MCID: TCL003
MIFTS: 44

T Cell Deficiency malady

Immune diseases category

Summaries for T Cell Deficiency

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66Wikipedia, 34MalaCards
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Wikipedia:66 T cell deficiency is a deficiency of T cells, either caused by lymphocytopenia of T cells or by... more...

MalaCards: T Cell Deficiency, also known as t-lymphocyte deficiency, is related to severe combined immunodeficiency and graft versus host disease. An important gene associated with T Cell Deficiency is SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1), and among its related pathways are ICos-ICosL Pathway in T-Helper Cell and Lymphocyte Signaling. The compounds ctla4-ig and alpha-galactosylceramide have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for T Cell Deficiency

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63UMLS, 9Disease Ontology, 11DISEASES, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

t cell deficiency 9 11
t-lymphocyte deficiency 63


External Ids:

Disease Ontology9 DOID:11200
NCIt41 C27872

Related Diseases for T Cell Deficiency

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18GeneCards, 19GeneDecks
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Diseases related to T Cell Deficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1severe combined immunodeficiency30.3IL15, IL2, PTPRC
2graft versus host disease30.1IL15, IL2
3hepatitis c30.0IL2, PTPRC
4nephrotic syndrome30.0SMARCAL1, PTPRC
5systemic lupus erythematosus29.9PTPRC, IL2, IL15
6multiple sclerosis29.9PTPRC, IL2, IL15
7t-cell leukemia29.9IL2, PTPRC
8leukemia29.9IL15, IL2, PTPRC
9common variable immunodeficiency10.3
10hepatitis10.3
11autoimmune hemolytic anemia10.2
12ataxia telangiectasia10.2
13digeorge syndrome10.2
14hemolytic anemia10.2
15hyper ige syndrome10.2
16immunodeficiency 7, tcr-alpha/beta deficient10.2
17tropical spastic paraparesis10.0IL15, IL2
18sezary's disease10.0IL15, IL2
19acute graft versus host disease10.0IL15, IL2
20gamma chain deficiency10.0IL15, IL2
21mycosis fungoides10.0IL2, IL15
22myasthenia gravis10.0IL15, IL2
23lymphopenia10.0IL15, IL2
24cutaneous t cell lymphoma10.0IL2, IL15
25molluscum contagiosum10.0
26cryoglobulinemia10.0
27reticular dysgenesis10.0
28charge syndrome10.0
29rheumatic heart disease10.0
30lepromatous leprosy10.0
31glucose intolerance10.0
32chronic mucocutaneous candidiasis10.0
33hepatitis b10.0
34listeriosis10.0
35chronic granulomatous disease10.0
36hypoparathyroidism10.0
37adenosine deaminase deficiency10.0
38lissencephaly10.0
39wegener's granulomatosis10.0
40adult t-cell leukemia10.0
41immune-complex glomerulonephritis10.0
42fabry disease10.0
43sclerosing cholangitis10.0
44adult-onset still's disease10.0
45alopecia10.0
46alopecia areata10.0
47arthritis10.0
48candidiasis10.0
49cataract10.0
50cholangitis10.0

Graphical network of the top 20 diseases related to T Cell Deficiency:



Diseases related to t cell deficiency

Symptoms for T Cell Deficiency

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Drugs & Therapeutics for T Cell Deficiency

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for T Cell Deficiency

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Anatomical Context for T Cell Deficiency

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34MalaCards
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MalaCards organs/tissues related to T Cell Deficiency:

34
T cells, B cells, Bone, Bone marrow, Thymus, Liver, Lymph node, Testes, Skin, Lung, Spleen, Heart, Brain, Small intestine

Animal Models for T Cell Deficiency or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to T Cell Deficiency:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.1SMARCAL1, PTPRC, IL2, IL15, HNRNPLL, ZBTB1
2MP:00053976.8HNRNPLL, IL15, IL2, PTPRC, SMARCAL1, ZBTB1

Publications for T Cell Deficiency

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53PubMed
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Articles related to T Cell Deficiency:

(show top 50)    (show all 105)
idTitleAuthorsYear
1
Impaired spatial memory in mice lacking CD3IP is associated with altered NMDA and AMPA receptors signaling independent of T-cell deficiency. (24259588)
2013
2
The protective effects of T cell deficiency against brain injury are ischemic model-dependent in rats. (23228347)
2013
3
Combined B- and T-cell deficiency does not protect against obesity-induced glucose intolerance and inflammation. (23478176)
2013
4
CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis. (22312480)
2012
5
Natural killer T cell deficiency in active adult-onset Still's Disease: correlation of deficiency of natural killer T cells with dysfunction of natural killer cells. (22605480)
2012
6
Enzyme replacement therapy partially prevents invariant Natural Killer T cell deficiency in the Fabry disease mouse model. (22425450)
2012
7
T cell deficiency does not reduce lesions in mice produced by intracerebral injection of NMO-IgG and complement. (21492943)
2011
8
CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells. (22006994)
2011
9
Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses. (20548030)
2010
10
A multiplex immunoassay using the Guthrie specimen to detect T-cell deficiencies including severe combined immunodeficiency disease. (20660143)
2010
11
Lung metastasis fails in MMTV-PyMT oncomice lacking S100A4 due to a T-cell deficiency in primary tumors. (20103644)
2010
12
Profound invariant natural killer T-cell deficiency in inflammatory arthritis. (20444757)
2010
13
Functional T-cell deficiency in adolescents who experience serogroup C meningococcal disease despite receiving the meningococcal serogroup C conjugate vaccine. (20463106)
2010
14
Hematopoietic stem cell transplantation for profound T-cell deficiency (combined immunodeficiency). (20493397)
2010
15
Newborn screening for T-cell deficiency. (20864885)
2010
16
Common variable immunodeficiency with regulatory T-cell deficiency treated with rapamycin. (19230472)
2009
17
Invariant natural killer (iNK) T cell deficiency in patients with common variable immunodeficiency. (19664144)
2009
18
The effects of T cell deficiency on the development of worms and granuloma formation in mice infected with Schistosoma japonicum. (18246371)
2008
19
Generating functional CD8+ T cell memory response under transient CD4+ T cell deficiency: implications for vaccination of immunocompromised individuals. (18506880)
2008
20
NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis. (17082625)
2006
21
Long-lasting CD3+ T-cell deficiency after cord blood stem cell transplantation in a human herpesvirus 6-infected child. (15815044)
2005
22
Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding. (15153499)
2004
23
T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions. (15141078)
2004
24
Reduced expression of Bcl-2 in CD8+ T cells deficient in the IL-15 receptor alpha-chain. (11777964)
2002
25
Intrinsic defects in the T-cell lineage results in natural killer T-cell deficiency and the development of diabetes in the nonobese diabetic mouse. (11723051)
2001
26
Genesis of progressive T-cell deficiency owing to a single missense mutation in the common gamma chain gene. (11902333)
2001
27
Genetic control of peripheral T-cell deficiency in the cataract Shionogi (CTS) mouse linked to chromosome 7. (9435347)
1998
28
Clonal expansion of Vgamma3/Vdelta3-expressing gammadelta T cells in an HIV-1/2-negative patient with CD4 T-cell deficiency. (9029011)
1997
29
Association between alphabetaTCR+CD4-CD8- T-cell deficiency and IDDM in NOD/Lt mice. (9075796)
1997
30
Phenotypic features of selective T cell deficiency characterized by absence of CD8+ T lymphocytes and undetectable mRNA for ZAP-70 kinase. (9245543)
1997
31
Defect of thymocyte emigration in a T cell deficiency strain (CTS) of the mouse. (8871639)
1996
32
Detection of a human intracisternal retroviral particle associated with CD4+ T-cell deficiency. (1380169)
1992
33
Immunomodulation of T cell deficiency in humans by thymic humoral factor: from crude extract to synthetic thymic humoral factor-gamma 2. (2199613)
1990
34
Lissencephaly, abnormal lymph nodes, and T-cell deficiency in one patient. (2596499)
1989
35
Mechanisms of Mycobacterium leprae-specific T-cell deficiency in lepromatous leprosy. (3147697)
1988
36
Natural killer cell and cytotoxic/suppressor T cell deficiency in peripheral blood in subjects with alopecia areata. (3250436)
1988
37
Development of immunity in human severe primary T cell deficiency following haploidentical bone marrow stem cell transplantation. (2869085)
1986
38
Reconstitution of T-cell deficiency by thymic hormone or thymus transplantation therapy. (3521966)
1986
39
Reduced interferon-gamma mRNA levels in human neonates. Evidence for an intrinsic T cell deficiency independent of other genes involved in T cell activation. (3081678)
1986
40
Models of T cell deficiency in listeriosis: the effects of cortisone and cyclosporin A on normal and nude BALB/c mice. (6602835)
1983
41
Combined neutrophil and T-cell deficiency: initial report of a kindred with features of the hyper-IgE syndrome and chronic granulomatous disease. (6979928)
1982
42
Quantitation of the T cell deficiency in RFM mice with host versus graft disease. (157816)
1979
43
A patient with nucleoside phosphorylase deficiency, selective t-cell deficiency, and autoimmune hemolytic anemia. (102751)
1978
44
Severe molluscum contagiosum infection with T cell deficiency. (301746)
1977
45
Idiopathic late-onset immunoglobulin deficiency with functional T-cell deficiency. (1083220)
1976
46
Report of a patient with T-cell deficiency and normal B-cell function: a new immunodeficiency disease with response to transfer factor. (1081434)
1975
47
T-cell deficiency in patients with squamous cell cancer of the head and neck. (1101724)
1975
48
Polymyxin B reactions, IgE antibody, and T-cell deficiency. Immunochemical studies in a patient after bone marrow transplantation. (167631)
1975
49
Chronic mucocutaneous candidiasis: T cell deficiency associated with B cell dysfunction in man. (4549559)
1974
50
T cell deficiency in mouse allogeneic radiation chimeras. (4582262)
1973

Variations for T Cell Deficiency

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Expression for genes affiliated with T Cell Deficiency

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with T Cell Deficiency

Search GEO for disease gene expression data for T Cell Deficiency.

Pathways for genes affiliated with T Cell Deficiency

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Sources:
51PathCards, 54QIAGEN, 5Cell Signaling Technology, 39NCBI BioSystems Database, 31KEGG, 55R&D Systems, 61Thomson Reuters
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Pathways related to T Cell Deficiency according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5PTPRC, IL2
29.5PTPRC, IL2
3
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.5PTPRC, IL2
4
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.4IL15, IL2
5
Show member pathways
Type III interferon signaling39
9.4IL2, IL15
6
Show member pathways
9.4IL15, IL2
79.4IL15, IL2
89.4IL2, IL15
9
Show member pathways
9.0SMARCAL1, IL15, IL2
10
Show member pathways
9.0PTPRC, IL2, IL15

Compounds for genes affiliated with T Cell Deficiency

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46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 3BitterDB, 62Tocris Bioscience, 25HMDB
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Compounds related to T Cell Deficiency according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1ctla4-ig469.8IL15, IL2
2alpha-galactosylceramide469.8IL15, IL2
3c-d4t469.8IL15, IL2
4daclizumab46 1210.8IL15, IL2
5basiliximab46 1210.8IL2, IL15
6il-12469.8IL15, IL2
7etanercept46 52 1211.8IL15, PTPRC
8okt3469.7IL2, IL15
9gm-csf46 3010.7IL15, IL2
10infliximab46 52 1211.7PTPRC, IL15
11polyinosinic-polycytidylic acid469.7IL15, IL2
12il 10469.7IL15, IL2
13rituximab46 52 1211.6IL15, IL2
14chloroquine46 3 52 30 1213.6IL2, IL15
15herbimycin a46 6210.5PTPRC, IL2
16dmso469.5IL2, PTPRC
17hydrocortisone46 3 62 1212.5IL15, IL2
18cyclophosphamide46 52 1211.3IL15, IL2
19ionomycin469.3PTPRC, IL2, IL15
20histamine46 30 2511.3IL15, IL2, PTPRC
21cyclosporin a46 30 6211.2PTPRC, IL2, IL15
22cycloheximide469.2IL15, IL2, PTPRC
23tacrolimus46 52 1211.1IL15, IL2
24dexamethasone46 52 30 1212.1IL15, IL2, PTPRC

GO Terms for genes affiliated with T Cell Deficiency

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17Gene Ontology
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Biological processes related to T Cell Deficiency according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tissue remodelingGO:0341059.6IL2, IL15
2T cell differentiationGO:0302179.5IL2, PTPRC
3positive regulation of interleukin-17 productionGO:0327409.5IL15, IL2
4positive regulation of inflammatory responseGO:0507299.4IL15, IL2
5positive regulation of B cell proliferationGO:0308909.4PTPRC, IL2
6positive regulation of natural killer cell differentiationGO:0328259.2ZBTB1, IL15
7positive regulation of T cell proliferationGO:0421029.2IL15, PTPRC

Molecular functions related to T Cell Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.4IL15, IL2

Products for genes affiliated with T Cell Deficiency

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for T Cell Deficiency

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet