SMCD
MCID: SYS004
MIFTS: 65

Systemic Mastocytosis (SMCD) malady

Blood, Cancer categories

Summaries for Systemic Mastocytosis

Sources:
43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Systemic mastocytosis is a condition caused by the accumulation of mast cells in more than one part of the body. mast cells contain substances such as histamine that regulate allergic reactions. in systemic mastocytosis, mast cells may build up in the bone marrow, internal organs, or in the skin. this condition is usually diagnosed in adults. treatment is generally based on a person's symptoms, but it may include antihistamines (to prevent the effect of mast cell histamine) or chemotherapy for more aggressive forms.there are several different types of systemic mastocytosis. indolent systemic mastocytosis develops slowly, while aggressive systemic mastocytosis develops more rapidly. another form, called systemic mastocytosis with associated hemotologic non-mast cell lineage disease (sm-ahnmd), is characterized by the presence of several types of blood disorders. mast cell leukemia is a rare form of systemic mastocytosis. last updated: 10/5/2012

MalaCards: Systemic Mastocytosis, also known as mast cell leukemia, is related to mastocytosis and indolent systemic mastocytosis, and has symptoms including urticaria, nausea/vomiting/regurgitation/merycism/hyperemesis and acute abdominal pain/colic. An important gene associated with Systemic Mastocytosis is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Regulation of KIT signaling and Bisphosphonate Pathway, Pharmacodynamics. The compounds cycloheximide and monochloroacetic acid have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and spleen, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Aliases & Classifications for Systemic Mastocytosis

Sources:
43NIH Rare Diseases, 61UMLS, 10DISEASES, 8Disease Ontology, 49Orphanet, 31LifeMap Discovery™, 22GTR, 45Novoseek, 57SNOMED-CT, 40NCIt, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood


Characteristics (Orphanet epidemiological data):

49
systemic mastocytosis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age
mast cell leukemia:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Variable


Aliases & Descriptions:

systemic mastocytosis 8 43 10 49 31
mast cell leukemia 43 22 49
indolent systemic mastocytosis 43 61
corneal dystrophy, subepithelial mucinous 61
systemic tissue mast cell disease 8
smcd - systemic mast cell disease 8
agressive systemic mastocytosis 43
systemic mast cell disease 43
mastocytosis, systemic 61
mastocytosis systemic 45
leukemia, mast-cell 61
mast-cell leukemia 10
leukemia mast cell 45
mast cell disease 49
smcd 43


External Ids:

Disease Ontology8 DOID:349
NCIt40 C9235
MeSH35 D034721
MESH via Orphanet36 D034721, D007946
ICD10 via Orphanet26 C96.2, C94.3
SNOMED-CT via Orphanet58 397016004, 110002002, 128924002
UMLS via Orphanet62 C0221013, C0023461

Related Diseases for Systemic Mastocytosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Systemic Mastocytosis family:

mastocytosis systemic mastocytosis with an associated clonal hematologic non-mast cell lineage disease

Diseases related to Systemic Mastocytosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1mastocytosis32.0PDGFRA, IFNA2, HDC, CHIC2, TPSAB1, KIT
2indolent systemic mastocytosis31.1ISM1
3acute leukemia30.9ITGAX, STAT5A, KITLG, KIT
4acute myeloid leukemia30.8KIT, CHIC2
5mast-cell leukemia30.8KIT, KITLG
6urticaria30.7FCER2
7urticaria pigmentosa30.7KIT, KITLG
8chronic myelomonocytic leukemia30.4STAT5A, PDGFRA, KIT, KITLG
9sm-ahnmd30.3ENPP3
10hypereosinophilic syndrome30.3KIT, PDGFRA
11myeloproliferative disorder30.2STAT5A, KITLG, IFNA2, PDGFRA, KIT
12splenomegaly30.0IL2RA, IFNA2, ITGAX
13thrombocytosis30.0IFNA2, KITLG, TET2
14asthma30.0HDC, FCER2, KITLG, IL2RA, STAT5A
15myelodysplastic syndromes30.0PDGFRA, KIT, KITLG, STAT5A, NRAS
16carcinoid syndrome30.0IFNA2, HDC, SLC18A1
17aggressive systemic mastocytosis10.7
18mast syndrome10.6
19osteoporosis10.6
20smouldering systemic mastocytosis10.4
21portal hypertension10.3
22splenic disease10.3
23classic mast cell leukemia10.3
24bone fracture10.2
25syncope10.2
26microphthalmia10.2
27subepithelial mucinous corneal dystrophy10.2
28mast-cell sarcoma10.2
29n syndrome10.2
30t-cell leukemia10.2
31headache10.2
32isolated bone marrow mastocytosis10.2
33systemic mastocytosis with an associated clonal hematologic non-mast cell lineage disease10.2
34osteopetrosis10.2
35splenic infarction10.2
36malignant germ cell tumor10.2
37ovarian germ cell tumor10.2
38mixed germ cell tumor10.2
39ovarian germ cell malignant tumor10.2
40back pain10.1
41acute basophilic leukemia10.1
42felty's syndrome10.0
43osteoporotic fracture10.0
44intrahepatic cholestasis10.0
45secretory diarrhea10.0
46renal clear cell carcinoma10.0
47acute t cell leukemia10.0
48pinguecula10.0
49diffuse cutaneous mastocytosis10.0
50gastric lymphoma10.0

Graphical network of the top 20 diseases related to Systemic Mastocytosis:



Diseases related to systemic mastocytosis

Clinical Features for Systemic Mastocytosis

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 34)
  • urticaria
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • malabsorption/chronic diarrhea/steatorrhea
  • facial pain/cephalalgia/migraine
  • severe allergic reaction/atopy
  • anomalies of the hematological system
  • eosinophils anomalies/hypereosinophilia
  • mastocytosis
  • cutaneous rash
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • osteosclerosis/osteopetrosis/bone condensation
  • anaemia
  • leukopenia/hypoleukocytosis
  • thrombocytopenia/thrombopenia
  • hot flushes/sensation of cold
  • ascitis
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • cirrhosis
  • hepatomegaly/liver enlargement (excluding storage disease)
  • portal hypertension
  • splenomegaly
  • asthma/bronchospasm
  • cardiac rhythm disorder/arrhythmia
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • lymphadenopathy/polyadenopathies
  • myalgia/muscular pain
  • mutiple fractures/bone fragility
  • osteolysis/osteoclasia/bone destruction/erosions
  • bone pain
  • articular/joint pain/arthralgia
  • bone marrow failure/pancytopenia
  • acute leukemia
  • myeloproliferative syndrome/chronic leukemia

Drugs & Therapeutics for Systemic Mastocytosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Systemic Mastocytosis

Drug clinical trials:

Search ClinicalTrials for Systemic Mastocytosis

Search NIH Clinical Center for Systemic Mastocytosis

Search CenterWatch for Systemic Mastocytosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Systemic Mastocytosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Systemic Mastocytosis:
Peripheral blood-derived hematopoietic stem cells for treatment of systemic mastocytosis
Embryonic/Adult Cultured Cells Related to Systemic Mastocytosis:
Peripheral blood-derived hematopoietic stem cells (family), PMID: 10498605

Genetic Tests for Systemic Mastocytosis

Sources:
22GTR
See all sources

Genetic tests related to Systemic Mastocytosis:

id Genetic test Affiliating Genes
1 Mast Cell Leukemia22

Anatomical Context for Systemic Mastocytosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Systemic Mastocytosis:

33
Bone marrow, Lymph node, Spleen, Brain, Heart, Small intestine, Liver, Lung, Breast, Skin, Ovary, Myeloid, T cells, B lymphoblasts, B cells

Animal Models for Systemic Mastocytosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Systemic Mastocytosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.9TET2, KIT, KITLG, NRAS, STAT5A, PDGFRA
2MP:00030129.5PDGFRA, ITGAX, HDC, NRAS, CD5, TET2
3MP:00028739.4TET2, PDGFRA, SLC18A1, KIT, CD2, CD5
4MP:00053979.3MS4A1, TET2, STAT5A, FCER2, RAC2, KITLG
5MP:00053879.2CD5, NRAS, HDC, PDGFRA, STAT5A, IL2RA
6MP:00053849.2IL2RA, MS4A1, TET2, SLC18A1, FCER2, RAC2

Publications for Systemic Mastocytosis

Sources:
51PubMed
See all sources

Articles related to Systemic Mastocytosis:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
Guidelines and diagnostic algorithm for patients with suspected systemic mastocytosis: a proposal of the Austrian competence network (AUCNM). (23675567)
2013
2
Advanced systemic mastocytosis: the impact of KIT mutations in diagnosis, treatment, and progression. (23181448)
2013
3
Telangiectasic mastocytosis with systemic sclerosis. (23237785)
2013
4
Flow cytometry criteria for systemic mastocytosis: bone marrow mast cell counts do not always count. (23547320)
2013
5
Munchausen's syndrome with rare hematological disorder, systemic mastocytosis: a case report. (24026737)
2013
6
Systemic mastocytosis associated with childhood acute myeloid leukemia. (22584780)
2013
7
Severe life-threatening or disabling anaphylaxis in patients with systemic mastocytosis: a single-center experience. (22123213)
2012
8
Systemic mastocytosis with associated clonal hematological non-mast-cell lineage disease: a case review. (22081475)
2012
9
Adult-onset systemic mastocytosis in monozygotic twins with KIT D816V and JAK2 V617F mutations. (22608575)
2012
10
Systemic mastocytosis associated with splenic marginal zone lymphoma with villous lymphocytes. (21785582)
2011
11
Aggressive systemic mastocytosis associated with mesangioproliferative glomerulonephritis. (21196717)
2011
12
Imatinib mesylate for aggressive systemic mastocytosis with long bone osteolysis. (21679828)
2011
13
Nodularity of the small intestine in a child with systemic mastocytosis associated with hyperimmunoglobulin M syndrome. (21865968)
2011
14
Mast cells from different molecular and prognostic subtypes of systemic mastocytosis display distinct immunophenotypes. (20061010)
2010
15
Gastrointestinal involvement and manifestations in systemic mastocytosis. (20162539)
2010
16
Myelomastocytic leukemia versus mast cell leukemia versus systemic mastocytosis associated with acute myeloid leukemia: a diagnostic challenge. (20658589)
2010
17
How I treat patients with advanced systemic mastocytosis. (20855864)
2010
18
Variable presence of KITD816V in clonal haematological non-mast cell lineage diseases associated with systemic mastocytosis (SM-AHNMD). (20112369)
2010
19
Utility of the World Heath Organization classification criteria for the diagnosis of systemic mastocytosis in bone marrow. (19116630)
2009
20
Systemic mastocytosis presenting as osteoporosis--a case report. (19305945)
2009
21
The stromal composition of mast cell aggregates in systemic mastocytosis. (19396155)
2009
22
Refractory Noninfectious Anterior Uveitis Associated With Systemic Mastocytosis. (19791718)
2009
23
Recent-onset bronchial asthma as a manifestation of systemic mastocytosis. (20128434)
2009
24
Systemic mastocytosis with plasma cell dyscrasia: report of a case. (18061667)
2008
25
Systemic mastocytosis with acute myelomonocytic leukemia: a case report. (23100960)
2008
26
Two patients with osteoporosis: initial presentation of systemic mastocytosis. (18301978)
2008
27
Biochemical markers predictive for bone marrow involvement in systemic mastocytosis. (18166795)
2008
28
Imaging of systemic mastocytosis by FDG-PET/CT demonstrates increased activity in cortical bone. (18287854)
2008
29
The origin of neoplastic mast cells in systemic mastocytosis with AML1/ETO-positive acute myeloid leukemia. (17976525)
2007
30
Systemic mastocytosis simulating osseous metastatic disease. (17222193)
2007
31
Isolated lymphadenopathy as the first presentation of systemic mastocytosis--description of two cases]. (16506600)
2006
32
Treatment of systemic mastocytosis. (16931293)
2006
33
Systemic mastocytosis (SM) associated with chronic eosinophilic leukemia (SM-CEL): detection of FIP1L1/PDGFRalpha, classification by WHO criteria, and response to therapy with imatinib. (16406018)
2006
34
Aggressive systemic mastocytosis: a case report and brief review of the literature. (15794480)
2005
35
The faces of mast cell disease: bone marrow infiltrates in 3 patients with systemic mastocytosis. (15806514)
2005
36
Systemic mastocytosis masquerading as metastatic breast carcinoma. (16163260)
2004
37
Systemic mastocytosis associated with acute myeloid leukemia: case report and implications for disease pathogenesis. (15241340)
2004
38
Multiple life-threatening fainting episodes: fatal systemic mastocytosis. (14719479)
2003
39
Cytogenetic and molecular genetic abnormalities in systemic mastocytosis. (11919394)
2002
40
Systemic mastocytosis. (12443644)
2002
41
Systemic mastocytosis with involvement of the pelvis: a radiographic and clinicopathologic study--a case report. (10631902)
1999
42
Response of severe systemic mastocytosis to interferon alpha. (9580806)
1998
43
Systemic mastocytosis and skeletal lesions. (10213578)
1997
44
Trisomies 9 and 8 detected by fluorescence in situ hybridization in patients with systemic mastocytosis. (8765835)
1996
45
Long-term response to interferon-alpha in a patient with systemic mastocytosis and chronic myelomonocytic leukemia. (8042625)
1994
46
Effects of tixocortol pivalate on gastrointestinal disease in systemic mastocytosis: a preliminary study. (2043986)
1991
47
Case report 412: Systemic mastocytosis. (3576252)
1987
48
The bone marrow in urticaria pigmentosa and systemic mastocytosis. Cell composition and mast cell density in relation to urinary excretion of tele-methylimidazoleacetic acid. (3954410)
1986
49
Disodium cromoglycate in the treatment of systemic mastocytosis involving only bone. (3937412)
1985
50
Systemic mastocytosis: case report and literature review. (6737504)
1984

Genetic Variations for Systemic Mastocytosis

Expression for genes affiliated with Systemic Mastocytosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Systemic Mastocytosis

Search GEO for disease gene expression data for Systemic Mastocytosis.

Pathways for genes affiliated with Systemic Mastocytosis

Sources:
54Reactome, 50PharmGKB, 38NCBI BioSystems Database, 60Tocris Bioscience, 52QIAGEN, 4Cell Signaling Technology, 30KEGG, 12EMD Millipore
See all sources

Pathways related to Systemic Mastocytosis according to GeneCards/GeneDecks:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3KIT, KITLG
210.2NRAS, RAC2
310.2KITLG, NRAS, KIT
4
Hide members
10.2STAT5A, KITLG, KIT
5
Hide members
10.2KIT, NRAS, PDGFRA
6
Hide members
10.2ITGAX, CD2, IL2RA
7
Hide members
10.1IL2RA, NRAS, STAT5A
810.1NRAS, ITGAX, CD2
910.1STAT5A, RAC2, FCER2
1010.1FCER2, ITGAX, RAC2
1110.1KITLG, KIT, IL2RA, PDGFRA
12
Hide members
10.1RAC2, STAT5A, NRAS
1310.1ITGAX, NRAS, RAC2
14
Hide members
10.1PDGFRA, NRAS, KITLG, KIT
15
Hide members
10.1KIT, PDGFRA, KITLG, NRAS
16
Hide members
10.1IFNA2, STAT5A, IL2RA, NRAS
17
Hide members
10.1IFNA2, NRAS, RAC2, FCER2
18
Hide members
10.1IFNA2, CD2, NRAS, ITGAX
19
Hide members
10.0PDGFRA, ITGAX, KIT, RAC2
20
Hide members
10.0KIT, NRAS, STAT5A, RAC2
21
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10.0IL2RA, FCER2, NRAS, STAT5A
2210.0PDGFRA, NRAS, STAT5A, IL2RA
23
Hide members
10.0STAT5A, NRAS, RAC2, PDGFRA
24
Hide members
10.0PDGFRA, ITGAX, NRAS, RAC2
25
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10.0PDGFRA, ITGAX, NRAS, RAC2
26
Hide members
10.0ITGAX, NRAS, RAC2, PDGFRA
27
Hide members
10.0PDGFRA, KIT, KITLG, NRAS, IL2RA
28
Hide members
10.0ITGAX, RAC2, STAT5A, NRAS
29
Hide members
10.0NRAS, STAT5A, PDGFRA, KIT, KITLG
30
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10.0KIT, KITLG, NRAS, STAT5A, PDGFRA
319.9NRAS, KIT, KITLG, IL2RA, IFNA2, PDGFRA
32
Hide members
9.9RAC2, KIT, KITLG, IL2RA, NRAS, PDGFRA
33
Hide members
9.9RAC2, KIT, PDGFRA, NRAS, IL2RA, KITLG
34
Hide members
9.9PDGFRA, STAT5A, NRAS, CD2, KIT, IL2RA
359.9PDGFRA, STAT5A, NRAS, KITLG, KIT, RAC2
369.9MS4A1, CD5, CD2, IL2RA, FCER2, KIT
37
Hide members
9.8PDGFRA, IL2RA, NRAS, CD2, KITLG, KIT
38
Hide members
9.8PDGFRA, ITGAX, NRAS, IL2RA, KITLG, KIT
39
Hide members
9.8PDGFRA, RAC2, KIT, KITLG, IL2RA, NRAS
40
Hide members
9.6KIT, RAC2, KITLG, PDGFRA, STAT5A, NRAS
41
Hide members
9.6ITGAX, PDGFRA, KIT, RAC2, KITLG, IL2RA
42
Hide members
9.6KIT, STAT5A, RAC2, CD2, KITLG, IL2RA
43
Hide members
9.5KIT, FCER2, KITLG, RAC2, IL2RA, NRAS

Compounds for genes affiliated with Systemic Mastocytosis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB
See all sources

Compounds related to Systemic Mastocytosis according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.7ITGAX
2monochloroacetic acid4510.6KIT, KITLG
3mizoribine4510.6IL2RA, IFNA2
4su54164510.6KITLG, KIT, STAT5A
5con a4510.6IFNA2, IL2RA, CD2
6pkc 4124510.6KIT, PDGFRA, STAT5A
7aspartate4510.6PDGFRA, STAT5A, HDC
8hydroxyurea45 50 1112.5PDGFRA, IFNA2, KIT, KITLG
9ag-12964510.5PDGFRA, STAT5A, KIT, KITLG
10gp 1304510.5STAT5A, IL2RA, KITLG, KIT
11cytarabine45 50 1112.5STAT5A, KITLG, KIT, IFNA2
12cyclophosphamide45 50 1112.5MS4A1, KITLG, IFNA2, IL2RA
13pentostatin45 60 29 1113.5IFNA2, IL2RA
14hydroxychloroquine45 1111.5IFNA2, IL2RA
15ifn-alpha4510.5IL2RA, STAT5A, IFNA2
16herbimycin a45 6011.4KITLG, IL2RA, STAT5A, FCER2
17imatinib45 50 1112.4STAT5A, KITLG, PDGFRA, KIT
18neopterin4510.4IL2RA, FCER2, IFNA2
19megestrol acetate4510.4IFNA2, IL2RA
20ionomycin4510.4STAT5A, CD2, FCER2, IL2RA
21calcitriol45 60 11 2413.4IL2RA, PDGFRA, KITLG, FCER2
22rituximab45 50 1112.4IFNA2, MS4A1, IL2RA
23doxorubicin45 50 1112.4KIT, RAC2, KITLG, IL2RA, IFNA2
245fluorouracil4510.4IFNA2, IL2RA, KIT, KITLG
25toluidine4510.4KITLG, KIT
26rapamycin4510.4STAT5A, KITLG, IL2RA, KIT, PDGFRA
27fmlp4510.3RAC2, FCER2, ITGAX, STAT5A
28agar4510.3STAT5A, KITLG, NRAS, IFNA2
29Pazopanib1110.3KIT, PDGFRA
30paraffin4510.3MS4A1, PDGFRA, CD5, IL2RA, KITLG, KIT
31superoxide45 2411.2FCER2, RAC2, IFNA2, ITGAX, KITLG
32vegf4510.2STAT5A, IL2RA, KITLG, IFNA2, PDGFRA, KIT
33vincristine45 50 1112.2KIT, IFNA2, IL2RA
34phosphatidylinositol4510.2RAC2, KIT, PDGFRA, STAT5A, IL2RA, KITLG
35thymidine45 2411.1KITLG, PDGFRA, IFNA2, FCER2, KIT, IL2RA
36histamine45 29 2412.1IFNA2, HDC, IL2RA, KIT, FCER2, ENPP3
37retinoic acid45 2411.1STAT5A, ITGAX, HDC, KITLG, KIT, PDGFRA
38steroid459.9IL2RA, STAT5A, KIT, IFNA2, KITLG
39calcium45 50 11 2412.9KITLG, FCER2, PDGFRA, MS4A1, STAT5A, HDC
40wortmannin459.7STAT5A, ENPP3, KITLG, CD2
41tyrosine459.6SLC18A1, NRAS, FCER2, RAC2, KIT, IFNA2

GO Terms for genes affiliated with Systemic Mastocytosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Systemic Mastocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.9PDGFRA, CD2, FCER2, MS4A1, ENPP3, CD5
2external side of plasma membraneGO:0098979.7PDGFRA, MS4A1, FCER2, KIT, IL2RA, CD2
3extracellular regionGO:0055769.4ENPP3, KITLG, CD2, ISM1, IFNA2, FCER2
4plasma membraneGO:0058869.2PDGFRA, ITGAX, NRAS, CHIC2, CD5, CD2

Biological processes related to Systemic Mastocytosis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1germ cell programmed cell deathGO:03523410.6KIT, KITLG
2negative regulation of mast cell apoptotic processGO:03302610.5KITLG, STAT5A
3positive regulation of mast cell proliferationGO:07066810.5KITLG, STAT5A
4luteinizationGO:00155310.4PDGFRA, STAT5A
5positive regulation of phospholipase C activityGO:01086310.4KIT, PDGFRA
6peptidyl-tyrosine phosphorylationGO:01810810.3KIT, STAT5A, PDGFRA
7fibroblast growth factor receptor signaling pathwayGO:00854310.3PDGFRA, NRAS, KITLG, KIT
8Fc-epsilon receptor signaling pathwayGO:03809510.3PDGFRA, NRAS, KITLG, KIT
9epidermal growth factor receptor signaling pathwayGO:00717310.2PDGFRA, NRAS, KITLG, KIT
10leukocyte migrationGO:05090010.1CD2, NRAS, ITGAX
11neurotrophin TRK receptor signaling pathwayGO:04801110.0PDGFRA, NRAS, KITLG, KIT
12blood coagulationGO:0075969.9IFNA2, ITGAX, NRAS, CD2, RAC2
13innate immune responseGO:0450879.7IFNA2, PDGFRA, NRAS, KITLG, KIT

Products for genes affiliated with Systemic Mastocytosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Systemic Mastocytosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet