MCID: SYS003
MIFTS: 51

Systolic Heart Failure malady

Summaries for Systolic Heart Failure

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MalaCards: Systolic Heart Failure, also known as heart failure, systolic, is related to hypertension and coronary artery disease. An important gene associated with Systolic Heart Failure is NPPB (natriuretic peptide B), and among its related pathways are Renin-angiotensin system and MicroRNAs in cardiomyocyte hypertrophy. The compounds hydralazine and captopril have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and testes, and related mouse phenotypes are renal/urinary system and muscle.

Aliases & Classifications for Systolic Heart Failure

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8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

systolic heart failure 8 10
heart failure, systolic 60


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Disease Ontology8 DOID:9651
ICD9CM27 428.20, 428.2
SNOMED-CT56 417996009
MeSH34 D054143

Related Diseases for Systolic Heart Failure

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17GeneCards, 18GeneDecks
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Diseases related to Systolic Heart Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.9CST3, NPPB, NPPA, EDN1, NR3C2, AGT
2coronary artery disease30.8NPPB, ACE, CST3, AGT, ADIPOQ, NOS3
3chronic kidney failure30.8ADIPOQ, ACE, NOS3, CYP11B2, AGT, NR3C2
4obesity30.7ADIPOQ, NOS3, AGT, NR3C2, UCN2, UCN
5chagas disease30.6NPPB
6congestive heart failure30.5SHF
7myocardial infarction30.5NR3C2, AGT, CYP11B2, ADIPOQ, ACE, NOS3
8central sleep apnea30.4NPPB
9hypothyroidism30.4CST3
10hypertensive heart disease30.4ACE, NR3C2, NPPB, NPPA
11ischemic heart disease30.4ACE, NPPA, EDN1, AGT, NPPB, NOS3
12acute myocardial infarction30.4ACE, AGT, NR3C2, EDN1, NPPA, NPPB
13diabetes mellitus30.4EDN1, PDK4, CST3, NPPB, NPPA, NR3C2
14type 2 diabetes mellitus30.1NOS3, ACE, ADIPOQ, PDK4, CST3, AGT
15ischemia30.1EDN1, NOS3, UCN, CST3, NPPB, AGT
16diastolic heart failure10.9
17kidney disease10.6
18sleep disorder10.4
19chronic pulmonary heart disease10.3
20angina pectoris10.1
21right bundle branch block10.1
22cerebritis10.1
23intermittent claudication10.1
24end stage renal failure10.1
25hypertrophic cardiomyopathy10.1
26night blindness10.1
27myocarditis10.0NPPB
28pulmonary embolism10.0NPPB
29kawasaki disease10.0NPPB
30gastritis10.0UCN
31galactosemia10.0CYP2D6
32glaucoma10.0EDN1
33migraine10.0CYP2D6
34gingivitis10.0CST3
35rhinitis10.0CMA1
36hepatitis c10.0CYP2D6
37hypoaldosteronism10.0CYP11B2
38eating disorder10.0NPPB
39glomerulonephritis10.0MPO
40cystic fibrosis10.0MPO
41inflammatory bowel disease10.0MPO
42oligohydramnios10.0ACE
43panic disorder10.0UCN
44hepatitis10.0CYP2D6
45anuria10.0ACE
46pneumonia10.0MPO
47vasculitis10.0MPO
48cushing's syndrome10.0CYP11B2
49deficiency anemia10.0ACE
50pancreatitis10.0MPO

Graphical network of the top 20 diseases related to Systolic Heart Failure:



Diseases related to systolic heart failure

Clinical Features for Systolic Heart Failure

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Drugs & Therapeutics for Systolic Heart Failure

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Systolic Heart Failure

Drug clinical trials:

Search ClinicalTrials for Systolic Heart Failure

Search NIH Clinical Center for Systolic Heart Failure

Search CenterWatch for Systolic Heart Failure

Genetic Tests for Systolic Heart Failure

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Anatomical Context for Systolic Heart Failure

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32MalaCards
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MalaCards organs/tissues related to Systolic Heart Failure:

32
Heart, Brain, Testes, Kidney, Bone, Endothelial, Skeletal muscle, Monocytes, T cells

Animal Models for Systolic Heart Failure or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Systolic Heart Failure:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.9EDN1, NR3C2, AGT, CYP11B2, ACE, ADIPOQ
2MP:00053697.8ADIPOQ, CORIN, CST3, NPPB, NPPA, EDN1
3MP:00053857.5EDN1, NPPA, NPPB, CST3, CORIN, MPO
4MP:00053766.3NPPA, CST3, PDK4, UCN2, UCN, CORIN

Publications for Systolic Heart Failure

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50PubMed
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Articles related to Systolic Heart Failure:

(show top 50)    (show all 627)
idTitleAuthorsYear
1
Treatment of anemia with darbepoetin alfa in systolic heart failure. (23473338)
2013
2
Ultrafiltration in heart failure with preserved ejection fraction: comparison with systolic heart failure patients. (23735537)
2013
3
Clinical benefit of eplerenone in patients with mild symptoms of systolic heart failure already receiving optimal best practice background drug therapy: analysis of the EMPHASIS-HF study. (23625945)
2013
4
Association between bilirubin and mode of death in severe systolic heart failure. (23351460)
2013
5
Dissociation Between Blood Pressure and Heart Rate Response to Hypoxia After Bilateral Carotid Body Removal in Men with Systolic Heart Failure. (24243836)
2013
6
Conductive channels identified with contrast-enhanced MR imaging predict ventricular tachycardia in systolic heart failure. (24229767)
2013
7
The impact of eplerenone at different levels of risk in patients with systolic heart failure and mild symptoms: insight from a novel risk score for prognosis derived from the EMPHASIS-HF trial. (23864130)
2013
8
The 'Echo Heart Failure Score': an echocardiographic risk prediction score of mortality in systolic heart failure. (23512095)
2013
9
Eplerenone: a review of its use in patients with chronic systolic heart failure and mild symptoms. (23881669)
2013
10
Retraction. Low sodium versus normal sodium diets in systolic heart failure: systematic review and meta-analysis. Heart. Published Online First: 21 August 2012 doi:10.1136/heartjnl-2012-302337. (23640983)
2013
11
Low sodium versus normal sodium diets in systolic heart failure: systematic review and meta-analysis. (22914535)
2013
12
Health locus of control and the sense of self-efficacy in patients with systolic heart failure: a pilot study. (23723691)
2013
13
Cardiac contractility modulation therapy in advanced systolic heart failure. (23939481)
2013
14
Impact of left ventricular diastolic function on left atrial mechanics in systolic heart failure. (23764244)
2013
15
A "PET" area of interest: myocardial metabolism in human systolic heart failure. (23180281)
2013
16
Use of cystatin C levels in estimating renal function and prognosis in patients with chronic systolic heart failure. (22038544)
2012
17
The obesity paradox in men versus women with systolic heart failure. (22497678)
2012
18
Left ventricular systolic dyssynchrony in pediatric and adolescent patients with congestive heart failure. (22658562)
2012
19
Outcomes in younger and older adults with chronic advanced systolic heart failure: a propensity-matched study. (20947188)
2012
20
Beta1-adrenergic receptor polymorphisms associated with atrial fibrillation in systolic heart failure. (22499333)
2012
21
Is hydrotherapy an appropriate form of exercise for elderly patients with biventricular systolic heart failure? (23341846)
2012
22
Integrating plasma high-sensitivity C-reactive protein and myeloperoxidase for risk prediction in chronic systolic heart failure. (21609382)
2011
23
The role of device diagnostic algorithms in the assessment and management of patients with systolic heart failure: a review. (21559229)
2011
24
Benefit of exercise therapy for systolic heart failure in relation to disease severity and etiology-findings from the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise Training study. (22137073)
2011
25
Diminished antioxidant activity of high-density lipoprotein-associated proteins in systolic heart failure. (21062973)
2011
26
Impact of left ventricular remodeling on diagnostic and prognostic value of tissue Doppler indices in chronic systolic heart failure. (21300302)
2011
27
Eplerenone in patients with systolic heart failure and mild symptoms. (21073363)
2011
28
ACEi/ARB for systolic heart failure: closing the quality gap with a sustainable intervention at an academic medical center. (20652962)
2011
29
Rationale and design of a randomized, double-blind, placebo-controlled outcome trial of ivabradine in chronic heart failure: the Systolic Heart Failure Treatment with the I(f) Inhibitor Ivabradine Trial (SHIFT). (19892778)
2010
30
Prognosis of mild/moderate chronic systolic heart failure. (20580102)
2010
31
Relationship between obesity and resting energy expenditure in systolic heart failure. (20591691)
2010
32
Case management for patients with chronic systolic heart failure in primary care: the HICMan exploratory randomised controlled trial. (20478035)
2010
33
Prognostic value of formulas estimating excretory renal function in the elderly with systolic heart failure. (19252204)
2009
34
Prediction clinical profile to distinguish between systolic and diastolic heart failure in hospitalized patients. (19393500)
2009
35
Tissue angiotensin-converting enzyme inhibitors for the prevention of cardiovascular disease in patients with diabetes mellitus without left ventricular systolic dysfunction or clinical evidence of heart failure: a pooled meta-analysis of randomized placebo-controlled clinical trials. (18095949)
2008
36
The effects of maximal treadmill graded exercise testing on haemorheological, haemodynamic and flow cytometry platelet markers in patients with systolic or diastolic heart failure. (18257777)
2008
37
Left ventricular systolic function in the prognosis of patients hospitalized due to worsening heart failure. (18488915)
2008
38
Effects of carvedilol on right ventricular ejection fraction and cytokines levels in patients with systolic heart failure. (18053592)
2008
39
Normal coronary arteries in patients with systolic heart failure who have higher body mass index. (17362793)
2007
40
Central sleep apnea, right ventricular dysfunction, and low diastolic blood pressure are predictors of mortality in systolic heart failure. (17512359)
2007
41
Statins and symptomatic chronic systolic heart failure: a post-hoc analysis of 5010 patients enrolled in Val-HeFT. (17049646)
2007
42
Usefulness of the aldosterone synthase gene polymorphism C-344-T to predict cardiac remodeling in African-Americans versus non-African-Americans with chronic systolic heart failure. (17631084)
2007
43
Epidemiology, pathophysiology, prognosis, and treatment of systolic and diastolic heart failure. (16628020)
2006
44
Disruption of caveolin-1 leads to enhanced nitrosative stress and severe systolic and diastolic heart failure. (16380094)
2006
45
Systolic and diastolic heart failure are associated with different plasma levels of B-type natriuretic peptide. (16033608)
2005
46
Update on outpatient treatment of systolic heart failure. (16225019)
2005
47
National patterns of use and effectiveness of angiotensin-converting enzyme inhibitors in older patients with heart failure and left ventricular systolic dysfunction. (15289383)
2004
48
Randomised double-blind, placebo-controlled trial of coenzyme Q, therapy in class II and III systolic heart failure. (18705154)
2003
49
Acute effects of cardiac resynchronization therapy on functional mitral regurgitation in advanced systolic heart failure. (12628720)
2003
50
Relation of atrial natriuretic peptides to left ventricular systolic and diastolic function in heart failure. (10937980)
1999

Genetic Variations for Systolic Heart Failure

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Expression for genes affiliated with Systolic Heart Failure

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Systolic Heart Failure

Search GEO for disease gene expression data for Systolic Heart Failure.

Pathways for genes affiliated with Systolic Heart Failure

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29KEGG, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems, 49PharmGKB
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Compounds for genes affiliated with Systolic Heart Failure

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Systolic Heart Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 195)
idCompoundScoreTop Affiliating Genes
1hydralazine44 49 1112.5CYP11B2
2captopril44 28 49 59 1114.0CST3, EDN1, NR3C2, MMP2
3bisoprolol44 49 1112.0NPPA, ACE, CYP2D6, NPPB
4trandolapril44 1111.0NPPB, EDN1, ACE, NPPA
5nebivolol44 1111.0CYP2D6, EDN1, ACE, NOS3
6hanp449.9NPPA, ADIPOQ, NPPB, EDN1
7chymostatin449.9CMA1, ACE, EDN1, AGT
8isosorbide dinitrate44 49 1111.9NPPA, EDN1, NOS3, ACE
9lisinopril44 11 2411.9ACE, NPPB, NPPA, AGT
10enalaprilat449.8NPPB, AGT, EDN1, NPPA, ACE
11celiprolol449.8ACE, NOS3, NPPB
12ramipril44 1110.8CST3, NPPB, NPPA, ADIPOQ, ACE
13norepinephrine44 11 2411.8UCN, NR3C2, CYP11B2, UCN2
14valsartan44 59 28 1112.8EDN1, ADIPOQ, ACE, AGT, NPPB
15spironolactone49 44 59 28 1113.8NPPB, CYP11B2, NPPA, ACE, NR3C2
16perindopril44 49 1111.8NPPB, NPPA, AGT, NOS3, ACE
17diltiazem44 28 1111.8AGT, EDN1, ACE, MMP2, CYP2D6
18irbesartan44 28 49 1112.7AGT, CYP11B2, ADIPOQ, CYP2D6, ACE
19telmisartan44 28 1111.7ADIPOQ, ACE, AGT, NPPB
20nitroglycerin44 1110.7EDN1, NPPB, NPPA, ACE, NOS3
21atenolol44 28 49 11 2413.7NPPB, CYP11B2, MMP2, AGT, ACE, CYP2D6
22n(g)-nitro-l-arginine methyl ester449.6EDN1, MMP2, AGT, NOS3
23carvedilol44 49 28 1112.6NOS3, ACE, EDN1, NPPA, NPPB, CYP2D6
24sildenafil44 49 28 11 2413.6NOS3, CYP2D6, NPPB, EDN1, NPPA, ACE
25l-nmma449.6NPPA, NPPB, EDN1, NOS3, AGT
26enalapril44 49 1111.6NPPB, NPPA, EDN1, AGT, ADIPOQ, ACE
27metoprolol44 28 49 11 2413.5CYP2D6, NOS3, NPPB, NPPA, ADIPOQ, ACE
28haloperidol44 28 2 49 1113.5AGT, CYP2D6, NR3C2, NPPA, NPPB, CYP11B2
29phenylephrine44 28 11 2412.5NOS3, EDN1, NPPA, AGT, NPPB, MMP2
308-isoprostane449.5ADIPOQ, NOS3, NPPB, MMP2, MPO, EDN1
31candesartan44 28 1111.5ADIPOQ, MMP2, AGT, NPPB, ACE, NOS3
32sodium44 2410.5ACE, AGT, NR3C2, EDN1, NPPB, CYP11B2
33felodipine44 28 1111.4NPPA, NR3C2, CYP2D6, ACE
34amlodipine44 49 11 2412.3NOS3, NPPA, AGT, ADIPOQ, NPPB, CYP2D6
35potassium44 11 2411.3NR3C2, UCN, CYP11B2, ACE, AGT
36nifedipine44 49 28 1112.3AGT, CYP11B2, EDN1, ADIPOQ, ACE, NPPA
37atorvastatin44 49 28 11 2413.3AGT, EDN1, NPPB, CYP2D6, MMP2, ADIPOQ
38dopamine44 28 11 2412.2CYP2D6, UCN, NPPB, NR3C2, AGT, UCN2
39ng-nitro-l-arginine449.2NPPA, EDN1, AGT, NOS3
40prostacyclin449.2AGT, EDN1, NOS3, ACE, ADIPOQ, NPPA
41dexamethasone44 49 28 1112.2NPPB, PDK4, NR3C2, AGT, CYP11B2, ADIPOQ
42ang ii449.2ACE, NPPA, EDN1, NOS3, CYP11B2, AGT
43losartan44 49 28 1112.1NR3C2, CYP11B2, ADIPOQ, ACE, AGT, EDN1
44acth448.9CYP11B2, UCN, UCN2, NPPA, NR3C2, AGT
45glucose448.7UCN, UCN2, PDK4, CST3, NR3C2, AGT
46creatinine448.6CST3, NPPB, AGT, MMP2, NPPA, EDN1
47arginine448.5ADIPOQ, NPPB, CST3, UCN, NOS3, CYP11B2
48acetylcholine44 49 28 11 2412.5CYP2D6, MPO, NOS3, ACE, ADIPOQ, AGT
49nitric oxide44 11 2410.1UCN2, NPPB, NPPA, EDN1, MPO, NR3C2
50calcium44 49 11 2410.9NPPA, UCN, NOS3, CMA1, MMP2, CYP11B2

GO Terms for genes affiliated with Systolic Heart Failure

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16Gene Ontology
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Cellular components related to Systolic Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1CST3, NPPB, NPPA, EDN1, MPO, AGT
2extracellular regionGO:0055767.4ADIPOQ, CORIN, UCN, UCN2, CST3, NPPB

Biological processes related to Systolic Heart Failure according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1regulation of renal sodium excretionGO:03581310.3AGT, CORIN
2regulation of renal output by angiotensinGO:00201910.3ACE, AGT
3cGMP biosynthetic processGO:00618210.3NPPA, NPPB
4artery smooth muscle contractionGO:01482410.3AGT, EDN1
5regulation of systemic arterial blood pressure by endothelinGO:00310010.3EDN1, NOS3
6body fluid secretionGO:00758910.3NPPB, EDN1
7regulation of vasodilationGO:04231210.2NPPB, ACE
8positive regulation of cardiac muscle hypertrophyGO:01061310.2EDN1, AGT
9angiotensin maturationGO:00200310.2ACE, CMA1, AGT
10positive regulation of renal sodium excretionGO:03581510.2NPPB, EDN1, AGT
11regulation of vasoconstrictionGO:01922910.2ACE, AGT, EDN1
12regulation of blood vessel sizeGO:05088010.1NPPB, NPPA, NOS3
13positive regulation of urine volumeGO:03581010.1EDN1, NPPB
14low-density lipoprotein particle remodelingGO:03437410.1MPO, AGT
15blood vessel remodelingGO:00197410.1ACE, NOS3, AGT
16negative regulation of hormone secretionGO:04688810.0UCN, EDN1, ADIPOQ
17receptor guanylyl cyclase signaling pathwayGO:00716810.0NPPB, NPPA
18female pregnancyGO:0075659.9NPPA, UCN, CORIN
19negative regulation of blood pressureGO:0457769.9UCN, NOS3, ADIPOQ
20regulation of blood pressureGO:0082179.8ACE, NOS3, NPPA, NPPB, CORIN
21regulation of glucose metabolic processGO:0109069.8PDK4, ADIPOQ
22proteolysisGO:0065089.7CORIN, MMP2, CMA1, ACE, ACY1
23positive regulation of cellular protein metabolic processGO:0322709.6ADIPOQ, AGT

Molecular functions related to Systolic Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:0200379.5MPO, CYP2D6, CYP11B2, NOS3
2corticotropin-releasing hormone receptor 2 bindingGO:0514319.5UCN2, UCN
3receptor bindingGO:0051029.4ADIPOQ, NPPA, NPPB, UCN2
4hormone activityGO:0051799.0ADIPOQ, AGT, EDN1, NPPA, NPPB, UCN2

Products for genes affiliated with Systolic Heart Failure

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Sources for Systolic Heart Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet