MCID: SYS034
MIFTS: 60

Systemic Onset Juvenile Idiopathic Arthritis malady

Categories: Rare diseases, Respiratory diseases, Bone diseases

Aliases & Classifications for Systemic Onset Juvenile Idiopathic Arthritis

About this section
Sources:
45NIH Rare Diseases, 47Novoseek, 51Orphanet, 65UMLS, 28ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Systemic Onset Juvenile Idiopathic Arthritis:

Name: Systemic Onset Juvenile Idiopathic Arthritis 45
Systemic-Onset Juvenile Idiopathic Arthritis 51
Systemic Onset Juvenile Rheumatoid Arthritis 45
Systemic Onset Juvenile Chronic Arthritis 65
Systemic Juvenile Idiopathic Arthritis 45
Juvenile-Onset Still Disease 65
 
Systemic Polyarthritis 51
Systemic-Onset Jia 51
Still's Disease 45
Stills Disease 47
Still Disease 51

Characteristics:

Orphanet epidemiological data:

51
systemic-onset juvenile idiopathic arthritis:
Prevalence: 1-9/100000 (Europe); Age of onset: Childhood; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet51 85414
ICD10 via Orphanet28 M08.2
UMLS65 C1384600, C0087031

Summaries for Systemic Onset Juvenile Idiopathic Arthritis

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Wikipedia:68 Systemic onset juvenile idiopathic arthritis (also known as systemic juvenile idiopathic arthritis... more...

MalaCards based summary: Systemic Onset Juvenile Idiopathic Arthritis, also known as systemic-onset juvenile idiopathic arthritis, is related to rheumatoid arthritis and macrophage activation syndrome, and has symptoms including cutaneous rash, articular/joint pain/arthralgia and hydrarthrosis/articular/joint effusion. An important gene associated with Systemic Onset Juvenile Idiopathic Arthritis is LACC1 (Laccase Domain Containing 1), and among its related pathways are Cytokines and Inflammatory Response and African trypanosomiasis. Affiliated tissues include bone, liver and thyroid, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Related Diseases for Systemic Onset Juvenile Idiopathic Arthritis

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Diseases related to Systemic Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis27.9IL1R1, IL1RN, IL6, MIF, TNF
2macrophage activation syndrome11.0
3arthritis10.9
4rhizomelic dysplasia patterson lowry type10.6MIF, TNF
5hypersensitivity reaction type iii disease10.6MIF, TNF
6macrophagic myofasciitis10.6PRF1, TNF
7multiple sclerosis 510.6MEFV, TNF
8rhinoscleroma10.5MEFV, TNF
9congenital nasal pyriform aperture stenosis with holoprosencephaly10.5PRF1, TNF
10gastric leiomyosarcoma10.4IL1RN, MEFV
11sarcoidosis, early-onset10.4MEFV, TNF
12peripheral artery disease10.4IL1RN, MEFV
13familial mediterranean fever, ad10.3MEFV, TNF
14blue color blindness10.3MEFV, TNF
15kawasaki disease10.3
16optic neuritis10.3IL6, PRF1
17plantar nerve lesion10.3IL6, TNF
18human granulocytic anaplasmosis10.3IL6, MIF
19intermediate dend syndrome10.3IL6, TNF
20crohn's disease10.3IL6, TNF
21eyelid neoplasm10.3IL6, PRF1
22malignant sertoli-leydig cell tumor of ovary10.3IL6, TNF
23mammary paget's disease10.3IL6, TNF
24lujo hemorrhagic fever10.3IL6, TNF
25posterior valve urethra10.3IL6, TNF
26residual stage angle-closure glaucoma10.3IL6, TNF
27parovarian cyst10.3IL6, TNF
28collagenous colitis10.3IL6, TNF
29paranoid schizophrenia10.3IL6, TNF
30ischemic optic neuropathy10.3IL6, TNF
31blue toe syndrome10.3IL6, PRF1
32early-onset, autosomal dominant alzheimer disease10.3IL6, TNF
33skin conditions10.3IL6, TNF
34tick-borne relapsing fever10.3IL6, TNF
35cryoglobulinemia10.3IL1RN, TNF
36postsurgical hypothyroidism10.3IL6, TNF
37hemorrhagic proctocolitis10.2IL6, TNF
38dancing eyes-dancing feet syndrome10.2IL6, TNF
39partial circumpapillary choroid dystrophy10.2IL6, MEFV
40hemolytic anemia10.2IL6, TNF
41diffuse intraductal papillomatosis10.2IL6, TNF
42rubeosis iridis10.2IL6, TNF
43duodenum cancer10.2IL6, TNF
44pustulosis palmaris et plantaris10.2IL1RN, TNF
45dentin caries10.2IL6, TNF
46meige syndrome10.2IL6, TNF
47thyroiditis10.2IL1RN, IL6
48vagus nerve neoplasm10.2IL6, TNF
49basilar artery occlusion10.2IL6, TNF
50submandibular gland disease10.1IL6, TNF

Graphical network of the top 20 diseases related to Systemic Onset Juvenile Idiopathic Arthritis:



Diseases related to systemic onset juvenile idiopathic arthritis

Symptoms for Systemic Onset Juvenile Idiopathic Arthritis

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Symptoms:

 51 (show all 13)
  • cutaneous rash
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • arthritis/synovitis/synovial proliferation
  • autoimmunity/autoimmune reaction/autoantibodies
  • fever/chilling
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • mediastinal/hilar adenopathies
  • acute abdominal pain/colic
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion

Drugs & Therapeutics for Systemic Onset Juvenile Idiopathic Arthritis

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Drugs for Systemic Onset Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Immunologic FactorsPhase 4, Phase 318483
2Antibodies, MonoclonalPhase 4, Phase 3, Phase 1, Phase 22413
3ImmunoglobulinsPhase 4, Phase 3, Phase 1, Phase 24477
4AntibodiesPhase 4, Phase 3, Phase 1, Phase 24477
5Liver ExtractsPhase 43572
6
BenzocaineapprovedPhase 316841994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
20/20 Topical Anesthetic
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Alcohol Prep Pads
Allegenal-m
Alpha-caine Topical Anesthetic
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anbesol Jr
Anbesol Maximum Strength
Anbesol Regular Strength
Anestenka
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthetic
Anesthone
Atopalm Oral Pain Relief
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Baby Anestenka
Baby Sensigel
Baby Sensigel Night Time Formula
Baby Teething Oral Pain Reliever
Bactimicina For Sore Throat
Bencocaine Topical Anesthetic
Bensokain
Benz O Sthetic
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzodent
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
Boil Ease
Boy Butter Desensitizing Lubricant
Boy Butter Extreme Desensitizing Lubricant
Boy Butter Extreme H2O Desensitizing Lubricant
Brace Relief
Budpak Baby Teething Oral Pain Reliever
Budpak Oral Maximum Strength
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Carmex Cold Sore Treatment External Analgesic
Caswell No. 430A
Cepacol Fizzlers
Cepacol Sensations Hydra
Cepacol Sensations Sore Throat Hydra citrus splash
Cepacol Sensations Warming
Certus Sting Relief Prep Pad
Chloraseptic
Chloraseptic Warming Sore Throat
Colgate Orabase
Comfortcaine Topical Anesthetic
Cvs Fast Acting Baby Teething
Cvs Maximum Strength
Cvs Maximum Strength Boil Relief
Cvs Oral Anesthetic
Cvs Pharmacy Instant Toothache
Cvs Pharmacy Maximum Strength
Cvs Pharmacy Mouth Sore Gel
Cvs Pharmacy Nighttime Oral Pain Relief
D001566
D00552
DB01086
Dental Relief
Dentek Instant Pain Relief Maximum Strength
Dermoplast
Diet Ayds
DivK1c_000932
Dollar General Toothache Relief
Dukal Sting Relief Pad
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Finafta Baby
Finafta MultiOral
Formate, Benzocaine
Gelato Topical Anesthetic
Good Neighbor Pain Relief
Goodsense Oral Pain Relief
Gps Topical Anesthetic
Gumnumb Topical Anesthetic
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Heb Severe Toothache
Herbasoul Male Genital Desensitizer Cream
 
Hurricaine
Hurricaine Topical Anesthetic
Hurricaine Topical Anesthetic Gel
Hurricaine Topical Anesthetic Liquid
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
Insect Bite Relief
Instant Toothache Pain Relief
Intense Cvs Intense Toothache
Iodent Maximum Strength Oral Analgesic
Ismile Topical Anesthetic
Jianze Sting Relief Pads
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Kank-a Mouth Pain
Keloform
Kmart Smart Sense
Kroger Toothache Pain Relief
LS-35847
Leader Oral Analgesic
Little Colds Sore Throat Relief Melt Aways
MLS001331704
MLS002153970
Makesense Junior Pain Relief
Makesense Pain Relief
Male Desensitizer Pleasure Balm
Mandelay Male Genital Desensitizer
Mark 3
Methanesulfonate, Benzocaine
MolPort-000-871-526
Mouth Sore Medication
Mouth Sore Relief Applicator
Mouth Sore Relief Professional Strength
My Fair Baby Instant Pain Relief
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Nene Dente
Norcain
Norcaine
Norcainum
Opahl
Opahl Dye Free
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orajel For All Mouth Sores Maximum Strength
Orajel For Cold Sores
Orajel For Toothache Maximum Strength
Orajel Instant Pain Relief Maximum Strength
Orajel Instant Pain Relief Regular Strength
Orajel Instant Relief For Teething Pain
Orajel Instant Relief For Teething Pain Cooling Cucumber
Orajel Instant Relief For Teething Pain Daytime Nighttime Twin Pack
Orajel Instant Relief For Teething Pain Longer Lasting
Orajel Maximum Strength
Orajel Nighttime Instant Relief For Teething Pain Longer Lasting Extra Strength
Orajel Severe Toothache Maximum Strength Fast-Acting Formula
Oral Analgesic Maximum Strength
Oral B Instant Pain Relief
Oral Gel Maximum Strength
Oral Pain Relief Anesthetic Anesthetic
Oral Pain Reliever
Oralabs Cold Sore Treatment
Orthesin
Otocain
Outgro
Pac-dent Top Gel
Pain Relief
Pain Relief Alcohol Swabs
Parathesin
Parathesin (TN)
Parathesine
Physicians Care Sting Relief Pad
Pleasure Balm Kama Sutra
Preboost
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
Purelife Topical Anesthetic
Quality Choice Maximum Strength Oral Pain Relieving
Red Cross Oral Pain Relief
Rexall Maximum Strength
Rite Aid Baby Care
Rite Aid Liquid Anesthetic Oral Pain Relief
Rite Aid Maximum Strength
Rite Aid Oral Pain Reliever
Rite Aid Professional Strength
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Sally Hansen Ouch-relief Numbing Wipes
Sally Hansen Ouch-relief Wax Kit
Sally Hansen Ouch-relief Wax Strip Kit
Sensigel
Severe Oral Pain Reliever
Sheffield Baby Teething Gel
Sheffield Pain Relief
Shunga Male Genital Desensitizer
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Sting Relief Medicated Pad
Sting Relief Pads
Tanac
Terrasil Boil Pain Relief
Tiger Supply Inc Topical Anesthetic
Top Quality Mfg. Topical Anesthetic
Topcaine
Topcare Maximum Strength
Topical Anesthetic Banana
Topical Anesthetic Bubble Gum
Topical Anesthetic Cherry
Topical Anesthetic Mint
Topical Anesthetic Pina Colada
Topical Anesthetic Raspberry
Topical Anesthetic Strawberry
UNII-U3RSY48JW5
Ultracare Anesthetic Bubble Gum
Ultracare Anesthetic Butter Rum
Ultracare Anesthetic Creme de Menthe
Ultracare Anesthetic Pina Colada
Ultracare Anesthetic Walterberry
WLN: ZR DVO2
Walgreens Baby Teething
Walgreens Intense Toothache
Walgreens Maximum Strength
Walgreens Pain Relieving For Boils
Walgreens Severe Oral Pain Reliever
Walgreens Severe Toothache Relief
Winco Foods Maximum Strength Oral Analgesic
ZINC12358719
Zilactin-b
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
7
MethotrexateapprovedPhase 314441959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
Methopterin
Methotextrate
 
Methotrate
Methotrexat
Methotrexate
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metoject
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Otrexup
Rasuvo
Rheumatrex
Rheumatrex Dose Pack
Trexall
8
PrednisoneapprovedPhase 3126753-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
Juvason
 
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Perrigo Prednisone
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rayos
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
9
AlendronateapprovedPhase 2, Phase 3155121268-17-5, 66376-36-12088
Synonyms:
(4-Amino-1-hydroxybutylidene)bisphosphonic acid
(4-Amino-1-hydroxybutylidene)diphosphonic acid
(4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid
(4-amino-1-hydroxybutane-1,1-diyl)bis(phosphonic acid)
121268-17-5 (mono-hydrochloride salt, trihydrate)
1yhm
4-Amino-1-hydroxybutane-1,1-diphosphonate
4-Amino-1-hydroxybutane-1,1-diphosphonic Acid
4-Amino-1-hydroxybutylidene-1,1-bis(phosphonic acid)
4-Amino-1-hydroxybutylidene-1,1-bisphosphonate
66376-36-1
AC1L1CW3
AKOS001015793
ALENDRONATE SODIUM
ALENDRONIC ACID
Acide Alendronique
Acide Alendronique [INN-French]
Acide alendronique
Acide alendronique [INN-French]
Acido Alendronico
Acido Alendronico [INN-Spanish]
Acido alendronico
Acido alendronico [INN-Spanish]
Acidum Alendronicum
Acidum Alendronicum [INN-Latin]
Acidum alendronicum
Acidum alendronicum [INN-Latin]
Adronat
Alendronate
Alendronate Sodium
 
Alendronate sodium hydrate
Alendronic acid
Alendronic acid (INN)
Alendronic acid [INN:BAN]
Alendros
Arendal
BIDD:GT0180
Binosto
C07752
CHEBI:2567
CHEMBL870
CID2088
D07119
DB00630
Fosamax
Fosamax Plus D
HSCI1_000337
LS-106421
MK 217
MK-217
MolPort-000-421-410
NCGC00096054-01
NCGC00096054-03
NCGC00096054-04
Onclast
Oprea1_422906
Phosphonic acid, (4-amino-1-hydroxybutylidene)bis
SPECTRUM1505166
ST50036159
UNII-X1J18R4W8P
alendronate
bisphosphonate, 65
10
Etanerceptapproved, investigationalPhase 3383185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
11Peripheral Nervous System AgentsPhase 318510
12Gamma-GlobulinsPhase 322
13Immunoglobulins, IntravenousPhase 3211
14Rho(D) Immune GlobulinPhase 3206
15Anti-Inflammatory Agents, Non-SteroidalPhase 33549
16Interleukin 1 Receptor Antagonist ProteinPhase 2, Phase 335
17Antirheumatic AgentsPhase 2, Phase 38496
18AnalgesicsPhase 39358
19Analgesics, Non-NarcoticPhase 35184
20Anti-Inflammatory AgentsPhase 38478
21glucocorticoidsPhase 2, Phase 33896
22Bone Density Conservation AgentsPhase 2, Phase 32600
23Gastrointestinal AgentsPhase 36401
24Immunosuppressive AgentsPhase 310422
25tannic acidNutraceuticalPhase 31684
26Histone Deacetylase InhibitorsPhase 2532
27Givinostat hydrochloridePhase 211
28Pharmaceutical SolutionsPhase 17004

Interventional clinical trials:

(show all 30)
idNameStatusNCT IDPhase
1A Study of Decreased Dose Frequency in Participants With Systemic Juvenile Arthritis Who Experience Laboratory Abnormalities During Treatment With RoActemra/Actemra (Tocilizumab)RecruitingNCT01734382Phase 4
2a Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis Who Participated in the Study CACZ885G2301E1Active, not recruitingNCT02334748Phase 4
3Interleukin-1 Receptor Antagonist (IL-1RA) (ANAKINRA) IN SEVERE SYSTEMIC-ONSET JUVENILE IDIOPATHIC ARTHRITISCompletedNCT00339157Phase 2, Phase 3
4An Open-label Extension Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis and Active Systemic Manifestations Manifestations and Response Characterization Study in Canakinumab Treatment-naïve Patients With Active SJIA With and WiCompletedNCT00891046Phase 3
5Flare Prevention Study of Canakinumab in Patients With Active Systemic Juvenile Idiopathic Arthritis (SJIA)CompletedNCT00889863Phase 3
6A Study of RoActemra/Actemra (Tocilizumab) in Patients With Active Systemic Juvenile Idiopathic Arthritis (JIA)CompletedNCT00642460Phase 3
7Study of MRA for Systemic Juvenile Idiopathic Arthritis (sJIA)CompletedNCT00144599Phase 3
8Long-term Treatment Study of MRA for Systemic Juvenile Idiopathic Arthritis (sJIA)CompletedNCT00144612Phase 3
9Study of MRA for Polyarticular Juvenile Idiopathic Arthritis (pJIA)CompletedNCT00144664Phase 3
10Treatment of Childhood Onset Psychiatric Disorders With Intravenous Immunoglobulin (IVIg)CompletedNCT00001768Phase 3
11Study of Efficacy and Safety of Canakinumab in Japanese Patients With SJIARecruitingNCT02396212Phase 3
12ß-SPECIFIC 4 Patients: Study of Pediatric EffiCacy and Safety wIth FIrst-line Use of CanakinumabRecruitingNCT02296424Phase 3
13Alendronate Osteoporosis StudyActive, not recruitingNCT00277251Phase 2, Phase 3
14Safety and Efficacy Study of Etanercept (Enbrel®) In Children With Systemic Onset Juvenile Rheumatoid ArthritisTerminatedNCT00078806Phase 3
15Single-dose Study to Assess Efficacy of Canakinumab (ACZ885) in Patients With Active Juvenile Idiopathic Arthritis (SJIA)TerminatedNCT00886769Phase 3
16An Open-label, Multi-arm, Non-comparative Safety and Tolerability Study of Canakinumab (ACZ885) in Patients With Active Systemic Juvenile Idiopathic Arthritis (SJIA)WithdrawnNCT01676948Phase 3
17Phase II, Open Label, International, Multicentre Clinical Trial to Investigate Safety and Efficacy of Oral ITF2357 in Patients With Active Systemic Onset Juvenile Idiopathic Arthritis (SOJIA)CompletedNCT00570661Phase 2
18Safety and Effectiveness of Rilonacept for Treating Systemic Juvenile Idiopathic Arthritis in Children and Young AdultsCompletedNCT00534495Phase 2
19Safety, Efficacy and Pharmacokinetics of Subcutaneous ACZ885 in Patients With Systemic Juvenile Idiopathic Arthritis (SJIA)CompletedNCT00426218Phase 1, Phase 2
20Ilaris (Canakinumab) in the Schnitzler SyndromeCompletedNCT01245127Phase 2
21Study to Evaluate the Safety and Tolerability of Two Doses of Rilonacept in Pediatric Subjects With Active Systemic Juvenile Idiopathic Arthritis (SJIA)CompletedNCT01803321Phase 1
22An Open-Label Trial of Tocilizumab in SchizophreniaCompletedNCT01696929Phase 1
23A Study of RoActemra/Actemra (Tocilizumab) in Patients Less Than 2 Years Old With Active Systemic Juvenile Idiopathic ArthritisRecruitingNCT01455701Phase 1
24A Study of Subcutaneously Administered Tocilizumab in Participants With Systemic Juvenile Idiopathic ArthritisRecruitingNCT01904292Phase 1
25Extension Study Evaluating the Safety and Efficacy of Subcutaneous RoActemra/Actemra Administration in Patients With Systemic and Polyarticular-Course Juvenile Idiopathic ArthritisRecruitingNCT02165345Phase 1
26Ultrasonography in Juvenile Idiopathic ArthritisCompletedNCT01304420Phase 0
27The CARRA RegistryCompletedNCT01697254
28Observational Study of Pediatric Rheumatic Diseases: The CARRA RegistryRecruitingNCT02418442
29New Candidate Criteria for Diagnosis of Macrophage Activation SyndromeEnrolling by invitationNCT01095146
30Single Patient Use of Tocilizumab in Systemic Onset Juvenile Idiopathic ArthritisTerminatedNCT00868751

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Genetic Tests for Systemic Onset Juvenile Idiopathic Arthritis

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Anatomical Context for Systemic Onset Juvenile Idiopathic Arthritis

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MalaCards organs/tissues related to Systemic Onset Juvenile Idiopathic Arthritis:

33
Bone, Liver, Thyroid, T cells, Skin, Heart, Prostate

Animal Models for Systemic Onset Juvenile Idiopathic Arthritis or affiliated genes

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MGI Mouse Phenotypes related to Systemic Onset Juvenile Idiopathic Arthritis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6IL1R1, IL6, MIF, PRF1, TNF
2MP:00053708.5IL1R1, IL6, MEFV, PRF1, TNF
3MP:00107717.9IL1R1, IL1RN, IL6, MEFV, PRF1, TNF
4MP:00053907.2IL1R1, IL1RN, IL6, MEFV, SLC26A2, TNF
5MP:00053877.1IL1R1, IL1RN, IL6, MEFV, MIF, PRF1
6MP:00053976.9IL1R1, IL1RN, IL6, MEFV, MIF, PRF1
7MP:00053786.8IL1R1, IL1RN, IL6, MEFV, PRF1, SLC26A2
8MP:00053846.6IL1R1, IL1RN, IL6, MEFV, MIF, PRF1

Publications for Systemic Onset Juvenile Idiopathic Arthritis

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Articles related to Systemic Onset Juvenile Idiopathic Arthritis:

(show top 50)    (show all 109)
idTitleAuthorsYear
1
Myositis as a presenting feature of systemic onset juvenile idiopathic arthritis. (25677488)
2015
2
Potential Effects of Interleukins on the Pathogenesis of Systemic Onset Juvenile Idiopathic Arthritis. (26810447)
2015
3
Soluble CD25 in serum: a potential marker for subclinical macrophage activation syndrome in patients with active systemic onset juvenile idiopathic arthritis. (24417800)
2014
4
Pathogenesis of systemic inflammatory diseases in childhood: "Lessons from clinical trials of anti-cytokine monoclonal antibodies for Kawasaki disease, systemic onset juvenile idiopathic arthritis, and cryopyrin-associated periodic fever syndrome" (24842480)
2014
5
A130: Is the CCR5-delta32 Mutation Protective Against Systemic-Onset Juvenile Idiopathic Arthritis? (24677884)
2014
6
Atopy in children with systemic onset juvenile idiopathic arthritis (SoJIA) is associated with a worse outcome. (24611751)
2014
7
AA amyloidosis associated with systemic-onset juvenile idiopathic arthritis. (23664546)
2013
8
Anakinra pharmacokinetics in children and adolescents with systemic-onset juvenile idiopathic arthritis and autoinflammatory syndromes. (23915458)
2013
9
Congestive heart failure: an uncommon presentation of systemic onset juvenile idiopathic arthritis (SOJIA). (22161583)
2013
10
Macrophage activation syndrome in children with systemic onset juvenile idiopathic arthritis: clinical experience from northwest India. (21221591)
2012
11
Leflunomide in systemic onset Juvenile idiopathic arthritis. (23024081)
2012
12
Anakinra: a safe and effective first-line treatment in systemic onset juvenile idiopathic arthritis (SoJIA). (22083619)
2012
13
Development of germinoma during the treatment of systemic-onset juvenile idiopathic arthritis with infliximab. (22072226)
2012
14
A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial). (21173013)
2011
15
De novo 19q13.42 duplications involving NLRP gene cluster in a patient with systemic-onset juvenile idiopathic arthritis. (21326309)
2011
16
IL10 promoter polymorphisms are associated with systemic onset juvenile idiopathic arthritis (SoJIA). (21205466)
2010
17
Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis. (20019066)
2010
18
Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis. (20472718)
2010
19
Peripheral ulcerative keratitis in a patient with systemic-onset juvenile idiopathic arthritis. (21162464)
2010
20
Incomplete Kawasaki syndrome followed by systemic onset-juvenile idiopathic arthritis mimicking Kawasaki syndrome. (19455336)
2010
21
Bicipital synovial cyst in systemic-onset juvenile idiopathic arthritis. (20338579)
2010
22
Perioperative anesthetic concerns in a child with systemic onset juvenile idiopathic arthritis syndrome. (20670244)
2010
23
Fever of unknown origin in a patient of systemic onset juvenile idiopathic arthritis. (22918076)
2010
24
Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis. (19714583)
2009
25
Macrophage activation syndrome in an inadequately treated patient with systemic onset juvenile idiopathic arthritis. (20502084)
2009
26
Rituximab therapy for refractory systemic-onset juvenile idiopathic arthritis. (19286909)
2009
27
The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleukin-1beta form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritis. (19248102)
2009
28
Nodulosis in systemic onset juvenile idiopathic arthritis: an uncommon event with spontaneous resolution. (19840317)
2009
29
Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis. (18311812)
2008
30
Macrophage activation syndrome in 13 children with systemic-onset juvenile idiopathic arthritis. (18661762)
2008
31
Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: preliminary experience in France. (17947302)
2008
32
Systemic onset juvenile idiopathic arthritis--its unusual presentation. (18536898)
2008
33
Is tocilizumab a good therapeutic option for RA and systemic-onset juvenile idiopathic arthritis? (18779846)
2008
34
Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial. (18358927)
2008
35
Large pericardial effusion requiring pericardiocentesis as cardinal sign of macrophage activation syndrome in systemic onset-juvenile idiopathic arthritis. (17160383)
2007
36
Treatment of difficult cases of systemic-onset juvenile idiopathic arthritis with tacrolimus. (17187256)
2007
37
Failure to distinguish systemic-onset juvenile idiopathic arthritis from incomplete Kawasaki disease in an infant. (17854457)
2007
38
Systemic lupus erythematosus with major organ involvement in a patient with systemic-onset juvenile idiopathic arthritis. (17407252)
2007
39
Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade. (17724127)
2007
40
Systemic onset juvenile idiopathic arthritis: update on pathogenesis and treatment. (20477675)
2007
41
Developing a disease activity tool for systemic-onset juvenile idiopathic arthritis by international consensus using the Delphi approach. (16159950)
2005
42
Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis. (15751095)
2005
43
Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade. (15851489)
2005
44
Does systemic-onset juvenile idiopathic arthritis belong under juvenile idiopathic arthritis? (15956091)
2005
45
Coronary artery dilation among patients presenting with systemic-onset juvenile idiopathic arthritis. (15930186)
2005
46
Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis. (12746913)
2003
47
Infliximab for systemic onset juvenile idiopathic arthritis: experience in 3 children. (12022340)
2002
48
Systemic onset juvenile idiopathic arthritis: a retrospective study of 80 consecutive patients followed for 10 years. (11196535)
2001
49
Macrophage activation syndrome as the initial manifestation of systemic onset juvenile idiopathic arthritis. (11791663)
2001
50

Variations for Systemic Onset Juvenile Idiopathic Arthritis

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Expression for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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LifeMap Discovery
Genes differentially expressed in tissues of Systemic Onset Juvenile Idiopathic Arthritis patients vs. healthy controls: 32 (show all 6)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1PRTN3proteinase 3Blood+3.610.000
2AZU1azurocidin 1Blood+3.540.000
3MPOmyeloperoxidaseBlood+3.340.000
4ELANEelastase, neutrophil expressedBlood+3.310.000
5DEFA4defensin, alpha 4, corticostatinBlood+3.240.000
6GPER1G protein-coupled estrogen receptor 1Blood+3.070.000

Search GEO for disease gene expression data for Systemic Onset Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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Pathways related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathwaysScoreTop Affiliating Genes
19.5IL6, TNF
29.5IL6, TNF
39.5IL6, TNF
49.1IL6, MIF, TNF
59.1IL6, MIF, TNF
69.1IL1R1, IL6, TNF
7
Show member pathways
9.1IL1R1, IL6, TNF
89.1IL1R1, IL6, TNF
9
Show member pathways
9.0IL6, MEFV, TNF
109.0IL1RN, IL6, TNF
11
Show member pathways
8.7IL1R1, IL6, MIF, TNF
128.7IL1R1, IL6, MIF, TNF
13
Show member pathways
8.5IL1R1, IL1RN, IL6, TNF

GO Terms for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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Biological processes related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.0IL6, TNF
2positive regulation of cytokine secretionGO:005071510.0MIF, TNF
3positive regulation of nitric oxide biosynthetic processGO:004542910.0IL6, TNF
4positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:20003439.9MIF, TNF
5acute-phase responseGO:00069539.9IL1RN, IL6
6negative regulation of lipid storageGO:00108889.8IL6, TNF
7negative regulation of fat cell differentiationGO:00455999.8IL6, TNF
8positive regulation of interleukin-6 productionGO:00327559.4IL6, TNF
9positive regulation of peptidyl-serine phosphorylationGO:00331389.3IL6, MIF, TNF
10inflammatory responseGO:00069549.1IL6, MIF, TNF

Sources for Systemic Onset Juvenile Idiopathic Arthritis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet