MCID: SYS056
MIFTS: 13

Systemic Lupus Erythematosus with Nephritis 1

Aliases & Classifications for Systemic Lupus Erythematosus with Nephritis 1

MalaCards integrated aliases for Systemic Lupus Erythematosus with Nephritis 1:

Name: Systemic Lupus Erythematosus with Nephritis 1 54
Systemic Lupus Erythematosus with Nephritis, Susceptibility to, 1 13

External Ids:

OMIM 54 607965

Summaries for Systemic Lupus Erythematosus with Nephritis 1

MalaCards based summary : Systemic Lupus Erythematosus with Nephritis 1, is also known as systemic lupus erythematosus with nephritis, susceptibility to, 1. An important gene associated with Systemic Lupus Erythematosus with Nephritis 1 is SLEN1 (Systemic Lupus Erythematosus With Nephritis 1). The drugs Mycophenolate mofetil and Mycophenolic acid have been mentioned in the context of this disorder. Affiliated tissues include b cells, monocytes and bone.

Description from OMIM: 607965

Related Diseases for Systemic Lupus Erythematosus with Nephritis 1

Diseases in the Systemic Lupus Erythematosus with Nephritis 2 family:

Systemic Lupus Erythematosus with Nephritis 1 Systemic Lupus Erythematosus with Nephritis 3

Symptoms & Phenotypes for Systemic Lupus Erythematosus with Nephritis 1

Clinical features from OMIM:

607965

Drugs & Therapeutics for Systemic Lupus Erythematosus with Nephritis 1

Drugs for Systemic Lupus Erythematosus with Nephritis 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2 128794-94-5 5281078
2
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2 24280-93-1 446541
3
Calcitriol Approved, Nutraceutical Phase 4,Phase 2 32222-06-3 134070 5280453
4 Bone Density Conservation Agents Phase 4,Phase 2
5 Calcium, Dietary Phase 4,Phase 2
6 Micronutrients Phase 4,Phase 2
7 Trace Elements Phase 4,Phase 2
8 Vasoconstrictor Agents Phase 4,Phase 2
9 Vitamins Phase 4,Phase 2
10 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
11 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
12 Hormone Antagonists Phase 4,Phase 3,Phase 2
13 Hormones Phase 4,Phase 3,Phase 2
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
15 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Adrenocorticotropic Hormone Phase 4
17 beta-endorphin Phase 4
18 Melanocyte-Stimulating Hormones Phase 4
19
Cyclophosphamide Approved, Investigational Phase 3,Phase 1,Phase 2 50-18-0, 6055-19-2 2907
20
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
21
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
22
rituximab Approved Phase 3,Phase 2 174722-31-7 10201696
23
Azathioprine Approved Phase 2, Phase 3 446-86-6 2265
24
Prednisone Approved, Vet_approved Phase 3,Phase 2,Phase 1 53-03-2 5865
25
Infliximab Approved Phase 2, Phase 3 170277-31-3
26 Antibodies Phase 2, Phase 3,Phase 1
27 Antibodies, Monoclonal Phase 2, Phase 3,Phase 1
28 Immunoglobulins Phase 2, Phase 3,Phase 1
29 Alkylating Agents Phase 3,Phase 1,Phase 2
30 Antirheumatic Agents Phase 3,Phase 2,Phase 1
31 Antiemetics Phase 3,Phase 2
32 Anti-Inflammatory Agents Phase 3,Phase 2
33 Antineoplastic Agents, Hormonal Phase 3,Phase 2
34 Autonomic Agents Phase 3,Phase 2
35 Gastrointestinal Agents Phase 3,Phase 2
36 glucocorticoids Phase 3,Phase 2
37 Methylprednisolone acetate Phase 3,Phase 2
38 Methylprednisolone Hemisuccinate Phase 3,Phase 2
39 Neuroprotective Agents Phase 3,Phase 2
40 Peripheral Nervous System Agents Phase 3,Phase 2
41 Prednisolone acetate Phase 3,Phase 2
42 Prednisolone hemisuccinate Phase 3,Phase 2
43 Prednisolone phosphate Phase 3,Phase 2
44 Protective Agents Phase 3,Phase 2
45 Antimetabolites Phase 2, Phase 3, Phase 1
46 Antimetabolites, Antineoplastic Phase 2, Phase 3, Phase 1
47 Autoantibodies Phase 2, Phase 3
48 Dermatologic Agents Phase 2, Phase 3
49 Pharmaceutical Solutions Phase 3
50
Abatacept Approved Phase 1, Phase 2 332348-12-6 10237

Interventional clinical trials:

(show all 35)

id Name Status NCT ID Phase Drugs
1 ACTHar in the Treatment of Lupus Nephritis Recruiting NCT02226341 Phase 4 CellCept;ACTHar gel;ACTHar gel
2 The Efficacy and Safety of Calcitriol for the Treatment of Lupus Nephritis and Persistent Proteinuria Withdrawn NCT00508898 Phase 4 Calcitriol;Multivitamin
3 A Study to Evaluate Ocrelizumab in Patients With Nephritis Due to Systemic Lupus Erythematosus (BELONG) Completed NCT00626197 Phase 3 corticosteroids;cyclophosphamide;mycophenolate mofetil;ocrelizumab;placebo
4 Trial of Rituximab and Mycophenolate Mofetil Without Oral Steroids for Lupus Nephritis Suspended NCT01773616 Phase 3 Oral prednisolone;Rituximab;Mycophenolate mofetil;Methyl prednisolone
5 TNF Blockade With Remicade in Active Lupus Nephritis WHO Class V (TRIAL ) Terminated NCT00368264 Phase 2, Phase 3 infliximab;placebo
6 Study of LJP 394 in Lupus Patients With History of Renal Disease Terminated NCT00089804 Phase 3 abetimus sodium (LJP 394) and/or placebo solution;abetimus sodium (LJP 394);Phosphate-buffered saline
7 Steroids in the Maintenance of Remission of Proliferative Lupus Nephritis Withdrawn NCT00539799 Phase 3 prednisolone;Placebo
8 Five-Year Actively Controlled Clinical Trial in New Onset Juvenile Systemic Lupus Erythematosus Nephritis Withdrawn NCT00336414 Phase 3 cyclophosphamide-prednisone-azathioprine
9 Efficacy and Safety of Tacrolimus Sustained-release Capsules in Induction Phase Treatment in Lupus Nephritis Withdrawn NCT01288664 Phase 3 ADVAGRAF
10 The Effect of Calcitriol on Progress and Activity of Lupus Nephritis Unknown status NCT01863641 Phase 2 calcitriol;placebo
11 Mesenchymal Stem Cells Transplantation for Refractory Systemic Lupus Erythematosus (SLE) Unknown status NCT00698191 Phase 1, Phase 2
12 Effect of Mesenchymal Stem Cell Transplantation for Lupus Nephritis Unknown status NCT00659217 Phase 1, Phase 2
13 Phase Ib Study of SC Milatuzumab in SLE Unknown status NCT01845740 Phase 1, Phase 2 milatuzumab;Placebo
14 Laquinimod Study in Systemic Lupus Erythematosus (SLE) Patients With Active Lupus Nephritis Completed NCT01085097 Phase 2 laquinimod;Mycophenolate Mofetil;prednisolone/prednisone;Placebo
15 Treating Systemic Lupus Erythematosus (SLE) Patients With CTLA4-IgG4m (RG2077) Completed NCT00094380 Phase 1, Phase 2 CTLA4-IgG4m (RG2077);Cyclophosphamide
16 Can Targeted Elimination of B-cell Depletion Therapy and/or Combination Therapy on Systemic Lupus Erythematosus Completed NCT00556192 Phase 2 rituximab
17 Etanercept for the Treatment of Lupus Nephritis Terminated NCT00447265 Phase 2 Etanercept;Lupus Treatment- Standard of Care;Placebo
18 Lupus Immunosuppressive/Immunomodulatory Therapy or Stem Cell Transplant (LIST) Withdrawn NCT00230035 Phase 2 Rabbit anti-thymocyte globulin;Methylprednisolone;Growth colony stimulating factor (G-CSF);Corticosteroids;Mycophenolate mofetil;Azathioprine;Intravenous immunoglobulin;Methotrexate;Rituximab;Leflunomide
19 Safety Study of AMG 811 in Subjects With Systemic Lupus Erythematosus With and Without Glomerulonephritis Completed NCT00818948 Phase 1 AMG 811
20 Cyclophosphamide and Fludarabine to Treat Lupus Nephritis Completed NCT00001676 Phase 1 SQ Fludarabine
21 Humanized LL2IGG to Treat Systemic Lupus Erythematosus Completed NCT00011908 Phase 1 hLL2 (Epratuzumab)
22 Phase I Study in China - Tolerability of a Single Dose of Abatacept 30 mg/kg Completed NCT00705367 Phase 1 Placebo;Abatacept;Abatacept
23 Monoclonal Antibody Treatment for Systemic Lupus Erythematosus Completed NCT00046774 Phase 1 MRA 003 US
24 Evaluate the Safety of CS20AT04 Inj. in Subjects With Lupus Nephritis Enrolling by invitation NCT03174587 Phase 1
25 Safety Study of Anti-Macrophage Migration Inhibitory Factor (Anti-MIF) Antibody in Lupus Nephritis Terminated NCT01541670 Phase 1 Anti-Macrophage Migration Inhibitory Factor (Anti-MIF) Antibody
26 Nonmyeloablative Allo Stem Cell Transplant for Severe Autoimmune Diseases Terminated NCT00849745 Phase 1
27 Study of TRU-015 in Subjects With Membranous Nephropathy Secondary to Systemic Lupus Erythematosus Terminated NCT00479622 Phase 1 TRU-015
28 Anti-ficolin-3 Autoantibodies in Lupus Nephritis Completed NCT02625831
29 Anti-ficolin-2 Autoantibodies in Lupus Nephritis Completed NCT03063281
30 Prediction of Outcome of Lupus Nephritis Recruiting NCT02403115
31 Dynamic Imaging of Variation in Lupus Nephritis Recruiting NCT03180021
32 Study of Systemic Lupus Erythematosus Recruiting NCT00001372
33 SSerum/Urinary Monocyte Chemoattractant Protein-1 Level as a Marker for Lupus Nephritis Not yet recruiting NCT03164720
34 Detection of Annexin A2 in Systemic Lupus Erythematosus Not yet recruiting NCT03031925
35 Study of the Role of Soluble Forms of RAGE (sRAGE/esRAGE) as Diagnostic and Prognostic Biomarkers of Systemic Lupus Erythematosus. Not yet recruiting NCT02891213

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Anatomical Context for Systemic Lupus Erythematosus with Nephritis 1

MalaCards organs/tissues related to Systemic Lupus Erythematosus with Nephritis 1:

39
B Cells, Monocytes, Bone

Publications for Systemic Lupus Erythematosus with Nephritis 1

Variations for Systemic Lupus Erythematosus with Nephritis 1

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Sources for Systemic Lupus Erythematosus with Nephritis 1

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