MCID: TCL003
MIFTS: 52

T Cell Deficiency malady

Immune diseases category

Summaries for T Cell Deficiency

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63Wikipedia, 32MalaCards
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Wikipedia:63 T cell deficiency is a deficiency of T cells, either caused by lymphocytopenia of T cells or by... more...

MalaCards: T Cell Deficiency, also known as t-lymphocyte deficiency, is related to thyroiditis and autoimmune hemolytic anemia. An important gene associated with T Cell Deficiency is IGLL1 (immunoglobulin lambda-like polypeptide 1), and among its related pathways are Akt Signaling and TGF-Beta Pathway. The compounds histamine and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for T Cell Deficiency

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

t cell deficiency 8 10
t-lymphocyte deficiency 60


External Ids:

Disease Ontology8 DOID:11200
NCIt39 C27872

Related Diseases for T Cell Deficiency

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17GeneCards, 18GeneDecks
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Diseases related to T Cell Deficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 205)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.3CD79A
2autoimmune hemolytic anemia30.2CD79A
3graves' disease30.0ICAM1, IL4
4pneumonia30.0CCL7, ICAM1, BTK, CD79A, IL5
5leukemia30.0CCL7, ICAM1, BTK, CD79A, IL4, TEC
6candidiasis30.0CD79A
7vasculitis30.0CD79A, ICAM1
8tuberculosis30.0CCL7, CD79A, IL4
9arthritis30.0IL4, ICAM1
10cryoglobulinemia30.0CD79A
11alopecia areata29.9ICAM1
12hepatitis b29.9CD79A
13systemic lupus erythematosus29.9ICAM1, TNFRSF13C, CD79A, IL4
14b cell deficiency10.4
15graft versus host disease10.2
16common variable immunodeficiency10.2
17t lymphocyte deficiency10.2
18hepatitis10.2
19severe combined immunodeficiency10.2
20progressive multifocal leukoencephalopathy10.2
21nezelof syndrome10.2
22immune defect due to absence of thymus10.2
23deficiency anemia10.1
24ataxia telangiectasia10.1
25digeorge syndrome10.1
26gamma chain deficiency10.1
27hepatitis a10.1
28hemolytic anemia10.1
29multiple sclerosis10.1
30vaccinia10.0
31down syndrome10.0
32allergic asthma10.0CCL7, ICAM1, IGHE, MUC5AC, IL5, IL4
33rhinitis10.0CCL7, ICAM1, IGHE, CD79A, IL5, IL4
34eosinophilia10.0CCL7, IGHE, CD79A, IL5, IL4
35sinusitis10.0IL5, CD79A, BTK, IGHE
36food allergy10.0IL4, IL5, IGHE, SCP2
37otitis media10.0CD79A, MUC5AC, IGHE
38adenoma10.0TP63, KRT13, KRT19, MUC4, MUC5AC
39immunodeficiency with hyper igm type 110.0IGHE, BTK, CD79A, IL4
40lichen planus10.0KRT13, ICAM1
41common variable immune deficiency10.0TNFRSF13C, BTK, CD79A, IL4
42mucoepidermoid carcinoma10.0MUC5AC, MUC4, KRT13, TP63
43squamous cell carcinoma10.0SFN, MUC5AC, MUC4, KRT19, KRT13, KRT3
44cicatricial pemphigoid10.0KRT3
45skin disease10.0ICAM1, IGHE, CD79A, IL5, IL4, TP63
46adenosquamous carcinoma10.0MUC5AC, MUC4, KRT19, TP63
47keratoconjunctivitis10.0IL5
48cystic fibrosis10.0KRT13, MUC4, MUC5AC
49allergic rhinitis10.0IL4, IL5, IGHE, ICAM1
50bronchiolitis10.0IL5, IGHE

Graphical network of the top 20 diseases related to T Cell Deficiency:



Diseases related to t cell deficiency

Clinical Features for T Cell Deficiency

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Drugs & Therapeutics for T Cell Deficiency

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for T Cell Deficiency

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Anatomical Context for T Cell Deficiency

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32MalaCards
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MalaCards organs/tissues related to T Cell Deficiency:

32
T cells, B cells, Bone, Bone marrow, Skin, Thymus, Nk cells, Lung, Liver, Brain, Spleen, Small intestine, Monocytes, Thyroid, Heart, Lymph node, Testes

Animal Models for T Cell Deficiency or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to T Cell Deficiency:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.7TP63, CCL7, SFN, ICAM1, TNFRSF13C, SCP2
2MP:000539710.7CCL7, SFN, ICAM1, TNFRSF13C, IGHE, IGLL1
3MP:000537610.6TNFRSF13C, SCP2, IGHE, MUC5AC, BTK, CD79A
4MP:000538110.5SFN, ICAM1, MUC5AC, BTK, MCM4, IL5
5MP:000538410.5SFN, TNFRSF13C, IGLL1, BTK, CD79A, MCM4
6MP:000200610.2SFN, ICAM1, BTK, MCM4, IL5, KRT19

Publications for T Cell Deficiency

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50PubMed
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Articles related to T Cell Deficiency:

(show top 50)    (show all 337)
idTitleAuthorsYear
1
IP Chain-associated protein of 70 kDa (ZAP70) deficiency in human subjects is associated with abnormalities of thymic stromal cells: Implications for T-cell tolerance. (23245794)
2013
2
Effects of postchallenge administration of ST-246 on dissemination of IHD-J-Luc vaccinia virus in normal mice and in immune-deficient mice reconstituted with T cells. (23468500)
2013
3
The protective effects of T cell deficiency against brain injury are ischemic model-dependent in rats. (23228347)
2013
4
Antibody deficiency in patients with ataxia telangiectasia is caused by disturbed B- and T-cell homeostasis and reduced immune repertoire diversity. (23566627)
2013
5
NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells. (22412192)
2012
6
IFN-I^ receptor-deficient donor T cells mediate protection from graft-versus-host disease and preserve graft-versus-tumor responses after allogeneic bone marrow transplantation. (22778394)
2012
7
Experimental myasthenia gravis in Aire-deficient mice: a link between Aire and regulatory T cells. (23278585)
2012
8
Functional T-cell deficiency in adolescents who experience serogroup C meningococcal disease despite receiving the meningococcal serogroup C conjugate vaccine. (20463106)
2010
9
Gamma(c) deficiency precludes CD8+ T cell memory despite formation of potent T cell effectors. (20439728)
2010
10
CD20 deficiency in humans results in impaired T cell-independent antibody responses. (20038800)
2010
11
Patients with Wegener's granulomatosis demonstrate a relative deficiency and functional impairment of T-regulatory cells. (20113371)
2010
12
Can T-cell deficiency affect spatial learning ability following toluene exposure? (19923859)
2010
13
Common variable immunodeficiency with regulatory T-cell deficiency treated with rapamycin. (19230472)
2009
14
CXCR3 deficiency increases susceptibility to genital herpes simplex virus type 2 infection: Uncoupling of CD8+ T-cell effector function but not migration. (19587047)
2009
15
Late-onset combined immune deficiency: a subset of common variable immunodeficiency with severe T cell defect. (19807277)
2009
16
Deficiency in regulatory T cells results in development of antimitochondrial antibodies and autoimmune cholangitis. (19065675)
2009
17
The effects of T cell deficiency on the development of worms and granuloma formation in mice infected with Schistosoma japonicum. (18246371)
2008
18
Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and T cell responses are unaffected by immunoproteasome deficiency. (17964666)
2007
19
Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells. (17403934)
2007
20
Wip1 phosphatase-deficient mice exhibit defective T cell maturation due to sustained p53 activation. (16585576)
2006
21
Mucosal FOXP3+ regulatory T cells are numerically deficient in acute and chronic GvHD. (16278306)
2006
22
Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder. (16157684)
2005
23
IL-23 and IFN-gamma deficiency in immunodeficient HIV patients who achieved a long-term increase in CD4 T-cell counts on highly active antiretroviral therapy. (15362668)
2004
24
Impaired accumulation and function of memory CD4 T cells in human IL-12 receptor beta 1 deficiency. (12496448)
2003
25
Successful immunosuppressive therapy with cyclosporine A for posthepatitis B-cell deficiency with activated cytoplasmic interferon--gamma-positive T-lymphocytes. (11999357)
2002
26
Survival and clonal expansion of mutating "forbidden" (immunoglobulin receptor-deficient) epstein-barr virus-infected b cells in angioimmunoblastic t cell lymphoma. (11581315)
2001
27
Production of functionally deficient dendritic cells from HTLV-I-infected monocytes: implications for the dendritic cell defect in adult T cell leukemia. (10936095)
2000
28
Experimental autoimmune encephalomyelitis in NF-kappa B-deficient mice:roles of NF-kappa B in the activation and differentiation of autoreactive T cells. (10453042)
1999
29
Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice. (9642684)
1998
30
Construction of retroviral vectors carrying human CD3 gamma cDNA and reconstitution of CD3 gamma expression and T cell receptor surface expression and function in a CD3 gamma-deficient mutant T cell line. (9189762)
1997
31
Phenotypic features of selective T cell deficiency characterized by absence of CD8+ T lymphocytes and undetectable mRNA for ZAP-70 kinase. (9245543)
1997
32
Alloantibody- and T cell-mediated immunity in the pathogenesis of transplant arteriosclerosis: lack of progression to sclerotic lesions in B cell-deficient mice. (9415552)
1997
33
Severe combined immunodeficiency with absence of peripheral blood CD8+ T cells due to ZAP-70 deficiency. (7671314)
1995
34
Reduced IL-2 expression upon antigen stimulation is accompanied by deficient IL-9 gene expression in T cells of patients with CVID. (7871381)
1995
35
Surface expression of a heterologous phosphatase complements CD45 deficiency in a T cell clone. (7931069)
1994
36
T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines. (1385777)
1992
37
Correction of purine nucleoside phosphorylase deficiency by retroviral-mediated gene transfer in mouse S49 T cell lymphoma: a model for gene therapy of T cell immunodeficiency. (1482702)
1992
38
Adult T-cell leukaemia in patients with OKT4 epitope deficiency. (1722995)
1991
39
Human immunodeficiency virus (HIV) infection in CD4+ T lymphocytes genetically deficient in LFA-1: LFA-1 is required for HIV-mediated cell fusion but not for viral transmission. (1671082)
1991
40
Analysis of the peripheral T-cell compartment in the MHC class II deficiency syndrome. (1796210)
1991
41
Severe duodenal candidiasis in a patient with IgA deficiency and T cell defects. (2307508)
1990
42
Lissencephaly, abnormal lymph nodes, and T-cell deficiency in one patient. (2596499)
1989
43
Preservation of natural killer and interleukin-2 activated killer cell activity in ataxia-telangiectasia with T cell deficiency. (3497277)
1987
44
Experimental pyelonephritis. The effect of T-cell deficiency on the course of hematogenous enterococcal pyelonephritis in the mouse. (6424480)
1984
45
Prenatal diagnosis of three cases of severe combined immunodeficiency: severe T cell deficiency during the first half of gestation in fetuses with adenosine deaminase deficiency. (6610509)
1984
46
Combined neutrophil and T-cell deficiency: initial report of a kindred with features of the hyper-IgE syndrome and chronic granulomatous disease. (6979928)
1982
47
Transient hypocalcaemia and T-cell deficiency in an infant. (300643)
1977
48
Idiopathic late-onset immunoglobulin deficiency with functional T-cell deficiency. (1083220)
1976
49
Report of a patient with T-cell deficiency and normal B-cell function: a new immunodeficiency disease with response to transfer factor. (1081434)
1975
50
Successful thymus graft for T-cell deficiency in a 6-year-old boy. (1078636)
1975

Genetic Variations for T Cell Deficiency

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Expression for genes affiliated with T Cell Deficiency

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with T Cell Deficiency

Search GEO for disease gene expression data for T Cell Deficiency.

Pathways for genes affiliated with T Cell Deficiency

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51QIAGEN, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome, 52R&D Systems
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Pathways related to T Cell Deficiency according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5CCL7, TNFRSF13C, BTK, IL5, IL4, TEC
2
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10.5CCL7, TNFRSF13C, BTK, IL5, IL4
3
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10.5CCL7, TNFRSF13C, BTK, IL5, IL4
410.5CD79A, BTK, IGLL1, TNFRSF13C
5
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10.5ICAM1, IGHE, BTK, CD79A, IL5, IL4
6
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10.5ICAM1, TNFRSF13C, IL5, IL4
7
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10.5BTK, CD79A, IL5, IL4, TEC
810.5BTK, TNFRSF13C, ICAM1
910.5ICAM1, BTK, IL5
1010.5SFN, ICAM1, IL5, IL4
11
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10.5TEC, IL4, CD79A, BTK
1210.5BTK, CD79A, IL4, TEC
13
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10.5TEC, CD79A, BTK, IGHE
14
Immune response NFAT in immune response
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10.5CD79A, BTK, IGHE
1510.5IL4, IL5, IGHE
1610.5IL4, IL5

Compounds for genes affiliated with T Cell Deficiency

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44Novoseek, 28IUPHAR, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to T Cell Deficiency according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1histamine44 28 2413.0IL4, CCL7, ICAM1, IGHE, MUC5AC, BTK
2retinoic acid44 2412.0ICAM1, IGHE, MUC5AC, MUC4, CD79A, IL5
3dexamethasone44 49 28 1114.0CCL7, ICAM1, IGHE, MUC5AC, MUC4, CD79A
4tarc4411.0IL4, IL5, IGHE, ICAM1, CCL7
5paraffin4411.0MUC5AC, CD79A, IL5, IL4, KRT19, KRT13
6methacholine44 1112.0ICAM1, IGHE, CD79A, IL5, IL4
7tyrosine4411.0CCL7, ICAM1, MUC5AC, MUC4, BTK, IL5
8sodium cromoglycate4411.0IL5, CD79A, IGHE, ICAM1
9allergens4411.0SCP2, IGHE, CD79A, IL5, IL4
10nedocromil sodium4411.0ICAM1, IGHE, IL5, IL4
11praziquantel44 1111.9IL4, IL5, CD79A, IGHE
12azelastine44 1111.9ICAM1, IGHE, IL5, IL4
13ivig4410.9IGHE, BTK, CD79A
14testosterone44 59 11 2413.9SCP2, IGHE, MUC5AC, CD79A, IL5, KRT19
15unicap4410.9IGHE, CD79A, IL5
16budesonide44 49 1112.9IL4, IL5, IGHE, ICAM1
17omalizumab44 1111.9IGHE, IL5, IL4
18oxatomide4410.9ICAM1, IGHE, IL5
19calcium44 49 11 2413.9CCL7, SFN, TNFRSF13C, MUC5AC, MUC4, BTK
20arginine4410.9IGHE, BTK, CD79A, IL5, IL4, KRT3
21cyclosporin a44 28 5912.9ICAM1, IGHE, CD79A, IL5, IL4, TEC
22toluene diisocyanate4410.9IGHE, IL5, KRT19
23desloratadine44 1111.9IL4, IGHE, ICAM1
24ovomucoid4410.9IGHE
25cetirizine44 28 11 2413.9IL5, IGHE, ICAM1
26vegf4410.9TP63, KRT19, IL5, CD79A
27ketotifen44 1111.9ICAM1, IGHE, IL5
28penicillin4410.9IGHE, CD79A, IL5
29n acetylcysteine4410.9ICAM1, IGHE, MUC5AC, CD79A, IL4
30sb 20358044 5911.9ICAM1, MUC5AC, BTK, IL5, IL4
31itraconazole44 1111.9IL4, IL5, IGHE
32cycloheximide4410.8CCL7, ICAM1, IGHE, IL5, IL4, KRT19
33montelukast44 49 28 1113.8IL4, IL5, IGHE
34fibrinogen4410.8ICAM1, BTK, CD79A, KRT19, TEC
35okt34410.8IL4, CD79A, ICAM1
36tolnaftate4410.8IL5, IL4
37loteprednol44 1111.8IL5, IL4
38con a4410.8CD79A, IL5, IL4
39gm-csf44 2811.8ICAM1, IL5, IL4
40bromodeoxyuridine4410.8TP63, KRT3, KRT19, BTK
41salbutamol44 49 28 11 2414.7IGHE, CD79A, IL5
42fluticasone propionate44 49 59 1113.7IL4, IL5, IGHE
43thyroxine44 2411.7IGHE, CD79A, IL5, IL4
44steroid4410.7TP63, KRT19, CD79A, MUC4, MUC5AC, SCP2
45mometasone44 1111.6IL5, IL4
46proline4410.6TEC, KRT3, KRT13, BTK, MUC5AC
47phosphatidylinositol4410.5ICAM1, SCP2, MUC5AC, MUC4, BTK, TEC
48levocabastine44 28 1112.5IL5, ICAM1
49carbamazepine44 49 1112.4IL4, IL5, CD79A
50methotrexate44 49 1112.2IGHE, MUC5AC, CD79A, IL5

GO Terms for genes affiliated with T Cell Deficiency

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16Gene Ontology
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Cellular components related to T Cell Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.5IL4, CD79A, TNFRSF13C, ICAM1

Biological processes related to T Cell Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell receptor signaling pathwayGO:05085310.6TEC, CD79A, BTK
2positive regulation of B cell proliferationGO:03089010.5IL4, IL5, TNFRSF13C
3keratinocyte proliferationGO:04361610.5TP63, SFN
4B cell costimulationGO:03129610.4TNFRSF13C, IL4
5immune responseGO:00695510.2IL4, IL5, IGLL1, IGHE, CCL7

Products for genes affiliated with T Cell Deficiency

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Sources for T Cell Deficiency

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet