MCID: TCL003
MIFTS: 44

T Cell Deficiency malady

Immune diseases category
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Summaries for T Cell Deficiency

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Wikipedia:65 T cell deficiency is a deficiency of T cells, either caused by lymphocytopenia of T cells or by... more...

MalaCards based summary: T Cell Deficiency, also known as t-lymphocyte deficiency, is related to graft versus host disease and severe combined immunodeficiency. An important gene associated with T Cell Deficiency is SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1), and among its related pathways are ICos-ICosL Pathway in T-Helper Cell and Lymphocyte Signaling. The compounds ctla4-ig and alpha-galactosylceramide have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for T Cell Deficiency

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T Cell Deficiency, Aliases & Descriptions:

Name: T Cell Deficiency 8 10
 
T-Lymphocyte Deficiency 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


External Ids:

Disease Ontology8 DOID:11200
NCIt39 C27872

Related Diseases for T Cell Deficiency

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Diseases related to T Cell Deficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 104)
idRelated DiseaseScoreTop Affiliating Genes
1graft versus host disease30.2IL15, IL2
2severe combined immunodeficiency30.1IL15, IL2, PTPRC
3hepatitis c30.0IL2, PTPRC
4systemic lupus erythematosus30.0PTPRC, IL2, IL15
5nephrotic syndrome30.0SMARCAL1, PTPRC
6multiple sclerosis30.0PTPRC, IL2, IL15
7t-cell leukemia29.7IL2, PTPRC
8leukemia29.5IL15, IL2, PTPRC
9common variable immunodeficiency10.3
10hepatitis10.3
11ataxia telangiectasia10.2
12hemolytic anemia10.2
13obesity10.2
14autoimmune hemolytic anemia10.2
15charge syndrome10.2
16digeorge syndrome10.2
17lupus erythematosus10.2
18hyper ige syndrome10.2
19immunodeficiency 7, tcr-alpha/beta deficient10.2
20tropical spastic paraparesis10.2IL15, IL2
21sezary's disease10.2IL15, IL2
22acute graft versus host disease10.2IL15, IL2
23gamma chain deficiency10.2IL15, IL2
24mycosis fungoides10.2IL2, IL15
25myasthenia gravis10.2IL15, IL2
26lymphopenia10.1IL15, IL2
27cutaneous t cell lymphoma10.1IL2, IL15
28hairy cell leukemia10.0IL2, PTPRC
29adult t-cell leukemia10.0
30alopecia10.0
31arthritis10.0
32brain injury10.0
33cataract10.0
34chronic granulomatous disease10.0
35ectodermal dysplasia10.0
36glomerulonephritis10.0
37hematopoietic stem cell transplantation10.0
38hepatitis b10.0
39hepatocellular carcinoma10.0
40schizophrenia10.0
41cryoglobulinemia10.0
42chronic mucocutaneous candidiasis10.0
43sclerosing cholangitis10.0
44adult-onset still's disease10.0
45fabry disease10.0
46adenosine deaminase deficiency10.0
47lissencephaly10.0
48wegener's granulomatosis10.0
49immune-complex glomerulonephritis10.0
50molluscum contagiosum10.0

Graphical network of the top 20 diseases related to T Cell Deficiency:



Diseases related to t cell deficiency

Symptoms for T Cell Deficiency

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Drugs & Therapeutics for T Cell Deficiency

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Drug clinical trials:

Search ClinicalTrials for T Cell Deficiency

Search NIH Clinical Center for T Cell Deficiency

Genetic Tests for T Cell Deficiency

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Anatomical Context for T Cell Deficiency

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MalaCards organs/tissues related to T Cell Deficiency:

32
T cells, B cells, Bone, Thymus, Neutrophil, Bone marrow, Liver, Lymph node, Spleen, Brain, Heart, Skeletal muscle, Small intestine, Kidney, Lung, Skin, Testes

Animal Models for T Cell Deficiency or affiliated genes

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MGI Mouse Phenotypes related to T Cell Deficiency:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.1SMARCAL1, PTPRC, IL2, IL15, HNRNPLL, ZBTB1
2MP:00053976.8HNRNPLL, IL15, IL2, PTPRC, SMARCAL1, ZBTB1

Publications for T Cell Deficiency

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Articles related to T Cell Deficiency:

(show top 50)    (show all 110)
idTitleAuthorsYear
1
Attenuated adipose tissue and skeletal muscle inflammation in obese mice with combined CD4+ and CD8+ T cell deficiency. (24530773)
2014
2
Mucosal-associated invariant T cell deficiency in systemic lupus erythematosus. (25225673)
2014
3
Impaired spatial memory in mice lacking CD3IP is associated with altered NMDA and AMPA receptors signaling independent of T-cell deficiency. (24259588)
2013
4
The protective effects of T cell deficiency against brain injury are ischemic model-dependent in rats. (23228347)
2013
5
Combined B- and T-cell deficiency does not protect against obesity-induced glucose intolerance and inflammation. (23478176)
2013
6
Fine-tuning of regulatory T cell function: the role of calcium signals and naive regulatory T cells for regulatory T cell deficiency in multiple sclerosis. (23576680)
2013
7
CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis. (22312480)
2012
8
Natural killer T cell deficiency in active adult-onset Still's Disease: correlation of deficiency of natural killer T cells with dysfunction of natural killer cells. (22605480)
2012
9
Enzyme replacement therapy partially prevents invariant Natural Killer T cell deficiency in the Fabry disease mouse model. (22425450)
2012
10
T cell deficiency does not reduce lesions in mice produced by intracerebral injection of NMO-IgG and complement. (21492943)
2011
11
CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells. (22006994)
2011
12
Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses. (20548030)
2010
13
A multiplex immunoassay using the Guthrie specimen to detect T-cell deficiencies including severe combined immunodeficiency disease. (20660143)
2010
14
Lung metastasis fails in MMTV-PyMT oncomice lacking S100A4 due to a T-cell deficiency in primary tumors. (20103644)
2010
15
Profound invariant natural killer T-cell deficiency in inflammatory arthritis. (20444757)
2010
16
Functional T-cell deficiency in adolescents who experience serogroup C meningococcal disease despite receiving the meningococcal serogroup C conjugate vaccine. (20463106)
2010
17
Common variable immunodeficiency with regulatory T-cell deficiency treated with rapamycin. (19230472)
2009
18
Invariant natural killer (iNK) T cell deficiency in patients with common variable immunodeficiency. (19664144)
2009
19
The effects of T cell deficiency on the development of worms and granuloma formation in mice infected with Schistosoma japonicum. (18246371)
2008
20
Generating functional CD8+ T cell memory response under transient CD4+ T cell deficiency: implications for vaccination of immunocompromised individuals. (18506880)
2008
21
NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis. (17082625)
2006
22
Long-lasting CD3+ T-cell deficiency after cord blood stem cell transplantation in a human herpesvirus 6-infected child. (15815044)
2005
23
Responses against complex antigens in various models of CD4 T-cell deficiency: surprises from an anti-CD4 antibody transgenic mouse. (15258307)
2004
24
Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding. (15153499)
2004
25
T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions. (15141078)
2004
26
Reduced expression of Bcl-2 in CD8+ T cells deficient in the IL-15 receptor alpha-chain. (11777964)
2002
27
Intrinsic defects in the T-cell lineage results in natural killer T-cell deficiency and the development of diabetes in the nonobese diabetic mouse. (11723051)
2001
28
Genesis of progressive T-cell deficiency owing to a single missense mutation in the common gamma chain gene. (11902333)
2001
29
Genetic control of peripheral T-cell deficiency in the cataract Shionogi (CTS) mouse linked to chromosome 7. (9435347)
1998
30
Clonal expansion of Vgamma3/Vdelta3-expressing gammadelta T cells in an HIV-1/2-negative patient with CD4 T-cell deficiency. (9029011)
1997
31
Association between alphabetaTCR+CD4-CD8- T-cell deficiency and IDDM in NOD/Lt mice. (9075796)
1997
32
Phenotypic features of selective T cell deficiency characterized by absence of CD8+ T lymphocytes and undetectable mRNA for ZAP-70 kinase. (9245543)
1997
33
Defect of thymocyte emigration in a T cell deficiency strain (CTS) of the mouse. (8871639)
1996
34
Detection of a human intracisternal retroviral particle associated with CD4+ T-cell deficiency. (1380169)
1992
35
Immunomodulation of T cell deficiency in humans by thymic humoral factor: from crude extract to synthetic thymic humoral factor-gamma 2. (2199613)
1990
36
Lissencephaly, abnormal lymph nodes, and T-cell deficiency in one patient. (2596499)
1989
37
Mechanisms of Mycobacterium leprae-specific T-cell deficiency in lepromatous leprosy. (3147697)
1988
38
Natural killer cell and cytotoxic/suppressor T cell deficiency in peripheral blood in subjects with alopecia areata. (3250436)
1988
39
Development of immunity in human severe primary T cell deficiency following haploidentical bone marrow stem cell transplantation. (2869085)
1986
40
Reconstitution of T-cell deficiency by thymic hormone or thymus transplantation therapy. (3521966)
1986
41
Models of T cell deficiency in listeriosis: the effects of cortisone and cyclosporin A on normal and nude BALB/c mice. (6602835)
1983
42
Combined neutrophil and T-cell deficiency: initial report of a kindred with features of the hyper-IgE syndrome and chronic granulomatous disease. (6979928)
1982
43
Quantitation of the T cell deficiency in RFM mice with host versus graft disease. (157816)
1979
44
A patient with nucleoside phosphorylase deficiency, selective t-cell deficiency, and autoimmune hemolytic anemia. (102751)
1978
45
Severe molluscum contagiosum infection with T cell deficiency. (301746)
1977
46
Idiopathic late-onset immunoglobulin deficiency with functional T-cell deficiency. (1083220)
1976
47
Report of a patient with T-cell deficiency and normal B-cell function: a new immunodeficiency disease with response to transfer factor. (1081434)
1975
48
T-cell deficiency in patients with squamous cell cancer of the head and neck. (1101724)
1975
49
Chronic mucocutaneous candidiasis: T cell deficiency associated with B cell dysfunction in man. (4549559)
1974
50
T cell deficiency in mouse allogeneic radiation chimeras. (4582262)
1973

Variations for T Cell Deficiency

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Expression for genes affiliated with T Cell Deficiency

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Expression patterns in normal tissues for genes affiliated with T Cell Deficiency

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Pathways for genes affiliated with T Cell Deficiency

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Pathways related to T Cell Deficiency according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5PTPRC, IL2
29.5PTPRC, IL2
3
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.5PTPRC, IL2
4
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.4IL15, IL2
5
Show member pathways
Type III interferon signaling37
9.4IL2, IL15
6
Show member pathways
9.4IL15, IL2
79.4IL15, IL2
89.4IL2, IL15
9
Show member pathways
9.0SMARCAL1, IL15, IL2
10
Show member pathways
9.0PTPRC, IL2, IL15

Compounds for genes affiliated with T Cell Deficiency

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Compounds related to T Cell Deficiency according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1ctla4-ig449.8IL15, IL2
2alpha-galactosylceramide449.8IL15, IL2
3c-d4t449.8IL15, IL2
4daclizumab44 1110.8IL15, IL2
5basiliximab44 1110.8IL2, IL15
6il-12449.8IL15, IL2
7etanercept44 50 1111.8IL15, PTPRC
8okt3449.7IL2, IL15
9gm-csf44 2810.7IL15, IL2
10infliximab44 50 1111.7PTPRC, IL15
11polyinosinic-polycytidylic acid449.7IL15, IL2
12il 10449.7IL15, IL2
13rituximab44 50 1111.6IL15, IL2
14chloroquine44 2 50 28 1113.6IL2, IL15
15herbimycin a44 6110.5PTPRC, IL2
16dmso449.5IL2, PTPRC
17hydrocortisone44 2 61 1112.5IL15, IL2
18cyclophosphamide44 50 1111.3IL15, IL2
19ionomycin449.3PTPRC, IL2, IL15
20histamine44 28 2411.3IL15, IL2, PTPRC
21cyclosporin a44 28 6111.2PTPRC, IL2, IL15
22cycloheximide449.2IL15, IL2, PTPRC
23tacrolimus44 50 1111.1IL15, IL2
24dexamethasone44 50 28 1112.1IL15, IL2, PTPRC

GO Terms for genes affiliated with T Cell Deficiency

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Biological processes related to T Cell Deficiency according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tissue remodelingGO:0341059.6IL15, IL2
2T cell differentiationGO:0302179.5PTPRC, IL2
3positive regulation of interleukin-17 productionGO:0327409.5IL15, IL2
4positive regulation of inflammatory responseGO:0507299.4IL15, IL2
5positive regulation of B cell proliferationGO:0308909.4IL2, PTPRC
6positive regulation of natural killer cell differentiationGO:0328259.2IL15, ZBTB1
7positive regulation of T cell proliferationGO:0421029.2IL15, PTPRC

Molecular functions related to T Cell Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.4IL15, IL2

Products for genes affiliated with T Cell Deficiency

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Sources for T Cell Deficiency

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet