MCID: TCL003
MIFTS: 43

T Cell Deficiency

Categories: Immune diseases

Aliases & Classifications for T Cell Deficiency

MalaCards integrated aliases for T Cell Deficiency:

Name: T Cell Deficiency 12 14
T-Lymphocyte Deficiency 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11200
NCIt 46 C27872

Summaries for T Cell Deficiency

MalaCards based summary : T Cell Deficiency, also known as t-lymphocyte deficiency, is related to severe combined immunodeficiency and combined immunodeficiency, x-linked. An important gene associated with T Cell Deficiency is CD247 (CD247 Molecule), and among its related pathways/superpathways are Akt Signaling and Phospholipase-C Pathway. The drugs alemtuzumab and Fludarabine have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related phenotypes are cellular and endocrine/exocrine gland

Wikipedia : 72 T cell deficiency is a deficiency of T cells, caused by decreased function of individual T cells, it... more...

Related Diseases for T Cell Deficiency

Diseases related to T Cell Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 severe combined immunodeficiency 29.0 IL2 IL7R PTPRC ZAP70
2 combined immunodeficiency, x-linked 28.0 CD3G IL2 IL7R PNP PTPRC ZAP70
3 t-cell receptor-alpha/beta deficiency 11.1
4 digeorge syndrome 11.1
5 schimke immunoosseous dysplasia 10.8
6 immunodeficiency due to defect in mapbp-interacting protein 10.8
7 chromosome 10p deletion 10.8
8 severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive 10.3 IL7R PTPRC
9 immunodeficiency 18 10.2 CD3G PTPRC
10 immunodeficiency 17 10.1 CD3G PTPRC
11 immunodeficiency 19 10.1 CD3G ZAP70
12 cd45 deficiency 10.1 PTPRC ZAP70
13 severe combined immunodeficiency, x-linked 10.0 IL2 IL7R
14 autoimmune lymphoproliferative syndrome 9.9 IL2 LRBA PTPRC
15 lymphopenia 9.9 CD3G IL2 IL7R
16 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8
17 mucositis 9.8
18 body mass index quantitative trait locus 11 9.7
19 body mass index quantitative trait locus 9 9.7
20 body mass index quantitative trait locus 8 9.7
21 body mass index quantitative trait locus 4 9.7
22 body mass index quantitative trait locus 10 9.7
23 body mass index quantitative trait locus 7 9.7
24 body mass index quantitative trait locus 12 9.7
25 body mass index quantitative trait locus 14 9.7
26 body mass index quantitative trait locus 18 9.7
27 common variable immunodeficiency 9.7
28 hepatitis 9.7
29 progressive multifocal leukoencephalopathy 9.7 IL2 PNP
30 multiple sclerosis 9.6
31 systemic lupus erythematosus 9.6
32 anemia, autoimmune hemolytic 9.6
33 hematopoietic stem cell transplantation 9.6
34 hemolytic anemia 9.6
35 lupus erythematosus 9.6
36 hyper ige syndrome 9.6
37 b-cell expansion with nfkb and t-cell anergy 9.6 IL2 ZAP70
38 hepatocellular carcinoma 9.5
39 cryoglobulinemia, familial mixed 9.5
40 schizophrenia 9.5
41 ataxia-telangiectasia 9.5
42 charge syndrome 9.5
43 leprosy 3 9.5
44 myeloma, multiple 9.5
45 fabry disease 9.5
46 ataxia and polyneuropathy, adult-onset 9.5
47 aging 9.5
48 pulmonary disease, chronic obstructive 9.5
49 mycobacterium tuberculosis 1 9.5
50 wegener granulomatosis 9.5

Graphical network of the top 20 diseases related to T Cell Deficiency:



Diseases related to T Cell Deficiency

Symptoms & Phenotypes for T Cell Deficiency

MGI Mouse Phenotypes related to T Cell Deficiency:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.96 PTPRC CD247 RHOH CD3G SMARCAL1 FOXN1
2 endocrine/exocrine gland MP:0005379 9.76 PTPRC CD247 RHOH CD3G ZAP70 FOXN1
3 hematopoietic system MP:0005397 9.7 PTPRC CD247 RHOH CD3G SMARCAL1 FOXN1
4 immune system MP:0005387 9.36 PTPRC CD247 RHOH CD3G SMARCAL1 FOXN1

Drugs & Therapeutics for T Cell Deficiency

Drugs for T Cell Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
alemtuzumab Approved, Investigational Phase 1, Phase 2 216503-57-0
2
Fludarabine Approved Phase 1, Phase 2 21679-14-1, 75607-67-9 30751
3 Antibodies Phase 1, Phase 2
4 Antibodies, Monoclonal Phase 1, Phase 2
5 Antimetabolites Phase 1, Phase 2
6 Antimetabolites, Antineoplastic Phase 1, Phase 2
7 Immunoglobulins Phase 1, Phase 2
8 Immunosuppressive Agents Phase 1, Phase 2
9 Acidophilus Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Allogeneic SCT Of Pts With SCID And Other Primary Immunodeficiency Disorders Terminated NCT00579137 Phase 1, Phase 2 Fludarabine
2 Safety Study of Gene Modified Donor T Cell Infusion After Stem Cell Transplant for Non-Malignant Diseases Terminated NCT02231710 Phase 1
3 Lactobacillus Plantarum as Therapy for NK-T Cell Deficiency Completed NCT00011141 Oral lactobacillus administration
4 Evaluation of HIV-Negative Patients With Low CD4+ T Lymphocyte Counts Completed NCT00001319

Search NIH Clinical Center for T Cell Deficiency

Genetic Tests for T Cell Deficiency

Anatomical Context for T Cell Deficiency

MalaCards organs/tissues related to T Cell Deficiency:

38
T Cells, B Cells, Bone, Bone Marrow, Thymus, Neutrophil, Liver

Publications for T Cell Deficiency

Articles related to T Cell Deficiency:

(show top 50) (show all 124)
# Title Authors Year
1
Correction of T cell deficiency in ZAP-70 knockout mice by simple intraperitoneal adoptive transfer of thymocytes. ( 29431868 )
2018
2
Roles of Aluminum Hydroxide and Monophosphoryl Lipid A Adjuvants in Overcoming CD4+ T Cell Deficiency To Induce Isotype-Switched IgG Antibody Responses and Protection by T-Dependent Influenza Vaccine. ( 27881702 )
2017
3
Expansion of cytotoxic CD56(bright) natural killer cells during T-cell deficiency after allogeneic hematopoietic stem cell transplantation. ( 28778795 )
2017
4
Both mucosal-associated invariant and natural killer T-cell deficiency in multiple myeloma can be countered by PD-1 inhibition. ( 28385777 )
2017
5
Peripheral invariant natural killer T cell deficiency in metabolically unhealthy but normal weight versus metabolically healthy but obese individuals. ( 28322093 )
2016
6
Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity. ( 26414901 )
2015
7
T cell deficiency in spinal cord injury: altered locomotor recovery and whole-genome transcriptional analysis. ( 26546062 )
2015
8
Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like disorder caused by loss-of-function mutations in LRBA. ( 25468195 )
2015
9
Syndrome of selective IgM deficiency with severe T cell deficiency associated with disseminated cutaneous mycobacterium avium intracellulaire infection. ( 26550546 )
2015
10
Invariant natural killer T cell deficiency leads to the development of spontaneous liver inflammation dependent on I^I'T cells in mice. ( 25791517 )
2015
11
Hypomorphic interleukin-7 receptor I+-chain mutations and T-cell deficiency: a delay in diagnosis. ( 26123418 )
2015
12
Mucosal-Associated Invariant T Cell Deficiency in Chronic Obstructive Pulmonary Disease. ( 26552490 )
2015
13
Blood dendritic cell levels associated with impaired IL-12 production and T-cell deficiency in patients with kidney disease: implications for post-transplant viral infections. ( 24963818 )
2014
14
Additional B-cell deficiency does not affect growth and angiogenesis of ectopic human endometrium in T-cell-deficient endometriosis mouse models during long-term culture. ( 25270508 )
2014
15
Attenuated adipose tissue and skeletal muscle inflammation in obese mice with combined CD4+ and CD8+ T cell deficiency. ( 24530773 )
2014
16
Interleukin-7 signalling defects in naive CD4+ T cells of HIV patients with CD4+ T-cell deficiency on antiretroviral therapy are associated with T-cell activation and senescence. ( 24499954 )
2014
17
Mucosal-associated invariant T cell deficiency in systemic lupus erythematosus. ( 25225673 )
2014
18
VI'2 T cell deficiency in granulomatosis with polyangiitis (Wegener's granulomatosis). ( 23891739 )
2013
19
Combined B- and T-cell deficiency does not protect against obesity-induced glucose intolerance and inflammation. ( 23478176 )
2013
20
The protective effects of T cell deficiency against brain injury are ischemic model-dependent in rats. ( 23228347 )
2013
21
Fine-tuning of regulatory T cell function: the role of calcium signals and naive regulatory T cells for regulatory T cell deficiency in multiple sclerosis. ( 23576680 )
2013
22
Impaired spatial memory in mice lacking CD3IP is associated with altered NMDA and AMPA receptors signaling independent of T-cell deficiency. ( 24259588 )
2013
23
Regulatory T-cell deficiency in rheumatic heart disease: a preliminary observational study. ( 23610999 )
2013
24
CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis. ( 22312480 )
2012
25
Enzyme replacement therapy partially prevents invariant Natural Killer T cell deficiency in the Fabry disease mouse model. ( 22425450 )
2012
26
Natural killer T cell deficiency in active adult-onset Still's Disease: correlation of deficiency of natural killer T cells with dysfunction of natural killer cells. ( 22605480 )
2012
27
Ruling out HIV infection when testing for severe combined immunodeficiency and other T-cell deficiencies. ( 22386446 )
2012
28
CD8 T cell deficiency impairs control of Epstein--Barr virus and worsens with age in multiple sclerosis. ( 21791511 )
2012
29
IL-15 ex vivo overcomes CD4+ T cell deficiency for the induction of human antigen-specific CD8+ T cell responses. ( 21474552 )
2011
30
CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells. ( 22006994 )
2011
31
T cell deficiency does not reduce lesions in mice produced by intracerebral injection of NMO-IgG and complement. ( 21492943 )
2011
32
Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation. ( 20505149 )
2010
33
Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses. ( 20548030 )
2010
34
Can T-cell deficiency affect spatial learning ability following toluene exposure? ( 19923859 )
2010
35
Lung metastasis fails in MMTV-PyMT oncomice lacking S100A4 due to a T-cell deficiency in primary tumors. ( 20103644 )
2010
36
Functional T-cell deficiency in adolescents who experience serogroup C meningococcal disease despite receiving the meningococcal serogroup C conjugate vaccine. ( 20463106 )
2010
37
A multiplex immunoassay using the Guthrie specimen to detect T-cell deficiencies including severe combined immunodeficiency disease. ( 20660143 )
2010
38
Hematopoietic stem cell transplantation for profound T-cell deficiency (combined immunodeficiency). ( 20493397 )
2010
39
Newborn screening for T-cell deficiency. ( 20864885 )
2010
40
Profound invariant natural killer T-cell deficiency in inflammatory arthritis. ( 20444757 )
2010
41
Common variable immunodeficiency with regulatory T-cell deficiency treated with rapamycin. ( 19230472 )
2009
42
Congenital T cell deficiency in a patient with CHARGE syndrome. ( 19187738 )
2009
43
Invariant natural killer (iNK) T cell deficiency in patients with common variable immunodeficiency. ( 19664144 )
2009
44
Reduced protection from simian immunodeficiency virus SIVmac251 infection afforded by memory CD8+ T cells induced by vaccination during CD4+ T-cell deficiency. ( 18667509 )
2008
45
Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: roles of IL-2 versus IL-15. ( 18465774 )
2008
46
Generating functional CD8+ T cell memory response under transient CD4+ T cell deficiency: implications for vaccination of immunocompromised individuals. ( 18506880 )
2008
47
Hepatitis and human bocavirus primary infection in a child with T-cell deficiency. ( 18842946 )
2008
48
The effects of T cell deficiency on the development of worms and granuloma formation in mice infected with Schistosoma japonicum. ( 18246371 )
2008
49
Adult onset of T-cell deficiency with impaired CD2 expression complicated by Rhodococcus infection: a case report. ( 17378264 )
2007
50
T cell deficiency leads to liver carcinogenesis in azoxymethane-treated rats. ( 16380649 )
2006

Variations for T Cell Deficiency

Expression for T Cell Deficiency

Search GEO for disease gene expression data for T Cell Deficiency.

Pathways for T Cell Deficiency

Pathways related to T Cell Deficiency according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.23 CD247 CD3G IL2 IL7R RHOH ZAP70
2
Show member pathways
12.89 CD247 CD3G IL2 RHOH ZAP70
3
Show member pathways
12.41 CD247 CD3G IL2 ZAP70
4
Show member pathways
12.39 CD247 CD3G IL2 PTPRC ZAP70
5
Show member pathways
12.16 CD247 CD3G PTPRC ZAP70
6
Show member pathways
12.14 CD3G PTPRC ZAP70
7
Show member pathways
11.91 CD247 CD3G IL2 ZAP70
8 11.83 IL2 IL7R PTPRC
9
Show member pathways
11.81 CD247 CD3G IL2
10 11.8 CD247 CD3G ZAP70
11
Show member pathways
11.77 CD247 CD3G IL2 PTPRC ZAP70
12 11.7 IL2 IL7R PTPRC
13 11.68 CD247 CD3G RHOH ZAP70
14 11.65 IL2 IL7R PTPRC
15 11.61 CD247 CD3G PTPRC
16
Show member pathways
11.6 CD247 CD3G
17
Show member pathways
11.6 CD247 CD3G PTPRC ZAP70
18 11.59 IL2 IL7R PTPRC
19 11.58 CD247 CD3G ZAP70
20 11.55 CD247 CD3G ZAP70
21
Show member pathways
11.49 CD247 CD3G PTPRC ZAP70
22
Show member pathways
11.46 CD247 CD3G IL2
23
Show member pathways
11.4 CD247 CD3G IL2 PTPRC ZAP70
24 11.35 CD247 CD3G ZAP70
25 11.18 CD247 CD3G
26 11.15 IL2 ZAP70
27 11.12 IL2 ZAP70
28 11.11 IL7R PTPRC ZAP70
29 11.04 CD247 IL2
30 10.94 CD247 CD3G IL2

GO Terms for T Cell Deficiency

Cellular components related to T Cell Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immunological synapse GO:0001772 9.16 RHOH ZAP70
2 alpha-beta T cell receptor complex GO:0042105 8.96 CD247 CD3G
3 T cell receptor complex GO:0042101 8.8 CD247 CD3G ZAP70

Biological processes related to T Cell Deficiency according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.78 CD247 CD3G IL2 ZAP70
2 immune response GO:0006955 9.76 IL2 IL7R PNP ZAP70
3 cell surface receptor signaling pathway GO:0007166 9.67 CD247 CD3G IL7R PTPRC
4 adaptive immune response GO:0002250 9.56 CD247 CD3G IL2 ZAP70
5 positive regulation of B cell proliferation GO:0030890 9.51 IL2 PTPRC
6 positive regulation of T cell proliferation GO:0042102 9.5 IL2 PNP PTPRC
7 B cell proliferation GO:0042100 9.49 IL7R PTPRC
8 positive regulation of T cell differentiation GO:0045582 9.43 IL2 ZAP70
9 positive regulation of alpha-beta T cell differentiation GO:0046638 9.4 PNP ZAP70
10 T cell receptor signaling pathway GO:0050852 9.26 CD247 CD3G PTPRC ZAP70
11 negative regulation of T cell mediated cytotoxicity GO:0001915 9.16 IL7R PTPRC
12 T cell differentiation GO:0030217 9.02 IL2 IL7R PTPRC RHOH ZAP70

Sources for T Cell Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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