SMCD
MCID: SYS004
MIFTS: 70

Systemic Mastocytosis (SMCD) malady

Blood diseases, Cancer diseases categories

Summaries for Systemic Mastocytosis

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Systemic mastocytosis is a condition caused by the accumulation of mast cells in more than one part of the body. mast cells contain substances such as histamine that regulate allergic reactions. in systemic mastocytosis, mast cells may build up in the bone marrow, internal organs, or in the skin. this condition is usually diagnosed in adults. treatment is generally based on a person's symptoms, but it may include antihistamines (to prevent the effect of mast cell histamine) or chemotherapy for more aggressive forms.there are several different types of systemic mastocytosis. indolent systemic mastocytosis develops slowly, while aggressive systemic mastocytosis develops more rapidly. another form, called systemic mastocytosis with associated hemotologic non-mast cell lineage disease (sm-ahnmd), is characterized by the presence of several types of blood disorders. mast cell leukemia is a rare form of systemic mastocytosis. last updated: 10/5/2012

MalaCards: Systemic Mastocytosis, also known as mast cell leukemia, is related to indolent systemic mastocytosis and leukemia, and has symptoms including mutiple fractures/bone fragility, osteolysis/osteoclasia/bone destruction/erosions and bone pain. An important gene associated with Systemic Mastocytosis is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Regulation of KIT signaling and Bisphosphonate Pathway, Pharmacodynamics. The compounds cycloheximide and monochloroacetic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and skin, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Aliases & Classifications for Systemic Mastocytosis

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42NIH Rare Diseases, 60UMLS, 10DISEASES, 8Disease Ontology, 48Orphanet, 30LifeMap Discovery™, 22GTR, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
systemic mastocytosis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age
mast cell leukemia:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Variable


Aliases & Descriptions:

systemic mastocytosis 8 42 10 48 30
mast cell leukemia 42 22 48
indolent systemic mastocytosis 42 60
corneal dystrophy, subepithelial mucinous 60
systemic tissue mast cell disease 8
smcd - systemic mast cell disease 8
agressive systemic mastocytosis 42
systemic mast cell disease 42
mastocytosis, systemic 60
mastocytosis systemic 44
leukemia, mast-cell 60
mast-cell leukemia 10
leukemia mast cell 44
mast cell disease 48
smcd 42


External Ids:

Disease Ontology8 DOID:349
NCIt39 C9235
MeSH34 D034721
MESH via Orphanet35 D034721, D007946
ICD10 via Orphanet26 C96.2, C94.3
SNOMED-CT via Orphanet57 397016004, 110002002, 128924002
UMLS via Orphanet61 C0221013, C0023461

Related Diseases for Systemic Mastocytosis

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17GeneCards, 18GeneDecks
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Diseases in the Systemic Mastocytosis family:

Mastocytosis

Diseases related to Systemic Mastocytosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1indolent systemic mastocytosis31.1ISM1
2leukemia31.1STAT5A, CD5, ITGAX, KITLG, KIT, FCER2
3acute leukemia30.8ITGAX, STAT5A, KITLG, KIT
4myeloid leukemia30.8STAT5A, KITLG, KIT
5acute myeloid leukemia30.8KIT, CHIC2
6mast-cell leukemia30.7KIT, KITLG
7urticaria30.7FCER2
8urticaria pigmentosa30.7KIT, KITLG
9sm-ahnmd30.6ENPP3
10eosinophilia30.4FCER2, IL2RA, CD2, CHIC2, PDGFRA, IFNA2
11myeloma30.4STAT5A, IFNA2, FCER2, KITLG
12mast cell neoplasm30.3KIT, KITLG, HDC
13myelofibrosis30.3KIT, STAT5A
14pancreatitis30.1KITLG, NRAS
15sarcoma30.1NRAS, FCER2, KIT, KITLG, PDGFRA
16chronic lymphocytic leukemia30.1MS4A1, FCER2, IL2RA, CD5, HDC
17mastocytosis30.1PDGFRA, IFNA2, HDC, CHIC2, TPSAB1, KIT
18hepatitis29.9IFNA2
19nephrotic syndrome29.9IL2RA
20thrombocytosis29.9IFNA2, KITLG, TET2
21asthma29.9HDC, FCER2, KITLG, IL2RA, STAT5A
22melanoma29.9IFNA2, HDC, KIT, STAT5A, KITLG, CD2
23aggressive systemic mastocytosis10.7
24osteoporosis10.5
25cutaneous mastocytosis10.4
26gastrointestinal system disease10.3
27splenic disease10.3
28portal hypertension10.3
29hypertension10.3
30classic mast cell leukemia10.2
31aleukemic mast cell leukemia10.2
32bone fracture10.2
33diarrhea10.2
34subepithelial mucinous corneal dystrophy10.2
35microphthalmia10.2
36osteopetrosis10.1
37splenic infarction10.1
38ovarian disease10.1
39mast-cell sarcoma10.1
40cholangitis10.1
41cholestasis10.1
42disseminated intravascular coagulation10.1
43histiocytosis10.1
44inflammatory bowel disease10.1
45smouldering systemic mastocytosis10.1
46systemic mastocytosis with an associated clonal hematologic non-mast cell lineage disease10.1
47monocytic leukemia10.1
48felty's syndrome10.0
49liver cirrhosis10.0
50liver disease10.0

Graphical network of the top 20 diseases related to Systemic Mastocytosis:



Diseases related to systemic mastocytosis

Clinical Features for Systemic Mastocytosis

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48Orphanet
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Symptoms:

48 (show all 34)
  • mutiple fractures/bone fragility
  • osteolysis/osteoclasia/bone destruction/erosions
  • bone pain
  • articular/joint pain/arthralgia
  • bone marrow failure/pancytopenia
  • acute leukemia
  • myeloproliferative syndrome/chronic leukemia
  • anomalies of the hematological system
  • myalgia/muscular pain
  • lymphadenopathy/polyadenopathies
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • osteosclerosis/osteopetrosis/bone condensation
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • cutaneous rash
  • mastocytosis
  • eosinophils anomalies/hypereosinophilia
  • severe allergic reaction/atopy
  • facial pain/cephalalgia/migraine
  • malabsorption/chronic diarrhea/steatorrhea
  • acute abdominal pain/colic
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • anaemia
  • leukopenia/hypoleukocytosis
  • cardiac rhythm disorder/arrhythmia
  • asthma/bronchospasm
  • splenomegaly
  • portal hypertension
  • hepatomegaly/liver enlargement (excluding storage disease)
  • cirrhosis
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • ascitis
  • hot flushes/sensation of cold
  • thrombocytopenia/thrombopenia
  • urticaria

Drugs & Therapeutics for Systemic Mastocytosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Systemic Mastocytosis

Drug clinical trials:

Search ClinicalTrials for Systemic Mastocytosis

Search NIH Clinical Center for Systemic Mastocytosis

Search CenterWatch for Systemic Mastocytosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Systemic Mastocytosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Systemic Mastocytosis:
Peripheral blood-derived hematopoietic stem cells for treatment of systemic mastocytosis
Embryonic/Adult Cultured Cells Related to Systemic Mastocytosis:
Peripheral blood-derived hematopoietic stem cells (family), PMID: 10498605

Genetic Tests for Systemic Mastocytosis

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Sources:
22GTR
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Genetic tests related to Systemic Mastocytosis:

id Genetic test Affiliating Genes
1 Mast Cell Leukemia22

Anatomical Context for Systemic Mastocytosis

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32MalaCards
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MalaCards organs/tissues related to Systemic Mastocytosis:

32
Bone, Bone marrow, Skin, Myeloid, Liver, T cells, B cells, Brain, Lymph node, Spleen, Heart, Small intestine, Lung, Breast, Ovary, B lymphoblasts

Animal Models for Systemic Mastocytosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Systemic Mastocytosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.9TET2, KIT, KITLG, NRAS, STAT5A, PDGFRA
2MP:00030129.5PDGFRA, ITGAX, HDC, NRAS, CD5, KIT
3MP:00028739.4PDGFRA, STAT5A, ITGAX, NRAS, CD5, CD2
4MP:00053979.3MS4A1, PDGFRA, STAT5A, ITGAX, HDC, NRAS
5MP:00053879.2NRAS, HDC, ITGAX, STAT5A, PDGFRA, CD5
6MP:00053849.2CD5, NRAS, ITGAX, STAT5A, PDGFRA, IL2RA

Publications for Systemic Mastocytosis

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50PubMed
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Articles related to Systemic Mastocytosis:

(show top 50)    (show all 513)
idTitleAuthorsYear
1
Isolated splenomegaly as the only presentation of systemic mastocytosis. (23604430)
2013
2
The prognostic impact of c-KIT mutation in systemic mastocytosis associated with acute myeloid leukaemia patients. (23683787)
2013
3
Role of imatinib in the treatment of pediatric onset indolent systemic mastocytosis: a case report. (23659595)
2013
4
Systemic mastocytosis with associated clonal hematological non-mast cell lineage disease: clinical significance and comparison of chomosomal abnormalities in SM and AHNMD components. (23440662)
2013
5
Gene expression profile of highly purified bone marrow mast cells in systemic mastocytosis. (23403045)
2013
6
Immunophenotyping in systemic mastocytosis diagnosis: 'CD25 positive' alone is more informative than the 'CD25 and/or CD2' WHO criterion. (22222639)
2012
7
Systemic mastocytosis in adults: 2012 Update on diagnosis, risk stratification, and management. (22410759)
2012
8
Systemic mastocytosis--a systematic review. (22381091)
2012
9
High prevalence of fractures and osteoporosis in patients with indolent systemic mastocytosis. (22229787)
2012
10
Isolated bone marrow mastocytosis: an underestimated subvariant of indolent systemic mastocytosis. (21193416)
2011
11
Improved detection of the KIT D816V mutation in patients with systemic mastocytosis using a quantitative and highly sensitive real-time qPCR assay. (21354053)
2011
12
Response to cladribine in patient with systemic mastocytosis. (21739912)
2011
13
Systemic mastocytosis in adults: 2011 update on diagnosis, risk stratification, and management. (21442641)
2011
14
Omalizumab monotherapy for bee sting and unprovoked &quot;anaphylaxis&quot; in a patient with systemic mastocytosis and undetectable specific IgE. (20568389)
2010
15
Interleukin-13 promoter gene polymorphism -1112C/T is associated with the systemic form of mastocytosis. (19178408)
2009
16
Systemic mastocytosis in association with plasma cell dyscrasias: report of a case and review of the literature. (19147227)
2009
17
Multimodal therapy for vertebral involvement of systemic mastocytosis. (19644322)
2009
18
Cytoreductive therapy in 108 adults with systemic mastocytosis: Outcome analysis and response prediction during treatment with interferon-alpha, hydroxyurea, imatinib mesylate or 2-chlorodeoxyadenosine. (19890907)
2009
19
FIP1L1/PDGFRalpha synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndrome. (18539901)
2008
20
Juxtamembrane-type c-kit gene mutation found in aggressive systemic mastocytosis induces imatinib-resistant constitutive KIT activation. (17259998)
2007
21
Interstitial cystitis in a woman with systemic mastocytosis. (17124634)
2007
22
Involvement of the jaw bones in systemic mastocytosis. (15896888)
2006
23
The systemic mastocytosis-specific activating cKit mutation D816V can be inhibited by the tyrosine kinase inhibitor AMN107. (16015383)
2005
24
Shortness of breath, syncope, and cardiac arrest caused by systemic mastocytosis. (15940090)
2005
25
Interest of interferon alpha in systemic mastocytosis. The French experience and review of the literature. (15217717)
2004
26
Aggressive systemic mastocytosis mimicking sclerosing cholangitis. (15377487)
2004
27
Systemic mastocytosis. (14746529)
2004
28
Imatinib therapy in clonal eosinophilic disorders, including systemic mastocytosis. (15239393)
2004
29
CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy. (12842979)
2003
30
The many faces of systemic mastocytosis. (11476464)
2001
31
Hematologic aspects of systemic mastocytosis. (10909040)
2000
32
Severe shock during upper GI endoscopy in a patient with systemic mastocytosis. (10425425)
1999
33
An unproven technique with potentially fatal outcome: provocation/neutralization in a patient with systemic mastocytosis. (9988209)
1999
34
Residents' corner. Answer to case of the month #62. Systemic mastocytosis. (10459317)
1999
35
Systemic mastocytosis associated with acute myeloid leukaemia: report of two cases and detection of the c-kit mutation Asp-816 to Val. (9858225)
1998
36
Systemic mastocytosis. (9880960)
1998
37
Successful treatment of osteoporosis in systemic mastocytosis with interferon alpha-2b. (8605279)
1996
38
Treatment of three patients with systemic mastocytosis with interferon alpha-2b. (8882964)
1996
39
Systemic mastocytosis: a possible aetiology of nephrolithiasis. (8944528)
1996
40
Systemic mastocytosis: a diagnostic challenge. (7749967)
1995
41
Systemic mastocytosis--a case treated with interferon alpha and radiotherapy. (7828417)
1994
42
Anaphylactoid shock following Hymenoptera sting as a presenting symptom of systemic mastocytosis. (8450293)
1993
43
Radiation therapy in a case of systemic mastocytosis: evaluation of histamine levels and mucosal effects. (1381145)
1992
44
Response to interferon alfa-2b in a patient with systemic mastocytosis. (1370856)
1992
45
Systemic mastocytosis presenting with severe spinal osteopenia and multiple compression fractures. (1802168)
1991
46
Anaphylactic-like syndrome in systemic mastocytosis treated with alpha-2-interferon. (1853687)
1991
47
A case of systemic mastocytosis; therapeutic efficacy of ketotifen. (2040876)
1991
48
Systemic mastocytosis and mastocytosis-like syndrome: radiologic features of gastrointestinal manifestations. (3375878)
1988
49
Failure of sulfites to produce clinical responses in patients with systemic mastocytosis or recurrent anaphylaxis: results of a single-blind study. (3905921)
1985
50
Urticaria pigmentosa or systemic mastocytosis? (6826805)
1983

Genetic Variations for Systemic Mastocytosis

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Expression for genes affiliated with Systemic Mastocytosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Systemic Mastocytosis

Search GEO for disease gene expression data for Systemic Mastocytosis.

Pathways for genes affiliated with Systemic Mastocytosis

About this section
Sources:
53Reactome, 49PharmGKB, 37NCBI BioSystems Database, 59Tocris Bioscience, 51QIAGEN, 4Cell Signaling Technology, 29KEGG, 12EMD Millipore
See all sources

Pathways related to Systemic Mastocytosis according to GeneCards/GeneDecks:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3KITLG, KIT
210.2RAC2, NRAS
310.2KIT, KITLG, NRAS
4
Hide members
10.2KIT, KITLG, STAT5A
5
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10.2PDGFRA, NRAS, KIT
6
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10.2ITGAX, CD2, IL2RA
7
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10.1IL2RA, NRAS, STAT5A
810.1CD2, NRAS, ITGAX
910.1FCER2, RAC2, STAT5A
1010.1ITGAX, RAC2, FCER2
1110.1KIT, KITLG, IL2RA, PDGFRA
12
Hide members
10.1RAC2, NRAS, STAT5A
1310.1RAC2, NRAS, ITGAX
14
Hide members
10.1PDGFRA, NRAS, KITLG, KIT
15
Hide members
10.1KIT, KITLG, NRAS, PDGFRA
16
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10.1IFNA2, STAT5A, NRAS, IL2RA
17
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10.1IFNA2, NRAS, RAC2, FCER2
18
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10.1CD2, NRAS, ITGAX, IFNA2
19
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10.0PDGFRA, ITGAX, KIT, RAC2
20
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10.0STAT5A, NRAS, KIT, RAC2
21
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10.0STAT5A, NRAS, IL2RA, FCER2
2210.0PDGFRA, STAT5A, NRAS, IL2RA
23
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10.0PDGFRA, STAT5A, NRAS, RAC2
24
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10.0PDGFRA, ITGAX, NRAS, RAC2
25
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10.0PDGFRA, ITGAX, NRAS, RAC2
26
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10.0RAC2, NRAS, ITGAX, PDGFRA
27
Hide members
10.0PDGFRA, NRAS, IL2RA, KITLG, KIT
28
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10.0STAT5A, ITGAX, NRAS, RAC2
29
Hide members
10.0PDGFRA, STAT5A, NRAS, KITLG, KIT
30
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10.0PDGFRA, STAT5A, NRAS, KITLG, KIT
319.9IFNA2, PDGFRA, NRAS, IL2RA, KITLG, KIT
32
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9.9PDGFRA, NRAS, IL2RA, KITLG, KIT, RAC2
33
Hide members
9.9PDGFRA, NRAS, IL2RA, KITLG, KIT, RAC2
34
Hide members
9.9PDGFRA, STAT5A, NRAS, CD2, IL2RA, KIT
359.9PDGFRA, STAT5A, NRAS, KITLG, KIT, RAC2
369.9MS4A1, FCER2, KIT, KITLG, IL2RA, CD2
37
Hide members
9.8PDGFRA, NRAS, CD2, IL2RA, KITLG, KIT
38
Hide members
9.8PDGFRA, ITGAX, NRAS, IL2RA, KITLG, KIT
39
Hide members
9.8PDGFRA, ITGAX, NRAS, IL2RA, KITLG, KIT
40
Hide members
9.6PDGFRA, STAT5A, ITGAX, NRAS, KITLG, KIT
41
Hide members
9.6PDGFRA, STAT5A, ITGAX, NRAS, CD2, IL2RA
42
Hide members
9.6PDGFRA, STAT5A, ITGAX, NRAS, CD2, IL2RA
43
Hide members
9.5PDGFRA, STAT5A, ITGAX, NRAS, IL2RA, KITLG

Compounds for genes affiliated with Systemic Mastocytosis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
See all sources

Compounds related to Systemic Mastocytosis according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7ITGAX
2monochloroacetic acid4410.6KIT, KITLG
3su54164410.6STAT5A, KITLG, KIT
4mizoribine4410.6IL2RA, IFNA2
5con a4410.6IL2RA, CD2, IFNA2
6pkc 4124410.6PDGFRA, STAT5A, KIT
7aspartate4410.6HDC, STAT5A, PDGFRA
8hydroxyurea44 49 1112.5IFNA2, PDGFRA, KITLG, KIT
9ag-12964410.5PDGFRA, STAT5A, KITLG, KIT
10gp 1304410.5STAT5A, IL2RA, KITLG, KIT
11cytarabine44 49 1112.5IFNA2, STAT5A, KITLG, KIT
12cyclophosphamide44 49 1112.5IFNA2, IL2RA, KITLG, MS4A1
13pentostatin44 59 28 1113.5IFNA2, IL2RA
14hydroxychloroquine44 1111.5IL2RA, IFNA2
15ifn-alpha4410.5IL2RA, STAT5A, IFNA2
16herbimycin a44 5911.4FCER2, KITLG, IL2RA, STAT5A
17imatinib44 49 1112.4PDGFRA, STAT5A, KITLG, KIT
18neopterin4410.4FCER2, IL2RA, IFNA2
19megestrol acetate4410.4IFNA2, IL2RA
20ionomycin4410.4FCER2, IL2RA, CD2, STAT5A
21calcitriol44 59 11 2413.4PDGFRA, IL2RA, KITLG, FCER2
22rituximab44 49 1112.4MS4A1, IL2RA, IFNA2
23doxorubicin44 49 1112.4IFNA2, IL2RA, KITLG, KIT, RAC2
245fluorouracil4410.4IFNA2, IL2RA, KITLG, KIT
25toluidine4410.4KITLG, KIT
26rapamycin4410.4PDGFRA, STAT5A, IL2RA, KITLG, KIT
27fmlp4410.3STAT5A, ITGAX, RAC2, FCER2
28agar4410.3IFNA2, STAT5A, NRAS, KITLG
29Pazopanib1110.3KIT, PDGFRA
30paraffin4410.3PDGFRA, CD5, IL2RA, KITLG, KIT, FCER2
31superoxide44 2411.2IFNA2, ITGAX, KITLG, RAC2, FCER2
32vegf4410.2IFNA2, PDGFRA, STAT5A, IL2RA, KITLG, KIT
33vincristine44 49 1112.2KIT, IL2RA, IFNA2
34phosphatidylinositol4410.2PDGFRA, STAT5A, IL2RA, KITLG, KIT, RAC2
35thymidine44 2411.1IFNA2, PDGFRA, STAT5A, CD2, IL2RA, KITLG
36histamine44 28 2412.1IFNA2, HDC, IL2RA, KITLG, KIT, FCER2
37retinoic acid44 2411.1IFNA2, PDGFRA, STAT5A, ITGAX, HDC, KITLG
38steroid449.9IFNA2, STAT5A, IL2RA, KITLG, KIT
39calcium44 49 11 2412.9PDGFRA, STAT5A, HDC, CD5, CD2, KITLG
40wortmannin449.7ENPP3, KITLG, CD2, STAT5A
41tyrosine449.6SLC18A1, IFNA2, PDGFRA, STAT5A, HDC, NRAS

GO Terms for genes affiliated with Systemic Mastocytosis

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Sources:
16Gene Ontology
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Cellular components related to Systemic Mastocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.9ENPP3, MS4A1, FCER2, CD2, CD5, PDGFRA
2external side of plasma membraneGO:0098979.7MS4A1, PDGFRA, ITGAX, CD5, CD2, IL2RA
3extracellular regionGO:0055769.4IFNA2, ISM1, CD2, KITLG, FCER2, ENPP3
4plasma membraneGO:0058869.2PDGFRA, ITGAX, NRAS, CHIC2, CD5, CD2

Biological processes related to Systemic Mastocytosis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1germ cell programmed cell deathGO:03523410.6KIT, KITLG
2negative regulation of mast cell apoptotic processGO:03302610.5KITLG, STAT5A
3positive regulation of mast cell proliferationGO:07066810.5KITLG, STAT5A
4luteinizationGO:00155310.4PDGFRA, STAT5A
5positive regulation of phospholipase C activityGO:01086310.4KIT, PDGFRA
6peptidyl-tyrosine phosphorylationGO:01810810.3KIT, STAT5A, PDGFRA
7fibroblast growth factor receptor signaling pathwayGO:00854310.3PDGFRA, NRAS, KITLG, KIT
8Fc-epsilon receptor signaling pathwayGO:03809510.3PDGFRA, NRAS, KITLG, KIT
9epidermal growth factor receptor signaling pathwayGO:00717310.2PDGFRA, NRAS, KITLG, KIT
10leukocyte migrationGO:05090010.1CD2, NRAS, ITGAX
11neurotrophin TRK receptor signaling pathwayGO:04801110.0PDGFRA, NRAS, KITLG, KIT
12blood coagulationGO:0075969.9IFNA2, ITGAX, NRAS, CD2, RAC2
13innate immune responseGO:0450879.7IFNA2, PDGFRA, NRAS, KITLG, KIT

Products for genes affiliated with Systemic Mastocytosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Systemic Mastocytosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet