MCID: SYS003
MIFTS: 43

Systolic Heart Failure

Categories: Cardiovascular diseases

Aliases & Classifications for Systolic Heart Failure

MalaCards integrated aliases for Systolic Heart Failure:

Name: Systolic Heart Failure 12 14
Heart Failure, Systolic 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9651
ICD10 33 I50.20
ICD9CM 35 428.2 428.20
MeSH 42 D054143
SNOMED-CT 64 417996009
UMLS 69 C1135191

Summaries for Systolic Heart Failure

MalaCards based summary : Systolic Heart Failure, also known as heart failure, systolic, is related to heart disease and ischemic heart disease. An important gene associated with Systolic Heart Failure is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Development and heterogeneity of the ILC family and Antifolate resistance. The drugs Carvedilol and Verapamil have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Systolic Heart Failure

Diseases related to Systolic Heart Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 214)
id Related Disease Score Top Affiliating Genes
1 heart disease 30.5 ACE CRP
2 ischemic heart disease 29.9 ACE CRP IL6
3 angina pectoris 29.6 ACE CRP IL6
4 peripheral artery disease 28.6 ACE CRP IL6 NPPB TNF
5 myocardial infarction 26.3 ACE ADRB1 CRP CST3 IL6 NPPB
6 synovial chondromatosis 10.7 ACE NPPB
7 dementia pugilistica 10.7 IL6 NPPB
8 congenital nonspherocytic hemolytic anemia 10.7 IL6 NPPB
9 pleomorphic liposarcoma 10.7 ACE NPPB
10 trichinosis 10.7 ACE NPPB
11 cryptogenic late-onset epileptic spasms 10.7 ACE TNF
12 cardiac sarcoidosis 10.6 ACE TNF
13 neuromuscular disease 10.6 ACE TNF
14 herpangina 10.6 IL6 NPPB
15 smarca4-deficient sarcoma of thorax 10.6 IL6 TNF
16 aortic arch interruption 10.6 IL6 TNF
17 cutaneous leishmaniasis 10.6 IL6 TNF
18 spirillary rat-bite fever 10.6 IL6 TNF
19 toxoplasmosis 10.6 IL6 TNF
20 dyslexia 5 10.6 IL6 TNF
21 scrotal carcinoma 10.6 IL6 TNF
22 anencephaly and spina bifida x-linked 10.6 IL6 TNF
23 antigen-peptide-transporter 2 deficiency 10.6 IL6 TNF
24 papilledema 10.6 IL6 TNF
25 ethmoid sinus adenocarcinoma 10.6 IL6 TNF
26 suppurative otitis media 10.6 ACE NPPB
27 upper gum cancer 10.6 IL6 TNF
28 bipolar i disorder 10.6 IL6 TNF
29 lymphocytic colitis 10.5 IL6 TNF
30 pasteurellosis 10.5 IL6 TNF
31 tinea favosa 10.5 IL6 TNF
32 pyriform sinus cancer 10.5 HSPB7 NPPB
33 indolent myeloma 10.5 IL6 TNF
34 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 10.5 IL6 TNF
35 adenocarcinoma 10.5 ACE NR3C2
36 broad ligament malignant neoplasm 10.5 ACE NPPB
37 vogt-koyanagi-harada disease 10.5 IL6 TNF
38 tricho onychic dysplasia 10.5 IL6 TNF
39 phlyctenulosis 10.5 IL6 TNF
40 cyclosporiasis 10.5 IL6 TNF
41 hypogonadotropism 10.5 IL6 TNF
42 early-onset zonular cataract 10.5 IL6 TNF
43 primary biliary cirrhosis 10.5 IL6 TNF
44 hepadnavirus infection 10.5 IL6 TNF
45 ciliary discoordination, due to random ciliary orientation 10.4 CRP NPPB
46 tracheal stenosis 10.4 IL6 TNF
47 iron metabolism disease 10.4 ACE CRP
48 retinal arteries, tortuosity of 10.4 ACE CST3
49 cytomegalovirus disease in patients with impaired cell mediated immunity deemed at risk 10.4 IL6 TNF
50 ulcerative colitis 10.4 IL6 TNF

Graphical network of the top 20 diseases related to Systolic Heart Failure:



Diseases related to Systolic Heart Failure

Symptoms & Phenotypes for Systolic Heart Failure

MGI Mouse Phenotypes related to Systolic Heart Failure:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 ACE ADRB1 CORIN CRP CST3 IL6
2 homeostasis/metabolism MP:0005376 9.56 ACE ADRB1 CORIN CRP CST3 IL6
3 muscle MP:0005369 9.1 TNF ADRB1 CORIN CST3 IL6 NR3C2

Drugs & Therapeutics for Systolic Heart Failure

Drugs for Systolic Heart Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 326)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carvedilol Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 72956-09-3 2585
2
Verapamil Approved Phase 4 52-53-9 2520
3
Bisoprolol Approved Phase 4 66722-44-9 2405
4
Candesartan Approved Phase 4,Phase 3 139481-59-7 2541
5
Captopril Approved Phase 4 62571-86-2 44093
6
Enalapril Approved, Vet_approved Phase 4,Phase 2,Phase 3 75847-73-3 5362032 40466924
7
Enalaprilat Approved Phase 4,Phase 2,Phase 3 76420-72-9 6917719
8
Eplerenone Approved Phase 4,Phase 3,Phase 2 107724-20-9 150310 443872
9
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
10
Metoprolol Approved, Investigational Phase 4,Phase 3,Phase 2 37350-58-6, 51384-51-1 4171
11
Nebivolol Approved, Investigational Phase 4,Phase 2,Phase 3 152520-56-4, 99200-09-6, 118457-14-0 71301
12
Ramipril Approved Phase 4,Phase 3,Phase 2 87333-19-5 5362129
13
Spironolactone Approved Phase 4,Phase 3,Phase 2 1952-01-7, 52-01-7 5833
14
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 2 137862-53-4 60846
15
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
16
Doxorubicin Approved, Investigational Phase 4 23214-92-8 31703
17
Epirubicin Approved Phase 4 56420-45-2 41867
18
Fluorouracil Approved Phase 4 51-21-8 3385
19
Digoxin Approved Phase 4,Phase 2,Phase 3,Phase 1 20830-75-5 30322 2724385
20
Hydralazine Approved Phase 4,Phase 3,Phase 2,Phase 1 86-54-4 3637
21
Nitroglycerin Approved, Investigational Phase 4,Phase 3,Phase 2 55-63-0 4510
22
Benzocaine Approved Phase 4,Phase 3 1994-09-7, 94-09-7 2337
23
Dobutamine Approved Phase 4,Phase 2 34368-04-2 36811
24
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1 10102-43-9 145068
25
Amiodarone Approved, Investigational Phase 4,Phase 2 1951-25-3 2157
26
Sotalol Approved Phase 4 959-24-0, 3930-20-9 5253
27
Ticlopidine Approved Phase 4 55142-85-3 5472
28
Benazepril Approved, Investigational Phase 4 86541-75-5 5362124
29
Trandolapril Approved Phase 4 87679-37-6 5484727
30
Furosemide Approved, Vet_approved Phase 4,Phase 2 54-31-9 3440
31
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
32 Racepinephrine Approved Phase 4
33
Doxazosin Approved Phase 4 74191-85-8 3157
34
Iron Approved Phase 4,Phase 2,Phase 3 7439-89-6 23925
35
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
36
Amlodipine Approved Phase 4,Phase 2,Phase 3 88150-42-9 2162
37
Tadalafil Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 171596-29-5 110635
38
Canagliflozin Approved Phase 4 842133-18-0
39
Metformin Approved Phase 4,Phase 2,Phase 1 657-24-9 14219 4091
40
Povidone Approved Phase 4 9003-39-8
41 Povidone-iodine Approved Phase 4 25655-41-8
42
Empagliflozin Approved Phase 4,Phase 2 864070-44-0
43
Nitroprusside Approved Phase 4 15078-28-1 11963622
44
Propafenone Approved Phase 4 54063-53-5 4932
45
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
46
Norethindrone Approved Phase 4 68-22-4 6230
47
Losartan Approved Phase 4 114798-26-4 3961
48 tannic acid Approved, Nutraceutical Phase 4,Phase 3
49
Clopidogrel Approved, Nutraceutical Phase 4 120202-66-6, 113665-84-2 60606
50
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037

Interventional clinical trials:

(show top 50) (show all 549)

id Name Status NCT ID Phase Drugs
1 Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism Unknown status NCT02316743 Phase 4 Levothyroxine supplementation
2 Medtronic South Asian Systolic Heart Failure Registry Unknown status NCT01434615 Phase 4
3 Carvedilol Versus Verapamil in Chronic Heart Failure Secondary to Non-Ischemic Cardiomyopathy Unknown status NCT00348530 Phase 4 Verapamil
4 Shensong Yangxin Capsule in the Treatment of Heart Failure Complicated With Ventricular Premature Beat Unknown status NCT01612260 Phase 4 Shensong Yangxin capsule;placebo Capsule
5 Danish ICD Study in Patients With Dilated Cardiomyopathy Unknown status NCT00542945 Phase 4
6 Significance of Regional Ventriculo-arterial Coupling in Patients With Chronic Heart Failure Unknown status NCT01156207 Phase 4 Aliskiren
7 Erythropoietin Treatment in Patients With Systolic Left Ventricular Dysfunction, Mild Anemia and Normal Renal Function Unknown status NCT00418119 Phase 4 erythropoietin
8 Quadripolar Leads for the Management of Heart Failure Patients in the Middle East Unknown status NCT02195843 Phase 4
9 Effects of Atrial Rate-adaptive Pacing on Exercise Capacity in Patients With Chronic Heart Failure Complicated by Chronotropic Incompetence Unknown status NCT01016431 Phase 4
10 St. Vincent's Screening To Prevent Heart Failure Study Unknown status NCT00921960 Phase 4
11 Systematic Withdrawal of Neurohumoral Blocker Therapy in Optimally Responding CRT Patients Unknown status NCT02200822 Phase 4 beta blockers;RAAS blockers
12 Revascularization in Heart Failure Trial – REHEAT 2 Unknown status NCT00388245 Phase 4
13 Changes of Left Ventricular Mass and Cardiac Function in Patients With Active Acromegaly During Treatment With the Growth Hormone Receptor Antagonist Pegvisomant Unknown status NCT00552851 Phase 4 pegvisomant
14 A Study of Liposomal Doxorubicin in Women With Breast Cancer Exploiting Tissue Doppler Imaging Unknown status NCT00531973 Phase 4 liposomal doxorubicin;epirubicin
15 Platelet Inhibition in Patients With Systolic Heart Failure Completed NCT01765400 Phase 4 Prasugrel 10 mg daily x 2 weeks;Clopidogrel 75 mg daily x 2 weeks
16 A Prospective, Open-labeled, Multi-centric Trial in Subjects With Systolic Heart Failure to Evaluate Bisoprolol Treatment for the Effects on Surrogate Markers of Heart Failure in Korea Completed NCT01074307 Phase 4 Low Dose Bisoprolol;High Dose Bisoprolol
17 Clinical Value of Heart Rate Variability Indexes to Predict Outcomes After Exercise Training in Chronic Heart Failure Completed NCT02903225 Phase 4
18 Effects of Dietary Nitrate Supplementation on Cardiorespiratory Control in Chronic Heart Failure Completed NCT02401126 Phase 4
19 A Trial of Thiamin Supplementation in Patients With Heart Failure Completed NCT00959075 Phase 4
20 Supramaximal Titrated Inhibition of RAAS in Dilated Cardiomyopathy Completed NCT01917149 Phase 4 Benazepril;Valsartan;Metoprolol
21 A Study Of The Usage Of Statins In A Community Heart Failure Population Completed NCT00795912 Phase 4 Atorvastatin
22 Evaluation of Heart Failure Treatment Guided by N-terminal Pro B-type Natriuretic Peptide (NTproBNP) vs Clinical Symptoms and Signs Alone Completed NCT00391846 Phase 4 Captopril;Enalapril;Lisinopril;Ramipril;Trandolapril;Bisoprolol;Carvedilol;Metoprolol succinate;Candesartan;Valsartan;Eplerenone;Spironolactone;Diuretics;HF treatment according to Swedish guidelines
23 Efficacy Study of Digoxin & Ivabradine to Treat Heart Failure Completed NCT01699776 Phase 4 Ivabradine;Digoxin
24 Mechanisms of Improvement With Beta-Blocker Treatment in Heart Failure Completed NCT01261065 Phase 4 carvedilol
25 The Purpose of This Study is to Determine if Eplerenone is Effective in Treatment of Mild to Moderate Heart Failure Completed NCT00082589 Phase 4 Eplerenone
26 Treatment of Predominant Central Sleep Apnoea by Adaptive Servo Ventilation in Patients With Heart Failure Completed NCT00733343 Phase 4
27 To Evaluate the Efficacy and Safety on Blood Pressure In Patients With Hypertension Diagnosed Congestive Heart Failure Completed NCT01682564 Phase 4 Candemore tablet;Atacand tablet
28 Monitoring of Hemodynamics in Heart Failure Patients by Intracardiac Impedance Measurement Completed NCT01711281 Phase 4
29 Comparison of AV Optimization Methods Used in Cardiac Resynchronization Therapy (CRT) Completed NCT00677014 Phase 4
30 Effect of Passive Exercise on Systemic Endothelial Function in Elderly Patients With Chronic Heart Failure Completed NCT00733161 Phase 4
31 SIDAMI - Sildenafil and Diastolic Dysfunction After Acute Myocardial Infarction (AMI) Completed NCT01046838 Phase 4 Sildenafil;Placebo
32 A Study of Triple-site Ventricular Pacing in Patients Who Have Not Responded to Conventional Dual Ventricular Site Cardiac Resynchronization Therapy Completed NCT00941850 Phase 4
33 Optimal Programming to Improve Mechanical Indices, Symptoms and Exercise in Cardiac Resynchronization Therapy. Completed NCT00489177 Phase 4
34 Impacts of Aldosterone Blockade on Myocardial Remodeling in Hypertensive Patients With Diastolic Failing Heart Completed NCT01944384 Phase 4 aldactone
35 The TRUST Trial - CardioVascular Imaging ECHO Completed NCT02832960 Phase 4 Levothyroxine;Placebo
36 Trial Assessing the Effect of Preoperative Furosemide on Intraoperative Blood Pressure Completed NCT00115726 Phase 4 furosemide;placebo
37 Effects of Carvedilol on Health Outcomes in Heart Failure Completed NCT00381030 Phase 4 carvedilol plus nurse management
38 Assessment of Hemodynamic Response in Cardiopulmonary Bypass Graft After Cardiopulmonary Bypass Using Transesophegeal Echocardiography Completed NCT01616069 Phase 4 epinephrine and levosimendan
39 Valsartan in Elderly Isolated Systolic Hypertension Study Completed NCT00151229 Phase 4
40 Statin Therapy in Heart Failure: Potential Mechanisms of Benefit Completed NCT00233480 Phase 4 atorvastatin;placebo
41 Association Between Genetic Polymorphism of Beta-adrenergic Receptor and Effects of Bisoprolol in Korean Heart Failure Patients. Completed NCT01104558 Phase 4 Bisoprolol
42 Effects of Nebivolol Versus Carvedilol on Cardiopulmonary Function at High Altitude in Healthy Subjects. Completed NCT00924833 Phase 4 placebo;Carvedilol;Nebivolol
43 Effect of Beta-blockers on Structural Remodeling and Gene Expression in the Failing Human Heart Completed NCT01798992 Phase 4 Carvedilol;Metoprolol succinate;Metoprolol succinate + doxazosin
44 Intravenous Iron in Patients With Systolic Heart Failure and Iron Deficiency to Improve Morbidity & Mortality Recruiting NCT03036462 Phase 4 Iron;Saline
45 Treatment of Diabetes in Patients With Systolic Heart Failure Recruiting NCT02920918 Phase 4 Canagliflozin;Sitagliptin
46 Levothyroxine Replacement for Subclinical Hypothyroidism and Chronic Heart Failure Recruiting NCT03096613 Phase 4 Levothyroxine
47 Exercise Capacity Study of LCZ696 vs. Enalapril in Patients With Chronic Heart Failure and Reduced Ejection Fraction. Recruiting NCT02768298 Phase 4 LCZ696;enalapril;Enalapril matching placebo;LCZ696 matching placebo
48 Dapagliflozin Effect on Symptoms and Biomarkers in Diabetes Patients With Heart Failure Recruiting NCT02653482 Phase 4 Dapagliflozin;Dapagliflozin matching placebo
49 Dapagliflozin in Type 2 Diabetes or Pre-diabetes, and PRESERVED Ejection Fraction Heart Failure Recruiting NCT03030235 Phase 4 Dapagliflozin 10Mg Oral Tablet;Dapagliflozin matching placebo
50 Metformin Pharmacokinetics in Patients With Chronic and Acute Heart Failure Recruiting NCT02797340 Phase 4 Metformin

Search NIH Clinical Center for Systolic Heart Failure

Cochrane evidence based reviews: heart failure, systolic

Genetic Tests for Systolic Heart Failure

Anatomical Context for Systolic Heart Failure

MalaCards organs/tissues related to Systolic Heart Failure:

39
Heart, Kidney, Testes, Brain, Endothelial, Spinal Cord, Bone

Publications for Systolic Heart Failure

Articles related to Systolic Heart Failure:

(show top 50) (show all 634)
id Title Authors Year
1
Determinants of improvement in six-minute walk distance from admission to discharge in acute systolic heart failure: Analysis from the ESCAPE trial. ( 28421593 )
2017
2
Adaptive Servo-Ventilation Treatment Increases Stroke Volume in Stable Systolic Heart Failure Patients With Low Tricuspid Annular Plane Systolic Excursion. ( 28484123 )
2017
3
2D-speckle tracking right ventricular strain to assess right ventricular systolic function in systolic heart failure. Analysis of the right ventricular free and posterolateral walls. ( 28768580 )
2017
4
Referral for Specialist Follow-up and Its Association With Post-discharge Mortality Among Patients With Systolic Heart Failure (from the National Heart Failure Audit for England and Wales). ( 27884420 )
2017
5
The longitudinal relationship between six-minute walk test and cardiopulmonary exercise testing, and association with symptoms in systolic heart failure: Analysis from the ESCAPE trial. ( 28065659 )
2017
6
Can a Left Ventricular Assist Device in Individuals with Advanced Systolic Heart Failure Improve or Reverse Frailty? ( 28940248 )
2017
7
Adherence to systolic heart failure guidelines in ambulatory care in Poland - data from the international QUALIFY survey. ( 28786405 )
2017
8
Prevalence of airflow obstruction in patients with stable systolic heart failure. ( 28061834 )
2017
9
Central Chemoreceptor Sensitivity Is Not Enhanced in Contemporary Patients With Chronic Systolic Heart Failure Receiving Optimal Treatment. ( 27867115 )
2017
10
Improvement of exercise tolerance in cardiopulmonary testing with sustained safety after regular training in outpatients with systolic heart failure (NYHA III) and an implantable cardioverter-defibrillator. Prospective 18-month randomized study. ( 28883851 )
2017
11
Progress in the Presence of Failure: Updates in Chronic Systolic Heart Failure Management. ( 28523441 )
2017
12
Geriatric nutritional risk index as a nutritional and survival risk assessment tool in stable outpatients with systolic heart failure. ( 28438373 )
2017
13
C-reactive protein levels predict systolic heart failure and outcome in patients with first ST-elevation myocardial infarction treated with coronary angioplasty. ( 28883850 )
2017
14
Age and Outcomes of Primary Prevention Implantable Cardioverter Defibrillators in Patients with Non-Ischemic Systolic Heart Failure. ( 28877914 )
2017
15
Prognostic impact of diastolic dysfunction in systolic heart failure-A cross-project analysis from the German Competence Network Heart Failure. ( 28467622 )
2017
16
Galectin-3 and fibulin-1 in systolic heart failure - relation to glucose metabolism and left ventricular contractile reserve. ( 28068900 )
2017
17
Bendopnea and risk of adverse clinical outcomes in ambulatory patients with systolic heart failure. ( 27979033 )
2017
18
Severely Impaired Cardiorespiratory Fitness in Patients With Recently Decompensated Systolic Heart Failure. ( 28867128 )
2017
19
Anxiety and self-care behaviour in patients with chronic systolic heart failure: A multivariate model. ( 28718661 )
2017
20
Ivabradine in Heart Failure: The Representativeness of SHIFT (Systolic Heart Failure Treatment With the IF Inhibitor Ivabradine Trial) in a Broad Population of Patients With Chronic Heart Failure. ( 28903983 )
2017
21
Exploration of flexible phenylpropylurea scaffold as novel cardiac myosin activators for the treatment of systolic heart failure. ( 28432943 )
2017
22
Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease. ( 28709768 )
2017
23
Prognostic potential of midregional pro-adrenomedullin following decompensation for systolic heart failure: comparison with cardiac natriuretic peptides. ( 28516504 )
2017
24
Systematic Evaluation of Endothelin 1 Measurement Relative to Traditional and Modern Biomarkers for Clinical Assessment and Prognosis in Patients With Chronic Systolic Heart Failure: Serial Measurement and Multimarker Testing. ( 28398455 )
2017
25
D-dimer is a predictor of cardiovascular death, and new-onset atrial fibrillation in patients with systolic heart failure. ( 28916077 )
2017
26
The impact of digoxin on mortality in patients with chronic systolic heart failure: A propensity-matched cohort study. ( 27865188 )
2017
27
Screening echocardiograms in a senior focused value based primary care improves systolic heart failure detection and clinical management. ( 28567349 )
2017
28
Clinical Benefits of Stem Cells for Chronic Symptomatic Systolic Heart Failure: A Systematic Review of the Existing Data and Ongoing Trials. ( 27931504 )
2016
29
Impact of aging on cardiac sympathetic innervation measured by (123)I-mIBG imaging in patients with systolic heart failure. ( 27287990 )
2016
30
The effects of ivabradine on left atrial electromechanical function in patients with systolic heart failure. ( 27039084 )
2016
31
Sympathetic nervous system, systolic heart failure, and central sleep apnea: Are we about to find the missing link? ( 27457530 )
2016
32
Characteristics and outcomes of patients with acute systolic heart failure discharged within 48hours: A qualification for "observation status" hospital admission. ( 27537738 )
2016
33
Early improvement of symptoms using LCZ696 in a patient with systolic heart failure and a reduced ejection fraction: a case report. ( 27422865 )
2016
34
Functional characterization of human umbilical cord-derived mesenchymal stem cells for treatment of systolic heart failure. ( 27882158 )
2016
35
Trends in the Use of Guideline-Directed Therapies Among Dialysis Patients Hospitalized With Systolic Heart Failure: Findings From the American Heart Association Get With TheA Guidelines-Heart Failure Program. ( 27179827 )
2016
36
Autoantibodies Specifically Against I^1 Adrenergic Receptors and Adverse Clinical Outcome in Patients With Chronic Systolic Heart Failure in the I^-Blocker Era: The Importance of Immunoglobulin G3 Subclass. ( 26997620 )
2016
37
Furosemide Prescription During the Dry State Is a Predictor of Long-Term Survival of Stable, Optimally Medicated Patients With Systolic Heart Failure. ( 27784799 )
2016
38
Cardiac Myosin Activators in Systolic Heart Failure: More Friend than Foe? ( 27568794 )
2016
39
Variables Measured During Cardiopulmonary Exercise Testing as Predictors of Mortality in Chronic Systolic Heart Failure. ( 26892413 )
2016
40
Positive Impact of Continuous-Flow Left Ventricular Assist Device Implantation on Glycemic Control in Patients with Type 2 Diabetes Mellitus and Advanced Chronic Systolic Heart Failure. ( 27779786 )
2016
41
A functional variant of the neuropeptide S receptor-1 gene modulates clinical outcomes and healthcare utilization in patients with systolic heart failure: results from the Interdisciplinary Network Heart Failure (INH) Study. ( 27990720 )
2016
42
Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure. ( 27571011 )
2016
43
Vitamin D levels predict the response to cardiac resynchronization therapy in patients with systolic heart failure. ( 28045413 )
2016
44
Left ventricular partitioning in systolic heart failure subjects: addressing a mechanistic void with current therapies. ( 27174122 )
2016
45
Could gonadal and adrenal androgen deficiencies contribute to the depressive symptoms in men with systolic heart failure? ( 27650467 )
2016
46
Carotid body resection for sympathetic modulation in systolic heart failure: results from first-in-man study. ( 27647775 )
2016
47
LV mechanical dispersion as a predictor of ventricular arrhythmia in patients with advanced systolic heart failure : A pilot study. ( 26883898 )
2016
48
Echo and natriuretic peptide guided therapy improves outcome and reduces worsening renal function in systolic heart failure: An observational study of 1137 outpatients. ( 27690339 )
2016
49
Exercise Ventilation in COPD: Influence of Systolic Heart Failure. ( 27172093 )
2016
50
Isokinetic Torque Timing Parameters and Ceramides as Markers of Muscle Dysfunction in Systolic Heart Failure. ( 27039968 )
2016

Variations for Systolic Heart Failure

Expression for Systolic Heart Failure

Search GEO for disease gene expression data for Systolic Heart Failure.

Pathways for Systolic Heart Failure

Pathways related to Systolic Heart Failure according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.87 IL6 TNF
2 10.81 IL6 TNF
3 10.73 IL6 TNF
4 10.57 ACE CST3
5 10.3 IL6 TNF
6 10.08 CRP IL6 TNF

GO Terms for Systolic Heart Failure

Cellular components related to Systolic Heart Failure according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 ACE CRP CST3 IL6 NPPB TNF
2 extracellular region GO:0005576 9.17 ACE CORIN CRP CST3 IL6 NPPB

Biological processes related to Systolic Heart Failure according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.54 CRP IL6 TNF
2 positive regulation of chemokine production GO:0032722 9.46 IL6 TNF
3 response to organic cyclic compound GO:0014070 9.43 CST3 IL6
4 defense response to Gram-positive bacterium GO:0050830 9.43 CRP IL6 TNF
5 regulation of blood vessel diameter GO:0097746 9.4 ACE NPPB
6 regulation of blood pressure GO:0008217 9.33 ACE CORIN NPPB
7 neutrophil mediated immunity GO:0002446 9.32 ACE IL6
8 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 8.96 IL6 TNF
9 negative regulation of lipid storage GO:0010888 8.8 CRP IL6 TNF

Sources for Systolic Heart Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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