T Cell Deficiency malady

Wikipedia: T cell deficiency is a deficiency of T cells, either caused by lymphocytopenia of T cells or by...⁴⁴ more...

MalaCards: T Cell Deficiency, also known as t-lymphocyte deficiency, is related to immune defect due to absence of thymus and tuberculosis. An important gene associated with T Cell Deficiency is NKCD (Natural killer cell deficiency, familial isolated), and among its related pathways are Primary immunodeficiency and Lymphocyte Signaling. The compounds cyclophosphamide and melphalan have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, smooth muscle and colon, and related mouse phenotypes are respiratory system and craniofacial.

Aliases & Descriptions:

t cell deficiency 6 8 t-lymphocyte deficiency 43

Disease types for t cell deficiency family:

b cell deficiency

Diseases related to t cell deficiency by text searches and GeneDecks gene sharing:

(show top 50)    (show all 688)

id	Related Disease	Score	Top Affiliating Genes
1	immune defect due to absence of thymus	29.2	CD79A, IL1A, IL2, IL4
2	tuberculosis	18.7	VCAM1, RAD51, BCL2, SCP2, MUTYH, BAX
3	b cell deficiency	14.1	BTK, CD79A, IL4, IL5, CCL7, IGLL1
4	intrinsic asthma	14.1	IL4, IL5, CCL7, IGHE
5	egg allergy	14.0	IL4, IL5, IGHE
6	immunodeficiency with hyper igm type 1	14.0	BTK, CD79A, IL4, IGHE, HPRT1
7	food allergy	14.0	SCP2, IL4, IL5, IGHE
8	selective iga deficiency disease	14.0	BTK, CD79A, IL4
9	cough variant asthma	14.0	IL4, IL5, IGHE
10	allergic bronchopulmonary aspergillosis	14.0	IL4, IL5, IGHE
11	allergic conjunctivitis	14.0	IL4, IL5, IGHE
12	allergic rhinitis	13.9	IL4, IL5, IGHE, ICAM1
13	pthirus pubis infestation	13.8	IL5, IGHE, HPRT1, NGF
14	interleukin receptor	13.8	IL2RG, IL4, IL5, NGF
15	immunodeficiency, centromere instability and facial anomalies syndrome	13.8	CD79A, DNMT3B, DNMT1
16	corneal disease	13.8	IL1A, NGF, KRT12, KRT3
17	contact dermatitis	13.7	IL1A, IL5, IGHE
18	breast cancer	13.7	RAD51, XRCC3, ATM
19	vulvovaginitis	13.7	CD79A, IL4, IL5, IGHE, ESR1
20	cerebral palsy	13.7	CD79A, IL15, IL4, ANXA5, CCL7, HPRT1
21	lynch syndrome	13.6	BRCA2, MSH2, MLH1, HPRT1
22	bladder cancer susceptibility	13.6	PARP1, MUTYH, ERCC2, OGG1
23	vernal keratoconjunctivitis	13.6	VCAM1, IL4, IL5, CCL7, IGHE, ICAM1
24	attenuated familial adenomatous polyposis	13.6	MUTYH, MSH2, OGG1
25	kimura disease	13.6	IL4, IL5, IGHE, IFNA1
26	henoch-schoenlein purpura	13.6	VCAM1, CD79A, ICAM1
27	echinococcosis	13.5	LAT, CD79A, IL4, IL5, IGHE, IFNG
28	urinary schistosomiasis	13.5	IL4, IL5, IGHE, IFNG
29	omenn syndrome	13.5	IL2RG, IL4, IL5, IGHE, IFNG
30	pulmonary eosinophilia	13.5	IL4, IL5, CCL7, CCL3, IGHE, IFNG
31	paroxysmal nocturnal hemoglobinuria	13.5	PIGA, ANXA5, HPRT1, PLCG1, PLAUR
32	cicatricial pemphigoid	13.5	CD79A, IL1A, IL4, IL5, IGHE, IFNG
33	skin benign neoplasm	13.5	MSH2, MLH1, HPRT1, ERCC2, TP63, KRT13
34	middle ear cholesteatoma	13.4	IL1A, ICAM1, KRT13, EGF
35	bronchiolo-alveolar adenocarcinoma	13.4	MUC4, JUP, CDH1, DNMT1
36	hemoglobinuria	13.4	PIGA, ANXA5, HPRT1, PLCG1, PLAUR
37	acoustic neuroma	13.4	RAD51, PARP1, MUTYH, XRCC2, XRCC3, MSH2
38	fabry disease	13.4	BTK, VCAM1, UGCG, IL1A, ICAM1, NPPB
39	gamma heavy chain disease	13.4	BTK, IL15, IL2, IL2RG, IL4
40	stachybotrys chartarum	13.4	IL1A, CCL7, CCL3
41	agammaglobulinemia	13.4	BTK, CD79A, IL2, IL4, CXCL12
42	syphilis	13.4	CD79A, CD4, ANXA5, IGHE
43	uterine adnexa cancer	13.4	MSH2, MLH1, ESR1
44	crescentic glomerulonephritis	13.4	VCAM1, CD79A, CCL3, ICAM1, SPP1
45	poliomyelitis	13.4	BTK, FCGR2A, IL4, IFNG, ICAM1
46	eosinophilic meningitis	13.3	IL2, IL4, IL5
47	thrombocytosis	13.3	CD79A, IL1A, IL4, IFNA1, TBXA2R, CXCL12
48	paranasal sinus disease	13.3	IL5, IFNG, PLAUR
49	mantle cell lymphoma	13.3	BCL2, ATM, MDM2, CCND1
50	pancreatic cancer	13.3	BRCA2, MUC4, BAK1, CDKN1A, CCND1, KRT19

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to t cell deficiency:

²²

MGI Mouse Phenotypes related to t cell deficiency:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.1	POLB, ELN, SNAP25, TBXA2R, PTPRC, TP63
2	craniofacial phenotype	MP:0005382	9.7	DNMT3B, HPRT1, ALPL, MAPK8, IL2RG, XRCC2
3	endocrine/exocrine gland phenotype	MP:0005379	9.2	H2AFX, SNAP25, NR5A1, TMPO, TP63, HPRT1
4	embryogenesis phenotype	MP:0005380	8.8	PIGA, NCOR1, SFN, BRCA2, RAD51, RAD51C
5	pigmentation phenotype	MP:0001186	8.7	PRKDC, DNMT1, TP53, ERCC2, HPRT1, FAS
6	renal/urinary system phenotype	MP:0005367	8.7	PTPRC, SMARCAL1, TAGLN, PRKDC, POLB, TP63
7	normal phenotype	MP:0002873	8.6	PTPRC, NR1H2, NR5A1, CRABP1, KRT12, DNMT1
8	liver/biliary system phenotype	MP:0005370	8.5	NCOR1, NCOR2, SFN, SCP2, LAT, JUND
9	hearing/vestibular/ear phenotype	MP:0005377	8.3	HPRT1, SNAP25, CRABP1, PLCG1, ABCB1, PRKDC
10	hematopoietic system phenotype	MP:0005397	8.2	DNMT1, STAT2, PRKDC, POLB, SLC31A1, HDC
11	no phenotypic analysis	MP:0003012	8.1	ESR1, TP53, SMARCAL1, KRT12, KRT19, DNMT1
12	limbs/digits/tail phenotype	MP:0005371	7.9	ALPL, ESR1, TP63, TMPO, CRABP1, STAT1
13	reproductive system phenotype	MP:0005389	7.9	PIGA, SFN, BRCA2, RAD51C, CDH1, MLH1
14	adipose tissue phenotype	MP:0005375	7.7	HDC, PRKDC, TP53, ERCC2, ESR1, ALPL
15	skeleton phenotype	MP:0005390	6.8	TP53, TP63, PTPRC, SPP1, NR1H2, SNAP25
16	immune system phenotype	MP:0005387	6.7	NCOR1, CCL3, IGLL1, IFNG, ALPL, HPRT1
17	nervous system phenotype	MP:0003631	6.7	CD4, DNMT1, TAGLN, STAT1, PRKDC, CXCL12
18	vision/eye phenotype	MP:0005391	6.4	NGF, SNAP25, TP63, TP53, KRT12, EGF
19	behavior/neurological phenotype	MP:0005386	6.4	PLAUR, SNAP25, NR5A1, SPP1, ERCC2, HPRT1
20	muscle phenotype	MP:0005369	6.3	TP53, TP63, SPP1, NR1H2, SNAP25, PLAUR
21	integument phenotype	MP:0010771	5.6	PIGA, NCOR1, SFN, BTK, BRCA2, PARP1
22	mortality/aging	MP:0010768	5.6	FANCL, H2AFX, DNMT3B, DNMT1, TAGLN, STAT2
23	digestive/alimentary phenotype	MP:0005381	5.5	PIGA, NCOR2, SFN, BTK, BRCA2, MYO1A
24	tumorigenesis	MP:0002006	4.3	IL5, DNMT1, TAGLN, STAT1, PRKDC, OGG1
25	growth/size phenotype	MP:0005378	4.2	LAMTOR2, XRCC2, ATM, JUND, JUP, CDKN1A
26	cardiovascular system phenotype	MP:0005385	3.8	PLAUR, PLCG1, SNAP25, NR5A1, NR1H2, SPP1
27	homeostasis/metabolism phenotype	MP:0005376	2.4	SLC31A1, HDC, GDI1, LAMTOR2, LAT, LAT2
28	cellular phenotype	MP:0005384	1.4	PIGA, NCOR1, NCOR2, SFN, BTK, BRCA2

Articles related to t cell deficiency:

(show top 50)    (show all 71)

id	Title	Authors	Year	Affiliating Genes
1	Predominant Sertoli cell deficiency in a 46,XY disord ers of sex development patient with a new NR5A1/SF-1 mutation transmitted by hi s unaffected father. (21163476)	Philibert P.... Sultan C.	2011	NR5A1
2	Conditional deletion of TGF-I^R1 using Langerin-Cre mi ce results in Langerhans cell deficiency and reduced contact hypersensitivity. (21998450)	Zahner S.P.... Clausen B.E.	2011	CD207, TGFBRAP1
3	Aurora-A expressing tumour cells are deficient for ho mology-directed DNA double strand-break repair and sensitive to PARP inhibition . (20373286)	Sourisseau T.... Linardopoulos S.	2010	RAD51, PARP1, AURKA
4	Coincidence of moderately elevated N-terminal pro-B-t ype natriuretic peptide, endothelial progenitor cells deficiency and propensity to exercise-induced myocardial ischemia in stable angina. (20364046)	Surdacki A.... Dubiel J.S.	2010	NPPB
5	Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuc lear ribonucleoprotein L-like mutation. (20505149)	Wu Z.... Goodnow C.C.	2010	PTPRC, HNRPLL
6	Limbal stem cell deficiency after chemical burns : i nvestigations on the epithelial phenotype and inflammation status (19165487)	Pauklin M.... Meller D.	2009	ICAM1, KRT19, KRT3
7	Origin and fate of blood cells deficient in glycosylp hosphatidylinositol-anchored protein among patients with bone marrow failure. (19656154)	Sugimori C.... Nakao S.	2009	PIGA
8	Cells deficient in oxidative DNA damage repair genes Myh and Ogg1 are sensitive to oxidants with increased G2/M arrest and multinucleation. (18258604)	Xie Y.... Shiu R.P.	2008	OGG1, MUTYH
9	Systemic lupus erythematosus patients have increased number of circulating plasmacytoid dendritic cells, but decreased myeloid dendritic cells with deficient CD83 expression. (18625638)	Jin O.... Lau C.S.	2008	CD83
10	Comparative toxicity of arsenite metabolites in wild type CHO cells and in cells deficient in excision repair cross-complementing 1 and 2. (18602460)	Vahidnia A.... de Wolff F.A.	2008	ERCC2
11	Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: roles of IL-2 versus IL-15. (18465774)	Yang C.H.... Huang F.P.	2008	IL2, IL15
12	Phenotypic study after cultivated limbal epithelial transplantation for limbal stem cell deficiency. (17923540)	Kawashima M.... Shimazaki J.	2007	KRT13, KRT3
13	Reduced Mcm2 expression results in severe stem/progenitor cell deficiency and cancer. (17717065)	Pruitt S.C.... Freeland A.	2007	MDM2
14	Regulation of corneal angiogenesis in limbal stem cell deficiency. (17079182)	Ma D.H.... Yu J.S.	2006	SFN
15	Familial NK cell deficiency associated with impaired IL-2- and IL-15-dependent survival of lymphocytes. (17142786)	Eidenschenk C.... Casanova J.L.	2006	IL2, IL15
16	Clinical and cytological findings in limbal stem cell deficiency. (15778841)	Sacchetti M.... Bonini S.	2005	KRT3
17	Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity. (16356859)	Kaplan D.H.... Shlomchik M.J.	2005	CD207
18	Human cells deficient in transcription-coupled repair show prolonged activation of the Jun N-terminal kinase and increased sensitivi ty following cisplatin treatment. (15841377)	Bulmer J.T.... Rainbow A.J.	2005	MAPK8
19	Cell cycle progression stimulated by tamoxifen-bound estrogen receptor-alpha and promoter-specific effects in breast cancer cells deficient in N-CoR and SMRT. (15802375)	Keeton E.K.... Brown M.	2005	EGF, CCND1, ESR1
20	Smooth muscle cells deficient in osteopontin have enhanced susceptibility to calcification in vitro. (15820201)	Speer M.Y.... Giachelli C.M.	2005	SPP1, TAGLN
21	Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2. (15375219)	Daniels M.J.... Venkitaraman A.R.	2004	BRCA2
22	Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding. (15153499)	Janssen E.... Zhang W.	2004	PLCG1, LAT, LAT2
23	Analysis of p63 and cytokeratin expression in a cultivated limbal autograft used in the treatment of limbal stem cell deficiency. (15317707)	Harkin D.G.... Apel A.J.	2004	KRT3
24	Reduced apoptotic response to camptothecin in CHO cells deficient in XRCC3. (12584174)	Hinz J.M.... Meuth M.	2003	RAD51C, XRCC2, XRCC3
25	Analysis of limbal stem cell deficiency by corneal impression cytology. (12883346)	Donisi P.M.... Ponzin D.	2003	KRT3
26	8-hydroxydeoxyguanosine causes death of human leukemia cells deficient in 8-oxoguanine glycosylase 1 activity by inducing apoptosis. (12612057)	Hyun J.W.... Chung M.H.	2003	OGG1
27	Characterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport system. (12177073)	Lee J.... Thiele D.J.	2002	SLC31A1
28	Reduced expression of Bcl-2 in CD8+ T cells deficient in the IL-15 receptor alpha-chain. (11777964)	Wu T.S.... Liao N.S.	2002	IL15RA
29	Defects in cytokinesis, actin reorganization and the contractile vacuole in cells deficient in RhoGDI. (12198156)	Rivero F.... Meyer A.K.	2002	GDI1
30	A novel gene, Pog, is necessary for primordial germ cell proliferation in the mouse and underlies the germ cell deficient mutation, gcd. (12417526)	Agoulnik A.I.... Bishop C.E.	2002	FANCL
31	Novel Igalpha (CD79a) gene mutation in a Turkish patient with B cell- deficient agammaglobulinemia. (11920841)	Wang Y.... Miyawaki T.	2002	CD79A
32	Genesis of progressive T-cell deficiency owing to a single missense mutation in the common gamma chain gene. (11902333)	Goldman A.S.... Schmalstieg F.C.	2001	ANXA5
33	Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. (11591325)	Yan M.... Dixit V.M.	2001	TNFRSF13C
34	Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2. (11196174)	Wang H.... Iliakis G.	2001	BRCA2
35	Glioma cells deficient in urokinase plaminogen activator receptor expression are susceptible to tumor necrosis factor-alpha-related apoptosis-inducing ligand-induced apoptosis. (11751520)	Krishnamoorthy B.... Rao J.S.	2001	PLAUR
36	High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6. (11717437)	Chen S.... Modrich P.	2001	CAD
37	Common cytokine receptor gamma chain (gammac)-deficient B cells persist in T cell-deficient gammac-mice and respond to a T-independent antigen. (10898497)	Vosshenrich C.A.... Di Santo J.P.	2000	IL2RG
38	Chronic photodamage in skin of mast cell-deficient mice. (10461464)	Gonzalez S.... Kochevar I.E.	1999	ELN
39	Antigen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine expression in B cell-deficient mice. (10030835)	MacLean J.A.... De Sanctis G.T.	1999	IL4, CCL7, IL5
40	Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice. (9642684)	Corry D.B.... Locksley R.M.	1998	IGHE
41	Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia. (9419212)	Minegishi Y.... Conley M.E.	1998	IGLL1
42	Intramuscular injection of hrRANTES causes mast cell recruitment and increased transcription of histidine decarboxylase in mice: lack of effects in genetically mast cell-deficient W/WV mice. (9837859)	Conti P.... Theoharides T.C.	1998	HDC
43	Plakoglobin induces desmosome formation and epidermoid phenotype in N-cadherin-expressing squamous carcinoma cells deficient in plakoglobin and E-cadherin. (9605974)	Parker H.R.... Pasdar M.	1998	CDH1, JUP
44	Acetylcholine exocytosis in PC12 cells deficient in S NAP-25. (9243624)	Ray P.... Ray R.	1997	SNAP25
45	P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake. (8577747)	De Graaf D.... Roninson I.B.	1996	ABCB1
46	Selection against blood cells deficient in hypoxanthine phosphoribosyltransferase (HPRT) in Lesch-Nyhan heterozygotes occurs at the level of multipotent stem cells. (8522326)	Hakoda M.... Kashiwazaki S.	1995	HPRT1
47	Interferon-resistant Daudi cells are deficient in interferon-alpha-induced ISGF3 alpha activation, but remain sensitive to the interferon-alpha-induced increase in ISGF3 gamma content. (8301159)	Dron M.... Tovey M.G.	1993	IRF9
48	Fc gamma RIIA-mediated phagocytosis and receptor phosphorylation in cells deficient in the protein tyrosine kinase Src. (8405229)	Hunter S.... Schreiber A.D.	1993	FCGR2A
49	Preferential translation of heat shock mRNAs in HeLa cells deficient in protein synthesis initiation factors eIF-4E and eIF-4 gamma. (1400417)	Joshi-Barve S.... Rhoads R.E.	1992	EIF4G1
50	Retinoic acid stimulates the differentiation of PC12 cells that are deficient in cAMP-dependent protein kinase. (1645738)	Scheibe R.J.... Wagner J.A.	1991	NGF, CRABP1

Genes related to t cell deficiency according to GeneCards:

(show top 50)    (show all 107)

id	Symbol	Description	Score	GeneCards Section Context
1	NKCD	Natural killer cell deficiency, familial isolated	11.0	Aliases & Descriptions
2	IGLL1	immunoglobulin lambda-like polypeptide 1	11.0	Publications, Summaries
3	SCP2	sterol carrier protein 2	11.0	Summaries, Publications
4	TNFRSF13C	tumor necrosis factor receptor superfamily, member 13C	10.9	Publications
5	CCL7	chemokine (C-C motif) ligand 7	10.9	Publications
6	BTK	Bruton agammaglobulinemia tyrosine kinase	10.9	Publications
7	TEC	tec protein tyrosine kinase	10.9	Publications
8	CD79A	CD79a molecule, immunoglobulin-associated alpha	10.9	Publications
9	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	10.9	Publications
10	IL4	interleukin 4	10.9	Publications
11	IGHE	immunoglobulin heavy constant epsilon	10.9	Publications
12	LAMTOR2	late endosomal/lysosomal adaptor, MAPK and MTOR activator 2	10.9
13	KRT3	keratin 3	10.9	Publications
14	KRT12	keratin 12	10.9	Publications
15	SLC35B4	solute carrier family 35, member B4	10.9	Orthologs
16	CD207	CD207 molecule, langerin	10.9	Publications
17	LAT2	linker for activation of T cells family, member 2	10.9	Publications
18	GDI1	GDP dissociation inhibitor 1	10.9	Publications
19	TAGLN	transgelin	10.9	Publications
20	HNRPLL	heterogeneous nuclear ribonucleoprotein L-like	10.9	Publications
21	SLC31A1	solute carrier family 31 (copper transporters), member 1	10.9	Publications
22	CRABP1	cellular retinoic acid binding protein 1	10.9	Publications
23	MYO1A	myosin IA	10.9	Publications
24	LAT	linker for activation of T cells	10.9	Publications
25	KRT13	keratin 13	10.9	Publications
26	IRF9	interferon regulatory factor 9	10.9	Publications
27	RAD51C	RAD51 homolog C (S. cerevisiae)	10.9	Publications
28	IL2RG	interleukin 2 receptor, gamma	10.9	Publications
29	PIGA	phosphatidylinositol glycan anchor biosynthesis, class A	10.9	Publications
30	HDC	histidine decarboxylase	10.9	Publications
31	IL15RA	interleukin 15 receptor, alpha	10.9	Publications
32	JUND	jun D proto-oncogene	10.9	Publications
33	ZBTB1	zinc finger and BTB domain containing 1	10.9
34	SFN	stratifin	10.9	Publications
35	STAT2	signal transducer and activator of transcription 2, 113kDa	10.9	Publications
36	CAD	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	10.9	Publications
37	XRCC2	X-ray repair complementing defective repair in Chinese hamster cells 2	10.9	Publications
38	TGFBRAP1	transforming growth factor, beta receptor associated protein 1	10.9	Publications
39	CD83	CD83 molecule	10.9	Publications
40	XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	10.9	Publications
41	MUTYH	mutY homolog (E. coli)	10.9	Publications
42	EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	10.9	Publications
43	UGCG	UDP-glucose ceramide glucosyltransferase	10.9	Orthologs
44	NR5A1	nuclear receptor subfamily 5, group A, member 1	10.9	Publications
45	ALPL	alkaline phosphatase, liver/bone/kidney	10.9	Publications
46	POLB	polymerase (DNA directed), beta	10.9	Publications
47	BAK1	BCL2-antagonist/killer 1	10.9	Publications
48	TBXA2R	thromboxane A2 receptor	10.9	Publications
49	FANCL	Fanconi anemia, complementation group L	10.9	Publications
50	H2AFX	H2A histone family, member X	10.9	Publications

Pathways related to t cell deficiency according to GeneDecks:

(show top 50)    (show all 124)

id	Pathway	Score	Top Affiliating Genes
1	Primary immunodeficiency20	10.5	BTK, CD4, IL2RG, IGLL1
2	Lymphocyte Signaling3	10.4	CD4, BTK, LAT, TEC, LAT2
3	IL-6 Pathway36	10.3	BTK, BAX, CCL7, IL4, CCL3, IL5
4	Intestinal immune network for IgA production20	10.1	CXCL12, IL15, IL15RA, IL2, IL4, IL5
5	RAR-Gamma-RXR-Alpha Degradation36	10.0	BTK, IL2, CCL7, CCL3, IL15, CXCL12
6	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.0	IL2, IL15, CCL3, IL2RG, BCL2, IL15RA
7	Endothelin-1 Signaling Pathway36	9.9	CXCL12, IL2, CCL7, IL4, IL5, IL1A
8	OX40 Pathway36	9.9	IL5, MAPK8, IL4, BCL2
9	DNA damage_Role of Brca1 and Brca2 in DNA repair41	9.7	H2AFX, ATM, POLB, BRCA2, RAD51, MSH2
10	DNA damage Role of Brca1 and Brca2 in DNA repair10	9.7	POLB, H2AFX, TP53, FANCL, MSH2, ATM
11	Immune System38	9.6	IRF9, VCAM1, TEC, ICAM1, IFNG, IL5
12	Osteoclast differentiation20	9.6	BTK, JUND, IRF9, FCGR2A, MAPK8, IFNG
13	ATM Pathway36	9.5	RAD51, H2AFX, ATM, CDKN1A, MAPK8, TP53
14	DNA Damage3	9.4	TP63, MDM2, MSH2, MUTYH, BRCA2, TP53
15	MIF Mediated Glucocorticoid Regulation36	9.4	BAX, BCL2, BTK, IL1A, IL15, IL5
16	all-trans-Retinoic Acid Signaling in Brain36	9.4	CCL3, CCL7, CXCL12, IL5, IL4, IL2
17	PEDF Induced Signaling36	9.4	BAX, BTK, CXCL12, BCL2, CCL3, IL15
18	T cell receptor signaling pathway20	9.3	LAT, TEC, CD4, CD247, IL2, IL4
19	Akt Signaling36	9.3	IL2RG, MDM2, CCL7, CCND1, CCL3, CXCL12
20	PGC1Alpha Pathway36	9.3	IL1A, IL2RG, IL2, IL4, IL5, CCL7
21	Cytokine Network36	9.2	IFNA1, IL1A, IL2, IFNG, IL15, IL4
22	p53 Signaling36	9.2	SFN, BCL2, BAX, ATM, CDKN1A, MDM2
23	ICos-ICosL Pathway in T-Helper Cell36	9.1	PTPRC, PLCG1, TEC, HLA-DPA1, IL2, CD4
24	NFAT Signaling and Lymphocyte Interactions36	9.1	BTK, BAX, BCL2, CD4, IL15, IL1A
25	DNA Repair Mechanisms36	9.1	MSH2, RAD51, BRCA2, OGG1, POLB, ATM
26	MIF Regulation of Innate Immune Cells36	9.1	IL15, IL1A, BAX, IL4, BCL2, MAPK8
27	Transcription_P53 signaling pathway41	9.0	BCL2, ERCC2, ATM, CDKN1A, TP53, MAPK8
28	Apoptotic Pathways Triggered By HIV136	8.9	PTPRC, CD4, BCL2, MAPK8, BAK1, BAX
29	Jak-STAT signaling pathway20	8.9	CCND1, STAT1, STAT2, IFNG, IL5, IFNA1
30	Measles20	8.9	IL4, IFNG, IRF9, IL1A, IL2, CCND1
31	PAK Pathway36	8.8	CCL7, MAPK8, IL5, IL4, CCL3, IL2
32	Cell Cycle / Checkpoint Control3	8.8	MLH1, CDKN1A, MDM2, TP53, TP63, TMPO
33	p53 signaling pathway20	8.8	ATM, TP53, CCND1, FAS, MDM2, CDKN1A
34	SOCS Pathway36	8.7	BTK, BCL2, BAX, CD4, IL15, IL1A
35	STAT3 Pathway36	8.6	IL15RA, IL1A, IL2, IL2RG, IL4, IL15
36	Regulation of eIF4 and p70S6K36	8.6	EIF4G1, CD4, IL4, EGF, CCL3, CCL7
37	Glucocorticoid Receptor Signaling36	8.4	CD4, BCL2, BTK, IL2, NCOR2, NCOR1
38	ERK Signaling36	8.3	IL5, IL4, IL2, IL1A, LAT, BTK
39	MAPK Family Pathway36	8.1	IL4, IL5, IL2RG, IL1A, BTK, BCL2
40	Antioxidant Action of Vitamin-C36	8.1	IL2, BCL2, BAX, CD4, IL15, IL15RA
41	p38 Signaling36	8.1	JUND, BAX, BCL2, IL1A, BTK, CXCL12
42	Tec Kinases Signaling36	8.0	IL1A, CCL3, TNFRSF13C, CXCL12, STAT1, STAT2
43	TGF-Beta Pathway36	7.9	BTK, CXCL12, TNFRSF13C, IL4, IL1A, IL2
44	Colorectal Cancer Metastasis36	7.8	EGF, TP53, IFNG, CCND1, MLH1, CDH1
45	Rho Family GTPases36	7.8	MAPK8, CCL3, IL2, IL1A, SPP1, EGF
46	Cytokine-cytokine receptor interaction20	7.8	CCL7, IL2, CXCL12, EGF, TNFRSF13C, IFNG
47	JNK Pathway36	7.6	BCL2, BAX, CD4, CXCL12, EGF, TP53
48	JAK-STAT Pathway36	7.5	STAT1, STAT2, IL2RG, IL4, IL5, CCL7
49	Pathways in cancer20	7.2	FAS, BAX, MSH2, RAD51, JUP, EGF
50	Molecular Mechanisms of Cancer36	6.9	BAX, IL2RG, IL2, IL15RA, IL15, CDH1

Compounds related to t cell deficiency according to GeneDecks:

(show top 50)    (show all 336)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.7	PIGA, NPPB
2	melphalan32 9 9	11.3	RAD51, XRCC3, CD79A, IL4, IFNA1, IFNG
3	h2o232	9.2	BRCA2, RAD51, MUTYH, JUND, CD79A, FCGR2A
4	ly29400232	9.0	CDH1, FCGR2A, IL4, ANXA5, MAPK8, CCND1
5	n acetylcysteine32	8.8	VCAM1, XRCC3, ATM, CD79A, CDKN1A, CDH1
6	arginine32	8.7	BTK, RAD51, CD79A, CD247, MLH1, FCGR2A
7	histamine32 18	9.6	BTK, VCAM1, JUP, CD79A, CDH1, FCGR2A
8	mitomycin c32	8.5	BRCA2, VCAM1, RAD51, XRCC2, XRCC3, ATM
9	pdtc32	8.4	VCAM1, PARP1, BCL2, CDKN1A, IL1A, IL4
10	pge232	8.1	VCAM1, CD4, CD83, CDH1, IL1A, IL5
11	imatinib32 34 9 9	10.9	RAD51, PARP1, BCL2, CDKN1A, IL4, IL5
12	cysteine32	7.9	BTK, PARP1, BAK1, CD79A, CD4, CDH1
13	adpribose32	7.7	BRCA2, PARP1, BCL2, BAK1, BAX, CDKN1A
14	2-chlorodeoxyadenosine32	7.7	PARP1, BCL2, BAX, IL2, IL5, MDM2
15	sb 20358032 42	8.6	BTK, VCAM1, PARP1, BCL2, JUND, CDKN1A
16	depsipeptide32	7.6	BCL2, BAX, CDKN1A, CDH1, FAS, ANXA5
17	camptothecin32 42 9 9	10.6	BRCA2, RAD51, RAD51C, PARP1, BCL2, BAK1
18	oxygen32 18	8.5	MYO1A, PARP1, BCL2, MUTYH, BAK1, BAX
19	fludarabine32 9 9	9.4	PARP1, BCL2, BAK1, BAX, IL2, MDM2
20	progesterone32 42 9 18 9	11.4	NCOR1, NCOR2, BRCA2, BCL2, MUC4, CDKN1A
21	estrogen32	7.3	NCOR1, NCOR2, BRCA2, RAD51, MUC4, AURKA
22	irinotecan32 34 9 9	10.3	PARP1, BAK1, BAX, CDKN1A, CDH1, MLH1
23	curcumin32	7.2	VCAM1, PARP1, BCL2, BAK1, BAX, JUND
24	etoposide32 42 9 9	10.0	PARP1, BCL2, BAK1, BAX, ATM, CDKN1A
25	vitamin d32	6.9	NCOR1, NCOR2, CD79A, CDKN1A, CDH1, IL1A
26	arsenite32 18	7.7	PARP1, BCL2, BAX, CDKN1A, MDM2, FAS
27	butyrate32	6.7	BCL2, BAK1, BAX, CDKN1A, CDH1, IL5
28	wortmannin32 42	7.5	BTK, VCAM1, RAD51, BCL2, BAX, ATM
29	herbimycin a32 42	7.5	VCAM1, CD4, CDH1, IL1A, IL2, IL4
30	pd 98,05932	6.4	VCAM1, PARP1, BCL2, BAX, JUND, CDKN1A
31	adriamycin32	6.3	BRCA2, BCL2, UGCG, BAX, CDKN1A, CDH1
32	vegf32	6.2	VCAM1, RAD51, PARP1, BCL2, JUP, CDKN1A
33	phosphatidylinositol32	6.1	PIGA, NCOR2, BTK, BRCA2, VCAM1, BCL2
34	paraffin32	6.0	BRCA2, VCAM1, BCL2, BAK1, BAX, MSH2
35	5-aza-2deoxycytidine32	6.0	JUP, CDKN1A, CDH1, MLH1, MDM2, FAS
36	mg 13232 42	7.0	NCOR2, PARP1, BAX, CDKN1A, CDH1, IL1A
37	doxorubicin32 34 9 9	8.9	PARP1, UGCG, BAK1, MSH2, ATM, CDH1
38	retinoid32	5.7	NCOR1, NCOR2, BCL2, BAK1, BAX, CDKN1A
39	testosterone32 9 18 9	8.6	NCOR1, NCOR2, BRCA2, VCAM1, SCP2, CD79A
40	thymidine32 18	6.2	BRCA2, RAD51, JUND, CDKN1A, MLH1, IL15
41	paclitaxel32 34 9 9	8.1	BRCA2, RAD51, PARP1, BCL2, UGCG, BAK1
42	tamoxifen32 34 9 9	7.8	NCOR1, NCOR2, BRCA2, VCAM1, BCL2, UGCG
43	5fluorouracil32	4.3	BCL2, BAK1, BAX, MSH2, CDKN1A, CDH1
44	dexamethasone32 42 34 9 9	8.1	VCAM1, PARP1, BCL2, MUC4, BAK1, JUND
45	tyrosine32	4.0	NCOR2, BTK, VCAM1, RAD51, MUC4, BAK1
46	cisplatin32 34 9 9	7.0	BRCA2, RAD51, PARP1, BCL2, UGCG, BAK1
47	retinoic acid32 42 18	5.8	NCOR1, NCOR2, BRCA2, VCAM1, PARP1, UGCG
48	actinomycin d32	3.8	PARP1, BCL2, BAK1, BAX, CDKN1A, FCGR2A
49	serine32	3.5	BTK, VCAM1, MYO1A, BCL2, UGCG, AURKA
50	cycloheximide32	3.1	BRCA2, RAD51, PARP1, BCL2, BAK1, BAX

Cellular components related to t cell deficiency according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	pore complex	GO:046930	9.9	BCL2, BAK1, BAX
2	membrane raft	GO:045121	9.3	SNAP25, PTPRC, FAS, CD4, CD79A, LAT2
3	external side of plasma membrane	GO:009897	8.5	IFNG, ICAM1, TNFRSF13C, PTPRC, CXCL12, ANXA5
4	extracellular space	GO:005615	7.8	IFNG, ICAM1, ALPL, SPP1, NGF, EGF
5	nucleoplasm	GO:005654	6.8	POLB, ESR1, ERCC2, TP53, TP63, NR1H2
6	cytoplasm	GO:005737	6.2	CRABP1, SNAP25, NR1H2, TEC, TP63, TP53
7	nucleus	GO:005634	4.5	TP63, TP53, ERCC2, ESR1, HNRPLL, CAD

Biological processes related to t cell deficiency according to GeneDecks:

(show all 48)

id	Name	GO ID	Score	Top Affiliating Genes
1	B cell receptor signaling pathway	GO:050853	10.5	PTPRC, TEC, CD79A, LAT2, BCL2, BTK
2	B cell differentiation	GO:030183	10.4	PTPRC, IL4, CD79A, MSH2, VCAM1
3	double-strand break repair via homologous recombination	GO:000724	10.3	H2AFX, ATM, XRCC2, RAD51, BRCA2
4	response to ionizing radiation	GO:010212	10.3	DNMT3B, H2AFX, ICAM1, ATM, VCAM1
5	base-excision repair	GO:006284	10.3	POLB, OGG1, TP53, MUTYH, PARP1
6	B cell homeostasis	GO:001782	10.3	TNFRSF13C, BAX, BAK1, BCL2
7	regulation of protein heterodimerization activity	GO:043497	10.2	BAX, BAK1, BCL2
8	response to radiation	GO:009314	10.2	CXCL12, OGG1, KRT13, NGF, BCL2
9	response to X-ray	GO:010165	10.2	BRCA2, XRCC2, MSH2, CCND1
10	regulation of protein homodimerization activity	GO:043496	10.2	BAX, BAK1, BCL2
11	positive regulation of T cell proliferation	GO:042102	10.1	PTPRC, TNFRSF13C, IFNG, IL4, IL15, VCAM1
12	B cell proliferation	GO:042100	10.1	BCL2, CD79A, PTPRC
13	B cell lineage commitment	GO:002326	10.1	PRKDC, TP53, BCL2
14	T cell receptor signaling pathway	GO:050852	10.1	PLCG1, PTPRC, HLA-DPA1, CD247, CD4, LAT
15	double-strand break repair	GO:006302	10.1	PRKDC, H2AFX, TP53, ATM, RAD51, BRCA2
16	response to ethanol	GO:045471	10.1	BCL2, BAK1, IL4, CCND1, ICAM1, POLB
17	positive regulation of B cell proliferation	GO:030890	10.0	PTPRC, TNFRSF13C, IL5, IL4, IL2, CDKN1A
18	release of cytochrome c from mitochondria	GO:001836	10.0	TP53, BAX, BAK1, BCL2, SFN
19	interferon-gamma-mediated signaling pathway	GO:060333	10.0	STAT1, HLA-DPA1, ICAM1, IFNG, IRF9, VCAM1
20	cell aging	GO:007569	9.9	TP63, TP53, ICAM1, BCL2, BRCA2
21	positive regulation of isotype switching to IgG isotypes	GO:048304	9.9	PTPRC, IFNG, IL4, IL2
22	cellular response to amino acid stimulus	GO:071230	9.9	LAMTOR2, CDH1, DNMT3B, DNMT1
23	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO:070059	9.8	BAX, BAK1, BCL2
24	inflammatory response	GO:006954	9.8	NPPB, NGF, SPP1, TBXA2R, CCL3, CCL7
25	response to organic cyclic compound	GO:014070	9.8	NPPB, ICAM1, CCND1, IL4, IL1A, CD83
26	DNA repair	GO:006281	9.7	FANCL, ERCC2, H2AFX, PRKDC, OGG1, POLB
27	cytokine-mediated signaling pathway	GO:019221	9.7	STAT1, STAT2, EIF4G1, PLCG1, HLA-DPA1, ICAM1
28	immune response	GO:006955	9.7	CCL7, IGLL1, IGHE, HLA-DPA1, CXCL12, IL5
29	response to organic nitrogen	GO:010243	9.6	CDKN1A, IL1A, CCND1, PLCG1
30	positive regulation of gene expression	GO:010628	9.6	DNMT1, DNMT3B, NGF, PLAUR, CCL3, MAPK8
31	response to gamma radiation	GO:010332	9.6	BRCA2, PRKDC, PTPRC, TP53, IL1A, XRCC2
32	induction of apoptosis by intracellular signals	GO:008629	9.5	TP53, MAPK8, CDKN1A, BAX, BAK1, BCL2
33	virus-host interaction	GO:019048	9.5	PLCG1, KRT19, EIF4G1, STAT2, STAT1, TP53
34	response to DNA damage stimulus	GO:006974	9.4	POLB, H2AFX, TP53, CCND1, FANCL, CDKN1A
35	response to peptide hormone stimulus	GO:043434	9.4	FAS, NGF, STAT1, CXCL12, NPPB
36	negative regulation of gene expression	GO:010629	9.4	PLAUR, ESR1, CCL3, CDKN1A, BAK1
37	activation of pro-apoptotic gene products	GO:008633	9.3	MAPK8, FAS, BAX, BAK1, BCL2
38	neuron apoptotic process	GO:051402	9.2	BAX, ATM, FAS, TP53, TP63, BCL2
39	negative regulation of apoptotic process	GO:043066	9.2	CXCL12, PLAUR, TP53, ERCC2, MAPK8, MDM2
40	response to hypoxia	GO:001666	9.2	NPPB, CXCL12, ERCC2, FAS, IL1A, ATM
41	response to toxin	GO:009636	9.1	CCL3, FAS, CDH1, CDKN1A, BAX, BCL2
42	positive regulation of apoptotic process	GO:043065	9.1	PRKDC, PTPRC, TP53, ANXA5, FAS, ATM
43	induction of apoptosis by extracellular signals	GO:008624	9.0	NGF, BTK, BAK1, BAX, FAS, MAPK8
44	response to estrogen stimulus	GO:043627	8.6	KRT19, ESR1, CCND1, FAS, BCL2
45	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.9	PRKDC, STAT1, NR5A1, NR1H2, TP63, TP53
46	signal transduction	GO:007165	7.7	ESR1, CRABP1, PLCG1, PLAUR, EGF, TGFBRAP1
47	response to drug	GO:042493	7.6	ICAM1, TBXA2R, NGF, ABCB1, DNMT3B, NPPB
48	apoptotic process	GO:006915	7.4	MAPK8, IFNG, ERCC2, TP53, TP63, NGF

Molecular functions related to t cell deficiency according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	DNA-dependent ATPase activity	GO:008094	10.1	SMARCAL1, ERCC2, XRCC3, XRCC2, RAD51C
2	protein N-terminus binding	GO:047485	9.3	SNAP25, TP53, ERCC2, ATM, PARP1, NCOR2
3	cytokine activity	GO:005125	9.3	IFNG, IL5, IL4, IL2, IL1A, IL15
4	enzyme binding	GO:019899	7.9	POLB, PRKDC, STAT1, H2AFX, PLAUR, NR5A1
5	identical protein binding	GO:042802	7.7	FAS, CAD, ESR1, TP53, TP63, MDM2
6	protein binding	GO:005515	1.6	GDI1, NR1H2, TBXA2R, PTPRC, TMPO, TP63