MCID: SYS034
MIFTS: 59

Systemic Onset Juvenile Idiopathic Arthritis malady

Rare diseases, Respiratory diseases, Bone diseases categories

Aliases & Classifications for Systemic Onset Juvenile Idiopathic Arthritis

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Sources:
41NIH Rare Diseases, 47Orphanet, 43Novoseek, 60UMLS, 26ICD10 via Orphanet
See all sources

Systemic Onset Juvenile Idiopathic Arthritis, Aliases & Descriptions:

Name: Systemic Onset Juvenile Idiopathic Arthritis 41
Systemic-Onset Juvenile Idiopathic Arthritis 41 47
Systemic Polyarthritis 41 47
Still Disease 41 47
Systemic Onset Juvenile Rheumatoid Arthritis 41
 
Systemic Onset Juvenile Chronic Arthritis 60
Systemic Juvenile Idiopathic Arthritis 41
Juvenile-Onset Still Disease 60
Still's Disease 41
Stills Disease 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

47
systemic-onset juvenile idiopathic arthritis:
Prevalence: 1-9/100000 (Europe); Age of onset: Childhood; Age of death: normal life expectancy


External Ids:

Orphanet47 85414
ICD10 via Orphanet26 M08.2

Summaries for Systemic Onset Juvenile Idiopathic Arthritis

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Wikipedia:63 Systemic onset juvenile idiopathic arthritis (also known as Systemic juvenile idiopathic arthritis... more...

MalaCards based summary: Systemic Onset Juvenile Idiopathic Arthritis, also known as systemic-onset juvenile idiopathic arthritis, is related to arthritis and juvenile rheumatoid arthritis, and has symptoms including skin rash, arthritis and joint swelling. An important gene associated with Systemic Onset Juvenile Idiopathic Arthritis is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Selenium Pathway and Hematopoietic cell lineage. The compounds tocilizumab and abatacept have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and bone marrow, and related mouse phenotypes are endocrine/exocrine gland and skeleton.

Related Diseases for Systemic Onset Juvenile Idiopathic Arthritis

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Diseases related to Systemic Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis32.0IL6, TNF
2juvenile rheumatoid arthritis31.7IL6, TNF
3atopy30.6MIF, IL10
4respiratory failure30.5IL6, TNF
5peritonitis30.1TNF, MEFV, IL6
6systemic lupus erythematosus29.8IL6, IL10, MIF, TNF
7rheumatoid arthritis29.5TNF, MEFV, MIF, IL10, IL6
8macrophage activation syndrome10.9
9kawasaki disease10.7
10cardiac tamponade10.5
11amyloidosis10.5
12blindness10.5
13endophthalmitis10.5PRF1
14palindromic rheumatism10.4MEFV
15erysipelas10.4MEFV
16polyarteritis nodosa10.4MEFV
17leishmaniasis10.4IL10
18encephalitis10.3
19crohn's disease10.3TNF
20renal cell carcinoma10.3
21celiac disease10.3
22keratitis10.3
23acute liver failure10.3
24autoimmune hepatitis10.3
25congestive heart failure10.3
26glomerulonephritis10.3
27hemophagocytic lymphohistiocytosis10.3
28hepatitis10.3
29leukemia10.3
30pure red-cell aplasia10.3
31germinoma10.3
32adult-onset still's disease10.3
33influenza10.3
34lupus erythematosus10.3
35lymphoblastic leukemia10.3
36myocarditis10.3
37myositis10.3
38pericardial effusion10.3
39nodular regenerative hyperplasia10.3
40autoimmune lymphoproliferative syndrome10.2
41gastric ulcer10.2
42cervicitis10.2
43gastroenteritis10.2
44pericarditis10.2
45castleman's disease10.2
46pediatric systemic lupus erythematosus10.2
47blau syndrome10.2MEFV, TNF
48periodic fever, familial10.2MEFV, TNF
49familial mediterranean fever, ar10.2MEFV, TNF
50plasmodium falciparum malaria10.2IL10, MIF

Graphical network of the top 20 diseases related to Systemic Onset Juvenile Idiopathic Arthritis:



Diseases related to systemic onset juvenile idiopathic arthritis

Symptoms for Systemic Onset Juvenile Idiopathic Arthritis

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Symptoms:

 47 (show all 13)
  • cutaneous rash
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • arthritis/synovitis/synovial proliferation
  • autoimmunity/autoimmune reaction/autoantibodies
  • fever/chilling
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • mediastinal/hilar adenopathies
  • acute abdominal pain/colic
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion

HPO human phenotypes related to Systemic Onset Juvenile Idiopathic Arthritis:

(show all 12)
id Description Frequency HPO Source Accession
1 skin rash hallmark (90%) HP:0000988
2 arthritis hallmark (90%) HP:0001369
3 joint swelling hallmark (90%) HP:0001386
4 arthralgia hallmark (90%) HP:0002829
5 autoimmunity hallmark (90%) HP:0002960
6 abnormality of temperature regulation hallmark (90%) HP:0004370
7 mediastinal lymphadenopathy typical (50%) HP:0100721
8 abnormality of the pericardium occasional (7.5%) HP:0001697
9 splenomegaly occasional (7.5%) HP:0001744
10 abdominal pain occasional (7.5%) HP:0002027
11 abnormality of the pleura occasional (7.5%) HP:0002103
12 hepatomegaly occasional (7.5%) HP:0002240

Drugs & Therapeutics for Systemic Onset Juvenile Idiopathic Arthritis

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Drug clinical trials:

Search ClinicalTrials for Systemic Onset Juvenile Idiopathic Arthritis

Search NIH Clinical Center for Systemic Onset Juvenile Idiopathic Arthritis

Genetic Tests for Systemic Onset Juvenile Idiopathic Arthritis

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Anatomical Context for Systemic Onset Juvenile Idiopathic Arthritis

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MalaCards organs/tissues related to Systemic Onset Juvenile Idiopathic Arthritis:

31
Bone, Liver, Bone marrow, Skin, Prostate, T cells, Heart, Myeloid, B cells

Animal Models for Systemic Onset Juvenile Idiopathic Arthritis or affiliated genes

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MGI Mouse Phenotypes related to Systemic Onset Juvenile Idiopathic Arthritis:

35 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.3IL6, IL10, PRF1, TNF
2MP:00053908.1TNF, MEFV, IL10, IL6
3MP:00020068.0IL6, IL10, MIF, PRF1, TNF
4MP:00028738.0IL10, MIF, MEFV, PRF1
5MP:00053707.8TNF, PRF1, MEFV, IL10, IL6
6MP:00107717.7TNF, PRF1, MEFV, IL10, IL6
7MP:00053787.7TNF, PRF1, MEFV, IL10, IL6
8MP:00053897.7TNF, PRF1, MEFV, IL10
9MP:00107687.6IL6, IL10, MEFV, PRF1, TNF
10MP:00053977.4TNF, PRF1, MEFV, MIF, IL10, IL6
11MP:00053877.3TNF, PRF1, MEFV, MIF, IL10, IL6
12MP:00053847.3TNF, PRF1, MEFV, MIF, IL10, IL6
13MP:00053767.3TNF, PRF1, MEFV, MIF, IL10, IL6

Publications for Systemic Onset Juvenile Idiopathic Arthritis

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Articles related to Systemic Onset Juvenile Idiopathic Arthritis:

(show top 50)    (show all 101)
idTitleAuthorsYear
1
Myositis as a presenting feature of systemic onset juvenile idiopathic arthritis. (25677488)
2015
2
Soluble CD25 in serum: a potential marker for subclinical macrophage activation syndrome in patients with active systemic onset juvenile idiopathic arthritis. (24417800)
2014
3
Pathogenesis of systemic inflammatory diseases in childhood: "Lessons from clinical trials of anti-cytokine monoclonal antibodies for Kawasaki disease, systemic onset juvenile idiopathic arthritis, and cryopyrin-associated periodic fever syndrome" (24842480)
2014
4
A130: Is the CCR5-delta32 Mutation Protective Against Systemic-Onset Juvenile Idiopathic Arthritis? (24677884)
2014
5
Atopy in children with systemic onset juvenile idiopathic arthritis (SoJIA) is associated with a worse outcome. (24611751)
2014
6
AA amyloidosis associated with systemic-onset juvenile idiopathic arthritis. (23664546)
2013
7
Anakinra pharmacokinetics in children and adolescents with systemic-onset juvenile idiopathic arthritis and autoinflammatory syndromes. (23915458)
2013
8
Congestive heart failure: an uncommon presentation of systemic onset juvenile idiopathic arthritis (SOJIA). (22161583)
2013
9
Nodular regenerative hyperplasia of the liver as a complication of long-standing systemic-onset juvenile idiopathic arthritis. (24315465)
2013
10
Macrophage activation syndrome in children with systemic onset juvenile idiopathic arthritis: clinical experience from northwest India. (21221591)
2012
11
Leflunomide in systemic onset Juvenile idiopathic arthritis. (23024081)
2012
12
Anakinra: a safe and effective first-line treatment in systemic onset juvenile idiopathic arthritis (SoJIA). (22083619)
2012
13
Development of germinoma during the treatment of systemic-onset juvenile idiopathic arthritis with infliximab. (22072226)
2012
14
A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial). (21173013)
2011
15
De novo 19q13.42 duplications involving NLRP gene cluster in a patient with systemic-onset juvenile idiopathic arthritis. (21326309)
2011
16
Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis. (21538322)
2011
17
IL10 promoter polymorphisms are associated with systemic onset juvenile idiopathic arthritis (SoJIA). (21205466)
2010
18
Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis. (20019066)
2010
19
Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis. (20472718)
2010
20
Peripheral ulcerative keratitis in a patient with systemic-onset juvenile idiopathic arthritis. (21162464)
2010
21
Incomplete Kawasaki syndrome followed by systemic onset-juvenile idiopathic arthritis mimicking Kawasaki syndrome. (19455336)
2010
22
Bicipital synovial cyst in systemic-onset juvenile idiopathic arthritis. (20338579)
2010
23
Perioperative anesthetic concerns in a child with systemic onset juvenile idiopathic arthritis syndrome. (20670244)
2010
24
Fever of unknown origin in a patient of systemic onset juvenile idiopathic arthritis. (22918076)
2010
25
Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis. (19714583)
2009
26
Macrophage activation syndrome in an inadequately treated patient with systemic onset juvenile idiopathic arthritis. (20502084)
2009
27
Rituximab therapy for refractory systemic-onset juvenile idiopathic arthritis. (19286909)
2009
28
The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleukin-1beta form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritis. (19248102)
2009
29
Nodulosis in systemic onset juvenile idiopathic arthritis: an uncommon event with spontaneous resolution. (19840317)
2009
30
Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis. (18311812)
2008
31
Macrophage activation syndrome in 13 children with systemic-onset juvenile idiopathic arthritis. (18661762)
2008
32
Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: preliminary experience in France. (17947302)
2008
33
Systemic onset juvenile idiopathic arthritis--its unusual presentation. (18536898)
2008
34
Is tocilizumab a good therapeutic option for RA and systemic-onset juvenile idiopathic arthritis? (18779846)
2008
35
Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial. (18358927)
2008
36
Large pericardial effusion requiring pericardiocentesis as cardinal sign of macrophage activation syndrome in systemic onset-juvenile idiopathic arthritis. (17160383)
2007
37
Treatment of difficult cases of systemic-onset juvenile idiopathic arthritis with tacrolimus. (17187256)
2007
38
Failure to distinguish systemic-onset juvenile idiopathic arthritis from incomplete Kawasaki disease in an infant. (17854457)
2007
39
Systemic lupus erythematosus with major organ involvement in a patient with systemic-onset juvenile idiopathic arthritis. (17407252)
2007
40
Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade. (17724127)
2007
41
Systemic onset juvenile idiopathic arthritis: update on pathogenesis and treatment. (20477675)
2007
42
Developing a disease activity tool for systemic-onset juvenile idiopathic arthritis by international consensus using the Delphi approach. (16159950)
2005
43
Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis. (15751095)
2005
44
Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade. (15851489)
2005
45
Does systemic-onset juvenile idiopathic arthritis belong under juvenile idiopathic arthritis? (15956091)
2005
46
Coronary artery dilation among patients presenting with systemic-onset juvenile idiopathic arthritis. (15930186)
2005
47
Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis. (12746913)
2003
48
Infliximab for systemic onset juvenile idiopathic arthritis: experience in 3 children. (12022340)
2002
49
Systemic onset juvenile idiopathic arthritis: a retrospective study of 80 consecutive patients followed for 10 years. (11196535)
2001
50
Macrophage activation syndrome as the initial manifestation of systemic onset juvenile idiopathic arthritis. (11791663)
2001

Variations for Systemic Onset Juvenile Idiopathic Arthritis

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Expression for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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LifeMap Discovery
Genes differentially expressed in tissues of Systemic Onset Juvenile Idiopathic Arthritis patients vs. healthy controls: 30 (show all 13)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1MMP1matrix metallopeptidase 1 (interstitial collagenase)Oral Cavity+6.950.000
2PTHLHparathyroid hormone-like hormoneOral Cavity+4.090.000
3KRT17keratin 17Oral Cavity+3.760.000
4LAMC2laminin, gamma 2Oral Cavity+3.680.000
5CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)Oral Cavity+3.440.000
6MMP3matrix metallopeptidase 3 (stromelysin 1, progelatinase)Oral Cavity+3.390.000
7WDR66WD repeat domain 66Oral Cavity+3.370.000
8PRR9proline rich 9Oral Cavity+3.340.004
9IL8interleukin 8Oral Cavity+3.330.000
10S100A7AS100 calcium binding protein A7AOral Cavity+3.150.001
11IFI6interferon, alpha-inducible protein 6Oral Cavity+3.130.000
12INHBAinhibin, beta AOral Cavity+3.130.001
13EPPK1epiplakin 1Oral Cavity+3.070.000

Search GEO for disease gene expression data for Systemic Onset Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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Pathways related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
thioredoxin pathway36
9.5IL6, TNF
29.5IL6, TNF
39.5IL6, TNF
49.5IL6, TNF
5
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.5TNF, IL6
69.5TNF, IL6
79.5IL6, TNF
89.5IL6, TNF
9
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.4PRF1, TNF
10
Show member pathways
FAS pathway and Stress induction of HSP regulation36
Apoptosis and survival FAS signaling cascades58
Caspase cascade in apoptosis36
9.4TNF, PRF1
11
Show member pathways
9.1TNF, IL10
129.1TNF, MIF, IL6
139.1TNF, MIF, IL6
149.1IL6, MIF, TNF
15
Show member pathways
Immune response MIF in innate immunity response58
9.1IL6, MIF, TNF
16
Show member pathways
8.9TNF, MEFV, IL6
17
Show member pathways
8.7TNF, IL10, IL6
18
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.7IL6, IL10, TNF
19
Show member pathways
8.7TNF, IL10, IL6
20
Show member pathways
8.7IL6, IL10, TNF
21
Show member pathways
8.7TNF, IL10, IL6
228.7IL6, IL10, TNF
23
Show member pathways
IL27-mediated signaling events36
8.7TNF, IL10, IL6
248.7TNF, IL10, IL6
258.7TNF, IL10, IL6
268.7IL6, IL10, TNF
278.7IL6, IL10, TNF
288.7TNF, IL10, IL6
298.7IL6, IL10, TNF
308.7IL6, IL10, TNF
31
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.7TNF, IL10, IL6
328.7IL6, IL10, TNF
33
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
8.7IL6, IL10, TNF
34
Show member pathways
8.3TNF, MIF, IL10, IL6
35
Show member pathways
8.2TNF, PRF1, IL10, IL6

Compounds for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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Compounds related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1tocilizumab43 1210.9TNF, IL6
2abatacept43 1210.9TNF, IL6
3tenidap43 2810.7IL6, TNF
4anakinra43 1210.7IL6, TNF
5rantes439.6IL10, MIF
6taurine chloramine439.5IL6, TNF
7vesnarinone439.4IL6, TNF
8interferon gamma439.4IL10, TNF
9herbimycin a43 5910.3TNF, MIF, IL6
10curcumin439.2IL6, MIF, TNF
11cdp571439.2TNF, IL10, IL6
12gabexate mesilate439.2IL6, IL10, TNF
13ulinastatin439.2TNF, IL10, IL6
14mip 1alpha439.2IL6, IL10, TNF
15il-12439.2IL6, IL10, TNF
16adalimumab43 49 1211.2TNF, IL10, IL6
17imiquimod43 59 28 1212.2IL6, IL10, TNF
18polymyxin b439.1TNF, IL10, IL6
19groalpha439.1TNF, IL10, IL6
20okt3439.1TNF, IL10, IL6
21gm-csf43 2810.1IL6, IL10, TNF
22lipoteichoic acid439.1TNF, IL10, IL6
238-isoprostane439.1IL6, IL10, TNF
242,5-oligoadenylate439.1TNF, IL10, IL6
25polyinosinic-polycytidylic acid439.1TNF, IL10, IL6
26etanercept43 49 1211.1IL6, IL10, TNF
27il 10439.1TNF, IL10, IL6
28infliximab43 49 1211.1IL6, IL10, TNF
29peptidoglycan43 2810.1IL6, IL10, TNF
30ivig439.1TNF, IL10, IL6
31pentoxifylline43 1210.1IL6, IL10, TNF
32ccl343 2810.1IL6, IL10, TNF
33neopterin439.1TNF, IL10, IL6
3415-deoxy-delta-12,14-prostaglandin j2439.1IL6, IL10, TNF
35rituximab43 49 1211.1IL6, IL10, TNF
36atorvastatin43 49 28 24 1213.0TNF, IL10, IL6
37prednisolone43 28 1211.0TNF, IL10, IL6
38tgf beta1439.0TNF, IL10, IL6
39simvastatin43 49 59 28 24 1214.0TNF, IL10, IL6
40blys438.8TNF, IL10
41thalidomide43 49 59 1211.7TNF, MIF, IL10, IL6
42hydrocortisone43 2 59 1211.7TNF, MIF, IL10, IL6
43sb 20358043 599.7TNF, MIF, IL10, IL6
44pge2438.6IL6, IL10, MIF, TNF
45thymidine43 249.6TNF, MIF, IL10, IL6
46cycloheximide438.5IL6, IL10, PRF1, TNF
47dexamethasone43 49 28 1211.4TNF, MIF, IL10, IL6
48vegf438.3TNF, MIF, IL10, IL6
49nitric oxide43 24 1210.3IL6, IL10, MIF, TNF
50endotoxin438.1IL6, IL10, MIF, MEFV, TNF

GO Terms for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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Cellular components related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.6IL6, MIF, PRF1, TNF
2extracellular spaceGO:00056158.0IL6, IL10, MIF, TNF

Biological processes related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell proliferation involved in salivary gland morphogenesisGO:00606649.9TNF, IL6
2negative regulation of lipid storageGO:00108889.9TNF, IL6
3positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:020003439.9MIF, TNF
4positive regulation of chemokine productionGO:00327229.9TNF, IL6
5positive regulation of nitric oxide biosynthetic processGO:00454299.8IL6, TNF
6defense response to Gram-positive bacteriumGO:00508309.8TNF, IL6
7negative regulation of fat cell differentiationGO:00455999.8IL6, TNF
8positive regulation of interleukin-6 productionGO:00327559.8TNF, IL6
9positive regulation of smooth muscle cell proliferationGO:00486619.8IL6, TNF
10response to mechanical stimulusGO:00096129.7TNF, IL6
11positive regulation of MAP kinase activityGO:00434069.7MIF, TNF
12humoral immune responseGO:00069599.7TNF, IL6
13positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.6MIF, IL6
14receptor biosynthetic processGO:00328009.5IL10, TNF
15negative regulation of cytokine secretion involved in immune responseGO:00027409.5TNF, IL10
16positive regulation of peptidyl-serine phosphorylationGO:00331389.5TNF, MIF, IL6
17negative regulation of growth of symbiont in hostGO:00441309.5TNF, IL10
18negative regulation of interleukin-6 productionGO:00327159.5IL10, TNF
19positive regulation of ERK1 and ERK2 cascadeGO:00703749.4IL6, MIF, TNF
20response to insulinGO:00328689.4IL6, IL10
21positive regulation of protein kinase B signalingGO:00518979.4IL6, TNF
22response to activityGO:00148239.4IL10, TNF
23negative regulation of interleukin-12 productionGO:00326959.4IL10, MEFV
24negative regulation of gene expressionGO:00106299.2MIF, TNF
25response to glucocorticoidGO:00513849.1IL6, IL10, TNF
26positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.1IL6, IL10, TNF
27positive regulation of cytokine secretionGO:00507159.1IL10, MIF, TNF
28response to drugGO:00424939.0TNF, IL10, IL6
29negative regulation of apoptotic processGO:00430668.9IL6, IL10, MIF
30positive regulation of transcription, DNA-templatedGO:00458938.8IL6, IL10, TNF
31positive regulation of transcription from RNA polymerase II promoterGO:00459448.7IL6, IL10, TNF
32inflammatory responseGO:00069548.0IL6, IL10, MIF, MEFV, TNF

Molecular functions related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.3IL6, IL10, MIF, TNF

Products for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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Sources for Systemic Onset Juvenile Idiopathic Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet