MCID: SYS039
MIFTS: 19

Systemic Lupus Erythematous, Association with 6

Categories: Genetic diseases

Aliases & Classifications for Systemic Lupus Erythematous, Association with 6

MalaCards integrated aliases for Systemic Lupus Erythematous, Association with 6:

Name: Systemic Lupus Erythematous, Association with 6 54
Systemic Lupus Erythematosus 6 71 29
Sleb6 71

Characteristics:

HPO:

32
systemic lupus erythematous, association with 6:
Inheritance polygenic inheritance


Classifications:



External Ids:

OMIM 54 609939
MedGen 40 C1835919
MeSH 42 D008180
SNOMED-CT via HPO 65 55464009

Summaries for Systemic Lupus Erythematous, Association with 6

UniProtKB/Swiss-Prot : 71 Systemic lupus erythematosus 6: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

MalaCards based summary : Systemic Lupus Erythematous, Association with 6, also known as systemic lupus erythematosus 6, is related to itgam-related susceptibility to systemic lupus erythematosus, and has symptoms including systemic lupus erythematosus An important gene associated with Systemic Lupus Erythematous, Association with 6 is ITGAM (Integrin Subunit Alpha M). The drugs Everolimus and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and bone.

Description from OMIM: 609939

Related Diseases for Systemic Lupus Erythematous, Association with 6

Diseases related to Systemic Lupus Erythematous, Association with 6 via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 itgam-related susceptibility to systemic lupus erythematosus 10.8

Symptoms & Phenotypes for Systemic Lupus Erythematous, Association with 6

Clinical features from OMIM:

609939

Human phenotypes related to Systemic Lupus Erythematous, Association with 6:

32
id Description HPO Frequency HPO Source Accession
1 systemic lupus erythematosus 32 HP:0002725

Drugs & Therapeutics for Systemic Lupus Erythematous, Association with 6

Drugs for Systemic Lupus Erythematous, Association with 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 4 159351-69-6 6442177
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4
Mycophenolate mofetil Approved, Investigational Phase 4 128794-94-5 5281078
5
Mycophenolic acid Approved Phase 4 24280-93-1 446541
6
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
7
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
8
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
9
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
10 Anti-Bacterial Agents Phase 4
11 Antibiotics, Antitubercular Phase 4
12 Antiemetics Phase 4
13 Antifungal Agents Phase 4
14 Anti-Infective Agents Phase 4
15 Anti-Inflammatory Agents Phase 4
16 Antineoplastic Agents, Hormonal Phase 4
17 Autonomic Agents Phase 4
18 Calcineurin Inhibitors Phase 4
19 Gastrointestinal Agents Phase 4
20 glucocorticoids Phase 4
21 Hormone Antagonists Phase 4
22 Hormones Phase 4
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
24 Immunosuppressive Agents Phase 4
25 Methylprednisolone acetate Phase 4
26 Methylprednisolone Hemisuccinate Phase 4
27 Neuroprotective Agents Phase 4
28 Peripheral Nervous System Agents Phase 4
29 Prednisolone acetate Phase 4
30 Prednisolone hemisuccinate Phase 4
31 Prednisolone phosphate Phase 4
32 Protective Agents Phase 4
33
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
34 Antioxidants Phase 2
35 triamcinolone acetonide Phase 2
36 Triamcinolone diacetate Phase 2
37 Triamcinolone hexacetonide Phase 2
38 Tea Nutraceutical Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Everolimus + Very Low Tacrolimus vs Enteric-coated Mycophenolate Sodium + Low Tacrolimus in de Novo Renal Transplant Unknown status NCT02084446 Phase 4 Everolimus;Very Low Tacrolimus;Low Tacrolimus;Steroids;Thymoglobulin;Sodium Mycophenolate
2 Effect of Green Tea on Treatment of Lupus Completed NCT02875691 Phase 2
3 Molecular Mechanisms Characteristics in Systemic Lupus Erythematous Autoimmune Disease Withdrawn NCT02270710

Search NIH Clinical Center for Systemic Lupus Erythematous, Association with 6

Genetic Tests for Systemic Lupus Erythematous, Association with 6

Genetic tests related to Systemic Lupus Erythematous, Association with 6:

id Genetic test Affiliating Genes
1 Systemic Lupus Erythematosus 6 29

Anatomical Context for Systemic Lupus Erythematous, Association with 6

MalaCards organs/tissues related to Systemic Lupus Erythematous, Association with 6:

39
Skin, Kidney, Bone, Bone Marrow

Publications for Systemic Lupus Erythematous, Association with 6

Variations for Systemic Lupus Erythematous, Association with 6

Expression for Systemic Lupus Erythematous, Association with 6

Search GEO for disease gene expression data for Systemic Lupus Erythematous, Association with 6.

Pathways for Systemic Lupus Erythematous, Association with 6

GO Terms for Systemic Lupus Erythematous, Association with 6

Sources for Systemic Lupus Erythematous, Association with 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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