MCID: TCL003
MIFTS: 51

T Cell Deficiency malady

Immune category

Summaries for T Cell Deficiency

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 T cell deficiency is a deficiency of T cells, either caused by lymphocytopenia of T cells or by... more...

MalaCards: T Cell Deficiency, also known as t-lymphocyte deficiency, is related to autoimmune hemolytic anemia and thyroiditis. An important gene associated with T Cell Deficiency is IGLL1 (immunoglobulin lambda-like polypeptide 1), and among its related pathways are Akt Signaling and TGF-Beta Pathway. The compounds histamine and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for T Cell Deficiency

Sources:
61UMLS, 8Disease Ontology, 10DISEASES, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune


Aliases & Descriptions:

t cell deficiency 8 10
t-lymphocyte deficiency 61


External Ids:

Disease Ontology8 DOID:11200
NCIt40 C27872

Related Diseases for T Cell Deficiency

Sources:
17GeneCards, 18GeneDecks
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Diseases related to T Cell Deficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 200)
idRelated DiseaseScoreTop Affiliating Genes
1autoimmune hemolytic anemia30.2CD79A
2thyroiditis30.1CD79A
3graves' disease30.1IL4, ICAM1
4omenn syndrome30.0IL5, IGHE, IL4
5vasculitis30.0CD79A, ICAM1
6tuberculosis30.0CD79A, IL4, CCL7
7arthritis30.0IL4, ICAM1
8cryoglobulinemia30.0CD79A
9alopecia areata30.0ICAM1
10hepatitis b30.0CD79A
11systemic lupus erythematosus30.0IL4, CD79A, ICAM1, TNFRSF13C
12t lymphocyte deficiency10.6
13b cell deficiency10.5
14graft versus host disease10.2
15hepatitis c10.2
16common variable immunodeficiency10.2
17hepatitis d10.2
18progressive multifocal leukoencephalopathy10.2
19nezelof syndrome10.2
20immune defect due to absence of thymus10.2
21deficiency anemia10.1
22ataxia telangiectasia10.1
23digeorge syndrome10.1
24n syndrome10.1
25vaccinia10.1
26molluscum contagiosum10.0
27chronic granulomatous disease10.0
28hypoparathyroidism10.0
29lissencephaly10.0
30adult t-cell leukemia10.0
31immune-complex glomerulonephritis10.0
32cd3zeta deficiency10.0
33cd45 deficiency10.0
34gamma chain deficiency10.0
35reticular dysgenesis10.0
36lepromatous leprosy10.0
37thymic dysplasia10.0
38glucose intolerance10.0
39chronic mucocutaneous candidiasis10.0
40listeriosis10.0
41adenosine deaminase deficiency10.0
42fabry disease10.0
43adult-onset still's disease10.0
44sclerosing cholangitis10.0
45protein c deficiency10.0
46alopecia10.0
47t-cell leukemia10.0
48turner syndrome10.0
49charge syndrome10.0
50char syndrome10.0

Graphical network of the top 20 diseases related to T Cell Deficiency:



Diseases related to t cell deficiency

Clinical Features for T Cell Deficiency

Drugs & Therapeutics for T Cell Deficiency

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for T Cell Deficiency

Drug clinical trials:

Search ClinicalTrials for T Cell Deficiency

Search NIH Clinical Center for T Cell Deficiency

Search CenterWatch for T Cell Deficiency

Genetic Tests for T Cell Deficiency

Anatomical Context for T Cell Deficiency

Sources:
33MalaCards
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MalaCards organs/tissues related to T Cell Deficiency:

33
Skin, Ovary, Liver, Brain, Kidney, Lung, Spleen, Bone marrow, Whole blood, Thymus, Heart, Skeletal muscle, Small intestine, Colon, Thyroid, Breast, Prostate, Testis, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Bronchial epithelium, Pancreatic islet, Pituitary, Testis germ, Testis leydig

Animal Models for T Cell Deficiency or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for T Cell Deficiency

Sources:
51PubMed
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Articles related to T Cell Deficiency:

(show top 50)    (show all 489)
idTitleAuthorsYear
1
Plasma Polymer-Coated Contact Lenses for the Culture and Transfer of Corneal Epithelial Cells in the Treatment of Limbal Stem Cell Deficiency. (24328453)
2014
2
Cernunnos deficiency reduces thymocyte life span and alters the T cell repertoire in mice and humans. (23207905)
2013
3
Deficiency of I^-arrestin1 ameliorates collagen-induced arthritis with impaired TH17 cell differentiation. (23589893)
2013
4
Prevalence of high blood pressure, heart disease, thalassemia, sickle-cell anemia, and iron-deficiency anemia among the UAE adolescent population. (23606864)
2013
5
Carabin deficiency in B cells increases BCR-TLR9 costimulation-induced autoimmunity. (23109291)
2012
6
Prevalence of glucose-6-phosphate dehydrogenase deficiency and sickle cell trait among blood donors in Riyadh. (20376264)
2010
7
Expression of membrane-associated mucins in limbal stem cell deficiency and after transplantation of cultivated limbal epithelium. (19274530)
2009
8
Deficiency of GMDS leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling. (19361506)
2009
9
Sickle cell haemoglobin, thalassaemia and G-6-PD enzyme deficiency genes in Garasiya tribe inhabited malaria endemic areas of Sirohi District, Rajasthan (India). (19886170)
2009
10
Effect of iron deficiency anemia and its treatment on cell mediated immunity. (23100979)
2009
11
Red cell distribution width in iron deficiency anemia and beta-thalassemia minor. (18697290)
2008
12
Ammonium alters creatine transport and synthesis in a 3D culture of developing brain cells, resulting in secondary cerebral creatine deficiency. (18380667)
2008
13
Human epidermal Langerhans cells express the tight junction protein claudin-1 and are present in human genetic claudin-1 deficiency (NISCH syndrome). (18095941)
2008
14
p53 (TRP53) deficiency-mediated antiapoptosis escape after 5 Gy X irradiation still induces stem cell leukemia in C3H/He mice: comparison between whole-body assay and bone marrow transplantation (BMT) assay. (17523849)
2007
15
Transgenic rescue of hemolytic anemia due to red blood cell pyruvate kinase deficiency. (17550844)
2007
16
Ornithine transcarbamylase and arginase I deficiency are responsible for diminished urea cycle function in the human hepatoblastoma cell line HepG2. (17098461)
2007
17
Successful HLA-identical hematopoietic stem cell transplantation in a patient with purine nucleoside phosphorylase deficiency. (17910661)
2007
18
Neonatal screening of hemoglobinopathies and G6PD deficiency in Catalonia (Spain). Molecular study of sickle cell disease associated with alpha thalassemia and G6PD deficiency]. (17669331)
2007
19
Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression. (17068332)
2006
20
Riboflavin deficiency causes protein and DNA damage in HepG2 cells, triggering arrest in G1 phase of the cell cycle. (16109485)
2006
21
Survival analysis of conjunctival limbal grafts and amniotic membrane transplantation in eyes with total limbal stem cell deficiency. (16086951)
2005
22
Telomerase RNA deficiency in peripheral blood mononuclear cells in X-linked dyskeratosis congenita. (15349768)
2004
23
T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions. (15141078)
2004
24
IL-23 and IFN-gamma deficiency in immunodeficient HIV patients who achieved a long-term increase in CD4 T-cell counts on highly active antiretroviral therapy. (15362668)
2004
25
Acquired factor VII deficiency in hematopoietic stem cell transplant recipients. (11919730)
2002
26
Activation of caspases and cleavage of Bid are required for tyrosine and phenylalanine deficiency-induced apoptosis of human A375 melanoma cells. (12061801)
2002
27
Inferior vena caval thrombosis with sickle cell disease and heterozygous protein s deficiency. (12218606)
2002
28
Specific amino acid deficiency alters the expression of genes in human melanoma and other tumor cell lines. (11694646)
2001
29
Osteopontin deficiency reduces experimental tumor cell metastasis to bone and soft tissues. (11315992)
2001
30
Molecular studies and NK cell function of a new case of TAP2 homozygous human deficiency. (11529920)
2001
31
Selective T-cell deficiency in Turner's syndrome. (11108446)
2000
32
Apoptosis-resistant T cells have a deficiency in NF-kappaB-mediated induction of Fas ligand transcription. (10092076)
1999
33
Allo-limbal transplantation in patients with limbal stem cell deficiency. (10434862)
1999
34
An Arabidopsis thaliana cDNA complements the N-acetylglucosaminyltransferase I deficiency of CHO Lec1 cells. (10441510)
1999
35
Zinc deficiency and cell-mediated and humoral autoimmunity of insulin-dependent diabetes in thalassemic subjects. (10091178)
1998
36
HB H disease with homozygosity for red cell G6PD deficiency in a Turkish female. (9576333)
1998
37
Molecular pathogenesis of type I congenital plasminogen deficiency: expression of recombinant human mutant plasminogens in mammalian cells. (8978291)
1997
38
Defect of thymocyte emigration in a T cell deficiency strain (CTS) of the mouse. (8871639)
1996
39
5'-Deoxy-5'-methylthioadenosine phosphorylase and p16INK4 deficiency in multiple tumor cell lines. (7898924)
1995
40
Effects of thymidine kinase and methyltransferase deficiency on mutagenesis in a human lymphoblastoid cell line. (7520981)
1994
41
Resistance of HER2/neu-overexpressing tumor targets to lymphokine-activated-killer-cell-mediated lysis: evidence for deficiency of binding and post-binding events. (8097427)
1993
42
Orchitis and human immunodeficiency virus type 1 infected cells in reproductive tissues from men with the acquired immune deficiency syndrome. (1853930)
1991
43
Immunomodulation of T cell deficiency in humans by thymic humoral factor: from crude extract to synthetic thymic humoral factor-gamma 2. (2199613)
1990
44
Mechanisms of 2'-deoxyguanosine toxicity in mouse T-lymphoma cells with purine nucleoside phosphorylase deficiency and resistance to inhibition of ribonucleotide reductase by dGTP. (2114100)
1990
45
Sickle cell hemoglobin, beta-thalassemia and G6PD deficiency in tribes of Maharashtra, India. (2129613)
1990
46
Progenitor cell defect correctable by bone marrow transplantation in five independent mouse models of platelet storage pool deficiency. (3516713)
1986
47
HLA typing of amniotic fluid cells for the prenatal determination of therapeutic transplantation options for a fetus affected with adenosine deaminase deficiency. (6351373)
1983
48
Trehalase deficiency. Prevalence and relation to single-cell protein food. (7137952)
1982
49
Deficiency of T helper cells in transient hypogammaglobulinemia of infancy. (6270560)
1981
50
Effect of riboflavin treatment on human red cell pyruvate kinase deficiency. (963898)
1976

Genetic Variations for T Cell Deficiency

Expression for genes affiliated with T Cell Deficiency

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with T Cell Deficiency

Search GEO for disease gene expression data for T Cell Deficiency.

Pathways for genes affiliated with T Cell Deficiency

Sources:
52QIAGEN, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 4Cell Signaling Technology, 54Reactome, 53R&D Systems
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Pathways related to T Cell Deficiency according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5TEC, IL5, CCL7, TNFRSF13C, BTK, IL4
2
Hide members
10.5IL5, BTK, TNFRSF13C, IL4, CCL7
3
Hide members
10.5IL5, BTK, TNFRSF13C, CCL7, IL4
410.5CD79A, BTK, IGLL1, TNFRSF13C
5
Hide members
10.5ICAM1, IGHE, BTK, CD79A, IL5, IL4
6
Hide members
10.5IL4, ICAM1, TNFRSF13C, IL5
7
Hide members
10.5TEC, IL5, CD79A, BTK, IL4
810.5BTK, ICAM1, TNFRSF13C
910.5IL5, BTK, ICAM1
1010.5ICAM1, SFN, IL4, IL5
11
Hide members
10.5CD79A, TEC, BTK, IL4
1210.5IL4, CD79A, BTK, TEC
13
Hide members
10.5TEC, CD79A, BTK, IGHE
14
Immune response NFAT in immune response
Hide members
10.5CD79A, BTK, IGHE
1510.5IL5, IL4, IGHE
1610.5IL5, IL4

Compounds for genes affiliated with T Cell Deficiency

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience
See all sources

Compounds related to T Cell Deficiency according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1histamine45 29 2413.0MUC5AC, ICAM1, CCL7, BTK, IGHE, CD79A
2retinoic acid45 2412.0ICAM1, KRT13, KRT19, IL5, CD79A, MUC4
3dexamethasone45 50 29 1114.0CCL7, MUC5AC, IGHE, MUC4, CD79A, IL5
4tarc4511.0IGHE, CCL7, IL5, IL4, ICAM1
5paraffin4511.0TP63, KRT19, IL5, MUC5AC, KRT13, CD79A
6methacholine45 1112.0IL5, IL4, CD79A, ICAM1, IGHE
7tyrosine4511.0ICAM1, KRT19, TP63, CCL7, MUC5AC, MUC4
8sodium cromoglycate4511.0CD79A, IL5, ICAM1, IGHE
9allergens4511.0SCP2, IL5, IL4, CD79A, IGHE
10nedocromil sodium4511.0ICAM1, IL5, IL4, IGHE
11praziquantel45 1111.9IGHE, CD79A, IL4, IL5
12azelastine45 1111.9ICAM1, IGHE, IL4, IL5
13ivig4510.9BTK, CD79A, IGHE
14testosterone45 60 11 2413.9IGHE, IL5, MUC5AC, CD79A, KRT19, SCP2
15unicap4510.9IL5, CD79A, IGHE
16budesonide45 50 1112.9ICAM1, IL5, IL4, IGHE
17omalizumab45 1111.9IL5, IGHE, IL4
18oxatomide4510.9IL5, IGHE, ICAM1
19calcium45 50 11 2413.9CCL7, SFN, TNFRSF13C, MUC5AC, TP63, TEC
20arginine4510.9IL4, IL5, CD79A, BTK, IGHE, TP63
21cyclosporin a45 29 6012.9ICAM1, TEC, IL4, IL5, CD79A, IGHE
22toluene diisocyanate4510.9IGHE, KRT19, IL5
23desloratadine45 1111.9IL4, IGHE, ICAM1
24ovomucoid4510.9IGHE
25cetirizine45 29 11 2413.9ICAM1, IGHE, IL5
26vegf4510.9TP63, KRT19, IL5, CD79A
27ketotifen45 1111.9ICAM1, IGHE, IL5
28penicillin4510.9CD79A, IGHE, IL5
29n acetylcysteine4510.9MUC5AC, IGHE, ICAM1, CD79A, IL4
30sb 20358045 6011.9ICAM1, IL5, IL4, BTK, MUC5AC
31itraconazole45 1111.9IL5, IL4, IGHE
32cycloheximide4510.8KRT19, IL4, IL5, CCL7, IGHE, ICAM1
33montelukast45 50 29 1113.8IL4, IGHE, IL5
34fibrinogen4510.8CD79A, BTK, ICAM1, TEC, KRT19
35okt34510.8ICAM1, CD79A, IL4
36loteprednol45 1111.8IL4, IL5
37tolnaftate4510.8IL4, IL5
38con a4510.8CD79A, IL5, IL4
39gm-csf45 2911.8IL4, IL5, ICAM1
40bromodeoxyuridine4510.8KRT3, KRT19, BTK, TP63
41salbutamol45 50 29 11 2414.7CD79A, IL5, IGHE
42fluticasone propionate45 50 60 1113.7IGHE, IL5, IL4
43thyroxine45 2411.7IGHE, IL5, CD79A, IL4
44steroid4510.7SCP2, MUC5AC, TP63, KRT19, MUC4, CD79A
45mometasone45 1111.6IL5, IL4
46proline4510.6KRT3, TEC, KRT13, BTK, MUC5AC
47phosphatidylinositol4510.5ICAM1, MUC4, SCP2, TEC, MUC5AC, BTK
48levocabastine45 29 1112.5ICAM1, IL5
49carbamazepine45 50 1112.4CD79A, IL5, IL4
50methotrexate45 50 1112.2CD79A, IGHE, IL5, MUC5AC

GO Terms for genes affiliated with T Cell Deficiency

Sources:
16Gene Ontology
See all sources

Cellular components related to T Cell Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.5IL4, CD79A, TNFRSF13C, ICAM1

Biological processes related to T Cell Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell receptor signaling pathwayGO:05085310.6TEC, CD79A, BTK
2positive regulation of B cell proliferationGO:03089010.5IL4, IL5, TNFRSF13C
3keratinocyte proliferationGO:04361610.5TP63, SFN
4B cell costimulationGO:03129610.4TNFRSF13C, IL4
5immune responseGO:00695510.2IL4, IL5, IGLL1, IGHE, CCL7

Products for genes affiliated with T Cell Deficiency

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for T Cell Deficiency

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet