Systemic Lupus Erythematosus malady

CDC: Systemic Lupus Erythematosus is an autoimmune disease in which the immune system produces antibodies to cells within the body leading to widespread inflammation and tissue damage. The causes of SLE are unknown but are believed to be linked to genetic, environmental, and hormonal factors. SLE may be characterized by periods of illness and remissions. SLE has a variety of clinical manifestations and can affect joints, skin, brain, lungs, kidneys, and blood vessels. People with SLE may experience fatigue, pain or swelling in joints, skin rashes, and fevers. A team approach in treating lupus is often warranted due to the number of organ systems involved.²

MalaCards: Systemic Lupus Erythematosus, also known as lupus erythematosus, systemic, is related to lupus erythematosus and leukemia. An important gene associated with Systemic Lupus Erythematosus is TLR5 (toll-like receptor 5), and among its related pathways are Immune System and Tec Kinases Signaling. The drugs azathioprine and triamcinolone and the compounds calcium and atp have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are cellular and homeostasis/metabolism.

Disease Ontology: A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart.⁶

NINDS: Lupus (also called ) is a disorder of the immune system. Normally, the immune system protects the body against invading infections and cancers. In lupus, the immune system is over-active and produces increased amounts of abnormal antibodies that attack the body's tissues and organs. Lupus can affect many parts of the body, including the joints, skin, kidneys, lungs, heart, nervous system, and blood vessels. The signs and symptoms of lupus differ from person to person; the disease can range from mild to life threatening.³¹

Wikipedia: Systemic lupus erythematosus (i/sɪˈstɛmɪk ˈluːpəs ˌɛrɪθiːməˈtoʊsəs/), often abbreviated...⁴⁴ more...

OMIM: 152700

Aliases & Descriptions:

systemic lupus erythematosus 6 31 8 33 lupus erythematosus, systemic 6 43 sle - lupus erythematosus, systemic 6 disseminated lupus erythematosus 6

lupus erythematosus systemic 32 lupus erythematosus 43

Disease types for systemic lupus erythematosus family:

systemic lupus erythematosus 2	systemic lupus erythematosus 10
systemic lupus erythematosus 9	systemic lupus erythematosus 1
systemic lupus erythematosus 14	systemic lupus erythematosus 3
systemic lupus erythematosus 7	systemic lupus erythematosus 8
systemic lupus erythematosus 4	systemic lupus erythematosus 13
systemic lupus erythematosus 5	systemic lupus erythematosus 12

Diseases related to systemic lupus erythematosus by text searches and GeneDecks gene sharing:

(show top 50)    (show all 977)

id	Related Disease	Score	Top Affiliating Genes
1	lupus erythematosus	219.1	ZNF311, PIK3CD, PIGF, PIK3C2A, PIK3CG, WDFY4
2	leukemia	115.8	PIK3CD, PIK3C2A, PIK3CG, SH2B3, COG2, NCF2
3	neuronitis	79.6	PIK3CD, PIK3C2A, PIK3CG, NCF2, NCL, RECK
4	pancreatitis	77.6	PIK3CD, PIK3C2A, PIK3CG, RGL2, NCF2, NCL
5	thyroiditis	75.4	PIGF, PIK3C2A, PIK3CG, COG2, RECK, RETN
6	atherosclerosis	69.3	PIK3C2A, PIK3CG, WDFY4, LRRC18, COG2, NCF2
7	carcinoma	68.8	PIK3CD, PIGF, PIK3C2A, PIK3CG, NCF2, NCL
8	lymphocytic leukemia	67.0	PIK3CD, PIK3CG, NCL, PDCD1LG2, RECK, REL
9	non-hodgkin lymphoma	65.4	NCF2, PDCD1, REL, KIR2DS3, KIR2DS5, KIR2DL1
10	fibrosis	64.7	PIK3CG, NCF2, RECK, RETN, VWF, VTN
11	diabetes mellitus	64.4	PIK3CD, PIK3C2A, PIK3CG, SH2B3, COG2, PDCD1
12	anemia	63.2	PDCD1, VWF, SELE, SELL, SELP, SERPINC1
13	nephritis	62.4	PDCD1, VWF, VTN, RBP4, SELE, SELP
14	cerebritis	61.0	PIGF, PIK3C2A, PIK3CG, COG2, CNTF, VWF
15	inflammatory bowel disease	60.7	RETN, KIR2DL1, KIR2DL3, VWF, RBP4, SELE
16	pneumonia	60.4	PIK3C2A, COG2, VTN, RDBP, RBP4, SELE
17	nephropathy	59.8	COG2, PDCD1, RETN, VWF, VTN, RBP4
18	sjogren's syndrome	59.4	PIK3C2A, PDCD1, RETN, KIR2DS3, KIR2DS5, KIR2DL1
19	myocardial infarction	57.4	PIK3C2A, PIK3CG, SH2B3, COG2, PDCD1, RECK
20	cholesterol	57.4	PIK3CD, PIK3C2A, PIK3CG, COG2, NCF2, RECK
21	hypertension	57.1	PIK3C2A, PIK3CG, SH2B3, COG2, REEP2, RETN
22	purpura	57.1	RECK, VWF, SELE, SELP, SERPINC1, SERPINE1
23	immunodeficiency	57.0	PIK3CD, PDCD1, KIR3DL1, SELL, LMOD1, MYD88
24	vasculitis	56.4	SH2B3, PDCD1, VWF, SELE, SELL, SELP
25	lupus nephritis	55.0	PDCD1, VWF, VTN, RBP4, SELE, SERPINE1
26	sarcoidosis	54.4	PIK3C2A, KIR2DL3, VTN, BTNL2, SELE, SELL
27	systemic lupus erythematosus, association with	53.6	PDCD1, KIR2DS5, KIR3DS1, KIR2DS2, SERPINE1, BANK1
28	glomerulonephritis	53.4	VWF, VTN, RBP4, SELP, SERPINC1, SERPINE1
29	thrombosis	53.1	PIK3C2A, PIK3CG, COG2, RECK, RETN, VWF
30	celiac disease	52.9	SH2B3, REL, KIR3DL1, KIR2DL5A, SELE, SELL
31	graves' disease	52.8	PDCD1, PDCD1LG2, RETN, KIR2DS3, KIR2DS5, KIR2DL1
32	thrombocytopenia	52.3	PIK3C2A, RECK, VWF, SELE, SELL, SELP
33	retinitis	52.1	PIGF, PIK3C2A, PIK3CG, CNTF, VWF, VTN
34	osteoarthritis	50.2	PIK3CG, RETN, VTN, BTNL2, SERPINB2, SERPINE1
35	cystic fibrosis	49.6	PIK3CG, RECK, VWF, RBP4, SELL, SELP
36	sepsis	48.6	RECK, RETN, VTN, RBP4, SELE, SELL
37	prostatitis	48.4	PIK3CD, PIK3C2A, PIK3CG, NCL, PDCD1, RECK
38	insulin resistance	48.4	PIK3CG, COG2, RETN, CNTF, VWF, RBP4
39	myocarditis	48.1	PIK3C2A, SELP, SERPINC1, LPL, CLU, CIITA
40	leishmaniasis	47.1	PIK3C2A, NCF2, LPA, MYD88, BMP6, CIITA
41	spondylitis	47.1	PDCD1, PDCD1LG2, KIR2DS3, KIR2DS5, KIR2DP1, KIR2DL1
42	noonan syndrome	47.1	PIK3C2A, PIK3CG, RETN, VWF, SELP, SERPINC1
43	myopathy	46.9	PIK3C2A, SELE, SEPN1, BRD2, VCAM1, BOK
44	gonococcal synovitis	46.5	PIK3CG, PDCD1, RECK, REL, RETN, CNTF
45	coronary heart disease	45.5	PIK3C2A, COG2, RETN, VWF, SELE, SELL
46	neutropenia	45.2	LMOD1, LIF, CLIC1, BCL2, CISH, XRCC3
47	antiphospholipid syndrome	45.1	VWF, SELE, SELP, SERPINC1, SERPINE1, VEGFA
48	acute myocardial infarction	44.8	PIK3C2A, PIK3CG, COG2, RETN, CNTF, VWF
49	dermatomyositis	44.6	PIK3C2A, VWF, VTN, SELE, SERPINA3, VEGFA
50	wegener's granulomatosis	44.2	VWF, BTNL2, SELE, SERPINE1, SERPINA3, SERPINB1

Clinical features from OMIM: 152700

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 azathioprine, cyclosporine, hydroxychloroquine, hydroxychloroquine sulfate, triamcinolone, triamcinolone acetonide, triamcinolone acetonide pwdr [va product], triamcinolone diacetate, triamcinolone hexacetonide

MalaCards organs/tissues related to systemic lupus erythematosus:

²²

MGI Mouse Phenotypes related to systemic lupus erythematosus:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular phenotype	MP:0005384	46.1	PIK3CD, PIK3CG, SH2B3, PDCD1, PDCD1LG2, REL
2	homeostasis/metabolism phenotype	MP:0005376	40.7	PIK3CD, PIK3C2A, PIK3CG, PDCD1LG2, REL, RETN
3	mortality/aging	MP:0010768	39.1	PIK3C2A, PDCD1, PDCD1LG2, RECK, REL, VWF
4	hematopoietic system phenotype	MP:0005397	37.9	SH2B3, PDCD1, PDCD1LG2, CNTF, BTLA, SERPINB2
5	immune system phenotype	MP:0005387	32.2	PIK3CD, REL, CNTF, VWF, BTLA, SELL
6	growth/size phenotype	MP:0005378	28.3	PIK3C2A, PIK3CG, RECK, REL, SELE, SELP
7	cardiovascular system phenotype	MP:0005385	26.0	PIK3CD, PIK3CG, PDCD1, RECK, REL, VWF
8	nervous system phenotype	MP:0003631	23.1	PDCD1, RECK, REL, CNTF, VWF, RDX
9	behavior/neurological phenotype	MP:0005386	22.7	CNTF, RDX, SELE, SELP, SEZ6L2, NAGLU
10	normal phenotype	MP:0002873	22.2	VTN, RBP4, SELE, SEZ6L2, SERPING1, SEPN1
11	integument phenotype	MP:0010771	20.1	PIK3CG, RECK, REL, SELP, LMNB1, MYC
12	digestive/alimentary phenotype	MP:0005381	19.9	REL, VWF, VEGFA, VDR, VAV1, MYC
13	tumorigenesis	MP:0002006	19.6	PDCD1LG2, SELL, SERPINE1, MYC, MYD88, RAG2
14	reproductive system phenotype	MP:0005389	18.8	RBP4, NAT1, VEGFA, VDR, VAV1, RAG2
15	liver/biliary system phenotype	MP:0005370	18.7	RECK, REL, RETN, RDX, SERPINC1, BRD2
16	renal/urinary system phenotype	MP:0005367	18.4	PDCD1, SELP, NAGLU, MYD88, RAG1, RASGRP1
17	respiratory system phenotype	MP:0005388	17.1	REL, SELL, SELP, SERPINB1, LPL, RAG2
18	vision/eye phenotype	MP:0005391	16.8	PDCD1, RBP4, SELE, SELP, SERPINC1, NAGLU
19	embryogenesis phenotype	MP:0005380	16.4	RECK, REL, SERPINC1, NAT1, BRD2, LMNB1
20	no phenotypic analysis	MP:0003012	16.4	PIK3CD, PDCD1LG2, VEGFA, VCAM1, MYC, MYD88
21	muscle phenotype	MP:0005369	15.7	PIK3CG, PDCD1, CNTF, RBP4, SERPINB2, SEPN1
22	endocrine/exocrine gland phenotype	MP:0005379	15.5	SELL, BRD2, PATZ1, ZEB1, LDLR, XRCC4
23	skeleton phenotype	MP:0005390	15.1	PIK3CD, PIK3CG, RECK, REL, SEPN1, NAGLU
24	craniofacial phenotype	MP:0005382	15.0	NAGLU, LPAR1, LMNB1, RAG2, PBX2, BDNF
25	hearing/vestibular/ear phenotype	MP:0005377	13.1	RDX, NAGLU, VDR, MYC, MYD88, RAG1
26	limbs/digits/tail phenotype	MP:0005371	12.6	RECK, VEGFA, VDR, ZEB1, LEP, CHKB
27	adipose tissue phenotype	MP:0005375	11.7	PIK3C2A, RETN, SERPINE1, BRD2, LPAR1, LPL
28	other phenotype	MP:0005395	11.5	SH2B3, RECK, CLU, ZFP57, KDR, LDLR

Articles related to systemic lupus erythematosus:

(show top 50)    (show all 2058)

id	Title	Authors	Year	Affiliating Genes
1	Association of BLK (rs13277113, rs2248932) polymorphi sm with systemic lupus erythematosus: a meta-analysis. (21152986)	Fan Y.... Ye D.Q.	2011	BLK
2	Functional polymorphisms of the coagulation factor II gene (F2) and susceptibility to systemic lupus erythematosus. (21239755)	Demirci F.Y.... Kamboh M.I.	2011	F2
3	Expression of humoral autoimmunity is related to andr ogen receptor CAG repeat length in men with systemic lupus erythematosus. (21445561)	Tessnow A.H.... Kovacs W.J.	2011	AR
4	Nuclear magnetic resonance lipoprotein subclasses and the APOE genotype influence carotid atherosclerosis in patients with systemic lupus erythematosus. (20682673)	GonzA lez M.... Castro A.	2010	APOE
5	Functional monocyte chemoattractant protein-1 promote r -2518 polymorphism and systemic lupus erythematosus: a meta-analysis. (19941075)	Lee Y.H.... Song G.G.	2010	CCL2
6	Calcyphylaxis in a patient with end-stage renal dise ase in the course of systemic lupus erythematosus, diagnostic problems--case re port (19856878)	Gebska E.... Jarzab J.	2009	CRP
7	Genetic, immunologic, and immunohistochemical analysis of the programmed death 1/programmed death ligand 1 pathway in human systemic lupus erythematosus. (19116915)	Bertsias G.K.... Boumpas D.T.	2009	PDCD1, CD274
8	Haplotypes of the HRES-1 endogenous retrovirus are associated with development and disease manifestations of systemic lupus erythematosus. (18240231)	Pullmann R.... Perl A.	2008	HRES1
9	Effect of disease activity and position on autonomic nervous modulation in patients with systemic lupus erythematosus. (17940721)	Huang S.T.... Kuo C.D.	2008	ALB
10	Association of three systemic lupus erythematosus susceptibility factors, PD-1.3A, C4AQ0, and low levels of mannan-binding lectin, with autoimmune manifestations in Icelandic multicase systemic lupus erythematosus families. (19035512)	Kristjansdottir H.... Steinsson K.	2008	MBL2, PDCD1, C4A
11	Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95. (18512812)	Jacobi A.M.... Dorner T.	2008	FAS, CD27
12	HLA-G genotype and HLA-G expression in systemic lupus erythematosus: HLA-G as a putative susceptibility gene in systemic lupus erythematosus. (18380776)	Rizzo R.... Baricordi O.R.	2008	HLA-G
13	Interleukin-10 promoter polymorphisms in patients with systemic lupus erythematosus from the Canary Islands. (18397303)	Rosado S.... Perez-Aciego P.	2008	IL10
14	Phenotypes, genotypes and disease susceptibility associated with gene copy number variations: complement C4 CNVs in European American healthy subjects and those with systemic lupus erythematosus. (19287147)	Wu Y.L.... Yu C.Y.	2008	C4A
15	Role of pathogenic auto-antibody production by Toll-like receptor 9 of B cells in active systemic lupus erythematosus. (18160420)	Nakano S.... Takasaki Y.	2008	TLR9
16	A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population. (18219441)	Oishi T.... Matsuda K.	2008	ITPR3, NKX2-5
17	Von Willebrand factor, red cell fragmentation, and disease activity in systemic lupus erythematosus. (18815861)	Curiel R.V.... Weinstein A.	2008	VWF
18	Effect of prolactin on lymphocyte activation from systemic lupus erythematosus patients. (17893982)	Chavez-Rueda K.... Blanco-Favela F.	2007	PRL
19	Overexpression of human decoy receptor 3 in mice results in a systemic lupus erythematosus-like syndrome. (17968950)	Han B.... Luo H.	2007	TNFRSF6B
20	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population. (17728371)	Puah S.M.... Tan S.Y.	2007	C4B, C4A
21	Complementarity-determining region 3 analysis of T cell receptor beta chain variable region in peripheral blood mononuclear cells of patients with systemic lupus erythematosus (16939900)	Luo W.... Wang X.N.	2006	TRB@
22	Association of a transmembrane polymorphism of Fcgamma receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patients. (17133600)	Chen J.Y.... Wu J.	2006	FCGR2B
23	Adrenomedullin--a potential disease activity marker and suppressor of nephritis activity in systemic lupus erythematosus. (16595522)	Mak A.... Lau C.S.	2006	ADM
24	Glutathione S-transferase genotype and risk of systemic lupus erythematosus in Koreans. (15934438)	Kang T.Y.... Bae S.C.	2005	GSTP1, GSTT1, GSTM1
25	Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease. (16052563)	Wu H.... Tsao B.P.	2005	PTPN22
26	Trace elements and some extracellular antioxidant proteins levels in serum of patients with systemic lupus erythematosus. (15583971)	Yilmaz A.... Dag E.	2005	TF, ALB, CP
27	Possible role of leptin in hypoandrogenicity in patients with systemic lupus erythematosus and rheumatoid arthritis. (15194576)	HAorle P.... Straub R.H.	2004	LEP, LSL
28	Expression of CD80/CD86 and CTLA-4 mRNA in peripheral blood mononuclear cells of the patients with systemic lupus erythematosus. (15315339)	Liu W.... Li J.	2004	CTLA4
29	Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus. (14695357)	Li N.... Hirose S.	2004	LTK
30	The biallelic variable number of tandem repeats of the tumor necrosis factor receptor 2 promoter in systemic lupus erythematosus. (12739039)	Lee Y.H.... Song G.G.	2003	TNFRSF1B
31	The putative role of apoptosis-modified histones for the induction of autoimmunity in Systemic Lupus Erythematosus. (14555219)	Gabler C.... Lorenz H.M.	2003	ANXA5
32	Association of Fcgamma receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais. (12753656)	Siriboonrit U.... Tokunaga K.	2003	FCGR2B, FCGR3B
33	A study of the relationship between MICA gene and systemic lupus erythematosus (12170466)	Ban G.... Zhang S.	2002	MICA
34	Serum adenosine deaminase and cytidine deaminase activities in patients with systemic lupus erythematosus. (12113294)	Taysi S.... Bakan E.	2002	ADA, CDA
35	Linkage analysis of angiotensin-converting enzyme (ACE) insertion/deletion polymorphism and systemic lupus erythematosus. (11377823)	Kaufman K.M.... Harley J.B.	2001	ACE
36	Pyrexia and normal C-reactive protein (CRP) in patien ts with systemic lupus erythematosus: always consider the possibility of infect ion in febrile patients with systemic lupus erythematosus regardless of CRP lev els. (11285392)	Roy S.... Tan K.T.	2001	CRP
37	Interleukin-10 blockade corrects impaired in vitro cellular immune responses of systemic lupus erythematosus patients. (11014347)	Lauwerys B.R.... Houssiau F.A.	2000	IL10
38	Genome screening in human systemic lupus erythematosus: results from a second Minnesota cohort and combined analyses of 187 sib-pair families. (10677315)	Gaffney P.M.... Behrens T.W.	2000	SLEB3, SLEB2, SLEB1
39	Lymphocytic hypophysitis in a patient with systemic lupus erythematosus. (10728449)	Ji J.D.... Song G.G.	2000	PRL
40	A prospective analysis of cognitive function and anticardiolipin antibodies in systemic lupus erythematosus. (10211887)	Hanly J.G.... Fisk J.D.	1999	APOH
41	Restrictions of T cell receptor beta chain repertoire in the peripheral blood of patients with systemic lupus erythematosus. (8882133)	Holbrook M.R.... Powell R.J.	1996	TRB@
42	Cytokine production (IL-6 and TNF alpha) in whole blood cell cultures of patients with systemic lupus erythematosus. (8792800)	Swaak A.J.... Aarden L.A.	1996	TNF, IL6
43	Systemic lupus erythematosus: calciphylaxis induced cardiomyopathy. (7699668)	MacLean C.... Brahn E.	1995	PIK3C2A
44	Endothelin-1 release from cultured endothelial cells induced by sera from patients with systemic lupus erythematosus. (7794041)	Yoshio T.... Kano S.	1995	EDN1
45	Anti-5S RNA/protein (RNP) antibody levels correlate with disease activity in a patient with systemic lupus erythematosus (SLE) nephritis. (8137536)	Guialis A.... Moutsopoulos H.M.	1994	RPL5, RNPC3
46	Bcl-2 and Fas, molecules which influence apoptosis. A possible role in systemic lupus erythematosus? (7524704)	Rose L.M.... Isenberg D.A.	1994	FAS
47	Distinguishing beta 2-glycoprotein I dependent (systemic lupus erythematosus type) and independent (syphilis type) anticardiolipin antibody with Tween 20. (7918046)	Matsuda J.... Tsukamoto M.	1993	APOH
48	Low levels of total cholesterol, high-density lipoprotein, and apolipoprotein A1 in association with anticardiolipin antibodies in patients with systemic lupus erythematosus. (8240433)	Lahita R.G.... Romano P.	1993	APOH
49	Repeated intestinal ulcerations in a patient with systemic lupus erythematosus and high serum antiphospholipid antibody levels. (2014444)	Sasamura H.... Yamamoto M.	1991	F2
50	Detection of autoantibodies to Sm antigen in systemic lupus erythematosus by immunodiffusion, ELISA and immunoblotting: variability of incidence related to assays and ethnic origin of patients. (2146135)	Abuaf N.... Buri J.F.	1990	LSM2

Genes related to systemic lupus erythematosus according to GeneCards:

(show top 50)    (show all 1075)

id	Symbol	Description	Score	GeneCards Section Context
1	TLR5	toll-like receptor 5	11.1	Publications, Summaries
2	SLEB12	Systemic lupus erythematosus, susceptibility to, 12	11.1	Aliases & Descriptions
3	SLEB13	Systemic lupus erythematosus, susceptibility to, 13	11.1	Aliases & Descriptions
4	SLEB14	Systemic lupus erythematosus, susceptiblity to, 14	11.1	Aliases & Descriptions
5	SLEB5	Systemic lupus erythematosus, susceptibility to, 5	11.1	Aliases & Descriptions
6	SLEB7	Systemic lupus erythematosus, susceptibility to, 7	11.1	Aliases & Descriptions
7	SLEB8	Systemic lupus erythematosus, susceptibility to, 8	11.1	Aliases & Descriptions
8	SLEB4	systemic lupus erythematosus, susceptibility to, 4	11.1	Publications, Aliases & Descriptions
9	SLEB3	systemic lupus erythematosus susceptibility 3	11.1	Publications, Aliases & Descriptions
10	C4A	complement component 4A (Rodgers blood group)	11.1	Publications, Pathways & Interactions, Summaries
11	FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	11.1	Publications, Pathways & Interactions, Summaries
12	CR2	complement component (3d/Epstein Barr virus) receptor 2	11.1	Publications, Summaries
13	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	11.1	Publications, Summaries
14	SLEN1	systemic lupus erythematosus with nephritis 1	11.1	Aliases & Descriptions, Publications
15	SLEN2	systemic lupus erythematosus with nephritis 2	11.1	Publications, Aliases & Descriptions
16	SLEN3	systemic lupus erythematosus with nephritis 3	11.1	Aliases & Descriptions, Publications
17	SLEB2	systemic lupus erythematosus susceptibility 2	11.1	Publications, Aliases & Descriptions
18	SLEB1	systemic lupus erythematosus susceptibility 1	11.1	Publications, Aliases & Descriptions
19	DNASE1	deoxyribonuclease I	11.1	Publications, Summaries
20	BANK1	B-cell scaffold protein with ankyrin repeats 1	11.1	Publications, Summaries
21	FASLG	Fas ligand (TNF superfamily, member 6)	11.1	Publications, Summaries
22	SLEH1	systemic lupus erythematosus with hemolytic anemia 1	11.1	Publications, Aliases & Descriptions
23	FCGR3A	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	11.1	Publications, Pathways & Interactions, Summaries
24	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.1	Publications, Functions, Summaries
25	CALR	calreticulin	11.1	Publications, Summaries
26	LOC100293534	complement C4-B-like	11.1	Publications, Summaries
27	GIMAP5	GTPase, IMAP family member 5	11.1	Publications, Summaries
28	SLEV1	systemic lupus erythematosus, vitiligo-related 1	11.1	Aliases & Descriptions, Publications
29	C4B	complement component 4B (Chido blood group)	11.1	Publications, Pathways & Interactions, Summaries
30	DNASE1L3	deoxyribonuclease I-like 3	11.1	Publications, Summaries
31	FCRL3	Fc receptor-like 3	11.1	Publications, Summaries
32	FOXJ1	forkhead box J1	11.1	Publications, Summaries
33	SSB	Sjogren syndrome antigen B (autoantigen La)	11.1	Publications, Pathways & Interactions, Summaries
34	STAT4	signal transducer and activator of transcription 4	11.1	Publications, Summaries
35	TNFRSF13C	tumor necrosis factor receptor superfamily, member 13C	11.1	Publications, Summaries
36	FCN3	ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)	11.1	Publications, Summaries
37	SNRPB	small nuclear ribonucleoprotein polypeptides B and B1	11.1	Publications, Pathways & Interactions, Summaries
38	TNIP1	TNFAIP3 interacting protein 1	11.1	Publications, Summaries
39	CR1	complement component (3b/4b) receptor 1 (Knops blood group)	11.1	Publications, Summaries
40	RASGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	11.1	Publications, Summaries
41	RPL7	ribosomal protein L7	11.1	Publications, Summaries
42	TRIM21	tripartite motif containing 21	11.1	Publications, Pathways & Interactions, Summaries
43	C3	complement component 3	11.1	Publications, Pathways & Interactions, Summaries
44	C5AR1	complement component 5a receptor 1	11.1	Publications, Summaries
45	MAN2A1	mannosidase, alpha, class 2A, member 1	11.1	Publications, Summaries
46	XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	11.1	Orthologs, Summaries
47	CAT	catalase	11.1	Publications, Summaries
48	IRF5	interferon regulatory factor 5	11.0	Publications
49	PDCD1	programmed cell death 1	11.0	Publications
50	RNY1	RNA, Ro-associated Y1	11.0	Summaries

Pathways related to systemic lupus erythematosus according to GeneDecks:

(show top 50)    (show all 218)

id	Pathway	Score	Top Affiliating Genes
1	Immune System38	22.0	PDCD1, PDCD1LG2, REL, KIR2DS5, KIR2DL1, KIR2DL3
2	Tec Kinases Signaling36	20.7	VAV1, MYD88, BMP6, BDNF, BCL2, LCP2
3	Antioxidant Action of Vitamin-C36	20.5	NCF2, BMP6, LIF, BDNF, KDR, BCL2
4	ERK Signaling36	19.4	MYC, BMP6, CHUK, ZAP70, LAMC2, LAT
5	Tuberculosis20	18.8	VDR, MYD88, BCL2, CIITA, BAX, LAMP1
6	Akt Signaling36	18.4	PIK3CG, LIF, CHUK, AXL, CD28, CD2
7	MAPK Family Pathway36	17.6	BMP6, BDNF, KDR, BCL2, CHUK, BAX
8	JAK-STAT Pathway36	17.3	MYC, BMP6, BDNF, KDR, BCL2, UBD
9	Histone modification10	16.9	H2AFX, H2AFZ, H3F3A, H3F3B, HIST1H1B, HIST1H2AC
10	Leishmaniasis20	16.1	NCF2, MYD88, JUN, ITGA4, ITGAM, ITGB1
11	Natural killer cell mediated cytotoxicity20	16.0	PIK3CD, PIK3CG, NCR3, KIR2DS3, KIR2DS5, KIR2DL1
12	Glucocorticoid Receptor Signaling36	16.0	BMP6, BCL2, BAX, CEBPB, JUN, CDKN1A
13	Complement and coagulation cascades20	15.8	VWF, SERPINC1, SERPINE1, SERPING1, CFB, CFI
14	MIF Mediated Glucocorticoid Regulation36	15.8	BMP6, LIF, BCL2, BAX, CD2, CD14
15	all-trans-Retinoic Acid Signaling in Brain36	15.7	BMP6, LIF, BCL2, BAX, CD2, CD80
16	Lymphocyte Signaling3	15.4	NCF2, MYD88, RAG1, BLK, PAX5, CIITA
17	Endothelin-1 Signaling Pathway36	15.2	MYC, BMP6, AXL, CD2, CD80, FLT1
18	TGF-Beta Pathway36	15.2	BMP6, BDNF, KDR, BCL2, BAX, JUN
19	IL-6 Pathway36	15.1	BMP6, BAX, CD2, CD80, IL10, IL12A
20	Jak-STAT signaling pathway20	15.1	PIK3CD, PIK3CG, CNTF, MYC, LEP, CISH
21	Immune response NFAT in immune response10	15.0	PIK3CD, REL, VAV1, CHUK, ZAP70, LCK
22	PGC1Alpha Pathway36	14.9	BMP6, BCL2, BAX, CD2, CD4, CD80
23	Chagas disease (American trypanosomiasis)20	14.9	PIK3CD, PIK3CG, SERPINE1, MYD88, CHUK, CFLAR
24	Autoimmune thyroid disease20	14.8	CGA, CD28, CD86, CD40LG, CD80, CD40
25	Toll-like receptor signaling pathway20	14.7	PIK3CD, PIK3CG, MYD88, CHUK, JUN, CD86
26	NF-KappaB Family Pathway36	14.6	REL, VAV1, MYD88, BMP6, BLK, BDNF
27	Nuclear Receptor Activation by Vitamin-A36	14.6	BMP6, BDNF, KDR, FLT1, GTF2H4, IL2
28	SOCS Pathway36	14.4	BMP6, BCL2, CISH, BAX, CD2, CD4
29	TRAF Pathway36	14.3	MYD88, CHUK, UBD, UBC, JUN, FOS
30	NF-kappaB Signaling3	14.3	REL, MYD88, CHUK, IRAK1, IRAK4, IRF1
31	Immune response_IL-22 signaling pathway41	14.2	MYC, BCL2, JUN, CD28, CD86, CD4
32	Immune response IL-22 signaling pathway10	14.1	MYC, BCL2, JUN, CD28, CD86, CD4
33	NF-KappaB (p50-p65) Pathway36	14.1	MYD88, BMP6, BDNF, KDR, CHUK, UBD
34	CD28 Signaling in T-Helper Cell36	14.1	PIK3C2A, VAV1, ZAP70, LCP2, LAT, FYN
35	Immune response T cell receptor signaling pathway10	14.0	REL, VAV1, RASGRP1, ZAP70, LCK, LCP2
36	Crosstalk Between CARM1 and ESRs36	13.8	GTF2H4, ESR1, ESR2, TBP, H3F3A, H3F3B
37	Asthma20	13.7	MS4A2, CD40LG, CD40, IL10, IL13, IL3
38	Immune response_NFAT in immune response41	13.6	PIK3CD, LCP2, LAT, MS4A2, CD28, CD247
39	TNF Superfamily Pathway36	13.6	CHUK, JUN, FOS, FADD, MAPK8, CASP3
40	NFAT Signaling and Lymphocyte Interactions36	13.6	BMP6, BCL2, BAX, CD2, CD4, CD80
41	T cell receptor signaling pathway20	13.5	PIK3CD, PIK3CG, PDCD1, VAV1, RASGRP1, CHUK
42	Immune response_ICOS pathway in T-helper cell41	13.3	PIK3CD, PIK3CG, REL, ZAP70, LCP2, LAT
43	CTL Mediated Apoptosis36	13.3	GZMB, FADD, CASP3, HLA-A, HLA-B, HLA-C
44	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway10	13.1	REL, BCL2, BCL2A1, CHUK, CD40LG, CD40
45	14-3-3 Induced Apoptosis36	13.1	MYD88, BCL2, CHUK, YWHAB, JUN, FOS
46	Cytosolic DNA-sensing pathway20	12.8	CHUK, IRF3, IRF7, IL18, IL1B, IL33
47	Immune response_Bacterial infections in normal airways41	12.3	REL, MYD88, CHUK, CD14, IRAK1, IRAK4
48	Bacterial infections in CF airways41	12.1	REL, MYD88, CHUK, IRAK1, IRAK4, IRF1
49	Selected targets of GCR-alpha10	12.1	LEP, CGA, CDKN1A, INS, INSR, IL1B
50	Renin-Angiotensin Pathway36	11.2	VCAM1, BMP6, BDNF, KDR, CHUK, JUN

Compounds related to systemic lupus erythematosus according to GeneDecks:

(show top 50)    (show all 453)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	39.4	PIK3CD, PIK3C2A, COG2, NCF2, NCL, RECK
2	atp32	23.5	PIK3C2A, NCF2, NCL, RECK, KIR3DL1, VTN
3	cholesterol32 9 18 9	24.8	PIK3C2A, COG2, RECK, RETN, VWF, VTN
4	creatinine32	21.1	RETN, VWF, RBP4, SELE, SELL, SELP
5	superoxide32 18	21.4	PIK3C2A, NCF2, CNTF, SELL, SERPINB2, SERPINA3
6	lactate32	19.2	PIK3C2A, RECK, VWF, VTN, RBP4, SELE
7	methotrexate32 34 42 9 9	20.4	PIK3C2A, SELE, SERPINE1, SERPINA3, NAGLU, NAT2
8	homocysteine32 18	17.0	PIK3C2A, COG2, RETN, VWF, SELE, SELP
9	glucose32	15.7	CNTF, NAGA, LMAN1, CLEC12A, CISH, CHUK
10	paraffin32	15.4	VWF, SELL, SERPINB2, SERPINA3, VEGFA, VCAM1
11	estradiol32 9 18 9	18.3	SERPINE1, SERPINA3, BOK, LIF, PAPPA, BDNF
12	infliximab32 9 9	17.3	SELE, VEGFA, BGLAP, LBR, ITGA4, MMP1
13	etanercept32 9 9	16.7	LEP, MMP1, MMP3, FCGR1A, FCGR2A, FCGR2B
14	formaldehyde32 18	15.5	VWF, SELE, SELL, SELP, LGALS3, CHGA
15	12-o-tetradecanoylphorbol 13-acetate32	14.4	CNTF, SERPINB2, MYC, BMP6, RAG1, LIF
16	matrigel32	14.4	PIGF, PIK3CG, VWF, VTN, SELE, SERPINB2
17	pentoxifylline32 9 9	16.3	SELL, SELP, NAGLU, VCAM1, BMP6, LBR
18	p00232	14.3	RETN, RBP4, LPA, PAPPA, SCGB1A1, LEP
19	dopamine32 9 18 9	17.1	CNTF, RBP4, SELE, SERPINA3, NAGLU, LMOD1
20	herbimycin a32 42	14.8	PIK3CG, VTN, SELE, SELL, VCAM1, VAV1
21	calcitriol32 42 9 18 9	17.7	VDR, MYC, BMP6, LIF, CLU, BGLAP
22	tarc32	13.7	CD4, ITGA4, IL10, IL13, IL18, IL1A
23	con a32	13.6	SERPINA3, LBR, CD28, CD79A, CD2, CD69
24	2,5-oligoadenylate32	13.6	MYC, MX1, B2M, ISG15, ISG20, IRF1
25	heparan sulfate32 18	14.4	NCL, VTN, SERPINC1, SERPINE1, NAGLU, LPL
26	anti-fungal32	13.4	REL, CHGA, CD79A, CDR1, CD40LG, CDKN3
27	gold32	13.4	PIK3C2A, RECK, RBP4, SERPINA3, NAGLU, CHGA
28	natalizumab32 9 9	15.3	ITGA4, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A
29	manganese superoxide32	13.2	REL, SERPINB2, VCAM1, XRCC1, CD14, CD40
30	thyroxine32 18	14.1	PIK3C2A, COG2, RETN, VWF, RBP4, SERPINA3
31	adenine32 9 18 9	16.0	VWF, NAT1, NAT2, SCGB1A1, LEP, LDLR
32	warfarin32 34 9 18 9	17.0	PIK3C2A, VWF, SELP, SERPINC1, NAT2, LPA
33	pravastatin32 34 9 18 9	16.9	PIK3C2A, COG2, SELE, SELP, SERPINE1, LPA
34	n acetylcysteine32	12.9	VWF, SELE, SELP, SERPINC1, NAGLU, VCAM1
35	fluvastatin32 34 9 9	15.9	PIK3C2A, COG2, VWF, SELP, SERPINE1, LPL
36	glycerol32 9 18 9	15.6	PIK3C2A, VWF, SERPINC1, NAGA, LPAR1, LPL
37	polysulfone32	12.5	VWF, SELL, SELP, VCAM1, B2M, CD14
38	sulfasalazine32 9 9	14.5	SELE, NAT2, CHUK, MTHFR, MPO, CD79A
39	nadph32 18	13.0	MYD88, XRCC1, ASS1, GRIN2A, FCGR3B, HSD17B8
40	doxycycline32 9 9	13.8	SCGB1A1, CD79A, CD40LG, MMP1, MMP2, MMP3
41	pmma32	11.4	VTN, SELP, BMP6, B2M, CD40LG, CCL3
42	ceramide32	11.3	ANXA5, TNF, SYK
43	4-hydroxytamoxifen32	11.1	MYC, CLU, PARP1, S100B, JUN, FASLG
44	diphenyleneiodonium32	11.1	NCF2, VEGFA, VCAM1, XDH, MPO, JUN
45	agar32	11.1	CD40LG
46	mg 13232 42	11.8	PIK3CG, VDR, MYC, PARP1, KDR, UBE2L3
47	rottlerin32 42	11.7	PIK3CG, VCAM1, PARP1, JUN, CD36, CD40LG
48	c2ceramide32	10.4	PIK3CG, PARP1, CHUK, BAX, CGB5, JUN
49	pioglitazone32 9 9	12.2	COG2, RETN, RBP4, VEGFA, LPL, VCAM1
50	geldanamycin32 9 9	11.6	PIK3CG, VEGFA, PARP1, KDR, LCK, CFLAR

Cellular components related to systemic lupus erythematosus according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	40.1	PIK3CD, PIK3C2A, PIK3CG, PDCD1, PDCD1LG2, RECK
2	extracellular region	GO:005576	29.2	PDCD1LG2, RETN, KIR3DP1, VWA7, VWF, VTN
3	extracellular space	GO:005615	25.7	CNTF, VTN, RBP4, SELE, SELP, SERPINC1
4	integral to plasma membrane	GO:005887	24.3	NCR3, KIR2DS3, KIR2DS5, KIR2DL1, KIR2DL3, KIR2DL4
5	cytosol	GO:005829	23.7	PIK3CD, PIK3C2A, PIK3CG, SH2B3, NCF2, REL
6	external side of plasma membrane	GO:009897	20.2	VWF, BTLA, SELL, SELP, VCAM1, LILRB1
7	nucleosome	GO:000786	17.2	CENPA, H2AFJ, H2AFV, H2AFX, H2AFY, H2AFY2
8	nucleoplasm	GO:005654	15.8	REL, RDBP, RBMX, VDR, LMNB1, MYC
9	cell surface	GO:009986	15.2	VEGFA, LPAR1, LPL, VCAM1, LDLR, AXL
10	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	13.2	CALR, HLA-A, HLA-B, HLA-C, HLA-DPA1, HLA-DPB1
11	MHC class II protein complex	GO:042613	13.0	HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1
12	ER to Golgi transport vesicle membrane	GO:012507	13.0	LMAN1, B2M, HLA-A, HLA-B, HLA-C, HLA-DPA1
13	membrane raft	GO:045121	13.0	SELE, LCK, LAT, P2RX7, MS4A2, CD79A
14	endosome membrane	GO:010008	12.8	VPS52, MYD88, LDLR, UBC, LAMP1, CD14
15	clathrin-coated endocytic vesicle membrane	GO:030669	12.2	LDLR, FCGR1A, APOB, HLA-DPA1, HLA-DPB1, HLA-DQA1
16	platelet alpha granule lumen	GO:031093	11.5	VWF, SERPINE1, SERPING1, VEGFA, CLU, FGA

Biological processes related to systemic lupus erythematosus according to GeneDecks:

(show top 50)    (show all 74)

id	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:006955	27.2	NCR3, PDCD1LG2, KIR2DS5, KIR2DL1, KIR2DL3, KIR3DS1
2	signal transduction	GO:007165	22.2	PIK3CD, PDCD1, CNTF, KIR2DL4, LPXN, VDR
3	innate immune response	GO:045087	20.7	PIK3CD, PIK3CG, NCF2, SERPING1, MYD88, CLEC4C
4	inflammatory response	GO:006954	20.1	PIK3CD, PIK3CG, NCR3, SELE, SELP, SERPINA3
5	cytokine-mediated signaling pathway	GO:019221	18.2	VCAM1, MYD88, CIITA, MX1, UBC, B2M
6	nucleosome assembly	GO:006334	17.9	BRD2, CENPA, H2AFB1, H2AFB2, H2AFJ, H2AFV
7	apoptotic process	GO:006915	16.8	PDCD1, BOK, LMNB1, VAV1, BCL2, BCL2A1
8	blood coagulation	GO:007596	16.3	PIK3CG, SH2B3, KIFC1, VWF, SELL, SELP
9	positive regulation of transcription from RNA polymerase II promoter	GO:045944	15.9	RBMX, SERPINE1, VEGFA, VDR, MYC, MYD88
10	response to virus	GO:009615	15.8	MYD88, LILRB1, CLU, CHUK, MX1, FOXP3
11	interferon-gamma-mediated signaling pathway	GO:060333	15.5	VCAM1, CIITA, B2M, CD44, IRF1, IRF3
12	regulation of immune response	GO:050776	15.5	KIR2DL1, KIR2DL3, KIR2DL4, KIR3DL1, KIR2DS2, KIR2DS1
13	T cell costimulation	GO:031295	15.4	PDCD1, PDCD1LG2, BTLA, VAV1, LCK, FYN
14	cell-cell signaling	GO:007267	15.3	S100A9, CGA, CGB, CD70, CD86, CD80
15	complement activation, classical pathway	GO:006958	15.2	SERPING1, CLU, CFI, CD55, CD46, MBL2
16	cell surface receptor signaling pathway	GO:007166	15.0	MYD88, P2RX7, MPL, CD28, CD2, CD27
17	virus-host interaction	GO:019048	14.4	VCAM1, KDR, LDLR, LCK, BAX, CFLAR
18	complement activation	GO:006956	14.2	CLU, CFB, CFHR1, CFP, MBL2, IGHG1
19	anti-apoptosis	GO:006916	14.1	SERPINB2, MYD88, BDNF, BCL2, BCL2A1, UBC
20	response to lipopolysaccharide	GO:032496	14.1	NCF2, SELE, SELP, S100A8, S100A9, P2RX7
21	platelet activation	GO:030168	14.1	PIK3CG, VWF, SELP, SERPINE1, SERPING1, VEGFA
22	induction of apoptosis	GO:006917	14.0	BOK, MX1, LCK, BAX, CEBPB, CD2
23	defense response to virus	GO:051607	13.9	LILRB1, BCL2, CD86, CD40, ITGAX, IRF1
24	response to hypoxia	GO:001666	13.9	VEGFA, VCAM1, BCL2, LEP, XRCC1, CD24
25	positive regulation of inflammatory response	GO:050729	13.8	SERPINE1, IL12B, IL15, IL18, IL1RL1, IL2
26	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	13.8	REL, LPAR1, MYD88, LGALS9, CHUK, UBD
27	type I interferon-mediated signaling pathway	GO:060337	13.8	MX1, ISG15, ISG20, IRF1, IRF3, IRF4
28	leukocyte migration	GO:050900	13.7	SELL, SELP, LCK, MSN, FYN, CD2
29	positive regulation of cell proliferation	GO:008284	13.6	CNTF, VEGFA, MYC, LIF, KDR, LEP
30	positive regulation of interleukin-12 production	GO:032735	13.2	CD36, CD40LG, CD40, IRF8, IL12B, IL23A
31	cellular response to lipopolysaccharide	GO:071222	13.2	SERPINE1, LILRB1, AXL, CD36, CD14, ASS1
32	T cell receptor signaling pathway	GO:050852	13.1	PIK3CD, CHUK, ZAP70, UBC, LCK, LCP2
33	response to drug	GO:042493	13.1	NCF2, LPL, MYC, BGLAP, BDNF, BCL2
34	negative regulation of interferon-gamma production	GO:032689	13.0	LILRB1, SCGB1A1, AXL, FOXP3, IL10, IL1RL1
35	positive regulation of T cell proliferation	GO:042102	12.9	PDCD1LG2, VCAM1, CD28, ITGAL, IL12A, IL12B
36	aging	GO:007568	12.9	NCF2, VDR, VCAM1, JUN, ASS1, IL15
37	positive regulation of NF-kappaB transcription factor activity	GO:051092	12.9	MYD88, CLU, CHUK, UBC, CD40, IRAK1
38	positive regulation of tumor necrosis factor production	GO:032760	12.8	MYD88, CD36, CD14, IL12B, IL18, IL23A
39	positive regulation of interferon-gamma production	GO:032729	12.8	CD40LG, IRF8, IL12A, IL12B, IL12RB1, IL18
40	positive regulation of apoptotic process	GO:043065	12.6	LPAR1, LILRB1, CLU, UBD, BAX, P2RX7
41	positive regulation of interleukin-8 production	GO:032757	12.4	SERPINE1, IL18, IL1B, FADD, MAVS, CALCA
42	positive regulation of interleukin-6 production	GO:032755	12.2	MYD88, P2RX7, CD36, IL1A, IL1B, IL33
43	positive regulation of B cell proliferation	GO:030890	12.1	BCL2, CDKN1A, CD40LG, CD40, CD38, MIF
44	negative regulation of apoptotic process	GO:043066	12.0	PIK3CG, SERPINE1, VEGFA, MYC, CLU, KDR
45	response to ethanol	GO:045471	12.0	RBP4, BGLAP, BCL2, S100A8, S100A9, FYN
46	lipopolysaccharide-mediated signaling pathway	GO:031663	12.0	MYD88, IRAK1, IRF3, IL18, IL1B, CCL2
47	platelet degranulation	GO:002576	11.9	VWF, SELP, SERPINE1, SERPING1, VEGFA, CLU
48	leukocyte cell-cell adhesion	GO:007159	11.8	SELE, SELP, VCAM1, MSN, CD40LG, ITGA4
49	positive regulation of nitric oxide biosynthetic process	GO:045429	11.2	INS, INSR, IL1B, IFNG, ICAM1, HSP90AA1
50	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.5	VTN, VEGFA, LIF, CD36, CD4, CD80

Molecular functions related to systemic lupus erythematosus according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	44.6	ACTN2, TOP1, TLR2, TLR4, TIA1, TIMP1
2	cytokine activity	GO:005125	15.9	TNFSF13, TNFSF13B, TNFSF4, SPP1, LTA, LTB
3	receptor activity	GO:004872	15.7	TNFRSF6B, TNFRSF17, TNFRSF13B, TNFRSF11B, TNFRSF11A, TREM1
4	receptor binding	GO:005102	14.9	CD70, CD72, ITGB2, MLN, FLT3LG, MIF
5	protein homodimerization activity	GO:042803	14.9	NOS2, RPL7, COL25A1, NFKB1, SHBG, C1QB
6	transmembrane signaling receptor activity	GO:004888	13.8	ICAM1, TNFRSF10C, TNFRSF11A, TNFRSF8, CR2, KLRC1
7	tumor necrosis factor receptor binding	GO:005164	12.4	TNFSF13, TNFSF13B, TNFSF4, LTA, LTB, STAT1
8	heparin binding	GO:008201	12.3	TNXB, PTPRC, CTSG, COMP, COL25A1, LTF
9	chemokine activity	GO:008009	12.3	CX3CL1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13
10	MHC class II receptor activity	GO:032395	12.2	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB2, HLA-DQB1
11	protease binding	GO:002020	11.3	F3, HSPA1B, TP53, TNF, TNFAIP3, TNFRSF1A
12	growth factor activity	GO:008083	11.3	TGFB3, TGFB2, TGFB1, NGF, PPBP, F2
13	enzyme binding	GO:019899	11.1	NOTCH1, NOD2, PLSCR1, SNRPD3, PPARG, CUTA