MCID: SYS034
MIFTS: 47

Systemic Onset Juvenile Idiopathic Arthritis malady

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Summaries for Systemic Onset Juvenile Idiopathic Arthritis

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33MalaCards
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MalaCards: Systemic Onset Juvenile Idiopathic Arthritis, also known as systemic onset juvenile rheumatoid arthritis, is related to arthritis and kawasaki disease. An important gene associated with Systemic Onset Juvenile Idiopathic Arthritis is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are Monoamine Transport and Cytosolic DNA-sensing pathway. The compounds tenidap and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and myeloid, and related mouse phenotypes are skeleton and integument.

Aliases & Classifications for Systemic Onset Juvenile Idiopathic Arthritis

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone


Aliases & Descriptions:

systemic onset juvenile idiopathic arthritis 43
systemic onset juvenile rheumatoid arthritis 43
systemic onset juvenile chronic arthritis 61
systemic juvenile idiopathic arthritis 43
juvenile-onset still disease 61
still's disease 43
stills disease 45


Related Diseases for Systemic Onset Juvenile Idiopathic Arthritis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Systemic Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 238)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.9IL6, IL1B, TNF
2kawasaki disease30.9CRP, S100A12
3amyloidosis30.6IL1RAPL2, MEFV, CRP
4juvenile rheumatoid arthritis30.6IL6, IL1RAPL2, IL1R1, IL1RN, CRP, TNF
5hemophagocytic lymphohistiocytosis30.4RAB27A, PRF1, UNC13D
6urticaria30.4IL1RAPL2, GZMB
7celiac disease30.4IL18RAP, GZMB
8hepatitis c30.4IL1RAPL2, IL1R1, IL18, TLR4
9adult-onset still's disease30.4IL6, IL1RAPL2, IL1R1, IL18, CRP
10systemic lupus erythematosus30.4IL6, IL1RAPL2, IL1R1, IL1RN, IL18, MIF
11sepsis30.4IL6, IL1B, IL1RAPL2, IL1R1, IL1RN, IL18
12gastric ulcer30.3S100A8
13osteoporosis29.8SLC26A2, IL6, IL1RAPL2, IL1RN
14cardiac tamponade10.4
15acute liver failure10.3
16hepatitis e10.3
17autoimmune hepatitis10.3
18hepatitis d10.3
19n syndrome10.3
20acute leukemia10.3
21hepatitis a10.3
22young syndrome10.3
23germinoma10.3
24nodular regenerative hyperplasia10.3
25oligoarticular juvenile arthritis10.3
26autoimmune lymphoproliferative syndrome10.2
27adult syndrome10.2
28castleman's disease10.2
29multicentric castleman’s disease10.2
30multicentric castleman disease10.2
31brucellosis10.0MEFV
32lichen planus10.0GZMB
33liver cirrhosis10.0GZMB
34peptic ulcer10.0S100A8
35influenza10.0GZMB
36pericarditis10.0MEFV
37esophagitis10.0S100A8
38bronchopulmonary dysplasia10.0IL1RN
39lupus erythematosus10.0IL18
40histiocytosis10.0S100A9
41colon cancer10.0MIF
42dengue shock syndrome10.0IL1RN
43myelodysplastic syndromes10.0GZMB
44pyoderma gangrenosum10.0MEFV
45cervical cancer10.0IL1R1
46myocarditis10.0PRF1
47duodenitis10.0S100A8
48palindromic rheumatism10.0MEFV
49bronchiolitis10.0TLR4
50human immunodeficiency virus infectious disease10.0PRF1

Graphical network of the top 20 diseases related to Systemic Onset Juvenile Idiopathic Arthritis:



Diseases related to systemic onset juvenile idiopathic arthritis

Clinical Features for Systemic Onset Juvenile Idiopathic Arthritis

Drugs & Therapeutics for Systemic Onset Juvenile Idiopathic Arthritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Systemic Onset Juvenile Idiopathic Arthritis

Search NIH Clinical Center for Systemic Onset Juvenile Idiopathic Arthritis

Search CenterWatch for Systemic Onset Juvenile Idiopathic Arthritis

Genetic Tests for Systemic Onset Juvenile Idiopathic Arthritis

Anatomical Context for Systemic Onset Juvenile Idiopathic Arthritis

Sources:
33MalaCards
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MalaCards organs/tissues related to Systemic Onset Juvenile Idiopathic Arthritis:

33
Heart, Liver, Myeloid, B lymphoblasts, B cells

Animal Models for Systemic Onset Juvenile Idiopathic Arthritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Systemic Onset Juvenile Idiopathic Arthritis

Sources:
51PubMed
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Articles related to Systemic Onset Juvenile Idiopathic Arthritis:

(show top 50)    (show all 95)
idTitleAuthorsYear
1
Soluble CD25 in serum: a potential marker for subclinical macrophage activation syndrome in patients with active systemic onset juvenile idiopathic arthritis. (24417800)
2014
2
Congestive heart failure: an uncommon presentation of systemic onset juvenile idiopathic arthritis (SOJIA). (22161583)
2013
3
Thalidomide for systemic onset juvenile idiopathic arthritis. (23474929)
2013
4
Systemic-onset juvenile idiopathic arthritis and HLA-B27 juvenile-onset undifferentiated spondyloarthritis in the same patient. (23295075)
2013
5
Incomplete Kawasaki disease followed by systemic onset juvenile idiopathic arthritis- the diagnostic dilemma. (23054859)
2013
6
Systemic onset juvenile idiopathic arthritis with macrophage activation syndrome misdiagnosed as Kawasaki disease: case report and literature review. (21132551)
2013
7
Leflunomide in systemic onset Juvenile idiopathic arthritis. (23024081)
2012
8
Anakinra: a safe and effective first-line treatment in systemic onset juvenile idiopathic arthritis (SoJIA). (22083619)
2012
9
Development of germinoma during the treatment of systemic-onset juvenile idiopathic arthritis with infliximab. (22072226)
2012
10
The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis. (22267331)
2012
11
Recurrent cardiac tamponade in a child with newly diagnosed systemic-onset juvenile idiopathic arthritis. (22955481)
2012
12
Safety and response to influenza vaccine in patients with systemic-onset juvenile idiopathic arthritis receiving tocilizumab. (22322589)
2012
13
Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist. (22490470)
2012
14
ANCA-associated glomerulonephritis in systemic-onset juvenile idiopathic arthritis. (22189036)
2012
15
Initial manifestations and clinical course of systemic onset juvenile idiopathic arthritis: a ten-year retrospective study. (23089689)
2012
16
De novo 19q13.42 duplications involving NLRP gene cluster in a patient with systemic-onset juvenile idiopathic arthritis. (21326309)
2011
17
Association of systemic-onset juvenile idiopathic arthritis and celiac disease - a case report. (22472933)
2011
18
Hypocomplementemia associated with macrophage activation syndrome in systemic juvenile idiopathic arthritis and adult onset still's disease: 3 cases. (21285182)
2011
19
Case of systemic-onset juvenile idiopathic arthritis complicated with sepsis --usefulness of cytokine profile for the differentiation between macrophage activation syndrome and sepsis]. (21628853)
2011
20
Cardiac tamponade in a child with systemic-onset juvenile idiopathic arthritis: dramatic improvement after interleukin-1 blockade by anakinra. (21544583)
2011
21
Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis. (20019066)
2010
22
Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis. (20472718)
2010
23
Peripheral ulcerative keratitis in a patient with systemic-onset juvenile idiopathic arthritis. (21162464)
2010
24
Incomplete Kawasaki syndrome followed by systemic onset-juvenile idiopathic arthritis mimicking Kawasaki syndrome. (19455336)
2010
25
Bicipital synovial cyst in systemic-onset juvenile idiopathic arthritis. (20338579)
2010
26
Fever of unknown origin in a patient of systemic onset juvenile idiopathic arthritis. (22918076)
2010
27
Macrophage activation syndrome in an inadequately treated patient with systemic onset juvenile idiopathic arthritis. (20502084)
2009
28
Rituximab therapy for refractory systemic-onset juvenile idiopathic arthritis. (19286909)
2009
29
The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleukin-1beta form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritis. (19248102)
2009
30
Nodulosis in systemic onset juvenile idiopathic arthritis: an uncommon event with spontaneous resolution. (19840317)
2009
31
MEFV mutations in systemic onset juvenile idiopathic arthritis. (18984609)
2009
32
Rituximab therapy produced rapid and sustained clinical improvement in a patient with systemic onset juvenile idiopathic arthritis refractory to TNF alpha antagonists. (20009975)
2009
33
Macrophage activation syndrome in 13 children with systemic-onset juvenile idiopathic arthritis. (18661762)
2008
34
Systemic onset juvenile idiopathic arthritis--its unusual presentation. (18536898)
2008
35
Development of autoimmune hepatitis in a child with systemic-onset juvenile idiopathic arthritis during therapy with etanercept. (18824922)
2008
36
The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis. (18438814)
2008
37
Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade. (17724127)
2007
38
Systemic onset juvenile idiopathic arthritis: update on pathogenesis and treatment. (20477675)
2007
39
Positive association of SLC26A2 gene polymorphisms with susceptibility to systemic-onset juvenile idiopathic arthritis. (17393463)
2007
40
A multicenter study of patients with adult-onset Still's disease compared with systemic juvenile idiopathic arthritis. (16365690)
2006
41
Developing a disease activity tool for systemic-onset juvenile idiopathic arthritis by international consensus using the Delphi approach. (16159950)
2005
42
Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis. (15751095)
2005
43
Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade. (15851489)
2005
44
Coronary artery dilation among patients presenting with systemic-onset juvenile idiopathic arthritis. (15930186)
2005
45
Nasal septal perforation: a novel clinical manifestation of systemic juvenile idiopathic arthritis/adult onset Still's disease. (16331776)
2005
46
Serum protein profile in systemic-onset juvenile idiopathic arthritis differentiates response versus nonresponse to therapy. (15987476)
2005
47
Early activation of cutaneous vessels and epithelial cells is characteristic of acute systemic onset juvenile idiopathic arthritis. (15810883)
2005
48
Delayed maculopapular, urticarial rash due to infliximab in two children with systemic onset juvenile idiopathic arthritis. (15103034)
2004
49
Infliximab for systemic onset juvenile idiopathic arthritis: experience in 3 children. (12022340)
2002
50
Systemic onset juvenile idiopathic arthritis: a retrospective study of 80 consecutive patients followed for 10 years. (11196535)
2001

Genetic Variations for Systemic Onset Juvenile Idiopathic Arthritis

Expression for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Systemic Onset Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

Sources:
38NCBI BioSystems Database, 30KEGG, 54Reactome, 52QIAGEN, 12EMD Millipore, 60Tocris Bioscience, 53R&D Systems
See all sources

Pathways related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IL1R1
210.2IL18
3
wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF)
10.1RAB27A, UNC13D
410.0TLR4, IL18
510.0IL18, TLR4
69.9IL18, IL1B
79.9TLR4, IL1B
8
Hide members
9.8TLR4, IL18RAP
99.8TNF, GZMB, PRF1
10
Apoptosis and survival Caspase cascade
Hide members
9.8TNF, PRF1, GZMB
11
Hide members
9.7IL1RN, IL1R1, IL1B
129.7PRF1, IL18RAP, IL18
139.7IL6, MIF, TNF
14
Hide members
9.6IL1B, TLR4, IL1R1
159.6TLR4, TNF, IL1R1
169.6TLR4, TNF, IL18
17
Hide members
9.6IL18RAP, IL18, TLR4
189.6IL1B, IL18, TNF
199.5IL1B, TNF, IL6
20
Hide members
9.5GZMB, PRF1, IL1R1, TNF
219.4IL1B, IL18, TLR4, IL6
22
Hide members
9.3TNF, IL1R1, TLR4, IL1B
23
Hide members
9.3TNF, TLR4, IL1R1, IL1B
249.3IL1B, TLR4, TNF, IL1R1
259.3IL1RN, TNF, IL1B, IL6
269.3IL1B, TNF, IL18, TLR4
279.3TNF, IL1R1, IL1B, IL6
289.3TNF, IL18, IL1B, IL6
299.3IL6, TNF, IL18, IL1B
30
Hide members
9.3IL6, IL1B, TNF, TLR4
319.3TLR4, TNF, IL1B, IL6
329.3TLR4, TNF, IL1B, IL6
339.2TNF, CRP, IL1B, IL6
34
Hide members
9.2IL6, IL1B, IL1R1, TLR4, GZMB
35
Hide members
9.1IL1RN, IL1R1, IL18, IL6, IL1B
36
Hide members
9.1IL1RN, IL6, IL1B, IL1R1, IL18
37
Hide members
9.1IL18, IL1R1, IL1B, GZMB, IL18RAP
38
Hide members
9.1IL1B, IL18, MEFV, TNF, IL6
39
Hide members
9.0IL6, TNF, TLR4, IL1R1, IL1B
409.0IL6, TLR4, IL1R1, TNF, IL1B
419.0IL1B, IL6, TLR4, TNF, IL1R1
42
Hide members
9.0TNF, TLR4, IL6, IL1B, IL18
43
Development PDGF signaling via STATs and NF-kB
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8.9IL6, IL1B, IL18RAP, TNF, IL18
44
Hide members
8.9IL6, IL1B, IL18, PRF1, GZMB, TNF
45
Hide members
8.8MIF, IL6, IL1R1, TNF, IL1B, TLR4
46
Immune response Bacterial infections in normal airways
Hide members
8.8TLR4, IL1RN, IL1R1, IL1B, IL6, TNF
47
Hide members
8.8IL1R1, IL1B, IL6, TNF, IL18, TLR4
48
Hide members
8.8TNF, IL1R1, TLR4, IL6, IL1B, IL18
49
Hide members
8.6IL6, TLR4, TNF, IL18RAP, IL1B, IL18
50
Hide members
8.3IL1B, IL6, TLR4, S100A12, MEFV, IL18

Compounds for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience
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Compounds related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1tenidap45 2911.6IL1R1
2cycloheximide4510.0IL18, IL1RAPL2
3rosiglitazone45 50 29 11 2413.8IL1RN, IL18, IL1R1, IL6
4endotoxin459.7S100A9, S100A8, MEFV
5pentoxifylline45 1110.5IL18, IL1RAPL2, IL1RN, IL1R1
6prednisolone45 29 1111.5GZMB, CRP, IL1R1, IL1RAPL2
7pirfenidone45 6010.5IL1B, S100A9, S100A8
8cyclosporin a45 29 6011.4GZMB, IL1RAPL2, IL1R1
9il-12459.3IL1R1, IL1B, IL6, TNF, IL18
10polysulfone459.3IL1B, IL1RAPL2, IL1RN, IL1R1
11polymyxin b459.3TLR4, IL1RN, IL1B, TNF, IL6
12peptidoglycan45 2910.1IL6, IL1B, IL1R1, IL1RN, TNF, TLR4
13git 27609.1MIF, S100A9, S100A8, IL1R1, IL1B
144-ipp609.1S100A9, S100A8, MIF, IL1B, IL1R1
15ccl345 2910.1IL6, IL1R1, IL1B, TNF, TLR4, IL18
16polyinosinic-polycytidylic acid459.1IL6, IL1B, TNF, IL18, TLR4
17as 10160 4510.1S100A9, IL1B, IL1R1, MIF, S100A8
18glucose459.0GZMB, S100A12, RAB27A, IL1RAPL2
19imiquimod45 29 60 1112.0IL6, IL1RAPL2, IL18, TNF, TLR4
20lipoteichoic acid459.0TLR4, IL1RN, IL1R1, IL1B, IL6, IL18
21adalimumab45 50 1110.9IL6, IL1RAPL2, IL1R1, IL1RN, CRP, TNF
22leflunomide50 45 1110.8IL1B, IL1RAPL2, IL1R1, TNF, IL1RN, IL6
23sulfasalazine45 29 50 1111.8IL1RAPL2, IL1R1, IL1B, CRP, IL1RN, TNF
24monosodium urate458.7IL1B, S100A9, S100A8, IL1R1, IL1RAPL2
25poly(i-c)458.7IL1B, TLR4, TNF, IL18, IL6
26atorvastatin45 50 29 11 2412.7TLR4, CRP, IL18, IL1RN, TNF, IL6
27leukotriene b445 60 2410.6IL1B, IL6, IL1R1, TNF, IL1RAPL2, IL1RN
28dexamethasone45 50 29 1111.6SLC26A2, IL6, IL1RAPL2, IL1R1, S100A8, GZMB
29simvastatin45 50 60 29 11 2413.5IL6, IL1RN, CRP, TNF, TLR4, IL18
30tgf beta1458.5IL1RAPL2, IL1RN, IL18, TNF, IL6, IL1B
31sb 20358045 609.4IL1R1, IL1RN, IL1B, MIF, CRP, IL6
32aspirin45 50 29 2411.4IL1B, TLR4, IL1RAPL2, IL18, IL1RN, IL1R1
33il 10458.4IL6, IL1B, IL1RAPL2, IL1R1, IL1RN, IL18
34etanercept45 50 1110.3IL1R1, IL1RAPL2, IL1B, IL6, IL1RN, IL18
35anakinra45 119.3TNF, IL1B, CRP, IL18, IL1RN, IL1R1
36thalidomide45 50 60 1111.3IL18, IL1R1, IL1B, IL6, S100A8, MIF
37neopterin458.1IL1B, IL1RAPL2, IL1R1, IL1RN, IL18, CRP
38rantes458.1IL6, IL1B, IL1RAPL2, IL1R1, TLR4, GZMB
39infliximab45 50 1110.1IL1RAPL2, IL1B, IL6, IL1RN, IL18, CRP
40ivig458.0GZMB, S100A12, IL6, IL1B, TNF, CRP
41lactate457.9MIF, TNF, IL1R1, IL1RN, IL18, CRP
42histamine45 29 249.9IL1B, S100A8, TNF, IL6, IL1RAPL2, IL1RN
43fibrinogen457.9CRP, TLR4, S100A9, IL1R1, IL1RAPL2, IL6
44arachidonic acid45 29 11 2410.7IL1RAPL2, S100A9, TLR4, TNF, MIF, IL1B
45vegf457.6TNF, CRP, GZMB, MIF, TLR4, IL18
46cholesterol45 29 11 2410.5S100A8, IL6, IL1RAPL2, IL1R1, TLR4, S100A9
47methotrexate45 50 119.3S100A9, S100A8, TNF, CRP, IL18, IL1RN
48lipid457.3TLR4, IL1R1, IL1RN, IL18, MIF, CRP
49nitric oxide45 11 248.9TNF, S100A8, MIF, IL18, IL1RN, IL1R1
50retinoic acid45 247.9TLR4, GZMB, IL1B, IL6, IL1RAPL2, IL1R1

GO Terms for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1exocytic vesicleGO:0703829.8RAB27A, UNC13D
2extracellular spaceGO:0056157.5S100A9, S100A8, TNF, CRP, MIF, IL18
3plasma membraneGO:0058867.3IL1RN, SLC26A2, TLR4, S100A12, S100A9, S100A8
4extracellular regionGO:0055767.0IL6, S100A12, S100A9, S100A8, TNF, CRP

Biological processes related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idNameGO IDScoreTop Affiliating Genes
1natural killer cell degranulationGO:04332010.4UNC13D, RAB27A
2chronic inflammatory response to antigenic stimulusGO:00243910.3TNF, IL1RN
3positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:200034310.3TNF, MIF
4positive regulation of calcidiol 1-monooxygenase activityGO:06055910.2TNF, IL1B
5sequestering of triglycerideGO:03073010.2TNF, IL1B
6positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.2IL18, IL1B
7positive regulation of heterotypic cell-cell adhesionGO:03411610.2TNF, IL1B
8positive regulation of fever generationGO:03162210.1TNF, IL1B
9epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.1TNF, IL6
10positive regulation of interleukin-8 biosynthetic processGO:04541610.1TLR4, TNF
11positive regulation of interleukin-8 productionGO:03275710.1IL1B, IL18, TLR4
12acute-phase responseGO:00695310.0CRP, IL1RN, IL6
13positive regulation of chemokine biosynthetic processGO:04508010.0TNF, IL1B
14negative regulation of lipid storageGO:01088810.0TNF, CRP, IL6
15positive regulation of peptidyl-serine phosphorylationGO:03313810.0IL6, MIF, TNF
16T-helper 1 type immune responseGO:04208810.0IL18, TLR4
17cellular response to organic cyclic compoundGO:0714079.9IL1B, IL18, TNF
18defense response to Gram-positive bacteriumGO:0508309.9TNF, CRP, IL6
19cellular response to mechanical stimulusGO:0712609.9IL1B, IL18, TLR4
20neutrophil aggregationGO:0704889.9S100A9, S100A8
21chemokine productionGO:0326029.9S100A9, S100A8
22positive regulation of JNK cascadeGO:0463309.9IL1B, TNF, TLR4
23positive regulation of MAP kinase activityGO:0434069.9S100A12, TNF, MIF
24response to glucocorticoid stimulusGO:0513849.8IL6, IL1RN, TNF
25sequestering of zinc ionGO:0321199.8S100A9, S100A8
26MAPK cascadeGO:0001659.8IL1B, IL18, TNF
27positive regulation of ERK1 and ERK2 cascadeGO:0703749.8TLR4, TNF, MIF, IL6
28positive regulation of chemokine productionGO:0327229.8IL6, IL18, TNF, TLR4
29leukocyte migration involved in inflammatory responseGO:0025239.8S100A9, S100A8
30positive regulation of NF-kappaB import into nucleusGO:0423469.7TLR4, TNF, IL18, IL1B
31lipopolysaccharide-mediated signaling pathwayGO:0316639.7TLR4, TNF, IL18, IL1B
32positive regulation of interferon-gamma productionGO:0327299.7TLR4, TNF, IL18, IL1B
33regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.7IL1B, TNF
34positive regulation of nitric oxide biosynthetic processGO:0454299.7IL6, IL1B, TNF, TLR4
35positive regulation of interleukin-6 productionGO:0327559.7TLR4, TNF, IL1B, IL6
36chronic inflammatory responseGO:0025449.6S100A8, S100A9
37positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.6TNF, IL1B, IL6
38defense response to fungusGO:0508329.5S100A12, S100A9, S100A8
39positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431239.5TLR4, S100A12, TNF, IL1B
40response to lipopolysaccharideGO:0324969.3TLR4, S100A9, S100A8, IL6
41response to ethanolGO:0454719.3CRP, S100A8, S100A9
42activation of MAPK activityGO:0001879.2IL1B, TNF, TLR4
43defense response to bacteriumGO:0427429.2TLR4, S100A12, S100A9, S100A8
44immune responseGO:0069559.2IL1B, IL1R1, IL1RN, IL18, IL18RAP, TLR4
45neutrophil chemotaxisGO:0305939.2S100A12, S100A9, S100A8, IL1B
46activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.2S100A9, S100A8, TNF
47positive regulation of inflammatory responseGO:0507299.0TLR4, S100A12, S100A9, S100A8, IL18
48innate immune responseGO:0450878.8TLR4, S100A12, S100A9, S100A8, MEFV, MIF
49positive regulation of NF-kappaB transcription factor activityGO:0510928.3TLR4, S100A12, S100A9, S100A8, TNF, IL1B
50inflammatory responseGO:0069547.3IL6, S100A12, S100A9, S100A8, TNF, CRP

Molecular functions related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor activityGO:0049089.6IL1RAPL2, IL1R1
2Toll-like receptor 4 bindingGO:0356629.4S100A8, S100A9
3arachidonic acid bindingGO:0505449.2S100A8, S100A9
4RAGE receptor bindingGO:0507869.2S100A8, S100A9, S100A12
5cytokine activityGO:0051259.1TNF, MIF, IL18, IL1B, IL6

Products for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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Sources for Systemic Onset Juvenile Idiopathic Arthritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet