MCID: SYS034
MIFTS: 44

Systemic Onset Juvenile Idiopathic Arthritis malady

Rare diseases, Bone diseases categories

Summaries for Systemic Onset Juvenile Idiopathic Arthritis

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MalaCards based summary: Systemic Onset Juvenile Idiopathic Arthritis, also known as systemic onset juvenile rheumatoid arthritis, is related to arthritis and peritonitis. An important gene associated with Systemic Onset Juvenile Idiopathic Arthritis is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are Apoptosis and Immune response Role of DAP12 receptors in NK cells. The compounds cdp571 and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and myeloid, and related mouse phenotypes are tumorigenesis and skeleton.

Aliases & Classifications for Systemic Onset Juvenile Idiopathic Arthritis

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Sources:
42NIH Rare Diseases, 44Novoseek, 61UMLS
See all sources

Systemic Onset Juvenile Idiopathic Arthritis, Aliases & Descriptions:

Name: Systemic Onset Juvenile Idiopathic Arthritis 42
Systemic Onset Juvenile Rheumatoid Arthritis 42 61
Systemic Onset Juvenile Chronic Arthritis 61
Systemic Juvenile Idiopathic Arthritis 42
 
Juvenile-Onset Still Disease 61
Still's Disease 42
Stills Disease 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases


Related Diseases for Systemic Onset Juvenile Idiopathic Arthritis

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Graphical network of the top 20 diseases related to Systemic Onset Juvenile Idiopathic Arthritis:



Diseases related to systemic onset juvenile idiopathic arthritis

Symptoms for Systemic Onset Juvenile Idiopathic Arthritis

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Drugs & Therapeutics for Systemic Onset Juvenile Idiopathic Arthritis

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Drug clinical trials:

Search ClinicalTrials for Systemic Onset Juvenile Idiopathic Arthritis

Search NIH Clinical Center for Systemic Onset Juvenile Idiopathic Arthritis

Genetic Tests for Systemic Onset Juvenile Idiopathic Arthritis

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Anatomical Context for Systemic Onset Juvenile Idiopathic Arthritis

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MalaCards organs/tissues related to Systemic Onset Juvenile Idiopathic Arthritis:

32
Liver, Heart, Myeloid, B cells

Animal Models for Systemic Onset Juvenile Idiopathic Arthritis or affiliated genes

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MGI Mouse Phenotypes related to Systemic Onset Juvenile Idiopathic Arthritis:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7IL10, PRF1, TNF
2MP:00053908.5IL10, MEFV, TNF
3MP:00053798.3TNF, PRF1, IL10
4MP:00053708.2IL10, MEFV, PRF1, TNF
5MP:00107718.2TNF, PRF1, MEFV, IL10
6MP:00053898.2TNF, PRF1, MEFV, IL10
7MP:00053978.2IL10, MEFV, PRF1, TNF
8MP:00053878.2TNF, PRF1, MEFV, IL10
9MP:00053848.1TNF, PRF1, MEFV, IL10
10MP:00053788.1TNF, PRF1, MEFV, IL10
11MP:00053768.0TNF, PRF1, MEFV, IL10
12MP:00107687.9IL10, MEFV, PRF1, TNF

Publications for Systemic Onset Juvenile Idiopathic Arthritis

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Articles related to Systemic Onset Juvenile Idiopathic Arthritis:

(show top 50)    (show all 94)
idTitleAuthorsYear
1
Soluble CD25 in serum: a potential marker for subclinical macrophage activation syndrome in patients with active systemic onset juvenile idiopathic arthritis. (24417800)
2014
2
Pathogenesis of systemic inflammatory diseases in childhood: "Lessons from clinical trials of anti-cytokine monoclonal antibodies for Kawasaki disease, systemic onset juvenile idiopathic arthritis, and cryopyrin-associated periodic fever syndrome" (24842480)
2014
3
A130: Is the CCR5-delta32 Mutation Protective Against Systemic-Onset Juvenile Idiopathic Arthritis? (24677884)
2014
4
Atopy in children with systemic onset juvenile idiopathic arthritis (SoJIA) is associated with a worse outcome. (24611751)
2014
5
AA amyloidosis associated with systemic-onset juvenile idiopathic arthritis. (23664546)
2013
6
Anakinra pharmacokinetics in children and adolescents with systemic-onset juvenile idiopathic arthritis and autoinflammatory syndromes. (23915458)
2013
7
Congestive heart failure: an uncommon presentation of systemic onset juvenile idiopathic arthritis (SOJIA). (22161583)
2013
8
Nodular regenerative hyperplasia of the liver as a complication of long-standing systemic-onset juvenile idiopathic arthritis. (24315465)
2013
9
Macrophage activation syndrome in children with systemic onset juvenile idiopathic arthritis: clinical experience from northwest India. (21221591)
2012
10
Leflunomide in systemic onset Juvenile idiopathic arthritis. (23024081)
2012
11
Anakinra: a safe and effective first-line treatment in systemic onset juvenile idiopathic arthritis (SoJIA). (22083619)
2012
12
Development of germinoma during the treatment of systemic-onset juvenile idiopathic arthritis with infliximab. (22072226)
2012
13
Pure red cell aplasia in systemic onset juvenile idiopathic arthritis. (23448798)
2012
14
Systemic-onset juvenile idiopathic arthritis: the changing life of a rare disease. (22573189)
2012
15
A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial). (21173013)
2011
16
De novo 19q13.42 duplications involving NLRP gene cluster in a patient with systemic-onset juvenile idiopathic arthritis. (21326309)
2011
17
Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis. (21538322)
2011
18
IL10 promoter polymorphisms are associated with systemic onset juvenile idiopathic arthritis (SoJIA). (21205466)
2010
19
Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis. (20019066)
2010
20
Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis. (20472718)
2010
21
Peripheral ulcerative keratitis in a patient with systemic-onset juvenile idiopathic arthritis. (21162464)
2010
22
Incomplete Kawasaki syndrome followed by systemic onset-juvenile idiopathic arthritis mimicking Kawasaki syndrome. (19455336)
2010
23
Bicipital synovial cyst in systemic-onset juvenile idiopathic arthritis. (20338579)
2010
24
Perioperative anesthetic concerns in a child with systemic onset juvenile idiopathic arthritis syndrome. (20670244)
2010
25
Fever of unknown origin in a patient of systemic onset juvenile idiopathic arthritis. (22918076)
2010
26
Macrophage activation syndrome in an inadequately treated patient with systemic onset juvenile idiopathic arthritis. (20502084)
2009
27
Rituximab therapy for refractory systemic-onset juvenile idiopathic arthritis. (19286909)
2009
28
The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleukin-1beta form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritis. (19248102)
2009
29
Nodulosis in systemic onset juvenile idiopathic arthritis: an uncommon event with spontaneous resolution. (19840317)
2009
30
Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis. (18311812)
2008
31
Macrophage activation syndrome in 13 children with systemic-onset juvenile idiopathic arthritis. (18661762)
2008
32
Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: preliminary experience in France. (17947302)
2008
33
Systemic onset juvenile idiopathic arthritis--its unusual presentation. (18536898)
2008
34
Is tocilizumab a good therapeutic option for RA and systemic-onset juvenile idiopathic arthritis? (18779846)
2008
35
Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial. (18358927)
2008
36
Large pericardial effusion requiring pericardiocentesis as cardinal sign of macrophage activation syndrome in systemic onset-juvenile idiopathic arthritis. (17160383)
2007
37
Treatment of difficult cases of systemic-onset juvenile idiopathic arthritis with tacrolimus. (17187256)
2007
38
Failure to distinguish systemic-onset juvenile idiopathic arthritis from incomplete Kawasaki disease in an infant. (17854457)
2007
39
Systemic lupus erythematosus with major organ involvement in a patient with systemic-onset juvenile idiopathic arthritis. (17407252)
2007
40
Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade. (17724127)
2007
41
Systemic onset juvenile idiopathic arthritis: update on pathogenesis and treatment. (20477675)
2007
42
Developing a disease activity tool for systemic-onset juvenile idiopathic arthritis by international consensus using the Delphi approach. (16159950)
2005
43
Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis. (15751095)
2005
44
Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade. (15851489)
2005
45
Does systemic-onset juvenile idiopathic arthritis belong under juvenile idiopathic arthritis? (15956091)
2005
46
Coronary artery dilation among patients presenting with systemic-onset juvenile idiopathic arthritis. (15930186)
2005
47
Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis. (12746913)
2003
48
Infliximab for systemic onset juvenile idiopathic arthritis: experience in 3 children. (12022340)
2002
49
Systemic onset juvenile idiopathic arthritis: a retrospective study of 80 consecutive patients followed for 10 years. (11196535)
2001
50
Macrophage activation syndrome as the initial manifestation of systemic onset juvenile idiopathic arthritis. (11791663)
2001

Variations for Systemic Onset Juvenile Idiopathic Arthritis

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Expression for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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LifeMap Discovery
Genes differentially expressed in tissues of Systemic Onset Juvenile Idiopathic Arthritis patients vs. healthy controls: 31 (show all 216)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1PRTN3proteinase 3Blood+3.610.000
2AZU1azurocidin 1Blood+3.540.000
3MPOmyeloperoxidaseBlood+3.340.000
4ELANEelastase, neutrophil expressedBlood+3.310.000
5DEFA4defensin, alpha 4, corticostatinBlood+3.240.000
6GPER1G protein-coupled estrogen receptor 1Blood+3.070.000
7HPhaptoglobinBlood+2.990.000
8SLCO4A1solute carrier organic anion transporter family, member 4A1Blood+2.980.000
9C1QBcomplement component 1, q subcomponent, B chainBlood+2.960.000
10SLC1A3solute carrier family 1 (glial high affinity glutamate transporter), member 3Blood+2.890.000
11CENPMcentromere protein MBlood+2.890.000
12AMPHamphiphysinBlood+2.840.000
13CDT1chromatin licensing and DNA replication factor 1Blood+2.820.000
14MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)Blood+2.800.000
15KIF20Akinesin family member 20ABlood+2.790.000
16C1QAcomplement component 1, q subcomponent, A chainBlood+2.750.000
17TRIP13thyroid hormone receptor interactor 13Blood+2.740.000
18LRRN1leucine rich repeat neuronal 1Blood+2.730.000
19BPIbactericidal/permeability-increasing proteinBlood+2.700.000
20CTSGcathepsin GBlood+2.690.000
21DAAM2dishevelled associated activator of morphogenesis 2Blood+2.650.000
22CDC25Acell division cycle 25ABlood+2.650.000
23ATP6V0E2-AS1ATP6V0E2 antisense RNA 1Blood+2.650.000
24HTRA1HtrA serine peptidase 1Blood+2.640.000
25RAP1GAPRAP1 GTPase activating proteinBlood+2.630.000
26NT5DC25'-nucleotidase domain containing 2Blood+2.630.000
27APOBEC3Bapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3BBlood+2.600.000
28ZDHHC19zinc finger, DHHC-type containing 19Blood+2.560.000
29BUB1BBUB1 mitotic checkpoint serine/threonine kinase BBlood+2.540.000
30GAS2L1growth arrest-specific 2 like 1Blood+2.510.000
31C18orf56chromosome 18 open reading frame 56Blood+2.500.000
32CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)Blood+2.470.000
33TK1thymidine kinase 1, solubleBlood+2.470.000
34C1QCcomplement component 1, q subcomponent, C chainBlood+2.460.000
35GPR84G protein-coupled receptor 84Blood+2.460.000
36CEACAM8carcinoembryonic antigen-related cell adhesion molecule 8Blood+2.450.000
37UHRF1ubiquitin-like with PHD and ring finger domains 1Blood+2.450.000
38TYMSthymidylate synthetaseBlood+2.450.000
39OLAHoleoyl-ACP hydrolaseBlood+2.430.000
40ECHDC3enoyl CoA hydratase domain containing 3Blood+2.420.000
41AURKBaurora kinase BBlood+2.420.000
42FKBP5FK506 binding protein 5Blood+2.420.000
43CLEC11AC-type lectin domain family 11, member ABlood+2.410.000
44TCN2transcobalamin IIBlood+2.400.000
45SOCS1suppressor of cytokine signaling 1Blood+2.380.000
46GRB10growth factor receptor-bound protein 10Blood+2.380.000
47CEP55centrosomal protein 55kDaBlood+2.370.000
48FCARFc fragment of IgA, receptor forBlood+2.370.000
49ANKRD9ankyrin repeat domain 9Blood+2.360.000
50RETNresistinBlood+2.350.000
51CYB5R2cytochrome b5 reductase 2Blood+2.350.000
52KIF2Ckinesin family member 2CBlood+2.350.000
53ST14suppression of tumorigenicity 14 (colon carcinoma)Blood+2.340.000
54C19orf59chromosome 19 open reading frame 59Blood+2.330.000
55MCM10minichromosome maintenance complex component 10Blood+2.330.000
56ANKRD22ankyrin repeat domain 22Blood+2.320.000
57RXRGretinoid X receptor, gammaBlood+2.310.000
58LGALS3BPlectin, galactoside-binding, soluble, 3 binding proteinBlood+2.290.000
59PGLYRP1peptidoglycan recognition protein 1Blood+2.280.000
60FAM83Afamily with sequence similarity 83, member ABlood+2.270.000
61DLGAP5discs, large (Drosophila) homolog-associated protein 5Blood+2.260.000
62CENPAcentromere protein ABlood+2.240.000
63CDCA5cell division cycle associated 5Blood+2.230.000
64ARG1arginase 1Blood+2.230.000
65SLC25A10solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10Blood+2.230.000
66SLC39A4solute carrier family 39 (zinc transporter), member 4Blood+2.210.000
67CCNB2cyclin B2Blood+2.210.000
68PER1period circadian clock 1Blood+2.200.000
69GLDCglycine dehydrogenase (decarboxylating)Blood+2.190.000
70ABHD17Aabhydrolase domain containing 17ABlood+2.190.000
71EXO1exonuclease 1Blood+2.190.000
72PYCR1pyrroline-5-carboxylate reductase 1Blood+2.190.000
73LOC342541peptidylprolyl isomerase A (cyclophilin A) pseudogeneBlood+2.170.000
74SH3RF3SH3 domain containing ring finger 3Blood+2.170.000
75OLFM4olfactomedin 4Blood+2.170.000
76MATR3matrin 3Blood-2.170.000
77MAOAmonoamine oxidase ABlood+2.170.000
78MCM2minichromosome maintenance complex component 2Blood+2.170.000
79OPLAH5-oxoprolinase (ATP-hydrolysing)Blood+2.160.000
80FOXM1forkhead box M1Blood+2.160.000
81CKAP2Lcytoskeleton associated protein 2-likeBlood+2.160.000
82TPX2TPX2, microtubule-associatedBlood+2.150.000
83TPTE2P6transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 6Blood+2.150.000
84SLC2A5solute carrier family 2 (facilitated glucose/fructose transporter), member 5Blood+2.140.000
85NTSR1neurotensin receptor 1 (high affinity)Blood+2.140.000
86CACNA1Ecalcium channel, voltage-dependent, R type, alpha 1E subunitBlood+2.140.000
87PCOLCE2procollagen C-endopeptidase enhancer 2Blood+2.140.000
88MRPL4mitochondrial ribosomal protein L4Blood+2.140.000
89ABCA13ATP-binding cassette, sub-family A (ABC1), member 13Blood+2.130.000
90FAM83Hfamily with sequence similarity 83, member HBlood+2.130.000
91TOP2Atopoisomerase (DNA) II alpha 170kDaBlood+2.130.000
92METTL7Bmethyltransferase like 7BBlood+2.130.000
93CUTAcutA divalent cation tolerance homolog (E. coli)Blood+2.130.000
94GP5glycoprotein V (platelet)Blood+2.130.000
95MIR205HGMIR205 host gene (non-protein coding)Blood+2.120.000
96RAB40CRAB40C, member RAS oncogene familyBlood+2.120.000
97PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2Blood+2.120.000
98UGT2B17UDP glucuronosyltransferase 2 family, polypeptide B17Blood+2.120.000
99COG5component of oligomeric golgi complex 5Blood+2.120.000
100RNASE3ribonuclease, RNase A family, 3Blood+2.110.000
101LOC390876ribosomal protein L35 pseudogeneBlood+2.100.000
102TMEM52Btransmembrane protein 52BBlood+2.100.000
103CDCA3cell division cycle associated 3Blood+2.100.000
104IL2RGinterleukin 2 receptor, gammaBlood+2.100.000
105PLOD2procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2Blood+2.100.000
106LINC00668long intergenic non-protein coding RNA 668Blood+2.090.000
107CHEK1checkpoint kinase 1Blood+2.090.000
108LOC402644peptidylprolyl isomerase A (cyclophilin A) pseudogeneBlood+2.070.000
109ASGR2asialoglycoprotein receptor 2Blood+2.070.000
110HMMRhyaluronan-mediated motility receptor (RHAMM)Blood+2.070.000
111TTC40tetratricopeptide repeat domain 40Blood+2.070.000
112SIAEsialic acid acetylesteraseBlood+2.070.000
113ANKRD33ankyrin repeat domain 33Blood+2.070.000
114NXNnucleoredoxinBlood+2.070.000
115SLC26A8solute carrier family 26 (anion exchanger), member 8Blood+2.060.000
116DDIT4DNA-damage-inducible transcript 4Blood+2.060.000
117C2complement component 2Blood+2.050.000
118SOCS3suppressor of cytokine signaling 3Blood+2.050.000
119KIF15kinesin family member 15Blood+2.040.000
120TDRD9tudor domain containing 9Blood+2.040.000
121TCTEX1D1Tctex1 domain containing 1Blood+2.040.000
122ORM1orosomucoid 1Blood+2.040.000
123CDC45cell division cycle 45Blood+2.030.000
124CDC20cell division cycle 20Blood+2.030.000
125DDX19ADEAD (Asp-Glu-Ala-Asp) box polypeptide 19ABlood+2.030.000
126H6PDhexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)Blood+2.020.000
127COL17A1collagen, type XVII, alpha 1Blood+2.020.000
128GINS2GINS complex subunit 2 (Psf2 homolog)Blood+2.020.000
129NRF1nuclear respiratory factor 1Blood+2.020.000
130CD177CD177 moleculeBlood+2.010.000
131KRT75keratin 75Blood+2.010.000
132SLAMF8SLAM family member 8Blood+2.000.000
133SIAH2siah E3 ubiquitin protein ligase 2Blood+2.000.000
134AK7adenylate kinase 7Blood+1.990.000
135AMY1Camylase, alpha 1C (salivary)Blood+1.990.000
136PDCD1programmed cell death 1Blood+1.990.000
137LGALSLlectin, galactoside-binding-likeBlood+1.990.000
138BMP6bone morphogenetic protein 6Blood+1.980.000
139FBN2fibrillin 2Blood+1.980.000
140PCSK6proprotein convertase subtilisin/kexin type 6Blood+1.970.000
141HMGB3high mobility group box 3Blood+1.970.000
142LHFPL2lipoma HMGIC fusion partner-like 2Blood+1.970.000
143ORC1origin recognition complex, subunit 1Blood+1.970.000
144CAMTA2calmodulin binding transcription activator 2Blood+1.970.000
145KIAA0101KIAA0101Blood+1.960.000
146RASL11ARAS-like, family 11, member ABlood+1.960.000
147LCN2lipocalin 2Blood+1.960.000
148WDR66WD repeat domain 66Blood+1.950.000
149RFNGRFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseBlood+1.950.000
150MKI67marker of proliferation Ki-67Blood+1.950.000
151IKZF4IKAROS family zinc finger 4 (Eos)Blood+1.940.000
152BMXBMX non-receptor tyrosine kinaseBlood+1.940.000
153LRRC59leucine rich repeat containing 59Blood+1.940.000
154GAS6growth arrest-specific 6Blood+1.940.000
155LINC00661long intergenic non-protein coding RNA 661Blood+1.940.000
156RNF126P1ring finger protein 126 pseudogene 1Blood+1.930.000
157HMGN2P46high mobility group nucleosomal binding domain 2 pseudogene 46Blood+1.930.000
158DTLdenticleless E3 ubiquitin protein ligase homolog (Drosophila)Blood+1.930.000
159SEMA4Asema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4ABlood+1.930.000
160IL27interleukin 27Blood+1.930.000
161RAD54LRAD54-like (S. cerevisiae)Blood+1.930.000
162DYSFdysferlinBlood+1.930.000
163C7orf13chromosome 7 open reading frame 13Blood+1.920.000
164C9orf16chromosome 9 open reading frame 16Blood+1.920.000
165PCDHAC1protocadherin alpha subfamily C, 1Blood+1.920.000
166USP41ubiquitin specific peptidase 41Blood+1.920.000
167PKMYT1protein kinase, membrane associated tyrosine/threonine 1Blood+1.910.000
168PRG2proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)Blood+1.910.000
169IL1R2interleukin 1 receptor, type IIBlood+1.910.000
170MELKmaternal embryonic leucine zipper kinaseBlood+1.910.000
171SLC22A17solute carrier family 22, member 17Blood+1.910.000
172POC1APOC1 centriolar protein ABlood+1.910.000
173ALDOAaldolase A, fructose-bisphosphateBlood+1.900.000
174CC2D1Acoiled-coil and C2 domain containing 1ABlood+1.900.000
175SLX1BSLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)Blood+1.890.000
176DSCC1DNA replication and sister chromatid cohesion 1Blood+1.890.000
177IRAK3interleukin-1 receptor-associated kinase 3Blood+1.890.000
178FAM207Afamily with sequence similarity 207, member ABlood+1.890.000
179CSNK1Ecasein kinase 1, epsilonBlood+1.890.000
180SGPP2sphingosine-1-phosphate phosphatase 2Blood+1.890.000
181MARCOmacrophage receptor with collagenous structureBlood+1.890.000
182CBScystathionine-beta-synthaseBlood+1.890.000
183OIP5Opa interacting protein 5Blood+1.880.000
184CD163CD163 moleculeBlood+1.880.000
185PHGDHphosphoglycerate dehydrogenaseBlood+1.880.000
186GRNgranulinBlood+1.870.000
187OLR1oxidized low density lipoprotein (lectin-like) receptor 1Blood+1.870.003
188DERL3derlin 3Blood+1.870.000
189CTSDcathepsin DBlood+1.870.000
190SORT1sortilin 1Blood+1.870.000
191LHCGRluteinizing hormone/choriogonadotropin receptorBlood+1.870.000
192RAB25RAB25, member RAS oncogene familyBlood+1.870.000
193BUB1BUB1 mitotic checkpoint serine/threonine kinaseBlood+1.870.000
194TLR5toll-like receptor 5Blood+1.860.000
195TAL2T-cell acute lymphocytic leukemia 2Blood+1.860.000
196RNF157ring finger protein 157Blood+1.860.000
197SPSB1splA/ryanodine receptor domain and SOCS box containing 1Blood+1.850.000
198YIF1BYip1 interacting factor homolog B (S. cerevisiae)Blood+1.850.000
199YOD1YOD1 deubiquitinaseBlood+1.850.000
200MARC1mitochondrial amidoxime reducing component 1Blood+1.850.000
201MIIPmigration and invasion inhibitory proteinBlood+1.850.000
202SOX6SRY (sex determining region Y)-box 6Blood-1.820.001
203RNF6ring finger protein (C3H2C3 type) 6Blood-1.760.001
204SPASTspastinBlood-1.610.001
205IGFBP3insulin-like growth factor binding protein 3Blood-1.570.002
206NEK7NIMA-related kinase 7Blood-1.540.005
207HBZhemoglobin, zetaBlood-1.510.048
208SNX14sorting nexin 14Blood-1.460.010
209CFHcomplement factor HBlood-1.460.010
210SNRNP70small nuclear ribonucleoprotein 70kDa (U1)Blood-1.430.011
211AMY2Bamylase, alpha 2B (pancreatic)Blood-1.430.017
212ZNF136zinc finger protein 136Blood-1.410.010
213KLF10Kruppel-like factor 10Blood-1.400.019
214LRRC36leucine rich repeat containing 36Blood-1.350.007
215TRIM59tripartite motif containing 59Blood-1.310.026
216TGM2transglutaminase 2Blood-1.310.013

Expression patterns in normal tissues for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Systemic Onset Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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Pathways related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
9.4TNF, PRF1
2
Show member pathways
Immune response CD16 signaling in NK cells59
9.4PRF1, TNF
3
Show member pathways
9.4PRF1, TNF
4
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.4TNF, PRF1
5
Show member pathways
FAS pathway and Stress induction of HSP regulation37
Apoptosis and survival FAS signaling cascades59
Caspase cascade in apoptosis37
9.4PRF1, TNF
6
Show member pathways
9.3TNF, MEFV
7
Show member pathways
9.1TNF, IL10
89.1TNF, IL10
99.1TNF, IL10
10
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.1TNF, IL10
11
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.1TNF, IL10
129.1TNF, IL10
13
Show member pathways
9.1IL10, TNF
14
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
9.1IL10, TNF
159.1IL10, TNF
169.1IL10, TNF
179.1IL10, TNF
18
Show member pathways
IL27-mediated signaling events37
9.1IL10, TNF
199.1TNF, IL10
209.1IL10, TNF
219.1TNF, IL10
22
Show member pathways
8.6IL10, TNF, PRF1

Compounds for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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Compounds related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1cdp571449.6IL10, TNF
2interferon gamma449.6IL10, TNF
3blys449.6IL10, TNF
4gabexate mesilate449.6IL10, TNF
5ulinastatin449.6TNF, IL10
6toxin-1449.6TNF, IL10
7mip 1alpha449.6IL10, TNF
8natalizumab44 1210.6IL10, TNF
95 aminosalicylic acid449.6TNF, IL10
10il-12449.6TNF, IL10
11adalimumab44 50 1211.6IL10, TNF
12indoleamine449.6TNF, IL10
13imiquimod44 60 29 1212.5IL10, TNF
14cyclosporine50 1210.5IL10, TNF
15polymyxin b449.5TNF, IL10
16okt3449.5IL10, TNF
17groalpha449.5IL10, TNF
18gm-csf44 2910.5TNF, IL10
19lipoteichoic acid449.5IL10, TNF
208-isoprostane449.5IL10, TNF
212,5-oligoadenylate449.5TNF, IL10
22polyinosinic-polycytidylic acid449.5TNF, IL10
23rolipram44 60 2911.5IL10, TNF
24etanercept44 50 1211.5IL10, TNF
25mycophenolate mofetil44 50 1211.5IL10, TNF
26il 10449.5IL10, TNF
27tarc449.5TNF, IL10
28infliximab44 50 1211.5TNF, IL10
29peptidoglycan44 2910.5IL10, TNF
30ivig449.5TNF, IL10
31pentoxifylline44 1210.5IL10, TNF
32ccl344 2910.4IL10, TNF
33neopterin449.4TNF, IL10
3415-deoxy-delta-12,14-prostaglandin j2449.4IL10, TNF
35rituximab44 50 1211.4IL10, TNF
36chloroquine44 3 50 29 1213.4TNF, IL10
37thalidomide44 50 60 1212.4TNF, IL10
38prednisolone44 29 1211.4IL10, TNF
39atorvastatin44 50 29 25 1213.4IL10, TNF
40hydrocortisone44 3 60 1212.3TNF, IL10
41tgf beta1449.3IL10, TNF
42simvastatin44 50 60 29 25 1214.3IL10, TNF
43ionomycin449.2TNF, IL10
44prostacyclin449.2IL10, TNF
45tacrolimus44 50 1211.1IL10, TNF
46rantes449.1IL10, TNF
47calcitriol44 60 25 1212.0TNF, IL10
48cycloheximide449.0TNF, PRF1, IL10
49endotoxin449.0TNF, MEFV, IL10
50methotrexate50 44 1210.8IL10, TNF

GO Terms for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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Biological processes related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1receptor biosynthetic processGO:0328009.4IL10, TNF
2negative regulation of cytokine secretion involved in immune responseGO:0027409.3IL10, TNF
3negative regulation of growth of symbiont in hostGO:0441309.3IL10, TNF
4negative regulation of interleukin-12 productionGO:0326959.2IL10, MEFV
5negative regulation of interleukin-6 productionGO:0327159.2IL10, TNF
6positive regulation of cytokine secretionGO:0507159.1IL10, TNF
7positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.1IL10, TNF
8response to activityGO:0148239.0TNF, IL10
9response to glucocorticoidGO:0513848.8IL10, TNF
10inflammatory responseGO:0069548.6TNF, MEFV, IL10

Molecular functions related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL10, TNF

Products for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Systemic Onset Juvenile Idiopathic Arthritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet