MCID: TCL012
MIFTS: 35

T-Cell/histiocyte Rich Large B Cell Lymphoma malady

Categories: Rare diseases, Blood diseases, Immune diseases

Aliases & Classifications for T-Cell/histiocyte Rich Large B Cell Lymphoma

Aliases & Descriptions for T-Cell/histiocyte Rich Large B Cell Lymphoma:

Name: T-Cell/histiocyte Rich Large B Cell Lymphoma 50 56
T-Cell/histiocyte Rich Large B-Cell Lymphoma 69
Thrlbcl 56

Characteristics:

Orphanet epidemiological data:

56
t-cell/histiocyte rich large b cell lymphoma
Inheritance: Multigenic/multifactorial,Not applicable;

Classifications:



External Ids:

Orphanet 56 ORPHA300857
UMLS via Orphanet 70 C1321547
ICD10 via Orphanet 34 C83.3

Summaries for T-Cell/histiocyte Rich Large B Cell Lymphoma

MalaCards based summary : T-Cell/histiocyte Rich Large B Cell Lymphoma, also known as t-cell/histiocyte rich large b-cell lymphoma, is related to b-cell lymphomas and lymphoma. An important gene associated with T-Cell/histiocyte Rich Large B Cell Lymphoma is SLC22A2 (Solute Carrier Family 22 Member 2), and among its related pathways/superpathways are B cell receptor signaling pathway (KEGG) and Complement and coagulation cascades. The drugs Doxorubicin and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for T-Cell/histiocyte Rich Large B Cell Lymphoma

Diseases related to T-Cell/histiocyte Rich Large B Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
id Related Disease Score Top Affiliating Genes
1 b-cell lymphomas 10.9
2 lymphoma 10.9
3 hodgkin lymphoma 10.6
4 nodular lymphocyte predominant hodgkin lymphoma 10.5
5 ethmoid sinus inverted papilloma 10.3 BCL6 MME
6 coloboma of eyelid 10.3 BCL6 MME
7 diffuse large b-cell lymphoma 10.2
8 cataract, total congenital 10.2 CR1 IFNG
9 skin amelanotic melanoma 10.2 CD68 MME
10 lower clivus meningioma 10.2 CR1 CR2
11 degenerative myopia 10.2 CR2 MME
12 ovarian wilms' cancer 10.2 CR2 MME
13 mite infestation 10.2 CR1 CR2
14 adenosquamous colon carcinoma 10.2 CR1 CR2
15 chronic wasting disease 10.1 CR1 CR2
16 bilateral breast cancer 10.1 CD68 CR2
17 penile disease 10.1 BCL6 TNFRSF8
18 paranasal sinus cancer 10.1 MME TNFRSF8
19 uterine corpus leiomyomatosis 10.1 CD68 MME
20 spinal cord intramedullary teratoma 10.1 BCL6 TNFRSF8
21 heavy chain disease 10.1 CD68 MME
22 immune-complex glomerulonephritis 10.1 CR1 IFNG
23 ureter transitional cell carcinoma 10.1 BCL6 TNFRSF8
24 microcystic adenoma 10.1 BCL6 MME
25 ichthyosis, congenital, autosomal recessive 10 10.1 BCL6 IGH
26 nutritional deficiency disease 10.1 CD68 TNFRSF8
27 autoimmune hemolytic anemia 10.1
28 duodenitis 10.1
29 lupus erythematosus 10.1
30 primary central nervous system lymphoma 10.1
31 systemic lupus erythematosus 10.1
32 hemolytic anemia 10.1
33 hemophagocytic lymphohistiocytosis 10.1
34 lymphomatoid granulomatosis 10.1
35 pure red-cell aplasia 10.1
36 central nervous system lymphoma 10.1
37 duodenal obstruction 10.1
38 thyroiditis 10.1
39 cloacogenic carcinoma 10.1 CR1 CR2 VSIG4
40 ureter small cell carcinoma 10.1 BCL6 SLC22A2 TNFRSF8
41 subacute delirium 10.1 CD68 TNFRSF8
42 ectodermal dysplasia 10.0 BCL6 MME TNFRSF8
43 periventricular leukomalacia 10.0 CD68 IFNG
44 mammary paget's disease 10.0 CD68 TNFRSF8
45 hereditary ataxia 10.0 CR1 CR2 IFNG
46 cerebral arterial disease 10.0 CD68 TNFRSF8
47 bladder disease 10.0 BCL6 MME TNFRSF8
48 herpetic whitlow 10.0 CD68 TNFRSF8
49 lip cancer 10.0 BCL6 TNFRSF8
50 pancreatic serous cystadenoma 10.0 CR2 TNFRSF8

Graphical network of the top 20 diseases related to T-Cell/histiocyte Rich Large B Cell Lymphoma:



Diseases related to T-Cell/histiocyte Rich Large B Cell Lymphoma

Symptoms & Phenotypes for T-Cell/histiocyte Rich Large B Cell Lymphoma

MGI Mouse Phenotypes related to T-Cell/histiocyte Rich Large B Cell Lymphoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 POU2F2 TNFRSF8 VSIG4 BCL6 CD68 CR2
2 immune system MP:0005387 9.23 POU2F2 TNFRSF8 VSIG4 BCL6 CD68 CR2

Drugs & Therapeutics for T-Cell/histiocyte Rich Large B Cell Lymphoma

Drugs for T-Cell/histiocyte Rich Large B Cell Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
2
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
3
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
4
rituximab Approved Phase 3 174722-31-7 10201696
5
Lenalidomide Approved Phase 3 191732-72-6 216326
6
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
7
Doxil Approved June 1999 Phase 3 31703
8 Alkylating Agents Phase 3
9 glucocorticoids Phase 3
10 Topoisomerase Inhibitors Phase 3
11 Hormone Antagonists Phase 3
12 Hormones Phase 3
13 Angiogenesis Inhibitors Phase 3
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
15 Angiogenesis Modulating Agents Phase 3
16 Anti-Bacterial Agents Phase 3
17 Anti-Infective Agents Phase 3
18 Immunosuppressive Agents Phase 3
19 Anti-Inflammatory Agents Phase 3
20 Antibiotics, Antitubercular Phase 3
21 Antimitotic Agents Phase 3
22 Antirheumatic Agents Phase 3
23 Antineoplastic Agents, Alkylating Phase 3
24 Antineoplastic Agents, Hormonal Phase 3
25 Antineoplastic Agents, Phytogenic Phase 3
26
nivolumab Approved Phase 2 946414-94-4
27 Immunoglobulin G Phase 2
28 Immunoglobulins Phase 2
29 Antibodies, Monoclonal Phase 2
30 Antibodies Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Efficacy and Safety Study of Lenalidomide Plus R-CHOP Chemotherapy Versus Placebo Plus R-CHOP Chemotherapy in Untreated ABC Type Diffuse Large B-cell Lymphoma Recruiting NCT02285062 Phase 3
2 Phase IIa Study of Redirected Autologous T Cells Engineered to Contain Anti-CD19 Attached to TCRz and 4-Signaling Domains in Patients With Chemotherapy Relapsed or Refractory CD19+ Lymphomas Recruiting NCT02030834 Phase 2
3 Nivolumab With or Without Varlilumab in Treating Patients With Relapsed or Refractory Aggressive B-cell Lymphomas Not yet recruiting NCT03038672 Phase 2
4 Study to Evaluate Safety and Tolerability of XmAb13676 in Patients With CD20-expressing Hematologic Malignancies Recruiting NCT02924402 Phase 1

Search NIH Clinical Center for T-Cell/histiocyte Rich Large B Cell Lymphoma

Genetic Tests for T-Cell/histiocyte Rich Large B Cell Lymphoma

Anatomical Context for T-Cell/histiocyte Rich Large B Cell Lymphoma

MalaCards organs/tissues related to T-Cell/histiocyte Rich Large B Cell Lymphoma:

39
B Cells, T Cells, Bone, Bone Marrow, Skin, Thymus, Spleen

Publications for T-Cell/histiocyte Rich Large B Cell Lymphoma

Articles related to T-Cell/histiocyte Rich Large B Cell Lymphoma:

(show all 42)
id Title Authors Year
1
T Cell/Histiocyte-Rich Large B Cell Lymphoma of the Thymus: A Diagnostic Pitfall. ( 26904321 )
2016
2
T-cell/histiocyte-rich large B-cell lymphoma of stomach. ( 27427148 )
2016
3
Reactive T cells by flow cytometry distinguish Hodgkin lymphomas from T cell/histiocyte-rich large B cell lymphoma. ( 26084540 )
2015
4
A T-cell/histiocyte-rich large B-cell lymphoma involving only the bone marrow. ( 26770945 )
2015
5
From a pathologist's point of view: Histiocytic cells in Hodgkin lymphoma and T cell/histiocyte rich large B cell lymphoma. ( 26596262 )
2015
6
T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Presenting as a Primary Central Nervous System Lymphoma. ( 26788280 )
2015
7
T-cell/histiocyte-rich large B-cell lymphoma in pediatric patients: an under-recognized entity? ( 25696014 )
2015
8
Array comparative genomic hybridization reveals similarities between nodular lymphocyte predominant Hodgkin lymphoma and T cell/histiocyte rich large B cell lymphoma. ( 25644177 )
2015
9
Fatal necrotizing angiotropic Epstein-Barr virus-negative large B-cell lymphoma: a case report with unusual clinicopathological features in-between lymphomatoid granulomatosis and T-cell/histiocyte-rich large B-cell lymphoma. ( 25546693 )
2014
10
Diagnosis of primary pulmonary T- cell/histiocyte-rich large B cell lymphoma with tissue eosinophilia via clinicopathological observation and molecular assay. ( 25273521 )
2014
11
Anti-erythropoietin receptor antibody-associated pure red cell aplasia accompanied by Coombs-negative autoimmune hemolytic anemia in a patient with T cell/histiocyte-rich large B cell lymphoma. ( 25096221 )
2014
12
Nodular Lymphocyte Predominant Hodgkin Lymphoma versus T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Diagnostic Challenge. ( 25110597 )
2014
13
T-cell/histiocyte-rich large B-cell lymphoma--transformation of nodular lymphocyte predominant Hodgkin lymphoma in the bone marrow. ( 24483596 )
2014
14
Upregulation of innate immune responses in a T cell/histiocyte-rich large B cell lymphoma patient with significant autoimmune disorders mimicking systemic lupus erythematosus. ( 23743539 )
2014
15
T-cell/histiocyte-rich large B-cell lymphoma with zonal expansion of fibroblastic reticulum cells and infiltration by a subpopulation of myeloperoxidase positive histiocytes. ( 25042387 )
2014
16
Hemophagocytic lymphohistiocytosis secondary to T-cell/histiocyte-rich large B-cell lymphoma. ( 24955327 )
2014
17
Nodular lymphocyte predominant hodgkin lymphoma and T cell/histiocyte rich large B cell lymphoma - endpoints of a spectrum of one disease? ( 24244368 )
2013
18
Does functional imaging distinguish nodular lymphocyte-predominant hodgkin lymphoma from T-cell/histiocyte-rich large B-cell lymphoma? ( 23773450 )
2013
19
T-cell/histiocyte-rich large B-cell lymphoma of the thyroid. ( 23298413 )
2013
20
Macrophages in T cell/histiocyte rich large B cell lymphoma strongly express metal-binding proteins and show a bi-activated phenotype. ( 23686423 )
2013
21
Multiple cytokine- and chemokine-producing T-cell/histiocyte-rich large B-cell lymphoma. ( 23278285 )
2013
22
Matched-Pair Analysis Comparing the Outcomes of T Cell/Histiocyte-Rich Large B Cell Lymphoma and Diffuse Large B Cell Lymphoma in Patients Treated with Rituximab-CHOP. ( 24192382 )
2013
23
First case of T-cell/histiocyte-rich-large B-cell lymphoma presenting with duodenal obstruction. ( 24345670 )
2013
24
Primary bone marrow T-cell/histiocyte-rich large B-cell lymphoma: a diagnostic challenge. ( 23562349 )
2013
25
Extranodal T-cell/histiocyte-rich large B-cell lymphoma presenting primarily on the skin. ( 22948794 )
2012
26
T cell/histiocyte-rich large B-cell lymphoma: an update on its biology and classification. ( 22081105 )
2011
27
Primary T cell/histiocyte-rich large B-cell lymphoma of the orbit. ( 20562665 )
2011
28
T-cell/histiocyte-rich large B-cell lymphoma. ( 20207840 )
2010
29
T-cell/histiocyte-rich large B-cell lymphoma shows transcriptional features suggestive of a tolerogenic host immune response. ( 19797726 )
2010
30
Nodular lymphocyte-predominant Hodgkin lymphoma and T cell histiocyte-rich large B cell lymphoma: diagnosis in two monozygotic twins. ( 20653789 )
2010
31
Splenic micronodular T-cell/histiocyte-rich large B-cell lymphoma: effect of prior corticosteroid therapy. ( 19763612 )
2009
32
Nodular lymphocyte-predominant hodgkin lymphoma or T-cell/histiocyte rich large B-cell lymphoma: the problem in "grey zone" lymphomas. ( 18784812 )
2008
33
Splenic micronodular T-cell/histiocyte-rich large B-cell lymphoma. ( 18620998 )
2008
34
Morphologic, immunphenotypic and clinical discriminators between T-cell/histiocyte-rich large B-cell lymphoma and lymphocyte-predominant Hodgkin lymphoma. ( 20063524 )
2008
35
T-cell/histiocyte-rich large B-cell lymphoma associated with a near-tetraploid karyotype and complex genetic abnormalities. ( 16856972 )
2006
36
T-cell/histiocyte-rich large B-cell lymphoma displays a heterogeneity similar to diffuse large B-cell lymphoma: a clinicopathologic, immunohistochemical, and molecular study of 30 cases. ( 15894921 )
2005
37
Pediatric EBV-positive T-cell/histiocyte-rich large B-cell lymphoma with clonal cells in the bone marrow without overt involvement. ( 15621841 )
2005
38
Micronodular T-cell/histiocyte-rich large B-cell lymphoma of the spleen: histology, immunophenotype, and differential diagnosis. ( 12826882 )
2003
39
CD5+ T-cell/histiocyte-rich large B-cell lymphoma. ( 12379751 )
2002
40
T-cell/histiocyte-rich large B-cell lymphoma: a distinct clinicopathologic entity. ( 11870169 )
2002
41
T-cell/histiocyte-rich large B-cell lymphoma: a heterogeneous entity with derivation from germinal center B cells. ( 12409722 )
2002
42
T-cell/histiocyte-rich large B-cell lymphoma is a disseminated aggressive neoplasm: differential diagnosis from Hodgkin's lymphoma. ( 12207783 )
2002

Variations for T-Cell/histiocyte Rich Large B Cell Lymphoma

Expression for T-Cell/histiocyte Rich Large B Cell Lymphoma

Search GEO for disease gene expression data for T-Cell/histiocyte Rich Large B Cell Lymphoma.

Pathways for T-Cell/histiocyte Rich Large B Cell Lymphoma

GO Terms for T-Cell/histiocyte Rich Large B Cell Lymphoma

Biological processes related to T-Cell/histiocyte Rich Large B Cell Lymphoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein import into nucleus, translocation GO:0000060 8.96 BCL6 IFNG
2 complement receptor mediated signaling pathway GO:0002430 8.62 CR1 CR2

Sources for T-Cell/histiocyte Rich Large B Cell Lymphoma

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7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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31 HMDB
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33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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