MCID: SYS001
MIFTS: 86

Systemic Lupus Erythematosus

Categories: Genetic diseases, Rare diseases, Skin diseases, Bone diseases, Nephrological diseases, Immune diseases

Aliases & Classifications for Systemic Lupus Erythematosus

MalaCards integrated aliases for Systemic Lupus Erythematosus:

Name: Systemic Lupus Erythematosus 53 37 12 72 24 50 71 36 28 3 14
Lupus Nephritis 53 12 49 36 51 41 14 69
Lupus Erythematosus, Systemic 12 41 69
Sle 53 24 71
Disseminated Lupus Erythematosus 12 24
Libman-Sacks Disease 24 69
Systemic Lupus Erythematosus, Susceptibility to 53
Systemic Lupus Erythematosus Susceptibility to 53
Sle - Lupus Erythematosus, Systemic 12
Lupus Nephritis, Susceptibility to 53
Lupus Erythematosus Systemic 51
Lupus Erythematosus, Discoid 69
Lupus Erythematosus 69
Lupus Vulgaris 69
Le Syndrome 24
Lupus 24

Characteristics:

OMIM:

53
Inheritance:
autosomal dominant

Miscellaneous:
complement deficiency (e.g. c2 and c4 null alleles) are susceptible to developing sle
association between hla class ii alleles and presence of autoantibodies
onset between ages 16-55
female to male ratio 8-13:1


HPO:

31
systemic lupus erythematosus:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Systemic Lupus Erythematosus

NINDS : 50 Lupus (also called systemic lupus erythematosus) is a disorder of the immune system. Normally, the immune system protects the body against invading infections and cancers. In lupus, the immune system is over-active and produces increased amounts of abnormal antibodies that attack the body's tissues and organs. Lupus can affect many parts of the body, including the joints, skin, kidneys, lungs, heart, nervous system, and blood vessels. The signs and symptoms of lupus differ from person to person; the disease can range from mild to life threatening. Initial symptoms of lupus may begin with a fever, vascular headaches, epilepsy, or psychoses. A striking feature of lupus is a butterfly shaped rash over the cheeks. In addition to headache, lupus can cause other neurological disorders, such as mild cognitive dysfunction, organic brain syndrome, peripheral neuropathies, sensory neuropathy, psychological problems (including personality changes, paranoia, mania, and schizophrenia), seizures, transverse myelitis, and paralysis and stroke.

MalaCards based summary : Systemic Lupus Erythematosus, also known as lupus nephritis, is related to systemic lupus erythematosus 16 and pediatric systemic lupus erythematosus, and has symptoms including seizures, arthritis and hemolytic anemia. An important gene associated with Systemic Lupus Erythematosus is PTPN22 (Protein Tyrosine Phosphatase, Non-Receptor Type 22), and among its related pathways/superpathways are Systemic lupus erythematosus and Innate Immune System. The drugs Simvastatin and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include Umbilical Cord, t cells and skin, and related phenotypes are hematopoietic system and immune system

OMIM : 53 Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. Tissue deposition of antibodies or immune complexes induces inflammation and subsequent injury of multiple organs and finally results in clinical manifestations of SLE, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and arthritis. Evidence strongly suggests the involvement of genetic components in SLE susceptibility (summary by Oishi et al., 2008). (152700)

UniProtKB/Swiss-Prot : 71 Systemic lupus erythematosus: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

NIH Rare Diseases : 49 Lupus nephritis is a kidney disorder that is a complication of systemic lupus erythematous (SLE), commonly known as lupus. The symptoms of lupus nephritis include blood in the urine, a foamy appearance to the urine, high blood pressure, and swelling in any part of the body. This condition typically occurs in people aged 20 to 40 years. Treatment may involve medications to suppress the immune system, dialysis, or a kidney transplant. Visit our Web page on lupus for more information and resources. Last updated: 11/24/2010

CDC : 3 Lupus occurs when an unknown trigger causes a person’s own immune system to attack their tissues, damaging the tissues and producing widespread inflammation. There is no known cause or cure for lupus; however, treatments are available.

Genetics Home Reference : 24 Systemic lupus erythematosus (SLE) is a chronic disease that causes inflammation in connective tissues, such as cartilage and the lining of blood vessels, which provide strength and flexibility to structures throughout the body. The signs and symptoms of SLE vary among affected individuals, and can involve many organs and systems, including the skin, joints, kidneys, lungs, central nervous system, and blood-forming (hematopoietic) system. SLE is one of a large group of conditions called autoimmune disorders that occur when the immune system attacks the body's own tissues and organs.

Disease Ontology : 12 A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart.

Wikipedia : 72 Systemic lupus erythematosus (SLE), also known simply as lupus, is an autoimmune disease in which the... more...

Related Diseases for Systemic Lupus Erythematosus

Diseases in the Lupus Erythematosus family:

Systemic Lupus Erythematosus Systemic Lupus Erythematosus 15
Systemic Lupus Erythematosus 1 Systemic Lupus Erythematosus 2
Systemic Lupus Erythematosus 3 Systemic Lupus Erythematosus 4
Systemic Lupus Erythematosus 5 Systemic Lupus Erythematosus 6
Systemic Lupus Erythematosus 7 Systemic Lupus Erythematosus 8
Systemic Lupus Erythematosus 9 Systemic Lupus Erythematosus 10
Systemic Lupus Erythematosus 11 Systemic Lupus Erythematosus 12
Systemic Lupus Erythematosus 13 Systemic Lupus Erythematosus 14
Systemic Lupus Erythematosus 16

Diseases related to Systemic Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 896, show less)
# Related Disease Score Top Affiliating Genes
1 systemic lupus erythematosus 16 35.4 C4A DNASE1
2 pediatric systemic lupus erythematosus 35.0 C4A C4B PTPN22
3 systemic lupus erythematosus 1 35.0 ENG TLR5 TREX1
4 lupus erythematosus 35.0 BANK1 C4A C4B CTLA4 DNASE1 ENG
5 vitiligo-associated multiple autoimmune disease susceptibility 1 34.5 C4B CTLA4 PTPN22
6 neonatal lupus erythematosus 34.3 C4A TRIM21
7 autoimmune disease 31.9 CTLA4 FCGR2A FCGR2B FCGR3A PDCD1 PTPN22
8 hypersensitivity reaction type iii disease 30.5 C4A C4B
9 systemic lupus erythematosus 2 12.6
10 systemic lupus erythematosus 9 12.5
11 systemic lupus erythematosus 10 12.5
12 systemic lupus erythematosus 6 12.5
13 systemic lupus erythematosus 11 12.5
14 systemic lupus erythematosus with hemolytic anemia 1 12.4
15 systemic lupus erythematosus 3 12.4
16 systemic lupus erythematosus with nephritis 1 12.4
17 systemic lupus erythematosus with nephritis 2 12.4
18 systemic lupus erythematosus with nephritis 3 12.4
19 systemic lupus erythematosus 4 12.4
20 systemic lupus erythematosus 5 12.4
21 systemic lupus erythematosus 12 12.4
22 neonatal systemic lupus erythematosus 12.3
23 systemic lupus erythematosus 15 12.2
24 systemic lupus erythematosus 7 12.2
25 systemic lupus erythematosus 8 12.2
26 systemic lupus erythematosus 13 12.2
27 systemic lupus erythematosus 14 12.2
28 c1q deficiency 11.7
29 mixed connective tissue disease 11.7
30 drug-induced lupus erythematosus 11.4
31 hypogonadotropic hypogonadism 11.4
32 pure red-cell aplasia 11.4
33 cutaneous lupus erythematosus 11.4
34 sjogren syndrome 11.4
35 macrophage activation syndrome 11.4
36 epidermolysis bullosa acquisita 11.4
37 renal tubular acidosis, distal 11.4
38 undifferentiated connective tissue disease 11.4
39 sneddon syndrome 11.4
40 complement component 3 deficiency, autosomal recessive 11.4
41 complement component c1s deficiency 11.4
42 rapidly progressive glomerulonephritis 11.4
43 lupus erythematosus tumidus 11.4
44 spondyloenchondrodysplasia 11.4
45 mesangial proliferative glomerulonephritis 11.2
46 complement component 2 deficiency 11.1
47 pseudo-torch syndrome 1 11.1
48 glomerulopathy with fibronectin deposits 2 11.1
49 chilblain lupus 1 11.1
50 autoimmune disease 6 11.1
51 chilblain lupus 2 11.1
52 autoimmune inner ear disease 11.1
53 c1q nephropathy 11.1
54 insulin-resistance type b 11.1
55 singleton-merten syndrome 11.1
56 lupus - neurological sequelae 11.1
57 multifocal motor neuropathy 10.9 BANK1 FCGR2B PTPN22
58 immunodeficiency due to a classical component pathway complement deficiency 10.9 C4A C4B
59 autoimmune addison disease 10.8 CTLA4 PTPN22
60 transient neonatal neutropenia 10.8 FCGR3A TRIM21
61 arthritis 10.8
62 juvenile dermatitis herpetiformis 10.8 C4A C4B
63 myasthenic syndrome, congenital, 7, presynaptic 10.8 CTLA4 PDCD1
64 rheumatoid arthritis 10.8
65 anterior uveitis 10.8 CTLA4 PTPN22
66 adult lymphoma 10.7 FCGR2A FCGR3A
67 orbital plasma cell granuloma 10.7 CTLA4 FCGR3A
68 sympathetic ophthalmia 10.7 CTLA4 PDCD1
69 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.7
70 antiphospholipid syndrome 10.6
71 poliomyelitis 10.6 FCGR2A FCGR3A
72 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.5
73 thrombosis 10.5
74 myelitis 10.5
75 endotheliitis 10.5
76 vasculitis 10.5
77 connective tissue disease 10.5
78 transverse myelitis 10.5
79 protein-losing enteropathy 10.5
80 purpura 10.4
81 retinitis 10.4
82 cerebritis 10.4
83 chronic orbital inflammation 10.4 CTLA4 FCGR3A
84 glomerulonephritis 10.4
85 scleroderma, familial progressive 10.4
86 hepatitis 10.4
87 lymphoma 10.4
88 diffuse alveolar hemorrhage 10.4
89 thyroiditis 10.4
90 intestinal pseudo-obstruction 10.4
91 discoid lupus erythematosus 10.4
92 thrombocytopenia 10.3
93 thrombotic thrombocytopenic purpura 10.3
94 lymphopenia 10.3
95 dermatomyositis 10.3
96 autoimmune disease 1 10.3
97 cardiac tamponade 10.3
98 blood group, i system 10.3
99 mycobacterium tuberculosis 1 10.3
100 arthropathy 10.3
101 meningitis 10.3
102 aging 10.3
103 osteonecrosis 10.3
104 pneumonia 10.3
105 atrial standstill 1 10.2
106 hemolytic anemia 10.2
107 rheumatic disease 10.2
108 aneurysm 10.2
109 vascular disease 10.2
110 cholecystitis 10.2
111 multiple sclerosis 10.2
112 heart block, congenital 10.2
113 myocardial infarction 10.2
114 autoimmune hepatitis 10.2
115 porphyria 10.2
116 acalculous cholecystitis 10.2
117 nervous system disease 10.2
118 myasthenia gravis 10.2
119 membranous nephropathy 10.2
120 panniculitis 10.2
121 central nervous system disease 10.2
122 pancreatitis 10.2
123 complement deficiency 10.2
124 progressive multifocal leukoencephalopathy 10.2
125 juvenile rheumatoid arthritis 10.2
126 fasciitis 10.2
127 myasthenia gravis congenital 10.2
128 anemia, autoimmune hemolytic 10.2
129 hyperprolactinemia 10.2
130 optic neuritis 10.2
131 neuritis 10.2
132 dermatitis 10.2
133 myocarditis 10.2
134 herpes zoster 10.2
135 neuropathy 10.2
136 chorea, childhood-onset, with psychomotor retardation 10.2
137 pulmonary hypertension 10.2
138 neutropenia 10.2
139 renal tubular acidosis 10.2
140 retinal vasculitis 10.2
141 choreatic disease 10.2
142 hypothyroidism 10.2
143 calcinosis 10.2
144 pemphigus 10.2
145 bronchiolitis obliterans 10.1
146 leukemia 10.1
147 bronchiolitis 10.1
148 calciphylaxis 10.1
149 subacute cutaneous lupus erythematosus 10.1
150 hashimoto thyroiditis 10.1
151 familial mediterranean fever 10.1
152 meningoencephalitis 10.1
153 brucellosis 10.1
154 heart disease 10.1
155 hemopericardium 10.1
156 polyneuropathy 10.1
157 pericarditis 10.1
158 epidermolysis bullosa 10.1
159 polyradiculoneuropathy 10.1
160 granulomatous dermatitis 10.1
161 proliferative glomerulonephritis 10.1
162 intracranial hypertension 10.1
163 polymyositis 10.1
164 ring chromosome y syndrome 10.1
165 fibrosis of extraocular muscles, congenital, 1 10.1
166 myositis 10.1
167 pernicious anemia 10.1
168 porphyria cutanea tarda 10.1
169 intracranial hypertension, idiopathic 10.1
170 thymoma, familial 10.1
171 meester-loeys syndrome 10.1
172 complement component 4a deficiency 10.1
173 episodic pain syndrome, familial, 1 10.1
174 diabetes mellitus 10.1
175 systemic scleroderma 10.1
176 choroiditis 10.1
177 pericardial effusion 10.1
178 nocardiosis 10.1
179 acute pancreatitis 10.1
180 thymoma 10.1
181 myopathy 10.1
182 necrotizing fasciitis 10.1
183 hemophilia 10.1
184 catastrophic antiphospholipid syndrome 10.1
185 encephalopathy 10.1
186 headache 10.1
187 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.1
188 thrombophilia due to thrombin defect 10.0
189 leprosy 3 10.0
190 severe cutaneous adverse reaction 10.0
191 b-cell lymphomas 10.0
192 hydrocephalus 10.0
193 neuromyelitis optica 10.0
194 endocarditis 10.0
195 strongyloidiasis 10.0
196 aseptic meningitis 10.0
197 central retinal artery occlusion 10.0
198 angioedema 10.0
199 lymphadenitis 10.0
200 protein s deficiency 10.0
201 cryoglobulinemia 10.0
202 aortic aneurysm 10.0
203 internuclear ophthalmoplegia 10.0
204 peritonitis 10.0
205 influenza 10.0
206 retinal artery occlusion 10.0
207 collagen disease 10.0
208 miliary tuberculosis 10.0
209 acquired hemophilia 10.0
210 acute transverse myelitis 10.0
211 arteries, anomalies of 10.0
212 biliary cirrhosis, primary, 1 10.0
213 complement component 4, partial deficiency of 10.0
214 noonan syndrome 1 10.0
215 porphyria, acute intermittent 10.0
216 cardiac valvular defect, developmental 10.0
217 heart valve disease 10.0
218 hepatitis b 10.0
219 primary biliary cirrhosis 10.0
220 c1 inhibitor deficiency 10.0
221 cytomegalovirus retinitis 10.0
222 hypoparathyroidism 10.0
223 nephrotic syndrome 10.0
224 cryptococcosis 10.0
225 pancytopenia 10.0
226 hellp syndrome 10.0
227 pneumatosis cystoides intestinalis 10.0
228 hyperparathyroidism 10.0
229 cystitis 10.0
230 epilepsy 10.0
231 acute myocarditis 10.0
232 aortitis 10.0
233 demyelinating polyneuropathy 10.0
234 septic arthritis 10.0
235 periodontitis 10.0
236 pyomyositis 10.0
237 encephalitis 10.0
238 linear scleroderma 10.0
239 nodular regenerative hyperplasia 10.0
240 pseudo-turner syndrome 10.0
241 cerebral atrophy 10.0
242 lupus erythematosus panniculitis 10.0
243 spondyloarthropathy 1 10.0
244 cryoglobulinemia, familial mixed 10.0
245 lymphoma, mucosa-associated lymphoid type 10.0
246 hypercalcemia, infantile, 1 10.0
247 prolidase deficiency 10.0
248 celiac disease 1 10.0
249 eosinophilic fasciitis 10.0
250 epidermodysplasia verruciformis 10.0
251 premature ovarian failure 1 10.0
252 ataxia and polyneuropathy, adult-onset 10.0
253 coronary heart disease 1 10.0
254 avascular necrosis of femoral head, primary, 1 10.0
255 aplastic anemia 10.0
256 aspergillosis 10.0
257 mannose-binding lectin deficiency 10.0
258 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.0
259 polyarteritis nodosa, childhood-onset 10.0
260 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
261 acute myocardial infarction 10.0
262 alopecia 10.0
263 childhood type dermatomyositis 10.0
264 common variable immunodeficiency 10.0
265 hemophagocytic lymphohistiocytosis 10.0
266 osteoarthritis 10.0
267 pulmonary sarcoidosis 10.0
268 silicosis 10.0
269 colitis 10.0
270 salmonellosis 10.0
271 pleurisy 10.0
272 inflammatory spondylopathy 10.0
273 jaccoud's syndrome 10.0
274 amenorrhea 10.0
275 adult dermatomyositis 10.0
276 histoplasmosis 10.0
277 mononeuritis multiplex 10.0
278 coronary aneurysm 10.0
279 cranial nerve palsy 10.0
280 syphilis 10.0
281 pyoderma 10.0
282 chronic inflammatory demyelinating polyradiculoneuropathy 10.0
283 kidney disease 10.0
284 spondylitis 10.0
285 neuronitis 10.0
286 lung disease 10.0
287 pyoderma gangrenosum 10.0
288 anca-associated vasculitis 10.0
289 cytomegalovirus infection 10.0
290 keratitis, hereditary 9.9
291 lymphedema, hereditary, ii 9.9
292 dowling-degos disease 1 9.9
293 chondrodysplasia punctata syndrome 9.9
294 lysinuric protein intolerance 9.9
295 myelofibrosis 9.9
296 popliteal pterygium syndrome, lethal type 9.9
297 rheumatic fever-related antigen 9.9
298 pituitary adenoma, prolactin-secreting 9.9
299 asthma 9.9
300 malignant atrophic papulosis 9.9
301 focal segmental glomerulosclerosis 1 9.9
302 aceruloplasminemia 9.9
303 osteoarthritis with mild chondrodysplasia 9.9
304 wegener granulomatosis 9.9
305 malaria 9.9
306 kawasaki disease 9.9
307 complement component 4b deficiency 9.9
308 ataxia-oculomotor apraxia 3 9.9
309 glucocorticoid resistance, generalized 9.9
310 hydrops, lactic acidosis, and sideroblastic anemia 9.9
311 multiple mitochondrial dysfunctions syndrome 5 9.9
312 peripheral vascular disease 9.9
313 tendinitis 9.9
314 acute lymphocytic leukemia 9.9
315 chronic inflammatory demyelinating polyneuropathy 9.9
316 coronary artery anomaly 9.9
317 focal segmental glomerulosclerosis 9.9
318 hematopoietic stem cell transplantation 9.9
319 pemphigus foliaceus 9.9
320 retinal vein occlusion 9.9
321 erythema multiforme 9.9
322 lambert-eaton myasthenic syndrome 9.9
323 alexithymia 9.9
324 sensorineural hearing loss 9.9
325 tuberculoid leprosy 9.9
326 parotitis 9.9
327 lepromatous leprosy 9.9
328 hydronephrosis 9.9
329 respiratory failure 9.9
330 disseminated intravascular coagulation 9.9
331 portal vein thrombosis 9.9
332 secondary hyperparathyroidism of renal origin 9.9
333 uveitis 9.9
334 interstitial cystitis 9.9
335 adult-onset still's disease 9.9
336 pyuria 9.9
337 candidiasis 9.9
338 urticaria 9.9
339 communicating hydrocephalus 9.9
340 rheumatic fever 9.9
341 chronic interstitial cystitis 9.9
342 hepatitis c 9.9
343 arteriosclerosis 9.9
344 relapsing polychondritis 9.9
345 membranoproliferative glomerulonephritis 9.9
346 cellulitis 9.9
347 central nervous system vasculitis 9.9
348 acquired immunodeficiency syndrome 9.9
349 acute disseminated encephalomyelitis 9.9
350 cerebrovascular disease 9.9
351 bullous pemphigoid 9.9
352 herpes simplex 9.9
353 lichen planus 9.9
354 acquired von willebrand syndrome 9.9
355 heparin-induced thrombocytopenia 9.9
356 hypoaldosteronism 9.9
357 hyporeninemic hypoaldosteronism 9.9
358 mycobacterium kansasii 9.9
359 retroperitoneal fibrosis 9.9
360 zygomycosis 9.9
361 pemphigus erythematosus 9.9
362 refractory anemia 9.9
363 acanthosis nigricans 9.8
364 b-cell growth factor 9.8
365 blood group--diego system 9.8
366 inclusion body myositis 9.8
367 migraine with or without aura 1 9.8
368 pulmonary hemosiderosis 9.8
369 spherocytosis, type 1 9.8
370 ascites, chylous 9.8
371 hemolytic uremic syndrome, atypical 1 9.8
372 hydrocephalus, normal-pressure 9.8
373 myeloma, multiple 9.8
374 body mass index quantitative trait locus 11 9.8
375 fabry disease 9.8
376 hemophilia a 9.8
377 taqi polymorphism 9.8
378 budd-chiari syndrome 9.8
379 dermatitis herpetiformis, familial 9.8
380 stroke, ischemic 9.8
381 autoimmune lymphoproliferative syndrome 9.8
382 body mass index quantitative trait locus 9 9.8
383 body mass index quantitative trait locus 8 9.8
384 reflex sympathetic dystrophy 9.8
385 orthostatic intolerance 9.8
386 psoriatic arthritis 9.8
387 anxiety 9.8
388 body mass index quantitative trait locus 7 9.8
389 body mass index quantitative trait locus 12 9.8
390 factor xi deficiency 9.8
391 body mass index quantitative trait locus 14 9.8
392 dengue virus 9.8
393 graft-versus-host disease 9.8
394 peripartum cardiomyopathy 9.8
395 body mass index quantitative trait locus 18 9.8
396 aortic atherosclerosis 9.8
397 chronic kidney failure 9.8
398 crohn's disease 9.8
399 dengue disease 9.8
400 marginal zone b-cell lymphoma 9.8
401 paroxysmal nocturnal hemoglobinuria 9.8
402 pulmonary fibrosis 9.8
403 skin disease 9.8
404 temporal lobe epilepsy 9.8
405 invasive aspergillosis 9.8
406 peripheral artery disease 9.8
407 inflammatory myofibroblastic tumor 9.8
408 immunoglobulin alpha deficiency 9.8
409 collagenous colitis 9.8
410 purpura fulminans 9.8
411 lymphoproliferative syndrome 9.8
412 cryptococcal meningitis 9.8
413 osteomyelitis 9.8
414 mastitis 9.8
415 q fever 9.8
416 henoch-schoenlein purpura 9.8
417 t cell deficiency 9.8
418 spondyloarthropathy 9.8
419 tetanus 9.8
420 dysgammaglobulinemia 9.8
421 conn's syndrome 9.8
422 hemosiderosis 9.8
423 pulmonary alveolar proteinosis 9.8
424 neurogenic bladder 9.8
425 graves' disease 9.8
426 hemolytic-uremic syndrome 9.8
427 tolosa-hunt syndrome 9.8
428 guillain-barre syndrome 9.8
429 crescentic glomerulonephritis 9.8
430 gout 9.8
431 algoneurodystrophy 9.8
432 neuroleptic malignant syndrome 9.8
433 hereditary angioedema 9.8
434 diffuse scleroderma 9.8
435 thrombocytopenia due to platelet alloimmunization 9.8
436 renovascular hypertension 9.8
437 squamous cell carcinoma 9.8
438 chronic mucocutaneous candidiasis 9.8
439 thrombocytosis 9.8
440 gastroenteritis 9.8
441 central retinal vein occlusion 9.8
442 retinal vascular disease 9.8
443 kluver-bucy syndrome 9.8
444 splenic abscess 9.8
445 splenic infarction 9.8
446 cervicitis 9.8
447 papilloma 9.8
448 synovitis 9.8
449 bursitis 9.8
450 interstitial lung disease 9.8
451 proctitis 9.8
452 nemaline myopathy 9.8
453 ischemia 9.8
454 periodontal disease 9.8
455 histiocytosis 9.8
456 sagittal sinus thrombosis 9.8
457 shwartzman phenomenon 9.8
458 eosinophilic gastroenteritis 9.8
459 polyradiculopathy 9.8
460 tinea capitis 9.8
461 cerebral lymphoma 9.8
462 hemoglobinuria 9.8
463 reactive arthritis 9.8
464 pericardial mesothelioma 9.8
465 adenoma 9.8
466 anterior spinal artery syndrome 9.8
467 axonal neuropathy 9.8
468 hyperthyroidism 9.8
469 scabies 9.8
470 paralytic ileus 9.8
471 localized scleroderma 9.8
472 dermatitis herpetiformis 9.8
473 malignant histiocytosis 9.8
474 scotoma 9.8
475 carotid artery dissection 9.8
476 exophthalmos 9.8
477 epiglottitis 9.8
478 tenosynovitis 9.8
479 polyarteritis nodosa 9.8
480 deep keratitis 9.8
481 hypereosinophilic syndrome 9.8
482 hypoglycemia 9.8
483 acquired hemophilia a 9.8
484 amaurosis fugax 9.8
485 chronic active epstein-barr virus infection 9.8
486 chronic graft versus host disease 9.8
487 coronary artery aneurysm 9.8
488 gigantism 9.8
489 gigantomastia 9.8
490 hyper ige syndrome 9.8
491 hypocomplementemic urticarial vasculitis 9.8
492 kikuchi disease 9.8
493 lymphocytic hypophysitis 9.8
494 malakoplakia 9.8
495 mycobacterium fortuitum 9.8
496 oral lichen planus 9.8
497 papular mucinosis 9.8
498 reversible cerebral vasoconstriction syndrome 9.8
499 rosai-dorfman disease 9.8
500 sudden sensorineural hearing loss 9.8
501 autonomic dysfunction 9.8
502 pseudo-meigs syndrome 9.8
503 paraneoplastic pemphigus 9.8
504 cardiogenic shock 9.8
505 cytophagic histiocytic panniculitis 9.8
506 acroosteolysis 9.7
507 breast cancer 9.7
508 colorectal cancer 9.7
509 cardiac conduction defect 9.7
510 periodic fever, familial, autosomal dominant 9.7
511 hypertriglyceridemia, familial 9.7
512 immune suppression 9.7
513 intussusception 9.7
514 lichen sclerosus et atrophicus 9.7
515 moebius syndrome 9.7
516 myelopathy, htlv-1-associated 9.7
517 osteoporosis 9.7
518 pemphigus vulgaris, familial 9.7
519 prader-willi syndrome 9.7
520 protoporphyria, erythropoietic 9.7
521 pulmonary hypertension, primary, 1 9.7
522 schizophrenia 9.7
523 spinocerebellar ataxia 6 9.7
524 stiff-person syndrome 9.7
525 thyroid cancer, nonmedullary, 1 9.7
526 torticollis 9.7
527 trichomegaly 9.7
528 trichorhinophalangeal syndrome, type i 9.7
529 trigeminal neuralgia 9.7
530 acid phosphatase deficiency 9.7
531 alopecia universalis congenita 9.7
532 takayasu arteritis 9.7
533 arterial calcification, generalized, of infancy, 1 9.7
534 cystic fibrosis 9.7
535 disorganization, mouse, homolog of 9.7
536 galactorrhea 9.7
537 factor xii deficiency 9.7
538 dubin-johnson syndrome 9.7
539 hypogonadism, male 9.7
540 mannosidosis, alpha b, lysosomal 9.7
541 moyamoya disease 1 9.7
542 mycosis fungoides 9.7
543 pancreatic agenesis 1 9.7
544 pituitary hormone deficiency, combined, 2 9.7
545 pseudoxanthoma elasticum 9.7
546 thrombotic thrombocytopenic purpura, congenital 9.7
547 graves disease 1 9.7
548 wiskott-aldrich syndrome 9.7
549 immunodeficiency with hyper-igm, type 1 9.7
550 mental retardation, x-linked, syndromic, snyder-robinson type 9.7
551 transsexuality 9.7
552 cerebellar degeneration-related autoantigen 3 9.7
553 branchiootic syndrome 1 9.7
554 bile duct cysts 9.7
555 macular degeneration, age-related, 1 9.7
556 homocysteinemia 9.7
557 ventricular fibrillation, paroxysmal familial, 1 9.7
558 rheumatoid arthritis, systemic juvenile 9.7
559 cataract 2, multiple types 9.7
560 body mass index quantitative trait locus 1 9.7
561 lymphangioleiomyomatosis 9.7
562 aortic aneurysm, familial thoracic 1 9.7
563 resting heart rate, variation in 9.7
564 body mass index quantitative trait locus 4 9.7
565 body mass index quantitative trait locus 10 9.7
566 juvenile myelomonocytic leukemia 9.7
567 endometrial cancer 9.7
568 ovarian hyperstimulation syndrome 9.7
569 kala-azar 1 9.7
570 carotid intimal medial thickness 2 9.7
571 malaria, mild 9.7
572 bulimia nervosa 2 9.7
573 pulmonary alveolar proteinosis, acquired 9.7
574 bone mineral density quantitative trait locus 8 9.7
575 antithrombin iii deficiency 9.7
576 bone mineral density quantitative trait locus 15 9.7
577 cholangitis, primary sclerosing 9.7
578 bacteremia 2 9.7
579 hypertriglyceridemia, transient infantile 9.7
580 human herpesvirus 8 9.7
581 melioidosis 9.7
582 alpha-fetoprotein deficiency 9.7
583 chops syndrome 9.7
584 cohen-gibson syndrome 9.7
585 adult respiratory distress syndrome 9.7
586 adult t-cell leukemia 9.7
587 bipolar disorder 9.7
588 burns 9.7
589 cerebral hemorrhage 9.7
590 chronic granulomatous disease 9.7
591 chronic myelomonocytic leukemia 9.7
592 diffuse large b-cell lymphoma 9.7
593 granuloma annulare 9.7
594 hemangioma 9.7
595 intraocular lymphoma 9.7
596 liver cirrhosis 9.7
597 liver disease 9.7
598 lymphomatoid granulomatosis 9.7
599 mannosidosis 9.7
600 pemphigus vulgaris 9.7
601 ulcerative colitis 9.7
602 chikungunya 9.7
603 autoimmune polyendocrine syndrome type 1 9.7
604 swine influenza 9.7
605 hypophosphatemia 9.7
606 inflammatory bowel disease 9.7
607 extrapulmonary tuberculosis 9.7
608 abdominal tuberculosis 9.7
609 t-cell large granular lymphocyte leukemia 9.7
610 rheumatic heart disease 9.7
611 hemorrhagic cystitis 9.7
612 villous adenoma 9.7
613 infective endocarditis 9.7
614 cd40 ligand deficiency 9.7
615 atrial fibrillation 9.7
616 erythema elevatum diutinum 9.7
617 hyperekplexia 1 9.7
618 meningococcal meningitis 9.7
619 mucositis 9.7
620 syphilitic meningitis 9.7
621 cysticercosis 9.7
622 venous insufficiency 9.7
623 dry eye syndrome 9.7
624 neuroretinitis 9.7
625 asbestosis 9.7
626 chronic meningitis 9.7
627 hypopyon 9.7
628 glucose intolerance 9.7
629 paragonimiasis 9.7
630 portal hypertension 9.7
631 methemoglobinemia 9.7
632 malignant hypertension 9.7
633 transsexualism 9.7
634 intracranial aneurysm 9.7
635 sarcoma 9.7
636 enophthalmos 9.7
637 primary hyperparathyroidism 9.7
638 vitamin k deficiency hemorrhagic disease 9.7
639 cat-scratch disease 9.7
640 lemierre's syndrome 9.7
641 epidural abscess 9.7
642 subdural empyema 9.7
643 pulmonary edema 9.7
644 pyelonephritis 9.7
645 xanthogranulomatous pyelonephritis 9.7
646 diphtheria 9.7
647 constrictive pericarditis 9.7
648 autonomic neuropathy 9.7
649 hypertensive retinopathy 9.7
650 cicatricial pemphigoid 9.7
651 palindromic rheumatism 9.7
652 lyme disease 9.7
653 multicentric reticulohistiocytosis 9.7
654 myopia 9.7
655 cortical blindness 9.7
656 mononeuropathy 9.7
657 ecthyma 9.7
658 esophagitis 9.7
659 allergic hypersensitivity disease 9.7
660 chagas disease 9.7
661 pseudoretinitis pigmentosa 9.7
662 superficial keratitis 9.7
663 von willebrand's disease 9.7
664 pyloric stenosis 9.7
665 paracoccidioidomycosis 9.7
666 nephrocalcinosis 9.7
667 hypercementosis 9.7
668 miller fisher syndrome 9.7
669 endomyocardial fibrosis 9.7
670 eumycotic mycetoma 9.7
671 typhoid fever 9.7
672 scleritis 9.7
673 tuberous sclerosis 9.7
674 posterior scleritis 9.7
675 hepatic infarction 9.7
676 hypermobility syndrome 9.7
677 necrotizing ulcerative gingivitis 9.7
678 facial paralysis 9.7
679 splenic artery aneurysm 9.7
680 poems syndrome 9.7
681 autoimmune polyendocrine syndrome 9.7
682 bipolar i disorder 9.7
683 neonatal myasthenia gravis 9.7
684 phaeohyphomycosis 9.7
685 toxic shock syndrome 9.7
686 obstructive hydrocephalus 9.7
687 selective igg deficiency disease 9.7
688 oral candidiasis 9.7
689 sclerosing cholangitis 9.7
690 suppurative thyroiditis 9.7
691 autosomal dominant cerebellar ataxia 9.7
692 herpes gestationis 9.7
693 chorea gravidarum 9.7
694 reye syndrome 9.7
695 papilledema 9.7
696 prostatitis 9.7
697 chromoblastomycosis 9.7
698 central nervous system tuberculosis 9.7
699 ichthyosis 9.7
700 retinal vascular occlusion 9.7
701 mitral valve stenosis 9.7
702 cheilitis 9.7
703 status epilepticus 9.7
704 impotence 9.7
705 hyperuricemia 9.7
706 hypogonadism 9.7
707 intestinal perforation 9.7
708 blood platelet disease 9.7
709 granulomatous hepatitis 9.7
710 pharyngitis 9.7
711 pigmented villonodular synovitis 9.7
712 pulmonary tuberculosis 9.7
713 kidney cortex necrosis 9.7
714 gingivitis 9.7
715 cutis laxa 9.7
716 lipomatosis 9.7
717 tropical spastic paraparesis 9.7
718 tracheal stenosis 9.7
719 teratocarcinoma 9.7
720 teratoma 9.7
721 hyperglobulinemic purpura 9.7
722 liposarcoma 9.7
723 laryngitis 9.7
724 turner syndrome 9.7
725 superior mesenteric artery syndrome 9.7
726 brachial plexus neuropathy 9.7
727 hermansky-pudlak syndrome 9.7
728 anovulation 9.7
729 porokeratosis 9.7
730 thrombophlebitis 9.7
731 loeffler endocarditis 9.7
732 restrictive cardiomyopathy 9.7
733 gastritis 9.7
734 secondary syphilis 9.7
735 pseudohypoparathyroidism 9.7
736 echolalia 9.7
737 hypertrichosis 9.7
738 pustulosis of palm and sole 9.7
739 macular retinal edema 9.7
740 large cell carcinoma 9.7
741 hydranencephaly 9.7
742 intracranial hypotension 9.7
743 subacute glomerulonephritis 9.7
744 cavernous hemangioma 9.7
745 gerstmann syndrome 9.7
746 arteriosclerosis obliterans 9.7
747 aortic disease 9.7
748 blepharospasm 9.7
749 sleep disorder 9.7
750 pulmonary venoocclusive disease 9.7
751 anal squamous cell carcinoma 9.7
752 diffuse pulmonary fibrosis 9.7
753 retinal disease 9.7
754 aortic valve insufficiency 9.7
755 inferior myocardial infarction 9.7
756 brown-sequard syndrome 9.7
757 mitral valve disease 9.7
758 conjunctivitis 9.7
759 central pontine myelinolysis 9.7
760 adrenal adenoma 9.7
761 bilateral breast cancer 9.7
762 compartment syndrome 9.7
763 t-cell leukemia 9.7
764 subacute thyroiditis 9.7
765 nodular episcleritis 9.7
766 hemarthrosis 9.7
767 carotid artery occlusion 9.7
768 lipodystrophy 9.7
769 mediastinitis 9.7
770 actinomycosis 9.7
771 impetigo 9.7
772 subcorneal pustular dermatosis 9.7
773 hodgkin's lymphoma, lymphocytic-histiocytic predominance 9.7
774 subacute delirium 9.7
775 psoriasis 9.7
776 dermatophytosis 9.7
777 evans' syndrome 9.7
778 sideroblastic anemia 9.7
779 liver lymphoma 9.7
780 leishmaniasis 9.7
781 amyloidosis 9.7
782 peliosis hepatis 9.7
783 visceral leishmaniasis 9.7
784 erythromelalgia 9.7
785 priapism 9.7
786 iridocyclitis 9.7
787 diabetes insipidus 9.7
788 blepharitis 9.7
789 cholangitis 9.7
790 bacterial meningitis 9.7
791 dacryoadenitis 9.7
792 dextrocardia 9.7
793 babesiosis 9.7
794 renal tuberculosis 9.7
795 diastolic heart failure 9.7
796 irritable bowel syndrome 9.7
797 tuberculous peritonitis 9.7
798 hypersensitivity vasculitis 9.7
799 alopecia areata 9.7
800 median arcuate ligament syndrome 9.7
801 villonodular synovitis 9.7
802 follicular mucinosis 9.7
803 periostitis 9.7
804 toxoplasmosis 9.7
805 sickle cell disease 9.7
806 trichorhinophalangeal syndrome 9.7
807 acquired generalized lipodystrophy 9.7
808 acquired hypoprothrombinemia 9.7
809 angioimmunoblastic t-cell lymphoma 9.7
810 anton's syndrome 9.7
811 autoimmune myocarditis 9.7
812 autoimmune retinopathy 9.7
813 bone marrow necrosis 9.7
814 bowen's disease 9.7
815 bowenoid papulosis 9.7
816 cardiac rupture 9.7
817 castleman disease 9.7
818 central serous chorioretinopathy 9.7
819 chorea minor 9.7
820 cold agglutinin disease 9.7
821 congenital cytomegalovirus 9.7
822 embryonal sarcoma 9.7
823 eosinophilic granulomatosis with polyangiitis 9.7
824 fibrillary glomerulonephritis 9.7
825 germ cells tumors 9.7
826 giant cell myocarditis 9.7
827 granulocytopenia 9.7
828 granulomatous lobular mastitis 9.7
829 haemophilus influenzae 9.7
830 ichthyosis, acquired 9.7
831 large granular lymphocyte leukemia 9.7
832 lichen sclerosus 9.7
833 limbic encephalitis 9.7
834 linear iga disease 9.7
835 lymphocytic vasculitis 9.7
836 meningococcal infection 9.7
837 microscopic polyangiitis 9.7
838 mollaret meningitis 9.7
839 multicentric castleman disease 9.7
840 muscular dystrophy white matter spongiosis 9.7
841 mycetoma 9.7
842 mycobacterium chelonae 9.7
843 mycobacterium marinum 9.7
844 mycobacterium xenopi 9.7
845 necrotizing autoimmune myopathy 9.7
846 neuromyelitis optica spectrum disorder 9.7
847 nontuberculous mycobacterial lung disease 9.7
848 pasteurella multocida infection 9.7
849 pdgfrb-associated chronic eosinophilic leukemia 9.7
850 retroperitoneal liposarcoma 9.7
851 serpiginous choroiditis 9.7
852 spastic paraparesis 9.7
853 splenomegaly 9.7
854 streptococcal group a invasive disease 9.7
855 synovial chondromatosis 9.7
856 syphilitic aseptic meningitis 9.7
857 systemic onset juvenile idiopathic arthritis 9.7
858 t-cell/histiocyte rich large b cell lymphoma 9.7
859 tetrasomy x 9.7
860 thrombasthenia 9.7
861 thymic hyperplasia 9.7
862 trochleitis 9.7
863 tuberculous meningitis 9.7
864 ulcerative proctitis 9.7
865 wells syndrome 9.7
866 central cord syndrome 9.7
867 dysautonomia 9.7
868 extrapontine myelinolysis 9.7
869 hypertonia 9.7
870 myoclonus 9.7
871 paraneoplastic syndromes 9.7
872 spasticity 9.7
873 syncope 9.7
874 undifferentiated embryonal sarcoma of the liver 9.7
875 asbestos intoxication 9.7
876 vulvar intraepithelial neoplasia 9.7
877 acquired cutis laxa 9.7
878 phalangeal microgeodic syndrome 9.7
879 tafro syndrome 9.7
880 transient neonatal myasthenia gravis 9.7
881 juvenile myasthenia gravis 9.7
882 systemic polyarteritis nodosa 9.7
883 spontaneous intracranial hypotension 9.7
884 acute macular neuroretinopathy 9.7
885 recurrent acute pancreatitis 9.7
886 hepatosplenic t-cell lymphoma 9.7
887 solar urticaria 9.7
888 acute adrenal insufficiency 9.7
889 atlantoaxial subluxation 9.7
890 intravascular large b-cell lymphoma 9.7
891 ischemic retinopathy 9.7
892 osteoporotic fracture 9.7
893 microvascular complications of diabetes 3 9.6
894 microvascular complications of diabetes 4 9.6
895 microvascular complications of diabetes 6 9.6
896 microvascular complications of diabetes 7 9.6

Comorbidity relations with Systemic Lupus Erythematosus via Phenotypic Disease Network (PDN): (showing 20, show less)


Acute Cystitis Chronic Kidney Failure
Chronic Myocardial Ischemia Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
Heart Disease Hypersensitivity Vasculitis
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease Neutropenia
Osteoporosis Postinflammatory Pulmonary Fibrosis
Raynaud Disease Rheumatoid Arthritis
Sjogren Syndrome Systemic Scleroderma

Graphical network of the top 20 diseases related to Systemic Lupus Erythematosus:



Diseases related to Systemic Lupus Erythematosus

Symptoms & Phenotypes for Systemic Lupus Erythematosus

Symptoms via clinical synopsis from OMIM:

53
Neurologic Central Nervous System:
seizures
psychosis

Hematology:
hemolytic anemia
thrombocytopenia
leukopenia

Respiratory Lung:
pleuritis

Genitourinary Kidneys:
nephritis

Laboratory Abnormalities:
antiphospholipid antibody
anti dsdna antibody
serum antinuclear antibody

Skeletal Limbs:
arthritis

Cardiovascular Heart:
pericarditis

Immunology:
systemic lupus erythematosus

Skin Nails Hair Skin:
photosensitivity
erythematous malar rash
discoid rash


Clinical features from OMIM:

152700

Human phenotypes related to Systemic Lupus Erythematosus:

31 (showing 13, show less)
# Description HPO Frequency HPO Source Accession
1 seizures 31 HP:0001250
2 arthritis 31 HP:0001369
3 hemolytic anemia 31 HP:0001878
4 thrombocytopenia 31 HP:0001873
5 psychosis 31 HP:0000709
6 pericarditis 31 HP:0001701
7 cutaneous photosensitivity 31 HP:0000992
8 leukopenia 31 HP:0001882
9 pleuritis 31 HP:0002102
10 systemic lupus erythematosus 31 HP:0002725
11 antinuclear antibody positivity 31 HP:0003493
12 nephritis 31 HP:0000123
13 antiphospholipid antibody positivity 31 HP:0003613

UMLS symptoms related to Systemic Lupus Erythematosus:


seizures, pruritus, heliotrope rash, lupus-like rash, exanthema

MGI Mouse Phenotypes related to Systemic Lupus Erythematosus:

43 (showing 6, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 CTLA4 DNASE1 ENG FCGR2A FCGR2B PDCD1
2 immune system MP:0005387 10 BANK1 C4B CTLA4 DNASE1 FCGR2A FCGR2B
3 digestive/alimentary MP:0005381 9.91 C4B CTLA4 ENG FCGR2B PTPN22 TLR5
4 liver/biliary system MP:0005370 9.7 C4B CTLA4 FCGR2B PDCD1 PTPN22 TLR5
5 renal/urinary system MP:0005367 9.5 DNASE1 FCGR2B PDCD1 PTPN22 TREX1 TRIM21
6 respiratory system MP:0005388 9.17 CTLA4 ENG FCGR2B PDCD1 PTPN22 TLR5

Drugs & Therapeutics for Systemic Lupus Erythematosus

Drugs for Systemic Lupus Erythematosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 362, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 4,Phase 1,Early Phase 1 79902-63-9 54454
2
Everolimus Approved Phase 4,Phase 2 159351-69-6 6442177
3
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
4
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
5
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
6
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
7
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
8
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 53-03-2 5865
9
Sirolimus Approved, Investigational Phase 4,Phase 2 53123-88-9 46835353 6436030 5284616
10
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 104987-11-3 445643 439492
11
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 50-18-0, 6055-19-2 2907
12
belimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 356547-88-1 5957 10451420
13
Pioglitazone Approved, Investigational Phase 4,Phase 1,Phase 2 111025-46-8 4829
14
Hydroxychloroquine Approved Phase 4,Phase 3,Phase 1,Phase 2 118-42-3 3652
15
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 1 50-78-2 2244
16
Azathioprine Approved Phase 4,Phase 3,Phase 2,Phase 1 446-86-6 2265
17
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
18
Lenalidomide Approved Phase 4 191732-72-6 216326
19
Sulfamethoxazole Approved Phase 4 723-46-6 5329
20
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
21
Thioguanine Approved Phase 4 154-42-7 2723601
22
Metformin Approved Phase 4 657-24-9 4091 14219
23
Vincristine Approved, Investigational Phase 4 2068-78-2, 57-22-7 5978
24
Calcitriol Approved, Nutraceutical Phase 4,Phase 2 32222-06-3 5280453 134070
25
Alfacalcidol Approved, Nutraceutical Phase 4 41294-56-8 5282181
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
27
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 143 6006
28
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 1 50-14-6 5280793
29
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 1406-16-2
30 Anticholesteremic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
31 Antimetabolites Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
32 Calcium, Dietary Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
33 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
34 Hypolipidemic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
35 Lipid Regulating Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
36 Rosuvastatin Calcium Phase 4,Phase 2,Phase 1 147098-20-2
37 Vaccines Phase 4,Phase 2,Phase 3,Phase 1
38 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
39 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
40 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1
41 Antifungal Agents Phase 4,Phase 2,Phase 1
42 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
44 Antilymphocyte Serum Phase 4,Phase 2,Phase 1
45 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
46 Antitubercular Agents Phase 4,Phase 3,Phase 2,Phase 1
47 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1
48 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
49 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
50 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
51 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
52 Hormones Phase 4,Phase 3,Phase 2,Phase 1
53 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
54 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
55 Methylprednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1
56 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2,Phase 1
57 Neuroprotective Agents Phase 4,Phase 3,Phase 2,Phase 1
58 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
59 Prednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1
60 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2,Phase 1
61 Prednisolone phosphate Phase 4,Phase 3,Phase 2,Phase 1
62 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
63 Antibodies Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
64 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
65 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
66 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3,Phase 1
67 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1
68 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1
69 Vitamins Phase 4,Phase 3,Phase 2,Phase 1
70 Estrogens Phase 4,Phase 3,Phase 2,Phase 1
71 Atorvastatin Calcium Phase 4,Phase 2,Phase 3,Phase 1 134523-03-8
72 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1
73 Autoantibodies Phase 4,Phase 2,Phase 3,Phase 1
74 Cyclosporins Phase 4,Phase 2,Phase 1
75 Vasoconstrictor Agents Phase 4,Phase 2
76 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 2,Phase 3
77 Hypoglycemic Agents Phase 4,Phase 1,Phase 2
78 Antimalarials Phase 4,Phase 3,Phase 1,Phase 2
79 Antiparasitic Agents Phase 4,Phase 3,Phase 1,Phase 2
80 Antiprotozoal Agents Phase 4,Phase 3,Phase 1,Phase 2
81 Diphosphonates Phase 4
82 Hydroxycholecalciferols Phase 4
83 Ibandronic acid Phase 4
84 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
85 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1
86 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1
87 Antipyretics Phase 4,Phase 2,Phase 3,Phase 1
88 Cyclooxygenase Inhibitors Phase 4,Phase 1
89 Fibrinolytic Agents Phase 4,Phase 1,Phase 2
90 Platelet Aggregation Inhibitors Phase 4,Phase 1,Phase 2
91 Adrenocorticotropic Hormone Phase 4
92 beta-endorphin Phase 4
93 Melanocyte-Stimulating Hormones Phase 4
94 Estrogens, Conjugated (USP) Phase 4,Phase 3
95 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1
96 Anti-Asthmatic Agents Phase 4,Phase 1
97 Bronchodilator Agents Phase 4
98 Phosphodiesterase 3 Inhibitors Phase 4
99 Phosphodiesterase Inhibitors Phase 4
100 Respiratory System Agents Phase 4,Phase 2,Phase 3,Phase 1
101 Vasodilator Agents Phase 4,Phase 2
102 Angiogenesis Inhibitors Phase 4,Phase 2
103 Angiogenesis Modulating Agents Phase 4,Phase 2
104 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 1,Phase 2
105 Folic Acid Antagonists Phase 4,Phase 3,Phase 2
106 Vitamin B Complex Phase 4,Phase 3,Phase 2
107 6-Mercaptopurine Phase 4,Phase 2
108 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
109 Antimitotic Agents Phase 4,Phase 2
110 Antineoplastic Agents, Phytogenic Phase 4,Phase 2
111 Ergocalciferols Phase 4,Phase 2,Phase 1
112 Antidepressive Agents Phase 4
113 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1
114 Neurotransmitter Uptake Inhibitors Phase 4
115 Psychotropic Drugs Phase 4
116
Serotonin Phase 4 50-67-9 5202
117 Serotonin Agents Phase 4
118 Serotonin Uptake Inhibitors Phase 4
119 Renal Agents Phase 4
120 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
121 Lubricant Eye Drops Phase 4
122 Omega 3 Fatty Acid Nutraceutical Phase 4,Phase 2
123 Folate Nutraceutical Phase 4,Phase 3,Phase 2
124 Vitamin B9 Nutraceutical Phase 4,Phase 3,Phase 2
125 Calciferol Nutraceutical Phase 4,Phase 2,Phase 1
126 Vitamin D2 Nutraceutical Phase 4,Phase 2,Phase 1
127
Benzocaine Approved, Investigational Phase 3,Phase 1 1994-09-7, 94-09-7 2337
128
Methotrexate Approved Phase 3,Phase 1,Phase 2 1959-05-2, 59-05-2 126941
129
Acetaminophen Approved Phase 2, Phase 3, Phase 1 103-90-2 1983
130
Diphenhydramine Approved, Investigational Phase 2, Phase 3, Phase 1 58-73-1, 147-24-0 3100