MCID: SYS034
MIFTS: 40

Systemic Onset Juvenile Idiopathic Arthritis malady

Bone diseases category

Summaries for Systemic Onset Juvenile Idiopathic Arthritis

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MalaCards: Systemic Onset Juvenile Idiopathic Arthritis, also known as systemic onset juvenile rheumatoid arthritis, is related to arthritis and kawasaki disease. An important gene associated with Systemic Onset Juvenile Idiopathic Arthritis is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are Monoamine Transport and Cytosolic DNA-sensing pathway. The compounds tenidap and cycloheximide have been mentioned in the context of this disorder. Related mouse phenotypes are skeleton and integument.

Aliases & Classifications for Systemic Onset Juvenile Idiopathic Arthritis

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42NIH Rare Diseases, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

systemic onset juvenile idiopathic arthritis 42
systemic onset juvenile rheumatoid arthritis 42
systemic onset juvenile chronic arthritis 60
systemic juvenile idiopathic arthritis 42
juvenile-onset still disease 60
still's disease 42
stills disease 44


Related Diseases for Systemic Onset Juvenile Idiopathic Arthritis

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17GeneCards, 18GeneDecks
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Diseases related to Systemic Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 234)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.8IL6, IL1B, TNF
2kawasaki disease30.8CRP, S100A12
3amyloidosis30.6IL1RAPL2, MEFV, CRP
4juvenile rheumatoid arthritis30.6IL6, IL1RAPL2, IL1R1, IL1RN, CRP, TNF
5encephalitis30.4IL1B
6respiratory failure30.4IL6, IL1B, CRP, TNF
7diabetes mellitus30.4IL6, IL1B, IL1R1, CRP, TNF
8influenza30.4GZMB
9lupus erythematosus30.4IL18
10myocarditis30.4PRF1
11keratitis30.4MIF, TLR4
12hemophagocytic lymphohistiocytosis30.4RAB27A, PRF1, UNC13D
13celiac disease30.4IL18RAP, GZMB
14hepatitis30.4IL1RAPL2, IL18, GZMB
15glomerulonephritis30.4IL1B, IL1R1, IL1RN, MIF
16adult-onset still's disease30.4IL6, IL1RAPL2, IL1R1, IL18, CRP
17leukemia30.3IL6, IL1B, IL1RAPL2, IL1R1, TNF, S100A8
18systemic lupus erythematosus30.3IL6, IL1RAPL2, IL1R1, IL1RN, IL18, MIF
19rheumatoid arthritis30.3IL6, IL1B, IL1RAPL2, IL1R1, IL1RN, IL18
20pericarditis30.2MEFV
21gastric ulcer30.2S100A8
22peritonitis30.2IL6, IL1B, MEFV, CRP, TNF
23skin disease29.7IL18, TNF, S100A8, S100A9
24osteoporosis29.7SLC26A2, IL6, IL1RAPL2, IL1RN
25cardiac tamponade10.4
26hodgkin's lymphoma10.3
27acute liver failure10.3
28pure red-cell aplasia10.3
29autoimmune hepatitis10.3
30acute leukemia10.3
31hepatitis a10.3
32congestive heart failure10.3
33lymphoblastic leukemia10.3
34pericardial effusion10.3
35renal cell carcinoma10.3
36autoimmune lymphoproliferative syndrome10.2
37adult syndrome10.2
38cervicitis10.2
39gastroenteritis10.2
40brucellosis10.0MEFV
41lichen planus10.0GZMB
42liver cirrhosis10.0GZMB
43peptic ulcer10.0S100A8
44esophagitis10.0S100A8
45bronchopulmonary dysplasia10.0IL1RN
46histiocytosis10.0S100A9
47colon cancer10.0MIF
48dengue shock syndrome10.0IL1RN
49myelodysplastic syndromes10.0GZMB
50pyoderma gangrenosum10.0MEFV

Graphical network of the top 20 diseases related to Systemic Onset Juvenile Idiopathic Arthritis:



Diseases related to systemic onset juvenile idiopathic arthritis

Clinical Features for Systemic Onset Juvenile Idiopathic Arthritis

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Drugs & Therapeutics for Systemic Onset Juvenile Idiopathic Arthritis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Systemic Onset Juvenile Idiopathic Arthritis

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Anatomical Context for Systemic Onset Juvenile Idiopathic Arthritis

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Animal Models for Systemic Onset Juvenile Idiopathic Arthritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Systemic Onset Juvenile Idiopathic Arthritis:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.4UNC13D, MEFV, IL1B, IL6, SLC26A2
2MP:00107719.3TLR4, MEFV, PRF1, IL1R1, IL6
3MP:00020069.2TNF, MIF, IL1R1, IL1B, IL6
4MP:00053709.0TNF, MEFV, PRF1, IL1R1, IL6, TLR4
5MP:00053768.3TLR4, S100A9, CRP, MEFV, PRF1, IL18
6MP:00053788.0TLR4, TNF, MEFV, PRF1, IL18, IL1RN
7MP:00053857.9TLR4, TNF, CRP, IL18, IL1RN, IL1R1
8MP:00053977.4TLR4, GZMB, S100A9, TNF, UNC13D, MEFV
9MP:00053847.4MEFV, TNF, S100A9, GZMB, TLR4, PRF1
10MP:00107686.9TLR4, GZMB, S100A9, S100A8, TNF, MEFV
11MP:00053876.5RAB27A, TLR4, GZMB, S100A9, TNF, UNC13D

Publications for Systemic Onset Juvenile Idiopathic Arthritis

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Genetic Variations for Systemic Onset Juvenile Idiopathic Arthritis

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Expression for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Systemic Onset Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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37NCBI BioSystems Database, 29KEGG, 53Reactome, 52R&D Systems, 51QIAGEN, 12EMD Millipore, 59Tocris Bioscience
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Pathways related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IL1R1
210.2IL18
310.0TLR4, IL18
410.0IL18, TLR4
59.9IL1B, IL18
69.9IL1B, TLR4
79.9IL6, IL1B
8
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9.8IL18RAP, TLR4
99.8PRF1, TNF, GZMB
10
Apoptosis and survival Caspase cascade
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9.8GZMB, TNF, PRF1
11
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9.7IL1B, IL1R1, IL1RN
129.7PRF1, IL18RAP, IL18
139.7TNF, MIF, IL6
14
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9.6IL1B, IL1R1, TLR4
159.6TLR4, TNF, IL1R1
169.6TLR4, TNF, IL18
17
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9.6IL18, IL18RAP, TLR4
189.6IL1B, IL18, TNF
199.5TNF, IL1B, IL6
20
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9.5GZMB, TNF, PRF1, IL1R1
219.4TLR4, IL18, IL1B, IL6
229.3TLR4, TNF, IL1R1, IL1B
23
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9.3TLR4, TNF, IL1R1, IL1B
24
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9.3IL1B, IL1R1, TNF, TLR4
259.3TNF, IL1RN, IL1B, IL6
269.3TLR4, TNF, IL18, IL1B
279.3TNF, IL1R1, IL1B, IL6
289.3TNF, IL18, IL1B, IL6
299.3TNF, IL18, IL1B, IL6
30
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9.3TLR4, TNF, IL1B, IL6
319.3TLR4, TNF, IL1B, IL6
329.3IL6, IL1B, TNF, TLR4
339.2TNF, CRP, IL1B, IL6
34
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9.2TLR4, GZMB, IL1R1, IL1B, IL6
35
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9.1IL6, IL1B, IL1R1, IL1RN, IL18
36
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9.1IL18, IL1RN, IL1R1, IL1B, IL6
37
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9.1GZMB, IL18RAP, IL18, IL1R1, IL1B
38
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9.1TNF, MEFV, IL18, IL1B, IL6
399.0IL6, IL1B, IL1R1, TNF, TLR4
40
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9.0TLR4, TNF, IL1R1, IL1B, IL6
419.0TLR4, TNF, IL1R1, IL1B, IL6
42
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9.0IL6, IL1B, IL18, TNF, TLR4
43
Development PDGF signaling via STATs and NF-kB
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8.9TNF, IL18RAP, IL18, IL1B, IL6
44
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8.9GZMB, TNF, PRF1, IL18, IL1B, IL6
45
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8.8TLR4, TNF, MIF, IL1R1, IL1B, IL6
46
Immune response Bacterial infections in normal airways
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8.8TLR4, TNF, IL1RN, IL1R1, IL1B, IL6
47
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8.8TLR4, TNF, IL18, IL1R1, IL1B, IL6
48
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8.8TLR4, TNF, IL18, IL1R1, IL1B, IL6
49
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8.6IL6, IL1B, IL18, IL18RAP, TNF, TLR4
50
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8.3TLR4, S100A12, MEFV, IL18, IL1RN, IL1R1

Compounds for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1tenidap44 2811.6IL1R1
2cycloheximide4410.0IL18, IL1RAPL2
3rosiglitazone44 49 28 11 2413.8IL1RN, IL18, IL1R1, IL6
4endotoxin449.7S100A9, S100A8, MEFV
5pentoxifylline44 1110.5IL18, IL1RAPL2, IL1RN, IL1R1
6prednisolone44 28 1111.5GZMB, CRP, IL1R1, IL1RAPL2
7pirfenidone44 5910.5IL1B, S100A9, S100A8
8cyclosporin a44 28 5911.4GZMB, IL1RAPL2, IL1R1
9il-12449.3IL1R1, IL1B, IL6, TNF, IL18
10polysulfone449.3IL1B, IL1RAPL2, IL1RN, IL1R1
11polymyxin b449.3TLR4, IL1RN, IL1B, TNF, IL6
12peptidoglycan44 2810.1IL6, IL1B, IL1R1, IL1RN, TNF, TLR4
13git 27599.1MIF, S100A9, S100A8, IL1R1, IL1B
144-ipp599.1S100A9, S100A8, MIF, IL1B, IL1R1
15ccl344 2810.1IL6, IL1R1, IL1B, TNF, TLR4, IL18
16polyinosinic-polycytidylic acid449.1IL6, IL1B, TNF, IL18, TLR4
17as 10159 4410.1S100A9, IL1B, IL1R1, MIF, S100A8
18glucose449.0GZMB, S100A12, RAB27A, IL1RAPL2
19imiquimod44 28 59 1112.0IL6, IL1RAPL2, IL18, TNF, TLR4
20lipoteichoic acid449.0TLR4, IL1RN, IL1R1, IL1B, IL6, IL18
21adalimumab44 49 1110.9IL6, IL1RAPL2, IL1R1, IL1RN, CRP, TNF
22leflunomide49 44 1110.8IL1B, IL1RAPL2, IL1R1, TNF, IL1RN, IL6
23sulfasalazine44 28 49 1111.8IL1RAPL2, IL1R1, IL1B, CRP, IL1RN, TNF
24monosodium urate448.7IL1B, S100A9, S100A8, IL1R1, IL1RAPL2
25poly(i-c)448.7IL1B, TLR4, TNF, IL18, IL6
26atorvastatin44 49 28 11 2412.7TLR4, CRP, IL18, IL1RN, TNF, IL6
27leukotriene b444 59 2410.6IL1B, IL6, IL1R1, TNF, IL1RAPL2, IL1RN
28dexamethasone44 49 28 1111.6SLC26A2, IL6, IL1RAPL2, IL1R1, S100A8, GZMB
29simvastatin44 49 59 28 11 2413.5IL6, IL1RN, CRP, TNF, TLR4, IL18
30tgf beta1448.5IL1RAPL2, IL1RN, IL18, TNF, IL6, IL1B
31sb 20358044 599.4IL1R1, IL1RN, IL1B, MIF, CRP, IL6
32aspirin44 49 28 2411.4IL1B, TLR4, IL1RAPL2, IL18, IL1RN, IL1R1
33il 10448.4IL6, IL1B, IL1RAPL2, IL1R1, IL1RN, IL18
34etanercept44 49 1110.3IL1R1, IL1RAPL2, IL1B, IL6, IL1RN, IL18
35anakinra44 119.3TNF, IL1B, CRP, IL18, IL1RN, IL1R1
36thalidomide44 49 59 1111.3IL18, IL1R1, IL1B, IL6, S100A8, MIF
37neopterin448.1IL1B, IL1RAPL2, IL1R1, IL1RN, IL18, CRP
38rantes448.1IL6, IL1B, IL1RAPL2, IL1R1, TLR4, GZMB
39infliximab44 49 1110.1IL1RAPL2, IL1B, IL6, IL1RN, IL18, CRP
40ivig448.0GZMB, S100A12, IL6, IL1B, TNF, CRP
41lactate447.9MIF, TNF, IL1R1, IL1RN, IL18, CRP
42histamine44 28 249.9IL1B, S100A8, TNF, IL6, IL1RAPL2, IL1RN
43fibrinogen447.9CRP, TLR4, S100A9, IL1R1, IL1RAPL2, IL6
44arachidonic acid44 28 11 2410.7IL1RAPL2, S100A9, TLR4, TNF, MIF, IL1B
45vegf447.6TNF, CRP, GZMB, MIF, TLR4, IL18
46cholesterol44 28 11 2410.5S100A8, IL6, IL1RAPL2, IL1R1, TLR4, S100A9
47methotrexate44 49 119.3S100A9, S100A8, TNF, CRP, IL18, IL1RN
48lipid447.3TLR4, IL1R1, IL1RN, IL18, MIF, CRP
49nitric oxide44 11 248.9TNF, S100A8, MIF, IL18, IL1RN, IL1R1
50retinoic acid44 247.9TLR4, GZMB, IL1B, IL6, IL1RAPL2, IL1R1

GO Terms for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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16Gene Ontology
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Cellular components related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1exocytic vesicleGO:0703829.8UNC13D, RAB27A
2extracellular spaceGO:0056157.5S100A9, S100A8, TNF, CRP, MIF, IL18
3plasma membraneGO:0058867.3S100A12, S100A9, S100A8, TNF, CRP, PRF1
4extracellular regionGO:0055767.0IL6, S100A12, S100A9, S100A8, TNF, CRP

Biological processes related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idNameGO IDScoreTop Affiliating Genes
1natural killer cell degranulationGO:04332010.4UNC13D, RAB27A
2chronic inflammatory response to antigenic stimulusGO:00243910.3TNF, IL1RN
3positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:200034310.3TNF, MIF
4positive regulation of calcidiol 1-monooxygenase activityGO:06055910.2TNF, IL1B
5sequestering of triglycerideGO:03073010.2TNF, IL1B
6positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.2IL18, IL1B
7positive regulation of heterotypic cell-cell adhesionGO:03411610.2TNF, IL1B
8positive regulation of fever generationGO:03162210.1TNF, IL1B
9epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.1TNF, IL6
10positive regulation of exocytosisGO:04592110.1RAB27A, UNC13D
11positive regulation of interleukin-8 biosynthetic processGO:04541610.1TLR4, TNF
12positive regulation of interleukin-8 productionGO:03275710.1IL1B, IL18, TLR4
13acute-phase responseGO:00695310.0CRP, IL1RN, IL6
14positive regulation of chemokine biosynthetic processGO:04508010.0TNF, IL1B
15negative regulation of lipid storageGO:01088810.0TNF, CRP, IL6
16positive regulation of peptidyl-serine phosphorylationGO:03313810.0IL6, MIF, TNF
17cellular response to organic cyclic compoundGO:0714079.9IL1B, IL18, TNF
18defense response to Gram-positive bacteriumGO:0508309.9TNF, CRP, IL6
19cellular response to mechanical stimulusGO:0712609.9IL1B, IL18, TLR4
20neutrophil aggregationGO:0704889.9S100A9, S100A8
21chemokine productionGO:0326029.9S100A9, S100A8
22positive regulation of JNK cascadeGO:0463309.9IL1B, TNF, TLR4
23positive regulation of MAP kinase activityGO:0434069.9S100A12, TNF, MIF
24response to glucocorticoid stimulusGO:0513849.8IL6, IL1RN, TNF
25sequestering of zinc ionGO:0321199.8S100A9, S100A8
26MAPK cascadeGO:0001659.8IL1B, IL18, TNF
27positive regulation of ERK1 and ERK2 cascadeGO:0703749.8TLR4, TNF, MIF, IL6
28positive regulation of chemokine productionGO:0327229.8IL6, IL18, TNF, TLR4
29leukocyte migration involved in inflammatory responseGO:0025239.8S100A9, S100A8
30positive regulation of NF-kappaB import into nucleusGO:0423469.7TLR4, TNF, IL18, IL1B
31lipopolysaccharide-mediated signaling pathwayGO:0316639.7TLR4, TNF, IL18, IL1B
32positive regulation of interferon-gamma productionGO:0327299.7TLR4, TNF, IL18, IL1B
33regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.7IL1B, TNF
34positive regulation of nitric oxide biosynthetic processGO:0454299.7IL6, IL1B, TNF, TLR4
35positive regulation of interleukin-6 productionGO:0327559.7TLR4, TNF, IL1B, IL6
36chronic inflammatory responseGO:0025449.6S100A8, S100A9
37positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.6TNF, IL1B, IL6
38defense response to fungusGO:0508329.5S100A12, S100A9, S100A8
39positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431239.5TLR4, S100A12, TNF, IL1B
40response to lipopolysaccharideGO:0324969.3TLR4, S100A9, S100A8, IL6
41response to ethanolGO:0454719.3CRP, S100A8, S100A9
42activation of MAPK activityGO:0001879.2IL1B, TNF, TLR4
43defense response to bacteriumGO:0427429.2TLR4, S100A12, S100A9, S100A8
44immune responseGO:0069559.2IL1B, IL1R1, IL1RN, IL18, IL18RAP, TLR4
45neutrophil chemotaxisGO:0305939.2S100A12, S100A9, S100A8, IL1B
46activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.2S100A9, S100A8, TNF
47positive regulation of inflammatory responseGO:0507299.0TLR4, S100A12, S100A9, S100A8, IL18
48innate immune responseGO:0450878.8TLR4, S100A12, S100A9, S100A8, MEFV, MIF
49positive regulation of NF-kappaB transcription factor activityGO:0510928.3TLR4, S100A12, S100A9, S100A8, TNF, IL1B
50inflammatory responseGO:0069547.3IL6, S100A12, S100A9, S100A8, TNF, CRP

Molecular functions related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor activityGO:0049089.6IL1RAPL2, IL1R1
2Toll-like receptor 4 bindingGO:0356629.4S100A8, S100A9
3arachidonic acid bindingGO:0505449.2S100A8, S100A9
4RAGE receptor bindingGO:0507869.2S100A8, S100A9, S100A12
5cytokine activityGO:0051259.1TNF, MIF, IL18, IL1B, IL6

Products for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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Sources for Systemic Onset Juvenile Idiopathic Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet