MCID: SYS034
MIFTS: 47

Systemic Onset Juvenile Idiopathic Arthritis malady

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Systemic Onset Juvenile Idiopathic Arthritis

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Aliases & Descriptions for Systemic Onset Juvenile Idiopathic Arthritis:

Name: Systemic Onset Juvenile Idiopathic Arthritis 48
Systemic Onset Juvenile Rheumatoid Arthritis 48
 
Systemic Onset Juvenile Chronic Arthritis 68
Systemic Juvenile Idiopathic Arthritis 48

Classifications:



Summaries for Systemic Onset Juvenile Idiopathic Arthritis

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MalaCards based summary: Systemic Onset Juvenile Idiopathic Arthritis, also known as systemic onset juvenile rheumatoid arthritis, is related to macrophage activation syndrome and rheumatoid arthritis, systemic juvenile. An important gene associated with Systemic Onset Juvenile Idiopathic Arthritis is TNF (Tumor Necrosis Factor), and among its related pathways are Aryl Hydrocarbon Receptor Pathway and Transcription_Role of VDR in regulation of genes involved in osteoporosis. Affiliated tissues include neutrophil, liver and b cells, and related mouse phenotypes are hematopoietic system and immune system.

Related Diseases for Systemic Onset Juvenile Idiopathic Arthritis

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Diseases related to Systemic Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1macrophage activation syndrome11.4
2rheumatoid arthritis, systemic juvenile11.2
3arthritis10.8
4kawasaki disease10.3
5intussusception10.2IL1B, TNF
6myeloid neoplasms associated with pdgfrb rearrangement10.2MEFV, TNF
7candidiasis, familial, 4, autosomal recessive10.2MEFV, TNF
8stocco dos santos syndrome10.2IL1B, TNF
9hypotrichosis-lymphedema-telangiectasia-renal defect syndrome10.2IL1B, TNF
10twin-to-twin transfusion syndrome10.2IL1B, TNF
11warthin tumor10.2IL1B, TNF
12anal paget's disease10.2IL1B, TNF
13tetanus10.2MEFV, TNF
14cataract10.2IL1B, TNF
15hepatic encephalopathy10.2IL1B, TNF
16mechanical lagophthalmos10.2MEFV, TNF
17bipolar i disorder10.2IL1B, TNF
18human immunodeficiency virus infectious disease10.2IL1B, TNF
19cerebellar disease10.2IL1B, TNF
20tinea capitis10.2IL1B, TNF
21amyotrophic lateral sclerosis type 1410.2IL1B, TNF
22measles10.2IL1B, TNF
23parkinson disease 1110.2IL1B, TNF
24dextrocardia10.2IL1B, TNF
25hypoparathyroidism-retardation-dysmorphism syndrome10.2IL1B, TNF
26gastroduodenal crohn's disease10.2IL1B, TNF
27childhood endodermal sinus tumor10.2IL1B, TNF
28dermatomycosis10.2MEFV, TNF
29mikulicz disease10.2IL1B, TNF
30senile reticular retinal degeneration10.2IL1B, TNF
31malignant histiocytosis10.2MEFV, TNF
32rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies10.2IL1B, TNF
33ectodermal dysplasia bartalos type10.2IL1B, TNF
34mineral metabolism disease10.2IL1B, TNF
35migraine with aura10.2IL1B, TNF
36histiocytoma10.2MEFV, TNF
37rickettsialpox10.2IL1B, TNF
38autosomal recessive type iv ehlers-danlos syndrome10.2IL1B, TNF
39bladder signet ring cell adenocarcinoma10.2IL1B, TNF
40neuropathy10.2IL1B, TNF
41muckle-wells syndrome10.2IL1B, MEFV
42retinal cancer10.2IL1B, MEFV
43keratoconus10.2IL1B, TNF
44motility-related diarrhea10.2IL1B, TNF
45splenic artery aneurysm10.2IL1B, TNF
46urticaria10.2IL1B, TNF
47wound botulism10.2IL1B, TNF
48strawberry gallbladder10.2MEFV, TNF
49ovarian cystic teratoma10.2IL1B, TNF
50central nervous system lymphoma10.2IL1B, TNF

Graphical network of the top 20 diseases related to Systemic Onset Juvenile Idiopathic Arthritis:



Diseases related to systemic onset juvenile idiopathic arthritis

Symptoms & Phenotypes for Systemic Onset Juvenile Idiopathic Arthritis

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MGI Mouse Phenotypes related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.3IL18, IL1B, MEFV, PRF1, TNF
2MP:00053878.3IL18, IL1B, MEFV, PRF1, TNF
3MP:00107717.5IL18, IL1B, MEFV, PRF1, TNF

Drugs & Therapeutics for Systemic Onset Juvenile Idiopathic Arthritis

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Drugs for Systemic Onset Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Liver ExtractsPhase 44067
2
Prednisoneapproved, vet_approvedPhase 3139853-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
 
Juvason
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
3
AlendronateapprovedPhase 2, Phase 3162121268-17-5, 66376-36-12088
Synonyms:
(4-Amino-1-hydroxybutylidene)bisphosphonic acid
(4-Amino-1-hydroxybutylidene)diphosphonic acid
(4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid
(4-amino-1-hydroxybutane-1,1-diyl)bis(phosphonic acid)
(4-amino-1-hydroxybutylidene)bisphosphonic acid
121268-17-5 (mono-hydrochloride salt, trihydrate)
1yhm
4-Amino-1-hydroxybutane-1,1-diphosphonate
4-Amino-1-hydroxybutane-1,1-diphosphonic Acid
4-Amino-1-hydroxybutylidene-1,1-bis(phosphonic acid)
4-Amino-1-hydroxybutylidene-1,1-bisphosphonate
4-amino-1-hydroxybutane-1,1-diphosphonic acid
66376-36-1
ABDP
AC1L1CW3
AKOS001015793
ALENDRONATE SODIUM
ALENDRONIC ACID
Acide Alendronique
Acide Alendronique [INN-French]
Acide alendronique
Acide alendronique [INN-French]
Acido Alendronico
Acido Alendronico [INN-Spanish]
Acido alendronico
Acido alendronico [INN-Spanish]
Acidum Alendronicum
Acidum Alendronicum [INN-Latin]
Acidum alendronicum
Acidum alendronicum [INN-Latin]
Adronat
 
Alendronate
Alendronate Sodium
Alendronate sodium hydrate
Alendronic acid
Alendronic acid (INN)
Alendronic acid [INN:BAN]
Alendros
Arendal
BIDD:GT0180
C07752
CHEBI:2567
CHEMBL870
CID2088
D07119
DB00630
Fosamax
Fosamax Plus D
HSCI1_000337
LS-106421
MK 217
MK-217
MolPort-000-421-410
NCGC00096054-01
NCGC00096054-03
NCGC00096054-04
Onclast
Oprea1_422906
Phosphonic acid, (4-amino-1-hydroxybutylidene)bis
SPECTRUM1505166
ST50036159
UNII-X1J18R4W8P
alendronate
bisphosphonate, 65
4
MethotrexateapprovedPhase 315511959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
5
BenzocaineapprovedPhase 320161994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthone
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Bensokain
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Caswell No. 430A
Chloraseptic
D001566
D00552
DB01086
Dermoplast
Diet Ayds
DivK1c_000932
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
 
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Formate, Benzocaine
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Hurricaine
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Keloform
LS-35847
MLS001331704
MLS002153970
Methanesulfonate, Benzocaine
MolPort-000-871-526
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Norcain
Norcaine
Norcainum
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orthesin
Otocain
Outgro
Parathesin
Parathesin (TN)
Parathesine
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Topcaine
UNII-U3RSY48JW5
WLN: ZR DVO2
ZINC12358719
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
6
Tofacitinibapproved, investigationalPhase 3108477600-75-2
Synonyms:
 
Tasocitinib
Tofacitinibum
7
Etanerceptapproved, investigationalPhase 3403185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
8
Folic Acidapproved, nutraceutical, vet_approvedPhase 3439259-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
9tannic acidapproved, NutraceuticalPhase 32016
10
leucovorinapproved, NutraceuticalPhase 3323558-05-954575, 6560146, 143
Synonyms:
(5-formyl-5,6,7,8-tetrahydropteroyl)glutamate
(6R,S)-5-Formyltetrahydrofolate
10-Formyl-7,8-dihydrofolate
10-Formyl-7,8-dihydrofolic acid
5-Formyl-5,6,7,8-tetrahydrofolate
5-Formyl-5,6,7,8-tetrahydrofolic acid
5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
5-Formyltetrahydrofolate
5-Formyltetrahydrofolic acid
5-Formyltetrahydropteroylglutamate
5-Formyltetrahydropteroylglutamic acid
5-formyltetrahydrofolic acid
Acide folinique
Calcium citrovorum factor
Calcium folinate
Citrovorum factor
Folinate
Folinic acid
Folinic acid calcium salt
 
Folinic acid calcium salt USP27
Folinic acid-SF
L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid
L-Leucovorin
L-N-[p-[[(2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-Glutamic acid
L-leucovorin
Leucal
Leucovorin calcium
Leucovorin folinic acid
Leucovorinum
Leukovorin
Levoleucovorin
N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
N5-Formyl-5,6,7,8-tetrahydrofolate
N5-Formyl-5,6,7,8-tetrahydrofolic acid
N5-Formyl-THF
N5-Formyltetrahydrofolate
N5-Formyltetrahydrofolic acid
Welcovorin
Wellcovorin
folinate
11Vitamin B ComplexPhase 34337
12Nucleic Acid Synthesis InhibitorsPhase 34962
13Peripheral Nervous System AgentsPhase 323689
14gamma-GlobulinsPhase 3326
15Pharmaceutical SolutionsPhase 3, Phase 2, Phase 18192
16Rho(D) Immune GlobulinPhase 3326
17Immunoglobulins, IntravenousPhase 3333
18glucocorticoidsPhase 2, Phase 35103
19Bone Density Conservation AgentsPhase 2, Phase 33376
20Immunosuppressive AgentsPhase 313086
21ImmunoglobulinsPhase 3, Phase 1, Phase 26394
22Folic Acid AntagonistsPhase 32257
23Antibodies, MonoclonalPhase 3, Phase 1, Phase 24039
24AntibodiesPhase 3, Phase 1, Phase 26394
25Antirheumatic AgentsPhase 2, Phase 310956
26Interleukin 1 Receptor Antagonist ProteinPhase 2, Phase 399
27Analgesics, Non-NarcoticPhase 36501
28AnalgesicsPhase 311733
29Antimetabolites, AntineoplasticPhase 37361
30AntimetabolitesPhase 312054
31Dermatologic AgentsPhase 35806
32Anti-Inflammatory Agents, Non-SteroidalPhase 34443
33Anti-Inflammatory AgentsPhase 310729
34Protein Kinase InhibitorsPhase 33689
35Gastrointestinal AgentsPhase 38402
36FolateNutraceuticalPhase 34392
37Vitamin B9NutraceuticalPhase 34392
38Histone Deacetylase InhibitorsPhase 2569
39Givinostat hydrochloridePhase 211
40Rheumatoid Factor6

Interventional clinical trials:

(show all 34)
idNameStatusNCT IDPhase
1A Study of Decreased Dose Frequency in Participants With Systemic Juvenile Arthritis Who Experience Laboratory Abnormalities During Treatment With RoActemra/Actemra (Tocilizumab)RecruitingNCT01734382Phase 4
2Interleukin-1 Receptor Antagonist (IL-1RA) (ANAKINRA) IN SEVERE SYSTEMIC-ONSET JUVENILE IDIOPATHIC ARTHRITISCompletedNCT00339157Phase 2, Phase 3
3An Open-label Extension Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis and Active Systemic Manifestations Manifestations and Response Characterization Study in Canakinumab Treatment-naïve Patients With Active SJIA With and WiCompletedNCT00891046Phase 3
4Flare Prevention Study of Canakinumab in Patients With Active Systemic Juvenile Idiopathic Arthritis (SJIA)CompletedNCT00889863Phase 3
5A Study of RoActemra/Actemra (Tocilizumab) in Patients With Active Systemic Juvenile Idiopathic Arthritis (JIA)CompletedNCT00642460Phase 3
6Study of MRA for Systemic Juvenile Idiopathic Arthritis (sJIA)CompletedNCT00144599Phase 3
7Long-term Treatment Study of MRA for Systemic Juvenile Idiopathic Arthritis (sJIA)CompletedNCT00144612Phase 3
8Alendronate Osteoporosis StudyCompletedNCT00277251Phase 2, Phase 3
9Study of MRA for Polyarticular Juvenile Idiopathic Arthritis (pJIA)CompletedNCT00144664Phase 3
10Treatment of Childhood Onset Psychiatric Disorders With Intravenous Immunoglobulin (IVIg)CompletedNCT00001768Phase 3
11A Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis or Hereditary Periodic Fevers Who Participated in the CACZ885G2301E1, CACZ885G2306 or CACZ885N2301 StudiesRecruitingNCT02334748Phase 3
12ß-SPECIFIC 4 Patients: Study of Pediatric EffiCacy and Safety wIth FIrst-line Use of CanakinumabRecruitingNCT02296424Phase 3
13Study of Efficacy and Safety of Canakinumab in Japanese Patients With SJIAActive, not recruitingNCT02396212Phase 3
14A Safety, Efficacy And Pharmacokinetics Study Of Tofacitinib In Pediatric Patients With sJIANot yet recruitingNCT03000439Phase 3
15Safety and Efficacy Study of Etanercept (Enbrel®) In Children With Systemic Onset Juvenile Rheumatoid ArthritisTerminatedNCT00078806Phase 3
16Single-dose Study to Assess Efficacy of Canakinumab (ACZ885) in Patients With Active Juvenile Idiopathic Arthritis (SJIA)TerminatedNCT00886769Phase 3
17An Open-label, Multi-arm, Non-comparative Safety and Tolerability Study of Canakinumab (ACZ885) in Patients With Active Systemic Juvenile Idiopathic Arthritis (SJIA)WithdrawnNCT01676948Phase 3
18Phase II, Open Label, International, Multicentre Clinical Trial to Investigate Safety and Efficacy of Oral ITF2357 in Patients With Active Systemic Onset Juvenile Idiopathic Arthritis (SOJIA)CompletedNCT00570661Phase 2
19Safety and Effectiveness of Rilonacept for Treating Systemic Juvenile Idiopathic Arthritis in Children and Young AdultsCompletedNCT00534495Phase 2
20Safety, Efficacy and Pharmacokinetics of Subcutaneous ACZ885 in Patients With Systemic Juvenile Idiopathic Arthritis (SJIA)CompletedNCT00426218Phase 1, Phase 2
21Ilaris (Canakinumab) in the Schnitzler SyndromeCompletedNCT01245127Phase 2
22A Repeated Dose-finding Study of Sarilumab in Children and Adolescents With Systemic Juvenile Idiopathic Arthritis (sJIA)RecruitingNCT02991469Phase 2
23Tocilizumab in Patients With Schnitzler's SyndromeNot yet recruitingNCT03046381Phase 2
24Study to Evaluate the Safety and Tolerability of Two Doses of Rilonacept in Pediatric Subjects With Active Systemic Juvenile Idiopathic Arthritis (SJIA)CompletedNCT01803321Phase 1
25An Open-Label Trial of Tocilizumab in SchizophreniaCompletedNCT01696929Phase 1
26Extension Study Evaluating the Safety and Efficacy of Subcutaneous Tocilizumab (RoActemra/Actemra) Administration in Systemic and Polyarticular-Course Juvenile Idiopathic ArthritisRecruitingNCT02165345Phase 1
27A Study to Evaluate the Pharmacokinetic and Safety of Tocilizumab (RoActemra/Actemra) in Participants Less Than 2 Years Old With Active Systemic Juvenile Idiopathic ArthritisActive, not recruitingNCT01455701Phase 1
28A Study of Subcutaneously Administered Tocilizumab in Participants With Systemic Juvenile Idiopathic ArthritisActive, not recruitingNCT01904292Phase 1
29Tocilizumab in SchizophreniaNot yet recruitingNCT02874573Phase 1
30New Candidate Criteria for Diagnosis of Macrophage Activation SyndromeUnknown statusNCT01095146
31Ultrasonography in Juvenile Idiopathic ArthritisCompletedNCT01304420Early Phase 1
32The CARRA RegistryCompletedNCT01697254
33Observational Study of Pediatric Rheumatic Diseases: The CARRA RegistryRecruitingNCT02418442
34Single Patient Use of Tocilizumab in Systemic Onset Juvenile Idiopathic ArthritisTerminatedNCT00868751

Search NIH Clinical Center for Systemic Onset Juvenile Idiopathic Arthritis

Genetic Tests for Systemic Onset Juvenile Idiopathic Arthritis

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Anatomical Context for Systemic Onset Juvenile Idiopathic Arthritis

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MalaCards organs/tissues related to Systemic Onset Juvenile Idiopathic Arthritis:

36
Neutrophil, Liver, B cells, Myeloid, Heart

Publications for Systemic Onset Juvenile Idiopathic Arthritis

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Articles related to Systemic Onset Juvenile Idiopathic Arthritis:

(show top 50)    (show all 113)
idTitleAuthorsYear
1
Operative stabilization of the remaining mobile segment in ankylosed cervical spine in systemic onset - juvenile idiopathic arthritis: A case report. (27458558)
2016
2
Systemic-onset juvenile idiopathic arthritis or incomplete Kawasaki disease: a diagnostic challenge. (27782865)
2016
3
Systemic-onset juvenile idiopathic arthritis. (27392503)
2016
4
IL-6 blockers in systemic onset juvenile idiopathic arthritis. (26642378)
2016
5
Assessment of vascular function in systemic onset juvenile idiopathic arthritis. (27075461)
2016
6
Should 2016 Criteria for Macrophage Activation Syndrome be applied in children with Kawasaki disease, as well as with systemic-onset juvenile idiopathic arthritis? (26965982)
2016
7
Systemic onset juvenile idiopathic arthritis and exposure to fine particulate air pollution. (27607024)
2016
8
Myositis as a presenting feature of systemic onset juvenile idiopathic arthritis. (25677488)
2015
9
Successful treatment with tocilizumab every 4A weeks of a low disease activity group who achieve a drug-free remission in patients with systemic-onset juvenile idiopathic arthritis. (25685108)
2015
10
Bullous Erythema Nodosum Leprosum masquerading as systemic onset juvenile idiopathic arthritis: A case report. (26964436)
2015
11
Systemic onset juvenile idiopathic arthritis with macrophage activation syndrome and coronary artery dilatation misdiagnosed as Kawasaki disease. (27411422)
2015
12
Diagnosis of Systemic-Onset Juvenile Idiopathic Arthritis after Treatment for Presumed Kawasaki Disease. (25771391)
2015
13
Successful treatment of macrophage activation syndrome due to systemic onset juvenile idiopathic arthritis with antithymocyte globulin. (26210998)
2015
14
Reversible posterior leukoencephalopathy syndrome secondary to systemic-onset juvenile idiopathic arthritis: A case report and review of the literature. (25469247)
2015
15
Effect of etanercept on refractory systemic-onset juvenile idiopathic arthritis. (25754755)
2015
16
Potential Effects of Interleukins on the Pathogenesis of Systemic Onset Juvenile Idiopathic Arthritis. (26810447)
2015
17
A safety evaluation of canakinumab for the treatment of systemic onset juvenile idiopathic arthritis. (26568054)
2015
18
A130: Is the CCR5-delta32 Mutation Protective Against Systemic-Onset Juvenile Idiopathic Arthritis? (24677884)
2014
19
Discrepancy between clinical and radiological responses to tocilizumab treatment in patients with systemic-onset juvenile idiopathic arthritis. (24786929)
2014
20
Soluble CD25 in serum: a potential marker for subclinical macrophage activation syndrome in patients with active systemic onset juvenile idiopathic arthritis. (24417800)
2014
21
Coronary artery abnormalities in children with systemic-onset juvenile idiopathic arthritis. (24793086)
2014
22
Atopy in children with systemic onset juvenile idiopathic arthritis (SoJIA) is associated with a worse outcome. (24611751)
2014
23
MEFV mutations in egyptian children with systemic-onset juvenile idiopathic arthritis. (24862656)
2014
24
Pathogenesis of systemic inflammatory diseases in childhood: "Lessons from clinical trials of anti-cytokine monoclonal antibodies for Kawasaki disease, systemic onset juvenile idiopathic arthritis, and cryopyrin-associated periodic fever syndrome (24842480)
2014
25
Systemic onset juvenile idiopathic arthritis with macrophage activation syndrome misdiagnosed as Kawasaki disease: case report and literature review. (21132551)
2013
26
Congestive heart failure: an uncommon presentation of systemic onset juvenile idiopathic arthritis (SOJIA). (22161583)
2013
27
Systemic-onset juvenile idiopathic arthritis and HLA-B27 juvenile-onset undifferentiated spondyloarthritis in the same patient. (23295075)
2013
28
Anakinra pharmacokinetics in children and adolescents with systemic-onset juvenile idiopathic arthritis and autoinflammatory syndromes. (23915458)
2013
29
AA amyloidosis associated with systemic-onset juvenile idiopathic arthritis. (23664546)
2013
30
Thalidomide for systemic onset juvenile idiopathic arthritis. (23474929)
2013
31
Incomplete Kawasaki disease followed by systemic onset juvenile idiopathic arthritis- the diagnostic dilemma. (23054859)
2013
32
Nodular regenerative hyperplasia of the liver as a complication of long-standing systemic-onset juvenile idiopathic arthritis. (24315465)
2013
33
Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist. (22490470)
2012
34
Systemic-onset juvenile idiopathic arthritis: the changing life of a rare disease. (22573189)
2012
35
Development of germinoma during the treatment of systemic-onset juvenile idiopathic arthritis with infliximab. (22072226)
2012
36
Anakinra: a safe and effective first-line treatment in systemic onset juvenile idiopathic arthritis (SoJIA). (22083619)
2012
37
Macrophage activation syndrome in children with systemic onset juvenile idiopathic arthritis: clinical experience from northwest India. (21221591)
2012
38
ANCA-associated glomerulonephritis in systemic-onset juvenile idiopathic arthritis. (22189036)
2012
39
Acute liver failure in young children with systemic-onset juvenile idiopathic arthritis without macrophage activation syndrome: report of two cases. (22050445)
2012
40
Pure red cell aplasia in systemic onset juvenile idiopathic arthritis. (23448798)
2012
41
The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis. (22267331)
2012
42
Recurrent cardiac tamponade in a child with newly diagnosed systemic-onset juvenile idiopathic arthritis. (22955481)
2012
43
Systemic-onset juvenile idiopathic arthritis complicated by early onset amyloidosis in a patient carrying a mutation in the MEFV gene. (20044784)
2012
44
Initial manifestations and clinical course of systemic onset juvenile idiopathic arthritis: a ten-year retrospective study. (23089689)
2012
45
Safety and response to influenza vaccine in patients with systemic-onset juvenile idiopathic arthritis receiving tocilizumab. (22322589)
2012
46
Leflunomide in systemic onset Juvenile idiopathic arthritis. (23024081)
2012
47
Renal cell carcinoma and systemic onset juvenile idiopathic arthritis. (23250291)
2011
48
De novo 19q13.42 duplications involving NLRP gene cluster in a patient with systemic-onset juvenile idiopathic arthritis. (21326309)
2011
49
Case of systemic-onset juvenile idiopathic arthritis complicated with sepsis --usefulness of cytokine profile for the differentiation between macrophage activation syndrome and sepsis]. (21628853)
2011
50
Cardiac tamponade in a child with systemic-onset juvenile idiopathic arthritis: dramatic improvement after interleukin-1 blockade by anakinra. (21544583)
2011

Variations for Systemic Onset Juvenile Idiopathic Arthritis

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Expression for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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LifeMap Discovery
Genes differentially expressed in tissues of Systemic Onset Juvenile Idiopathic Arthritis patients vs. healthy controls: 35 (show all 6)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1PRTN3proteinase 3Blood+3.610.000
2AZU1azurocidin 1Blood+3.540.000
3MPOmyeloperoxidaseBlood+3.340.000
4ELANEelastase, neutrophil expressedBlood+3.310.000
5DEFA4defensin, alpha 4, corticostatinBlood+3.240.000
6GPER1G protein-coupled estrogen receptor 1Blood+3.070.000

Search GEO for disease gene expression data for Systemic Onset Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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Pathways related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 37)
idSuper pathwaysScoreTop Affiliating Genes
19.5IL1B, TNF
29.5IL1B, TNF
3
Show member pathways
9.5IL1B, TNF
49.5IL1B, TNF
59.5IL1B, TNF
69.5IL1B, TNF
79.5IL1B, TNF
89.5IL1B, TNF
99.5IL1B, TNF
10
Show member pathways
9.5IL1B, TNF
119.5IL1B, TNF
12
Show member pathways
9.4PRF1, TNF
13
Show member pathways
9.1IL18, IL1B
149.1IL18, IL1B
159.1IL18, IL1B
169.0IL18, PRF1
17
Show member pathways
8.9IL1B, PRF1, TNF
188.7IL18, IL1B, TNF
19
Show member pathways
8.7IL18, IL1B, TNF
208.7IL18, IL1B, TNF
218.7IL18, IL1B, TNF
228.7IL18, IL1B, TNF
23
Show member pathways
8.7IL18, IL1B, TNF
248.7IL18, IL1B, TNF
258.7IL18, IL1B, TNF
268.7IL18, IL1B, TNF
278.7IL18, IL1B, TNF
288.7IL18, IL1B, TNF
29
Show member pathways
8.7IL18, IL1B, TNF
308.7IL18, IL1B, TNF
318.7IL18, IL1B, TNF
328.7IL18, IL1B, TNF
33
Show member pathways
8.7IL18, IL1B, TNF
34
Show member pathways
8.7IL18, IL1B, TNF
35
Show member pathways
8.7IL18, IL1B, TNF
368.6IL18, IL1B, MEFV
37
Show member pathways
8.2IL18, IL1B, MEFV, TNF

GO Terms for genes affiliated with Systemic Onset Juvenile Idiopathic Arthritis

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Biological processes related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.2IL1B, TNF
2negative regulation of lipid catabolic processGO:005099510.2IL1B, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:006055910.2IL1B, TNF
4positive regulation of chemokine biosynthetic processGO:004508010.2IL1B, TNF
5positive regulation of fever generationGO:003162210.2IL1B, TNF
6positive regulation of heterotypic cell-cell adhesionGO:003411610.2IL1B, TNF
7positive regulation of interleukin-6 productionGO:003275510.1IL1B, TNF
8positive regulation of interleukin-8 productionGO:003275710.1IL1B, TNF
9positive regulation of JNK cascadeGO:004633010.1IL1B, TNF
10positive regulation of membrane protein ectodomain proteolysisGO:005104410.1IL1B, TNF
11positive regulation of nitric oxide biosynthetic processGO:004542910.1IL1B, TNF
12positive regulation of phagocytosisGO:005076610.1IL1B, TNF
13protein kinase B signalingGO:004349110.0IL1B, TNF
14regulation of establishment of endothelial barrierGO:190314010.0IL1B, TNF
15regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.0IL1B, TNF
16negative regulation of myoblast differentiationGO:00456629.9IL18, TNF
17positive regulation of granulocyte macrophage colony-stimulating factor productionGO:00327259.8IL18, IL1B
18positive regulation of protein kinase B signalingGO:00518979.8IL18, TNF
19positive regulation of smooth muscle cell proliferationGO:00486619.7IL18, TNF
20regulation of insulin secretionGO:00507969.6IL1B, TNF
21sequestering of triglycerideGO:00307309.5IL1B, TNF
22cellular response to organic cyclic compoundGO:00714079.4IL18, IL1B, TNF
23immune responseGO:00069559.4IL18, IL1B, TNF
24lipopolysaccharide-mediated signaling pathwayGO:00316639.4IL18, IL1B, TNF
25MAPK cascadeGO:00001659.3IL18, IL1B, TNF
26positive regulation of interferon-gamma productionGO:00327299.3IL18, IL1B, TNF
27positive regulation of NF-kappaB import into nucleusGO:00423469.3IL18, IL1B, TNF
28inflammatory responseGO:00069548.9IL18, IL1B, MEFV, TNF

Molecular functions related to Systemic Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.7IL18, IL1B, TNF

Sources for Systemic Onset Juvenile Idiopathic Arthritis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet