MCID: TCL003
MIFTS: 52

T Cell Deficiency malady

Immune diseases category

Summaries for T Cell Deficiency

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 T cell deficiency is a deficiency of T cells, either caused by lymphocytopenia of T cells or by... more...

MalaCards: T Cell Deficiency, also known as t-lymphocyte deficiency, is related to thyroiditis and autoimmune hemolytic anemia. An important gene associated with T Cell Deficiency is IGLL1 (immunoglobulin lambda-like polypeptide 1), and among its related pathways are Akt Signaling and TGF-Beta Pathway. The compounds histamine and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for T Cell Deficiency

About this section
Sources:
60UMLS, 8Disease Ontology, 10DISEASES, 39NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

t cell deficiency 8 10
t-lymphocyte deficiency 60


External Ids:

Disease Ontology8 DOID:11200
NCIt39 C27872

Related Diseases for T Cell Deficiency

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to T Cell Deficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 205)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.3CD79A
2autoimmune hemolytic anemia30.2CD79A
3graves' disease30.0ICAM1, IL4
4pneumonia30.0CCL7, ICAM1, BTK, CD79A, IL5
5leukemia30.0CCL7, ICAM1, BTK, CD79A, IL4, TEC
6candidiasis30.0CD79A
7vasculitis30.0CD79A, ICAM1
8tuberculosis30.0CCL7, CD79A, IL4
9arthritis30.0IL4, ICAM1
10cryoglobulinemia30.0CD79A
11alopecia areata29.9ICAM1
12hepatitis b29.9CD79A
13systemic lupus erythematosus29.9ICAM1, TNFRSF13C, CD79A, IL4
14b cell deficiency10.4
15graft versus host disease10.2
16common variable immunodeficiency10.2
17t lymphocyte deficiency10.2
18hepatitis10.2
19severe combined immunodeficiency10.2
20progressive multifocal leukoencephalopathy10.2
21nezelof syndrome10.2
22immune defect due to absence of thymus10.2
23deficiency anemia10.1
24ataxia telangiectasia10.1
25digeorge syndrome10.1
26gamma chain deficiency10.1
27hepatitis a10.1
28hemolytic anemia10.1
29multiple sclerosis10.1
30vaccinia10.0
31down syndrome10.0
32allergic asthma10.0CCL7, ICAM1, IGHE, MUC5AC, IL5, IL4
33rhinitis10.0CCL7, ICAM1, IGHE, CD79A, IL5, IL4
34eosinophilia10.0CCL7, IGHE, CD79A, IL5, IL4
35sinusitis10.0IL5, CD79A, BTK, IGHE
36food allergy10.0IL4, IL5, IGHE, SCP2
37otitis media10.0CD79A, MUC5AC, IGHE
38adenoma10.0TP63, KRT13, KRT19, MUC4, MUC5AC
39immunodeficiency with hyper igm type 110.0IGHE, BTK, CD79A, IL4
40lichen planus10.0KRT13, ICAM1
41common variable immune deficiency10.0TNFRSF13C, BTK, CD79A, IL4
42mucoepidermoid carcinoma10.0MUC5AC, MUC4, KRT13, TP63
43squamous cell carcinoma10.0SFN, MUC5AC, MUC4, KRT19, KRT13, KRT3
44cicatricial pemphigoid10.0KRT3
45skin disease10.0ICAM1, IGHE, CD79A, IL5, IL4, TP63
46adenosquamous carcinoma10.0MUC5AC, MUC4, KRT19, TP63
47keratoconjunctivitis10.0IL5
48cystic fibrosis10.0KRT13, MUC4, MUC5AC
49allergic rhinitis10.0IL4, IL5, IGHE, ICAM1
50bronchiolitis10.0IL5, IGHE

Graphical network of the top 20 diseases related to T Cell Deficiency:



Diseases related to t cell deficiency

Clinical Features for T Cell Deficiency

About this section

Drugs & Therapeutics for T Cell Deficiency

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for T Cell Deficiency

Drug clinical trials:

Search ClinicalTrials for T Cell Deficiency

Search NIH Clinical Center for T Cell Deficiency

Search CenterWatch for T Cell Deficiency

Genetic Tests for T Cell Deficiency

About this section

Anatomical Context for T Cell Deficiency

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to T Cell Deficiency:

32
T cells, B cells, Bone, Bone marrow, Thymus, Skin, Nk cells, Liver, Lung, Brain, Spleen, Small intestine, Heart, Testes, Monocytes, Lymph node, Thyroid

Animal Models for T Cell Deficiency or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to T Cell Deficiency:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.7TP63, CCL7, SFN, ICAM1, TNFRSF13C, SCP2
2MP:000539710.7CCL7, SFN, ICAM1, TNFRSF13C, IGHE, IGLL1
3MP:000537610.6TNFRSF13C, SCP2, IGHE, MUC5AC, BTK, CD79A
4MP:000538110.5SFN, ICAM1, MUC5AC, BTK, MCM4, IL5
5MP:000538410.5SFN, TNFRSF13C, IGLL1, BTK, CD79A, MCM4
6MP:000200610.2SFN, ICAM1, BTK, MCM4, IL5, KRT19

Publications for T Cell Deficiency

About this section
Sources:
50PubMed
See all sources

Articles related to T Cell Deficiency:

(show top 50)    (show all 337)
idTitleAuthorsYear
1
EVER2 deficiency is associated with mild T-cell abnormalities. (22903682)
2013
2
T Cell-Specific Overexpression of TGFA91 Fails to Influence Atherosclerosis in ApoE-Deficient Mice. (24339930)
2013
3
T cell-independent modulation of experimental autoimmune encephalomyelitis in ADAP-deficient mice. (24101551)
2013
4
The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells. (23612073)
2013
5
CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus. (23269247)
2013
6
IL-22 deficiency in donor T cells attenuates murine acute graft-versus-host disease mortality while sparing the graft-versus-leukemia effect. (23399894)
2013
7
Natural killer T cell deficiency in active adult-onset Still's Disease: correlation of deficiency of natural killer T cells with dysfunction of natural killer cells. (22605480)
2012
8
Defective inhibition of B-cell proliferation by Wiskott-Aldrich syndrome protein-deficient regulatory T cells. (21515824)
2011
9
Deficient T Cell Receptor Excision Circles (TRECs) in autosomal recessive hyper IgE syndrome caused by DOCK8 mutation: implications for pathogenesis and potential detection by newborn screening. (21763205)
2011
10
Defective central tolerance in Aire-deficient mice is not sufficient to induce symptomatic autoimmunity during lymphopenia-induced T cell proliferation. (21352256)
2011
11
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice. (22006977)
2011
12
Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses. (20548030)
2010
13
Profound invariant natural killer T-cell deficiency in inflammatory arthritis. (20444757)
2010
14
Hematopoietic stem cell transplantation for profound T-cell deficiency (combined immunodeficiency). (20493397)
2010
15
A shift towards a T cell cytokine deficiency along with an anti-inflammatory/regulatory microenvironment may enable the synthesis of anti-FVIII inhibitors in haemophilia A patients. (20846164)
2010
16
Spontaneous T cell mediated keratoconjunctivitis in Aire-deficient mice. (19429577)
2009
17
Congenital T cell deficiency in a patient with CHARGE syndrome. (19187738)
2009
18
Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: roles of IL-2 versus IL-15. (18465774)
2008
19
Defective positive selection results in T cell lymphopenia and increased autoimmune diabetes in ADAP-deficient BDC2.5-C57BL/6 mice. (18383041)
2008
20
Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosis. (16899302)
2006
21
Cutting edge: Decreased accumulation and regulatory function of CD4+ CD25(high) T cells in human STAT5b deficiency. (16920911)
2006
22
Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells. (16914553)
2006
23
An IL-7-dependent rebound in thymic T cell output contributes to the bone loss induced by estrogen deficiency. (16267136)
2005
24
Long-lasting CD3+ T-cell deficiency after cord blood stem cell transplantation in a human herpesvirus 6-infected child. (15815044)
2005
25
Opposing effects of CXCR3 and CCR5 deficiency on CD8+ T cell-mediated inflammation in the central nervous system of virus-infected mice. (16034118)
2005
26
Responses against complex antigens in various models of CD4 T-cell deficiency: surprises from an anti-CD4 antibody transgenic mouse. (15258307)
2004
27
Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice. (15504823)
2004
28
Human T cell activation by costimulatory signal-deficient allogeneic cells induces inducible costimulator-expressing anergic T cells with regulatory cell activity. (15100277)
2004
29
Prevalence of T cell receptor zeta chain deficiency in systemic lupus erythematosus. (12587826)
2003
30
Effect of CD3delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency. (14602880)
2003
31
Reduced expression of Bcl-2 in CD8+ T cells deficient in the IL-15 receptor alpha-chain. (11777964)
2002
32
Intrinsic defects in the T-cell lineage results in natural killer T-cell deficiency and the development of diabetes in the nonobese diabetic mouse. (11723051)
2001
33
T-cell lines from 2 patients with adenosine deaminase (ADA) deficiency showed the restoration of ADA activity resulted from the reversion of an inherited mutation. (11313286)
2001
34
Genesis of progressive T-cell deficiency owing to a single missense mutation in the common gamma chain gene. (11902333)
2001
35
Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus. (11238674)
2001
36
Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation. (10958690)
2000
37
T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates. (9662367)
1998
38
Liver repopulation with xenogenic hepatocytes in B and T cell-deficient mice leads to chronic hepadnavirus infection and clonal growth of hepatocellular carcinoma. (9419372)
1998
39
Analysis of T cell receptor V beta gene expression in B cell deficient mice after experimental herpes simplex virus keratitis. (9385402)
1997
40
Effects of translation initiation factor eIF-5A on the functioning of human T-cell leukemia virus type I Rex and human immunodeficiency virus Rev inhibited trans dominantly by a Rex mutant deficient in RNA binding. (7707541)
1995
41
Cytokines as antimicrobial therapy for the T cell-deficient patient: prospects for treatment of nonviral opportunistic infections. (8274606)
1993
42
Mechanisms of Mycobacterium leprae-specific T-cell deficiency in lepromatous leprosy. (3147697)
1988
43
Autologous mixed lymphocyte reaction in man. XI. Deficiency of autologous mixed lymphocyte reaction and abnormalities of monoclonal antibody-defined T-cell subsets in chronic mucocutaneous candidiasis. (2992070)
1985
44
Macrophage response to herpes simplex encephalitis in immune competent and T cell-deficient mice. (2981247)
1985
45
Numerical and functional deficiency in T helper cells in protein energy malnutrition. (6219837)
1983
46
Lack of interleukin-2 production in a patient with OKT4+ T-cell deficiency. (6601773)
1983
47
Purine nucleoside phosphorylase deficiency: a molecular model for selective loss of T cell function. (109531)
1979
48
A patient with nucleoside phosphorylase deficiency, selective t-cell deficiency, and autoimmune hemolytic anemia. (102751)
1978
49
T-cell deficiency in immune complex glomerulonephritis. (302360)
1977
50
Thymus transplantation. Reconstitution of cellular immunity in a four-year-old patient with T-cell deficiency. (171111)
1975

Genetic Variations for T Cell Deficiency

About this section

Expression for genes affiliated with T Cell Deficiency

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with T Cell Deficiency

Search GEO for disease gene expression data for T Cell Deficiency.

Pathways for genes affiliated with T Cell Deficiency

About this section
Sources:
51QIAGEN, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome, 52R&D Systems
See all sources

Pathways related to T Cell Deficiency according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5CCL7, TNFRSF13C, BTK, IL5, IL4, TEC
2
Hide members
10.5CCL7, TNFRSF13C, BTK, IL5, IL4
3
Hide members
10.5CCL7, TNFRSF13C, BTK, IL5, IL4
410.5CD79A, BTK, IGLL1, TNFRSF13C
5
Hide members
10.5ICAM1, IGHE, BTK, CD79A, IL5, IL4
6
Hide members
10.5ICAM1, TNFRSF13C, IL5, IL4
7
Hide members
10.5BTK, CD79A, IL5, IL4, TEC
810.5BTK, TNFRSF13C, ICAM1
910.5ICAM1, BTK, IL5
1010.5SFN, ICAM1, IL5, IL4
11
Hide members
10.5TEC, IL4, CD79A, BTK
1210.5BTK, CD79A, IL4, TEC
13
Hide members
10.5TEC, CD79A, BTK, IGHE
14
Immune response NFAT in immune response
Hide members
10.5CD79A, BTK, IGHE
1510.5IL4, IL5, IGHE
1610.5IL4, IL5

Compounds for genes affiliated with T Cell Deficiency

About this section
Sources:
44Novoseek, 28IUPHAR, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
See all sources

Compounds related to T Cell Deficiency according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1histamine44 28 2413.0MUC5AC, ICAM1, CCL7, BTK, IGHE, CD79A
2retinoic acid44 2412.0ICAM1, KRT13, KRT19, IL5, CD79A, MUC4
3dexamethasone44 49 28 1114.0CCL7, MUC5AC, IGHE, MUC4, CD79A, IL5
4tarc4411.0IGHE, CCL7, IL5, IL4, ICAM1
5paraffin4411.0TP63, KRT19, IL5, MUC5AC, KRT13, CD79A
6methacholine44 1112.0IL5, IL4, CD79A, ICAM1, IGHE
7tyrosine4411.0ICAM1, KRT19, TP63, CCL7, MUC5AC, MUC4
8sodium cromoglycate4411.0CD79A, IL5, ICAM1, IGHE
9allergens4411.0SCP2, IL5, IL4, CD79A, IGHE
10nedocromil sodium4411.0ICAM1, IL5, IL4, IGHE
11praziquantel44 1111.9IGHE, CD79A, IL4, IL5
12azelastine44 1111.9ICAM1, IGHE, IL4, IL5
13ivig4410.9BTK, CD79A, IGHE
14testosterone44 59 11 2413.9IGHE, IL5, MUC5AC, CD79A, KRT19, SCP2
15unicap4410.9IL5, CD79A, IGHE
16budesonide44 49 1112.9ICAM1, IL5, IL4, IGHE
17omalizumab44 1111.9IL5, IGHE, IL4
18oxatomide4410.9IL5, IGHE, ICAM1
19calcium44 49 11 2413.9CCL7, SFN, TNFRSF13C, MUC5AC, TP63, TEC
20arginine4410.9IL4, IL5, CD79A, BTK, IGHE, TP63
21cyclosporin a44 28 5912.9ICAM1, TEC, IL4, IL5, CD79A, IGHE
22toluene diisocyanate4410.9IGHE, KRT19, IL5
23desloratadine44 1111.9IL4, IGHE, ICAM1
24ovomucoid4410.9IGHE
25cetirizine44 28 11 2413.9ICAM1, IGHE, IL5
26vegf4410.9TP63, KRT19, IL5, CD79A
27ketotifen44 1111.9ICAM1, IGHE, IL5
28penicillin4410.9CD79A, IGHE, IL5
29n acetylcysteine4410.9MUC5AC, IGHE, ICAM1, CD79A, IL4
30sb 20358044 5911.9ICAM1, IL5, IL4, BTK, MUC5AC
31itraconazole44 1111.9IL5, IL4, IGHE
32cycloheximide4410.8KRT19, IL4, IL5, CCL7, IGHE, ICAM1
33montelukast44 49 28 1113.8IL4, IGHE, IL5
34fibrinogen4410.8CD79A, BTK, ICAM1, TEC, KRT19
35okt34410.8ICAM1, CD79A, IL4
36loteprednol44 1111.8IL4, IL5
37tolnaftate4410.8IL4, IL5
38con a4410.8CD79A, IL5, IL4
39gm-csf44 2811.8IL4, IL5, ICAM1
40bromodeoxyuridine4410.8KRT3, KRT19, BTK, TP63
41salbutamol44 49 28 11 2414.7CD79A, IL5, IGHE
42fluticasone propionate44 49 59 1113.7IGHE, IL5, IL4
43thyroxine44 2411.7IGHE, IL5, CD79A, IL4
44steroid4410.7SCP2, MUC5AC, TP63, KRT19, MUC4, CD79A
45mometasone44 1111.6IL5, IL4
46proline4410.6KRT3, TEC, KRT13, BTK, MUC5AC
47phosphatidylinositol4410.5ICAM1, MUC4, SCP2, TEC, MUC5AC, BTK
48levocabastine44 28 1112.5ICAM1, IL5
49carbamazepine44 49 1112.4CD79A, IL5, IL4
50methotrexate44 49 1112.2CD79A, IGHE, IL5, MUC5AC

GO Terms for genes affiliated with T Cell Deficiency

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to T Cell Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.5IL4, CD79A, TNFRSF13C, ICAM1

Biological processes related to T Cell Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell receptor signaling pathwayGO:05085310.6TEC, CD79A, BTK
2positive regulation of B cell proliferationGO:03089010.5IL4, IL5, TNFRSF13C
3keratinocyte proliferationGO:04361610.5TP63, SFN
4B cell costimulationGO:03129610.4TNFRSF13C, IL4
5immune responseGO:00695510.2IL4, IL5, IGLL1, IGHE, CCL7

Products for genes affiliated with T Cell Deficiency

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for T Cell Deficiency

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet