MCID: TCL002
MIFTS: 43

T-Cell Large Granular Lymphocyte Leukemia

Categories: Cancer diseases, Immune diseases, Blood diseases

Aliases & Classifications for T-Cell Large Granular Lymphocyte Leukemia

MalaCards integrated aliases for T-Cell Large Granular Lymphocyte Leukemia:

Name: T-Cell Large Granular Lymphocyte Leukemia 12 14 69
Leukemia, Large Granular Lymphocytic 69
Large Granular Lymphocytic Leukemia 12
Leukemia Lymphocytic Large Granular 52

Classifications:



External Ids:

Disease Ontology 12 DOID:0050751

Summaries for T-Cell Large Granular Lymphocyte Leukemia

Disease Ontology : 12 A chronic lymphocytic leukemia that exhibits an unexplained, chronic (> 6 months) elevation in large granular lymphocytes (LGLs) in the peripheral blood.

MalaCards based summary : T-Cell Large Granular Lymphocyte Leukemia, also known as leukemia, large granular lymphocytic, is related to systemic lupus erythematosus and large granular lymphocyte leukemia. An important gene associated with T-Cell Large Granular Lymphocyte Leukemia is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Cefepime and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and digestive/alimentary

Wikipedia : 72 Large granular lymphocytic (LGL) leukemia is a chronic lymphoproliferative disorder that exhibits an... more...

Related Diseases for T-Cell Large Granular Lymphocyte Leukemia

Diseases related to T-Cell Large Granular Lymphocyte Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
id Related Disease Score Top Affiliating Genes
1 systemic lupus erythematosus 28.4 FASLG IL18 IL2 IL2RA
2 large granular lymphocyte leukemia 11.8
3 leukemia 10.9
4 autoimmune lymphoproliferative syndrome due to ctla4 haploinsuffiency 10.5 IL2RA STAT3
5 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 10.5 IL2RA MICA
6 deafness, autosomal recessive 67 10.3 IL18 MICA
7 lymphoma 10.3
8 laryngeal papillomatosis 10.2 IL2RA MICA STAT3
9 duodenal somatostatinoma 10.2 FASLG NCAM1
10 spinal cancer 10.2 FASLG GZMB
11 gastrointestinal tuberculosis 10.2 FASLG GZMB
12 testicular germ cell cancer 10.2 FASLG GZMB
13 hepatosplenic t-cell lymphoma 10.2
14 pure red-cell aplasia 10.2
15 macrocephaly, mental retardation, short stature, spastic paraplegia and cns malformations 10.2 FASLG GZMB
16 hypoglycemia 10.1 GZMB NCAM1
17 succinic acidemia lactic acidosis congenital 10.1 GZMB NCAM1
18 iida kannari syndrome 10.1 FASLG IL2RA
19 neutropenia 10.1
20 splenomegaly 10.1
21 t-cell prolymphocytic leukemia 10.1
22 heavy chain disease 10.1
23 gamma heavy chain disease 10.1
24 rheumatoid arthritis 10.1
25 prolymphocytic leukemia 10.1
26 myelodysplastic syndrome 10.1
27 arthritis 10.1
28 t-cell leukemia 10.1
29 vulvar nodular hidradenoma 10.0 IL18 IL2RA STAT3
30 cpt deficiency, hepatic, type ia 10.0 MICA NCAM1 STAT3
31 graft-versus-host disease, protection against 10.0 IL2 IL2RA
32 villoglandular endometrial endometrioid adenocarcinoma 10.0 GZMB NCAM1
33 mixed cell type cancer 10.0 GZMB NCAM1
34 barbiturate dependence 10.0 IL2 IL2RA
35 screw worm infectious disease 10.0 FASLG GZMB
36 sarcoidosis 1 10.0 GZMB MICA STAT3
37 parametritis 10.0 IL2 IL2RA
38 hemophagocytic lymphohistiocytosis 10.0 IL2 KIR2DL1
39 reardon wilson cavanagh syndrome 10.0 GZMB IL18
40 cyclosporiasis 9.9 IL2 IL2RA
41 brain injury 9.9 IL2 STAT3
42 chronic graft versus host disease 9.9
43 human t-cell leukemia virus type 1 9.9
44 peripheral t-cell lymphoma 9.9
45 good syndrome 9.9
46 protein-losing enteropathy 9.9
47 sjogren's syndrome 9.9
48 anaplastic large cell lymphoma 9.9
49 essential thrombocythemia 9.9
50 chronic myelomonocytic leukemia 9.9

Graphical network of the top 20 diseases related to T-Cell Large Granular Lymphocyte Leukemia:



Diseases related to T-Cell Large Granular Lymphocyte Leukemia

Symptoms & Phenotypes for T-Cell Large Granular Lymphocyte Leukemia

GenomeRNAi Phenotypes related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.28 GZMB IL18 IL2 IL2RA
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.28 IL18 IL2 IL2RA FASLG GZMB

MGI Mouse Phenotypes related to T-Cell Large Granular Lymphocyte Leukemia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.35 FASLG IL18 IL2 IL2RA STAT3
2 vision/eye MP:0005391 9.1 IL2 IL2RA NCAM1 STAT3 FASLG IL18

Drugs & Therapeutics for T-Cell Large Granular Lymphocyte Leukemia

Drugs for T-Cell Large Granular Lymphocyte Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 236)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefepime Approved Phase 3 88040-23-7 5479537
2
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
3
Ofloxacin Approved Phase 3 82419-36-1 4583
4
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
5
Carboplatin Approved Phase 2, Phase 3,Phase 1 41575-94-4 10339178 498142 38904
6
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
7
Darbepoetin alfa Approved, Investigational Phase 3,Phase 2 11096-26-7, 209810-58-2
8
Iron Approved Phase 3,Phase 1,Phase 2 7439-89-6 23925
9
Dextromethorphan Approved Phase 3 125-71-3 5360696 5362449
10
Guaifenesin Approved, Vet_approved Phase 3,Phase 2 93-14-1 3516
11
Morphine Approved, Investigational Phase 3 57-27-2 5288826
12
Ondansetron Approved Phase 3 99614-02-5 4595
13
Dalteparin Approved Phase 3 9005-49-6
14
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
15
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
16
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
17
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
18
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
19
Busulfan Approved, Investigational Phase 2, Phase 3,Early Phase 1 55-98-1 2478
20
Etoposide Approved Phase 2, Phase 3,Phase 1,Early Phase 1 33419-42-0 36462
21
Fludarabine Approved Phase 2, Phase 3, Phase 1 21679-14-1, 75607-67-9 30751
22 Thiotepa Approved Phase 2, Phase 3,Phase 1 52-24-4 5453
23
Melphalan Approved Phase 2, Phase 3 148-82-3 4053 460612
24
Ginseng Approved, Nutraceutical Phase 3 50647-08-0
25 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
26 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
27 Anti-Infective Agents Phase 3,Phase 2,Phase 1
28 Cephalosporins Phase 3
29 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
30 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 1,Phase 2
31 Renal Agents Phase 3,Phase 1,Phase 2
32 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
33 Analgesics Phase 3,Phase 2
34 Anesthetics Phase 3
35 Anesthetics, Dissociative Phase 3
36 Anesthetics, General Phase 3
37 Anesthetics, Intravenous Phase 3
38 Central Nervous System Depressants Phase 3,Phase 1,Phase 2
39 Excitatory Amino Acid Antagonists Phase 3
40 Excitatory Amino Acids Phase 3
41 Neurotransmitter Agents Phase 3,Phase 1
42 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
43 Alkylating Agents Phase 2, Phase 3,Phase 1,Early Phase 1
44 Antirheumatic Agents Phase 2, Phase 3,Phase 1,Early Phase 1
45 Immunosuppressive Agents Phase 2, Phase 3,Phase 1,Early Phase 1
46 Ferric Compounds Phase 3
47 ferric gluconate Phase 3
48 Hematinics Phase 3,Phase 2
49 Analgesics, Opioid Phase 3
50 Antitussive Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 124)

id Name Status NCT ID Phase Drugs
1 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
2 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
3 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3 American ginseng
4 Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
5 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
6 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3 ondansetron
7 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
8 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
9 Darbepoetin Alfa Compared With Epoetin Alfa in Treating Anemia in Patients Receiving Chemotherapy for Cancer Completed NCT00070382 Phase 3 darbepoetin alfa;epoetin alfa
10 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3 Fragmin
11 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
12 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
13 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
14 Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer Active, not recruiting NCT00003816 Phase 2, Phase 3 busulfan;carboplatin;cyclophosphamide;etoposide;fludarabine phosphate;melphalan;thiotepa
15 Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas Unknown status NCT01805037 Phase 1, Phase 2 brentuximab vedotin
16 Cyclosporine in Treating Patients With Low Blood Counts Caused By Hematologic Cancer Completed NCT00031980 Phase 2 cyclosporine
17 506U78 in Treating Patients With Chronic Lymphocytic Leukemia That Has Not Responded to Fludarabine or Alkylating Agents Completed NCT00003635 Phase 2 nelarabine
18 Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Completed NCT01093586 Phase 2 busulfan;cyclophosphamide;anti-thymocyte globulin;methylprednisolone;cyclosporine;mycophenolate mofetil
19 Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma Completed NCT01258998 Phase 2 Akt inhibitor MK2206
20 Combination Chemotherapy Followed By Alemtuzumab in Treating Patients With Chronic Lymphocytic Leukemia or Prolymphocytic Leukemia Completed NCT00278213 Phase 2 cyclophosphamide;fludarabine phosphate;mitoxantrone hydrochloride
21 Peripheral Stem Cell Transplantation in Treating Patients With Breast Cancer or Hematologic Cancer Completed NCT00006225 Phase 1, Phase 2
22 Doxorubicin Hydrochloride Liposome and Bortezomib in Treating Patients With Refractory Hematologic Cancer or Malignant Solid Tumor or Metastatic Breast Cancer Completed NCT00237627 Phase 1, Phase 2 PS-341;Doxil;Velcade
23 Epoetin Alfa or Darbepoetin Alfa in Treating Patients With Anemia Caused by Chemotherapy Completed NCT00416624 Phase 2 darbepoetin alfa;epoetin alfa
24 Epoetin Alfa in Treating Patients With Anemia Who Are Undergoing Chemotherapy for Cancer Completed NCT00255749 Phase 2
25 Donor Natural Killer Cells After Donor Stem Cell Transplant in Treating Patients With Advanced Cancer Completed NCT00823524 Phase 1, Phase 2
26 Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Refractory Cancer Completed NCT00003406 Phase 1, Phase 2 carboplatin;docetaxel;ifosfamide
27 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00005804 Phase 2 cyclophosphamide
28 Interleukin-2 Plus Interferon Alfa in Treating Adults With Metastatic Cancer Completed NCT00002504 Phase 2
29 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2 caspofungin acetate
30 Prospective, Multicentric, Phase II Randomized Controlled Trial on Two Parallel Groups Comparing the Efficacy of Two Immunosuppressive Drugs (Methotrexate, Cyclophosphamide) in Large Granular Lymphocytes Leukemia Recruiting NCT01976182 Phase 2 Methotrexate;Cyclophosphamide
31 Alemtuzumab (Campath ) to Treat T-Large Granular Lymphocyte Leukemia Recruiting NCT00345345 Phase 2 Alemtuzumab (Campath)
32 Dasatinib for Immune Modulation After Donor Stem Cell Transplant for Hematologic Malignancies Recruiting NCT01643603 Phase 1, Phase 2 Dasatinib
33 Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies Recruiting NCT01839916 Phase 2
34 Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies Recruiting NCT01760655 Phase 2 Fludarabine phosphate;Thiotepa;Cyclophosphamide;Tacrolimus;Mycophenolate mofetil
35 A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies Recruiting NCT01384513 Phase 2 Fludarabine;Busulfan;Cyclophosphamide (CY);Tacrolimus;Mycophenolate mofetil
36 Biological Therapy in Treating Patients at High-Risk or With Lymphoma, Lymphoproliferative Disease, or Malignancies Recruiting NCT00002663 Phase 1, Phase 2
37 Dasatinib for Modulating Immune System After Autologous Stem Cell Transplants for Multiple Myeloma, Non-Hodgkin, or Hodgkin Lymphoma Recruiting NCT01609816 Phase 1, Phase 2 Dasatinib
38 CAR-pNK Cell Immunotherapy in CD7 Positive Leukemia and Lymphoma Recruiting NCT02742727 Phase 1, Phase 2
39 Fludarabine Phosphate, Radiation Therapy, and Rituximab in Treating Patients Who Are Undergoing Donor Stem Cell Transplant Followed by Rituximab for High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Active, not recruiting NCT00104858 Phase 2 Cyclosporine;Fludarabine Phosphate;Mycophenolate Mofetil
40 Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancer Active, not recruiting NCT00006251 Phase 1, Phase 2 fludarabine phosphate;cyclosporine;mycophenolate mofetil
41 Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant Active, not recruiting NCT00078858 Phase 1, Phase 2 fludarabine phosphate;cyclosporine;mycophenolate mofetil
42 Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Active, not recruiting NCT01529827 Phase 2 fludarabine phosphate;melphalan;tacrolimus;mycophenolate mofetil;methotrexate
43 Alemtuzumab, Fludarabine Phosphate, and Low-Dose Total Body Irradiation Before Donor Stem Cell Transplantation in Treating Patients With Hematological Malignancies Active, not recruiting NCT00040846 Phase 2 fludarabine phosphate;mycophenolate mofetil;cyclosporine
44 A Dose-Ranging Study of IV BNZ-1 in LGL Leukemia or Refractory CTCL Not yet recruiting NCT03239392 Phase 1, Phase 2 BNZ132-1-40
45 Methotrexate Followed by Fludarabine in Patients With T-Cell Large Granular Lymphocytic Leukemia Terminated NCT00278265 Phase 2 MTX followed by fludarabine
46 Effect of Cyclosporine Therapy on Gene Expression in Patients With Large Granular Lymphocyte Leukemia Terminated NCT00363779 Phase 2 Cyclosporine
47 Tipifarnib in Treating Patients With Anemia or Neutropenia and Large Granular Lymphocyte Leukemia Terminated NCT00360776 Phase 2 tipifarnib
48 Alemtuzumab in Myelodysplastic Syndrome (MDS), Aplastic Anemia, and T-Cell Large Granular Lymphocytic Leukemia (T-GL) Terminated NCT01191749 Phase 2 Alemtuzumab
49 Lenalidomide With or Without Rituximab in Treating Patients With Progressive or Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Prolymphocytic Leukemia, or Non-Hodgkin Lymphoma Previously Treated With Donor Stem Cell Transplant Terminated NCT01419795 Phase 2 lenalidomide
50 Methotrexate With or Without Cyclophosphamide in Treating Patients With Lymphocytic Leukemia Terminated NCT00003910 Phase 2 Cyclophosphamide;Methotrexate;Prednisone

Search NIH Clinical Center for T-Cell Large Granular Lymphocyte Leukemia

Genetic Tests for T-Cell Large Granular Lymphocyte Leukemia

Anatomical Context for T-Cell Large Granular Lymphocyte Leukemia

MalaCards organs/tissues related to T-Cell Large Granular Lymphocyte Leukemia:

39
T Cells, Bone, Bone Marrow, Liver, Kidney, B Cells, Colon

Publications for T-Cell Large Granular Lymphocyte Leukemia

Articles related to T-Cell Large Granular Lymphocyte Leukemia:

(show top 50) (show all 74)
id Title Authors Year
1
Distinguishing Between Hepatosplenic T-cell Lymphoma and I^I' T-cell Large Granular Lymphocytic Leukemia: A Clinicopathologic, Immunophenotypic, and Molecular Analysis. ( 27755009 )
2017
2
Dysregulated signaling, proliferation and apoptosis impact on the pathogenesis of TCRI^I'+ T cell large granular lymphocyte leukemia. ( 28407008 )
2017
3
Donor-Derived T-Cell Large Granular Lymphocytic Leukemia in a Patient With Peripheral T-Cell Lymphoma. ( 27496109 )
2016
4
Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia. ( 26199174 )
2016
5
High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia. ( 27697773 )
2016
6
Gamma Heavy Chain Disease with T-cell Large Granular Lymphocytic Leukemia: A Case Report and Review of the Literature. ( 26875967 )
2016
7
Moderate-dose cyclophosphamide in the treatment of relapsed/refractory T-cell large granular lymphocytic leukemia-associated pure red cell aplasia. ( 27077768 )
2016
8
Hematopoietic stem cell transplantation for T-cell large granular lymphocyte leukemia: a retrospective study of the European Society for Blood and Marrow Transplantation. ( 26460210 )
2015
9
Good syndrome presenting with CD8+ T-Cell large granular lymphocyte leukemia. ( 26429871 )
2015
10
T-Cell Large Granular Lymphocyte Leukemia in the Lower Eyelid. ( 25198396 )
2014
11
Distinct effect of cyclophosphamide and cyclosporine on pure red cell aplasia associated with T-cell large granular lymphocyte leukemia. ( 25466263 )
2014
12
Acquired inhibitors to factor VIII and fibrinogen in the setting of T-cell large granular lymphocyte leukemia: a case report and review of the literature. ( 25396761 )
2014
13
Concurrent administration of darbepoetin alfa, cyclosporine A, and prednisolone is useful for T cell large granular lymphocyte leukemia associated with myelodysplastic syndrome complicated by Coombs-negative hemolytic anemia. ( 24756696 )
2014
14
Submicroscopic genomic rearrangements change gene expression in T-cell large granular lymphocyte leukemia. ( 24649974 )
2014
15
Lack of common TCRA and TCRB clonotypes in CD8(+)/TCRI+I^(+) T-cell large granular lymphocyte leukemia: a review on the role of antigenic selection in the immunopathogenesis of CD8(+) T-LGL. ( 24413066 )
2014
16
Coexistence of ALK-anaplastic large cell lymphoma and CD4+ T cell large granular lymphocytic leukemia. ( 25100004 )
2014
17
T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: Metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities. ( 25238936 )
2014
18
CD4(-)/CD8(-) variant of T-cell large granular lymphocytic leukemia or hepatosplenic T-cell lymphoma: a clinicopathologic dilemma. ( 23800602 )
2013
19
Treatment of T-cell large granular lymphocyte leukemia with cyclosporine A: experience in a Chinese single institution. ( 23395383 )
2013
20
Unusual concurrence of T-cell large granular lymphocytic leukemia with Franklin disease (gamma heavy chain disease) manifested with massive splenomegaly. ( 22694793 )
2013
21
STAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia. ( 24283217 )
2013
22
Long-term remission of T-cell large granular lymphocyte leukemia associated with rheumatoid arthritis after rituximab therapy. ( 23869084 )
2013
23
T-cell large granular lymphocyte leukemia in a child with anemia and Crohn's disease. ( 23409990 )
2013
24
STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia. ( 23563237 )
2013
25
Differential diagnosis of CD4-/CD8- I^I' T-cell large granular lymphocytic leukemia and hepatosplenic T-cell lymphoma. ( 22338065 )
2012
26
Lymphocytosis: T-cell large granular lymphocyte leukemia. ( 23082329 )
2012
27
Asymptomatic T-cell large granular lymphocyte leukemia with an unusual immunophenotype. ( 24765467 )
2012
28
STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. ( 22859607 )
2012
29
Increased serum soluble IL-15RI+ levels in T-cell large granular lymphocyte leukemia. ( 22049515 )
2012
30
Imatinib mesylate in T-cell large granular lymphocyte leukemia associated with chronic graft-versus-host disease. ( 21663506 )
2011
31
A case report: Concurrent chronic myelomonocytic leukemia and T-cell large granular lymphocytic leukemia-type clonal proliferation as detected by multiparametric flow cytometry. ( 21337493 )
2011
32
A case of concomitant T-cell large granular lymphocyte leukemia and plasma cell myeloma. ( 22252668 )
2011
33
Bone marrow failure due to T-cell large granular lymphocytic leukemia in a patient with essential thrombocythemia. ( 20934219 )
2011
34
CD20dim-positive T-cell large granular lymphocytic leukemia in a patient with concurrent hairy cell leukemia and plasma cell myeloma. ( 21151394 )
2010
35
Lessons learned from an unusual presentation of CD3+, CD56- T-cell large granular lymphocyte leukemia. ( 20679608 )
2010
36
T-cell large granular lymphocyte leukemia: an Asian perspective. ( 20084380 )
2010
37
A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia. ( 19660811 )
2010
38
Rapid and durable molecular response of refractory T-cell large granular lymphocyte leukemia after alemtuzumab treatment. ( 20211489 )
2010
39
MICA polymorphism identified by whole genome array associated with NKG2D-mediated cytotoxicity in T-cell large granular lymphocyte leukemia. ( 20460636 )
2010
40
Long-term safety and efficacy of cyclosporin A therapy for T-cell large granular lymphocyte leukemia. ( 20038217 )
2010
41
T-cell large granular lymphocyte leukemia associated with myelodysplastic syndrome: a clinicopathologic study of nine cases. ( 19228641 )
2009
42
Protein-losing enteropathy due to T-cell large granular lymphocyte leukemia. ( 19307498 )
2009
43
T-cell large granular lymphocyte leukemia presenting as end-stage renal disease: the diagnostic role of flow-cytometric and clonality analysis of the urine sediment. ( 19203516 )
2009
44
T cell large granular lymphocyte leukemia associated with rheumatoid arthritis and neutropenia. ( 19394280 )
2009
45
CD20-positive T-cell large granular lymphocyte leukemia: case report and review of the literature. ( 19687595 )
2009
46
Outcomes of splenectomy in T-cell large granular lymphocyte leukemia with splenomegaly and cytopenia. ( 18550263 )
2008
47
The gammadelta variant of T cell large granular lymphocyte leukemia is very similar to the common alphabeta type: report of two cases. ( 19669213 )
2008
48
Fludarabine, mitoxantrone and dexamethasone as first-line treatment for T-cell large granular lymphocyte leukemia. ( 17525720 )
2007
49
CD20- and CD56-positive T-cell large granular lymphocyte leukemia in a human T-cell leukemia virus type 1 carrier. ( 18055343 )
2007
50
T-cell large granular lymphocyte leukemia of donor origin after cord blood transplantation. ( 17875238 )
2007

Variations for T-Cell Large Granular Lymphocyte Leukemia

Expression for T-Cell Large Granular Lymphocyte Leukemia

Search GEO for disease gene expression data for T-Cell Large Granular Lymphocyte Leukemia.

Pathways for T-Cell Large Granular Lymphocyte Leukemia

Pathways related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

(show all 31)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 FASLG IL18 IL2 IL2RA KIR2DL1 MICA
2
Show member pathways
13.17 FASLG IL18 IL2 IL2RA STAT3
3
Show member pathways
13.08 FASLG IL18 IL2 IL2RA NCAM1 STAT3
4
Show member pathways
12.62 FASLG GZMB IL2 IL2RA KIR2DL1 MICA
5
Show member pathways
12.55 FASLG IL18 IL2 IL2RA STAT3
6
Show member pathways
12.38 IL18 IL2 IL2RA STAT3
7
Show member pathways
12.31 FASLG GZMB IL2 KIR2DL1 MICA
8 12.23 FASLG GZMB IL2 IL2RA NCAM1 STAT3
9
Show member pathways
12.01 IL2 IL2RA STAT3
10
Show member pathways
11.89 IL2 IL2RA STAT3
11
Show member pathways
11.85 IL2 IL2RA STAT3
12 11.81 IL2 IL2RA NCAM1
13 11.79 FASLG IL18 STAT3
14
Show member pathways
11.75 IL18 IL2 STAT3
15 11.71 IL2 IL2RA STAT3
16
Show member pathways
11.57 FASLG IL2 IL2RA
17
Show member pathways
11.48 FASLG IL2 IL2RA
18
Show member pathways
11.45 FASLG GZMB IL2 IL2RA
19 11.36 FASLG STAT3
20 11.35 FASLG IL2
21 11.33 IL18 STAT3
22 11.31 IL2 IL2RA
23
Show member pathways
11.28 IL2RA STAT3
24 11.26 GZMB IL18 IL2 IL2RA NCAM1
25
Show member pathways
11.22 FASLG GZMB IL2 IL2RA
26 11.17 FASLG IL18
27
Show member pathways
11.15 FASLG GZMB IL18 IL2 IL2RA STAT3
28 11.14 IL2 IL2RA
29
Show member pathways
11.07 IL2RA STAT3
30 11.01 FASLG IL18 IL2
31 10.9 IL18 IL2 IL2RA STAT3

GO Terms for T-Cell Large Granular Lymphocyte Leukemia

Cellular components related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 FASLG IL2RA NCAM1
2 cell surface GO:0009986 8.92 FASLG IL2RA MICA NCAM1

Biological processes related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.62 IL18 IL2 IL2RA NCAM1
2 positive regulation of interferon-gamma production GO:0032729 9.52 IL18 IL2
3 cytolysis GO:0019835 9.51 GZMB MICA
4 natural killer cell activation GO:0030101 9.49 IL18 IL2
5 natural killer cell mediated cytotoxicity GO:0042267 9.48 GZMB MICA
6 positive regulation of T cell differentiation GO:0045582 9.46 IL2 IL2RA
7 positive regulation of interleukin-17 production GO:0032740 9.43 IL18 IL2
8 negative regulation of lymphocyte proliferation GO:0050672 9.4 IL2 IL2RA
9 positive regulation of tissue remodeling GO:0034105 9.37 IL18 IL2
10 immune response GO:0006955 9.35 FASLG IL18 IL2 IL2RA KIR2DL1
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.26 IL18 IL2
12 regulation of T cell homeostatic proliferation GO:0046013 9.16 IL2 IL2RA
13 positive regulation of activated T cell proliferation GO:0042104 8.8 IL18 IL2 IL2RA

Molecular functions related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 FASLG IL18 IL2
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.8 IL2 IL2RA NCAM1

Sources for T-Cell Large Granular Lymphocyte Leukemia

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