MCID: TCL012
MIFTS: 36

T-Cell/histiocyte Rich Large B Cell Lymphoma

Categories: Rare diseases, Blood diseases, Immune diseases

Aliases & Classifications for T-Cell/histiocyte Rich Large B Cell Lymphoma

MalaCards integrated aliases for T-Cell/histiocyte Rich Large B Cell Lymphoma:

Name: T-Cell/histiocyte Rich Large B Cell Lymphoma 50 56
T-Cell/histiocyte Rich Large B-Cell Lymphoma 69
Thrlbcl 56

Characteristics:

Orphanet epidemiological data:

56
t-cell/histiocyte rich large b cell lymphoma
Inheritance: Multigenic/multifactorial,Not applicable;

Classifications:



External Ids:

Orphanet 56 ORPHA300857
UMLS via Orphanet 70 C1321547
ICD10 via Orphanet 34 C83.3

Summaries for T-Cell/histiocyte Rich Large B Cell Lymphoma

NIH Rare Diseases : 50 this condition doesn't have a summary yet. please see our page(s) on diffuse large b-cell lymphoma.

MalaCards based summary : T-Cell/histiocyte Rich Large B Cell Lymphoma, also known as t-cell/histiocyte rich large b-cell lymphoma, is related to b-cell lymphomas and lymphoma. An important gene associated with T-Cell/histiocyte Rich Large B Cell Lymphoma is BCL6 (B-Cell CLL/Lymphoma 6), and among its related pathways/superpathways are B cell receptor signaling pathway (KEGG) and Complement and coagulation cascades. The drugs Cyclophosphamide and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for T-Cell/histiocyte Rich Large B Cell Lymphoma

Diseases related to T-Cell/histiocyte Rich Large B Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
id Related Disease Score Top Affiliating Genes
1 b-cell lymphomas 10.9
2 lymphoma 10.9
3 gastric small cell carcinoma 10.7 BCL6 MME
4 blake pouch cyst 10.7 BCL6 MME
5 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.6 BCL6 MME
6 hodgkin lymphoma 10.6
7 nodular lymphocyte predominant hodgkin lymphoma 10.5
8 ovarian wilms' cancer 10.5 CR2 MME
9 degenerative myopia 10.4 CR2 MME
10 endometrial disease 10.4 CD68 MME
11 central breast papilloma 10.4 CR1 CR2
12 adult central nervous system germinoma 10.4 CR1 CR2
13 melanoma metastasis 10.4 BCL6 MME
14 esophageal adenosquamous carcinoma 10.4 CR1 CR2
15 cataract congenital autosomal dominant 10.3 CR1 CR2
16 malignant melanocytic peripheral nerve sheath tumor of mediastinum 10.3 BCL6 MME
17 phobic disorder 10.3 CD68 MME
18 connective tissue benign neoplasm 10.3 CD68 MME
19 malignant sertoli-leydig cell tumor 10.3 MME TNFRSF8
20 diffuse glomerulonephritis 10.3 CR1 IFNG
21 penile disease 10.3 BCL6 TNFRSF8
22 fibrillary astrocytoma 10.3 CD68 CR2
23 childhood spinal cord tumor 10.3 BCL6 TNFRSF8
24 anterior cerebral artery infarction 10.3 CR1 CR2
25 lymphoma, large-cell, immunoblastic 10.3 BCL6 MME
26 diffuse large b-cell lymphoma 10.2
27 hemophagocytic lymphohistiocytosis 10.2
28 spinal cord neuroblastoma 10.2 BCL6 TNFRSF8
29 periventricular leukomalacia 10.2 CD68 IFNG
30 thrombocytopenia, anemia, and myelofibrosis 10.2 BCL6 IGH
31 gastric cardia adenocarcinoma 10.1 CR1 CR2
32 inner ear cancer 10.1 CD68 TNFRSF8
33 chronic intestinal vascular insufficiency 10.1 CD68 TNFRSF8
34 endometrioid ovary carcinoma 10.1 MME TNFRSF8
35 rectum leiomyoma 10.1 CR1 CR2 VSIG4
36 hepatoblastoma 10.1 BCL6 SLC22A2 TNFRSF8
37 pancreatic cystadenoma 10.1 CR2 TNFRSF8
38 systemic lupus erythematosus 10.1
39 hemolytic anemia 10.1
40 lymphomatoid granulomatosis 10.1
41 pure red-cell aplasia 10.1
42 central nervous system lymphoma 10.1
43 duodenal obstruction 10.1
44 lymphopenia 10.1
45 thyroiditis 10.1
46 autoimmune hemolytic anemia 10.1
47 duodenitis 10.1
48 lupus erythematosus 10.1
49 primary central nervous system lymphoma 10.1
50 laryngitis 10.1 CD68 TNFRSF8

Graphical network of the top 20 diseases related to T-Cell/histiocyte Rich Large B Cell Lymphoma:



Diseases related to T-Cell/histiocyte Rich Large B Cell Lymphoma

Symptoms & Phenotypes for T-Cell/histiocyte Rich Large B Cell Lymphoma

MGI Mouse Phenotypes related to T-Cell/histiocyte Rich Large B Cell Lymphoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 CR2 IFNG POU2F2 TNFRSF8 VSIG4 BCL6
2 immune system MP:0005387 9.23 CR2 IFNG MME POU2F2 TNFRSF8 VSIG4

Drugs & Therapeutics for T-Cell/histiocyte Rich Large B Cell Lymphoma

Drugs for T-Cell/histiocyte Rich Large B Cell Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 3,Phase 1 50-18-0, 6055-19-2 2907
2
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
3
Lenalidomide Approved Phase 3 191732-72-6 216326
4
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
5
rituximab Approved Phase 3 174722-31-7 10201696
6
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
7
Doxil Approved June 1999 Phase 3 31703
8 Alkylating Agents Phase 3,Phase 1
9 Anti-Infective Agents Phase 3,Phase 1
10 Antirheumatic Agents Phase 3,Phase 1
11 Immunosuppressive Agents Phase 3,Phase 1
12 Angiogenesis Inhibitors Phase 3
13 Angiogenesis Modulating Agents Phase 3
14 Anti-Bacterial Agents Phase 3
15 Antibiotics, Antitubercular Phase 3
16 Anti-Inflammatory Agents Phase 3
17 Antimitotic Agents Phase 3
18 Antineoplastic Agents, Hormonal Phase 3
19 Antineoplastic Agents, Phytogenic Phase 3
20 glucocorticoids Phase 3
21 Hormone Antagonists Phase 3
22 Hormones Phase 3
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
24 Topoisomerase Inhibitors Phase 3
25
nivolumab Approved Phase 2 946414-94-4
26 Antibodies Phase 2
27 Antibodies, Monoclonal Phase 2
28 Immunoglobulins Phase 2
29
Fludarabine Approved Phase 1 21679-14-1, 75607-67-9 30751
30
Vidarabine Approved Phase 1 24356-66-9 32326 21704
31 Antimetabolites Phase 1
32 Antimetabolites, Antineoplastic Phase 1
33 Antiviral Agents Phase 1
34 Vidarabine Phosphate Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Lenalidomide Plus R-CHOP Chemotherapy Versus Placebo Plus R-CHOP Chemotherapy in Untreated ABC Type Diffuse Large B-cell Lymphoma Active, not recruiting NCT02285062 Phase 3 lenalidomide;Placebo;Rituximab;Cyclophosphamide;Doxorubicin;prednisone;vincristine
2 Phase IIa Study of Redirected Autologous T Cells Engineered to Contain Anti-CD19 Attached to TCRz and 4-Signaling Domains in Patients With Chemotherapy Relapsed or Refractory CD19+ Lymphomas Recruiting NCT02030834 Phase 2
3 Nivolumab With or Without Varlilumab in Treating Patients With Relapsed or Refractory Aggressive B-cell Lymphomas Not yet recruiting NCT03038672 Phase 2 Varlilumab
4 CD19/CD22 Chimeric Antigen Receptor T Cells and Chemotherapy in Treating Patients With Recurrent or Refractory CD19 Positive Diffuse Large B-Cell Lymphoma or B Acute Lymphoblastic Leukemia Recruiting NCT03233854 Phase 1 Cyclophosphamide;Fludarabine Phosphate
5 Study to Evaluate Safety and Tolerability of XmAb13676 in Patients With CD20-expressing Hematologic Malignancies Recruiting NCT02924402 Phase 1

Search NIH Clinical Center for T-Cell/histiocyte Rich Large B Cell Lymphoma

Genetic Tests for T-Cell/histiocyte Rich Large B Cell Lymphoma

Anatomical Context for T-Cell/histiocyte Rich Large B Cell Lymphoma

MalaCards organs/tissues related to T-Cell/histiocyte Rich Large B Cell Lymphoma:

39
B Cells, T Cells, Bone, Bone Marrow, Skin, Thymus, Spleen

Publications for T-Cell/histiocyte Rich Large B Cell Lymphoma

Articles related to T-Cell/histiocyte Rich Large B Cell Lymphoma:

(show all 45)
id Title Authors Year
1
Predominance of CD4+ T Cells in T-Cell/Histiocyte-Rich Large B-Cell Lymphoma and Identification of a Subset of Patients With Peripheral B-Cell Lymphopenia. ( 28575178 )
2017
2
T Cell Histiocyte Rich Large B Cell Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis: An Uncommon Presentation of a Rare Disease. ( 28912991 )
2017
3
T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Presented as T-Lymphoid Hyperplasia Involving the Central Nervous System. ( 28451478 )
2017
4
T-cell/histiocyte-rich large B-cell lymphoma of stomach. ( 27427148 )
2016
5
T Cell/Histiocyte-Rich Large B Cell Lymphoma of the Thymus: A Diagnostic Pitfall. ( 26904321 )
2016
6
From a pathologist's point of view: Histiocytic cells in Hodgkin lymphoma and T cell/histiocyte rich large B cell lymphoma. ( 26596262 )
2015
7
T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Presenting as a Primary Central Nervous System Lymphoma. ( 26788280 )
2015
8
T-cell/histiocyte-rich large B-cell lymphoma in pediatric patients: an under-recognized entity? ( 25696014 )
2015
9
A T-cell/histiocyte-rich large B-cell lymphoma involving only the bone marrow. ( 26770945 )
2015
10
Array comparative genomic hybridization reveals similarities between nodular lymphocyte predominant Hodgkin lymphoma and T cell/histiocyte rich large B cell lymphoma. ( 25644177 )
2015
11
Reactive T cells by flow cytometry distinguish Hodgkin lymphomas from T cell/histiocyte-rich large B cell lymphoma. ( 26084540 )
2015
12
Nodular Lymphocyte Predominant Hodgkin Lymphoma versus T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Diagnostic Challenge. ( 25110597 )
2014
13
Hemophagocytic lymphohistiocytosis secondary to T-cell/histiocyte-rich large B-cell lymphoma. ( 24955327 )
2014
14
Anti-erythropoietin receptor antibody-associated pure red cell aplasia accompanied by Coombs-negative autoimmune hemolytic anemia in a patient with T cell/histiocyte-rich large B cell lymphoma. ( 25096221 )
2014
15
Fatal necrotizing angiotropic Epstein-Barr virus-negative large B-cell lymphoma: a case report with unusual clinicopathological features in-between lymphomatoid granulomatosis and T-cell/histiocyte-rich large B-cell lymphoma. ( 25546693 )
2014
16
Diagnosis of primary pulmonary T- cell/histiocyte-rich large B cell lymphoma with tissue eosinophilia via clinicopathological observation and molecular assay. ( 25273521 )
2014
17
Upregulation of innate immune responses in a T cell/histiocyte-rich large B cell lymphoma patient with significant autoimmune disorders mimicking systemic lupus erythematosus. ( 23743539 )
2014
18
T-cell/histiocyte-rich large B-cell lymphoma--transformation of nodular lymphocyte predominant Hodgkin lymphoma in the bone marrow. ( 24483596 )
2014
19
T-cell/histiocyte-rich large B-cell lymphoma with zonal expansion of fibroblastic reticulum cells and infiltration by a subpopulation of myeloperoxidase positive histiocytes. ( 25042387 )
2014
20
Does functional imaging distinguish nodular lymphocyte-predominant hodgkin lymphoma from T-cell/histiocyte-rich large B-cell lymphoma? ( 23773450 )
2013
21
First case of T-cell/histiocyte-rich-large B-cell lymphoma presenting with duodenal obstruction. ( 24345670 )
2013
22
Matched-Pair Analysis Comparing the Outcomes of T Cell/Histiocyte-Rich Large B Cell Lymphoma and Diffuse Large B Cell Lymphoma in Patients Treated with Rituximab-CHOP. ( 24192382 )
2013
23
Multiple cytokine- and chemokine-producing T-cell/histiocyte-rich large B-cell lymphoma. ( 23278285 )
2013
24
Nodular lymphocyte predominant hodgkin lymphoma and T cell/histiocyte rich large B cell lymphoma - endpoints of a spectrum of one disease? ( 24244368 )
2013
25
T-cell/histiocyte-rich large B-cell lymphoma of the thyroid. ( 23298413 )
2013
26
Primary bone marrow T-cell/histiocyte-rich large B-cell lymphoma: a diagnostic challenge. ( 23562349 )
2013
27
Macrophages in T cell/histiocyte rich large B cell lymphoma strongly express metal-binding proteins and show a bi-activated phenotype. ( 23686423 )
2013
28
Extranodal T-cell/histiocyte-rich large B-cell lymphoma presenting primarily on the skin. ( 22948794 )
2012
29
Primary T cell/histiocyte-rich large B-cell lymphoma of the orbit. ( 20562665 )
2011
30
T cell/histiocyte-rich large B-cell lymphoma: an update on its biology and classification. ( 22081105 )
2011
31
T-cell/histiocyte-rich large B-cell lymphoma shows transcriptional features suggestive of a tolerogenic host immune response. ( 19797726 )
2010
32
T-cell/histiocyte-rich large B-cell lymphoma. ( 20207840 )
2010
33
Nodular lymphocyte-predominant Hodgkin lymphoma and T cell histiocyte-rich large B cell lymphoma: diagnosis in two monozygotic twins. ( 20653789 )
2010
34
Splenic micronodular T-cell/histiocyte-rich large B-cell lymphoma: effect of prior corticosteroid therapy. ( 19763612 )
2009
35
Splenic micronodular T-cell/histiocyte-rich large B-cell lymphoma. ( 18620998 )
2008
36
Nodular lymphocyte-predominant hodgkin lymphoma or T-cell/histiocyte rich large B-cell lymphoma: the problem in "grey zone" lymphomas. ( 18784812 )
2008
37
Morphologic, immunphenotypic and clinical discriminators between T-cell/histiocyte-rich large B-cell lymphoma and lymphocyte-predominant Hodgkin lymphoma. ( 20063524 )
2008
38
T-cell/histiocyte-rich large B-cell lymphoma associated with a near-tetraploid karyotype and complex genetic abnormalities. ( 16856972 )
2006
39
T-cell/histiocyte-rich large B-cell lymphoma displays a heterogeneity similar to diffuse large B-cell lymphoma: a clinicopathologic, immunohistochemical, and molecular study of 30 cases. ( 15894921 )
2005
40
Pediatric EBV-positive T-cell/histiocyte-rich large B-cell lymphoma with clonal cells in the bone marrow without overt involvement. ( 15621841 )
2005
41
Micronodular T-cell/histiocyte-rich large B-cell lymphoma of the spleen: histology, immunophenotype, and differential diagnosis. ( 12826882 )
2003
42
T-cell/histiocyte-rich large B-cell lymphoma: a heterogeneous entity with derivation from germinal center B cells. ( 12409722 )
2002
43
T-cell/histiocyte-rich large B-cell lymphoma: a distinct clinicopathologic entity. ( 11870169 )
2002
44
CD5+ T-cell/histiocyte-rich large B-cell lymphoma. ( 12379751 )
2002
45
T-cell/histiocyte-rich large B-cell lymphoma is a disseminated aggressive neoplasm: differential diagnosis from Hodgkin's lymphoma. ( 12207783 )
2002

Variations for T-Cell/histiocyte Rich Large B Cell Lymphoma

Expression for T-Cell/histiocyte Rich Large B Cell Lymphoma

Search GEO for disease gene expression data for T-Cell/histiocyte Rich Large B Cell Lymphoma.

Pathways for T-Cell/histiocyte Rich Large B Cell Lymphoma

GO Terms for T-Cell/histiocyte Rich Large B Cell Lymphoma

Biological processes related to T-Cell/histiocyte Rich Large B Cell Lymphoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein import into nucleus, translocation GO:0000060 8.96 BCL6 IFNG
2 complement receptor mediated signaling pathway GO:0002430 8.62 CR1 CR2

Sources for T-Cell/histiocyte Rich Large B Cell Lymphoma

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70 UMLS via Orphanet
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