MCID: SYS003
MIFTS: 48

Systolic Heart Failure malady

Summaries for Systolic Heart Failure

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33MalaCards
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MalaCards: Systolic Heart Failure, also known as heart failure, systolic, is related to coronary heart disease and coronary artery disease,. An important gene associated with Systolic Heart Failure is NPPB (natriuretic peptide B), and among its related pathways are Renin-angiotensin system and MicroRNAs in cardiomyocyte hypertrophy. The compounds hydralazine and captopril have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and skeletal muscle, and related mouse phenotypes are renal/urinary system and muscle.

Aliases & Classifications for Systolic Heart Failure

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH
See all sources

Aliases & Descriptions:

systolic heart failure 8 10
heart failure, systolic 61


External Ids:

Disease Ontology8 DOID:9651
ICD9CM27 428.20, 428.2
SNOMED-CT57 417996009
MeSH35 D054143

Related Diseases for Systolic Heart Failure

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Systolic Heart Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1coronary heart disease30.8CST3, NPPB, EDN1, ADIPOQ, ACE, NOS3
2coronary artery disease,30.8NPPB, ACE, CST3, AGT, ADIPOQ, NOS3
3chagas disease30.6NPPB
4central sleep apnea30.4NPPB
5acute myocardial infarction30.4ACE, AGT, NR3C2, EDN1, NPPA, NPPB
6insulin resistance30.2CYP2D6, NOS3, ACE, ADIPOQ, AGT, NR3C2
7diastolic heart failure10.9
8sleep apnea10.5
9sleep disorder10.4
10heart tumor10.3
11autonomic dysfunction10.3
12pulmonary function10.3
13angina pectoris10.1
14intermittent claudication10.1
15hypertrophic cardiomyopathy10.1
16devic disease10.1
17single ventricular heart10.1
18headache10.1
19hypoxia10.1
20hypertension, diastolic10.1
21pulmonary disease, chronic obstructive10.1
22myocarditis10.0NPPB
23pulmonary embolism10.0NPPB
24kawasaki disease10.0NPPB
25congestive heart failure10.0SHF
26gastritis10.0UCN
27hypothyroidism10.0CST3
28galactosemia10.0CYP2D6
29glaucoma10.0EDN1
30migraine10.0CYP2D6
31gingivitis10.0CST3
32rhinitis10.0CMA1
33hepatitis c10.0CYP2D6
34hypoaldosteronism10.0CYP11B2
35eating disorder10.0NPPB
36glomerulonephritis10.0MPO
37cystic fibrosis10.0MPO
38inflammatory bowel disease10.0MPO
39oligohydramnios10.0ACE
40panic disorder10.0UCN
41hepatitis10.0CYP2D6
42anuria10.0ACE
43pneumonia10.0MPO
44vasculitis10.0MPO
45cushing's syndrome10.0CYP11B2
46deficiency anemia10.0ACE
47pancreatitis10.0MPO
48meningioma10.0CST3
49thromboembolism10.0NOS3
50mitral valve disease10.0NPPA

Graphical network of the top 20 diseases related to Systolic Heart Failure:



Diseases related to systolic heart failure

Clinical Features for Systolic Heart Failure

Drugs & Therapeutics for Systolic Heart Failure

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Systolic Heart Failure

Drug clinical trials:

Search ClinicalTrials for Systolic Heart Failure

Search NIH Clinical Center for Systolic Heart Failure

Search CenterWatch for Systolic Heart Failure

Genetic Tests for Systolic Heart Failure

Anatomical Context for Systolic Heart Failure

Sources:
33MalaCards
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MalaCards organs/tissues related to Systolic Heart Failure:

33
Brain, Heart, Skeletal muscle, Kidney, Monocytes, T cells, B cells, Endothelial

Animal Models for Systolic Heart Failure or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Systolic Heart Failure:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.9ADIPOQ, CORIN, EDN1, NR3C2, AGT, ACE
2MP:00053697.8CORIN, ADIPOQ, NOS3, MMP2, CYP11B2, AGT
3MP:00053857.5AGT, ADIPOQ, CST3, NPPB, CORIN, NPPA
4MP:00053766.3CST3, ADIPOQ, CORIN, NPPA, EDN1, NR3C2

Publications for Systolic Heart Failure

Sources:
51PubMed
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Articles related to Systolic Heart Failure:

(show top 50)    (show all 629)
idTitleAuthorsYear
1
Carotid body removal for treatment of chronic systolic heart failure. (23541331)
2013
2
Multivariate miRNA signatures as biomarkers for non-ischaemic systolic heart failure. (23864135)
2013
3
Anabolic deficiencies in men with systolic heart failure: do co-morbidities and therapies really contribute significantly? (23803163)
2013
4
Darbepoetin alfa in systolic heart failure. (23902504)
2013
5
A simple validated clinical tool to predict the absence of coronary artery disease in patients with systolic heart failure of unclear etiology. (23891428)
2013
6
Potential role of BNIP3 in cardiac remodeling, myocardial stiffness, and endoplasmic reticulum: mitochondrial calcium homeostasis in diastolic and systolic heart failure. (23508759)
2013
7
Influence of mildronat on left ventricular systolic, diastolic functional parameters, pulmonary arterial flow and systolic dyssynchrony in patients with congestive heart failure. (23787504)
2013
8
Effects of enalapril in systolic heart failure patients with and without chronic kidney disease: insights from the SOLVD Treatment trial. (22257685)
2013
9
Reduced right ventricular ejection fraction and increased mortality in chronic systolic heart failure patients receiving I^-blockers: insights from the BEST trial. (21704392)
2013
10
Anemia and associated clinical outcomes in patients with heart failure due to reduced left ventricular systolic function. (23929781)
2013
11
Dangerous liaison: successful percutaneous edge-to-edge mitral valve repair in patients with end-stage systolic heart failure can cause left ventricular thrombus formation. (24168894)
2013
12
Prognostic significance of cardiovascular biomarkers and renal dysfunction in outpatients with systolic heart failure: a long term follow-up study. (24182673)
2013
13
Systolic heart failure and anesthetic considerations. (22735724)
2012
14
Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. (23224924)
2012
15
Effect of ivabradine on recurrent hospitalization for worsening heart failure in patients with chronic systolic heart failure: the SHIFT Study. (22927555)
2012
16
PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study. (21036891)
2011
17
Identifying important risk factors for survival in patient with systolic heart failure using random survival forests. (21098782)
2011
18
Prevalence of stroke in systolic heart failure. (21187266)
2011
19
The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial. (21856481)
2011
20
Neuregulin-1I^ for the treatment of systolic heart failure. (21729703)
2011
21
Right atrial speckle tracking analysis as a novel noninvasive method for pulmonary hemodynamics assessment in patients with chronic systolic heart failure. (21676018)
2011
22
Relationship between left and right ventricular ejection fractions in chronic advanced systolic heart failure: insights from the BEST trial. (21097899)
2011
23
Systolic heart failure. (20410523)
2010
24
Prevalence of electrocardiographic abnormalities in a systolic heart failure disease management population by race, ethnicity, and sex. (20078624)
2010
25
Mortality and morbidity of non-systolic heart failure treated with angiotensin-converting enzyme inhibitors: a propensity-adjusted case-control study. (19064293)
2010
26
Impact of reduced kidney function on cardiopulmonary fitness in patients with systolic heart failure. (20664198)
2010
27
Subtle systolic dysfunction may be associated with the tendency to develop diastolic heart failure in patients with preserved left ventricular ejection fraction. (19382943)
2009
28
Rosuvastatin in older patients with systolic heart failure. (19097304)
2009
29
Relationships between plasma adrenomedullin concentration and systolic time intervals during static handgrip in patients with heart failure. (19207415)
2009
30
Difference in prevalence and pattern of mechanical dyssynchrony in left bundle branch block occurring in right ventricular apical pacing versus systolic heart failure. (19061717)
2008
31
Accuracy of the isovolumic relaxation time in the emergency diagnosis of new-onset congestive heart failure with preserved left ventricular systolic function in the setting of B-type natriuretic peptide levels in the mid-range. (17395301)
2008
32
Provocation of masked left ventricular mechanical dyssynchrony by treadmill exercise in patients with systolic heart failure and narrow QRS complex. (18308016)
2008
33
Albumin levels predict survival in patients with systolic heart failure. (18440336)
2008
34
Microalbuminuria in nondiabetic and nonhypertensive systolic heart failure patients. (18983285)
2008
35
Switching to once-daily evidence-based [beta]-blockers in patients with systolic heart failure or left ventricular dysfunction after myocardial infarction. (18032686)
2007
36
Arg389Gly-beta1-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol. (18075464)
2007
37
Multicenter, randomized, double-blind, placebo-controlled study on the effect of oral tolvaptan on left ventricular dilation and function in patients with heart failure and systolic dysfunction. (17543634)
2007
38
Double-blind, randomized, placebo-controlled study of high-dose HMG CoA reductase inhibitor therapy on ventricular remodeling, pro-inflammatory cytokines and neurohormonal parameters in patients with chronic systolic heart failure. (17338996)
2007
39
Outcome of pharmacological rhythm control for new-onset persistent atrial fibrillation in patients with systolic heart failure: a comparison with patients with normal left ventricular function. (17332026)
2007
40
Prognostic usefulness of anemia and N-terminal pro-brain natriuretic peptide in outpatients with systolic heart failure. (17996522)
2007
41
Ventriculovascular coupling in systolic and diastolic heart failure. (17543251)
2006
42
Atorvastatin improves left ventricular systolic function and serum markers of inflammation in nonischemic heart failure. (16412856)
2006
43
Heart failure due to left ventricular systolic dysfunction: treatment at discharge from hospital and at one year. (16098391)
2005
44
The role of brain natriuretic peptide in systolic heart failure. (16043978)
2005
45
Prognostic impact of matrix metalloproteinase gene polymorphisms in patients with heart failure according to the aetiology of left ventricular systolic dysfunction. (15084374)
2004
46
Exercise responses of elderly patients with diastolic versus systolic heart failure. (12972865)
2003
47
Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial. (13678869)
2003
48
Body composition and prognosis in chronic systolic heart failure: the obesity paradox. (12667583)
2003
49
Differentiating systolic from diastolic heart failure using impedance cardiography. (10433528)
1999
50
Quality of life in older patients with systolic and diastolic heart failure. (10937925)
1999

Genetic Variations for Systolic Heart Failure

Expression for genes affiliated with Systolic Heart Failure

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Systolic Heart Failure

Search GEO for disease gene expression data for Systolic Heart Failure.

Pathways for genes affiliated with Systolic Heart Failure

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 53R&D Systems, 50PharmGKB
See all sources

Compounds for genes affiliated with Systolic Heart Failure

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Systolic Heart Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 195)
idCompoundScoreTop Affiliating Genes
1hydralazine45 50 1112.5CYP11B2
2captopril45 29 50 60 1114.0CST3, EDN1, NR3C2, MMP2
3bisoprolol45 50 1112.0NPPA, ACE, CYP2D6, NPPB
4trandolapril45 1111.0NPPB, EDN1, ACE, NPPA
5nebivolol45 1111.0CYP2D6, EDN1, ACE, NOS3
6hanp459.9NPPA, ADIPOQ, NPPB, EDN1
7chymostatin459.9CMA1, ACE, EDN1, AGT
8candoxatril45 1110.9ACE, NPPA, NPPB
9isosorbide dinitrate45 50 1111.9NPPA, EDN1, NOS3, ACE
10lisinopril45 11 2411.9ACE, NPPB, NPPA, AGT
11enalaprilat459.8NPPB, AGT, EDN1, NPPA, ACE
12ramipril45 1110.8CST3, NPPB, NPPA, ADIPOQ, ACE
13norepinephrine45 11 2411.8UCN, NR3C2, CYP11B2, UCN2
14valsartan45 60 29 1112.8EDN1, ADIPOQ, ACE, AGT, NPPB
15spironolactone50 45 60 29 1113.8NPPB, CYP11B2, NPPA, ACE, NR3C2
16perindopril45 50 1111.8NPPB, NPPA, AGT, NOS3, ACE
17diltiazem45 29 1111.8AGT, EDN1, ACE, MMP2, CYP2D6
18irbesartan45 29 50 1112.7AGT, CYP11B2, ADIPOQ, CYP2D6, ACE
19telmisartan45 29 1111.7ADIPOQ, ACE, AGT, NPPB
20nitroglycerin45 1110.7EDN1, NPPB, NPPA, ACE, NOS3
21atenolol45 29 50 11 2413.7NPPB, CYP11B2, MMP2, AGT, ACE, CYP2D6
22n(g)-nitro-l-arginine methyl ester459.6EDN1, MMP2, AGT, NOS3
23carvedilol45 50 29 1112.6NOS3, ACE, EDN1, NPPA, NPPB, CYP2D6
24sildenafil45 50 29 11 2413.6NOS3, CYP2D6, NPPB, EDN1, NPPA, ACE
25l-nmma459.6NPPA, NPPB, EDN1, NOS3, AGT
26enalapril45 50 1111.6NPPB, NPPA, EDN1, AGT, ADIPOQ, ACE
27metoprolol45 29 50 11 2413.5CYP2D6, NOS3, NPPB, NPPA, ADIPOQ, ACE
28haloperidol45 29 2 50 1113.5AGT, CYP2D6, NR3C2, NPPA, NPPB, CYP11B2
29phenylephrine45 29 11 2412.5NOS3, EDN1, NPPA, AGT, NPPB, MMP2
308-isoprostane459.5ADIPOQ, NOS3, NPPB, MMP2, MPO, EDN1
31candesartan45 29 1111.5ADIPOQ, MMP2, AGT, NPPB, ACE, NOS3
32sodium45 2410.5ACE, AGT, NR3C2, EDN1, NPPB, CYP11B2
33felodipine45 29 1111.4NPPA, NR3C2, CYP2D6, ACE
34amlodipine45 50 11 2412.3NOS3, NPPA, AGT, ADIPOQ, NPPB, CYP2D6
35potassium45 11 2411.3NR3C2, UCN, CYP11B2, ACE, AGT
36nifedipine45 50 29 1112.3AGT, CYP11B2, EDN1, ADIPOQ, ACE, NPPA
37atorvastatin45 50 29 11 2413.3AGT, EDN1, NPPB, CYP2D6, MMP2, ADIPOQ
38dopamine45 29 11 2412.2CYP2D6, UCN, NPPB, NR3C2, AGT, UCN2
39ng-nitro-l-arginine459.2NPPA, EDN1, AGT, NOS3
40prostacyclin459.2AGT, EDN1, NOS3, ACE, ADIPOQ, NPPA
41dexamethasone45 50 29 1112.2NPPB, PDK4, NR3C2, AGT, CYP11B2, ADIPOQ
42ang ii459.2ACE, NPPA, EDN1, NOS3, CYP11B2, AGT
43losartan45 50 29 1112.1NR3C2, CYP11B2, ADIPOQ, ACE, AGT, EDN1
44acth458.9CYP11B2, UCN, UCN2, NPPA, NR3C2, AGT
45glucose458.7UCN, UCN2, PDK4, CST3, NR3C2, AGT
46creatinine458.6CST3, NPPB, AGT, MMP2, NPPA, EDN1
47arginine458.5ADIPOQ, NPPB, CST3, UCN, NOS3, CYP11B2
48acetylcholine45 50 29 11 2412.5CYP2D6, MPO, NOS3, ACE, ADIPOQ, AGT
49nitric oxide45 11 2410.1UCN2, NPPB, NPPA, EDN1, MPO, NR3C2
50calcium45 50 11 2410.9NPPA, UCN, NOS3, CMA1, MMP2, CYP11B2

GO Terms for genes affiliated with Systolic Heart Failure

Sources:
16Gene Ontology
See all sources

Cellular components related to Systolic Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1CST3, NPPB, NPPA, EDN1, MPO, AGT
2extracellular regionGO:0055767.4ADIPOQ, CORIN, UCN, UCN2, CST3, NPPB

Biological processes related to Systolic Heart Failure according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1regulation of renal sodium excretionGO:03581310.3AGT, CORIN
2regulation of renal output by angiotensinGO:00201910.3ACE, AGT
3cGMP biosynthetic processGO:00618210.3NPPA, NPPB
4artery smooth muscle contractionGO:01482410.3AGT, EDN1
5regulation of systemic arterial blood pressure by endothelinGO:00310010.3EDN1, NOS3
6body fluid secretionGO:00758910.3NPPB, EDN1
7regulation of vasodilationGO:04231210.2NPPB, ACE
8positive regulation of cardiac muscle hypertrophyGO:01061310.2EDN1, AGT
9angiotensin maturationGO:00200310.2ACE, CMA1, AGT
10positive regulation of renal sodium excretionGO:03581510.2NPPB, EDN1, AGT
11regulation of vasoconstrictionGO:01922910.2ACE, AGT, EDN1
12regulation of blood vessel sizeGO:05088010.1NPPB, NPPA, NOS3
13positive regulation of urine volumeGO:03581010.1EDN1, NPPB
14low-density lipoprotein particle remodelingGO:03437410.1MPO, AGT
15blood vessel remodelingGO:00197410.1ACE, NOS3, AGT
16negative regulation of hormone secretionGO:04688810.0UCN, EDN1, ADIPOQ
17receptor guanylyl cyclase signaling pathwayGO:00716810.0NPPB, NPPA
18female pregnancyGO:0075659.9NPPA, UCN, CORIN
19negative regulation of blood pressureGO:0457769.9UCN, NOS3, ADIPOQ
20regulation of blood pressureGO:0082179.8ACE, NOS3, NPPA, NPPB, CORIN
21regulation of glucose metabolic processGO:0109069.8PDK4, ADIPOQ
22proteolysisGO:0065089.7CORIN, MMP2, CMA1, ACE, ACY1
23positive regulation of cellular protein metabolic processGO:0322709.6ADIPOQ, AGT

Molecular functions related to Systolic Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:0200379.5CYP2D6, MPO, CYP11B2, NOS3
2corticotropin-releasing hormone receptor 2 bindingGO:0514319.5UCN2, UCN
3receptor bindingGO:0051029.4UCN2, NPPB, NPPA, ADIPOQ
4hormone activityGO:0051799.0NPPB, UCN2, NPPA, EDN1, AGT, ADIPOQ

Products for genes affiliated with Systolic Heart Failure

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  • Antibodies

Sources for Systolic Heart Failure

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet