosus

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Genetic tests related to Systemic Lupus Erythematosus:

id Genetic test Affiliating Genes
1 Systemic Lupus Erythematosus24

Anatomical Context for Systemic Lupus Erythematosus

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MalaCards organs/tissues related to Systemic Lupus Erythematosus:

33
T cells, Skin, B cells, Kidney, Lung, Heart, Endothelial, Neutrophil, Brain, Monocytes, Bone, Thyroid, Liver, Breast, Bone marrow, Testes, Pituitary, Prostate, Testis, Myeloid, Whole blood, Spleen, Nk cells, Eye, Spinal cord, Colon, Placenta, Skeletal muscle, Salivary gland, Uterus, Temporal lobe, Pineal, Smooth muscle

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Systemic Lupus Erythematosus:
id TissueAnatomical CompartmentCell Relevance
1 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Systemic Lupus Erythematosus or affiliated genes

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MGI Mouse Phenotypes related to Systemic Lupus Erythematosus:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.5TREX1, TLR5, PTPN22, FCGR2B, STAT4, DNASE1
2MP:000536710.5PTPN22, FCGR2B, STAT4, DNASE1, C3, PDCD1
3MP:000538710.5DNASE1, STAT4, FCGR2B, PTPN22, TLR5, C3
4MP:000537010.5TLR5, PTPN22, FCGR2B, C3, PDCD1, CTLA4
5MP:000538110.5TLR5, PTPN22, FCGR2B, C3, CTLA4, C4B
6MP:000537610.4TLR5, PTPN22, FCGR2B, STAT4, DNASE1, C3
7MP:001076810.3FCGR2B, STAT4, DNASE1, C3, PDCD1, CR2
8MP:000538510.3TLR5, PTPN22, FCGR2B, C3, PDCD1, CTLA4
9MP:000537910.1TLR5, PTPN22, FCGR2B, STAT4, C3, PDCD1

Publications for Systemic Lupus Erythematosus

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Articles related to Systemic Lupus Erythematosus:

(show top 50)    (show all 4526)
idTitleAuthorsYear
1
Active systemic lupus erythematosus is associated with a reduced cytokine production by B cells in response to TLR9 stimulation. (25385499)
2014
2
T lymphocyte apoptosis in systemic lupus erythematosus patients. (24106599)
2013
3
Vitamin d deficiency and systemic lupus erythematosus: cause or consequence? (23904929)
2013
4
Association of RANTES and MBL gene polymorphisms with systemic lupus erythematosus: a meta-analysis. (23065234)
2013
5
Factors that determine body composition of female systemic lupus erythematosus (SLE) patients in Sri Lanka: a comparative study using dual-energy x-ray absorptiometry. (23861026)
2013
6
Diffuse dystrophic calcinosis cutis of the scalp in a patient with scalp discoid lupus erythematosus and systemic lupus erythematosus. (23426499)
2013
7
Neutrophil-Mediated IFN Activation in the Bone Marrow Alters B Cell Development in Human and Murine Systemic Lupus Erythematosus. (24379124)
2013
8
Irritable bowel syndrome-type symptoms in female patients with mild systemic lupus erythematosus: frequency, related factors and quality of life. (24112121)
2013
9
Rituximab-induced serum sickness in overlapping syndrome between sjAPgren syndrome and systemic lupus erythematosus. (23965477)
2013
10
Elevated norepinephrine may be an etiological factor in a wide range of diseases: age-related macular degeneration, systemic lupus erythematosus, atrial fibrillation, metabolic syndrome. (23410497)
2013
11
Lack of association between IL-23R gene polymorphisms and systemic lupus erythematosus in a Chinese population. (23754344)
2013
12
Serum levels of transforming growth factor-I^1 (TGF-I^1) in patients with systemic lupus erythematosus and Hashimoto's thyroiditis. (23614931)
2013
13
Polimorphisms in inflammasome genes are involved in the predisposition to systemic lupus erythematosus. (22235789)
2012
14
Splenic infarction, warm autoimmune hemolytic anemia and antiphospholipid antibodies associated with systemic lupus erythematosus. (22623174)
2012
15
Elevation of human tumor necrosis factor-like weak inducer of apoptosis in peripheral blood mononuclear cells is correlated with disease activity and lupus nephritis in patients with systemic lupus erythematosus. (21163672)
2011
16
Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus. (21068098)
2011
17
Extragonadal germ cell tumor presenting in a woman with systemic lupus erythematosus: a case report. (20338049)
2010
18
Systemic lupus erythematosus patients have increased number of circulating plasmacytoid dendritic cells, but decreased myeloid dendritic cells with deficient CD83 expression. (18625638)
2008
19
Longitudinal myelitis, aseptic meningitis, and conus medullaris infarction as presenting manifestations of pediatric systemic lupus erythematosus. (18413416)
2008
20
HLA-DRB1 alleles in juvenile-onset systemic lupus erythematosus: renal histologic class correlations. (17401504)
2007
21
Preliminary clinical measurement of the expression of B-cell activating factor in Chinese systemic lupus erythematosus patients. (17506477)
2007
22
Circulating proangiogenic molecules PIGF, SDF-1 and sVCAM-1 in patients with systemic lupus erythematosus. (17964973)
2007
23
Effect of dsDNA binding to SmD-derived peptides on clinical accuracy in the diagnosis of systemic lupus erythematosus. (17640359)
2007
24
CRP and the disposal of dying cells: consequences for systemic lupus erythematosus and rheumatoid arthritis. (17516213)
2007
25
Effect of prolactin on CD40/CD154 expression on peripheral blood mononuclear cells in patients with systemic lupus erythematosus]. (17884785)
2007
26
C-Reactive protein and its implications in systemic lupus erythematosus. (18159197)
2007
27
Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. (15657875)
2005
28
Peripheral neuropathy in pediatric systemic lupus erythematosus. (12770683)
2003
29
The A/T mutation in exon 2 of the DNASE1 gene is not present in Tunisian patients with systemic lupus erythematosus or in healthy subjects. (14613299)
2003
30
TAP1 and TAP2 polymorphisms analysis in northwestern Colombian patients with systemic lupus erythematosus. (12634240)
2003
31
Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus. (12145745)
2002
32
Coronary artery disease in systemic lupus erythematosus: A review of the literature. (11404827)
2001
33
Serum levels of angiogenic cytokines in systemic lupus erythematosus and their correlation with disease activity. (11566625)
2001
34
Hypercalcaemia in systemic lupus erythematosus. (11346230)
2001
35
Nocardiosis in patients with systemic lupus erythematosus. The Singapore Lupus Study Group. (10813308)
2000
36
Chronic intestinal pseudo-obstruction in systemic lupus erythematosus due to intestinal smooth muscle myopathy. (10981652)
2000
37
Cytotoxic T lymphocyte antigen 4 (CTLA-4) dimorphism in patients with systemic lupus erythematosus. (10609073)
1999
38
Systemic lupus erythematosus-associated catastrophic antiphospholipid syndrome occurring after typhoid fever: a possible role of Salmonella lipopolysaccharide in the occurrence of diffuse vasculopathy-coagulopathy. (10323464)
1999
39
Reduced purine 5'-nucleotidase activity in lymphocytes of patients with systemic lupus erythematosus: results of a pilot study. (10343529)
1999
40
Echocardiography in systemic lupus erythematosus. (9863896)
1998
41
Anti-A2/RA33 autoantibodies are directed to the RNA binding region of the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. Differential epitope recognition in rheumatoid arthritis, systemic lupus erythematosus, and mixed connective tissue disease. (9202064)
1997
42
Human parvovirus infection: rheumatic manifestations, angioedema, C1 esterase inhibitor deficiency, ANA positivity, and possible onset of systemic lupus erythematosus. (8823689)
1996
43
Elevated soluble CD27 levels in serum of patients with systemic lupus erythematosus. (8938100)
1996
44
Population and family studies of three disease-related polymorphic genes in systemic lupus erythematosus. (7706484)
1995
45
Distinguishing beta 2-glycoprotein I dependent (systemic lupus erythematosus type) and independent (syphilis type) anticardiolipin antibody with Tween 20. (7918046)
1993
46
Activation markers on peripheral blood T cells from patients with active or inactive systemic lupus erythematosus. Correlation with proliferative responses and production of IL-2. (1812897)
1991
47
Systemic lupus erythematosus and miliary tuberculosis in a prepubertal girl--a case report. (2152059)
1990
48
Plasma lactoferrin and neutrophil elastase in rheumatoid arthritis and systemic lupus erythematosus. (2306568)
1990
49
Possible association between anti-Ro antibodies and myocarditis or cardiac conduction defects in adults with systemic lupus erythematosus. (2396870)
1990
50
Studies of peritoneal macrophage function in murine systemic lupus erythematosus. 2. Nature of elevated resident peritoneal cells in NZB and (NZB x NZW)F1 mice. (3861745)
1985

Variations for Systemic Lupus Erythematosus

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UniProtKB/Swiss-Prot genetic disease variations for Systemic Lupus Erythematosus:

64
id Symbol AA change Variation ID SNP ID
1PTPN22p.Arg620TrpVAR_022605rs2476601
2TREX1p.Arg169HisVAR_028319
3TREX1p.Ala213ValVAR_037949
4TREX1p.Gly282SerVAR_037950rs113107733
5TREX1p.Arg295SerVAR_037951rs72556555
6TREX1p.Ala302ProVAR_037952rs112741962
7TREX1p.Pro345LeuVAR_037954
8TREX1p.Tyr360CysVAR_037955
9TREX1p.Gly361AlaVAR_037956
10TREX1p.Asp255HisVAR_070901

Expression for genes affiliated with Systemic Lupus Erythematosus

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LifeMap Discovery
Genes differentially expressed in tissues of Systemic Lupus Erythematosus patients vs. healthy controls: 32 (show all 234)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1RPS4Y1ribosomal protein S4, Y-linked 1Blood-4.400.000
2EIF1AYeukaryotic translation initiation factor 1A, Y-linkedBlood-3.960.000
3PRTN3proteinase 3Blood+3.610.000
4AZU1azurocidin 1Blood+3.540.000
5MPOmyeloperoxidaseBlood+3.340.000
6ELANEelastase, neutrophil expressedBlood+3.310.000
7DEFA4defensin, alpha 4, corticostatinBlood+3.240.000
8GPER1G protein-coupled estrogen receptor 1Blood+3.070.000
9HPhaptoglobinBlood+2.990.000
10SLCO4A1solute carrier organic anion transporter family, member 4A1Blood+2.980.000
11C1QBcomplement component 1, q subcomponent, B chainBlood+2.960.000
12SLC1A3solute carrier family 1 (glial high affinity glutamate transporter), member 3Blood+2.890.000
13CENPMcentromere protein MBlood+2.890.000
14AMPHamphiphysinBlood+2.840.000
15CDT1chromatin licensing and DNA replication factor 1Blood+2.820.000
16MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)Blood+2.800.000
17KIF20Akinesin family member 20ABlood+2.790.000
18C1QAcomplement component 1, q subcomponent, A chainBlood+2.750.000
19TRIP13thyroid hormone receptor interactor 13Blood+2.740.000
20LRRN1leucine rich repeat neuronal 1Blood+2.730.000
21BPIbactericidal/permeability-increasing proteinBlood+2.700.000
22CTSGcathepsin GBlood+2.690.000
23DAAM2dishevelled associated activator of morphogenesis 2Blood+2.650.000
24CDC25Acell division cycle 25ABlood+2.650.000
25ATP6V0E2-AS1ATP6V0E2 antisense RNA 1Blood+2.650.000
26HTRA1HtrA serine peptidase 1Blood+2.640.000
27RAP1GAPRAP1 GTPase activating proteinBlood+2.630.000
28NT5DC25'-nucleotidase domain containing 2Blood+2.630.000
29APOBEC3Bapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3BBlood+2.600.000
30ZDHHC19zinc finger, DHHC-type containing 19Blood+2.560.000
31BUB1BBUB1 mitotic checkpoint serine/threonine kinase BBlood+2.540.000
32GAS2L1growth arrest-specific 2 like 1Blood+2.510.000
33C18orf56chromosome 18 open reading frame 56Blood+2.500.000
34CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)Blood+2.470.000
35TK1thymidine kinase 1, solubleBlood+2.470.000
36C1QCcomplement component 1, q subcomponent, C chainBlood+2.460.000
37GPR84G protein-coupled receptor 84Blood+2.460.000
38CEACAM8carcinoembryonic antigen-related cell adhesion molecule 8Blood+2.450.000
39UHRF1ubiquitin-like with PHD and ring finger domains 1Blood+2.450.000
40TYMSthymidylate synthetaseBlood+2.450.000
41OLAHoleoyl-ACP hydrolaseBlood+2.430.000
42ECHDC3enoyl CoA hydratase domain containing 3Blood+2.420.000
43AURKBaurora kinase BBlood+2.420.000
44FKBP5FK506 binding protein 5Blood+2.420.000
45CLEC11AC-type lectin domain family 11, member ABlood+2.410.000
46TCN2transcobalamin IIBlood+2.400.000
47SOCS1suppressor of cytokine signaling 1Blood+2.380.000
48GRB10growth factor receptor-bound protein 10Blood+2.380.000
49CEP55centrosomal protein 55kDaBlood+2.370.000
50FCARFc fragment of IgA, receptor forBlood+2.370.000
51ANKRD9ankyrin repeat domain 9Blood+2.360.000
52RETNresistinBlood+2.350.000
53CYB5R2cytochrome b5 reductase 2Blood+2.350.000
54KIF2Ckinesin family member 2CBlood+2.350.000
55ST14suppression of tumorigenicity 14 (colon carcinoma)Blood+2.340.000
56C19orf59chromosome 19 open reading frame 59Blood+2.330.000
57MCM10minichromosome maintenance complex component 10Blood+2.330.000
58ANKRD22ankyrin repeat domain 22Blood+2.320.000
59RXRGretinoid X receptor, gammaBlood+2.310.000
60LGALS3BPlectin, galactoside-binding, soluble, 3 binding proteinBlood+2.290.000
61PGLYRP1peptidoglycan recognition protein 1Blood+2.280.000
62FAM83Afamily with sequence similarity 83, member ABlood+2.270.000
63DLGAP5discs, large (Drosophila) homolog-associated protein 5Blood+2.260.000
64PRKYprotein kinase, Y-linked, pseudogeneBlood-2.180.000
65KDM5Dlysine (K)-specific demethylase 5DBlood-2.100.001
66TXLNG2Ptaxilin gamma 2, pseudogeneBlood-2.080.001
67KIR2DL1killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1Blood-2.070.000
68TSHZ2teashirt zinc finger homeobox 2Blood-1.980.000
69LARGElike-glycosyltransferaseBlood-1.930.000
70PDZK1IP1PDZK1 interacting protein 1Blood-1.920.000
71TMSB4Ythymosin beta 4, Y-linkedBlood-1.890.003
72UTYubiquitously transcribed tetratricopeptide repeat containing, Y-linkedBlood-1.830.004
73KCNG1potassium voltage-gated channel, subfamily G, member 1Blood-1.820.000
74RPL3Lribosomal protein L3-likeBlood-1.800.002
75SIGLEC17Psialic acid binding Ig-like lectin 17, pseudogeneBlood-1.800.000
76C14orf132chromosome 14 open reading frame 132Blood-1.780.000
77LINC00342long intergenic non-protein coding RNA 342Blood+1.700.000
78CNN3calponin 3, acidicBlood-1.690.000
79TNFAIP6tumor necrosis factor, alpha-induced protein 6Blood+1.680.000
80DISC1disrupted in schizophrenia 1Blood+1.670.000
81RPS26P10ribosomal protein S26 pseudogene 10Blood-1.660.006
82CNTNAP2contactin associated protein-like 2Blood-1.650.011
83DSC1desmocollin 1Blood-1.650.000
84CD3DCD3d molecule, delta (CD3-TCR complex)Blood-1.640.000
85ABCA13ATP-binding cassette, sub-family A (ABC1), member 13Blood+1.640.002
86HIST2H2BFhistone cluster 2, H2bfBlood+1.640.000
87FEZ1fasciculation and elongation protein zeta 1 (zygin I)Blood-1.640.000
88UG0898H09uncharacterized LOC643763Blood+1.630.000
89DBNDD1dysbindin (dystrobrevin binding protein 1) domain containing 1Blood-1.620.000
90IFIH1interferon induced with helicase C domain 1Blood+1.620.000
91SAMD9Lsterile alpha motif domain containing 9-likeBlood+1.610.000
92ATP6V0E2-AS1ATP6V0E2 antisense RNA 1Blood+1.610.007
93HELZ2helicase with zinc finger 2, transcriptional coactivatorBlood+1.610.000
94COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)Blood-1.600.000
95MLKLmixed lineage kinase domain-likeBlood+1.600.000
96DHX58DEXH (Asp-Glu-X-His) box polypeptide 58Blood+1.590.000
97PTGDSprostaglandin D2 synthase 21kDa (brain)Blood-1.590.001
98SIGLEC5sialic acid binding Ig-like lectin 5Blood+1.590.000
99PDLIM5PDZ and LIM domain 5Blood+1.580.000
100RASSF2Ras association (RalGDS/AF-6) domain family member 2Blood+1.580.000
101IFIT2interferon-induced protein with tetratricopeptide repeats 2Blood+1.580.000
102TSC22D3TSC22 domain family, member 3Blood+1.580.000
103NTSR1neurotensin receptor 1 (high affinity)Blood+1.570.004
104CD1CCD1c moleculeBlood-1.570.001
105PRSS23protease, serine, 23Blood-1.570.001
106LIMK2LIM domain kinase 2Blood+1.570.000
107FAM13Afamily with sequence similarity 13, member ABlood+1.570.000
108IRF7interferon regulatory factor 7Blood+1.560.000
109KIAA1958KIAA1958Blood+1.550.000
110KLRC3killer cell lectin-like receptor subfamily C, member 3Blood-1.550.000
111GBP6guanylate binding protein family, member 6Blood+1.550.001
112C15orf48chromosome 15 open reading frame 48Blood+1.550.001
113LOC390933protein associated with topoisomerase II homolog 1 (yeast) pseudogeneBlood+1.550.000
114LINC00937long intergenic non-protein coding RNA 937Blood+1.540.002
115C1QCcomplement component 1, q subcomponent, C chainBlood+1.540.002
116USP9Yubiquitin specific peptidase 9, Y-linkedBlood-1.540.020
117CCNA1cyclin A1Blood+1.530.003
118LOC729732uncharacterized LOC729732Blood+1.530.001
119IL4interleukin 4Blood-1.530.001
120NTNG2netrin G2Blood+1.530.000
121CAMK2N1calcium/calmodulin-dependent protein kinase II inhibitor 1Blood-1.520.001
122CACNA2D2calcium channel, voltage-dependent, alpha 2/delta subunit 2Blood-1.510.000
123ANKRD22ankyrin repeat domain 22Blood+1.510.001
124PID1phosphotyrosine interaction domain containing 1Blood-1.500.002
125SLC1A3solute carrier family 1 (glial high affinity glutamate transporter), member 3Blood+1.500.000
126KRT72keratin 72Blood-1.500.032
127DGKZdiacylglycerol kinase, zetaBlood+1.490.001
128ARHGAP25Rho GTPase activating protein 25Blood+1.490.000
129NRCAMneuronal cell adhesion moleculeBlood-1.490.015
130IFIT5interferon-induced protein with tetratricopeptide repeats 5Blood+1.490.000
131BCL6B-cell CLL/lymphoma 6Blood+1.480.002
132TTTY15testis-specific transcript, Y-linked 15 (non-protein coding)Blood-1.480.042
133APOBEC3Bapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3BBlood+1.470.014
134PPP2R5Dprotein phosphatase 2, regulatory subunit B', deltaBlood+1.470.002
135NAP1L3nucleosome assembly protein 1-like 3Blood-1.470.000
136CCL8chemokine (C-C motif) ligand 8Blood+1.470.001
137C1orf186chromosome 1 open reading frame 186Blood-1.460.006
138LINC00982long intergenic non-protein coding RNA 982Blood-1.460.000
139CUX1cut-like homeobox 1Blood+1.450.002
140UNC93B1unc-93 homolog B1 (C. elegans)Blood+1.450.000
141TMEM30Btransmembrane protein 30BBlood-1.450.001
142FSD1Lfibronectin type III and SPRY domain containing 1-likeBlood+1.440.005
143MIR205HGMIR205 host gene (non-protein coding)Blood+1.440.002
144DNAAF1dynein, axonemal, assembly factor 1Blood+1.440.004
145DEFB1defensin, beta 1Blood+1.430.007
146GPR84G protein-coupled receptor 84Blood+1.430.002
147APOBEC3Aapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3ABlood+1.430.018
148DOC2Adouble C2-like domains, alphaBlood-1.420.005
149SELMselenoprotein MBlood-1.420.001
150MMP8matrix metallopeptidase 8 (neutrophil collagenase)Blood+1.420.035
151RTN3reticulon 3Blood+1.420.014
152IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)Blood+1.420.004
153PMEPA1prostate transmembrane protein, androgen induced 1Blood-1.420.027
154ELANEelastase, neutrophil expressedBlood+1.410.030
155ABCB4ATP-binding cassette, sub-family B (MDR/TAP), member 4Blood-1.410.025
156CXCL10chemokine (C-X-C motif) ligand 10Blood+1.410.003
157MCM7minichromosome maintenance complex component 7Blood+1.400.015
158ALDH3B1aldehyde dehydrogenase 3 family, member B1Blood+1.400.006
159CEACAM1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)Blood+1.400.000
160GAB2GRB2-associated binding protein 2Blood+1.400.000
161SOCS1suppressor of cytokine signaling 1Blood+1.400.002
162KLRB1killer cell lectin-like receptor subfamily B, member 1Blood-1.390.000
163FGF9fibroblast growth factor 9Blood-1.390.008
164EPHX4epoxide hydrolase 4Blood-1.380.003
165C1orf21chromosome 1 open reading frame 21Blood-1.380.017
166CD22CD22 moleculeBlood-1.380.027
167IGFBP3insulin-like growth factor binding protein 3Blood-1.370.015
168SLC1A7solute carrier family 1 (glutamate transporter), member 7Blood-1.360.014
169FCGBPFc fragment of IgG binding proteinBlood-1.360.032
170NBPF14neuroblastoma breakpoint family, member 14Blood+1.350.002
171NXNL1nucleoredoxin-like 1Blood+1.350.031
172ELOVL4ELOVL fatty acid elongase 4Blood-1.340.007
173NLRP12NLR family, pyrin domain containing 12Blood+1.340.009
174CACNA1Ecalcium channel, voltage-dependent, R type, alpha 1E subunitBlood+1.340.043
175KRT73keratin 73Blood-1.340.026
176SP3Sp3 transcription factorBlood+1.340.022
177FCER1AFc fragment of IgE, high affinity I, receptor for; alpha polypeptideBlood-1.340.012
178PDZD4PDZ domain containing 4Blood-1.340.006
179TRIM22tripartite motif containing 22Blood+1.340.000
180SALL2spalt-like transcription factor 2Blood-1.340.043
181EEF1B2eukaryotic translation elongation factor 1 beta 2Blood-1.330.000
182WSB1WD repeat and SOCS box containing 1Blood+1.330.000
183GATMglycine amidinotransferase (L-arginine:glycine amidinotransferase)Blood-1.330.023
184SORBS3sorbin and SH3 domain containing 3Blood-1.330.027
185PARP9poly (ADP-ribose) polymerase family, member 9Blood+1.330.000
186PNPT1polyribonucleotide nucleotidyltransferase 1Blood+1.330.000
187LOC390876ribosomal protein L35 pseudogeneBlood-1.320.041
188SPINK2serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)Blood-1.320.023
189KCTD14potassium channel tetramerization domain containing 14Blood+1.320.038
190TRIM78Ptripartite motif containing 78, pseudogeneBlood+1.320.001
191RPL14ribosomal protein L14Blood-1.320.004
192APOL1apolipoprotein L, 1Blood+1.310.019
193GBP1guanylate binding protein 1, interferon-inducibleBlood+1.310.004
194BTN3A1butyrophilin, subfamily 3, member A1Blood+1.310.013
195GNB4guanine nucleotide binding protein (G protein), beta polypeptide 4Blood+1.310.002
196TRIM5tripartite motif containing 5Blood+1.300.001
197FAPfibroblast activation protein, alphaBlood+1.300.010
198PARP12poly (ADP-ribose) polymerase family, member 12Blood+1.300.004
199LOC554223histocompatibility antigen-relatedBlood+1.300.033
200SLC16A11solute carrier family 16, member 11Blood-1.300.043
201DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 58Blood+1.290.003
202WDFY3WD repeat and FYVE domain containing 3Blood+1.290.011
203AKIRIN1akirin 1Blood+1.290.018
204TLR2toll-like receptor 2Blood+1.280.002
205ARSDarylsulfatase DBlood+1.280.012
206CAMTA1calmodulin binding transcription activator 1Blood-1.280.039
207MGC40069uncharacterized protein MGC40069Blood-1.270.040
208SGCEsarcoglycan, epsilonBlood-1.270.047
209PTGFRprostaglandin F receptor (FP)Blood+1.270.046
210ZNF365zinc finger protein 365Blood-1.270.038
211UBE2L6ubiquitin-conjugating enzyme E2L 6Blood+1.270.001
212KIAA0319LKIAA0319-likeBlood+1.270.002
213STAT1signal transducer and activator of transcription 1, 91kDaBlood+1.270.002
214DKK3dickkopf WNT signaling pathway inhibitor 3Blood-1.260.036
215IFI35interferon-induced protein 35Blood+1.260.008
216ZNF684zinc finger protein 684Blood+1.250.007
217LAP3leucine aminopeptidase 3Blood+1.250.013
218HIST1H4Dhistone cluster 1, H4dBlood+1.250.033
219FAM19A1family with sequence similarity 19 (chemokine (C-C motif)-like), member A1Blood-1.250.039
220USP4ubiquitin specific peptidase 4 (proto-oncogene)Blood+1.240.006
221NOMO3NODAL modulator 3Blood+1.230.036
222ABCB1ATP-binding cassette, sub-family B (MDR/TAP), member 1Blood-1.220.021
223BACH1BTB and CNC homology 1, basic leucine zipper transcription factor 1Blood+1.220.016
224LGR6leucine-rich repeat containing G protein-coupled receptor 6Blood-1.220.046
225MT2Ametallothionein 2ABlood+1.220.028
226SAMD9sterile alpha motif domain containing 9Blood+1.210.020
227MT1Gmetallothionein 1GBlood+1.210.041
228CREB5cAMP responsive element binding protein 5Blood+1.200.048
229BTN2A1butyrophilin, subfamily 2, member A1Blood+1.200.028
230PFN2profilin 2Blood-1.190.030
231GPR141G protein-coupled receptor 141Blood+1.180.047
232CDC42EP3CDC42 effector protein (Rho GTPase binding) 3Blood+1.180.032
233GALMgalactose mutarotase (aldose 1-epimerase)Blood+1.170.035
234TXNDC12thioredoxin domain containing 12 (endoplasmic reticulum)Blood-1.160.027


Search GEO for disease gene expression data for Systemic Lupus Erythematosus.

Pathways for genes affiliated with Systemic Lupus Erythematosus

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Pathways related to Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4FCGR2B, CR2, BANK1
2
Show member pathways
10.4CTLA4, PDCD1, PTPN22
3
Show member pathways
10.4TLR5, C3, STAT4
410.4C4B, C4A, C3
5
Show member pathways
10.4FCGR2B, STAT4, CR2, TLR5
6
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
10.4FCGR2B, PDCD1, CR2, CTLA4
710.4C4B, C4A, C3, FCGR2B
8
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
10.4C3, CR2, C4A, C4B
9
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
10.4C4B, C4A, CR2, C3

Compounds for genes affiliated with Systemic Lupus Erythematosus

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Sources:
45Novoseek, 26HMDB
See all sources

Compounds related to Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1agarose4510.6DNASE1, C3, C4A, C4B
2serine4510.6C4B, FCGR2B, STAT4, DNASE1, C3, CR2
3allergens4510.5STAT4, PDCD1, CTLA4
4phosphatidylinositol4510.5CTLA4, CR2, C3, STAT4, FCGR2B, TLR5
5thymine45 2611.5CTLA4, DNASE1
6tyrosine4510.5CTLA4, CR2, PDCD1, STAT4, FCGR2B, PTPN22
7aurintricarboxylic acid4510.5DNASE1, DNASE1L3
8estrogen4510.3FCGR2B, DNASE1, C3, CR2, CTLA4
9anaphylatoxin4510.1C4A, C3

GO Terms for genes affiliated with Systemic Lupus Erythematosus

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Cellular components related to Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:000588610.4TLR5, FCGR2B, C3, PDCD1, CR2, CTLA4
2blood microparticleGO:007256210.3C3, C4A, C4B
3external side of plasma membraneGO:000989710.1PDCD1, CR2, CTLA4

Biological processes related to Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1complement activation, classical pathwayGO:000695810.6C4B, C4A, CR2, C3
2regulation of complement activationGO:003044910.5C4B, C4A, C3
3innate immune responseGO:004508710.5TREX1, C4B, C4A, CR2, C3, TLR5
4DNA metabolic processGO:000625910.4DNASE1L3, TREX1
5complement activationGO:000695610.4C3, C4A, C4B
6inflammatory responseGO:000695410.3C4B, C4A, C3, TLR5
7immune responseGO:000695510.1CTLA4, CR2, C3, FCGR2B

Molecular functions related to Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:000486610.4C4B, C4A, C3

Products for genes affiliated with Systemic Lupus Erythematosus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Systemic Lupus Erythematosus

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet