MCID: TCL012
MIFTS: 39

T-Cell/histiocyte Rich Large B Cell Lymphoma

Categories: Rare diseases, Immune diseases, Blood diseases

Aliases & Classifications for T-Cell/histiocyte Rich Large B Cell Lymphoma

MalaCards integrated aliases for T-Cell/histiocyte Rich Large B Cell Lymphoma:

Name: T-Cell/histiocyte Rich Large B Cell Lymphoma 49 55
T-Cell/histiocyte Rich Large B-Cell Lymphoma 69
Thrlbcl 55

Characteristics:

Orphanet epidemiological data:

55
t-cell/histiocyte rich large b cell lymphoma
Inheritance: Multigenic/multifactorial,Not applicable;

Classifications:



External Ids:

Orphanet 55 ORPHA300857
UMLS via Orphanet 70 C1321547
ICD10 via Orphanet 33 C83.3
UMLS 69 C1321547

Summaries for T-Cell/histiocyte Rich Large B Cell Lymphoma

NIH Rare Diseases : 49 This condition doesn't have a summary yet. Please see our page(s) on Diffuse Large B-Cell Lymphoma.

MalaCards based summary : T-Cell/histiocyte Rich Large B Cell Lymphoma, also known as t-cell/histiocyte rich large b-cell lymphoma, is related to b-cell lymphomas and lymphoma, hodgkin, classic. An important gene associated with T-Cell/histiocyte Rich Large B Cell Lymphoma is BCL6 (B Cell CLL/Lymphoma 6), and among its related pathways/superpathways are B cell receptor signaling pathway (KEGG) and Complement and coagulation cascades. The drugs nivolumab and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for T-Cell/histiocyte Rich Large B Cell Lymphoma

Diseases related to T-Cell/histiocyte Rich Large B Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 b-cell lymphomas 31.4 BCL6 MME TNFRSF8
2 lymphoma, hodgkin, classic 30.7 BCL6 CD68 TNFRSF8
3 hemophagocytic lymphohistiocytosis 30.5 CR1 CR2 IFNG
4 diffuse large b-cell lymphoma 30.4 BCL6 MME TNFRSF8
5 lymphoma 11.0
6 nodular lymphocyte predominant hodgkin lymphoma 10.6
7 gallbladder lymphoma 10.5 BCL6 MME
8 heart lymphoma 10.5 BCL6 MME
9 intravascular large b-cell lymphoma 10.4 BCL6 MME
10 testicular lymphoma 10.4 BCL6 MME
11 angioimmunoblastic t-cell lymphoma 10.4 BCL6 MME
12 central nervous system leukemia 10.3 CR1 MME
13 ovarian lymphoma 10.3 CR2 MME
14 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.3
15 balloon cell malignant melanoma 10.3 CD68 MME
16 bladder lymphoma 10.3 CR2 MME
17 parapharyngeal meningioma 10.3 CR1 CR2
18 marginal zone b-cell lymphoma 10.2 BCL6 MME
19 interdigitating dendritic cell sarcoma 10.2 CR1 CR2
20 mature b-cell neoplasm 10.2 BCL6 MME
21 histiocytic and dendritic cell cancer 10.2 CR1 CR2
22 castleman disease 10.2 CR1 CR2
23 meningeal melanocytoma 10.2 CD68 MME
24 malignant leydig cell tumor 10.2 MME TNFRSF8
25 proliferative glomerulonephritis 10.2 CR1 IFNG
26 spleen cancer 10.1 CD68 CR2
27 colon lymphoma 10.1 BCL6 TNFRSF8
28 lateral medullary syndrome 10.1 CR1 CR2
29 epidural neoplasm 10.1 BCL6 TNFRSF8
30 pure red-cell aplasia 10.1
31 central nervous system lymphoma 10.1
32 duodenal obstruction 10.1
33 lymphopenia 10.1
34 thyroiditis 10.1
35 systemic lupus erythematosus 10.1
36 duodenitis 10.1
37 anemia, autoimmune hemolytic 10.1
38 lupus erythematosus 10.1
39 primary central nervous system lymphoma 10.1
40 chops syndrome 10.1
41 hemolytic anemia 10.1
42 lymphomatoid granulomatosis 10.1
43 lymphatic system cancer 10.1 BCL6 TNFRSF8
44 follicular lymphoma 1 10.1 BCL6 IGH
45 mediastinal malignant lymphoma 10.1 BCL6 TNFRSF8
46 follicular dendritic cell sarcoma 10.1 CR1 CR2
47 sternum cancer 10.0 CD68 TNFRSF8
48 langerhans cell sarcoma 10.0 CR1 CR2 VSIG4
49 mediastinal gray zone lymphoma 10.0 BCL6 SLC22A2 TNFRSF8
50 hodgkin's lymphoma, lymphocytic depletion 10.0 CD68 TNFRSF8

Graphical network of the top 20 diseases related to T-Cell/histiocyte Rich Large B Cell Lymphoma:



Diseases related to T-Cell/histiocyte Rich Large B Cell Lymphoma

Symptoms & Phenotypes for T-Cell/histiocyte Rich Large B Cell Lymphoma

MGI Mouse Phenotypes related to T-Cell/histiocyte Rich Large B Cell Lymphoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 BCL6 CD68 CR2 IFNG POU2F2 TNFRSF8
2 immune system MP:0005387 9.23 BCL6 CD68 CR2 IFNG MME POU2F2

Drugs & Therapeutics for T-Cell/histiocyte Rich Large B Cell Lymphoma

Drugs for T-Cell/histiocyte Rich Large B Cell Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Antibodies, Monoclonal Phase 2
3 Immunoglobulins Phase 2
4 Antibodies Phase 2
5
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
6
Fludarabine Approved Phase 1 21679-14-1, 75607-67-9 30751
7
Vidarabine Approved, Investigational Phase 1 24356-66-9 21704 32326
8 Alkylating Agents Phase 1
9 Vidarabine Phosphate Phase 1
10 Anti-Infective Agents Phase 1
11 Immunosuppressive Agents Phase 1
12 Antimetabolites Phase 1
13 Antimetabolites, Antineoplastic Phase 1
14 Antirheumatic Agents Phase 1
15 Antiviral Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab With or Without Varlilumab in Treating Patients With Relapsed or Refractory Aggressive B-cell Lymphomas Recruiting NCT03038672 Phase 2 Varlilumab
2 CD19/CD22 Chimeric Antigen Receptor T Cells and Chemotherapy in Treating Patients With Recurrent or Refractory CD19 Positive Diffuse Large B-Cell Lymphoma or B Acute Lymphoblastic Leukemia Recruiting NCT03233854 Phase 1 Cyclophosphamide;Fludarabine Phosphate
3 Study to Evaluate Safety and Tolerability of XmAb13676 in Patients With CD20-expressing Hematologic Malignancies Recruiting NCT02924402 Phase 1

Search NIH Clinical Center for T-Cell/histiocyte Rich Large B Cell Lymphoma

Genetic Tests for T-Cell/histiocyte Rich Large B Cell Lymphoma

Anatomical Context for T-Cell/histiocyte Rich Large B Cell Lymphoma

MalaCards organs/tissues related to T-Cell/histiocyte Rich Large B Cell Lymphoma:

38
B Cells, T Cells, Bone, Bone Marrow, Skin, Thymus, Spleen

Publications for T-Cell/histiocyte Rich Large B Cell Lymphoma

Articles related to T-Cell/histiocyte Rich Large B Cell Lymphoma:

(show all 46)
# Title Authors Year
1
Hemophagocytic Lymphohistiocytosis Secondary to T Cell/Histiocyte-rich Large B Cell Lymphoma in an Adolescent Male. ( 29187030 )
2018
2
T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Presented as T-Lymphoid Hyperplasia Involving the Central Nervous System. ( 28451478 )
2017
3
Predominance of CD4+ T Cells in T-Cell/Histiocyte-Rich Large B-Cell Lymphoma and Identification of a Subset of Patients With Peripheral B-Cell Lymphopenia. ( 28575178 )
2017
4
T Cell Histiocyte Rich Large B Cell Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis: An Uncommon Presentation of a Rare Disease. ( 28912991 )
2017
5
T-cell/histiocyte-rich large B-cell lymphoma of stomach. ( 27427148 )
2016
6
T Cell/Histiocyte-Rich Large B Cell Lymphoma of the Thymus: A Diagnostic Pitfall. ( 26904321 )
2016
7
T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Presenting as a Primary Central Nervous System Lymphoma. ( 26788280 )
2015
8
From a pathologist's point of view: Histiocytic cells in Hodgkin lymphoma and T cell/histiocyte rich large B cell lymphoma. ( 26596262 )
2015
9
T-cell/histiocyte-rich large B-cell lymphoma in pediatric patients: an under-recognized entity? ( 25696014 )
2015
10
A T-cell/histiocyte-rich large B-cell lymphoma involving only the bone marrow. ( 26770945 )
2015
11
Array comparative genomic hybridization reveals similarities between nodular lymphocyte predominant Hodgkin lymphoma and T cell/histiocyte rich large B cell lymphoma. ( 25644177 )
2015
12
Reactive T cells by flow cytometry distinguish Hodgkin lymphomas from T cell/histiocyte-rich large B cell lymphoma. ( 26084540 )
2015
13
T-cell/histiocyte-rich large B-cell lymphoma--transformation of nodular lymphocyte predominant Hodgkin lymphoma in the bone marrow. ( 24483596 )
2014
14
Hemophagocytic lymphohistiocytosis secondary to T-cell/histiocyte-rich large B-cell lymphoma. ( 24955327 )
2014
15
Diagnosis of primary pulmonary T- cell/histiocyte-rich large B cell lymphoma with tissue eosinophilia via clinicopathological observation and molecular assay. ( 25273521 )
2014
16
Anti-erythropoietin receptor antibody-associated pure red cell aplasia accompanied by Coombs-negative autoimmune hemolytic anemia in a patient with T cell/histiocyte-rich large B cell lymphoma. ( 25096221 )
2014
17
T-cell/histiocyte-rich large B-cell lymphoma with zonal expansion of fibroblastic reticulum cells and infiltration by a subpopulation of myeloperoxidase positive histiocytes. ( 25042387 )
2014
18
Upregulation of innate immune responses in a T cell/histiocyte-rich large B cell lymphoma patient with significant autoimmune disorders mimicking systemic lupus erythematosus. ( 23743539 )
2014
19
Fatal necrotizing angiotropic Epstein-Barr virus-negative large B-cell lymphoma: a case report with unusual clinicopathological features in-between lymphomatoid granulomatosis and T-cell/histiocyte-rich large B-cell lymphoma. ( 25546693 )
2014
20
Nodular Lymphocyte Predominant Hodgkin Lymphoma versus T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Diagnostic Challenge. ( 25110597 )
2014
21
Does functional imaging distinguish nodular lymphocyte-predominant hodgkin lymphoma from T-cell/histiocyte-rich large B-cell lymphoma? ( 23773450 )
2013
22
Macrophages in T cell/histiocyte rich large B cell lymphoma strongly express metal-binding proteins and show a bi-activated phenotype. ( 23686423 )
2013
23
First case of T-cell/histiocyte-rich-large B-cell lymphoma presenting with duodenal obstruction. ( 24345670 )
2013
24
T-cell/histiocyte-rich large B-cell lymphoma of the thyroid. ( 23298413 )
2013
25
Primary bone marrow T-cell/histiocyte-rich large B-cell lymphoma: a diagnostic challenge. ( 23562349 )
2013
26
Nodular lymphocyte predominant hodgkin lymphoma and T cell/histiocyte rich large B cell lymphoma - endpoints of a spectrum of one disease? ( 24244368 )
2013
27
Multiple cytokine- and chemokine-producing T-cell/histiocyte-rich large B-cell lymphoma. ( 23278285 )
2013
28
Matched-Pair Analysis Comparing the Outcomes of T Cell/Histiocyte-Rich Large B Cell Lymphoma and Diffuse Large B Cell Lymphoma in Patients Treated with Rituximab-CHOP. ( 24192382 )
2013
29
Extranodal T-cell/histiocyte-rich large B-cell lymphoma presenting primarily on the skin. ( 22948794 )
2012
30
Primary T cell/histiocyte-rich large B-cell lymphoma of the orbit. ( 20562665 )
2011
31
T cell/histiocyte-rich large B-cell lymphoma: an update on its biology and classification. ( 22081105 )
2011
32
T-cell/histiocyte-rich large B-cell lymphoma shows transcriptional features suggestive of a tolerogenic host immune response. ( 19797726 )
2010
33
T-cell/histiocyte-rich large B-cell lymphoma. ( 20207840 )
2010
34
Nodular lymphocyte-predominant Hodgkin lymphoma and T cell histiocyte-rich large B cell lymphoma: diagnosis in two monozygotic twins. ( 20653789 )
2010
35
Splenic micronodular T-cell/histiocyte-rich large B-cell lymphoma: effect of prior corticosteroid therapy. ( 19763612 )
2009
36
Morphologic, immunphenotypic and clinical discriminators between T-cell/histiocyte-rich large B-cell lymphoma and lymphocyte-predominant Hodgkin lymphoma. ( 20063524 )
2008
37
Nodular lymphocyte-predominant hodgkin lymphoma or T-cell/histiocyte rich large B-cell lymphoma: the problem in "grey zone" lymphomas. ( 18784812 )
2008
38
Splenic micronodular T-cell/histiocyte-rich large B-cell lymphoma. ( 18620998 )
2008
39
T-cell/histiocyte-rich large B-cell lymphoma associated with a near-tetraploid karyotype and complex genetic abnormalities. ( 16856972 )
2006
40
Pediatric EBV-positive T-cell/histiocyte-rich large B-cell lymphoma with clonal cells in the bone marrow without overt involvement. ( 15621841 )
2005
41
T-cell/histiocyte-rich large B-cell lymphoma displays a heterogeneity similar to diffuse large B-cell lymphoma: a clinicopathologic, immunohistochemical, and molecular study of 30 cases. ( 15894921 )
2005
42
Micronodular T-cell/histiocyte-rich large B-cell lymphoma of the spleen: histology, immunophenotype, and differential diagnosis. ( 12826882 )
2003
43
T-cell/histiocyte-rich large B-cell lymphoma: a heterogeneous entity with derivation from germinal center B cells. ( 12409722 )
2002
44
T-cell/histiocyte-rich large B-cell lymphoma: a distinct clinicopathologic entity. ( 11870169 )
2002
45
T-cell/histiocyte-rich large B-cell lymphoma is a disseminated aggressive neoplasm: differential diagnosis from Hodgkin's lymphoma. ( 12207783 )
2002
46
CD5+ T-cell/histiocyte-rich large B-cell lymphoma. ( 12379751 )
2002

Variations for T-Cell/histiocyte Rich Large B Cell Lymphoma

Expression for T-Cell/histiocyte Rich Large B Cell Lymphoma

Search GEO for disease gene expression data for T-Cell/histiocyte Rich Large B Cell Lymphoma.

Pathways for T-Cell/histiocyte Rich Large B Cell Lymphoma

GO Terms for T-Cell/histiocyte Rich Large B Cell Lymphoma

Biological processes related to T-Cell/histiocyte Rich Large B Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein import into nucleus, translocation GO:0000060 9.16 BCL6 IFNG
2 regulation of regulatory T cell differentiation GO:0045589 8.96 CR1 IFNG
3 complement receptor mediated signaling pathway GO:0002430 8.62 CR1 CR2

Sources for T-Cell/histiocyte Rich Large B Cell Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
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29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
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45 NCI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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