Systemic Scleroderma malady

MedlinePlus: Scleroderma means hard skin. it is a group of diseases that causes abnormal growth of connective tissue, the proteins that support your skin and organs. there are two main types. localized scleroderma affects only your skin. systemic scleroderma affects your blood vessels and internal organs, as well as your skin. symptoms of scleroderma include calcium deposits in connective tissues raynaud's phenomenon, narrowing of blood vessels in the hands or feet swelling of the esophagus, the tube between your throat and stomach thick, tight skin on your fingers red spots on your hands and face no one knows what causes scleroderma. it is more common in women. it can be mild or severe. there is no cure, but various treatments can relieve symptoms. nih: national institute of arthritis and musculoskeletal and skin diseases²³

MalaCards: Systemic Scleroderma, also known as scleroderma, is related to relapsing-remitting multiple sclerosis and localized scleroderma. An important gene associated with Systemic Scleroderma is FBLL1 (fibrillarin-like 1), and among its related pathways are PTEN Pathway and Lymphocyte Signaling. The drugs chloroquine and epoprostenol and the compounds polyethylene glycol and budesonide have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and lung, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Disease Ontology: A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.⁶

Genetics Home Reference: Systemic scleroderma is an autoimmune disorder that affects the skin and internal organs. Autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. The word "scleroderma" means hard skin in Greek, and the condition is characterized by the buildup of scar tissue (fibrosis) in the skin and other organs. The condition is also called systemic sclerosis because the fibrosis can affect organs other than the skin. Fibrosis is due to the excess production of a tough protein called collagen, which normally strengthens and supports connective tissues throughout the body.¹⁷

Wikipedia: Systemic sclerosis or systemic scleroderma is a systemic autoimmune disease or systemic connective...⁴⁴ more...

Aliases & Descriptions:

systemic scleroderma 6 17 8 43 scleroderma 6 17 23 43 pss (progressive systemic sclerosis) 6 scleroderma, familial progressive 43 familial progressive scleroderma 17 progressive systemic sclerosis 6 progressive scleroderma 17 peeling skin syndrome 43

scleroderma syndrome 6 scleroderma (& ) 6 diffuse scleroderma 43 scleroderma disease 32 systemic sclerosis 6 sclerosis systemic 32 sclerosis 43

Diseases related to systemic scleroderma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 898)

id	Related Disease	Score	Top Affiliating Genes
1	relapsing-remitting multiple sclerosis	33.6	IL4, IL6, IFNG, ICAM1
2	localized scleroderma	32.8	CD40LG, MMP1, IL4, FBN1, CTGF, TGFB1
3	optic neuritis	32.2	CD40LG, APOH, ICAM1, HSPG2
4	limited scleroderma	29.6	CENPA, CENPB, CENPC1
5	neuritis	29.2	CD40LG, MIF, INS, IL4, APOH, IFNG
6	collagen disease	28.6	SFTPD, APOH, COL1A1
7	telangiectasis	28.6	CENPB, FBL, FBN1
8	encephalomyelitis	28.2	PDE4A, KITLG, VEGFA, CD40LG, MMP1, IL4
9	polymyositis	28.2	SFTPD, SELE, VEGFA, IL4, FBL, IFNG
10	cardiac tamponade	28.0	CD40LG, HSPG2, CRP, ADA
11	calcinosis	27.7	KITLG, CENPB, FBN1, APITD1
12	keloids	27.6	MMP1, CTGF, SMAD3, TGFB1
13	pericarditis	27.6	IL6, HSPG2, CRP, ADA
14	critical limb ischemia	27.5	SELE, VEGFA, IL6, APOH, EDN1, ACE
15	autoimmune thyroiditis	27.4	IL4, IFNG, ICAM1, TPO
16	nephrosclerosis	27.3	INS, CTGF, ACE, TGFB1
17	allergic encephalomyelitis	27.3	IL4, IL6, IFNG, ICAM1, TGFB1, STAT4
18	multifocal motor neuropathy	27.2	CD40LG, IL4, IFNG
19	connective tissue disease	27.1	SFTPD, CENPB, FBL, FBN1, APOH, HSPG2
20	hypoglycemia	27.0	VEGFA, MIF, INS, IL6, ACE, PRL
21	poliomyelitis	26.8	CD40LG, IL4, IFNG, ICAM1
22	polycystic kidney disease	26.7	SELE, VEGFA, INS, FBN1, EDN1, EDNRA
23	myositis	26.7	INS, IL6, FBL, IFNG, ICAM1, TRIM21
24	lymphopenia	26.6	INS, IL4, IL6, IFNG, ADA
25	skin disease	26.6	PDE4A, SFTPD, SELE, MMP1, IL4, IFNG
26	nephrogenic systemic fibrosis	26.5	CTGF, SMAD3, TGFB1
27	infectious mononucleosis	26.5	CD40LG, IL6, APOH, IFNG, CRP
28	muscular atrophy	26.4	FBL, IFNG, HSPG2, TOP1, TGFB1, PRL
29	mixed connective tissue disease	26.4	CENPB, CD40LG, INS, IL6, FBN1, APOH
30	silicosis	26.4	SFTPD, IL6, ACE, TOP1, TGFB1
31	idiopathic interstitial pneumonia	26.3	SFTPD, VEGFA, ICAM1, CTGF, EDN1, TGFB1
32	hemolytic-uremic syndrome	26.3	SELP, CD40LG, INS, IL6, APOH, CRP
33	hepatitis c	26.2	CD40LG, MMP1, IL4, IFNG, TGFB1
34	reactive arthritis	26.2	SELE, MMP1, IL6, IFNG, CRP
35	ehlers-danlos syndrome	26.1	FBN1, PLOD2, COL1A1, COL1A2
36	central nervous system lymphoma	26.1	VEGFA, CD40LG, IL4, TOP1
37	myelitis	26.0	CD40LG, IL6, APOH
38	crescentic glomerulonephritis	26.0	KITLG, ICAM1, CTGF, CRP, TGFB1
39	autoimmune hepatitis	25.9	CD40LG, IL4, IL6, IFNG, HSPG2, TPO
40	dementia	25.9	PDE4A, SFTPD, SELP, VEGFA, MMP1, MIF
41	aortic disease	25.8	MMP1, IL6, FBN1
42	poems syndrome	25.8	VEGFA, IL6, CRP, PRL
43	respiratory failure	25.8	SFTPD, INS, IL6, IFNG, ICAM1, CRP
44	polyneuropathy	25.8	VEGFA, CD40LG, INS, IL6, HSPG2, CRP
45	pulmonary plasma cell granuloma	25.7	SFTPD, MIF, IFNG, ACE, ADA
46	behcet's disease	25.7	SELE, APOH, HSPG2, CRP, ADA
47	aseptic meningitis	25.7	IL4, IFNG, ADA
48	interstitial lung disease	25.6	SFTPD, SELE, IL4, IL6, IFNG, ICAM1
49	astrocytoma	25.6	VEGFA, MMP1, IL4, IL6, IFNG, ICAM1
50	was-related disorders	25.6	INS, IL6, FBN1, CRP, COL1A1, TGFB1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 chloroquine, chloroquine hydrochloride, chloroquine phosphate, epoprostenol, epoprostenol sodium, potassium para-aminobenzoate, tolazoline, tolazoline hydrochloride

MalaCards organs/tissues related to systemic scleroderma:

²²

MGI Mouse Phenotypes related to systemic scleroderma:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.0	ADA, GIT2, FBN1, SELP, SFTPD
2	endocrine/exocrine gland phenotype	MP:0005379	9.8	EDNRA, HOXD13, IFNG, CD40LG, CENPB
3	renal/urinary system phenotype	MP:0005367	9.5	EDNRA, TRIM21, HOXD13, FBN1, INS, SELP
4	craniofacial phenotype	MP:0005382	9.3	EDNRA, EDN1, SMAD3, HSPG2, FBN1, CENPA
5	hematopoietic system phenotype	MP:0005397	9.2	ADA, STAT4, TGFBI, COL1A1, TRIM21, GIT2
6	embryogenesis phenotype	MP:0005380	9.0	PRL, COL1A1, SRC, HOXD13, FBN1, FBL
7	skeleton phenotype	MP:0005390	7.9	CTGF, SMAD3, COL1A2, ADA, SRC, HOXD13
8	limbs/digits/tail phenotype	MP:0005371	7.9	COL1A2, COL1A1, SMAD3, CTGF, SRC, HOXD13
9	liver/biliary system phenotype	MP:0005370	7.9	ADA, PRL, SMAD3, HSPG2, IFNG, IL6
10	digestive/alimentary phenotype	MP:0005381	7.5	TGFB1, EDNRA, EDN1, COL1A1, SMAD3, CTGF
11	integument phenotype	MP:0010771	7.5	TRIM21, SRC, COL1A1, COL1A2, PRL, HOXD13
12	muscle phenotype	MP:0005369	7.3	COL1A1, COL1A2, EDN1, EDNRA, HOXD13, HSPG2
13	immune system phenotype	MP:0005387	6.9	PDE4A, COL1A1, SRC, TRIM21, GIT2, HSPG2
14	tumorigenesis	MP:0002006	6.8	PRL, TGFBI, TGFB1, ACE, COL1A1, SMAD3
15	normal phenotype	MP:0002873	6.8	IFNG, GIT2, CTGF, COL1A1, COL1A2, EDNRA
16	reproductive system phenotype	MP:0005389	6.6	PRL, TGFB1, SMAD3, SRC, IFNG, FBN1
17	nervous system phenotype	MP:0003631	6.4	SMAD3, COL1A1, EDN1, EDNRA, TSKU, TGFB1
18	mortality/aging	MP:0010768	6.3	HSPG2, HOXD13, TRIM21, TPO, SMAD3, COL1A2
19	growth/size phenotype	MP:0005378	6.2	HOXD13, TPO, SRC, CTGF, SMAD3, COL1A1
20	vision/eye phenotype	MP:0005391	5.4	HSPG2, HOXD13, SRC, CTGF, SMAD3, COL1A1
21	homeostasis/metabolism phenotype	MP:0005376	5.2	COL1A1, CRP, SMAD3, CTGF, TPO, EDN1
22	cardiovascular system phenotype	MP:0005385	5.1	CRP, SMAD3, CTGF, HSPG2, COL1A1, COL1A2
23	cellular phenotype	MP:0005384	3.2	ACE, COL1A2, COL1A1, SMAD3, CTGF, SRC

Articles related to systemic scleroderma:

(show all 19)

id	Title	Authors	Year	Affiliating Genes
1	Antibodies to enzymes of purine metabolism as a fact or of gastrointestinal tract lesions in systemic scleroderma (19551958)	Shilova L.N.... Moskvitina O.V.	2009	ADA
2	Surgical result of critical limb ischemia due to tibi al arterial occlusion in patients with systemic scleroderma. (19223137)	Deguchi J.... Miyata T.	2009	APOH
3	Platelet activation in patients with systemic scleroderma--pattern and significance. (18333373)	Agache I.... Duca L.	2007	SELP, TPO, CD40LG
4	Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: important pathogenetic steps in early and late stage of systemic scleroderma? (16139999)	Brinckmann J.... Hunzelmann N.	2005	IL4, PLOD2
5	Effects of acute pharmacological blockade of the ren in-angiotensin system on intrarenal hemodynamics in patients with systemic lupu s erythematosus and systemic scleroderma (11521515)	Bugrova O.V.... Gromova M.M.	2001	ACE
6	Surfactant protein D (SP-D) and systemic scleroderma (SSc). (11603386)	Maeda M.... Kitajima Y.	2001	SFTPD, HOXD13
7	Double-blind, placebo-controlled study of oral calcitriol for the treatment of localized and systemic scleroderma. (11100017)	Hulshof M.M.... Dijkmans B.A.	2000	IFNG
8	Expression of TGF-beta 1, -beta 2 and -beta 3 in localized and systemic scleroderma. (10468187)	Querfeld C.... Sollberg S.	1999	TGFB1
9	Increased cutaneous immunoreactive stem cell factor expression and serum stem cell factor level in systemic scleroderma. (10342750)	Kihira C.... Shimizu M.	1998	KITLG
10	The correlation between salivary endothelial expression of E-selectin and clinical and biological parameters in systemic scleroderma (9775068)	Hebbar M.... Devulder B.	1998	SELE
11	Is there circadian variation of plasma endothelin (ET-1) in patients with systemic scleroderma (SSc)? (9438906)	Maeda M.... Kitajima Y.	1997	EDN1
12	Effects of cytokine application on glucocorticoid secretion in an animal model for systemic scleroderma. (8155253)	Brezinschek H.P.... Wick G.	1993	MIF
13	The clinical significance of detecting the inhibition of topoisomerase I by the sera of patients with systemic scleroderma (1333647)	Shcherbakov A.B.... Guseva N.G.	1992	TOP1
14	An analysis of the hormonal response during the performance of stress tests in patients with systemic lupus erythematosus and systemic scleroderma (1333648)	Dosin I.u.M.... Iagur V.E.	1992	PRL, INS
15	HLA in systemic scleroderma (PSS) and familial scleroderma. (2050902)	Sasaki T.... Nakajima H.	1991	HSPG2
16	Hemolytic-uremic syndrome with anticardiolipin antibo dies revealing paraneoplastic systemic scleroderma. (1758545)	Meyrier A.... Rainfray M.	1991	APOH
17	Expression of intercellular adhesion molecule-1 (ICAM-1) in the skin of patients with systemic scleroderma. (1682392)	Majewski S.... Krieg T.	1991	ICAM1
18	The fibrillarin (Scl-34) autoantibody in systemic scleroderma (2178987)	Kuhn G.... Jablonska S.	1990	FBL
19	Anti-cardiolipin antibodies and other immunological disorders in patients with systemic scleroderma (2098888)	SperanskiA- A.I.... Ivanova S.M.	1990	APOH

Genes related to systemic scleroderma according to GeneCards:

(show top 50)    (show all 56)

id	Symbol	Description	Score	GeneCards Section Context
1	FBLL1	fibrillarin-like 1	11.0
2	APITD1	apoptosis-inducing, TAF9-like domain 1	11.0
3	HOXD13	homeobox D13	11.0	Publications
4	TSKU	tsukushi small leucine rich proteoglycan homolog (Xenopus laevis)	11.0
5	ZBTB7B	zinc finger and BTB domain containing 7B	11.0
6	RPP30	ribonuclease P/MRP 30kDa subunit	11.0
7	HARS	histidyl-tRNA synthetase	11.0
8	CENPB	centromere protein B, 80kDa	11.0
9	EXOSC9	exosome component 9	11.0
10	FBL	fibrillarin	11.0	Publications
11	FAM167A	family with sequence similarity 167, member A	11.0
12	CENPA	centromere protein A	11.0
13	UBTF	upstream binding transcription factor, RNA polymerase I	11.0
14	SFTPD	surfactant protein D	11.0	Publications
15	GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	11.0
16	PLOD2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	11.0	Publications
17	IRF5	interferon regulatory factor 5	11.0
18	CD19	CD19 molecule	11.0
19	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.0	Publications
20	SNRNP70	small nuclear ribonucleoprotein 70kDa (U1)	11.0
21	TRIM21	tripartite motif containing 21	11.0
22	EXOSC10	exosome component 10	11.0
23	TGFBI	transforming growth factor, beta-induced, 68kDa	11.0
24	CENPC1	centromere protein C 1	11.0
25	BLK	B lymphoid tyrosine kinase	11.0
26	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
27	COL1A2	collagen, type I, alpha 2	11.0
28	TPO	thyroid peroxidase	11.0	Publications
29	COL1A1	collagen, type I, alpha 1	11.0
30	KITLG	KIT ligand	11.0	Publications
31	ADA	adenosine deaminase	11.0	Publications
32	BANK1	B-cell scaffold protein with ankyrin repeats 1	11.0
33	CTGF	connective tissue growth factor	11.0
34	STAT4	signal transducer and activator of transcription 4	11.0
35	EDNRA	endothelin receptor type A	11.0
36	PDE4A	phosphodiesterase 4A, cAMP-specific	11.0
37	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
38	SELE	selectin E	11.0	Publications
39	SMAD3	SMAD family member 3	11.0
40	TOP1	topoisomerase (DNA) I	11.0	Publications
41	CD40LG	CD40 ligand	11.0	Publications
42	FBN1	fibrillin 1	11.0
43	EDN1	endothelin 1	11.0	Publications
44	HSPG2	heparan sulfate proteoglycan 2	11.0	Publications
45	ICAM1	intercellular adhesion molecule 1	11.0	Publications
46	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0
47	VEGFA	vascular endothelial growth factor A	11.0
48	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
49	PRL	prolactin	11.0	Publications
50	CRP	C-reactive protein, pentraxin-related	11.0	Publications

Pathways related to systemic scleroderma according to GeneDecks:

(show all 34)

id	Pathway	Score	Top Affiliating Genes
1	PTEN Pathway36	9.8	COL1A2, COL1A1, CTGF, HSPG2, FBN1, KITLG
2	Lymphocyte Signaling3	9.7	IRF5, CD19, BLK, KITLG
3	ILK Signaling36	9.6	COL1A2, COL1A1, CTGF, HSPG2, FBN1, KITLG
4	Inhibition of Angiogenesis by TSP136	9.5	TGFB1, COL1A2, COL1A1, HSPG2, FBN1
5	Development_Endothelin-1/EDNRA transactivation of EGFR41	9.5	EDNRA, EDN1, COL1A2, COL1A1, SRC
6	Development Endothelin-1/EDNRA transactivation of EGFR10	9.5	EDNRA, EDN1, COL1A2, COL1A1, SRC
7	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.5	COL1A1, SMAD3, IFNG, IL6
8	Amoebiasis20	9.4	TGFB1, COL1A2, COL1A1, IL6
9	African trypanosomiasis20	9.4	ICAM1, IFNG, IL6, SELE
10	Immune response_MIF-mediated glucocorticoid regulation41	9.3	ICAM1, IFNG, IL6, MIF, MMP1
11	Immune response MIF-mediated glucocorticoid regulation10	9.3	ICAM1, IFNG, IL6, MIF, MMP1
12	Th17 Differentiation37	9.2	STAT4, TGFB1, SMAD3, IL6
13	Development_VEGF signaling and activation41	9.2	SRC, ICAM1, VEGFA, SELE
14	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.1	COL1A1, SMAD3, IFNG, IL6
15	Development VEGF signaling and activation10	9.1	SRC, ICAM1, VEGFA, SELE
16	Hematopoietic cell lineage20	9.1	TPO, IL6, IL4, CD19, KITLG
17	UPA-UPAR Pathway36	9.0	STAT4, COL1A2, COL1A1, SRC, HSPG2, FBN1
18	Molecular Mechanisms of Cancer36	9.0	TGFB1, COL1A1, CTGF, FBN1, IL6, KITLG
19	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.9	IL4, IL6, TGFB1
20	Chagas disease (American trypanosomiasis)20	8.8	IL6, IFNG, SMAD3, ACE, TGFB1
21	Intestinal immune network for IgA production20	8.6	TGFB1, IL6, IL4, CD40LG
22	Malaria20	8.6	SELE, TGFB1, ICAM1, IFNG, IL6, CD40LG
23	Rheumatoid arthritis20	8.6	TGFB1, ICAM1, IFNG, IL6, MMP1, VEGFA
24	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.6	TGFB1, IFNG, IL6, IL4
25	Selected targets of GCR-alpha10	8.5	KITLG, INS, IL4, IL6
26	Rho Family GTPases36	8.4	TGFB1, COL1A2, COL1A1, CTGF, HSPG2, FBN1
27	Pancreatic Adenocarcinoma36	8.4	STAT4, TGFB1, CTGF, SRC, IL6, MMP1
28	Jak-STAT signaling pathway20	8.4	PRL, STAT4, TPO, IFNG, IL6, IL4
29	Phospholipase-C Pathway36	8.2	TGFB1, COL1A2, COL1A1, CTGF, SRC, HSPG2
30	p70S6K Signaling36	8.1	TGFB1, CTGF, IL6, IL4, INS, CD19
31	MAPK Signaling36	8.0	STAT4, TGFB1, COL1A2, COL1A1, CTGF, SRC
32	JAK-STAT Pathway36	7.8	PRL, STAT4, TGFB1, CTGF, IFNG, IL6
33	Cytokine-cytokine receptor interaction20	7.5	PRL, TGFB1, TPO, IFNG, IL6, IL4
34	ERK Signaling36	7.3	TGFB1, COL1A2, COL1A1, CTGF, SRC, HSPG2

Compounds related to systemic scleroderma according to GeneDecks:

(show top 50)    (show all 184)

id	Compound	Score	Top Affiliating Genes
1	polyethylene glycol32	10.5	SELE, KITLG
2	budesonide32 42 9 9	13.4	SFTPD, KITLG, PDE4A
3	endotoxin32	10.0	CRP, SFTPD, APOH, MIF, EDNRA
4	pge232	9.6	PDE4A, SELE, MMP1, HSPG2, EDN1, EDNRA
5	pravastatin32 34 9 18 9	13.3	SELE, CRP, CTGF, IL6, SELP
6	n acetylcysteine32	9.2	SELE, SMAD3, CTGF, SRC, MMP1, SELP
7	quinapril32 9 9	11.2	EDN1, ACE, CRP, SELP, SELE
8	epinephrine32 9 18 9	12.1	SELP, INS, PDE4A, KITLG, SELE, MMP1
9	iloprost32 42 9 9	11.9	EDN1, EDNRA, PDE4A, SELE, SELP, HSPG2
10	rapamycin32 42	9.6	CTGF, IFNG, SRC, VEGFA, UBTF, KITLG
11	8-isoprostane32	8.5	IL6, EDN1, CRP, SELE, ICAM1, INS
12	estrogen32	8.5	COL1A2, APOH, FBN1, INS, MIF, PRL
13	fenofibrate32 9 9	10.4	SELE, CRP, ICAM1, IL6, INS, CD40LG
14	ang ii32	8.3	HSPG2, VEGFA, SRC, CTGF, EDN1, ACE
15	losartan32 34 9 9	11.3	HSPG2, SELP, SELE, EDN1, MMP1, CTGF
16	atorvastatin32 34 9 18 9	12.2	IL6, MMP1, VEGFA, SELP, SELE, ICAM1
17	arginine32	8.1	ADA, PRL, TGFBI, FBN1, APOH, TPO
18	prostacyclin32	8.1	ACE, SELP, SELE, APOH, PDE4A, EDN1
19	okt332	8.0	IL6, ICAM1, SELE, CD40LG, IL4, IFNG
20	pentoxifylline32 9 9	10.0	ICAM1, PDE4A, SELP, IFNG, IL6, IL4
21	gm-csf32	7.9	TGFB1, IFNG, IL6, IL4, KITLG, ICAM1
22	infliximab32 9 9	9.8	IFNG, VEGFA, APOH, IL6, SELE, IL4
23	doxorubicin32 34 9 9	10.8	MIF, VEGFA, SELE, KITLG, TGFB1, CD40LG
24	neopterin32	7.7	ADA, CD40LG, IL4, IL6, IFNG, ICAM1
25	sb 20358032 42	8.6	EDN1, SMAD3, IFNG, IL6, MMP1, VEGFA
26	histamine32 18	8.5	HSPG2, SRC, EDN1, ADA, ICAM1, IL4
27	cyclosporin a32 42	8.5	TGFB1, SELP, EDN1, SRC, ICAM1, IL4
28	hydrocortisone32 9 9	9.5	KITLG, PRL, TPO, IFNG, IL4, IL6
29	aspirin32 34 18	9.4	SELE, KITLG, PDE4A, TGFB1, CRP, SELP
30	phosphatidylinositol32	7.3	STAT4, EDNRA, EDN1, SFTPD, SMAD3, KITLG
31	nitric oxide32 9 18 9	10.3	KITLG, PDE4A, ACE, EDNRA, EDN1, CTGF
32	pd 98,05932	7.2	SMAD3, EDN1, CTGF, SRC, HSPG2, ICAM1
33	rantes32	7.2	TGFB1, IFNG, IL6, IL4, MIF, CD40LG
34	thymidine32 18	8.1	IL4, CTGF, IFNG, IL6, SFTPD, MIF
35	lactate32	7.1	TGFB1, CRP, CTGF, ICAM1, APOH, CD40LG
36	simvastatin32 34 42 9 18 9	12.0	SELE, COL1A2, IL6, IFNG, ICAM1, HSPG2
37	genistein32 9 18 9	10.0	SRC, SELP, IFNG, MMP1, CD40LG, VEGFA
38	ly29400232	6.9	SRC, ICAM1, IL6, IL4, VEGFA, SELE
39	herbimycin a32 42	7.8	MIF, MMP1, SELE, KITLG, IL6, IL4
40	actinomycin d32	6.7	FBL, TOP1, IFNG, ICAM1, TGFB1, EDN1
41	vegf32	6.7	MIF, COL1A1, CRP, SMAD3, CTGF, SRC
42	creatinine32	6.6	ADA, APOH, SELE, MMP1, CD40LG, SELP
43	retinoic acid32 42 18	8.5	FBN1, IFNG, ICAM1, HSPG2, TPO, COL1A1
44	indomethacin32 9 9	8.5	IFNG, TGFB1, EDNRA, EDN1, SRC, HSPG2
45	alanine32	6.3	SRC, KITLG, MIF, SELE, CD40LG, ADA
46	norepinephrine32 9 18 9	9.3	PDE4A, UBTF, SELP, SELE, KITLG, CD40LG
47	serine32	6.2	TGFBI, COL1A1, COL1A2, TGFB1, STAT4, EDNRA
48	cycloheximide32	5.7	SELE, TOP1, EDN1, CRP, SMAD3, CTGF
49	tyrosine32	5.2	BLK, KITLG, PDE4A, COL1A2, MIF, EDNRA
50	dexamethasone32 42 34 9 9	8.4	CD40LG, SFTPD, KITLG, PDE4A, SELP, VEGFA

Cellular components related to systemic scleroderma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	collagen type I	GO:005584	10.2	COL1A1, COL1A2
2	extracellular matrix	GO:031012	9.4	TGFBI, COL1A2, COL1A1, HSPG2, APOH, FBN1
3	proteinaceous extracellular matrix	GO:005578	8.6	TGFBI, TGFB1, CTGF, FBN1, MMP1, VEGFA
4	external side of plasma membrane	GO:009897	8.0	ADA, ACE, ICAM1, IFNG, IL4, CD19
5	extracellular region	GO:005576	5.7	CRP, COL1A1, COL1A2, EDN1, TSKU, TGFB1
6	extracellular space	GO:005615	4.1	KITLG, HSPG2, CTGF, CRP, COL1A1, COL1A2

Biological processes related to systemic scleroderma according to GeneDecks:

(show all 23)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of leukocyte migration	GO:002687	10.4	SELP, SELE
2	nuclear polyadenylation-dependent rRNA catabolic process	GO:071035	10.4	EXOSC9, EXOSC10
3	histamine secretion	GO:001821	10.3	ADA, EDNRA, EDN1
4	positive regulation of odontogenesis	GO:042482	9.9	EDN1, EDNRA, TGFB1
5	leukocyte cell-cell adhesion	GO:007159	9.9	ICAM1, CD40LG, SELP, SELE
6	evasion or tolerance of host defenses by virus	GO:019049	9.7	TGFB1, SMAD3
7	mononuclear cell proliferation	GO:032943	9.7	TGFB1, ACE
8	positive regulation of epithelial to mesenchymal transition	GO:010718	9.7	SMAD3, COL1A1, TGFB1
9	positive regulation of MAP kinase activity	GO:043406	9.6	KITLG, VEGFA, EDN1, TGFB1
10	positive regulation of B cell proliferation	GO:030890	9.4	ADA, IL4, MIF, CD40LG
11	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	INS, IFNG, ICAM1, EDN1
12	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.3	TGFB1, IL6, MIF, VEGFA
13	positive regulation of MHC class II biosynthetic process	GO:045348	9.3	CD40LG, IL4, IFNG
14	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.2	IL6, INS, MIF, VEGFA, KITLG
15	leukocyte migration	GO:050900	9.2	COL1A2, COL1A1, SRC, ICAM1, MMP1, SELP
16	regulation of immune response	GO:050776	9.0	SMAD3, ICAM1, IL4, CD19, CD40LG
17	positive regulation of cell migration	GO:030335	8.9	TGFB1, EDN1, COL1A1, SMAD3, INS, VEGFA
18	response to hypoxia	GO:001666	8.8	VEGFA, ADA, TGFB1, EDNRA, EDN1, PLOD2
19	inflammatory response	GO:006954	8.5	TGFB1, SELE, SELP, CD40LG, MIF, IL6
20	platelet activation	GO:030168	8.2	TGFB1, COL1A2, COL1A1, SRC, IL6, CD40LG
21	negative regulation of apoptotic process	GO:043066	8.1	EDNRA, SMAD3, IL6, IL4, INS, MIF
22	response to drug	GO:042493	8.0	IL4, IFNG, ICAM1, EDN1, TOP1, TGFB1
23	positive regulation of cell proliferation	GO:008284	7.8	TGFB1, EDNRA, EDN1, CTGF, IL6, INS

Molecular functions related to systemic scleroderma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	oligosaccharide binding	GO:070492	10.1	SELE, SELP
2	cell surface binding	GO:043498	9.5	VEGFA, MIF, ICAM1
3	growth factor activity	GO:008083	8.0	TGFB1, CTGF, IL6, IL4, VEGFA, KITLG
4	cytokine activity	GO:005125	7.7	EDN1, IFNG, IL6, IL4, MIF, CD40LG
5	protein binding	GO:005515	3.7	ADA, HSPG2, EXOSC10, GIT2, TRIM21, SRC