MCID: SYS003
MIFTS: 37

Systolic Heart Failure malady

Cardiovascular diseases category
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Summaries for Systolic Heart Failure

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33MalaCards
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MalaCards: Systolic Heart Failure, also known as heart failure, systolic, is related to hypertension and myocardial infarction. An important gene associated with Systolic Heart Failure is NPPB (natriuretic peptide B), and among its related pathways is Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds imidapril and aldosterone have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain.

Aliases & Classifications for Systolic Heart Failure

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Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 35MeSH, 27ICD9CM, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

systolic heart failure 8 10
heart failure, systolic 62


External Ids:

Disease Ontology8 DOID:9651
MeSH35 D054143
SNOMED-CT58 417996009
ICD9CM27 428.20, 428.2

Related Diseases for Systolic Heart Failure

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Systolic Heart Failure:



Diseases related to systolic heart failure

Symptoms for Systolic Heart Failure

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Drugs & Therapeutics for Systolic Heart Failure

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Systolic Heart Failure

Search NIH Clinical Center for Systolic Heart Failure

Genetic Tests for Systolic Heart Failure

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Anatomical Context for Systolic Heart Failure

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33MalaCards
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MalaCards organs/tissues related to Systolic Heart Failure:

33
Heart, Testes, Brain, Kidney, Bone, Endothelial, Skeletal muscle, Monocytes, T cells

Animal Models for Systolic Heart Failure or affiliated genes

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Publications for Systolic Heart Failure

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52PubMed
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Articles related to Systolic Heart Failure:

(show top 50)    (show all 488)
idTitleAuthorsYear
1
The large-scale placebo-controlled beta-blocker studies in systolic heart failure revisited: results from CIBIS-II, COPERNICUS and SENIORS-SHF compared with stratified subsets from MERIT-HF. (24118421)
2014
2
Effect of bosentan on pulmonary hypertension secondary to systolic heart failure. (24296902)
2013
3
ACP Journal Club. Review: in systolic heart failure, low-sodium diets increase mortality compared with normal-sodium diets. (23420258)
2013
4
Carotid body removal for treatment of chronic systolic heart failure. (23541331)
2013
5
Treatment of anemia with darbepoetin alfa in systolic heart failure. (23473338)
2013
6
Clinical course of patients with hyponatremia and decompensated systolic heart failure and the effect of vasopressin receptor antagonism with tolvaptan. (23743487)
2013
7
Predictive value of 6-min walk test distance versus cardiopulmonary exercise testing in systolic heart failure: same value for different approaches? (23524047)
2013
8
Ultrafiltration in heart failure with preserved ejection fraction: comparison with systolic heart failure patients. (23735537)
2013
9
Cardiac I123-MIBG correlates better than ejection fraction with symptoms severity in systolic heart failure. (23917506)
2013
10
Transthoracic bioimpedance and brain natriuretic peptide assessment for prognostic stratification of outpatients with chronic systolic heart failure. (23377871)
2013
11
Aerobic exercise effect on prognostic markers for systolic heart failure patients: a systematic review and meta-analysis. (24129770)
2013
12
Diminished global arginine bioavailability as a metabolic defect in chronic systolic heart failure. (23384633)
2013
13
Right ventricular dysfunction is associated with chronic kidney disease and predicts survival in patients with chronic systolic heart failure. (22357576)
2012
14
Impact of right ventricular pacing on patients with Chagas cardiomyopathy with chronic systolic heart failure. (22104987)
2012
15
Increased exhaled nitric oxide levels after exercise in patients with chronic systolic heart failure with pulmonary venous hypertension. (23040116)
2012
16
Role of ACE2 in diastolic and systolic heart failure. (21638102)
2012
17
Use of cystatin C levels in estimating renal function and prognosis in patients with chronic systolic heart failure. (22038544)
2012
18
Systolic heart failure and anesthetic considerations. (22735724)
2012
19
Association between systemic neutrophil gelatinase-associated lipocalin and anemia, relative hypochromia, and inflammation in chronic systolic heart failure. (22994438)
2012
20
Routine serial echocardiography in systolic heart failure: is it time for the heart failure guidelines to change? (21449997)
2011
21
Prognostic significance of anemia in patients with chronic systolic heart failure secondary to Chagas' cardiomyopathy. (21906579)
2011
22
PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study. (21036891)
2011
23
Identifying important risk factors for survival in patient with systolic heart failure using random survival forests. (21098782)
2011
24
Prevalence of stroke in systolic heart failure. (21187266)
2011
25
Integrating plasma high-sensitivity C-reactive protein and myeloperoxidase for risk prediction in chronic systolic heart failure. (21609382)
2011
26
Careful echocardiographic analysis of right ventricular function as a long-term prognostic variable in systolic heart failure. (21817818)
2011
27
Echocardiographic evaluation of hemodynamics in patients with decompensated systolic heart failure. (21398512)
2011
28
Systolic heart failure. (20410523)
2010
29
Drug treatment for chronic systolic heart failure. (20101534)
2010
30
Circulating matrix metalloproteinase-3 and metalloproteinase-9 and tissue Doppler measures of diastolic dysfunction to risk stratify patients with systolic heart failure. (20211331)
2010
31
A comprehensive noninvasive hemodynamic assessment of systolic heart failure. (20484194)
2010
32
We should not hesitate to use beta-blockers for systolic heart failure with concomitant renal dysfunction. (20647630)
2010
33
Epidemiology and survival of the five stages of chronic kidney disease in a systolic heart failure population. (20484366)
2010
34
Intermittent claudication as a predictor of outcome in patients with ischaemic systolic heart failure: analysis of the Controlled Rosuvastatin Multinational Trial in Heart Failure trial (CORONA). (20501489)
2010
35
Impact of baseline systolic blood pressure on long-term outcomes in patients with advanced chronic systolic heart failure (insights from the BEST trial). (20599007)
2010
36
Myocardial performance (Tei) index is normal in diastolic and systolic heart failure induced by pressure overload in rats. (20562113)
2010
37
Primary care-based multifaceted, interdisciplinary medical educational intervention for patients with systolic heart failure: lessons learned from a cluster randomised controlled trial. (19678944)
2009
38
Prognostic value of formulas estimating excretory renal function in the elderly with systolic heart failure. (19252204)
2009
39
Serum oxidative stress level correlates with clinical parameters in chronic systolic heart failure patients. (19353709)
2009
40
Effects of L-arginine on the Minnesota Living with Heart Failure Questionnaire quality-of-life score in patients with chronic systolic heart failure. (19946230)
2009
41
Influence of atrial fibrillation on plasma von willebrand factor, soluble E-selectin, and N-terminal pro B-type natriuretic peptide levels in systolic heart failure. (18339785)
2008
42
Usefulness of C-reactive protein and left ventricular diastolic performance for prognosis in patients with left ventricular systolic heart failure. (18237602)
2008
43
Long-term prognosis and risk factors for cardiac adverse events in patients with chronic systolic heart failure due to hypertension. (18619178)
2008
44
Left atrial remodeling in patients younger than 70 years with diastolic and systolic heart failure. (17275704)
2007
45
Switching to once-daily evidence-based [beta]-blockers in patients with systolic heart failure or left ventricular dysfunction after myocardial infarction. (18032686)
2007
46
Mode of death in patients with systolic heart failure. (17562783)
2007
47
CORONA study highlights challenges of treating older patients with systolic heart failure. (18092121)
2007
48
Illness representation of patients with systolic heart failure. (17170594)
2006
49
Comparison of African-American patients with systolic heart failure versus preserved ejection fraction. (16950190)
2006
50
Cytokines and immune activation in systolic heart failure: the role of Type D personality. (12831833)
2003

Variations for Systolic Heart Failure

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Expression for genes affiliated with Systolic Heart Failure

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Systolic Heart Failure

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Pathways for genes affiliated with Systolic Heart Failure

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50PathCards, 51PharmGKB, 30KEGG, 38NCBI BioSystems Database
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Pathways related to Systolic Heart Failure according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3CMA1, CYP11B2

Compounds for genes affiliated with Systolic Heart Failure

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Sources:
45Novoseek, 51PharmGKB, 29IUPHAR, 24HMDB, 11DrugBank, 61Tocris Bioscience, 3BitterDB
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Compounds related to Systolic Heart Failure according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1imidapril45 5110.8NPPB, CYP11B2
2aldosterone29 24 1111.8NPPB, CYP11B2
3candesartan45 51 29 1112.8NPPB, CYP11B2
4spironolactone45 61 29 51 1113.8NPPB, CYP11B2
5ang ii459.8CYP11B2, NPPB
6losartan45 51 29 1112.8NPPB, CYP11B2
7haloperidol45 51 29 3 1113.7CYP11B2, NPPB
8procollagen459.7NPPB, CMA1
9p002459.6NPPB, CYP11B2
10phenylephrine45 29 24 1112.5ADRA2A, NPPB
11histamine45 29 2411.4NPPB, CMA1
12catecholamine459.4NPPB, ADRA2A
13isoproterenol45 1110.2NPPB, ADRA2A
14Water249.2NPPB, ACY1, CYP11B2
15atenolol45 51 29 24 1113.0NPPB, ADRA2A, CYP11B2
16norepinephrine45 24 1111.0CYP11B2, ADRA2A, NPPB
17progesterone45 29 61 24 1113.0NPPB, ADRA2A, CYP11B2
18testosterone45 61 24 1112.0NPPB, ADRA2A, CYP11B2
19epinephrine45 24 1110.9NPPB, ADRA2A
20glucose458.7NPPB, ADRA2A, CYP11B2
21cysteine458.7CMA1, ADRA2A, NPPB
22lipid458.6CYP11B2, ADRA2A, NPPB
23calcium45 51 24 1111.3CYP11B2, CMA1, ADRA2A, NPPB

GO Terms for genes affiliated with Systolic Heart Failure

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16Gene Ontology
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Biological processes related to Systolic Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to hormone stimulusGO:0328709.1ADRA2A, CYP11B2

Products for genes affiliated with Systolic Heart Failure

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Systolic Heart Failure

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet