SMCD
MCID: SYS004
MIFTS: 70

Systemic Mastocytosis (SMCD) malady

Blood diseases, Cancer diseases categories

Summaries for Systemic Mastocytosis

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Systemic mastocytosis is a condition caused by the accumulation of mast cells in more than one part of the body. mast cells contain substances such as histamine that regulate allergic reactions. in systemic mastocytosis, mast cells may build up in the bone marrow, internal organs, or in the skin. this condition is usually diagnosed in adults. treatment is generally based on a person's symptoms, but it may include antihistamines (to prevent the effect of mast cell histamine) or chemotherapy for more aggressive forms.there are several different types of systemic mastocytosis. indolent systemic mastocytosis develops slowly, while aggressive systemic mastocytosis develops more rapidly. another form, called systemic mastocytosis with associated hemotologic non-mast cell lineage disease (sm-ahnmd), is characterized by the presence of several types of blood disorders. mast cell leukemia is a rare form of systemic mastocytosis. last updated: 10/5/2012

MalaCards: Systemic Mastocytosis, also known as mast cell leukemia, is related to indolent systemic mastocytosis and leukemia, and has symptoms including eosinophils anomalies/hypereosinophilia, bone marrow failure/pancytopenia and mastocytosis. An important gene associated with Systemic Mastocytosis is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Regulation of KIT signaling and Bisphosphonate Pathway, Pharmacodynamics. The compounds cycloheximide and monochloroacetic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and skin, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Aliases & Classifications for Systemic Mastocytosis

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42NIH Rare Diseases, 60UMLS, 10DISEASES, 8Disease Ontology, 48Orphanet, 30LifeMap Discovery™, 22GTR, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
systemic mastocytosis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age
mast cell leukemia:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Variable


Aliases & Descriptions:

systemic mastocytosis 8 42 10 48 30
mast cell leukemia 42 22 48
indolent systemic mastocytosis 42 60
corneal dystrophy, subepithelial mucinous 60
systemic tissue mast cell disease 8
smcd - systemic mast cell disease 8
agressive systemic mastocytosis 42
systemic mast cell disease 42
mastocytosis, systemic 60
mastocytosis systemic 44
leukemia, mast-cell 60
mast-cell leukemia 10
leukemia mast cell 44
mast cell disease 48
smcd 42


External Ids:

Disease Ontology8 DOID:349
NCIt39 C9235
MeSH34 D034721
MESH via Orphanet35 D034721, D007946
ICD10 via Orphanet26 C96.2, C94.3
SNOMED-CT via Orphanet57 397016004, 110002002, 128924002
UMLS via Orphanet61 C0221013, C0023461

Related Diseases for Systemic Mastocytosis

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17GeneCards, 18GeneDecks
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Diseases in the Systemic Mastocytosis family:

Mastocytosis

Diseases related to Systemic Mastocytosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1indolent systemic mastocytosis31.1ISM1
2leukemia31.1STAT5A, CD5, ITGAX, KITLG, KIT, FCER2
3acute leukemia30.8ITGAX, STAT5A, KITLG, KIT
4myeloid leukemia30.8STAT5A, KITLG, KIT
5acute myeloid leukemia30.8KIT, CHIC2
6mast-cell leukemia30.7KIT, KITLG
7urticaria30.7FCER2
8urticaria pigmentosa30.7KIT, KITLG
9sm-ahnmd30.6ENPP3
10eosinophilia30.4FCER2, IL2RA, CD2, CHIC2, PDGFRA, IFNA2
11myeloma30.4STAT5A, IFNA2, FCER2, KITLG
12mast cell neoplasm30.3KIT, KITLG, HDC
13myelofibrosis30.3KIT, STAT5A
14pancreatitis30.1KITLG, NRAS
15sarcoma30.1NRAS, FCER2, KIT, KITLG, PDGFRA
16chronic lymphocytic leukemia30.1MS4A1, FCER2, IL2RA, CD5, HDC
17mastocytosis30.1PDGFRA, IFNA2, HDC, CHIC2, TPSAB1, KIT
18hepatitis29.9IFNA2
19nephrotic syndrome29.9IL2RA
20thrombocytosis29.9IFNA2, KITLG, TET2
21asthma29.9HDC, FCER2, KITLG, IL2RA, STAT5A
22melanoma29.9IFNA2, HDC, KIT, STAT5A, KITLG, CD2
23aggressive systemic mastocytosis10.7
24osteoporosis10.5
25cutaneous mastocytosis10.4
26gastrointestinal system disease10.3
27splenic disease10.3
28portal hypertension10.3
29hypertension10.3
30classic mast cell leukemia10.2
31aleukemic mast cell leukemia10.2
32bone fracture10.2
33diarrhea10.2
34subepithelial mucinous corneal dystrophy10.2
35microphthalmia10.2
36osteopetrosis10.1
37splenic infarction10.1
38ovarian disease10.1
39mast-cell sarcoma10.1
40cholangitis10.1
41cholestasis10.1
42disseminated intravascular coagulation10.1
43histiocytosis10.1
44inflammatory bowel disease10.1
45smouldering systemic mastocytosis10.1
46systemic mastocytosis with an associated clonal hematologic non-mast cell lineage disease10.1
47monocytic leukemia10.1
48felty's syndrome10.0
49liver cirrhosis10.0
50liver disease10.0

Graphical network of the top 20 diseases related to Systemic Mastocytosis:



Diseases related to systemic mastocytosis

Clinical Features for Systemic Mastocytosis

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48Orphanet
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Symptoms:

48 (show all 34)
  • eosinophils anomalies/hypereosinophilia
  • bone marrow failure/pancytopenia
  • mastocytosis
  • severe allergic reaction/atopy
  • anomalies of the hematological system
  • leukopenia/hypoleukocytosis
  • hot flushes/sensation of cold
  • portal hypertension
  • lymphadenopathy/polyadenopathies
  • bone pain
  • myeloproliferative syndrome/chronic leukemia
  • osteosclerosis/osteopetrosis/bone condensation
  • anaemia
  • ascitis
  • cardiac rhythm disorder/arrhythmia
  • articular/joint pain/arthralgia
  • malabsorption/chronic diarrhea/steatorrhea
  • splenomegaly
  • hepatomegaly/liver enlargement (excluding storage disease)
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • cutaneous rash
  • mutiple fractures/bone fragility
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • asthma/bronchospasm
  • acute leukemia
  • facial pain/cephalalgia/migraine
  • thrombocytopenia/thrombopenia
  • osteolysis/osteoclasia/bone destruction/erosions
  • cirrhosis
  • acute abdominal pain/colic
  • urticaria
  • myalgia/muscular pain
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Systemic Mastocytosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Systemic Mastocytosis

Drug clinical trials:

Search ClinicalTrials for Systemic Mastocytosis

Search NIH Clinical Center for Systemic Mastocytosis

Search CenterWatch for Systemic Mastocytosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Systemic Mastocytosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Systemic Mastocytosis:
Peripheral blood-derived hematopoietic stem cells for treatment of systemic mastocytosis
Embryonic/Adult Cultured Cells Related to Systemic Mastocytosis:
Peripheral blood-derived hematopoietic stem cells (family), PMID: 10498605

Genetic Tests for Systemic Mastocytosis

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22GTR
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Genetic tests related to Systemic Mastocytosis:

id Genetic test Affiliating Genes
1 Mast Cell Leukemia22

Anatomical Context for Systemic Mastocytosis

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32MalaCards
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MalaCards organs/tissues related to Systemic Mastocytosis:

32
Bone, Bone marrow, Skin, Myeloid, Liver, B cells, T cells, B lymphoblasts, Brain, Ovary, Lymph node, Lung, Spleen, Heart, Breast, Small intestine

Animal Models for Systemic Mastocytosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Systemic Mastocytosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.9TET2, KIT, KITLG, NRAS, STAT5A, PDGFRA
2MP:00030129.5PDGFRA, ITGAX, HDC, NRAS, CD5, TET2
3MP:00028739.4TET2, PDGFRA, SLC18A1, KIT, CD2, CD5
4MP:00053979.3MS4A1, TET2, STAT5A, FCER2, RAC2, KITLG
5MP:00053879.2CD5, NRAS, HDC, PDGFRA, STAT5A, IL2RA
6MP:00053849.2IL2RA, MS4A1, TET2, SLC18A1, FCER2, RAC2

Publications for Systemic Mastocytosis

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50PubMed
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Articles related to Systemic Mastocytosis:

(show top 50)    (show all 513)
idTitleAuthorsYear
1
KIT D816V mutation detection: a comparative study using peripheral blood, bone marrow aspirate and bone marrow trephine samples for detection of KIT mutations in patients with systemic mastocytosis. (24359244)
2014
2
Omalizumab Induced Remission of Idiopathic Anaphylaxis in a Patient Suffering from Indolent Systemic Mastocytosis. (24162824)
2013
3
Systemic mastocytosis presenting as Kounis syndrome. (24267372)
2013
4
Lack of evidence for intrathecal tryptase synthesis in patients with systemic mastocytosis. (23810768)
2013
5
Systemic mastocytosis presenting as acute appendicitis: a case report and review of the literature. (23626557)
2013
6
Smouldering systemic mastocytosis with lymph node involvement mimicking malignant lymphoma. (24337517)
2013
7
Systemic mastocytosis with associated clonal hematologic nonmast cell lineage disease: a clinicopathologic review. (22742558)
2012
8
Complete response after imatinib mesylate therapy in a patient with well-differentiated systemic mastocytosis. (22370312)
2012
9
Validation of the REMA score for predicting mast cell clonality and systemic mastocytosis in patients with systemic mast cell activation symptoms. (22042301)
2012
10
Systemic mastocytosis complicating pregnancy. (22270448)
2012
11
Systemic mastocytosis with associated acute myeloid leukemia with t (8; 21) (q22; q22). (23032848)
2012
12
Systemic mastocytosis (SM) and associated malignant bone marrow histiocytosis - a hitherto undescribed form of SM-AHNMD. (21866466)
2011
13
KIT-D816V-independent oncogenic signaling in neoplastic cells in systemic mastocytosis: role of Lyn and Btk activation and disruption by dasatinib and bosutinib. (21680801)
2011
14
Gene expression analysis predicts insect venom anaphylaxis in indolent systemic mastocytosis. (21143240)
2011
15
Clonal analysis of NRAS activating mutations in KIT-D816V systemic mastocytosis. (21134978)
2011
16
Aggressive systemic mastocytosis with Charcot-Leyden crystals-associated crystal storing histiocytosis in bone marrow. (20025488)
2010
17
Spontaneous extracutaneous systemic mastocytosis in a cynomolgus macaque (Macaca fascicularis). (19545986)
2010
18
Hypotension, Syncope, and Fever in Systemic Mastocytosis without Skin Infiltration and Rapid Response to Corticosteroid and Cyclosporin: A Case Report. (21209730)
2010
19
Systemic mastocytosis as a rare cause of diffuse gastrointestinal hemorrhage. (19445297)
2009
20
Distinct clonal origins of systemic mastocytosis and associated B-cell lymphoma. (17544505)
2007
21
Case report: pathologic long bone fracture in a patient with systemic mastocytosis. (17327804)
2007
22
Aggressive systemic mastocytosis with sarcoma-like growth in the skeleton, leukemic progression, and partial loss of mast cell differentiation antigens. (18055976)
2007
23
Neoplastic mast cells in systemic mastocytosis associated with t(8;21) acute myeloid leukemia are derived from the leukemic clone. (16876862)
2007
24
An unusual case of systemic mastocytosis associated with chronic lymphocytic leukaemia (SM-CLL). (16505276)
2006
25
Indolent systemic mastocytosis as the cause of a long history of unexplained hypotensive episodes. (16929885)
2006
26
Delineation of patterns of bone marrow mast cell infiltration in systemic mastocytosis: value of CD25, correlation with subvariants of the disease, and separation from mast cell hyperplasia. (16146815)
2005
27
Indolent systemic mastocytosis with elevated serum tryptase, absence of skin lesions, and recurrent severe anaphylactoid episodes. (15722637)
2005
28
Response to therapy with interferon alpha-2b and prednisolone in aggressive systemic mastocytosis: report of five cases and review of the literature. (14687620)
2004
29
Management of patients with systemic mastocytosis: review of M. D. Anderson Cancer Center experience. (15495258)
2004
30
Relationship between idiopathic hypereosinophilic syndrome, eosinophilic leukemia, and systemic mastocytosis. (15307112)
2004
31
Systemic mastocytosis: current concepts and treatment advances. (15087068)
2004
32
Systemic mastocytosis with associated clonal hematological non-mast-cell lineage disease: analysis of clinicopathologic features and activating c-kit mutations. (12701114)
2003
33
Familial urticaria pigmentosa associated with thrombocytosis as the initial symptom of systemic mastocytosis and Down's syndrome. (14761147)
2003
34
Pathologic quiz case. Systemic mastocytosis. (10747334)
2000
35
C-kit activating mutation in a neonate with in-utero presentation of systemic mastocytosis associated with myeloproliferative disorder. (10468886)
1999
36
Diffuse cutaneous mastocytosis without systemic involvement : Response to topical augmented betamethasone dipropionate under plastic occlusion. (20944388)
1997
37
Systemic mastocytosis associated with chronic myelomonocytic leukemia: clinical features and response to interferon alfa therapy. (7722042)
1995
38
Acute nonlymphocytic leukemia in systemic mastocytosis with biclonal gammopathy. (1527326)
1992
39
Pingueculae in systemic mastocytosis: a possible association. (1489303)
1992
40
Systemic mastocytosis and SjAPgren's syndrome. (1444641)
1992
41
Osteoporotic vertebral fractures in systemic mastocytosis without skin involvement]. (1330476)
1992
42
Systemic mastocytosis with skeletal involvement. (1816988)
1991
43
Inhibition of mediator release in systemic mastocytosis is associated with reversal of bone changes. (2270775)
1990
44
Aspirin and systemic mastocytosis. (2572872)
1989
45
Systemic mastocytosis associated with membranous nephropathy and peripheral neuropathy. (2848413)
1988
46
Carcinoid syndrome and disorders of systemic mast-cell activation including systemic mastocytosis. (3042393)
1988
47
Radiologic case study. Systemic mastocytosis. (2869475)
1985
48
Systemic mastocytosis with extensive large cutaneous mastocytomas: surgical management. (3935876)
1985
49
Comparison of the therapeutic efficacy of cromolyn sodium with that of combined chlorpheniramine and cimetidine in systemic mastocytosis. Results of a double-blind clinical trial. (3917606)
1985
50
Effects of metiamide on gastric acid hypersecretion, steatorrhea, and bone-marrow function in a patient with systemic mastocytosis. (980022)
1976

Genetic Variations for Systemic Mastocytosis

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Expression for genes affiliated with Systemic Mastocytosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Systemic Mastocytosis

Search GEO for disease gene expression data for Systemic Mastocytosis.

Pathways for genes affiliated with Systemic Mastocytosis

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Sources:
53Reactome, 49PharmGKB, 37NCBI BioSystems Database, 59Tocris Bioscience, 51QIAGEN, 4Cell Signaling Technology, 29KEGG, 12EMD Millipore
See all sources

Pathways related to Systemic Mastocytosis according to GeneCards/GeneDecks:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3KIT, KITLG
210.2NRAS, RAC2
310.2KITLG, NRAS, KIT
4
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10.2STAT5A, KITLG, KIT
5
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10.2KIT, NRAS, PDGFRA
6
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10.2ITGAX, CD2, IL2RA
7
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10.1IL2RA, NRAS, STAT5A
810.1NRAS, ITGAX, CD2
910.1STAT5A, RAC2, FCER2
1010.1FCER2, ITGAX, RAC2
1110.1KITLG, KIT, IL2RA, PDGFRA
12
Hide members
10.1RAC2, STAT5A, NRAS
1310.1ITGAX, NRAS, RAC2
14
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10.1PDGFRA, NRAS, KITLG, KIT
15
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10.1KIT, PDGFRA, KITLG, NRAS
16
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10.1IFNA2, STAT5A, IL2RA, NRAS
17
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10.1IFNA2, NRAS, RAC2, FCER2
18
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10.1IFNA2, CD2, NRAS, ITGAX
19
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10.0PDGFRA, ITGAX, KIT, RAC2
20
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10.0KIT, NRAS, STAT5A, RAC2
21
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10.0IL2RA, FCER2, NRAS, STAT5A
2210.0PDGFRA, NRAS, STAT5A, IL2RA
23
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10.0STAT5A, NRAS, RAC2, PDGFRA
24
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10.0PDGFRA, ITGAX, NRAS, RAC2
25
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10.0PDGFRA, ITGAX, NRAS, RAC2
26
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10.0ITGAX, NRAS, RAC2, PDGFRA
27
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10.0PDGFRA, KIT, KITLG, NRAS, IL2RA
28
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10.0ITGAX, RAC2, STAT5A, NRAS
29
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10.0NRAS, STAT5A, PDGFRA, KIT, KITLG
30
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10.0KIT, KITLG, NRAS, STAT5A, PDGFRA
319.9NRAS, KIT, KITLG, IL2RA, IFNA2, PDGFRA
32
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9.9RAC2, KIT, KITLG, IL2RA, NRAS, PDGFRA
33
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9.9RAC2, KIT, PDGFRA, NRAS, IL2RA, KITLG
34
Hide members
9.9PDGFRA, STAT5A, NRAS, CD2, KIT, IL2RA
359.9PDGFRA, STAT5A, NRAS, KITLG, KIT, RAC2
369.9MS4A1, CD5, CD2, IL2RA, FCER2, KIT
37
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9.8PDGFRA, IL2RA, NRAS, CD2, KITLG, KIT
38
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9.8PDGFRA, ITGAX, NRAS, IL2RA, KITLG, KIT
39
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9.8PDGFRA, RAC2, KIT, KITLG, IL2RA, NRAS
40
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9.6KIT, RAC2, KITLG, PDGFRA, STAT5A, NRAS
41
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9.6ITGAX, PDGFRA, KIT, RAC2, KITLG, IL2RA
42
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9.6KIT, STAT5A, RAC2, CD2, KITLG, IL2RA
43
Hide members
9.5KIT, FCER2, KITLG, RAC2, IL2RA, NRAS

Compounds for genes affiliated with Systemic Mastocytosis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Systemic Mastocytosis according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7ITGAX
2monochloroacetic acid4410.6KIT, KITLG
3su54164410.6STAT5A, KITLG, KIT
4mizoribine4410.6IL2RA, IFNA2
5con a4410.6IL2RA, CD2, IFNA2
6pkc 4124410.6PDGFRA, STAT5A, KIT
7aspartate4410.6HDC, STAT5A, PDGFRA
8hydroxyurea44 49 1112.5IFNA2, PDGFRA, KITLG, KIT
9ag-12964410.5PDGFRA, STAT5A, KITLG, KIT
10gp 1304410.5STAT5A, IL2RA, KITLG, KIT
11cytarabine44 49 1112.5IFNA2, STAT5A, KITLG, KIT
12cyclophosphamide44 49 1112.5IFNA2, IL2RA, KITLG, MS4A1
13pentostatin44 59 28 1113.5IFNA2, IL2RA
14hydroxychloroquine44 1111.5IL2RA, IFNA2
15ifn-alpha4410.5IL2RA, STAT5A, IFNA2
16herbimycin a44 5911.4FCER2, KITLG, IL2RA, STAT5A
17imatinib44 49 1112.4PDGFRA, STAT5A, KITLG, KIT
18neopterin4410.4FCER2, IL2RA, IFNA2
19megestrol acetate4410.4IFNA2, IL2RA
20ionomycin4410.4FCER2, IL2RA, CD2, STAT5A
21calcitriol44 59 11 2413.4PDGFRA, IL2RA, KITLG, FCER2
22rituximab44 49 1112.4MS4A1, IL2RA, IFNA2
23doxorubicin44 49 1112.4IFNA2, IL2RA, KITLG, KIT, RAC2
245fluorouracil4410.4IFNA2, IL2RA, KITLG, KIT
25toluidine4410.4KITLG, KIT
26rapamycin4410.4PDGFRA, STAT5A, IL2RA, KITLG, KIT
27fmlp4410.3STAT5A, ITGAX, RAC2, FCER2
28agar4410.3IFNA2, STAT5A, NRAS, KITLG
29Pazopanib1110.3KIT, PDGFRA
30paraffin4410.3PDGFRA, CD5, IL2RA, KITLG, KIT, FCER2
31superoxide44 2411.2IFNA2, ITGAX, KITLG, RAC2, FCER2
32vegf4410.2IFNA2, PDGFRA, STAT5A, IL2RA, KITLG, KIT
33vincristine44 49 1112.2KIT, IL2RA, IFNA2
34phosphatidylinositol4410.2PDGFRA, STAT5A, IL2RA, KITLG, KIT, RAC2
35thymidine44 2411.1IFNA2, PDGFRA, STAT5A, CD2, IL2RA, KITLG
36histamine44 28 2412.1IFNA2, HDC, IL2RA, KITLG, KIT, FCER2
37retinoic acid44 2411.1IFNA2, PDGFRA, STAT5A, ITGAX, HDC, KITLG
38steroid449.9IFNA2, STAT5A, IL2RA, KITLG, KIT
39calcium44 49 11 2412.9PDGFRA, STAT5A, HDC, CD5, CD2, KITLG
40wortmannin449.7ENPP3, KITLG, CD2, STAT5A
41tyrosine449.6SLC18A1, IFNA2, PDGFRA, STAT5A, HDC, NRAS

GO Terms for genes affiliated with Systemic Mastocytosis

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Sources:
16Gene Ontology
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Cellular components related to Systemic Mastocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.9PDGFRA, CD2, FCER2, MS4A1, ENPP3, CD5
2external side of plasma membraneGO:0098979.7PDGFRA, MS4A1, FCER2, KIT, IL2RA, CD2
3extracellular regionGO:0055769.4ENPP3, KITLG, CD2, ISM1, IFNA2, FCER2
4plasma membraneGO:0058869.2PDGFRA, ITGAX, NRAS, CHIC2, CD5, CD2

Biological processes related to Systemic Mastocytosis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1germ cell programmed cell deathGO:03523410.6KIT, KITLG
2negative regulation of mast cell apoptotic processGO:03302610.5KITLG, STAT5A
3positive regulation of mast cell proliferationGO:07066810.5KITLG, STAT5A
4luteinizationGO:00155310.4STAT5A, PDGFRA
5positive regulation of phospholipase C activityGO:01086310.4KIT, PDGFRA
6peptidyl-tyrosine phosphorylationGO:01810810.3PDGFRA, STAT5A, KIT
7fibroblast growth factor receptor signaling pathwayGO:00854310.3NRAS, PDGFRA, KITLG, KIT
8Fc-epsilon receptor signaling pathwayGO:03809510.3NRAS, KIT, KITLG, PDGFRA
9epidermal growth factor receptor signaling pathwayGO:00717310.2NRAS, KIT, KITLG, PDGFRA
10leukocyte migrationGO:05090010.1CD2, NRAS, ITGAX
11neurotrophin TRK receptor signaling pathwayGO:04801110.0PDGFRA, NRAS, KITLG, KIT
12blood coagulationGO:0075969.9NRAS, ITGAX, CD2, IFNA2, RAC2
13innate immune responseGO:0450879.7IFNA2, NRAS, KITLG, KIT, PDGFRA

Products for genes affiliated with Systemic Mastocytosis

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  • Antibodies
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Sources for Systemic Mastocytosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet