MCID: TCL003
MIFTS: 43

T Cell Deficiency malady

Immune diseases category

Summaries for T Cell Deficiency

About this section


Wikipedia:65 T cell deficiency is a deficiency of T cells, either caused by lymphocytopenia of T cells or by... more...

MalaCards based summary: T Cell Deficiency, also known as t-lymphocyte deficiency, is related to severe combined immunodeficiency and systemic lupus erythematosus. An important gene associated with T Cell Deficiency is SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1), and among its related pathways are ICos-ICosL Pathway in T-Helper Cell and Lymphocyte Signaling. The compounds ctla4-ig and c-d4t have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for T Cell Deficiency

About this section

T Cell Deficiency, Aliases & Descriptions:

Name: T Cell Deficiency 10 12
 
T-Lymphocyte Deficiency 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


External Ids:

Disease Ontology10 DOID:11200
NCIt40 C27872

Related Diseases for T Cell Deficiency

About this section

Diseases related to T Cell Deficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1severe combined immunodeficiency30.3IL15, IL2, PTPRC
2systemic lupus erythematosus30.2PTPRC, IL2, IL15
3hepatitis c30.0IL2, PTPRC
4nephrotic syndrome30.0SMARCAL1, PTPRC
5t-cell leukemia29.9IL2, PTPRC
6leukemia29.9IL15, IL2, PTPRC
7common variable immunodeficiency10.2
8hepatitis10.2
9tcr-alpha-beta-positive t-cell deficiency10.2
10ataxia-telangiectasia10.1
11digeorge syndrome10.1
12obesity10.1
13hemolytic anemia10.1
14autoimmune hemolytic anemia10.1
15lupus erythematosus10.1
16hyper ige syndrome10.1
17tropical spastic paraparesis10.0IL15, IL2
18sezary's disease10.0IL15, IL2
19acute graft versus host disease10.0IL15, IL2
20severe combined immunodeficiency, x-linked10.0IL15, IL2
21mycosis fungoides10.0IL2, IL15
22myasthenia gravis10.0IL15, IL2
23lymphopenia10.0IL15, IL2
24cutaneous t cell lymphoma10.0IL2, IL15
25graft-versus-host disease, protection against10.0IL15, IL2
26hcl-v10.0IL2, PTPRC
27thymoma10.0IL2, PTPRC
28fibrosarcoma10.0IL15, IL2
29precursor t-cell acute lymphoblastic leukemia10.0PTPRC, IL2
30rhabdomyosarcoma10.0IL15, PTPRC
31hodgkin lymphoma10.0IL2, PTPRC
32chronic lymphocytic leukemia10.0IL2, PTPRC
33schizophrenia10.0
34reticular dysgenesis10.0
35hypoparathyroidism-retardation-dysmorphism syndrome10.0
36charge syndrome10.0
37t-cell immunodeficiency, congenital alopecia, and nail dystrophy10.0
38vici syndrome10.0
39fabry disease10.0
40lymphoproliferative syndrome, x-linked, 110.0
41leprosy10.0
42schimke immunoosseous dysplasia10.0
43adult t-cell leukemia10.0
44alopecia10.0
45arthritis10.0
46brain injury10.0
47cataract10.0
48chronic granulomatous disease10.0
49ectodermal dysplasia10.0
50glomerulonephritis10.0

Graphical network of the top 20 diseases related to T Cell Deficiency:



Diseases related to t cell deficiency

Symptoms for T Cell Deficiency

About this section

Drugs & Therapeutics for T Cell Deficiency

About this section

Drug clinical trials:

Search ClinicalTrials for T Cell Deficiency

Search NIH Clinical Center for T Cell Deficiency

Genetic Tests for T Cell Deficiency

About this section

Anatomical Context for T Cell Deficiency

About this section

MalaCards organs/tissues related to T Cell Deficiency:

33
T cells, B cells, Bone, Bone marrow, Thymus, Neutrophil, Liver, Lymph node, Spleen, Brain, Heart, Skeletal muscle, Small intestine, Kidney, Lung, Skin, Testes

Animal Models for T Cell Deficiency or affiliated genes

About this section

MGI Mouse Phenotypes related to T Cell Deficiency:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.1SMARCAL1, PTPRC, IL2, IL15, HNRNPLL, ZBTB1
2MP:00053976.8HNRNPLL, IL15, IL2, PTPRC, SMARCAL1, ZBTB1

Publications for T Cell Deficiency

About this section

Articles related to T Cell Deficiency:

(show top 50)    (show all 112)
idTitleAuthorsYear
1
Invariant natural killer T cell deficiency leads to the development of spontaneous liver inflammation dependent on I^I'T cells in mice. (25791517)
2015
2
Attenuated adipose tissue and skeletal muscle inflammation in obese mice with combined CD4+ and CD8+ T cell deficiency. (24530773)
2014
3
Mucosal-associated invariant T cell deficiency in systemic lupus erythematosus. (25225673)
2014
4
Impaired spatial memory in mice lacking CD3IP is associated with altered NMDA and AMPA receptors signaling independent of T-cell deficiency. (24259588)
2013
5
The protective effects of T cell deficiency against brain injury are ischemic model-dependent in rats. (23228347)
2013
6
Combined B- and T-cell deficiency does not protect against obesity-induced glucose intolerance and inflammation. (23478176)
2013
7
Fine-tuning of regulatory T cell function: the role of calcium signals and naive regulatory T cells for regulatory T cell deficiency in multiple sclerosis. (23576680)
2013
8
CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis. (22312480)
2012
9
Natural killer T cell deficiency in active adult-onset Still's Disease: correlation of deficiency of natural killer T cells with dysfunction of natural killer cells. (22605480)
2012
10
Enzyme replacement therapy partially prevents invariant Natural Killer T cell deficiency in the Fabry disease mouse model. (22425450)
2012
11
T cell deficiency does not reduce lesions in mice produced by intracerebral injection of NMO-IgG and complement. (21492943)
2011
12
CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells. (22006994)
2011
13
Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses. (20548030)
2010
14
A multiplex immunoassay using the Guthrie specimen to detect T-cell deficiencies including severe combined immunodeficiency disease. (20660143)
2010
15
Lung metastasis fails in MMTV-PyMT oncomice lacking S100A4 due to a T-cell deficiency in primary tumors. (20103644)
2010
16
Profound invariant natural killer T-cell deficiency in inflammatory arthritis. (20444757)
2010
17
Functional T-cell deficiency in adolescents who experience serogroup C meningococcal disease despite receiving the meningococcal serogroup C conjugate vaccine. (20463106)
2010
18
Common variable immunodeficiency with regulatory T-cell deficiency treated with rapamycin. (19230472)
2009
19
Invariant natural killer (iNK) T cell deficiency in patients with common variable immunodeficiency. (19664144)
2009
20
The effects of T cell deficiency on the development of worms and granuloma formation in mice infected with Schistosoma japonicum. (18246371)
2008
21
Generating functional CD8+ T cell memory response under transient CD4+ T cell deficiency: implications for vaccination of immunocompromised individuals. (18506880)
2008
22
NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis. (17082625)
2006
23
Long-lasting CD3+ T-cell deficiency after cord blood stem cell transplantation in a human herpesvirus 6-infected child. (15815044)
2005
24
Responses against complex antigens in various models of CD4 T-cell deficiency: surprises from an anti-CD4 antibody transgenic mouse. (15258307)
2004
25
Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding. (15153499)
2004
26
T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions. (15141078)
2004
27
Reduced expression of Bcl-2 in CD8+ T cells deficient in the IL-15 receptor alpha-chain. (11777964)
2002
28
Genesis of progressive T-cell deficiency owing to a single missense mutation in the common gamma chain gene. (11902333)
2001
29
Genetic control of peripheral T-cell deficiency in the cataract Shionogi (CTS) mouse linked to chromosome 7. (9435347)
1998
30
Clonal expansion of Vgamma3/Vdelta3-expressing gammadelta T cells in an HIV-1/2-negative patient with CD4 T-cell deficiency. (9029011)
1997
31
Association between alphabetaTCR+CD4-CD8- T-cell deficiency and IDDM in NOD/Lt mice. (9075796)
1997
32
Phenotypic features of selective T cell deficiency characterized by absence of CD8+ T lymphocytes and undetectable mRNA for ZAP-70 kinase. (9245543)
1997
33
Defect of thymocyte emigration in a T cell deficiency strain (CTS) of the mouse. (8871639)
1996
34
Detection of a human intracisternal retroviral particle associated with CD4+ T-cell deficiency. (1380169)
1992
35
Immunomodulation of T cell deficiency in humans by thymic humoral factor: from crude extract to synthetic thymic humoral factor-gamma 2. (2199613)
1990
36
Lissencephaly, abnormal lymph nodes, and T-cell deficiency in one patient. (2596499)
1989
37
Mechanisms of Mycobacterium leprae-specific T-cell deficiency in lepromatous leprosy. (3147697)
1988
38
Natural killer cell and cytotoxic/suppressor T cell deficiency in peripheral blood in subjects with alopecia areata. (3250436)
1988
39
Development of immunity in human severe primary T cell deficiency following haploidentical bone marrow stem cell transplantation. (2869085)
1986
40
Reconstitution of T-cell deficiency by thymic hormone or thymus transplantation therapy. (3521966)
1986
41
Models of T cell deficiency in listeriosis: the effects of cortisone and cyclosporin A on normal and nude BALB/c mice. (6602835)
1983
42
Combined neutrophil and T-cell deficiency: initial report of a kindred with features of the hyper-IgE syndrome and chronic granulomatous disease. (6979928)
1982
43
Quantitation of the T cell deficiency in RFM mice with host versus graft disease. (157816)
1979
44
A patient with nucleoside phosphorylase deficiency, selective t-cell deficiency, and autoimmune hemolytic anemia. (102751)
1978
45
Severe molluscum contagiosum infection with T cell deficiency. (301746)
1977
46
Idiopathic late-onset immunoglobulin deficiency with functional T-cell deficiency. (1083220)
1976
47
Report of a patient with T-cell deficiency and normal B-cell function: a new immunodeficiency disease with response to transfer factor. (1081434)
1975
48
T-cell deficiency in patients with squamous cell cancer of the head and neck. (1101724)
1975
49
Chronic mucocutaneous candidiasis: T cell deficiency associated with B cell dysfunction in man. (4549559)
1974
50
T cell deficiency in mouse allogeneic radiation chimeras. (4582262)
1973

Variations for T Cell Deficiency

About this section

Expression for genes affiliated with T Cell Deficiency

About this section

Search GEO for disease gene expression data for T Cell Deficiency.

Pathways for genes affiliated with T Cell Deficiency

About this section

Pathways related to T Cell Deficiency according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5PTPRC, IL2
29.5PTPRC, IL2
3
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.5PTPRC, IL2
4
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.4IL15, IL2
5
Show member pathways
Type III interferon signaling38
9.4IL2, IL15
6
Show member pathways
9.4IL15, IL2
79.4IL15, IL2
89.4IL2, IL15
9
Show member pathways
9.0SMARCAL1, IL15, IL2
10
Show member pathways
9.0PTPRC, IL2, IL15

Compounds for genes affiliated with T Cell Deficiency

About this section

Compounds related to T Cell Deficiency according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1ctla4-ig459.8IL2, IL15
2c-d4t459.8IL2, IL15
3alpha-galactosylceramide459.8IL15, IL2
4daclizumab45 1310.8IL15, IL2
5basiliximab45 1310.8IL15, IL2
6il-12459.8IL2, IL15
7etanercept45 51 1311.8IL15, PTPRC
8okt3459.7IL15, IL2
9gm-csf45 3010.7IL2, IL15
10infliximab45 51 1311.7IL15, PTPRC
11polyinosinic-polycytidylic acid459.7IL2, IL15
12il 10459.7IL15, IL2
13rituximab45 51 1311.6IL15, IL2
14chloroquine45 3 51 30 1313.6IL15, IL2
15herbimycin a45 6110.5PTPRC, IL2
16dmso459.5PTPRC, IL2
17hydrocortisone45 3 61 1312.5IL2, IL15
18cyclophosphamide45 51 1311.3IL15, IL2
19ionomycin459.3IL15, IL2, PTPRC
20histamine45 30 2611.3IL15, IL2, PTPRC
21cyclosporin a45 30 6111.2IL2, PTPRC, IL15
22cycloheximide459.2PTPRC, IL15, IL2
23tacrolimus45 51 1311.1IL15, IL2
24dexamethasone45 51 30 1312.1IL15, IL2, PTPRC

GO Terms for genes affiliated with T Cell Deficiency

About this section

Biological processes related to T Cell Deficiency according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tissue remodelingGO:00341059.6IL2, IL15
2T cell differentiationGO:00302179.5IL2, PTPRC
3positive regulation of interleukin-17 productionGO:00327409.5IL15, IL2
4positive regulation of inflammatory responseGO:00507299.4IL15, IL2
5positive regulation of B cell proliferationGO:00308909.4PTPRC, IL2
6positive regulation of natural killer cell differentiationGO:00328259.2ZBTB1, IL15
7positive regulation of T cell proliferationGO:00421029.2IL15, PTPRC

Molecular functions related to T Cell Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.4IL15, IL2

Products for genes affiliated with T Cell Deficiency

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for T Cell Deficiency

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet