MCID: SYS001
MIFTS: 86

Systemic Lupus Erythematosus

Categories: Genetic diseases, Rare diseases, Nephrological diseases, Immune diseases, Bone diseases, Skin diseases

Aliases & Classifications for Systemic Lupus Erythematosus

MalaCards integrated aliases for Systemic Lupus Erythematosus:

Name: Systemic Lupus Erythematosus 54 38 12 25 51 71 29 3 14
Lupus Nephritis 54 12 50 52 42 14 69
Lupus Erythematosus, Systemic 12 42 69
Disseminated Lupus Erythematosus 12 25
Libman-Sacks Disease 25 69
Sle 25 71
Sle - Lupus Erythematosus, Systemic 12
Lupus Erythematosus Systemic 52
Lupus Erythematosus, Discoid 69
Lupus Erythematosus 69
Lupus Vulgaris 69
Le Syndrome 25
Lupus 25

Characteristics:

OMIM:

54
Inheritance:
autosomal dominant

Miscellaneous:
complement deficiency (e.g. c2 and c4 null alleles) are susceptible to developing sle
association between hla class ii alleles and presence of autoantibodies
onset between ages 16-55
female to male ratio 8-13:1


HPO:

32
systemic lupus erythematosus:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Systemic Lupus Erythematosus

NINDS : 51 Lupus (also called systemic lupus erythematosus) is a disorder of the immune system. Normally, the immune system protects the body against invading infections and cancers. In lupus, the immune system is over-active and produces increased amounts of abnormal antibodies that attack the body's tissues and organs. Lupus can affect many parts of the body, including the joints, skin, kidneys, lungs, heart, nervous system, and blood vessels. The signs and symptoms of lupus differ from person to person; the disease can range from mild to life threatening. Initial symptoms of lupus may begin with a fever, vascular headaches, epilepsy, or psychoses. A striking feature of lupus is a butterfly shaped rash over the cheeks. In addition to headache, lupus can cause other neurological disorders, such as mild cognitive dysfunction, organic brain syndrome, peripheral neuropathies, sensory neuropathy, psychological problems (including personality changes, paranoia, mania, and schizophrenia), seizures, transverse myelitis, and paralysis and stroke.

MalaCards based summary : Systemic Lupus Erythematosus, also known as lupus nephritis, is related to systemic lupus erythematosus 1 and rheumatoid arthritis, and has symptoms including seizures, thrombocytopenia and leukopenia. An important gene associated with Systemic Lupus Erythematosus is PTPN22 (Protein Tyrosine Phosphatase, Non-Receptor Type 22), and among its related pathways/superpathways are Systemic lupus erythematosus and Innate Immune System. The drugs Simvastatin and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include Umbilical Cord, t cells and skin, and related phenotypes are hematopoietic system and immune system

NIH Rare Diseases : 50 lupus nephritis is a kidney disorder that is a complication of systemic lupus erythematous (sle), commonly known as lupus. the symptoms of lupus nephritis include blood in the urine, a foamy appearance to the urine, high blood pressure, and swelling in any part of the body. this condition typically occurs in people aged 20 to 40 years. treatment may involve medications to suppress the immune system, dialysis, or a kidney transplant. visit our web page on lupus for more information and resources. last updated: 11/24/2010

UniProtKB/Swiss-Prot : 71 Systemic lupus erythematosus: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

CDC : 3 Lupus occurs when an unknown trigger causes a person’s own immune system to attack their tissues, damaging the tissues and producing widespread inflammation. There is no known cause or cure for lupus; however, treatments are available.

Genetics Home Reference : 25 Systemic lupus erythematosus (SLE) is a chronic disease that causes inflammation in connective tissues, such as cartilage and the lining of blood vessels, which provide strength and flexibility to structures throughout the body. The signs and symptoms of SLE vary among affected individuals, and can involve many organs and systems, including the skin, joints, kidneys, lungs, central nervous system, and blood-forming (hematopoietic) system. SLE is one of a large group of conditions called autoimmune disorders that occur when the immune system attacks the body's own tissues and organs.

OMIM : 54
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. Tissue deposition of antibodies or immune complexes induces inflammation and subsequent injury of multiple organs and finally results in clinical manifestations of SLE, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and arthritis. Evidence strongly suggests the involvement of genetic components in SLE susceptibility (summary by Oishi et al., 2008). (152700)

Disease Ontology : 12 A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart.

Wikipedia : 72 Systemic lupus erythematosus (SLE), also known simply as lupus, is an autoimmune disease in which the... more...

Related Diseases for Systemic Lupus Erythematosus

Diseases in the Lupus Erythematosus family:

Systemic Lupus Erythematosus Systemic Lupus Erythematosus 14
Systemic Lupus Erythematosus 9 Systemic Lupus Erythematosus 1
Systemic Lupus Erythematosus 11 Systemic Lupus Erythematosus 2
Systemic Lupus Erythematosus 16 Systemic Lupus Erythematosus 3
Systemic Lupus Erythematosus 13 Systemic Lupus Erythematosus 10
Systemic Lupus Erythematosus 12 Systemic Lupus Erythematosus 4
Systemic Lupus Erythematosus 5 Systemic Lupus Erythematosus 7
Systemic Lupus Erythematosus 8 Systemic Lupus Erythematosus 15
Cr2-Related Susceptibility to Systemic Lupus Erythematosus Dnase1-Related Susceptibility to Systemic Lupus Erythematosus
Itgam-Related Susceptibility to Systemic Lupus Erythematosus

Diseases related to Systemic Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 799, show less)
id Related Disease Score Top Affiliating Genes
1 systemic lupus erythematosus 1 35.6 TLR5 TREX1
2 rheumatoid arthritis 32.8 CD40LG CTLA4 IL10 PTPN22 STAT4
3 lymphoma 32.2 CD40LG CTLA4 IL10 SSB TLR9 TRIM21
4 myasthenia gravis 32.1 CD40LG FCGR2B PTPN22
5 malaria 31.4 CD40LG CR1 CTLA4 FCGR2A FCGR2B IL10
6 granuloma annulare 31.2 C4A C4B CD40LG CR1 TLR9
7 pseudohypoparathyroidism 31.1 CD40LG CTLA4 IL10 PTPN22 STAT4 TLR9
8 facial paralysis 30.7 CD40LG IL10
9 systemic lupus erythematosus 16 12.6
10 systemic lupus erythematosus 2 12.4
11 systemic lupus erythematosus 10 12.4
12 systemic lupus erythematosus 9 12.4
13 pediatric systemic lupus erythematosus 12.3
14 systemic lupus erythematosus 11 12.3
15 systemic lupus erythematosus 3 12.2
16 systemic lupus erythematosus 12 12.2
17 systemic lupus erythematosus 4 12.2
18 systemic lupus erythematosus 5 12.2
19 lupus erythematosus 12.2
20 systemic lupus erythematosus with nephritis 3 12.1
21 systemic lupus erythematosus with nephritis 2 12.1
22 systemic lupus erythematosus 14 12.1
23 systemic lupus erythematosus 13 12.1
24 systemic lupus erythematosus 7 12.1
25 systemic lupus erythematosus 8 12.1
26 systemic lupus erythematosus with nephritis 1 12.1
27 systemic lupus erythematosus 15 12.1
28 neonatal systemic lupus erythematosus 12.0
29 cr2-related susceptibility to systemic lupus erythematosus 12.0
30 dnase1-related susceptibility to systemic lupus erythematosus 12.0
31 itgam-related susceptibility to systemic lupus erythematosus 12.0
32 systemic lupus erythematous, association with 6 11.7
33 vitiligo-associated multiple autoimmune disease susceptibility 1 11.6
34 c1q deficiency 11.6
35 mixed connective tissue disease 11.5
36 neonatal lupus erythematosus 11.5
37 pure red-cell aplasia 11.3
38 humero-ulnar synostosis 11.3 C4A C4B PTPN22 STAT4
39 drug-induced lupus erythematosus 11.3
40 sjogren's syndrome 11.3
41 macrophage activation syndrome 11.3
42 macroglobulinemia, waldenstrom 1 11.3 CTLA4 IL10 PTPN22 STAT4
43 epidermolysis bullosa acquisita 11.3
44 collagen disease 11.3
45 combined cellular and humoral immune defects with granulomas 11.3 CTLA4 IL10 PTPN22
46 undifferentiated connective tissue disease 11.3
47 dermatomycosis 11.3 C4A C4B CD40LG
48 rapidly progressive glomerulonephritis 11.3
49 c3 deficiency 11.3
50 c1s deficiency 11.3
51 sneddon syndrome 11.3
52 lupus erythematosus tumidus 11.3
53 spondyloenchondrodysplasia 11.3
54 spindle cell hemangioma 11.3 FCGR2A FCGR3A IL10
55 moderately severe hemophilia b 11.3 CTLA4 FCGR2A IL10
56 chronic erythremia 11.3 C4A C4B CD40LG
57 ureteral lymphoma 11.2 C4A C4B CD40LG
58 congenital cataract-hypertrophic cardiomyopathy-mitochondrial myopathy syndrome 11.2 C4A C4B
59 oculo-cerebral dysplasia 11.2 CD40LG TLR5 TLR9
60 balkan hemorrhagic fever 11.2 CD40LG IL10
61 tick-borne encephalitis 11.2 CD40LG TREX1 TRIM21
62 common cold 11.2 CD40LG TLR5 TLR9
63 respiratory system disease 11.2 CD40LG IL10 SSB TRIM21
64 mesenchymal cell neoplasm 11.2 CD40LG IL10 PTPN22 TLR9
65 advanced sleep phase syndrome, familial, 1 11.2 CD40LG CTLA4 IL10 PDCD1 TLR9
66 goodpasture syndrome 11.2 C4A CD40LG CTLA4 IL10 STAT4 TLR9
67 hemochromatosis 11.2 C4A C4B
68 dieulafoy lesion 11.2 FCGR2A FCGR3A TLR9
69 geniculate ganglionitis 11.2 CR1 FCGR2A IL10 TLR9
70 dentinogenesis imperfecta 11.2 CD40LG FCGR2A IL10
71 tularemia 11.2 CD40LG IL10 TLR9
72 bartter disease 11.2 CD40LG CTLA4 PDCD1
73 adenoid squamous cell carcinoma 11.2 CD40LG IL10 TLR5 TLR9
74 gastric ulcer 11.2 CTLA4 IL10 TLR9
75 malignant hyperthermia 11.2 CTLA4 STAT4 TLR9
76 ostertagiasis 11.2 CD40LG IL10 TLR9
77 chanarin-dorfman syndrome 11.2 C4A DNASE1
78 pulmonary embolism 11.2 CD40LG FCGR2A IL10 TLR9
79 motor peripheral neuropathy 11.2 CD40LG IL10 TLR9
80 lacrimal system cancer 11.2 CD40LG CTLA4 IL10 TLR9 TRIM21
81 emphysema, congenital lobar 11.2 CD40LG FCGR2A FCGR3A
82 sublingual gland cancer 11.2 CD40LG IL10 TLR9
83 pelvic varices 11.2 CD40LG IL10 TLR9
84 vaginal spindle cell epithelioma 11.2 CD40LG IL10 SSB TLR9
85 clopidogrel resistance 11.2 CTLA4 PTPN22
86 congenital symblepharon 11.2 CD40LG CTLA4 IL10 TLR9
87 heart sarcoma 11.1 CD40LG IL10 TLR9
88 benign lymphoepithelial lesion of salivary gland 11.1 SSB TNFSF4 TRIM21
89 early congenital syphilis 11.1 CD40LG TLR9 TRIM21
90 vitamin k deficiency hemorrhagic disease 11.1 FCGR3A TRIM21
91 acute interstitial pneumonia 11.1 CD40LG IL10 TLR9
92 opportunistic bacterial infectious disease 11.1 CD40LG IL10 TLR9
93 acral lentiginous melanoma 11.1 CD40LG FCGR3A IL10
94 hypervitaminosis d 11.1 CD40LG IL10 TLR9
95 gout susceptibility 4 11.1 C4A C4B
96 acute chest syndrome 11.1 CD40LG IL10 TLR9
97 inner ear disease 11.1 CD40LG IL10 TLR9
98 hereditary amyloidosis 11.1 CD40LG FCGR2A
99 benign epilepsy with centrotemporal spikes 11.1 CD40LG TRIM21
100 actinic keratosis 11.1 C4A C4B CD40LG CTLA4 DNASE1 FCGR2B
101 mesangial proliferative glomerulonephritis 11.1
102 diamond-blackfan anemia 1 11.1 FCGR2A IL10 TLR9
103 diabetic angiopathy 11.1 CD40LG IL10
104 alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome 11.1 PTPN22 STAT4
105 neonatal autoimmune hemolytic anemia 11.0 C4A TRIM21
106 puerperal pulmonary embolism 11.0 C4A C4B
107 peroneal nerve paralysis 11.0 IL10 TLR9
108 tuberculum sellae meningioma 11.0 CD40LG IL10 TLR9
109 dumping syndrome 11.0 CD40LG IL10
110 glomerulopathy with fibronectin deposits 2 11.0
111 c2 deficiency 11.0
112 autoimmune inner ear disease 11.0
113 insulin-resistance type b 11.0
114 renal tubular acidosis, distal 11.0
115 autoimmune disease 6 11.0
116 chilblain lupus 2 11.0
117 c1q nephropathy 11.0
118 chilblain lupus 11.0
119 lupus - neurological sequelae 11.0
120 myasthenic syndrome, congenital, 7, presynaptic 10.9 CTLA4 PDCD1
121 facial nerve neoplasm 10.8 CD40LG TRIM21
122 arthritis 10.7
123 acute hemorrhagic encephalitis 10.7 CD40LG FCGR2B
124 antiphospholipid syndrome 10.6
125 antigen-peptide-transporter 2 deficiency 10.6 CTLA4 PTPN22
126 thrombosis 10.5
127 myelitis 10.5
128 endotheliitis 10.5
129 vasculitis 10.5
130 connective tissue disease 10.4
131 atherosclerosis 10.4
132 transverse myelitis 10.4
133 protein-losing enteropathy 10.4
134 purpura 10.4
135 retinitis 10.4
136 cerebritis 10.4
137 glomerulonephritis 10.3
138 hepatitis 10.3
139 thyroiditis 10.3
140 diffuse alveolar hemorrhage 10.3
141 discoid lupus erythematosus 10.3
142 intestinal pseudo-obstruction 10.3
143 thrombotic thrombocytopenic purpura 10.3
144 thrombocytopenia 10.3
145 lymphopenia 10.3
146 dermatomyositis 10.2
147 cardiac tamponade 10.2
148 tuberculosis 10.2
149 pneumonia 10.2
150 cutaneous lupus erythematosus 10.2
151 meningitis 10.2
152 aneurysm 10.2
153 osteonecrosis 10.2
154 rheumatic disease 10.2
155 cholecystitis 10.2
156 arthropathy 10.2
157 hemolytic anemia 10.2
158 nervous system disease 10.1
159 porphyria 10.1
160 myocardial infarction 10.1
161 autoimmune hepatitis 10.1
162 vascular disease 10.1
163 acalculous cholecystitis 10.1
164 complement deficiency 10.1
165 central nervous system disease 10.1
166 fasciitis 10.1
167 progressive multifocal leukoencephalopathy 10.1
168 panniculitis 10.1
169 pancreatitis 10.1
170 hyperprolactinemia 10.1
171 autoimmune hemolytic anemia 10.1
172 optic neuritis 10.1
173 neuropathy 10.1
174 dermatitis 10.1
175 herpes zoster 10.1
176 myocarditis 10.1
177 neuritis 10.1
178 pulmonary hypertension 10.1
179 renal tubular acidosis 10.1
180 retinal vasculitis 10.1
181 neutropenia 10.1
182 calcinosis 10.1
183 pemphigus 10.1
184 bronchiolitis 10.1
185 subacute cutaneous lupus erythematosus 10.1
186 calciphylaxis 10.1
187 leukemia 10.1
188 bronchiolitis obliterans 10.1
189 polymyositis 10.0
190 proliferative glomerulonephritis 10.0
191 heart disease 10.0
192 polyradiculoneuropathy 10.0
193 polyneuropathy 10.0
194 epidermolysis bullosa 10.0
195 intracranial hypertension 10.0
196 meningoencephalitis 10.0
197 pericarditis 10.0
198 granulomatous dermatitis 10.0
199 c4a deficiency 10.0
200 pernicious anemia 10.0
201 myositis 10.0
202 necrotizing fasciitis 10.0
203 porphyria cutanea tarda 10.0
204 hemophilia 10.0
205 systemic scleroderma 10.0
206 encephalopathy 10.0
207 headache 10.0
208 catastrophic antiphospholipid syndrome 10.0
209 nocardiosis 10.0
210 acute pancreatitis 10.0
211 thymoma 10.0
212 hydrocephalus 10.0
213 protein s deficiency 10.0
214 lymphadenitis 10.0
215 aortic aneurysm 10.0
216 internuclear ophthalmoplegia 10.0
217 influenza 10.0
218 hypothyroidism 10.0
219 retinal artery occlusion 10.0
220 endocarditis 10.0
221 strongyloidiasis 10.0
222 aseptic meningitis 10.0
223 myopathy 10.0
224 neuromyelitis optica 10.0
225 pericardial effusion 10.0
226 angioedema 10.0
227 central retinal artery occlusion 10.0
228 acquired hemophilia 10.0
229 cardiomyopathy 10.0
230 b-cell lymphomas 10.0
231 choroiditis 10.0
232 peritonitis 10.0
233 leprosy 10.0
234 cryoglobulinemia 10.0
235 miliary tuberculosis 10.0
236 hepatitis b 9.9
237 hypoparathyroidism 9.9
238 pneumatosis cystoides intestinalis 9.9
239 primary biliary cirrhosis 9.9
240 epilepsy 9.9
241 cryptococcosis 9.9
242 encephalitis 9.9
243 acute transverse myelitis 9.9
244 lupus erythematosus panniculitis 9.9
245 hypoprothrombinemia 9.9
246 cystitis 9.9
247 cerebral atrophy 9.9
248 hyperparathyroidism 9.9
249 artery disease 9.9
250 linear scleroderma 9.9
251 heart valve disease 9.9
252 septic arthritis 9.9
253 cytomegalovirus retinitis 9.9
254 aortitis 9.9
255 hellp syndrome 9.9
256 acute myocarditis 9.9
257 nodular regenerative hyperplasia 9.9
258 periodontitis 9.9
259 nephrotic syndrome 9.9
260 pancytopenia 9.9
261 demyelinating polyneuropathy 9.9
262 c1 inhibitor deficiency 9.9
263 anca-associated vasculitis 9.9
264 colitis 9.9
265 mononeuritis multiplex 9.9
266 ataxia 9.9
267 epidermodysplasia verruciformis 9.9
268 pulmonary sarcoidosis 9.9
269 celiac disease 9.9
270 acute myocardial infarction 9.9
271 common variable immunodeficiency 9.9
272 syphilis 9.9
273 pyomyositis 9.9
274 prolidase deficiency 9.9
275 silicosis 9.9
276 pleurisy 9.9
277 coronary aneurysm 9.9
278 kidney disease 9.9
279 lung disease 9.9
280 cytomegalovirus infection 9.9
281 alopecia 9.9
282 aspergillosis 9.9
283 eosinophilic fasciitis 9.9
284 salmonellosis 9.9
285 histoplasmosis 9.9
286 cranial nerve palsy 9.9
287 pyoderma 9.9
288 avascular necrosis of the femoral head 9.9
289 adult dermatomyositis 9.9
290 neuronitis 9.9
291 jaccoud's syndrome 9.9
292 spondylitis 9.9
293 aplastic anemia 9.9
294 chronic inflammatory demyelinating polyradiculoneuropathy 9.9
295 pyoderma gangrenosum 9.9
296 hemophagocytic lymphohistiocytosis 9.9
297 amenorrhea 9.9
298 tendinitis 9.8
299 erythema multiforme 9.8
300 interstitial cystitis 9.8
301 rheumatic fever 9.8
302 membranoproliferative glomerulonephritis 9.8
303 hypoaldosteronism 9.8
304 glucocorticoid resistance 9.8
305 alexithymia 9.8
306 breast cancer 9.8
307 chronic inflammatory demyelinating polyneuropathy 9.8
308 lambert-eaton myasthenic syndrome 9.8
309 hyporeninemic hypoaldosteronism 9.8
310 keratitis 9.8
311 acute lymphocytic leukemia 9.8
312 disseminated intravascular coagulation 9.8
313 c4b deficiency 9.8
314 chronic interstitial cystitis 9.8
315 hepatitis c 9.8
316 acquired immunodeficiency syndrome 9.8
317 retroperitoneal fibrosis 9.8
318 coronary artery disease 9.8
319 retinal vein occlusion 9.8
320 acute disseminated encephalomyelitis 9.8
321 pemphigus erythematosus 9.8
322 kawasaki disease 9.8
323 lepromatous leprosy 9.8
324 relapsing polychondritis 9.8
325 mycobacterium kansasii 9.8
326 focal segmental glomerulosclerosis 9.8
327 tuberculoid leprosy 9.8
328 portal vein thrombosis 9.8
329 candidiasis 9.8
330 parotitis 9.8
331 urticaria 9.8
332 bullous pemphigoid 9.8
333 adult-onset still's disease 9.8
334 zygomycosis 9.8
335 hydronephrosis 9.8
336 cerebellar ataxia 9.8
337 lysinuric protein intolerance 9.8
338 hematopoietic stem cell transplantation 9.8
339 osteoarthritis 9.8
340 cellulitis 9.8
341 cerebrovascular disease 9.8
342 communicating hydrocephalus 9.8
343 heparin-induced thrombocytopenia 9.8
344 refractory anemia 9.8
345 asthma 9.8
346 sensorineural hearing loss 9.8
347 respiratory failure 9.8
348 uveitis 9.8
349 pyuria 9.8
350 herpes simplex 9.8
351 acquired von willebrand syndrome 9.8
352 hiv-1 9.8
353 pemphigus foliaceus 9.8
354 arteriosclerosis 9.8
355 meige syndrome 9.8
356 central nervous system vasculitis 9.8
357 hashimoto thyroiditis 9.7
358 autoimmune lymphoproliferative syndrome 9.7
359 mastitis 9.7
360 central retinal vein occlusion 9.7
361 sagittal sinus thrombosis 9.7
362 reactive arthritis 9.7
363 paralytic ileus 9.7
364 t cell deficiency 9.7
365 renovascular hypertension 9.7
366 pericardial mesothelioma 9.7
367 lichen planus 9.7
368 hypocomplementemic urticarial vasculitis 9.7
369 peripartum cardiomyopathy 9.7
370 paraneoplastic pemphigus 9.7
371 pulmonary fibrosis 9.7
372 spondyloarthropathy 9.7
373 retinal vascular disease 9.7
374 eosinophilic gastroenteritis 9.7
375 coronary artery aneurysm 9.7
376 collagenous colitis 9.7
377 kluver-bucy syndrome 9.7
378 bursitis 9.7
379 localized scleroderma 9.7
380 autonomic dysfunction 9.7
381 multiple myeloma 9.7
382 osteomyelitis 9.7
383 pulmonary hemosiderosis 9.7
384 tolosa-hunt syndrome 9.7
385 splenic abscess 9.7
386 axonal neuropathy 9.7
387 kikuchi disease 9.7
388 psoriatic arthritis 9.7
389 crohn's disease 9.7
390 purpura fulminans 9.7
391 hemosiderosis 9.7
392 guillain-barre syndrome 9.7
393 splenic infarction 9.7
394 interstitial lung disease 9.7
395 hyperthyroidism 9.7
396 scotoma 9.7
397 hypereosinophilic syndrome 9.7
398 mycobacterium fortuitum 9.7
399 tetanus 9.7
400 pulmonary alveolar proteinosis 9.7
401 miller fisher syndrome 9.7
402 hereditary angioedema 9.7
403 carotid artery dissection 9.7
404 tenosynovitis 9.7
405 hypoglycemia 9.7
406 reversible cerebral vasoconstriction syndrome 9.7
407 inclusion body myositis 9.7
408 skin disease 9.7
409 lymphoproliferative syndrome 9.7
410 cervicitis 9.7
411 proctitis 9.7
412 exophthalmos 9.7
413 rosai-dorfman disease 9.7
414 cardiogenic shock 9.7
415 aortic atherosclerosis 9.7
416 marginal zone b-cell lymphoma 9.7
417 dysgammaglobulinemia 9.7
418 neurogenic bladder 9.7
419 chronic mucocutaneous candidiasis 9.7
420 papilloma 9.7
421 acanthosis nigricans 9.7
422 periodontal disease 9.7
423 dermatitis herpetiformis 9.7
424 gigantism 9.7
425 pseudo-meigs syndrome 9.7
426 budd-chiari syndrome 9.7
427 temporal lobe epilepsy 9.7
428 squamous cell carcinoma 9.7
429 histiocytosis 9.7
430 shwartzman phenomenon 9.7
431 adenoma 9.7
432 epiglottitis 9.7
433 peripheral artery disease 9.7
434 cryptococcal meningitis 9.7
435 synovitis 9.7
436 polyradiculopathy 9.7
437 cerebral lymphoma 9.7
438 cytophagic histiocytic panniculitis 9.7
439 hemoglobinuria 9.7
440 anterior spinal artery syndrome 9.7
441 lymphocytic hypophysitis 9.7
442 henoch-schoenlein purpura 9.7
443 cushing's syndrome 9.7
444 normal pressure hydrocephalus 9.7
445 polyarteritis nodosa 9.7
446 acquired hemophilia a 9.7
447 sudden sensorineural hearing loss 9.7
448 hemophilia a 9.7
449 malignant atrophic papulosis 9.7
450 invasive aspergillosis 9.7
451 inflammatory myofibroblastic tumor 9.7
452 graves' disease 9.7
453 tinea capitis 9.7
454 deep keratitis 9.7
455 superior vena cava syndrome 9.7
456 reflex sympathetic dystrophy 9.7
457 paroxysmal nocturnal hemoglobinuria 9.7
458 gastroenteritis 9.7
459 chronic active epstein-barr virus infection 9.7
460 malakoplakia 9.7
461 oral lichen planus 9.7
462 peripheral vascular disease 9.7
463 hemolytic-uremic syndrome 9.7
464 gout 9.7
465 neuroleptic malignant syndrome 9.7
466 diffuse scleroderma 9.7
467 ischemia 9.7
468 scabies 9.7
469 malignant histiocytosis 9.7
470 amaurosis fugax 9.7
471 chronic graft versus host disease 9.7
472 hyper ige syndrome 9.7
473 papular mucinosis 9.7
474 moyamoya disease 9.6
475 cerebral hemorrhage 9.6
476 pemphigus vulgaris 9.6
477 cysticercosis 9.6
478 hemopericardium 9.6
479 ecthyma 9.6
480 pyloric stenosis 9.6
481 herpes gestationis 9.6
482 status epilepticus 9.6
483 hydranencephaly 9.6
484 blepharospasm 9.6
485 subacute thyroiditis 9.6
486 dacryoadenitis 9.6
487 median arcuate ligament syndrome 9.6
488 cold agglutinin disease 9.6
489 microscopic polyangiitis 9.6
490 pasteurella multocida infection 9.6
491 t-cell/histiocyte rich large b cell lymphoma 9.6
492 stevens-johnson syndrome/toxic epidermal necrolysis 9.6
493 syncope 9.6
494 recurrent acute pancreatitis 9.6
495 osteoporotic fracture 9.6
496 schizophrenia 9.6
497 c6 deficiency 9.6
498 chronic granulomatous disease 9.6
499 swine influenza 9.6
500 venous insufficiency 9.6
501 paragonimiasis 9.6
502 esophagitis 9.6
503 paracoccidioidomycosis 9.6
504 typhoid fever 9.6
505 splenic artery aneurysm 9.6
506 chorea gravidarum 9.6
507 teratocarcinoma 9.6
508 gastritis 9.6
509 intracranial hypotension 9.6
510 sleep disorder 9.6
511 intussusception 9.6
512 subacute delirium 9.6
513 dextrocardia 9.6
514 villonodular synovitis 9.6
515 angioimmunoblastic t-cell lymphoma 9.6
516 congenital cytomegalovirus 9.6
517 mollaret meningitis 9.6
518 tetrasomy x 9.6
519 osteoporosis 9.6
520 anorexia nervosa 9.6
521 cardiac conduction defect 9.6
522 acne 9.6
523 intraocular lymphoma 9.6
524 dry eye syndrome 9.6
525 portal hypertension 9.6
526 autonomic neuropathy 9.6
527 nephrocalcinosis 9.6
528 poems syndrome 9.6
529 reye syndrome 9.6
530 pulmonary tuberculosis 9.6
531 teratoma 9.6
532 erythromelalgia 9.6
533 follicular mucinosis 9.6
534 anton's syndrome 9.6
535 multicentric castleman disease 9.6
536 thrombasthenia 9.6
537 undifferentiated embryonal sarcoma of the liver 9.6
538 factor xii deficiency 9.6
539 chronic myelomonocytic leukemia 9.6
540 hypophosphatemia 9.6
541 neuroretinitis 9.6
542 hypertensive retinopathy 9.6
543 hypercementosis 9.6
544 autoimmune polyendocrine syndrome 9.6
545 central nervous system tuberculosis 9.6
546 impotence 9.6
547 brachial plexus neuropathy 9.6
548 secondary syphilis 9.6
549 pulmonary venoocclusive disease 9.6
550 nodular episcleritis 9.6
551 hyperhomocysteinemia 9.6
552 periostitis 9.6
553 embryonal sarcoma 9.6
554 mycetoma 9.6
555 thymic hyperplasia 9.6
556 colorectal cancer 9.6
557 liver cirrhosis 9.6
558 inflammatory bowel disease 9.6
559 atrial fibrillation 9.6
560 methemoglobinemia 9.6
561 cat-scratch disease 9.6
562 bipolar i disorder 9.6
563 papilledema 9.6
564 hyperglobulinemic purpura 9.6
565 hermansky-pudlak syndrome 9.6
566 actinomycosis 9.6
567 priapism 9.6
568 toxoplasmosis 9.6
569 autoimmune myocarditis 9.6
570 eosinophilic granulomatosis with polyangiitis 9.6
571 mycobacterium chelonae 9.6
572 central cord syndrome 9.6
573 vulvar intraepithelial neoplasia 9.6
574 hypertriglyceridemia 9.6
575 adult respiratory distress syndrome 9.6
576 liver disease 9.6
577 extrapulmonary tuberculosis 9.6
578 malignant hypertension 9.6
579 lemierre's syndrome 9.6
580 cicatricial pemphigoid 9.6
581 scleritis 9.6
582 neonatal myasthenia gravis 9.6
583 prostatitis 9.6
584 hyperuricemia 9.6
585 anovulation 9.6
586 subacute glomerulonephritis 9.6
587 anal squamous cell carcinoma 9.6
588 babesiosis 9.6
589 bone marrow necrosis 9.6
590 fibrillary glomerulonephritis 9.6
591 large granular lymphocyte leukemia 9.6
592 retroperitoneal liposarcoma 9.6
593 trochleitis 9.6
594 obesity 9.6
595 membranous nephropathy 9.6
596 juvenile myelomonocytic leukemia 9.6
597 adult t-cell leukemia 9.6
598 diffuse large b-cell lymphoma 9.6
599 lymphomatoid granulomatosis 9.6
600 abdominal tuberculosis 9.6
601 erythema elevatum diutinum 9.6
602 palindromic rheumatism 9.6
603 tuberous sclerosis 9.6
604 phaeohyphomycosis 9.6
605 ichthyosis 9.6
606 hypogonadism 9.6
607 gingivitis 9.6
608 porokeratosis 9.6
609 echolalia 9.6
610 hemarthrosis 9.6
611 psoriasis 9.6
612 bowen's disease 9.6
613 germ cells tumors 9.6
614 lichen sclerosus 9.6
615 tuberculous meningitis 9.6
616 acquired cutis laxa 9.6
617 hepatosplenic t-cell lymphoma 9.6
618 human herpesvirus 8 9.6
619 mannosidosis 9.6
620 t-cell large granular lymphocyte leukemia 9.6
621 transsexualism 9.6
622 epidural abscess 9.6
623 chagas disease 9.6
624 toxic shock syndrome 9.6
625 retinal vascular occlusion 9.6
626 liposarcoma 9.6
627 hypertrichosis 9.6
628 cavernous hemangioma 9.6
629 diffuse pulmonary fibrosis 9.6
630 carotid artery occlusion 9.6
631 impetigo 9.6
632 dermatophytosis 9.6
633 renal tuberculosis 9.6
634 bowenoid papulosis 9.6
635 giant cell myocarditis 9.6
636 limbic encephalitis 9.6
637 mycobacterium marinum 9.6
638 ulcerative proctitis 9.6
639 dysautonomia 9.6
640 bacteremia 9.6
641 cystic fibrosis 9.6
642 rheumatic heart disease 9.6
643 intracranial aneurysm 9.6
644 subdural empyema 9.6
645 endomyocardial fibrosis 9.6
646 posterior scleritis 9.6
647 obstructive hydrocephalus 9.6
648 gerstmann syndrome 9.6
649 retinal disease 9.6
650 adrenal adenoma 9.6
651 lipodystrophy 9.6
652 evans' syndrome 9.6
653 iridocyclitis 9.6
654 diastolic heart failure 9.6
655 sickle cell disease 9.6
656 linear iga disease 9.6
657 mycobacterium xenopi 9.6
658 serpiginous choroiditis 9.6
659 solar urticaria 9.6
660 takayasu arteritis 9.6
661 pulmonary edema 9.6
662 lyme disease 9.6
663 eumycotic mycetoma 9.6
664 hepatic infarction 9.6
665 intestinal perforation 9.6
666 pigmented villonodular synovitis 9.6
667 cutis laxa 9.6
668 aortic valve insufficiency 9.6
669 sideroblastic anemia 9.6
670 irritable bowel syndrome 9.6
671 trichorhinophalangeal syndrome 9.6
672 cardiac rupture 9.6
673 gigantomastia 9.6
674 necrotizing autoimmune myopathy 9.6
675 spastic paraparesis 9.6
676 wells syndrome 9.6
677 extrapontine myelinolysis 9.6
678 tafro syndrome 9.6
679 acute adrenal insufficiency 9.6
680 stiff-person syndrome 9.6
681 asbestosis 9.6
682 q fever 9.6
683 pseudoretinitis pigmentosa 9.6
684 addison's disease 9.6
685 mitral valve stenosis 9.6
686 thrombocytosis 9.6
687 lipomatosis 9.6
688 thrombophlebitis 9.6
689 arteriosclerosis obliterans 9.6
690 subcorneal pustular dermatosis 9.6
691 choledochal cyst 9.6
692 diabetes insipidus 9.6
693 tuberculous peritonitis 9.6
694 acquired generalized lipodystrophy 9.6
695 castleman disease 9.6
696 granulocytopenia 9.6
697 splenomegaly 9.6
698 transient neonatal myasthenia gravis 9.6
699 alopecia universalis 9.6
700 wiskott-aldrich syndrome 9.6
701 mycosis fungoides 9.6
702 hemangioma 9.6
703 ulcerative colitis 9.6
704 hemorrhagic cystitis 9.6
705 chronic meningitis 9.6
706 pyelonephritis 9.6
707 multicentric reticulohistiocytosis 9.6
708 superficial keratitis 9.6
709 hypermobility syndrome 9.6
710 oral candidiasis 9.6
711 chromoblastomycosis 9.6
712 cheilitis 9.6
713 granulomatous hepatitis 9.6
714 nemaline myopathy 9.6
715 laryngitis 9.6
716 mediastinitis 9.6
717 liver lymphoma 9.6
718 blepharitis 9.6
719 hypersensitivity vasculitis 9.6
720 granulomatous lobular mastitis 9.6
721 neuromyelitis optica spectrum disorder 9.6
722 hypertonia 9.6
723 juvenile myasthenia gravis 9.6
724 melioidosis 9.6
725 trichorhinophalangeal syndrome, type i 9.6
726 fabry disease 9.6
727 trigeminal neuralgia 9.6
728 chikungunya 9.6
729 villous adenoma 9.6
730 meningococcal meningitis 9.6
731 hypopyon 9.6
732 xanthogranulomatous pyelonephritis 9.6
733 myopia 9.6
734 sclerosing cholangitis 9.6
735 pharyngitis 9.6
736 tropical spastic paraparesis 9.6
737 aortic disease 9.6
738 inferior myocardial infarction 9.6
739 leishmaniasis 9.6
740 central serous chorioretinopathy 9.6
741 haemophilus influenzae 9.6
742 lymphocytic vasculitis 9.6
743 cardiovascular disease risk factor ) 9.6
744 atlantoaxial subluxation 9.6
745 ovarian hyperstimulation syndrome 9.6
746 lymphangioleiomyomatosis 9.6
747 endometrial cancer 9.6
748 bipolar disorder 9.6
749 mucositis 9.6
750 sarcoma 9.6
751 diphtheria 9.6
752 cortical blindness 9.6
753 crescentic glomerulonephritis 9.6
754 necrotizing ulcerative gingivitis 9.6
755 suppurative thyroiditis 9.6
756 turner syndrome 9.6
757 loeffler endocarditis 9.6
758 brown-sequard syndrome 9.6
759 bilateral breast cancer 9.6
760 amyloidosis 9.6
761 cholangitis 9.6
762 acquired hypoprothrombinemia 9.6
763 chorea minor 9.6
764 nontuberculous mycobacterial lung disease 9.6
765 myoclonus 9.6
766 systemic polyarteritis nodosa 9.6
767 trichomegaly 9.6
768 prader-willi syndrome 9.6
769 autoimmune polyendocrine syndrome type 1 9.6
770 infective endocarditis 9.6
771 glucose intolerance 9.6
772 tracheal stenosis 9.6
773 restrictive cardiomyopathy 9.6
774 mitral valve disease 9.6
775 compartment syndrome 9.6
776 peliosis hepatis 9.6
777 bacterial meningitis 9.6
778 alopecia areata 9.6
779 homocysteinemia 9.6
780 synovial chondromatosis 9.6
781 paraneoplastic syndromes 9.6
782 spontaneous intracranial hypotension 9.6
783 intravascular large b-cell lymphoma 9.6
784 dubin-johnson syndrome 9.6
785 pseudoxanthoma elasticum 9.6
786 burns 9.6
787 syphilitic meningitis 9.6
788 enophthalmos 9.6
789 constrictive pericarditis 9.6
790 mononeuropathy 9.6
791 superior mesenteric artery syndrome 9.6
792 large cell carcinoma 9.6
793 t-cell leukemia 9.6
794 visceral leishmaniasis 9.6
795 meningococcal infection 9.6
796 systemic onset juvenile idiopathic arthritis 9.6
797 spasticity 9.6
798 acute macular neuroretinopathy 9.6
799 ischemic retinopathy 9.6

Comorbidity relations with Systemic Lupus Erythematosus via Phenotypic Disease Network (PDN): (showing 20, show less)


Acute Cystitis Chronic Kidney Failure
Chronic Myocardial Ischemia Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
Heart Disease Hypersensitivity Vasculitis
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease Neutropenia
Osteoporosis Postinflammatory Pulmonary Fibrosis
Raynaud Disease Rheumatoid Arthritis
Sjogren's Syndrome Systemic Scleroderma

Graphical network of the top 20 diseases related to Systemic Lupus Erythematosus:



Diseases related to Systemic Lupus Erythematosus

Symptoms & Phenotypes for Systemic Lupus Erythematosus

Symptoms via clinical synopsis from OMIM:

54

Neurologic- Central Nervous System:
seizures
psychosis

Skin Nails & Hair- Skin:
photosensitivity
erythematous malar rash
discoid rash

Respiratory- Lung:
pleuritis

Skeletal- Limbs:
arthritis

Laboratory- Abnormalities:
antiphospholipid antibody
anti dsdna antibody
serum antinuclear antibody

Hematology:
thrombocytopenia
leukopenia
hemolytic anemia

Cardiovascular- Heart:
pericarditis

Genitourinary- Kidneys:
nephritis

Immunology:
systemic lupus erythematosus


Clinical features from OMIM:

152700

Human phenotypes related to Systemic Lupus Erythematosus:

32 (showing 13, show less)
id Description HPO Frequency HPO Source Accession
1 seizures 32 HP:0001250
2 thrombocytopenia 32 HP:0001873
3 leukopenia 32 HP:0001882
4 pericarditis 32 HP:0001701
5 pleuritis 32 HP:0002102
6 nephritis 32 HP:0000123
7 arthritis 32 HP:0001369
8 psychosis 32 HP:0000709
9 hemolytic anemia 32 HP:0001878
10 systemic lupus erythematosus 32 HP:0002725
11 cutaneous photosensitivity 32 HP:0000992
12 antinuclear antibody positivity 32 HP:0003493
13 antiphospholipid antibody positivity 32 HP:0003613

UMLS symptoms related to Systemic Lupus Erythematosus:


cyanosis, exanthema, icterus, pruritus, lupus-like rash, seizures

MGI Mouse Phenotypes related to Systemic Lupus Erythematosus:

44 (showing 10, show less)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.31 C4B CD40LG CTLA4 DNASE1 FCGR2A FCGR2B
2 immune system MP:0005387 10.22 TLR5 TLR9 TNFSF4 TREX1 TRIM21 C4B
3 homeostasis/metabolism MP:0005376 10.21 C4B CD40LG CTLA4 DNASE1 FCGR2B IL10
4 cardiovascular system MP:0005385 10.18 C4B CD40LG CTLA4 FCGR2B IL10 PDCD1
5 endocrine/exocrine gland MP:0005379 10.09 CD40LG CTLA4 FCGR2B IL10 PDCD1 PTPN22
6 digestive/alimentary MP:0005381 10.06 PTPN22 TLR5 TLR9 TREX1 C4B CTLA4
7 mortality/aging MP:0010768 10.03 TREX1 C4B CD40LG CTLA4 DNASE1 FCGR2A
8 liver/biliary system MP:0005370 9.86 C4B CTLA4 FCGR2B IL10 PDCD1 PTPN22
9 renal/urinary system MP:0005367 9.65 C4B CD40LG DNASE1 FCGR2B PDCD1 PTPN22
10 respiratory system MP:0005388 9.17 CTLA4 FCGR2B IL10 PDCD1 PTPN22 TLR5

Drugs & Therapeutics for Systemic Lupus Erythematosus

Drugs for Systemic Lupus Erythematosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 364, show less)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 4,Phase 1,Early Phase 1 79902-63-9 54454
2
Everolimus Approved Phase 4,Phase 2 159351-69-6 6442177
3
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
4
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
5
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
6
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
7
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
8
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 53-03-2 5865
9
Sirolimus Approved, Investigational Phase 4,Phase 2 53123-88-9 5284616 6436030 46835353
10
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 104987-11-3 445643 439492
11
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 50-18-0, 6055-19-2 2907
12
Hydroxychloroquine Approved Phase 4,Phase 3,Phase 1,Phase 2 118-42-3 3652
13
belimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 356547-88-1 5957 10451420
14
Pioglitazone Approved, Investigational Phase 4,Phase 1,Phase 2 111025-46-8 4829
15
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
16
Azathioprine Approved Phase 4,Phase 3,Phase 2,Phase 1 446-86-6 2265
17
Cilostazol Approved Phase 4 73963-72-1 2754
18
Lenalidomide Approved Phase 4 191732-72-6 216326
19
Metformin Approved Phase 4 657-24-9 14219 4091
20
Sulfamethoxazole Approved Phase 4 723-46-6 5329
21
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
22
Thioguanine Approved Phase 4 154-42-7 2723601
23
Vincristine Approved, Investigational Phase 4 2068-78-2, 57-22-7 5978
24
Calcitriol Approved, Nutraceutical Phase 4,Phase 2 32222-06-3 134070 5280453
25
Alfacalcidol Approved, Nutraceutical Phase 4 41294-56-8 5282181
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
27
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 143 6006
28
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 1 50-14-6 5280793
29
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 1406-16-2
30 Anticholesteremic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
31 Antimetabolites Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
32 Calcium, Dietary Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
33 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
34 Hypolipidemic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
35 Lipid Regulating Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
36 Rosuvastatin Calcium Phase 4,Phase 2,Phase 1 147098-20-2
37 Vaccines Phase 4,Phase 2,Phase 3,Phase 1
38 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
39 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
40 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1
41 Antifungal Agents Phase 4,Phase 2,Phase 1
42 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
44 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
45 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1
46 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
47 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
48 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
49 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
50 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
51 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
52 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
53 Methylprednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1
54 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2,Phase 1
55 Neuroprotective Agents Phase 4,Phase 3,Phase 2,Phase 1
56 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
57 Prednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1
58 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2,Phase 1
59 Prednisolone phosphate Phase 4,Phase 3,Phase 2,Phase 1
60 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
61 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
62 Antibodies Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
63 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
64 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3,Phase 1
65 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1
66 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1
67 Vitamins Phase 4,Phase 3,Phase 2,Phase 1
68 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
69 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1
70 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1
71 Estrogens Phase 4,Phase 3,Phase 2,Phase 1
72 Atorvastatin Calcium Phase 4,Phase 2,Phase 3,Phase 1 134523-03-8
73 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1
74 Autoantibodies Phase 4,Phase 2,Phase 3,Phase 1
75 Vasoconstrictor Agents Phase 4,Phase 2
76 Antimalarials Phase 4,Phase 3,Phase 1,Phase 2
77 Antiparasitic Agents Phase 4,Phase 3,Phase 1,Phase 2
78 Antiprotozoal Agents Phase 4,Phase 3,Phase 1,Phase 2
79 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 2,Phase 3
80 Diphosphonates Phase 4
81 Hydroxycholecalciferols Phase 4
82 Ibandronic acid Phase 4
83 Hypoglycemic Agents Phase 4,Phase 1,Phase 2
84 Antipyretics Phase 4,Phase 2,Phase 3,Phase 1
85 Cyclooxygenase Inhibitors Phase 4,Phase 1
86 Fibrinolytic Agents Phase 4,Phase 1,Phase 2
87 Platelet Aggregation Inhibitors Phase 4,Phase 1,Phase 2
88 Adrenocorticotropic Hormone Phase 4
89 beta-endorphin Phase 4
90 Melanocyte-Stimulating Hormones Phase 4
91 Estrogens, Conjugated (USP) Phase 4,Phase 3
92 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1
93 Anti-Asthmatic Agents Phase 4,Phase 1
94 Bronchodilator Agents Phase 4
95 Phosphodiesterase 3 Inhibitors Phase 4
96 Phosphodiesterase Inhibitors Phase 4,Phase 1,Phase 2
97 Respiratory System Agents Phase 4,Phase 2,Phase 3,Phase 1
98 Vasodilator Agents Phase 4,Phase 2
99 Angiogenesis Inhibitors Phase 4,Phase 2
100 Angiogenesis Modulating Agents Phase 4,Phase 2
101 Folic Acid Antagonists Phase 4,Phase 3,Phase 2
102 Vitamin B Complex Phase 4,Phase 3,Phase 2
103 6-Mercaptopurine Phase 4,Phase 2
104 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
105 Antimitotic Agents Phase 4,Phase 2
106 Antineoplastic Agents, Phytogenic Phase 4,Phase 2
107 Ergocalciferols Phase 4,Phase 2,Phase 1
108 Antidepressive Agents Phase 4
109 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1
110 Neurotransmitter Uptake Inhibitors Phase 4
111 Psychotropic Drugs Phase 4
112
Serotonin Phase 4 50-67-9 5202
113 Serotonin Agents Phase 4
114 Serotonin Uptake Inhibitors Phase 4
115 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 1,Phase 2
116 Renal Agents Phase 4
117 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
118 Omega 3 Fatty Acid Nutraceutical Phase 4,Phase 2
119 Folate Nutraceutical Phase 4,Phase 3,Phase 2
120 Vitamin B9 Nutraceutical Phase 4,Phase 3,Phase 2
121 Calciferol Nutraceutical Phase 4,Phase 2,Phase 1
122 Vitamin D2 Nutraceutical Phase 4,Phase 2,Phase 1
123
Benzocaine Approved Phase 3,Phase 1 1994-09-7, 94-09-7 2337
124
Methotrexate Approved Phase 3,Phase 1,Phase 2 1959-05-2, 59-05-2 126941
125
Acetaminophen Approved Phase 2, Phase 3, Phase 1 103-90-2 1983
126
Diphenhydramine Approved Phase 2, Phase 3, Phase 1 58-73-1, 147-24-0 3100
127
Histamine Approved, Investigational Phase 2, Phase 3 75614-87-8, 51-45-6 774
128
Promethazine Approved Phase 2, Phase 3, Phase 1 60-87-7 4927