MCID: SYS001
MIFTS: 87

Systemic Lupus Erythematosus malady

Summaries for Systemic Lupus Erythematosus

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8Disease Ontology, 3CDC, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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CDC:3 Systemic Lupus Erythematosus is an autoimmune disease in which the immune system produces antibodies to cells within the body leading to widespread inflammation and tissue damage. The causes of SLE are unknown but are believed to be linked to genetic, environmental, and hormonal factors. SLE may be characterized by periods of illness and remissions. SLE has a variety of clinical manifestations and can affect joints, skin, brain, lungs, kidneys, and blood vessels. People with SLE may experience fatigue, pain or swelling in joints, skin rashes, and fevers. A team approach in treating lupus is often warranted due to the number of organ systems involved.

MalaCards: Systemic Lupus Erythematosus, also known as lupus erythematosus, systemic, is related to lupus erythematosus and arthritis. An important gene associated with Systemic Lupus Erythematosus is TLR5 (toll-like receptor 5), and among its related pathways are Staphylococcus aureus infection and ErbB4 Pathway. The drugs azathioprine and cyclosporine and the compounds calcium and phosphatidylinositol have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and kidney, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart.

NINDS:43 Lupus (also called ) is a disorder of the immune system. Normally, the immune system protects the body against invading infections and cancers. In lupus, the immune system is over-active and produces increased amounts of abnormal antibodies that attack the body's tissues and organs. Lupus can affect many parts of the body, including the joints, skin, kidneys, lungs, heart, nervous system, and blood vessels. The signs and symptoms of lupus differ from person to person; the disease can range from mild to life threatening.

Wikipedia:63 Systemic lupus erythematosus i/sɪˈstɛmɪk ˈluːpəs ˌɛrɪθiːməˈtoʊsəs/, often abbreviated as... more...

Description from OMIM:46 152700,601744

Aliases & Classifications for Systemic Lupus Erythematosus

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8Disease Ontology, 43NINDS, 46OMIM, 10DISEASES, 30LifeMap Discovery™, 22GTR, 60UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:



Aliases & Descriptions:

systemic lupus erythematosus 8 43 46 10 30
lupus erythematosus, systemic 8 22 60
sle - lupus erythematosus, systemic 8
disseminated lupus erythematosus 8
lupus erythematosus systemic 44


External Ids:

Disease Ontology8 DOID:9074
NCIt39 C3201
MeSH34 D008180
OMIM46 152700
ICD9CM27 710.0
ICD1025 M32, M32.1

Related Diseases for Systemic Lupus Erythematosus

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Systemic Lupus Erythematosus family:

Lupus Erythematosus Dnase1-Related Susceptibility to Systemic Lupus Erythematosus
Cr2-Related Susceptibility to Systemic Lupus Erythematosus Systemic Lupus Erythematosus 14
Systemic Lupus Erythematosus 9 Systemic Lupus Erythematosus 1
Systemic Lupus Erythematosus 2 Systemic Lupus Erythematosus 16
Systemic Lupus Erythematosus 3 Systemic Lupus Erythematosus 13
Systemic Lupus Erythematosus 10 Systemic Lupus Erythematosus 12
Systemic Lupus Erythematosus 4 Systemic Lupus Erythematosus 5
Systemic Lupus Erythematosus 7 Systemic Lupus Erythematosus 8

Diseases related to Systemic Lupus Erythematosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 606)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus32.8C4A, TREX1, DNASE1, FCGR2B, C3
2arthritis31.8C3, PTPN22, CTLA4, FCGR2B, FCGR3A
3rheumatoid arthritis31.8TNFRSF13C, C3, PTPN22, FCGR3A, FCGR2B, FCRL3
4vasculitis31.4CTLA4, C3
5connective tissue disease31.3CTLA4, TREX1, DNASE1, FCGR2B, PTPN22, C3
6glomerulonephritis31.2C3
7hepatitis31.2CTLA4, FASLG
8complement deficiency31.1C3, C4A
9thrombocytopenia31.1FCGR2B, FCGR3A
10thyroiditis31.1FASLG, CTLA4, PTPN22
11lymphopenia31.1FASLG, PTPN22
12tuberculosis30.9C3, DNASE1
13myocardial infarction30.9DNASE1
14multiple sclerosis30.9PTPN22, STAT4, C4B, CTLA4, FASLG, TNFRSF13C
15sjogren's syndrome30.8FASLG
16myasthenia gravis30.8CTLA4
17dermatitis30.8CTLA4
18leukemia30.8FASLG, CR2, DNASE1
19autoimmune thyroiditis30.7FASLG, CTLA4, PTPN22
20hepatitis b30.5DNASE1
21acute myocardial infarction30.5DNASE1
22celiac disease30.5PTPN22, CTLA4
23asthma30.5DNASE1, STAT4, CTLA4
24graves' disease30.3FASLG, CTLA4, FCRL3, PTPN22
25vitiligo30.3PTPN22, C4B, CTLA4
26encephalomyelitis30.3STAT4, CTLA4, FASLG
27myeloma30.3DNASE1, FASLG
28wegener's granulomatosis30.3CTLA4
29psoriasis30.1TLR5, CTLA4, FCGR3A, PTPN22
30inflammatory bowel disease30.1PTPN22, STAT4, CTLA4, TLR5
31lupus nephritis30.1FCGR3A, DNASE1
32hyperthyroidism30.1PTPN22, CTLA4
33burkitt's lymphoma30.1FCGR2B, CR2, FASLG
34antiphospholipid syndrome11.1
35myelitis10.9
36atherosclerosis10.9
37protein-losing enteropathy10.9
38cutaneous lupus erythematosus10.8
39mixed connective tissue disease10.8
40purpura10.8
41scleroderma10.8
42systemic scleroderma10.8
43cerebritis10.8
44hypertension10.8
45retinitis10.8
46thrombotic thrombocytopenic purpura10.7
47klinefelter's syndrome10.7
48pure red-cell aplasia10.7
49vascular disease10.7
50dermatomyositis10.7

Graphical network of the top 20 diseases related to Systemic Lupus Erythematosus:



Diseases related to systemic lupus erythematosus

Clinical Features for Systemic Lupus Erythematosus

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46OMIM
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Clinical features from OMIM:

152700,601744

Clinical synopsis from OMIM:

152700

Drugs & Therapeutics for Systemic Lupus Erythematosus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Systemic Lupus Erythematosus

Drug clinical trials:

Search ClinicalTrials for Systemic Lupus Erythematosus

Search NIH Clinical Center for Systemic Lupus Erythematosus

Search CenterWatch for Systemic Lupus Erythematosus

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Systemic Lupus Erythematosus cell therapies at LifeMap Discovery.

Genetic Tests for Systemic Lupus Erythematosus

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22GTR
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Genetic tests related to Systemic Lupus Erythematosus:

id Genetic test Affiliating Genes
1 Systemic Lupus Erythematosus22

Anatomical Context for Systemic Lupus Erythematosus

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Systemic Lupus Erythematosus:

32
T cells, Skin, Kidney, B cells, Heart, Lung, Endothelial, Brain, Monocytes, Bone, Thyroid, Liver, Testes, Bone marrow, Breast, Pituitary, Myeloid, Whole blood, Spleen, Nk cells, Colon, Spinal cord, Placenta, Prostate, Uterus, Skeletal muscle, Eye, Temporal lobe, Pineal, Salivary gland, Smooth muscle

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Systemic Lupus Erythematosus:
id TissueAnatomical CompartmentCell Relevance
1 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Systemic Lupus Erythematosus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Systemic Lupus Erythematosus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538713.3C3, TLR5, TNFRSF13C, FASLG, CTLA4, C4B
2MP:000539713.1C4B, CTLA4, FASLG, TNFRSF13C, TLR5, CR2
3MP:000537613.0C4B, CTLA4, FASLG, TNFRSF13C, TLR5, CR2
4MP:000538412.6TLR5, TNFRSF13C, FASLG, CTLA4, CR2, STAT4
5MP:001076812.4CTLA4, C4B, CR2, STAT4, TREX1, DNASE1
6MP:000536712.3FASLG, C4B, CR2, STAT4, TREX1, DNASE1
7MP:000537012.1TLR5, FASLG, CTLA4, C4B, TREX1, FCGR2B
8MP:000538111.7TLR5, FASLG, CTLA4, C4B, TREX1, FCGR2B
9MP:000538811.3TLR5, FASLG, CTLA4, TREX1, FCGR2B, PTPN22

Publications for Systemic Lupus Erythematosus

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50PubMed
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Articles related to Systemic Lupus Erythematosus:

(show top 50)    (show all 4420)
idTitleAuthorsYear
1
Soluble E-cadherin in systemic lupus erythematosus. (23996289)
2013
2
Feasibility of transcatheter aortic valve implantation in systemic lupus erythematosus associated non-calcific aortic stenosis. (24014217)
2013
3
Effect of Xuebijing injection on systemic lupus erythematosus in mice. (23975132)
2013
4
Occurrence of Hashimoto thyroiditis among the first- and second-degree relatives of systemic lupus erythematosus patients with Hashimoto thyroiditis. (24192566)
2013
5
Lymphopenia Helps Early Diagnosis of Systemic Lupus Erythematosus for Patients With Psychosis as an Initial Symptom. (24070661)
2013
6
IKZF1: a critical role in the pathogenesis of systemic lupus erythematosus? (22782532)
2013
7
Promising biomarkers for systemic lupus erythematosus. (24099307)
2013
8
Incidence of cancer in a cohort of Spanish patients with systemic lupus erythematosus. (24099959)
2013
9
Cranial nerve palsies: sarcoidosis to systemic lupus erythematosus. (23401835)
2013
10
Coronary Artery Bypass Grafting in a Patient Initially Presenting with Systemic Lupus Erythematosus. (23995344)
2013
11
Spleen tyrosine kinase (Syk) regulates systemic lupus erythematosus (SLE) T cell signaling. (24013589)
2013
12
CD28 proximal promoter polymorphisms in systemic lupus erythematosus susceptibility. (21544637)
2012
13
Altered AKT1 and MAPK1 gene expression on peripheral blood mononuclear cells and correlation with T-helper-transcription factors in systemic lupus erythematosus patients. (23125486)
2012
14
Association analysis of polymorphisms in lumican gene and systemic lupus erythematosus in a Taiwan Chinese Han population. (21885486)
2011
15
Elevated circulating CD4+ ICOS+ Foxp3+ T cells contribute to overproduction of IL-10 and are correlated with disease severity in patients with systemic lupus erythematosus. (21558138)
2011
16
Aberrant splicing of the milk fat globule-EGF factor 8 (MFG-E8) gene in human systemic lupus erythematosus. (20213738)
2010
17
The informative value of determination of serum IL-1beta, IL-6, IFN-gamma in systemic lupus erythematosus]. (19338090)
2009
18
Effect of yangyin jiedu huoxue recipe on hormone withdrawal and disease activity in patients with systemic lupus erythematosus]. (19960971)
2009
19
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. (19838193)
2009
20
Systemic lupus erythematosus and discoid lupus erythematosus. (18940631)
2008
21
Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: support for the notion of a gene-dose effect from the X chromosome. (18668569)
2008
22
Case report: disseminated dermatophytosis by microsporum gypseum in a systemic lupus erythematosus patient. (24031171)
2008
23
Revisiting Jaccoud arthropathy as an ultrasound diagnosed erosive arthropathy in systemic lupus erythematosus. (18176140)
2007
24
Antibodies toward high-density lipoprotein components inhibit paraoxonase activity in patients with systemic lupus erythematosus. (17893980)
2007
25
Identification of distinct gene expression profiles in the synovium of patients with systemic lupus erythematosus. (17469140)
2007
26
Libman-Sacks endocarditis in systemic lupus erythematosus: prevalence, associations, and evolution. (17602939)
2007
27
Soluble receptors of TNF-alpha: association with atherosclerotic vascular affection in systemic lupus erythematosus in males]. (16881358)
2006
28
Identification and characterization of an Xp22.33;Yp11.2 translocation causing a triplication of several genes of the pseudoautosomal region 1 in an XX male patient with severe systemic lupus erythematosus. (16575839)
2006
29
Trace elements and some extracellular antioxidant proteins levels in serum of patients with systemic lupus erythematosus. (15583971)
2005
30
The intricate role of complement component C4 in human systemic lupus erythematosus. (14719377)
2004
31
Polymorphisms of toll-like receptor 2 and 4 genes in rheumatoid arthritis and systemic lupus erythematosus. (14651524)
2004
32
The biallelic variable number of tandem repeats of the tumor necrosis factor receptor 2 promoter in systemic lupus erythematosus. (12739039)
2003
33
Deoxyribonuclease I gene expression in systemic lupus erythematosus patients]. (14669213)
2003
34
A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans. (12402038)
2002
35
Development of systemic lupus erythematosus following autologous bone marrow transplant for acute lymphocytic leukemia. (11409148)
2001
36
Systemic lupus erythematosus, complement deficiency, and apoptosis. (11079100)
2000
37
Automated detection of anti-double-stranded DNA antibody in systemic lupus erythematosus serum by flow immunoassay. (10204035)
1999
38
Porphyria cutanea tarda in a patient with systemic lupus erythematosus. (10556280)
1999
39
Antinuclear antibody negative systemic lupus erythematosus presenting as bilateral facial paralysis. (9558189)
1998
40
Scabies Norwegian Associated With High IgE and Low IgG1 Levels Presenting as Systemic Lupus Erythematosus. (11101917)
1998
41
Decreased production of interleukin-12 and other Th1-type cytokines in patients with recent-onset systemic lupus erythematosus. (9588735)
1998
42
Relationship between endocrine, immune, and clinical variables in patients with systemic lupus erythematosus. (9415637)
1997
43
Systemic lupus erythematosus with acanthosis nigricans, hyperpigmentation, and insulin receptor antibody. (9104736)
1997
44
Association of anticardiolipin antibodies and pregnancy loss in women with systemic lupus erythematosus. (8375525)
1993
45
Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis. (2051017)
1991
46
Interferon-gamma induced exacerbation of systemic lupus erythematosus. (2117660)
1990
47
Anterior spinal artery syndrome in systemic lupus erythematosus. (2743095)
1989
48
Complement receptor (CR1) deficiency in erythrocytes from patients with systemic lupus erythematosus. (6978375)
1982
49
Subcutaneous chromoblastomycosis occurring in a patient with systemic lupus erythematosus. (588195)
1977
50
Proceedings: Various types of antilymphocyte antibodies in patients with systemic lupus erythematosus (SLE) and their relationship with lymphopenia. (1137619)
1975

Genetic Variations for Systemic Lupus Erythematosus

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Systemic Lupus Erythematosus:

62
id Symbol AA change Variation ID SNP ID
1TREX1p.Arg169HisVAR_028319
2TREX1p.Ala213ValVAR_037949
3TREX1p.Gly282SerVAR_037950rs113107733
4TREX1p.Arg295SerVAR_037951rs72556555
5TREX1p.Ala302ProVAR_037952rs112741962
6TREX1p.Pro345LeuVAR_037954
7TREX1p.Tyr360CysVAR_037955
8TREX1p.Gly361AlaVAR_037956

Expression for genes affiliated with Systemic Lupus Erythematosus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Systemic Lupus Erythematosus

Search GEO for disease gene expression data for Systemic Lupus Erythematosus.

Pathways for genes affiliated with Systemic Lupus Erythematosus

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29KEGG, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 55SinoBiological
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Pathways related to Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.4C3, FCGR3A, FCGR2B, C4B, C4A
2
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11.2FCGR2B, STAT4, CR2, TLR5
3
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11.2FCGR3A, FCGR2B, CR2, FASLG
4
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11.2C3, CR2, C4B, C4A
5
Immune response Lectin induced complement pathway
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11.2C4A, C4B, CR2, C3
6
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11.2C4A, C4B, CR2, C3
7
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11.2TLR5, FASLG, STAT4, C3
8
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11.2C4A, C4B, FCGR3A, C3
9
Hide members
11.2TLR5, STAT4, FCGR3A, C3
1011.0C4A, C4B, C3
11
Hide members
11.0FCGR2B, FCGR3A, C3
1210.9C3, C4A

Compounds for genes affiliated with Systemic Lupus Erythematosus

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2415.5TNFRSF13C, FASLG, CTLA4, C4B, CR2, DNASE1
2phosphatidylinositol4412.3TLR5, FASLG, CTLA4, CR2, STAT4, FCGR2B
3tyrosine4412.3TLR5, FASLG, CTLA4, CR2, STAT4, FCGR2B
4estrogen4411.9FASLG, CTLA4, CR2, DNASE1, FCGR2B, C3
5Intravenous Immunoglobulin1111.8C3, FCGR3A, FCGR2B, C4B, C4A
6agarose4411.8FASLG, C4A, C4B, DNASE1, C3
7rituximab44 49 1113.6FASLG, CTLA4, FCGR2B, FCGR3A
8serine4411.4C3, FCGR2B, CTLA4
9ivig4411.4FASLG, FCGR2B, FCGR3A
10paraffin4411.2DNASE1L3, DNASE1, CR2, FASLG
11Palivizumab1111.2FCGR3A, FCGR2B
12Ibritumomab1111.1FCGR2B, FCGR3A
13bevacizumab49 1112.1FCGR2B, FCGR3A
14dexamethasone44 49 28 1114.1FASLG, CTLA4, STAT4, DNASE1, C3
15tositumomab49 1112.1FCGR2B, FCGR3A
16alefacept44 1112.1FCGR3A, FCGR2B
17Muromonab1111.1FCGR2B, FCGR3A
18efalizumab44 1112.1FCGR2B, FCGR3A
19aurintricarboxylic acid4411.0DNASE1, DNASE1L3
20daclizumab44 1112.0FCGR3A, FCGR2B
21basiliximab44 1112.0FCGR2B, FCGR3A
22gemtuzumab ozogamicin44 1111.9FCGR3A, FCGR2B
23natalizumab44 1111.9FCGR2B, FCGR3A
24alemtuzumab44 1111.8FCGR2B, FCGR3A

GO Terms for genes affiliated with Systemic Lupus Erythematosus

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16Gene Ontology
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Cellular components related to Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989711.4FCGR3A, CR2, CTLA4, FASLG, TNFRSF13C

Biological processes related to Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508711.9TLR5, C4A, C4B, CR2, TREX1, FCGR3A
2immune responseGO:00695511.7FASLG, CTLA4, CR2, FCGR2B, FCGR3A, C3
3complement activation, classical pathwayGO:00695811.4C3, CR2, C4B, C4A
4inflammatory responseGO:00695411.2C3, C4B, C4A, TLR5
5regulation of complement activationGO:03044911.0C3, C4B, C4A
6complement activationGO:00695610.9C4A, C4B, C3
7regulation of immune responseGO:05077610.7C3, FCGR3A, FCGR2B

Molecular functions related to Systemic Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:01986410.9FCGR3A, FCGR2B
2endopeptidase inhibitor activityGO:00486610.7C3, C4B, C4A

Products for genes affiliated with Systemic Lupus Erythematosus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Systemic Lupus Erythematosus

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet