MCID: SYS011
MIFTS: 28

Systemic Lupus Erythematosus, Association with malady

Summaries for Systemic Lupus Erythematosus, Association with

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47OMIM, 33MalaCards
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MalaCards: Systemic Lupus Erythematosus, Association with is related to systemic lupus erythematosus and thrombocytopenia. An important gene associated with Systemic Lupus Erythematosus, Association with is BANK1 (B-cell scaffold protein with ankyrin repeats 1), and among its related pathways are Fcgamma receptor (FCGR) dependent phagocytosis and Phagocytosis of Microbes. The compounds Palivizumab and Intravenous Immunoglobulin have been mentioned in the context of this disorder. Related mouse phenotypes are cellular and immune system.

Description from OMIM:47 152700

Aliases & Classifications for Systemic Lupus Erythematosus, Association with

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47OMIM
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Aliases & Descriptions:

systemic lupus erythematosus, association with 47


Related Diseases for Systemic Lupus Erythematosus, Association with

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Systemic Lupus Erythematosus, Association with via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus31.6FCGR2A, FCGR3B, FCRL3, POLR3K, ITGAM, APOH
2thrombocytopenia30.7FCGR3A, FCGR2A, APOH
3nephritis30.3APOH, FCGR3B, FCGR2A, FCGR3A
4lupus nephritis30.3APOH, CD274, FCGR2A, FCGR3A
5vasculitis30.3FCGR3B, ITGAM, APOH, TNFSF4
6systemic scleroderma30.3IRF5
7tuberculosis30.3ITGAM, CALR
8klinefelter's syndrome10.5
9myelitis10.4
10transverse myelitis10.4
11pediatric systemic lupus erythematosus10.4
12prolactinoma10.2
13congenital heart block10.2
14neuromyelitis optica10.2
15erythema multiforme10.2
16papillary carcinoma10.2
17calciphylaxis10.2
18takayasu's arteritis10.2
19portal vein thrombosis10.2
20protein-losing enteropathy10.2
21autoimmune hemolytic anemia10.2
22herpes zoster10.2
23neuroleptic malignant syndrome10.2
24pernicious anemia10.2
25renal tubular acidosis10.2
26n syndrome10.2
27large cell carcinoma10.2
28arthropathy10.2
29spinocerebellar ataxia10.2
30char syndrome10.2
31sickle cell disease10.2
32wells syndrome10.2
33cardiovascular disease risk factor10.2
34ataxia10.2
35systemic lupus erythematosus 210.2
36systemic lupus erythematosus 310.2
37drug-induced lupus erythematosus10.2
38intestinal lymphangiectasia10.2
39refractory anemia10.2
40lupus erythematosus10.0APOH, CALR
41hepatitis b10.0POLR3K
42antiphospholipid syndrome10.0APOH
43myeloid leukemia10.0ITGAM
44addison's disease10.0PTPN22
45myasthenia gravis10.0FCGR2A
46sjogren's syndrome10.0POLR3K, APOH, CALR
47graves' disease10.0FCRL3, PTPN22
48myeloma10.0ITGAM
49multiple sclerosis10.0PTPN22, CD274
50psoriasis10.0PTPN22, FCGR3A

Graphical network of the top 20 diseases related to Systemic Lupus Erythematosus, Association with:



Diseases related to systemic lupus erythematosus, association with

Clinical Features for Systemic Lupus Erythematosus, Association with

Sources:
47OMIM
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Clinical features from OMIM:

152700

Drugs & Therapeutics for Systemic Lupus Erythematosus, Association with

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Systemic Lupus Erythematosus, Association with

Drug clinical trials:

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Genetic Tests for Systemic Lupus Erythematosus, Association with

Anatomical Context for Systemic Lupus Erythematosus, Association with

Animal Models for Systemic Lupus Erythematosus, Association with or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Systemic Lupus Erythematosus, Association with:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053849.9TNFSF4, IRF5, ITGAM, BANK1, TYROBP, CD274
2MP:00053879.7PTPN22, TNFSF4, IRF5, ITGAM, BANK1, TYROBP
3MP:00053979.6TNFSF4, IRF5, ITGAM, BANK1, TYROBP, CD274

Publications for Systemic Lupus Erythematosus, Association with

Genetic Variations for Systemic Lupus Erythematosus, Association with

Expression for genes affiliated with Systemic Lupus Erythematosus, Association with

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Systemic Lupus Erythematosus, Association with

Search GEO for disease gene expression data for Systemic Lupus Erythematosus, Association with.

Pathways for genes affiliated with Systemic Lupus Erythematosus, Association with

Sources:
54Reactome, 52QIAGEN, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database
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Pathways related to Systemic Lupus Erythematosus, Association with according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4FCGR3A, FCGR2A
210.3ITGAM, FCGR3B, FCGR2A
3
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10.3MS4A2, KIR2DS5, KIR2DS2
410.3TYROBP, FCGR3B, FCGR2A, FCGR3A
510.3FCGR3A, FCGR2A, FCGR3B, ITGAM
610.3ITGAM, FCGR3B, FCGR2A, FCGR3A
710.3FCGR3A, FCGR2A, FCGR3B, ITGAM
8
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10.2KIR2DS5, KIR3DS1, KIR2DS2, TYROBP
910.2CALR, ITGAM, FCGR3B, FCGR2A, FCGR3A
10
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10.2MS4A2, FCGR3A, FCGR2A, KIR2DS2, TYROBP
11
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10.1KIR2DS2, KIR3DS1, KIR2DS5, FCGR2A, FCGR3A, MS4A2
12
Hide members
10.1TYROBP, KIR2DS2, KIR2DS5, FCGR3B, FCGR3A, MS4A2
13
Hide members
10.1CALR, IRF5, ITGAM, POLR3K, TYROBP, CD274

Compounds for genes affiliated with Systemic Lupus Erythematosus, Association with

Sources:
11DrugBank, 50PharmGKB, 45Novoseek, 29IUPHAR, 24HMDB
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Compounds related to Systemic Lupus Erythematosus, Association with according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1Palivizumab1110.7FCGR3A, FCGR2A, FCGR3B
2Intravenous Immunoglobulin1110.7FCGR3B, FCGR2A, FCGR3A
3bevacizumab50 1111.7FCGR3A, FCGR2A, FCGR3B
4Ibritumomab1110.7FCGR3A, FCGR2A, FCGR3B
5alefacept45 1111.7FCGR3B, FCGR2A, FCGR3A
6Muromonab1110.7FCGR3B, FCGR2A, FCGR3A
7efalizumab45 1111.7FCGR3B, FCGR2A, FCGR3A
8tositumomab50 1111.7MS4A2, FCGR3A, FCGR2A, FCGR3B
9etanercept45 50 1112.6APOH, FCGR3B, FCGR2A, FCGR3A
10daclizumab45 1111.6FCGR3B, FCGR2A, FCGR3A
11basiliximab45 1111.6FCGR3A, FCGR2A, FCGR3B
12gemtuzumab ozogamicin45 1111.6FCGR3B, FCGR2A, FCGR3A
13natalizumab45 1111.6FCGR3B, FCGR2A, FCGR3A
14alemtuzumab45 1111.6FCGR3B, FCGR2A, FCGR3A
15rituximab45 50 1112.6FCGR3A, FCGR2A, FCGR3B, APOH
16adalimumab45 50 1112.6FCGR3B, FCGR2A, FCGR3A
17abciximab45 1111.6FCGR3B, FCGR2A, FCGR3A
18mannose4510.5CALR, APOH, ITGAM, FCGR3B, FCGR2A, FCGR3A
19cetuximab45 50 1112.5FCGR3A, FCGR2A, FCGR3B
20prednisolone45 29 1112.5FCGR2A, FCGR3B, ITGAM, APOH
21ivig4510.5FCGR3A, FCGR2A, APOH
22fmlp4510.5ITGAM, FCGR3B, FCGR2A, FCGR3A
23trastuzumab45 50 1112.4FCGR3B, FCGR2A, FCGR3A
24histidine4510.3FCGR3A, FCGR2A, POLR3K, CALR
25polysaccharide4510.3CALR, ITGAM, FCGR3B, FCGR2A
26tyrosine4510.2CALR, IRF5, ITGAM, TYROBP, FCGR3B, FCGR2A
27phosphatidylinositol4510.2FCGR3A, FCGR2A, FCGR3B, ITGAM, APOH
28cholesterol45 29 11 2413.1APOL1, APOH, ITGAM, FCGR2A, FCGR3A
29arginine459.9CALR, APOH, FCGR2A, FCGR3A, PTPN22

GO Terms for genes affiliated with Systemic Lupus Erythematosus, Association with

Sources:
16Gene Ontology
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Cellular components related to Systemic Lupus Erythematosus, Association with according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particleGO:03436410.4APOH, APOL1
2external side of plasma membraneGO:00989710.2MS4A2, FCGR3A, CD274, ITGAM, CALR
3very-low-density lipoprotein particleGO:03436110.1APOH, APOL1
4plasma membraneGO:0058869.6KIR2DS2, CD7, CD274, TYROBP, ITGAM, KIR3DS1

Biological processes related to Systemic Lupus Erythematosus, Association with according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:05077610.3FCGR3A, KIR2DS2, TYROBP
2innate immune responseGO:0450879.8MS4A2, APOL1, ITGAM, POLR3K, TYROBP, KIR2DS2
3immune responseGO:0069559.7CD274, CD7, KIR2DS2, KIR3DS1, KIR2DS5, FCGR3B

Molecular functions related to Systemic Lupus Erythematosus, Association with according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:01986410.3FCGR3A, FCGR2A, FCGR3B

Products for genes affiliated with Systemic Lupus Erythematosus, Association with

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Systemic Lupus Erythematosus, Association with

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet