MCID: SYS034
MIFTS: 47

Systemic Onset Juvenile Idiopathic Arthritis malady

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Systemic Onset Juvenile Idiopathic Arthritis

Aliases & Descriptions for Systemic Onset Juvenile Idiopathic Arthritis:

Name: Systemic Onset Juvenile Idiopathic Arthritis 50
Systemic Onset Juvenile Rheumatoid Arthritis 50
Systemic Onset Juvenile Chronic Arthritis 69
Systemic Juvenile Idiopathic Arthritis 50

Classifications:



Summaries for Systemic Onset Juvenile Idiopathic Arthritis

MalaCards based summary : Systemic Onset Juvenile Idiopathic Arthritis, also known as systemic onset juvenile rheumatoid arthritis, is related to macrophage activation syndrome and rheumatoid arthritis, systemic juvenile. An important gene associated with Systemic Onset Juvenile Idiopathic Arthritis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Allograft rejection. The drugs Liver Extracts and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, liver and b cells, and related phenotypes are hematopoietic system and immune system

Related Diseases for Systemic Onset Juvenile Idiopathic Arthritis

Diseases related to Systemic Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
id Related Disease Score Top Affiliating Genes
1 macrophage activation syndrome 11.4
2 rheumatoid arthritis, systemic juvenile 11.2
3 arthritis 10.8
4 kawasaki disease 10.3
5 intussusception 10.2 IL1B TNF
6 myeloid neoplasms associated with pdgfrb rearrangement 10.2 MEFV TNF
7 candidiasis, familial, 4, autosomal recessive 10.2 MEFV TNF
8 stocco dos santos syndrome 10.2 IL1B TNF
9 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.2 IL1B TNF
10 twin-to-twin transfusion syndrome 10.2 IL1B TNF
11 warthin tumor 10.2 IL1B TNF
12 anal paget's disease 10.2 IL1B TNF
13 tetanus 10.2 MEFV TNF
14 cataract 10.2 IL1B TNF
15 hepatic encephalopathy 10.2 IL1B TNF
16 mechanical lagophthalmos 10.2 MEFV TNF
17 bipolar i disorder 10.2 IL1B TNF
18 human immunodeficiency virus infectious disease 10.2 IL1B TNF
19 cerebellar disease 10.2 IL1B TNF
20 tinea capitis 10.2 IL1B TNF
21 amyotrophic lateral sclerosis type 14 10.2 IL1B TNF
22 measles 10.2 IL1B TNF
23 parkinson disease 11 10.2 IL1B TNF
24 dextrocardia 10.2 IL1B TNF
25 hypoparathyroidism-retardation-dysmorphism syndrome 10.2 IL1B TNF
26 gastroduodenal crohn's disease 10.2 IL1B TNF
27 childhood endodermal sinus tumor 10.2 IL1B TNF
28 dermatomycosis 10.2 MEFV TNF
29 mikulicz disease 10.2 IL1B TNF
30 senile reticular retinal degeneration 10.2 IL1B TNF
31 malignant histiocytosis 10.2 MEFV TNF
32 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.2 IL1B TNF
33 ectodermal dysplasia bartalos type 10.2 IL1B TNF
34 mineral metabolism disease 10.2 IL1B TNF
35 migraine with aura 10.2 IL1B TNF
36 histiocytoma 10.2 MEFV TNF
37 rickettsialpox 10.2 IL1B TNF
38 autosomal recessive type iv ehlers-danlos syndrome 10.2 IL1B TNF
39 bladder signet ring cell adenocarcinoma 10.2 IL1B TNF
40 neuropathy 10.2 IL1B TNF
41 muckle-wells syndrome 10.2 IL1B MEFV
42 retinal cancer 10.2 IL1B MEFV
43 keratoconus 10.2 IL1B TNF
44 motility-related diarrhea 10.2 IL1B TNF
45 splenic artery aneurysm 10.2 IL1B TNF
46 urticaria 10.2 IL1B TNF
47 wound botulism 10.2 IL1B TNF
48 strawberry gallbladder 10.2 MEFV TNF
49 ovarian cystic teratoma 10.2 IL1B TNF
50 central nervous system lymphoma 10.2 IL1B TNF

Graphical network of the top 20 diseases related to Systemic Onset Juvenile Idiopathic Arthritis:



Diseases related to Systemic Onset Juvenile Idiopathic Arthritis

Symptoms & Phenotypes for Systemic Onset Juvenile Idiopathic Arthritis

MGI Mouse Phenotypes related to Systemic Onset Juvenile Idiopathic Arthritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.55 MEFV PRF1 TNF IL18 IL1B
2 immune system MP:0005387 9.35 MEFV PRF1 TNF IL18 IL1B
3 integument MP:0010771 9.02 MEFV PRF1 TNF IL18 IL1B

Drugs & Therapeutics for Systemic Onset Juvenile Idiopathic Arthritis

Drugs for Systemic Onset Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts Phase 4
2
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
3
Alendronate Approved Phase 2, Phase 3 121268-17-5, 66376-36-1 2088
4
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
5
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
6
Tofacitinib Approved, Investigational Phase 3 477600-75-2
7
Etanercept Approved, Investigational Phase 3 185243-69-0
8
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
9 tannic acid Approved, Nutraceutical Phase 3
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
11 Analgesics Phase 3
12 glucocorticoids Phase 2, Phase 3
13 Folic Acid Antagonists Phase 3
14 Nucleic Acid Synthesis Inhibitors Phase 3
15 Analgesics, Non-Narcotic Phase 3
16 Dermatologic Agents Phase 3
17 Peripheral Nervous System Agents Phase 3
18 Vitamin B Complex Phase 3
19 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1
20 Immunoglobulins Phase 3,Phase 1,Phase 2
21 gamma-Globulins Phase 3
22 Immunoglobulins, Intravenous Phase 3
23 Antibodies, Monoclonal Phase 3,Phase 1,Phase 2
24 Immunosuppressive Agents Phase 3
25 Anti-Inflammatory Agents Phase 3
26 Interleukin 1 Receptor Antagonist Protein Phase 2, Phase 3
27 Anti-Inflammatory Agents, Non-Steroidal Phase 3
28 Antimetabolites Phase 3
29 Antimetabolites, Antineoplastic Phase 3
30 Rho(D) Immune Globulin Phase 3
31 Antibodies Phase 3,Phase 1,Phase 2
32 Antirheumatic Agents Phase 2, Phase 3
33 Bone Density Conservation Agents Phase 2, Phase 3
34 Protein Kinase Inhibitors Phase 3
35 Gastrointestinal Agents Phase 3
36 Folate Nutraceutical Phase 3
37 Vitamin B9 Nutraceutical Phase 3
38 Givinostat hydrochloride Phase 2
39 Histone Deacetylase Inhibitors Phase 2
40 Rheumatoid Factor

Interventional clinical trials:

(show all 34)
id Name Status NCT ID Phase
1 A Study of Decreased Dose Frequency in Participants With Systemic Juvenile Arthritis Who Experience Laboratory Abnormalities During Treatment With RoActemra/Actemra (Tocilizumab) Recruiting NCT01734382 Phase 4
2 Interleukin-1 Receptor Antagonist (IL-1RA) (ANAKINRA) IN SEVERE SYSTEMIC-ONSET JUVENILE IDIOPATHIC ARTHRITIS Completed NCT00339157 Phase 2, Phase 3
3 An Open-label Extension Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis and Active Systemic Manifestations Manifestations and Response Characterization Study in Canakinumab Treatment-naïve Patients With Active SJIA With and Wi Completed NCT00891046 Phase 3
4 Flare Prevention Study of Canakinumab in Patients With Active Systemic Juvenile Idiopathic Arthritis (SJIA) Completed NCT00889863 Phase 3
5 A Study of RoActemra/Actemra (Tocilizumab) in Patients With Active Systemic Juvenile Idiopathic Arthritis (JIA) Completed NCT00642460 Phase 3
6 Study of MRA for Systemic Juvenile Idiopathic Arthritis (sJIA) Completed NCT00144599 Phase 3
7 Long-term Treatment Study of MRA for Systemic Juvenile Idiopathic Arthritis (sJIA) Completed NCT00144612 Phase 3
8 Alendronate Osteoporosis Study Completed NCT00277251 Phase 2, Phase 3
9 Study of MRA for Polyarticular Juvenile Idiopathic Arthritis (pJIA) Completed NCT00144664 Phase 3
10 Treatment of Childhood Onset Psychiatric Disorders With Intravenous Immunoglobulin (IVIg) Completed NCT00001768 Phase 3
11 A Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis or Hereditary Periodic Fevers Who Participated in the CACZ885G2301E1, CACZ885G2306 or CACZ885N2301 Studies Recruiting NCT02334748 Phase 3
12 ß-SPECIFIC 4 Patients: Study of Pediatric EffiCacy and Safety wIth FIrst-line Use of Canakinumab Recruiting NCT02296424 Phase 3
13 Study of Efficacy and Safety of Canakinumab in Japanese Patients With SJIA Active, not recruiting NCT02396212 Phase 3
14 A Safety, Efficacy And Pharmacokinetics Study Of Tofacitinib In Pediatric Patients With sJIA Not yet recruiting NCT03000439 Phase 3
15 Safety and Efficacy Study of Etanercept (Enbrel®) In Children With Systemic Onset Juvenile Rheumatoid Arthritis Terminated NCT00078806 Phase 3
16 Single-dose Study to Assess Efficacy of Canakinumab (ACZ885) in Patients With Active Juvenile Idiopathic Arthritis (SJIA) Terminated NCT00886769 Phase 3
17 An Open-label, Multi-arm, Non-comparative Safety and Tolerability Study of Canakinumab (ACZ885) in Patients With Active Systemic Juvenile Idiopathic Arthritis (SJIA) Withdrawn NCT01676948 Phase 3
18 Phase II, Open Label, International, Multicentre Clinical Trial to Investigate Safety and Efficacy of Oral ITF2357 in Patients With Active Systemic Onset Juvenile Idiopathic Arthritis (SOJIA) Completed NCT00570661 Phase 2
19 Safety and Effectiveness of Rilonacept for Treating Systemic Juvenile Idiopathic Arthritis in Children and Young Adults Completed NCT00534495 Phase 2
20 Safety, Efficacy and Pharmacokinetics of Subcutaneous ACZ885 in Patients With Systemic Juvenile Idiopathic Arthritis (SJIA) Completed NCT00426218 Phase 1, Phase 2
21 Ilaris (Canakinumab) in the Schnitzler Syndrome Completed NCT01245127 Phase 2
22 A Repeated Dose-finding Study of Sarilumab in Children and Adolescents With Systemic Juvenile Idiopathic Arthritis (sJIA) Recruiting NCT02991469 Phase 2
23 Tocilizumab in Patients With Schnitzler's Syndrome Not yet recruiting NCT03046381 Phase 2
24 Study to Evaluate the Safety and Tolerability of Two Doses of Rilonacept in Pediatric Subjects With Active Systemic Juvenile Idiopathic Arthritis (SJIA) Completed NCT01803321 Phase 1
25 An Open-Label Trial of Tocilizumab in Schizophrenia Completed NCT01696929 Phase 1
26 Extension Study Evaluating the Safety and Efficacy of Subcutaneous Tocilizumab (RoActemra/Actemra) Administration in Systemic and Polyarticular-Course Juvenile Idiopathic Arthritis Recruiting NCT02165345 Phase 1
27 A Study to Evaluate the Pharmacokinetic and Safety of Tocilizumab (RoActemra/Actemra) in Participants Less Than 2 Years Old With Active Systemic Juvenile Idiopathic Arthritis Active, not recruiting NCT01455701 Phase 1
28 A Study of Subcutaneously Administered Tocilizumab in Participants With Systemic Juvenile Idiopathic Arthritis Active, not recruiting NCT01904292 Phase 1
29 Tocilizumab in Schizophrenia Not yet recruiting NCT02874573 Phase 1
30 New Candidate Criteria for Diagnosis of Macrophage Activation Syndrome Unknown status NCT01095146
31 Ultrasonography in Juvenile Idiopathic Arthritis Completed NCT01304420 Early Phase 1
32 The CARRA Registry Completed NCT01697254
33 Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry Recruiting NCT02418442
34 Single Patient Use of Tocilizumab in Systemic Onset Juvenile Idiopathic Arthritis Terminated NCT00868751

Search NIH Clinical Center for Systemic Onset Juvenile Idiopathic Arthritis

Genetic Tests for Systemic Onset Juvenile Idiopathic Arthritis

Anatomical Context for Systemic Onset Juvenile Idiopathic Arthritis

MalaCards organs/tissues related to Systemic Onset Juvenile Idiopathic Arthritis:

39
Neutrophil, Liver, B Cells, Myeloid, Heart

Publications for Systemic Onset Juvenile Idiopathic Arthritis

Articles related to Systemic Onset Juvenile Idiopathic Arthritis:

(show top 50) (show all 113)
id Title Authors Year
1
Operative stabilization of the remaining mobile segment in ankylosed cervical spine in systemic onset - juvenile idiopathic arthritis: A case report. ( 27458558 )
2016
2
Systemic-onset juvenile idiopathic arthritis or incomplete Kawasaki disease: a diagnostic challenge. ( 27782865 )
2016
3
Systemic-onset juvenile idiopathic arthritis. ( 27392503 )
2016
4
IL-6 blockers in systemic onset juvenile idiopathic arthritis. ( 26642378 )
2016
5
Assessment of vascular function in systemic onset juvenile idiopathic arthritis. ( 27075461 )
2016
6
Should 2016 Criteria for Macrophage Activation Syndrome be applied in children with Kawasaki disease, as well as with systemic-onset juvenile idiopathic arthritis? ( 26965982 )
2016
7
Systemic onset juvenile idiopathic arthritis and exposure to fine particulate air pollution. ( 27607024 )
2016
8
Myositis as a presenting feature of systemic onset juvenile idiopathic arthritis. ( 25677488 )
2015
9
Successful treatment with tocilizumab every 4A weeks of a low disease activity group who achieve a drug-free remission in patients with systemic-onset juvenile idiopathic arthritis. ( 25685108 )
2015
10
Bullous Erythema Nodosum Leprosum masquerading as systemic onset juvenile idiopathic arthritis: A case report. ( 26964436 )
2015
11
Systemic onset juvenile idiopathic arthritis with macrophage activation syndrome and coronary artery dilatation misdiagnosed as Kawasaki disease. ( 27411422 )
2015
12
Diagnosis of Systemic-Onset Juvenile Idiopathic Arthritis after Treatment for Presumed Kawasaki Disease. ( 25771391 )
2015
13
Successful treatment of macrophage activation syndrome due to systemic onset juvenile idiopathic arthritis with antithymocyte globulin. ( 26210998 )
2015
14
Reversible posterior leukoencephalopathy syndrome secondary to systemic-onset juvenile idiopathic arthritis: A case report and review of the literature. ( 25469247 )
2015
15
Effect of etanercept on refractory systemic-onset juvenile idiopathic arthritis. ( 25754755 )
2015
16
Potential Effects of Interleukins on the Pathogenesis of Systemic Onset Juvenile Idiopathic Arthritis. ( 26810447 )
2015
17
A safety evaluation of canakinumab for the treatment of systemic onset juvenile idiopathic arthritis. ( 26568054 )
2015
18
A130: Is the CCR5-delta32 Mutation Protective Against Systemic-Onset Juvenile Idiopathic Arthritis? ( 24677884 )
2014
19
Discrepancy between clinical and radiological responses to tocilizumab treatment in patients with systemic-onset juvenile idiopathic arthritis. ( 24786929 )
2014
20
Soluble CD25 in serum: a potential marker for subclinical macrophage activation syndrome in patients with active systemic onset juvenile idiopathic arthritis. ( 24417800 )
2014
21
Coronary artery abnormalities in children with systemic-onset juvenile idiopathic arthritis. ( 24793086 )
2014
22
Atopy in children with systemic onset juvenile idiopathic arthritis (SoJIA) is associated with a worse outcome. ( 24611751 )
2014
23
MEFV mutations in egyptian children with systemic-onset juvenile idiopathic arthritis. ( 24862656 )
2014
24
Pathogenesis of systemic inflammatory diseases in childhood: "Lessons from clinical trials of anti-cytokine monoclonal antibodies for Kawasaki disease, systemic onset juvenile idiopathic arthritis, and cryopyrin-associated periodic fever syndrome" ( 24842480 )
2014
25
Systemic onset juvenile idiopathic arthritis with macrophage activation syndrome misdiagnosed as Kawasaki disease: case report and literature review. ( 21132551 )
2013
26
Congestive heart failure: an uncommon presentation of systemic onset juvenile idiopathic arthritis (SOJIA). ( 22161583 )
2013
27
Systemic-onset juvenile idiopathic arthritis and HLA-B27 juvenile-onset undifferentiated spondyloarthritis in the same patient. ( 23295075 )
2013
28
Anakinra pharmacokinetics in children and adolescents with systemic-onset juvenile idiopathic arthritis and autoinflammatory syndromes. ( 23915458 )
2013
29
AA amyloidosis associated with systemic-onset juvenile idiopathic arthritis. ( 23664546 )
2013
30
Thalidomide for systemic onset juvenile idiopathic arthritis. ( 23474929 )
2013
31
Incomplete Kawasaki disease followed by systemic onset juvenile idiopathic arthritis- the diagnostic dilemma. ( 23054859 )
2013
32
Nodular regenerative hyperplasia of the liver as a complication of long-standing systemic-onset juvenile idiopathic arthritis. ( 24315465 )
2013
33
Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist. ( 22490470 )
2012
34
Systemic-onset juvenile idiopathic arthritis: the changing life of a rare disease. ( 22573189 )
2012
35
Development of germinoma during the treatment of systemic-onset juvenile idiopathic arthritis with infliximab. ( 22072226 )
2012
36
Anakinra: a safe and effective first-line treatment in systemic onset juvenile idiopathic arthritis (SoJIA). ( 22083619 )
2012
37
Macrophage activation syndrome in children with systemic onset juvenile idiopathic arthritis: clinical experience from northwest India. ( 21221591 )
2012
38
ANCA-associated glomerulonephritis in systemic-onset juvenile idiopathic arthritis. ( 22189036 )
2012
39
Acute liver failure in young children with systemic-onset juvenile idiopathic arthritis without macrophage activation syndrome: report of two cases. ( 22050445 )
2012
40
Pure red cell aplasia in systemic onset juvenile idiopathic arthritis. ( 23448798 )
2012
41
The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis. ( 22267331 )
2012
42
Recurrent cardiac tamponade in a child with newly diagnosed systemic-onset juvenile idiopathic arthritis. ( 22955481 )
2012
43
Systemic-onset juvenile idiopathic arthritis complicated by early onset amyloidosis in a patient carrying a mutation in the MEFV gene. ( 20044784 )
2012
44
Initial manifestations and clinical course of systemic onset juvenile idiopathic arthritis: a ten-year retrospective study. ( 23089689 )
2012
45
Safety and response to influenza vaccine in patients with systemic-onset juvenile idiopathic arthritis receiving tocilizumab. ( 22322589 )
2012
46
Leflunomide in systemic onset Juvenile idiopathic arthritis. ( 23024081 )
2012
47
Renal cell carcinoma and systemic onset juvenile idiopathic arthritis. ( 23250291 )
2011
48
De novo 19q13.42 duplications involving NLRP gene cluster in a patient with systemic-onset juvenile idiopathic arthritis. ( 21326309 )
2011
49
[Case of systemic-onset juvenile idiopathic arthritis complicated with sepsis --usefulness of cytokine profile for the differentiation between macrophage activation syndrome and sepsis]. ( 21628853 )
2011
50
Cardiac tamponade in a child with systemic-onset juvenile idiopathic arthritis: dramatic improvement after interleukin-1 blockade by anakinra. ( 21544583 )
2011

Variations for Systemic Onset Juvenile Idiopathic Arthritis

Expression for Systemic Onset Juvenile Idiopathic Arthritis

LifeMap Discovery
Genes differentially expressed in tissues of Systemic Onset Juvenile Idiopathic Arthritis patients vs. healthy controls: 35
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1 PRTN3 proteinase 3 Blood + 3.61 0.000
2 AZU1 azurocidin 1 Blood + 3.54 0.000
3 MPO myeloperoxidase Blood + 3.34 0.000
4 ELANE elastase, neutrophil expressed Blood + 3.31 0.000
5 DEFA4 defensin, alpha 4, corticostatin Blood + 3.24 0.000
6 GPER1 G protein-coupled estrogen receptor 1 Blood + 3.07 0.000
Search GEO for disease gene expression data for Systemic Onset Juvenile Idiopathic Arthritis.

Pathways for Systemic Onset Juvenile Idiopathic Arthritis

Pathways related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 37)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.69 IL18 IL1B MEFV TNF
2
Show member pathways
12.58 IL1B PRF1 TNF
3
Show member pathways
12.53 IL18 IL1B TNF
4
Show member pathways
12.46 IL18 IL1B TNF
5
Show member pathways
12.34 IL18 IL1B TNF
6
Show member pathways
12.33 IL18 IL1B TNF
7 11.99 IL18 IL1B TNF
8
Show member pathways
11.92 IL18 IL1B TNF
9 11.76 IL18 IL1B TNF
10
Show member pathways
11.72 IL18 IL1B TNF
11 11.61 IL18 IL1B
12 11.61 IL18 IL1B TNF
13 11.55 IL1B TNF
14 11.55 IL1B TNF
15 11.54 IL18 IL1B TNF
16 11.45 IL1B TNF
17
Show member pathways
11.45 IL1B TNF
18
Show member pathways
11.43 PRF1 TNF
19 11.35 IL18 IL1B TNF
20 11.32 IL1B TNF
21 11.29 IL1B TNF
22 11.27 IL18 IL1B TNF
23
Show member pathways
11.26 IL1B TNF
24 11.23 IL18 IL1B TNF
25 11.18 IL18 IL1B TNF
26 11.16 IL1B TNF
27 11.1 IL1B TNF
28 11.08 IL1B TNF
29 11.05 IL18 IL1B MEFV
30 11.04 IL18 PRF1
31 10.98 IL18 IL1B
32 10.98 IL18 IL1B TNF
33 10.88 IL18 IL1B TNF
34 10.77 IL1B TNF
35 10.64 IL18 IL1B TNF
36 10.34 IL18 IL1B
37 10.14 IL18 IL1B TNF

GO Terms for Systemic Onset Juvenile Idiopathic Arthritis

Biological processes related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 28)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.81 IL18 IL1B TNF
2 MAPK cascade GO:0000165 9.75 IL18 IL1B TNF
3 inflammatory response GO:0006954 9.71 IL18 IL1B MEFV TNF
4 positive regulation of protein kinase B signaling GO:0051897 9.64 IL18 TNF
5 regulation of insulin secretion GO:0050796 9.63 IL1B TNF
6 positive regulation of JNK cascade GO:0046330 9.62 IL1B TNF
7 positive regulation of smooth muscle cell proliferation GO:0048661 9.62 IL18 TNF
8 positive regulation of interleukin-6 production GO:0032755 9.61 IL1B TNF
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.61 IL1B TNF
10 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.6 IL1B TNF
11 protein kinase B signaling GO:0043491 9.59 IL1B TNF
12 positive regulation of phagocytosis GO:0050766 9.58 IL1B TNF
13 positive regulation of interleukin-8 production GO:0032757 9.57 IL1B TNF
14 negative regulation of myoblast differentiation GO:0045662 9.56 IL18 TNF
15 negative regulation of lipid catabolic process GO:0050995 9.55 IL1B TNF
16 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.54 IL1B TNF
17 cellular response to organic cyclic compound GO:0071407 9.54 IL18 IL1B TNF
18 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.52 IL1B TNF
19 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.51 IL1B TNF
20 positive regulation of chemokine biosynthetic process GO:0045080 9.49 IL1B TNF
21 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.48 IL18 IL1B
22 regulation of establishment of endothelial barrier GO:1903140 9.46 IL1B TNF
23 positive regulation of fever generation GO:0031622 9.43 IL1B TNF
24 positive regulation of interferon-gamma production GO:0032729 9.33 IL18 IL1B TNF
25 sequestering of triglyceride GO:0030730 9.32 IL1B TNF
26 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 IL1B TNF
27 lipopolysaccharide-mediated signaling pathway GO:0031663 9.13 IL18 IL1B TNF
28 positive regulation of NF-kappaB import into nucleus GO:0042346 8.8 IL18 IL1B TNF

Molecular functions related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IL18 IL1B TNF

Sources for Systemic Onset Juvenile Idiopathic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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