MCID: TCL003
MIFTS: 45

T Cell Deficiency malady

Categories: Immune diseases

Aliases & Classifications for T Cell Deficiency

Aliases & Descriptions for T Cell Deficiency:

Name: T Cell Deficiency 12 14
T-Lymphocyte Deficiency 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11200
NCIt 47 C27872
UMLS 69 C1333147

Summaries for T Cell Deficiency

MalaCards based summary : T Cell Deficiency, also known as t-lymphocyte deficiency, is related to digeorge syndrome and immunodeficiency 7, tcr-alpha/beta deficient. An important gene associated with T Cell Deficiency is CD247 (CD247 Molecule), and among its related pathways/superpathways are Allograft rejection and T cell receptor signaling pathway. The drugs Mycophenolate mofetil and Mycophenolic acid have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related phenotypes are cellular and hematopoietic system

Wikipedia : 71 T cell deficiency is a deficiency of T cells, caused by decreased function of individual T cells, it... more...

Related Diseases for T Cell Deficiency

Diseases related to T Cell Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
id Related Disease Score Top Affiliating Genes
1 digeorge syndrome 11.1
2 immunodeficiency 7, tcr-alpha/beta deficient 11.0
3 immunodeficiency due to defect in mapbp-interacting protein 10.7
4 retinitis pigmentosa-12, autosomal recessive 10.3 IL7R PTPRC
5 deep dermatophytosis 10.2 IL15 LRBA
6 single ventricular heart 10.1 IL15 IL7R PTPRC
7 ectopic thymus 10.1 IL15 IL7R
8 alcoholic pancreatitis 10.0 CD4 CD8A
9 orbital disease 10.0 CD4 CD8A
10 colloid adenoma 9.9 CD4 CD8A
11 retinal microaneurysm 9.9 CD4 CD8A
12 scrotum melanoma 9.9 CD4 CD8A
13 cervix melanoma 9.9 CD4 CD8A
14 coronin-1a deficiency 9.9 CD4 CD8A
15 scrotum squamous cell carcinoma 9.9 CD4 CD8A
16 eczema herpeticum 9.9 CD4 CD8A
17 infundibulocystic basal cell carcinoma 9.9 CD4 CD8A
18 omodysplasia 2 9.9 CD4 PTPRC
19 mixed germ cell cancer 9.9 CD4 CD8A
20 plasmacytic leukemia 9.9 CD4 CD8A
21 cataract 17, multiple types 9.9 DGCR6 NKX2-6 TBX1
22 vestibule of mouth cancer 9.9 CD4 CD8A
23 autoimmune polyendocrine syndrome type 1 9.9 CD4 CD8A
24 exophthalmos 9.9 CD4 IL15 IL7R
25 non-suppurative otitis media 9.9 CD4 CD8A
26 human immunodeficiency virus infectious disease 9.9 CD4 CD8A
27 cerebrum cancer 9.9 CD4 CD8A
28 herpetic whitlow 9.9 CD4 CD8A
29 dysentery 9.9 CD4 CD8A
30 dysplastic nevus syndrome 9.9 CD4 CD8A
31 lambda 5 deficiency 9.8 CD4 CD8A PTPRC
32 sensory organ benign neoplasm 9.8 CD4 CD8A PTPRC
33 rectum lymphoma 9.8 CD4 CD8A PTPRC
34 extragonadal seminoma 9.8 CD4 CD8A
35 cd3epsilon deficiency 9.8 CD4 CD8A PTPRC
36 abducens nerve disease 9.8 CD4 CD8A
37 squamous cell papilloma of skin 9.8 CD4 CD8A IL15
38 autoimmune disease of skin and connective tissue 9.8 CD4 CD8A IL15
39 multiple carboxylase deficiency 9.8 CD4 CD8A IL15
40 neuropathy, hereditary thermosensitive 9.8 CD4 CD8A SMARCAL1
41 lymphocytic gastritis 9.8 CD4 IL15
42 congenital hypothyroidism 9.8 CD4 CD8A
43 mucositis 9.7
44 common variable immunodeficiency 9.7
45 hepatitis 9.7
46 severe combined immunodeficiency 9.7
47 systemic lupus erythematosus 9.6
48 hyper ige syndrome 9.6
49 obesity 9.6
50 hemolytic anemia 9.6

Graphical network of the top 20 diseases related to T Cell Deficiency:



Diseases related to T Cell Deficiency

Symptoms & Phenotypes for T Cell Deficiency

MGI Mouse Phenotypes related to T Cell Deficiency:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 TBX1 CD247 CD4 CD8A IL7R LAMTOR2
2 hematopoietic system MP:0005397 9.96 CD247 CD4 CD8A HNRNPLL IL15 IL7R
3 endocrine/exocrine gland MP:0005379 9.87 CD247 CD4 CD8A IL15 IL7R PTPRC
4 immune system MP:0005387 9.85 CD247 CD4 CD8A HNRNPLL IL15 IL7R
5 mortality/aging MP:0010768 9.61 CD247 CD4 CD8A IL15 LAMTOR2 NKX2-6
6 normal MP:0002873 9.17 CD247 CD4 CD8A IL7R NKX2-6 PTPRC

Drugs & Therapeutics for T Cell Deficiency

Drugs for T Cell Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 539)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
2
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
3
Emtricitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 143491-57-0 60877
4
Lopinavir Approved Phase 4,Phase 3,Phase 2 192725-17-0 92727
5
Ritonavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 155213-67-5 392622
6
Tenofovir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147127-20-6 464205
7
Selenium Approved, Vet_approved Phase 4 7782-49-2
8
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
9
Ribavirin Approved Phase 4,Phase 3,Phase 2,Phase 1 36791-04-5 37542
10
Darunavir Approved Phase 4,Phase 3,Phase 2,Phase 1 635728-49-3, 206361-99-1 213039
11
Lamivudine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 134678-17-4 60825
12
Zidovudine Approved Phase 4,Phase 3,Phase 2,Phase 1 30516-87-1 35370
13
Nevirapine Approved Phase 4,Phase 3,Phase 2,Phase 1 129618-40-2 4463
14
Didanosine Approved Phase 4,Phase 3,Phase 2,Phase 1 69655-05-6 50599
15
Enfuvirtide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 159519-65-0 16130199
16
Etravirine Approved Phase 4,Phase 2 269055-15-4 193962
17
Efavirenz Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 154598-52-4 64139
18
Aminosalicylic Acid Approved Phase 4 65-49-6 4649
19
Ganciclovir Approved, Investigational Phase 4,Phase 3 82410-32-0 3454
20
Valganciclovir Approved, Investigational Phase 4 175865-60-8 64147
21
Maraviroc Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 376348-65-1 3002977
22
Tipranavir Approved, Investigational Phase 4,Phase 1,Phase 2 174484-41-4 65027
23
Altretamine Approved Phase 4 645-05-6 2123
24
Abacavir Approved, Investigational Phase 4,Phase 3,Phase 2 136470-78-5 65140 441300
25
Indinavir Approved Phase 4,Phase 3,Phase 2,Phase 1 150378-17-9 5362440
26
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
27
Saquinavir Approved, Investigational Phase 4 127779-20-8 60787
28
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
29
Ethambutol Approved Phase 4,Phase 2,Phase 3 74-55-5 3279 14052
30
Isoniazid Approved Phase 4,Phase 2,Phase 3 54-85-3 3767
31
Pyrazinamide Approved Phase 4 98-96-4 1046
32
Rifampin Approved Phase 4,Phase 2,Phase 3 13292-46-1 5458213 5381226
33
Stavudine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 3056-17-5 18283
34
Amprenavir Approved Phase 4,Phase 2 161814-49-9 65016
35
Nelfinavir Approved Phase 4,Phase 3,Phase 2 159989-64-7 64143
36
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
37 Dolutegravir Approved Phase 4,Phase 3,Phase 2 1051375-16-6 54726191
38
Cobicistat Approved Phase 4,Phase 3,Phase 2 1004316-88-4
39
Diflunisal Approved Phase 4 22494-42-4 3059
40
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 67-97-0 6221 10883523 5280795
41
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-14-6 5280793
42
Pyridoxal Approved, Nutraceutical Phase 4 66-72-8 1050
43
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
44 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2
45 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
46 Anti-HIV Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
47 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
48 Anti-Retroviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
49 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
50 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 843)
id Name Status NCT ID Phase
1 Mycophenolate Mofetil in Antiretroviral Naïve Patients 2 (MAN2 Study) Unknown status NCT00120419 Phase 4
2 Immune Reconstitution as a Determinant of Adverse Effects to New Antiretroviral Therapy in Persons With Advanced HIV Infection Unknown status NCT00885664 Phase 4
3 HIV Persistence and Viral Reservoirs Unknown status NCT01025427 Phase 4
4 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4
5 Selenium Supplementation in Pregnancy Unknown status NCT01465867 Phase 4
6 Impact of Raltegravir on the Viral Reservoirs Unknown status NCT01249560 Phase 4
7 Efficacy of PTX+IFN Alpha+ RBV on Hepatitis C Virus Coinfected HIV Patients Unknown status NCT02008214 Phase 4
8 A Post Marketing Survey Study to Evaluate the Safety and Effectiveness of Intelence Completed NCT01741844 Phase 4
9 A Post Marketing Survey Study to Evaluate the Safety and Effectiveness of Prezista Completed NCT01741831 Phase 4
10 Immunologic Action of a Single Dose Cholecalciferol Completed NCT01845142 Phase 4
11 Immune and Metabolic Effects of Vitamin D Supplementation in Healthy Humans Completed NCT01248442 Phase 4
12 An Immunologic Study of Treatment-Naive HIV Patients Starting a Darunavir/Ritonavir- or Efavirenz-Based HAART Completed NCT01541085 Phase 4
13 Mechanisms of Immune Reconstitution & Reduced Immune Activation Following Darunavir-based ART Completed NCT01869634 Phase 4
14 Mesalamine to Reduce T Cell Activation in HIV Infection Completed NCT01090102 Phase 4
15 Valganciclovir to Reduce T Cell Activation in HIV Infection Completed NCT00264290 Phase 4
16 CCR5 Inhibitor Treatment Intensification on CD4+ T-cell Recovery Completed NCT00925756 Phase 4
17 Induction and Expansion of T Cell Repertoire Using Growth Hormone and Vaccination in HIV-1 Infected Patients Completed NCT00287677 Phase 4
18 Antiretroviral Therapy Intensification With Raltegravir or Addition of Hyper-immune Bovine Colostrum in HIV-1 Infected Patients With Suboptimal CD4+ T Cell Response Completed NCT00772590 Phase 4
19 Raltegravir Intensification in HIV-infected Patients Completed NCT00631449 Phase 4
20 Once-daily Antiretroviral Therapy in HIV-1 Infected Patients With CD4+ Cell Counts Below 100 Cells/Mcl Completed NCT00532168 Phase 4
21 Maraviroc as an Immunomodulatory Drug for Antiretroviral-treated HIV Infected Patients Exhibiting Immunologic Failure Completed NCT00735072 Phase 4
22 Vitamin D Supplementation in Patients With Diabetes Mellitus Type 2 Completed NCT01741181 Phase 4
23 A Pilot Project of Virologic, Pharmacologic and Immunologic Correlates of Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution Following Maraviroc Therapy Completed NCT00870363 Phase 4
24 Immunogenicity and Safety of Trivalent Influenza Vaccine in Non-pregnant HIV-infected Women Completed NCT01812980 Phase 4
25 A Research Study to See if a Change in Therapy for HIV Infection Can Improve the Immune Response to Treatment Completed NCT00145795 Phase 4
26 Study Of Investigational Regimen Combining FDA Approved HIV Drugs In HIV Subjects Experiencing Early Virologic Failure Completed NCT00038506 Phase 4
27 Yoga for the Management of HIV-Metabolic Syndromes Completed NCT00627380 Phase 4
28 Switching Undetectables to Selzentry Completed NCT01866267 Phase 4
29 Maraviroc in Immunological Non-Responder (INR) HIV-1-infected Subjects Completed NCT00884858 Phase 4
30 Intermittent Versus Continuous Medication in the Treatment of HIV Completed NCT00001967 Phase 4
31 Influence of the MDR1 Genotype on Blood Levels of Indinavir and Saquinavir in Healthy Volunteers Completed NCT00050180 Phase 4
32 Vaccine Responses to Influenza A H1N1/09 Immunization in High-risk Patients Completed NCT01022905 Phase 4
33 Strategies of Interruption/Reinitiation of Antiretroviral Therapy in HIV-Infected Patients With Lipodystrophy Completed NCT00646984 Phase 4
34 VENICE Study Nevirapine Full Dose/Dose Escalation Completed NCT00704249 Phase 4
35 4-Day-A-Week Treatment Plan for HIV Infected Adolescents Completed NCT00068809 Phase 4
36 Buprenorphine and Integrated HIV Care Completed NCT00317460 Phase 4
37 REMEMBER: Reducing Early Mortality & Morbidity by Empiric Tuberculosis (TB) Treatment Completed NCT01380080 Phase 4
38 Anti-Retrovirals for Kaposi's Sarcoma Completed NCT00444379 Phase 4
39 FOTO: Five Consecutive Days on Treatment With Efavirenz, Tenofovir, and Emtricitabine Followed by Two Days Off Treatment Versus Continuous Treatment Completed NCT00414635 Phase 4
40 Omega-3 Fatty Acids for High Triglycerides in HIV-infected Patients Completed NCT00346697 Phase 4
41 Antiretroviral Therapy for Advanced HIV Disease in South Africa Completed NCT00342355 Phase 4
42 A Study to Evaluate of the Efficacy of Enfuvirtide During the Induction Phase of Therapy Completed NCT00344760 Phase 4
43 Evaluation of 2 Interferon γ Assays in the Diagnosis of Latent Tuberculosis in HIV-infected Patients.ANRS EP 40 QUANTI SPOT Completed NCT00647205 Phase 4
44 DART II - A Phase IV Study of 3 Antiretroviral Medicines in Combination, in HIV Patients Who Have Not Been Previously Treated With Antiretroviral Therapy Completed NCT00116116 Phase 4
45 HIV Infection And Metabolic Abnormalities Protocol 1 (HAMA001) Completed NCT00192660 Phase 4
46 KIVEXA Vs TRUVADA, Both Administered With Efavirenz, In ART-Naive Subjects Completed NCT00549198 Phase 4
47 Study to Evaluate Darunavir/Ritonavir + Lamivudine Versus Continuing With Darunavir/Ritonavir + Tenofovir/Emtricitabine or Abacavir/Lamivudine in HIV Infected Subject Completed NCT02159599 Phase 4
48 TOTEM: Switch From Other Nucleoside Reverse Transcriptase Inhibitors (NRTIs) to Once Daily Truvada Completed NCT00323492 Phase 4
49 Immune Recovery in Advanced , ARV-naïve, HIV-1-infected Individuals Taking Dolutegravir or Ritonavir-boosted Darunavir Recruiting NCT02337322 Phase 4
50 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4

Search NIH Clinical Center for T Cell Deficiency

Genetic Tests for T Cell Deficiency

Anatomical Context for T Cell Deficiency

MalaCards organs/tissues related to T Cell Deficiency:

39
T Cells, B Cells, Bone, Bone Marrow, Neutrophil, Liver, Thymus

Publications for T Cell Deficiency

Articles related to T Cell Deficiency:

(show top 50) (show all 120)
id Title Authors Year
1
Roles of Aluminum Hydroxide and Monophosphoryl Lipid A Adjuvants in Overcoming CD4+ T Cell Deficiency To Induce Isotype-Switched IgG Antibody Responses and Protection by T-Dependent Influenza Vaccine. ( 27881702 )
2017
2
Syndrome of selective IgM deficiency with severe T cell deficiency associated with disseminated cutaneous mycobacterium avium intracellulaire infection. ( 26550546 )
2015
3
Mucosal-Associated Invariant T Cell Deficiency in Chronic Obstructive Pulmonary Disease. ( 26552490 )
2015
4
T cell deficiency in spinal cord injury: altered locomotor recovery and whole-genome transcriptional analysis. ( 26546062 )
2015
5
Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like disorder caused by loss-of-function mutations in LRBA. ( 25468195 )
2015
6
Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity. ( 26414901 )
2015
7
Invariant natural killer T cell deficiency leads to the development of spontaneous liver inflammation dependent on I^I'T cells in mice. ( 25791517 )
2015
8
Hypomorphic interleukin-7 receptor I+-chain mutations and T-cell deficiency: a delay in diagnosis. ( 26123418 )
2015
9
Blood dendritic cell levels associated with impaired IL-12 production and T-cell deficiency in patients with kidney disease: implications for post-transplant viral infections. ( 24963818 )
2014
10
Mucosal-associated invariant T cell deficiency in systemic lupus erythematosus. ( 25225673 )
2014
11
Interleukin-7 signalling defects in naive CD4+ T cells of HIV patients with CD4+ T-cell deficiency on antiretroviral therapy are associated with T-cell activation and senescence. ( 24499954 )
2014
12
Attenuated adipose tissue and skeletal muscle inflammation in obese mice with combined CD4+ and CD8+ T cell deficiency. ( 24530773 )
2014
13
Additional B-cell deficiency does not affect growth and angiogenesis of ectopic human endometrium in T-cell-deficient endometriosis mouse models during long-term culture. ( 25270508 )
2014
14
Regulatory T-cell deficiency in rheumatic heart disease: a preliminary observational study. ( 23610999 )
2013
15
Impaired spatial memory in mice lacking CD3IP is associated with altered NMDA and AMPA receptors signaling independent of T-cell deficiency. ( 24259588 )
2013
16
The protective effects of T cell deficiency against brain injury are ischemic model-dependent in rats. ( 23228347 )
2013
17
Fine-tuning of regulatory T cell function: the role of calcium signals and naive regulatory T cells for regulatory T cell deficiency in multiple sclerosis. ( 23576680 )
2013
18
Combined B- and T-cell deficiency does not protect against obesity-induced glucose intolerance and inflammation. ( 23478176 )
2013
19
VI'2 T cell deficiency in granulomatosis with polyangiitis (Wegener's granulomatosis). ( 23891739 )
2013
20
Ruling out HIV infection when testing for severe combined immunodeficiency and other T-cell deficiencies. ( 22386446 )
2012
21
CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis. ( 22312480 )
2012
22
Natural killer T cell deficiency in active adult-onset Still's Disease: correlation of deficiency of natural killer T cells with dysfunction of natural killer cells. ( 22605480 )
2012
23
CD8 T cell deficiency impairs control of Epstein--Barr virus and worsens with age in multiple sclerosis. ( 21791511 )
2012
24
Enzyme replacement therapy partially prevents invariant Natural Killer T cell deficiency in the Fabry disease mouse model. ( 22425450 )
2012
25
CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells. ( 22006994 )
2011
26
T cell deficiency does not reduce lesions in mice produced by intracerebral injection of NMO-IgG and complement. ( 21492943 )
2011
27
IL-15 ex vivo overcomes CD4+ T cell deficiency for the induction of human antigen-specific CD8+ T cell responses. ( 21474552 )
2011
28
Newborn screening for T-cell deficiency. ( 20864885 )
2010
29
Can T-cell deficiency affect spatial learning ability following toluene exposure? ( 19923859 )
2010
30
Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation. ( 20505149 )
2010
31
Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses. ( 20548030 )
2010
32
Profound invariant natural killer T-cell deficiency in inflammatory arthritis. ( 20444757 )
2010
33
Hematopoietic stem cell transplantation for profound T-cell deficiency (combined immunodeficiency). ( 20493397 )
2010
34
A multiplex immunoassay using the Guthrie specimen to detect T-cell deficiencies including severe combined immunodeficiency disease. ( 20660143 )
2010
35
Functional T-cell deficiency in adolescents who experience serogroup C meningococcal disease despite receiving the meningococcal serogroup C conjugate vaccine. ( 20463106 )
2010
36
Lung metastasis fails in MMTV-PyMT oncomice lacking S100A4 due to a T-cell deficiency in primary tumors. ( 20103644 )
2010
37
Common variable immunodeficiency with regulatory T-cell deficiency treated with rapamycin. ( 19230472 )
2009
38
Congenital T cell deficiency in a patient with CHARGE syndrome. ( 19187738 )
2009
39
Invariant natural killer (iNK) T cell deficiency in patients with common variable immunodeficiency. ( 19664144 )
2009
40
Generating functional CD8+ T cell memory response under transient CD4+ T cell deficiency: implications for vaccination of immunocompromised individuals. ( 18506880 )
2008
41
Hepatitis and human bocavirus primary infection in a child with T-cell deficiency. ( 18842946 )
2008
42
The effects of T cell deficiency on the development of worms and granuloma formation in mice infected with Schistosoma japonicum. ( 18246371 )
2008
43
Reduced protection from simian immunodeficiency virus SIVmac251 infection afforded by memory CD8+ T cells induced by vaccination during CD4+ T-cell deficiency. ( 18667509 )
2008
44
Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: roles of IL-2 versus IL-15. ( 18465774 )
2008
45
Adult onset of T-cell deficiency with impaired CD2 expression complicated by Rhodococcus infection: a case report. ( 17378264 )
2007
46
Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency. ( 16672702 )
2006
47
T cell deficiency leads to liver carcinogenesis in azoxymethane-treated rats. ( 16380649 )
2006
48
NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis. ( 17082625 )
2006
49
Long-lasting CD3+ T-cell deficiency after cord blood stem cell transplantation in a human herpesvirus 6-infected child. ( 15815044 )
2005
50
Responses against complex antigens in various models of CD4 T-cell deficiency: surprises from an anti-CD4 antibody transgenic mouse. ( 15258307 )
2004

Variations for T Cell Deficiency

Expression for T Cell Deficiency

Search GEO for disease gene expression data for T Cell Deficiency.

Pathways for T Cell Deficiency

Pathways related to T Cell Deficiency according to GeneCards Suite gene sharing:

(show all 17)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.61 CD247 CD4 CD8A IL15
2
Show member pathways
12.17 CD247 CD4 CD8A PTPRC
3 11.87 CD4 CD8A PTPRC
4
Show member pathways
11.75 CD247 CD4 CD8A
5
Show member pathways
11.72 CD247 CD4 PTPRC
6 11.66 CD4 CD8A IL7R
7
Show member pathways
11.66 CD247 CD4 CD8A PTPRC
8 11.6 IL15 IL7R PTPRC
9 11.49 CD247 CD4 PTPRC
10 11.44 CD4 CD8A IL7R PTPRC
11 11.43 CD247 CD4 CD8A
12 11.42 CD4 CD8A IL15 IL7R PTPRC
13 11.27 CD4 IL7R PTPRC
14 11.03 CD4 IL15
15 11.02 CD4 CD8A IL7R PTPRC
16 10.99 CD247 CD4
17 10.92 CD4 CD8A IL15 IL7R PTPRC

GO Terms for T Cell Deficiency

Cellular components related to T Cell Deficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.46 CD4 CD8A IL15 PTPRC
2 external side of plasma membrane GO:0009897 9.26 CD4 CD8A IL7R PTPRC
3 T cell receptor complex GO:0042101 8.8 CD247 CD4 CD8A

Biological processes related to T Cell Deficiency according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.8 CD4 CD8A IL15 IL7R
2 T cell receptor signaling pathway GO:0050852 9.63 CD247 CD4 PTPRC
3 B cell proliferation GO:0042100 9.51 IL7R PTPRC
4 positive regulation of T cell proliferation GO:0042102 9.5 CD4 IL15 PTPRC
5 regulation of defense response to virus by virus GO:0050690 9.48 CD247 CD4
6 positive regulation of calcium-mediated signaling GO:0050850 9.43 CD4 CD8A
7 pharyngeal system development GO:0060037 9.4 NKX2-6 TBX1
8 lymph node development GO:0048535 9.37 IL15 IL7R
9 negative regulation of T cell mediated cytotoxicity GO:0001915 9.26 IL7R PTPRC
10 interleukin-15-mediated signaling pathway GO:0035723 9.16 CD4 IL15
11 T cell differentiation GO:0030217 9.13 CD4 IL7R PTPRC
12 cell surface receptor signaling pathway GO:0007166 9.02 CD247 CD4 CD8A IL7R PTPRC

Molecular functions related to T Cell Deficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 8.96 CD4 CD8A
2 protein tyrosine kinase binding GO:1990782 8.62 CD247 CD4

Sources for T Cell Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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