MCID: SYS003
MIFTS: 44

Systolic Heart Failure

Categories: Cardiovascular diseases

Aliases & Classifications for Systolic Heart Failure

MalaCards integrated aliases for Systolic Heart Failure:

Name: Systolic Heart Failure 12 14
Heart Failure, Systolic 41 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9651
ICD10 32 I50.20
ICD9CM 34 428.2 428.20
MeSH 41 D054143
SNOMED-CT 64 417996009
UMLS 69 C1135191

Summaries for Systolic Heart Failure

MalaCards based summary : Systolic Heart Failure, also known as heart failure, systolic, is related to atrial fibrillation and central sleep apnea. An important gene associated with Systolic Heart Failure is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Dilated cardiomyopathy (DCM) and A-beta Pathways: Plaque Formation and APP Metabolism. The drugs Nitric Oxide and Verapamil have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Systolic Heart Failure

Diseases related to Systolic Heart Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 atrial fibrillation 30.6 ACE ADRB1 NPPB
2 central sleep apnea 30.6 HSPB7 NPPB
3 sleep disorder 30.4 CRP IL6
4 diastolic heart failure 30.3 ACE NPPB
5 kidney disease 30.3 ACE CST3 NPPB
6 apnea, obstructive sleep 30.2 CRP IL6
7 arteries, anomalies of 30.2 ACE CRP IL6 NPPB
8 pulmonary hypertension 30.2 ACE IL6 NPPB
9 sleep apnea 30.1 ACE CRP IL6 NPPB
10 angina pectoris 29.8 ACE CRP IL6
11 intermittent claudication 29.8 ACE CRP IL6
12 pulmonary disease, chronic obstructive 29.7 CRP IL6
13 ischemic heart disease 29.7 ACE CRP IL6 NPPB
14 chagas disease 29.6 ACE ADRB1 IL6 NPPB
15 body mass index quantitative trait locus 11 29.6 ADRB1 CRP IL6 NR3C2
16 chronic kidney failure 29.5 ACE CRP CST3 IL6 NPPB
17 coronary artery anomaly 29.5 ACE ADRB1 CRP IL6 NPPB
18 acute myocardial infarction 29.4 ACE ADRB1 CRP NPPB
19 congestive heart failure 29.2 ACE ADRB1 NPPB NR3C2
20 peripheral artery disease 29.2 ACE CRP CST3 IL6
21 heart disease 28.2 ACE ADRB1 CRP CST3 IL6 NPPB
22 myocardial infarction 28.2 ACE ADRB1 CRP CST3 IL6 NPPB
23 dilated cardiomyopathy 28.2 ACE ADRB1 CRP HSPB7 IL6 NPPB
24 peripartum cardiomyopathy 10.9
25 anterolateral myocardial infarction 10.5 ACE NPPB
26 syndrome of inappropriate antidiuretic hormone 10.5 ACE NPPB
27 aortic valve insufficiency 10.5 ACE NPPB
28 renal hypertension 10.4 ACE NPPB
29 mitral valve insufficiency 10.4 ACE NPPB
30 posterior urethral valves 10.4 ACE IL6
31 hand, foot and mouth disease 10.4 IL6 NPPB
32 chronic thromboembolic pulmonary hypertension 10.4 CRP NPPB
33 anuria 10.4 ACE NR3C2
34 generalized atherosclerosis 10.4 ACE CRP
35 leukomalacia 10.4 IL6 NPPB
36 subdural empyema 10.3 ACE CRP
37 cold agglutinin disease 10.3 CRP IL6
38 diabetic foot ulcers 10.3 CRP IL6
39 cryopyrin-associated periodic syndrome 10.3 CRP IL6
40 neutrophilia, hereditary 10.3 CRP IL6
41 acute cholangitis 10.3 CRP IL6
42 uremic pruritus 10.3 CRP IL6
43 spinal disease 10.3 CRP IL6
44 castleman disease 10.3 CRP IL6
45 viral pneumonia 10.3 CRP IL6
46 cecal disease 10.3 CRP IL6
47 relapsing polychondritis 10.3 CRP IL6
48 central nervous system vasculitis 10.3 CRP IL6
49 subacute thyroiditis 10.3 CRP IL6
50 intussusception 10.3 CRP IL6

Graphical network of the top 20 diseases related to Systolic Heart Failure:



Diseases related to Systolic Heart Failure

Symptoms & Phenotypes for Systolic Heart Failure

MGI Mouse Phenotypes related to Systolic Heart Failure:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 ACE ADRB1 CORIN CRP CST3 IL6
2 homeostasis/metabolism MP:0005376 9.76 ACE ADRB1 CORIN CRP CST3 IL6
3 muscle MP:0005369 9.35 ADRB1 CORIN CST3 IL6 NR3C2
4 renal/urinary system MP:0005367 9.02 NR3C2 ACE CORIN IL6 LGALS3

Drugs & Therapeutics for Systolic Heart Failure

Drugs for Systolic Heart Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 186)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitric Oxide Approved Phase 4 10102-43-9 145068
2
Verapamil Approved Phase 4 52-53-9 2520
3
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
4
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
5
Dobutamine Approved Phase 4 34368-04-2 36811
6
Nitroprusside Approved, Investigational Phase 4 15078-28-1 11963622
7
Iron Approved Phase 4,Phase 2,Phase 3 7439-89-6 23925
8
Benazepril Approved, Investigational Phase 4 86541-75-5 5362124
9
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
10
Bisoprolol Approved Phase 4 66722-44-9 2405
11
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
12
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
13
Ticlopidine Approved Phase 4 55142-85-3 5472
14
Angiotensin II Approved, Investigational Phase 4,Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
15
Metformin Approved Phase 4,Phase 2,Phase 1 657-24-9 4091 14219
16
Enalapril Approved, Vet_approved Phase 4 75847-73-3 40466924 5362032
17
Enalaprilat Approved Phase 4 76420-72-9 6917719
18
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
19
Canagliflozin Approved Phase 4 842133-18-0
20
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
21
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 59-43-8 1130
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 59-30-3 6037
23 tannic acid Approved, Nutraceutical Phase 4
24 calcium channel blockers Phase 4
25 diuretics Phase 4,Phase 3
26
protease inhibitors Phase 4,Phase 2
27 Adrenergic Agents Phase 4,Phase 1
28 Adrenergic Agonists Phase 4
29 Adrenergic alpha-1 Receptor Antagonists Phase 4
30 Adrenergic alpha-Antagonists Phase 4
31 Adrenergic Antagonists Phase 4
32 Adrenergic beta-Agonists Phase 4
33 Sodium Potassium Chloride Symporter Inhibitors Phase 4
34 Adrenergic beta-Antagonists Phase 4,Phase 1
35 Natriuretic Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
36 Neurotransmitter Agents Phase 4,Phase 2
37 Nitric Oxide Donors Phase 4
38 HIV Protease Inhibitors Phase 4,Phase 2
39 Vasodilator Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
40 Hormones Phase 4,Phase 3,Phase 1
41 Angiotensin-Converting Enzyme Inhibitors Phase 4,Phase 2
42 Peripheral Nervous System Agents Phase 4
43 Anti-Arrhythmia Agents Phase 4
44 Antihypertensive Agents Phase 4,Phase 2
45 Protective Agents Phase 4
46 Autonomic Agents Phase 4
47 Calcium, Dietary Phase 4,Phase 3
48 Atorvastatin Calcium Phase 4 134523-03-8
49 Prasugrel hydrochloride Phase 4 389574-19-0
50 Fibrinolytic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 151)

# Name Status NCT ID Phase Drugs
1 Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism Unknown status NCT02316743 Phase 4 Levothyroxine supplementation
2 Carvedilol Versus Verapamil in Chronic Heart Failure Secondary to Non-Ischemic Cardiomyopathy Unknown status NCT00348530 Phase 4 Verapamil
3 Shensong Yangxin Capsule in the Treatment of Heart Failure Complicated With Ventricular Premature Beat Unknown status NCT01612260 Phase 4 Shensong Yangxin capsule;placebo Capsule
4 Danish ICD Study in Patients With Dilated Cardiomyopathy Unknown status NCT00542945 Phase 4
5 Intravenous Vasodilator vs. Inotropic Therapy in Patients With Heart Failure Reduced Ejection Fraction and Acute Decompensation With Low Cardiac Output (PRIORITY-ADHF Study) Unknown status NCT02767024 Phase 4 Sodium nitroprusside;Dobutamine;Furosemide
6 Platelet Inhibition in Patients With Systolic Heart Failure Completed NCT01765400 Phase 4 Prasugrel 10 mg daily x 2 weeks;Clopidogrel 75 mg daily x 2 weeks
7 Medtronic South Asian Systolic Heart Failure Registry Completed NCT01434615 Phase 4
8 A Prospective, Open-labeled, Multi-centric Trial in Subjects With Systolic Heart Failure to Evaluate Bisoprolol Treatment for the Effects on Surrogate Markers of Heart Failure in Korea Completed NCT01074307 Phase 4 Low Dose Bisoprolol;High Dose Bisoprolol
9 Clinical Value of Heart Rate Variability Indexes to Predict Outcomes After Exercise Training in Chronic Heart Failure Completed NCT02903225 Phase 4
10 Effects of Dietary Nitrate Supplementation on Cardiorespiratory Control in Chronic Heart Failure Completed NCT02401126 Phase 4
11 Supramaximal Titrated Inhibition of RAAS in Dilated Cardiomyopathy Completed NCT01917149 Phase 4 Benazepril;Valsartan;Metoprolol
12 A Trial of Thiamin Supplementation in Patients With Heart Failure Completed NCT00959075 Phase 4
13 A Study Of The Usage Of Statins In A Community Heart Failure Population Completed NCT00795912 Phase 4 Atorvastatin
14 Description of Tolerability of LCZ696 (Sacubitril / Valsartan) in Heart Failure With Reduced Ejection Fraction (HFrEF) Treated in Real Life Setting Completed NCT02690974 Phase 4 LCZ696 (sacubitril/valsartan)
15 Intravenous Iron in Patients With Systolic Heart Failure and Iron Deficiency to Improve Morbidity & Mortality Recruiting NCT03036462 Phase 4 Iron;Saline
16 Treatment of Diabetes in Patients With Systolic Heart Failure Recruiting NCT02920918 Phase 4 Canagliflozin;Sitagliptin
17 Thyroid Hormone Replacement for Subclinical Hypothyroidism and Chronic Heart Failure Recruiting NCT03096613 Phase 4 Levothyroxine
18 Exercise Capacity Study of LCZ696 vs. Enalapril in Patients With Chronic Heart Failure and Reduced Ejection Fraction. Recruiting NCT02768298 Phase 4 LCZ696;enalapril;Enalapril matching placebo;LCZ696 matching placebo
19 Metformin Pharmacokinetics in Patients With Chronic and Acute Heart Failure Recruiting NCT02797340 Phase 4 Metformin
20 Inspiratory Muscle Training for Breathless Patients With Chronic Obstructive Pulmonary Disease and Heart Failure Recruiting NCT02579200 Phase 4
21 Pulse Reduction On Beta-blocker and Ivabradine Therapy Recruiting NCT02973594 Phase 4 Ivabradine;Placebo
22 Efficacy of Implantable Cardioverter Defibrillator in Patients With Non-ischemic Systolic Heart Failure on Mortality Active, not recruiting NCT00541268 Phase 4
23 Prophylactic Lisinopril to Prevent Anthracycline Cardiomyopathy. Not yet recruiting NCT03392740 Phase 4 Lisinopril;Placebo Oral Tablet
24 NORDIC: Nitric Oxide-Derived Oxidants and Regional Endothelial and Diastolic Dysfunction in Dilated Cardiomyopathy Terminated NCT00293137 Phase 4
25 Clinical Trial of Systolic Heart Failure Treatment of IvabRadine Hemisulfate Sustained-release Tablets (FIRST) Unknown status NCT02188082 Phase 2, Phase 3 IvabRadine hemisulfate Sustained-release Tablets;placebo
26 Imaging Study of Allocation of Pacing Targets in Cardiac Resynchronization Therapy Unknown status NCT01640769 Phase 3
27 Intracoronary Infusion of BM-Derived Mononuclear Cells in Patients With Large Acute Myocardial Infarction Unknown status NCT00497211 Phase 2, Phase 3
28 Short Term Oral Iron Supplementation in Systolic Heart Failure Patients Suffering From Iron Deficiency Anemia Completed NCT02998697 Phase 2, Phase 3 Ferrous Sulfate;Placebo Oral Capsule
29 Spinal Cord Stimulation For Heart Failure Completed NCT01362725 Phase 2, Phase 3
30 Crestor Versus Placebo in Subjects With Heart Failure Completed NCT00206310 Phase 3 CRESTOR
31 A Comparison Of Outcomes In Patients In New York Heart Association (NYHA) Class II Heart Failure When Treated With Eplerenone Or Placebo In Addition To Standard Heart Failure Medicines Completed NCT00232180 Phase 3 Eplerenone
32 ACCLAIM - Advanced Chronic Heart Failure CLinical Assessment of Immune Modulation Therapy Completed NCT00111969 Phase 3
33 Effects of Ranolazine on Coronary Flow Reserve in Symptomatic Diabetic Patients and CAD Completed NCT01754259 Phase 3 Ranolazine;Placebo
34 A Study Comparing Blood Flow and Clinical and Safety Effects of the Addition of Natrecor (Nesiritide), Placebo or Intravenous Nitroglycerin to Standard Care for the Treatment of Worsening Congestive Heart Failure. Completed NCT00270374 Phase 3 nesiritide
35 Cardiovascular Effects of Preferred Home-based Exercise Training in Systolic Heart Failure Recruiting NCT02051712 Phase 3
36 Safety and Efficacy Study of HGP1207 in Patients With Pulmonary Hypertension Recruiting NCT01913847 Phase 3 Sildenafil;Placebo
37 Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections. Recruiting NCT02809131 Phase 3 polymixin/bacitracin;cephalexin, or levofloxacin, or clindamycin;Saline
38 Renal Artery Denervation in Chronic Heart Failure Study Active, not recruiting NCT01639378 Phase 3
39 Blended Collaborative Care for Heart Failure and Co-Morbid Depression Active, not recruiting NCT02044211 Phase 2, Phase 3
40 Study of the Survival of Recombinant Human Neuregulin-1β in Chronic Heart Failure (CHF) Patients Not yet recruiting NCT03388593 Phase 3 rhNRG-1;Placebo
41 Udenafil Therapy to Improve Symptomatology, Exercise Tolerance and Hemodynamics in Patients With Chronic Systolic Heart Failure Terminated NCT01646515 Phase 3 Placebo;Udenafil (Zydena)
42 Study of Efficacy on Cardiac Remodeling of Recombinant Human Neuregulin-1 in Stable Chronic Systolic Heart Failure Patients Terminated NCT01439893 Phase 3 rhNRG-1;Placebo
43 Clinical Trial to Evaluate the Efficacy and Safety of Recombinant Human Neuregulin-1 for Subcutaneous Administration in Patients With Chronic Systolic Heart Failure Terminated NCT01214096 Phase 3 rhNRG-1;rhNRG-1;rhNRG-1;placebo
44 Study of the Survival of Recombinant Human Neuregulin-1β in Chronic Heart Failure (CHF) Patients Terminated NCT01541202 Phase 3 rhNRG-1;Placebo
45 Study of Efficacy on NT-proBNP of Recombinant Human Neuregulin-1 in Chronic Heart Failure Patients Terminated NCT01439789 Phase 3 rhNRG-1;Placebo
46 Study of the Survival of Recombinant Human Neuregulin-1β in Chronic Heart Failure (CHF) Patients Terminated NCT01131637 Phase 3 rhNRG-1;placebo
47 MADIT ASIA Cardiac Resynchronization Trial Terminated NCT01872234 Phase 3
48 Effects of Aliskiren, Ramipril, and the Combination on Levels of Angiotensin II in Patients With Decompensated Systolic Heart Failure Completed NCT00923156 Phase 2 aliskiren;ramipril;Placebo to aliskiren;Placebo to ramipril
49 Repurposing Probenecid as a Positive Inotrope for the Treatment of Heart Failure Completed NCT01814319 Phase 2 Probenecid 1 gr oral twice daily;Placebo
50 A Dose-Defining Study of CXL-1020 in Patients With Systolic Heart Failure Completed NCT01096043 Phase 2 Placebo;Strata 1 CXL-1020;Strata 2 CXL-1020;Strata 3 CXL-1020

Search NIH Clinical Center for Systolic Heart Failure

Cochrane evidence based reviews: heart failure, systolic

Genetic Tests for Systolic Heart Failure

Anatomical Context for Systolic Heart Failure

MalaCards organs/tissues related to Systolic Heart Failure:

38
Heart, Testes, Brain, Spinal Cord, Endothelial, Kidney, Bone

Publications for Systolic Heart Failure

Articles related to Systolic Heart Failure:

(show top 50) (show all 654)
# Title Authors Year
1
Is There a Sex-Related Difference in the Obesity Paradox in Systolic Heart Failure? Sex-Related Difference in the Obesity Paradox. ( 29214777 )
2018
2
Resistance exercise enhances oxygen uptake without worsening cardiac function in patients with systolic heart failure: a systematic review and meta-analysis. ( 29199385 )
2018
3
Utility of Left Atrial Expansion Index and Stroke Volume in Management of Chronic Systolic Heart Failure. ( 29426648 )
2018
4
Systolic heart failure after liver transplantation: Incidence, predictors, and outcome. ( 29323769 )
2018
5
Effect of Early Treatment With Ivabradine Plus Beta-blockers on Long-term Outcomes in Patients Hospitalized With Systolic Heart Failure. ( 29373253 )
2018
6
Contractile reserve as a predictor of prognosis in patients with non-ischaemic systolic heart failure and dilated cardiomyopathy: a systematic review and meta-analysis. ( 29258998 )
2018
7
Contractile reserve as a predictor of prognosis in non-ischaemic systolic heart failure: a systematic review and meta-analysis. ( 29203463 )
2017
8
Age and Outcomes of Primary Prevention Implantable Cardioverter Defibrillators in Patients with Non-Ischemic Systolic Heart Failure. ( 28877914 )
2017
9
Adaptive servo-ventilation for central sleep apnoea in systolic heart failure: results of the major substudy of SERVE-HF. ( 29193576 )
2017
10
Central Chemoreceptor Sensitivity Is Not Enhanced in Contemporary Patients With Chronic Systolic Heart Failure Receiving Optimal Treatment. ( 27867115 )
2017
11
Prognostic impact of diastolic dysfunction in systolic heart failure-A cross-project analysis from the German Competence Network Heart Failure. ( 28467622 )
2017
12
The longitudinal relationship between six-minute walk test and cardiopulmonary exercise testing, and association with symptoms in systolic heart failure: Analysis from the ESCAPE trial. ( 28065659 )
2017
13
Prognostic value of real-time three-dimensional echocardiography compared to two-dimensional echocardiography in patients with systolic heart failure. ( 29098525 )
2017
14
Bendopnea and risk of adverse clinical outcomes in ambulatory patients with systolic heart failure. ( 27979033 )
2017
15
Prevalence of airflow obstruction in patients with stable systolic heart failure. ( 28061834 )
2017
16
Can a Left Ventricular Assist Device in Individuals with Advanced Systolic Heart Failure Improve or Reverse Frailty? ( 28940248 )
2017
17
Adherence to systolic heart failure guidelines in ambulatory care in Poland - data from the international QUALIFY survey. ( 28786405 )
2017
18
Galectin-3 and fibulin-1 in systolic heart failure - relation to glucose metabolism and left ventricular contractile reserve. ( 28068900 )
2017
19
Adaptive Servo-Ventilation Treatment Increases Stroke Volume in Stable Systolic Heart Failure Patients With Low Tricuspid Annular Plane Systolic Excursion. ( 28484123 )
2017
20
D-dimer is a predictor of cardiovascular death, and new-onset atrial fibrillation in patients with systolic heart failure. ( 28916077 )
2017
21
Geriatric nutritional risk index as a nutritional and survival risk assessment tool in stable outpatients with systolic heart failure. ( 28438373 )
2017
22
Dissociation of Objective and Subjective Daytime Sleepiness and Biomarkers of Systemic Inflammation in Sleep-Disordered Breathing and Systolic Heart Failure. ( 29065958 )
2017
23
Myocardial perfusion in patients with non-ischaemic systolic heart failure and type 2 diabetes: a cross-sectional study using Rubidium-82 PET/CT. ( 29285726 )
2017
24
Improvement of exercise tolerance in cardiopulmonary testing with sustained safety after regular training in outpatients with systolic heart failure (NYHA III) and an implantable cardioverter-defibrillator. Prospective 18-month randomized study. ( 28883851 )
2017
25
Acute Effects of Positive Airway Pressure on Functional Mitral Regurgitation in Patients with Systolic Heart Failure. ( 29218014 )
2017
26
Mortality prediction using CHADS2/CHA2DS2-VASc/R2CHADS2 scores in systolic heart failure patients with or without atrial fibrillation. ( 29069008 )
2017
27
Referral for Specialist Follow-up and Its Association With Post-discharge Mortality Among Patients With Systolic Heart Failure (from the National Heart Failure Audit for England and Wales). ( 27884420 )
2017
28
The impact of digoxin on mortality in patients with chronic systolic heart failure: A propensity-matched cohort study. ( 27865188 )
2017
29
Basic research: Inhibition of Hippo pathway signalling reverses systolic heart failure. ( 29053154 )
2017
30
Exploration of flexible phenylpropylurea scaffold as novel cardiac myosin activators for the treatment of systolic heart failure. ( 28432943 )
2017
31
2D-speckle tracking right ventricular strain to assess right ventricular systolic function in systolic heart failure. Analysis of the right ventricular free and posterolateral walls. ( 28768580 )
2017
32
Influence of renal impairment on aldosterone status, calcium metabolism, and vasopressin activity in outpatients with systolic heart failure. ( 29154425 )
2017
33
Ivabradine - well tolerated in elderly patients with systolic heart failure. ( 29121737 )
2017
34
Systematic Evaluation of Endothelin 1 Measurement Relative to Traditional and Modern Biomarkers for Clinical Assessment and Prognosis in Patients With Chronic Systolic Heart Failure: Serial Measurement and Multimarker Testing. ( 28398455 )
2017
35
Prognostic potential of midregional pro-adrenomedullin following decompensation for systolic heart failure: comparison with cardiac natriuretic peptides. ( 28516504 )
2017
36
The Impact of Bronchodilator Therapy on Systolic Heart Failure with Concomitant Mild to Moderate COPD. ( 29283405 )
2017
37
Progress in the Presence of Failure: Updates in Chronic Systolic Heart Failure Management. ( 28523441 )
2017
38
C-reactive protein levels predict systolic heart failure and outcome in patients with first ST-elevation myocardial infarction treated with coronary angioplasty. ( 28883850 )
2017
39
Determinants of improvement in six-minute walk distance from admission to discharge in acute systolic heart failure: Analysis from the ESCAPE trial. ( 28421593 )
2017
40
Anxiety and self-care behaviour in patients with chronic systolic heart failure: A multivariate model. ( 28718661 )
2017
41
Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease. ( 28709768 )
2017
42
Global longitudinal strain corrected by RR interval is a superior predictor of all-cause mortality in patients with systolic heart failure and atrial fibrillation. ( 29024533 )
2017
43
Ivabradine in Heart Failure: The Representativeness of SHIFT (Systolic Heart Failure Treatment With the IF Inhibitor Ivabradine Trial) in a Broad Population of Patients With Chronic Heart Failure. ( 28903983 )
2017
44
Severely Impaired Cardiorespiratory Fitness in Patients With Recently Decompensated Systolic Heart Failure. ( 28867128 )
2017
45
Screening echocardiograms in a senior focused value based primary care improves systolic heart failure detection and clinical management. ( 28567349 )
2017
46
Mobitz Type II Atrioventricular Block following Tramadol and Fentanyl in a Patient with Acute Coronary Syndrome and Systolic Heart Failure. ( 29184615 )
2017
47
Interleukin-1 Blockade in Recently Decompensated Systolic Heart Failure: Results From REDHART (Recently Decompensated Heart Failure Anakinra Response Trial). ( 29141858 )
2017
48
Echo and natriuretic peptide guided therapy improves outcome and reduces worsening renal function in systolic heart failure: An observational study of 1137 outpatients. ( 27690339 )
2016
49
Vitamin D levels predict the response to cardiac resynchronization therapy in patients with systolic heart failure. ( 28045413 )
2016
50
Acute systolic heart failure and uncontrolled hypertension: what is the missing link? ( 27455906 )
2016

Variations for Systolic Heart Failure

Expression for Systolic Heart Failure

Search GEO for disease gene expression data for Systolic Heart Failure.

Pathways for Systolic Heart Failure

Pathways related to Systolic Heart Failure according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.57 ACE ADRB1 IL6
2 10.32 ACE CST3
3 9.9 CRP IL6

GO Terms for Systolic Heart Failure

Cellular components related to Systolic Heart Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 ACE CRP CST3 IL6 LGALS3 NPPB
2 extracellular region GO:0005576 9.17 ACE CORIN CRP CST3 IL6 LGALS3

Biological processes related to Systolic Heart Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 monocyte chemotaxis GO:0002548 9.37 IL6 LGALS3
2 acute-phase response GO:0006953 9.32 CRP IL6
3 regulation of blood vessel diameter GO:0097746 9.26 ACE NPPB
4 neutrophil mediated immunity GO:0002446 9.16 ACE IL6
5 negative regulation of lipid storage GO:0010888 8.96 CRP IL6
6 regulation of blood pressure GO:0008217 8.8 ACE CORIN NPPB

Sources for Systolic Heart Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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