MCID: SYS003
MIFTS: 51

Systolic Heart Failure malady

Summaries for Systolic Heart Failure

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MalaCards: Systolic Heart Failure, also known as heart failure, systolic, is related to hypertension and coronary artery disease. An important gene associated with Systolic Heart Failure is NPPB (natriuretic peptide B), and among its related pathways are Renin-angiotensin system and MicroRNAs in cardiomyocyte hypertrophy. The compounds hydralazine and captopril have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and testes, and related mouse phenotypes are renal/urinary system and muscle.

Aliases & Classifications for Systolic Heart Failure

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8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

systolic heart failure 8 10
heart failure, systolic 60


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Disease Ontology8 DOID:9651
ICD9CM27 428.20, 428.2
SNOMED-CT56 417996009
MeSH34 D054143

Related Diseases for Systolic Heart Failure

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17GeneCards, 18GeneDecks
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Diseases related to Systolic Heart Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.9CST3, NPPB, NPPA, EDN1, NR3C2, AGT
2coronary artery disease30.8NPPB, ACE, CST3, AGT, ADIPOQ, NOS3
3chronic kidney failure30.8ADIPOQ, ACE, NOS3, CYP11B2, AGT, NR3C2
4obesity30.7ADIPOQ, NOS3, AGT, NR3C2, UCN2, UCN
5chagas disease30.6NPPB
6congestive heart failure30.5SHF
7myocardial infarction30.5NR3C2, AGT, CYP11B2, ADIPOQ, ACE, NOS3
8central sleep apnea30.4NPPB
9hypothyroidism30.4CST3
10hypertensive heart disease30.4ACE, NR3C2, NPPB, NPPA
11ischemic heart disease30.4ACE, NPPA, EDN1, AGT, NPPB, NOS3
12acute myocardial infarction30.4ACE, AGT, NR3C2, EDN1, NPPA, NPPB
13diabetes mellitus30.4EDN1, PDK4, CST3, NPPB, NPPA, NR3C2
14type 2 diabetes mellitus30.1NOS3, ACE, ADIPOQ, PDK4, CST3, AGT
15ischemia30.1EDN1, NOS3, UCN, CST3, NPPB, AGT
16diastolic heart failure10.9
17kidney disease10.6
18sleep disorder10.4
19chronic pulmonary heart disease10.3
20angina pectoris10.1
21right bundle branch block10.1
22cerebritis10.1
23intermittent claudication10.1
24end stage renal failure10.1
25hypertrophic cardiomyopathy10.1
26night blindness10.1
27myocarditis10.0NPPB
28pulmonary embolism10.0NPPB
29kawasaki disease10.0NPPB
30gastritis10.0UCN
31galactosemia10.0CYP2D6
32glaucoma10.0EDN1
33migraine10.0CYP2D6
34gingivitis10.0CST3
35rhinitis10.0CMA1
36hepatitis c10.0CYP2D6
37hypoaldosteronism10.0CYP11B2
38eating disorder10.0NPPB
39glomerulonephritis10.0MPO
40cystic fibrosis10.0MPO
41inflammatory bowel disease10.0MPO
42oligohydramnios10.0ACE
43panic disorder10.0UCN
44hepatitis10.0CYP2D6
45anuria10.0ACE
46pneumonia10.0MPO
47vasculitis10.0MPO
48cushing's syndrome10.0CYP11B2
49deficiency anemia10.0ACE
50pancreatitis10.0MPO

Graphical network of the top 20 diseases related to Systolic Heart Failure:



Diseases related to systolic heart failure

Clinical Features for Systolic Heart Failure

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Drugs & Therapeutics for Systolic Heart Failure

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Systolic Heart Failure

Drug clinical trials:

Search ClinicalTrials for Systolic Heart Failure

Search NIH Clinical Center for Systolic Heart Failure

Search CenterWatch for Systolic Heart Failure

Genetic Tests for Systolic Heart Failure

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Anatomical Context for Systolic Heart Failure

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32MalaCards
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MalaCards organs/tissues related to Systolic Heart Failure:

32
Heart, Brain, Testes, Kidney, Bone, Endothelial, Skeletal muscle, Monocytes, T cells

Animal Models for Systolic Heart Failure or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Systolic Heart Failure:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.9EDN1, NR3C2, AGT, CYP11B2, ACE, ADIPOQ
2MP:00053697.8ADIPOQ, CORIN, CST3, NPPB, NPPA, EDN1
3MP:00053857.5EDN1, NPPA, NPPB, CST3, CORIN, MPO
4MP:00053766.3NPPA, CST3, PDK4, UCN2, UCN, CORIN

Publications for Systolic Heart Failure

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50PubMed
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Articles related to Systolic Heart Failure:

(show top 50)    (show all 627)
idTitleAuthorsYear
1
The evaluation of the clinical utility of urocortin 1 in systolic heart failure. (24408067)
2014
2
Early NT-proBNP Decrease With Ivabradine in Ambulatory Patients With Systolic Heart Failure. (23929789)
2013
3
The inpatient experience and predictors of length of stay for patients hospitalized with systolic heart failure: comparison by commercial, Medicaid, and Medicare payer type. (22954063)
2013
4
Is chronic sildenafil therapy safe and clinically beneficial in patients with systolic heart failure? (23241003)
2013
5
Prolonged mean VO2 response time in systolic heart failure: an indicator of impaired right ventricular-pulmonary vascular function. (23572493)
2013
6
Value of proBNP1-108 testing for the risk stratification of patients with systolic heart failure. (24140405)
2013
7
Serum uric acid levels correlate with atrial fibrillation in patients with chronic systolic heart failure. (22800888)
2012
8
Decreased free sphingoid base concentration in the plasma of patients with chronic systolic heart failure. (22296975)
2012
9
Functional and hemodynamic cardiac determinants of exercise capacity in patients with systolic heart failure. (22818784)
2012
10
The product of eGFR and hemoglobin may help predict mortality in systolic heart failure patients without severe anemia and renal failure. (22395368)
2012
11
Mode of action and effects of standardized collaborative disease management on mortality and morbidity in patients with systolic heart failure: the Interdisciplinary Network for Heart Failure (INH) study. (21956192)
2012
12
Long-term statin therapy in patients with systolic heart failure and normal cholesterol: effects on elevated serum markers of collagen turnover, inflammation, and B-type natriuretic peptide. (22154198)
2012
13
Echocardiographic evaluation of hemodynamics in patients with decompensated systolic heart failure. (21398512)
2011
14
Open access to an outpatient intravenous diuresis program in a systolic heart failure disease management program. (22103923)
2011
15
The cardiorenal anaemia syndrome in systolic heart failure: prevalence, clinical correlates, and long-term survival. (20858705)
2011
16
Serum uric acid levels correlate with filling pressures in systolic heart failure. (21449996)
2011
17
Impact of descent and stay at a Dead Sea resort (low altitude) on patients with systolic congestive heart failure and an implantable cardioverter defibrillator. (21838181)
2011
18
Cystatin C levels are associated with the prognosis of systolic heart failure patients. (22117908)
2011
19
Drug treatment for chronic systolic heart failure. (20101534)
2010
20
Circulating matrix metalloproteinase-3 and metalloproteinase-9 and tissue Doppler measures of diastolic dysfunction to risk stratify patients with systolic heart failure. (20211331)
2010
21
Evidence-based medication adherence in Hispanic patients with systolic heart failure in a disease management program. (20662871)
2010
22
Determinants of physical fitness in males with systolic heart failure. (20301023)
2010
23
Clinical practice. Systolic heart failure. (20089973)
2010
24
Effects of L-arginine on the Minnesota Living with Heart Failure Questionnaire quality-of-life score in patients with chronic systolic heart failure. (19946230)
2009
25
Diastolic and systolic heart failure: different stages or distinct phenotypes of the heart failure syndrome? (19948097)
2009
26
Relationship between thoracic fluid content and natriuretic peptide type B in patients with systolic heart failure. (20024849)
2009
27
Chronic systemic inflammation accompanies impaired ventricular diastolic function, detected by Doppler imaging, in patients with newly diagnosed systolic heart failure (Hellenic Heart Failure Study). (19165564)
2009
28
Usefulness of C-reactive protein and left ventricular diastolic performance for prognosis in patients with left ventricular systolic heart failure. (18237602)
2008
29
Relation of systolic blood pressure to survival in both ischemic and nonischemic systolic heart failure. (19064027)
2008
30
Systolic heart failure: chronic and acute syndromes. (18158477)
2008
31
CORONA study highlights challenges of treating older patients with systolic heart failure. (18092121)
2007
32
Contribution of right-sided heart enlargement to cardiomegaly on chest roentgenogram in diastolic and systolic heart failure. (17196464)
2007
33
Inducible nitric oxide synthase deficiency protects the heart from systolic overload-induced ventricular hypertrophy and congestive heart failure. (17363700)
2007
34
Systolic and diastolic ventricular dyssynchrony in systolic and diastolic heart failure. (17207729)
2007
35
Prognosis of hospitalized new-onset systolic heart failure in Indo-Asians--a lethal problem. (18068620)
2007
36
Brief report: beta-blocker use among veterans with systolic heart failure. (17105526)
2006
37
Angiotensin-converting-enzyme inhibitors in stable vascular disease without left ventricular systolic dysfunction or heart failure: a combined analysis of three trials. (16905022)
2006
38
Total cholesterol levels and mortality risk in nonischemic systolic heart failure. (17161056)
2006
39
Increased productivity of tumor necrosis factor-alpha in helper T cells in patients with systolic heart failure. (16271779)
2006
40
Angiotensin-converting enzyme inhibitor use in elderly patients hospitalized with heart failure and left ventricular systolic dysfunction. (15528896)
2005
41
Ventriculovascular coupling in systolic and diastolic heart failure. (16332314)
2005
42
Analysis of left ventricular systolic function using midwall mechanics in patients >60 years of age with hypertensive heart disease and heart failure. (16253602)
2005
43
Valsartan: a review of its use in patients with heart failure and/or left ventricular systolic dysfunction after myocardial infarction. (15554725)
2004
44
Mitral regurgitation in patients with advanced systolic heart failure. (15309693)
2004
45
Angiotensin-converting enzyme inhibitors, beta-blockers, and mortality in systolic heart failure. (15063454)
2004
46
Remodeling in systolic heart failure: therapeutic implications. (15377130)
2004
47
Prevalence and severity of mitral regurgitation in chronic systolic heart failure. (12565101)
2003
48
Effect of losartan on circulating TNFalpha levels and left ventricular systolic performance in patients with heart failure. (11702033)
2001
49
Doppler evaluation of systolic and diastolic heart failure in patients with cardiomyopathy. (11433812)
2001
50
Exophthalmos, stare, increase in intraocular pressure and systolic propulsion of the eyeballs due to congestive heart failure. (5474495)
1970

Genetic Variations for Systolic Heart Failure

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Expression for genes affiliated with Systolic Heart Failure

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Systolic Heart Failure

Search GEO for disease gene expression data for Systolic Heart Failure.

Pathways for genes affiliated with Systolic Heart Failure

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29KEGG, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems, 49PharmGKB
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Compounds for genes affiliated with Systolic Heart Failure

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Systolic Heart Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 195)
idCompoundScoreTop Affiliating Genes
1hydralazine44 49 1112.5CYP11B2
2captopril44 28 49 59 1114.0CST3, EDN1, NR3C2, MMP2
3bisoprolol44 49 1112.0NPPA, ACE, CYP2D6, NPPB
4trandolapril44 1111.0NPPB, EDN1, ACE, NPPA
5nebivolol44 1111.0CYP2D6, EDN1, ACE, NOS3
6hanp449.9NPPA, ADIPOQ, NPPB, EDN1
7chymostatin449.9CMA1, ACE, EDN1, AGT
8alacepril449.9NPPA, ACE, NPPB
9isosorbide dinitrate44 49 1111.9NPPA, EDN1, NOS3, ACE
10lisinopril44 11 2411.9ACE, NPPB, NPPA, AGT
11enalaprilat449.8NPPB, AGT, EDN1, NPPA, ACE
12ramipril44 1110.8CST3, NPPB, NPPA, ADIPOQ, ACE
13norepinephrine44 11 2411.8UCN, NR3C2, CYP11B2, UCN2
14valsartan44 59 28 1112.8EDN1, ADIPOQ, ACE, AGT, NPPB
15spironolactone49 44 59 28 1113.8NPPB, CYP11B2, NPPA, ACE, NR3C2
16perindopril44 49 1111.8NPPB, NPPA, AGT, NOS3, ACE
17diltiazem44 28 1111.8AGT, EDN1, ACE, MMP2, CYP2D6
18irbesartan44 28 49 1112.7AGT, CYP11B2, ADIPOQ, CYP2D6, ACE
19telmisartan44 28 1111.7ADIPOQ, ACE, AGT, NPPB
20nitroglycerin44 1110.7EDN1, NPPB, NPPA, ACE, NOS3
21atenolol44 28 49 11 2413.7NPPB, CYP11B2, MMP2, AGT, ACE, CYP2D6
22n(g)-nitro-l-arginine methyl ester449.6EDN1, MMP2, AGT, NOS3
23carvedilol44 49 28 1112.6NOS3, ACE, EDN1, NPPA, NPPB, CYP2D6
24sildenafil44 49 28 11 2413.6NOS3, CYP2D6, NPPB, EDN1, NPPA, ACE
25l-nmma449.6NPPA, NPPB, EDN1, NOS3, AGT
26enalapril44 49 1111.6NPPB, NPPA, EDN1, AGT, ADIPOQ, ACE
27metoprolol44 28 49 11 2413.5CYP2D6, NOS3, NPPB, NPPA, ADIPOQ, ACE
28haloperidol44 28 2 49 1113.5AGT, CYP2D6, NR3C2, NPPA, NPPB, CYP11B2
29phenylephrine44 28 11 2412.5NOS3, EDN1, NPPA, AGT, NPPB, MMP2
308-isoprostane449.5ADIPOQ, NOS3, NPPB, MMP2, MPO, EDN1
31candesartan44 28 1111.5ADIPOQ, MMP2, AGT, NPPB, ACE, NOS3
32sodium44 2410.5ACE, AGT, NR3C2, EDN1, NPPB, CYP11B2
33felodipine44 28 1111.4NR3C2, CYP2D6, ACE, NPPA
34amlodipine44 49 11 2412.3NOS3, NPPA, AGT, ADIPOQ, NPPB, CYP2D6
35potassium44 11 2411.3NR3C2, UCN, CYP11B2, ACE, AGT
36nifedipine44 49 28 1112.3AGT, CYP11B2, EDN1, ADIPOQ, ACE, NPPA
37atorvastatin44 49 28 11 2413.3AGT, EDN1, NPPB, CYP2D6, MMP2, ADIPOQ
38dopamine44 28 11 2412.2CYP2D6, UCN, NPPB, NR3C2, AGT, UCN2
39ng-nitro-l-arginine449.2NPPA, EDN1, AGT, NOS3
40prostacyclin449.2AGT, EDN1, NOS3, ACE, ADIPOQ, NPPA
41dexamethasone44 49 28 1112.2NPPB, PDK4, NR3C2, AGT, CYP11B2, ADIPOQ
42ang ii449.2ACE, NPPA, EDN1, NOS3, CYP11B2, AGT
43losartan44 49 28 1112.1NR3C2, CYP11B2, ADIPOQ, ACE, AGT, EDN1
44acth448.9CYP11B2, UCN, UCN2, NPPA, NR3C2, AGT
45glucose448.7UCN, UCN2, PDK4, CST3, NR3C2, AGT
46creatinine448.6CST3, NPPB, AGT, MMP2, NPPA, EDN1
47arginine448.5ADIPOQ, NPPB, CST3, UCN, NOS3, CYP11B2
48acetylcholine44 49 28 11 2412.5CYP2D6, MPO, NOS3, ACE, ADIPOQ, AGT
49nitric oxide44 11 2410.1UCN2, NPPB, NPPA, EDN1, MPO, NR3C2
50calcium44 49 11 2410.9NPPA, UCN, NOS3, CMA1, MMP2, CYP11B2

GO Terms for genes affiliated with Systolic Heart Failure

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16Gene Ontology
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Cellular components related to Systolic Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1CST3, NPPB, NPPA, EDN1, MPO, AGT
2extracellular regionGO:0055767.4ADIPOQ, CORIN, UCN, UCN2, CST3, NPPB

Biological processes related to Systolic Heart Failure according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1regulation of renal sodium excretionGO:03581310.3AGT, CORIN
2regulation of renal output by angiotensinGO:00201910.3ACE, AGT
3cGMP biosynthetic processGO:00618210.3NPPA, NPPB
4artery smooth muscle contractionGO:01482410.3AGT, EDN1
5regulation of systemic arterial blood pressure by endothelinGO:00310010.3EDN1, NOS3
6body fluid secretionGO:00758910.3NPPB, EDN1
7regulation of vasodilationGO:04231210.2NPPB, ACE
8positive regulation of cardiac muscle hypertrophyGO:01061310.2EDN1, AGT
9angiotensin maturationGO:00200310.2ACE, CMA1, AGT
10positive regulation of renal sodium excretionGO:03581510.2NPPB, EDN1, AGT
11regulation of vasoconstrictionGO:01922910.2ACE, AGT, EDN1
12regulation of blood vessel sizeGO:05088010.1NPPB, NPPA, NOS3
13positive regulation of urine volumeGO:03581010.1EDN1, NPPB
14low-density lipoprotein particle remodelingGO:03437410.1MPO, AGT
15blood vessel remodelingGO:00197410.1ACE, NOS3, AGT
16negative regulation of hormone secretionGO:04688810.0UCN, EDN1, ADIPOQ
17receptor guanylyl cyclase signaling pathwayGO:00716810.0NPPB, NPPA
18female pregnancyGO:0075659.9NPPA, UCN, CORIN
19negative regulation of blood pressureGO:0457769.9UCN, NOS3, ADIPOQ
20regulation of blood pressureGO:0082179.8ACE, NOS3, NPPA, NPPB, CORIN
21regulation of glucose metabolic processGO:0109069.8PDK4, ADIPOQ
22proteolysisGO:0065089.7CORIN, MMP2, CMA1, ACE, ACY1
23positive regulation of cellular protein metabolic processGO:0322709.6ADIPOQ, AGT

Molecular functions related to Systolic Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:0200379.5MPO, CYP2D6, CYP11B2, NOS3
2corticotropin-releasing hormone receptor 2 bindingGO:0514319.5UCN2, UCN
3receptor bindingGO:0051029.4ADIPOQ, NPPA, NPPB, UCN2
4hormone activityGO:0051799.0ADIPOQ, AGT, EDN1, NPPA, NPPB, UCN2

Products for genes affiliated with Systolic Heart Failure

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Sources for Systolic Heart Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet