MCID: TCL002
MIFTS: 48

T-Cell Large Granular Lymphocyte Leukemia

Categories: Cancer diseases, Immune diseases, Blood diseases

Aliases & Classifications for T-Cell Large Granular Lymphocyte Leukemia

MalaCards integrated aliases for T-Cell Large Granular Lymphocyte Leukemia:

Name: T-Cell Large Granular Lymphocyte Leukemia 12 14 69
Leukemia, Large Granular Lymphocytic 69
Large Granular Lymphocytic Leukemia 12
Leukemia Lymphocytic Large Granular 51

Classifications:



External Ids:

Disease Ontology 12 DOID:0050751

Summaries for T-Cell Large Granular Lymphocyte Leukemia

Disease Ontology : 12 A chronic lymphocytic leukemia that exhibits an unexplained, chronic (> 6 months) elevation in large granular lymphocytes (LGLs) in the peripheral blood.

MalaCards based summary : T-Cell Large Granular Lymphocyte Leukemia, also known as leukemia, large granular lymphocytic, is related to large granular lymphocyte leukemia and pure red-cell aplasia. An important gene associated with T-Cell Large Granular Lymphocyte Leukemia is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Ketamine and Cefepime have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow, and related phenotype is vision/eye.

Wikipedia : 72 Large granular lymphocytic (LGL) leukemia is a chronic lymphoproliferative disorder that exhibits an... more...

Related Diseases for T-Cell Large Granular Lymphocyte Leukemia

Diseases related to T-Cell Large Granular Lymphocyte Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 large granular lymphocyte leukemia 33.6 STAT3 STAT5B
2 pure red-cell aplasia 30.5 IL2 STAT3
3 b-cell expansion with nfkb and t-cell anergy 29.8 FASLG GZMB IL2
4 graft-versus-host disease 29.6 FASLG GZMB IL2
5 leukemia 10.9
6 lymphoma 10.4
7 cellular congenital mesoblastic nephroma 10.4 STAT3 STAT5B
8 hepatosplenic t-cell lymphoma 10.2
9 breast medullary carcinoma 10.2 FASLG GZMB
10 lymphocytic gastritis 10.2 FASLG GZMB
11 chronic nk-cell lymphocytosis 10.2 FASLG NCAM1
12 orbit lymphoma 10.2 GZMB NCAM1
13 immune suppression 10.1 IL2 STAT3
14 rheumatoid arthritis 10.1
15 myelodysplastic syndrome 10.1
16 autoimmune lymphoproliferative syndrome, type v 10.1
17 arthritis 10.1
18 neutropenia 10.1
19 heavy chain disease 10.1
20 gamma heavy chain disease 10.1
21 prolymphocytic leukemia 10.1
22 t-cell leukemia 10.1
23 splenomegaly 10.1
24 t-cell prolymphocytic leukemia 10.1
25 subcutaneous panniculitis-like t-cell lymphoma 10.1 GZMB NCAM1
26 choriocarcinoma of the testis 10.1 FASLG GZMB
27 lymphomatoid papulosis 10.1 FASLG GZMB
28 jak3-deficient severe combined immunodeficiency 10.1 IL2 STAT5B
29 supratentorial primitive neuroectodermal tumor 10.1 IER3IP1 NCAM1
30 lung lymphoma 10.0 GZMB NCAM1
31 bone fracture 10.0 IL2 STAT3
32 panniculitis 10.0 GZMB NCAM1
33 sialolithiasis 10.0 FASLG GZMB
34 systemic lupus erythematosus 10.0
35 sjogren syndrome 10.0
36 aging 10.0
37 polyarteritis nodosa, childhood-onset 10.0
38 anaplastic large cell lymphoma 10.0
39 b-cell lymphomas 10.0
40 chronic myelomonocytic leukemia 10.0
41 crohn's disease 10.0
42 hematopoietic stem cell transplantation 10.0
43 hemolytic anemia 10.0
44 peripheral t-cell lymphoma 10.0
45 good syndrome 10.0
46 lymphoblastic leukemia 10.0
47 protein-losing enteropathy 10.0
48 essential thrombocythemia 10.0
49 hairy cell leukemia 10.0
50 neuropathy 10.0

Graphical network of the top 20 diseases related to T-Cell Large Granular Lymphocyte Leukemia:



Diseases related to T-Cell Large Granular Lymphocyte Leukemia

Symptoms & Phenotypes for T-Cell Large Granular Lymphocyte Leukemia

MGI Mouse Phenotypes related to T-Cell Large Granular Lymphocyte Leukemia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.02 FASLG IL18 IL2 NCAM1 STAT3

Drugs & Therapeutics for T-Cell Large Granular Lymphocyte Leukemia

Drugs for T-Cell Large Granular Lymphocyte Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 236)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
2
Cefepime Approved, Investigational Phase 3 88040-23-7 5479537
3
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
4
Ofloxacin Approved Phase 3 82419-36-1 4583
5
Carboplatin Approved Phase 2, Phase 3,Phase 1 41575-94-4 10339178 38904 498142
6
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
7
Darbepoetin alfa Approved, Investigational Phase 3,Phase 2 209810-58-2, 11096-26-7
8
Iron Approved Phase 3,Phase 1,Phase 2 7439-89-6 23925
9
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
10
Dalteparin Approved Phase 3 9005-49-6
11
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
12
Ondansetron Approved Phase 3 99614-02-5 4595
13
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
14
Caspofungin Approved Phase 3,Phase 2 162808-62-0, 179463-17-3 2826718 468682
15
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
16
Dextromethorphan Approved Phase 3 125-71-3 5362449 5360696
17
Guaifenesin Approved, Investigational, Vet_approved Phase 3,Phase 2 93-14-1 3516
18
Morphine Approved, Investigational Phase 3 57-27-2 5288826
19
Busulfan Approved, Investigational Phase 2, Phase 3,Early Phase 1 55-98-1 2478
20
Etoposide Approved Phase 2, Phase 3,Phase 1,Early Phase 1 33419-42-0 36462
21
Fludarabine Approved Phase 2, Phase 3, Phase 1 21679-14-1, 75607-67-9 30751
22 Thiotepa Approved, Investigational Phase 2, Phase 3,Phase 1 52-24-4 5453
23
Melphalan Approved Phase 2, Phase 3 148-82-3 460612 4053
24
Ginseng Approved, Investigational, Nutraceutical Phase 3 50647-08-0
25 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
26 Analgesics Phase 3,Phase 2
27 Anesthetics Phase 3
28 Anesthetics, Dissociative Phase 3
29 Anesthetics, General Phase 3
30 Anesthetics, Intravenous Phase 3
31 Central Nervous System Depressants Phase 3,Phase 1,Phase 2
32 Excitatory Amino Acid Antagonists Phase 3
33 Excitatory Amino Acids Phase 3
34 Neurotransmitter Agents Phase 3,Phase 1
35 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
36 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
37 Anti-Infective Agents Phase 3,Phase 2,Phase 1
38 Cephalosporins Phase 3
39 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
40 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 1,Phase 2
41 Renal Agents Phase 3,Phase 1,Phase 2
42 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
43 Alkylating Agents Phase 2, Phase 3,Phase 1,Early Phase 1
44 Antirheumatic Agents Phase 2, Phase 3,Phase 1,Early Phase 1
45 Immunosuppressive Agents Phase 2, Phase 3,Phase 1,Early Phase 1
46 Analgesics, Opioid Phase 3
47 Narcotics Phase 3
48 Ferric Compounds Phase 3
49 ferric gluconate Phase 3
50 Hematinics Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 124)

# Name Status NCT ID Phase Drugs
1 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
2 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
3 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
4 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3 American ginseng
5 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
6 Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
7 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
8 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3 Fragmin
9 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3 ondansetron
10 Darbepoetin Alfa Compared With Epoetin Alfa in Treating Anemia in Patients Receiving Chemotherapy for Cancer Completed NCT00070382 Phase 3 darbepoetin alfa;epoetin alfa
11 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
12 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
13 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
14 Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer Active, not recruiting NCT00003816 Phase 2, Phase 3 busulfan;carboplatin;cyclophosphamide;etoposide;fludarabine phosphate;melphalan;thiotepa
15 Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas Unknown status NCT01805037 Phase 1, Phase 2 brentuximab vedotin
16 Cyclosporine in Treating Patients With Low Blood Counts Caused By Hematologic Cancer Completed NCT00031980 Phase 2 cyclosporine
17 506U78 in Treating Patients With Chronic Lymphocytic Leukemia That Has Not Responded to Fludarabine or Alkylating Agents Completed NCT00003635 Phase 2 nelarabine
18 Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma Completed NCT01258998 Phase 2 Akt inhibitor MK2206
19 Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Completed NCT01093586 Phase 2 busulfan;cyclophosphamide;anti-thymocyte globulin;methylprednisolone;cyclosporine;mycophenolate mofetil
20 Donor Natural Killer Cells After Donor Stem Cell Transplant in Treating Patients With Advanced Cancer Completed NCT00823524 Phase 1, Phase 2
21 Epoetin Alfa or Darbepoetin Alfa in Treating Patients With Anemia Caused by Chemotherapy Completed NCT00416624 Phase 2 darbepoetin alfa;epoetin alfa
22 Combination Chemotherapy Followed By Alemtuzumab in Treating Patients With Chronic Lymphocytic Leukemia or Prolymphocytic Leukemia Completed NCT00278213 Phase 2 cyclophosphamide;fludarabine phosphate;mitoxantrone hydrochloride
23 Epoetin Alfa in Treating Patients With Anemia Who Are Undergoing Chemotherapy for Cancer Completed NCT00255749 Phase 2
24 Doxorubicin Hydrochloride Liposome and Bortezomib in Treating Patients With Refractory Hematologic Cancer or Malignant Solid Tumor or Metastatic Breast Cancer Completed NCT00237627 Phase 1, Phase 2 PS-341;Doxil;Velcade
25 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2 caspofungin acetate
26 Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Refractory Cancer Completed NCT00003406 Phase 1, Phase 2 carboplatin;docetaxel;ifosfamide
27 Interleukin-2 Plus Interferon Alfa in Treating Adults With Metastatic Cancer Completed NCT00002504 Phase 2
28 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00005804 Phase 2 cyclophosphamide
29 Peripheral Stem Cell Transplantation in Treating Patients With Breast Cancer or Hematologic Cancer Completed NCT00006225 Phase 1, Phase 2
30 Prospective, Multicentric, Phase II Randomized Controlled Trial on Two Parallel Groups Comparing the Efficacy of Two Immunosuppressive Drugs (Methotrexate, Cyclophosphamide) in Large Granular Lymphocytes Leukemia Recruiting NCT01976182 Phase 2 Methotrexate;Cyclophosphamide
31 A Dose-Ranging Study of IV BNZ-1 in LGL Leukemia or Refractory CTCL Recruiting NCT03239392 Phase 1, Phase 2 BNZ132-1-40
32 Dasatinib for Immune Modulation After Donor Stem Cell Transplant for Hematologic Malignancies Recruiting NCT01643603 Phase 1, Phase 2 Dasatinib
33 Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies Recruiting NCT01760655 Phase 2 Fludarabine phosphate;Thiotepa;Cyclophosphamide;Tacrolimus;Mycophenolate mofetil
34 A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies Recruiting NCT01384513 Phase 2 Fludarabine;Busulfan;Cyclophosphamide (CY);Tacrolimus;Mycophenolate mofetil
35 Dasatinib for Modulating Immune System After Autologous Stem Cell Transplants for Multiple Myeloma, Non-Hodgkin, or Hodgkin Lymphoma Recruiting NCT01609816 Phase 1, Phase 2 Dasatinib
36 CAR-pNK Cell Immunotherapy in CD7 Positive Leukemia and Lymphoma Recruiting NCT02742727 Phase 1, Phase 2
37 Biological Therapy in Treating Patients at High-Risk or With Lymphoma, Lymphoproliferative Disease, or Malignancies Recruiting NCT00002663 Phase 1, Phase 2
38 Alemtuzumab (Campath ) to Treat T-Large Granular Lymphocyte Leukemia Active, not recruiting NCT00345345 Phase 2 Alemtuzumab (Campath)
39 Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies Active, not recruiting NCT01839916 Phase 2
40 Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Active, not recruiting NCT01529827 Phase 2 fludarabine phosphate;melphalan;tacrolimus;mycophenolate mofetil;methotrexate
41 Fludarabine Phosphate, Radiation Therapy, and Rituximab in Treating Patients Who Are Undergoing Donor Stem Cell Transplant Followed by Rituximab for High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Active, not recruiting NCT00104858 Phase 2 Cyclosporine;Fludarabine Phosphate;Mycophenolate Mofetil
42 Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancer Active, not recruiting NCT00006251 Phase 1, Phase 2 fludarabine phosphate;cyclosporine;mycophenolate mofetil
43 Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant Active, not recruiting NCT00078858 Phase 1, Phase 2 fludarabine phosphate;cyclosporine;mycophenolate mofetil
44 Alemtuzumab, Fludarabine Phosphate, and Low-Dose Total Body Irradiation Before Donor Stem Cell Transplantation in Treating Patients With Hematological Malignancies Active, not recruiting NCT00040846 Phase 2 fludarabine phosphate;mycophenolate mofetil;cyclosporine
45 Effect of Cyclosporine Therapy on Gene Expression in Patients With Large Granular Lymphocyte Leukemia Terminated NCT00363779 Phase 2 Cyclosporine
46 Methotrexate Followed by Fludarabine in Patients With T-Cell Large Granular Lymphocytic Leukemia Terminated NCT00278265 Phase 2 MTX followed by fludarabine
47 Alemtuzumab in Myelodysplastic Syndrome (MDS), Aplastic Anemia, and T-Cell Large Granular Lymphocytic Leukemia (T-GL) Terminated NCT01191749 Phase 2 Alemtuzumab
48 Tipifarnib in Treating Patients With Anemia or Neutropenia and Large Granular Lymphocyte Leukemia Terminated NCT00360776 Phase 2 tipifarnib
49 Ipilimumab and Local Radiation Therapy in Treating Patients With Recurrent Melanoma, Non-Hodgkin Lymphoma, Colon, or Rectal Cancer Terminated NCT01769222 Phase 1, Phase 2
50 Lenalidomide With or Without Rituximab in Treating Patients With Progressive or Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Prolymphocytic Leukemia, or Non-Hodgkin Lymphoma Previously Treated With Donor Stem Cell Transplant Terminated NCT01419795 Phase 2 lenalidomide

Search NIH Clinical Center for T-Cell Large Granular Lymphocyte Leukemia

Genetic Tests for T-Cell Large Granular Lymphocyte Leukemia

Anatomical Context for T-Cell Large Granular Lymphocyte Leukemia

MalaCards organs/tissues related to T-Cell Large Granular Lymphocyte Leukemia:

38
T Cells, Bone, Bone Marrow, Liver, Kidney, B Cells, Colon

Publications for T-Cell Large Granular Lymphocyte Leukemia

Articles related to T-Cell Large Granular Lymphocyte Leukemia:

(show top 50) (show all 76)
# Title Authors Year
1
T-Cell Large Granular Lymphocytic Leukemia and Coexisting B-Cell Lymphomas: A Study From the Bone Marrow Pathology Group. ( 29365010 )
2018
2
Distinguishing Between Hepatosplenic T-cell Lymphoma and I^I' T-cell Large Granular Lymphocytic Leukemia: A Clinicopathologic, Immunophenotypic, and Molecular Analysis. ( 27755009 )
2017
3
Dysregulated signaling, proliferation and apoptosis impact on the pathogenesis of TCRI^I'+ T cell large granular lymphocyte leukemia. ( 28407008 )
2017
4
Donor derived T-cell large granular lymphocyte leukemia after cord blood transplant for pediatric T-cell lymphoblastic leukemia. ( 29269802 )
2017
5
High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia. ( 27697773 )
2016
6
Gamma Heavy Chain Disease with T-cell Large Granular Lymphocytic Leukemia: A Case Report and Review of the Literature. ( 26875967 )
2016
7
Donor-Derived T-Cell Large Granular Lymphocytic Leukemia in a Patient With Peripheral T-Cell Lymphoma. ( 27496109 )
2016
8
Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia. ( 26199174 )
2016
9
Moderate-dose cyclophosphamide in the treatment of relapsed/refractory T-cell large granular lymphocytic leukemia-associated pure red cell aplasia. ( 27077768 )
2016
10
Hematopoietic stem cell transplantation for T-cell large granular lymphocyte leukemia: a retrospective study of the European Society for Blood and Marrow Transplantation. ( 26460210 )
2015
11
Good syndrome presenting with CD8+ T-Cell large granular lymphocyte leukemia. ( 26429871 )
2015
12
Acquired inhibitors to factor VIII and fibrinogen in the setting of T-cell large granular lymphocyte leukemia: a case report and review of the literature. ( 25396761 )
2014
13
T-Cell Large Granular Lymphocyte Leukemia in the Lower Eyelid. ( 25198396 )
2014
14
Concurrent administration of darbepoetin alfa, cyclosporine A, and prednisolone is useful for T cell large granular lymphocyte leukemia associated with myelodysplastic syndrome complicated by Coombs-negative hemolytic anemia. ( 24756696 )
2014
15
Distinct effect of cyclophosphamide and cyclosporine on pure red cell aplasia associated with T-cell large granular lymphocyte leukemia. ( 25466263 )
2014
16
Coexistence of ALK-anaplastic large cell lymphoma and CD4+ T cell large granular lymphocytic leukemia. ( 25100004 )
2014
17
T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: Metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities. ( 25238936 )
2014
18
Lack of common TCRA and TCRB clonotypes in CD8(+)/TCRI+I^(+) T-cell large granular lymphocyte leukemia: a review on the role of antigenic selection in the immunopathogenesis of CD8(+) T-LGL. ( 24413066 )
2014
19
Submicroscopic genomic rearrangements change gene expression in T-cell large granular lymphocyte leukemia. ( 24649974 )
2014
20
Unusual concurrence of T-cell large granular lymphocytic leukemia with Franklin disease (gamma heavy chain disease) manifested with massive splenomegaly. ( 22694793 )
2013
21
CD4(-)/CD8(-) variant of T-cell large granular lymphocytic leukemia or hepatosplenic T-cell lymphoma: a clinicopathologic dilemma. ( 23800602 )
2013
22
Treatment of T-cell large granular lymphocyte leukemia with cyclosporine A: experience in a Chinese single institution. ( 23395383 )
2013
23
STAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia. ( 24283217 )
2013
24
Long-term remission of T-cell large granular lymphocyte leukemia associated with rheumatoid arthritis after rituximab therapy. ( 23869084 )
2013
25
T-cell large granular lymphocyte leukemia in a child with anemia and Crohn's disease. ( 23409990 )
2013
26
STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia. ( 23563237 )
2013
27
STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. ( 22859607 )
2012
28
Asymptomatic T-cell large granular lymphocyte leukemia with an unusual immunophenotype. ( 24765467 )
2012
29
Lymphocytosis: T-cell large granular lymphocyte leukemia. ( 23082329 )
2012
30
Increased serum soluble IL-15RI+ levels in T-cell large granular lymphocyte leukemia. ( 22049515 )
2012
31
Differential diagnosis of CD4-/CD8- I^I' T-cell large granular lymphocytic leukemia and hepatosplenic T-cell lymphoma. ( 22338065 )
2012
32
A case report: Concurrent chronic myelomonocytic leukemia and T-cell large granular lymphocytic leukemia-type clonal proliferation as detected by multiparametric flow cytometry. ( 21337493 )
2011
33
Bone marrow failure due to T-cell large granular lymphocytic leukemia in a patient with essential thrombocythemia. ( 20934219 )
2011
34
A case of concomitant T-cell large granular lymphocyte leukemia and plasma cell myeloma. ( 22252668 )
2011
35
Imatinib mesylate in T-cell large granular lymphocyte leukemia associated with chronic graft-versus-host disease. ( 21663506 )
2011
36
Lessons learned from an unusual presentation of CD3+, CD56- T-cell large granular lymphocyte leukemia. ( 20679608 )
2010
37
T-cell large granular lymphocyte leukemia: an Asian perspective. ( 20084380 )
2010
38
MICA polymorphism identified by whole genome array associated with NKG2D-mediated cytotoxicity in T-cell large granular lymphocyte leukemia. ( 20460636 )
2010
39
CD20dim-positive T-cell large granular lymphocytic leukemia in a patient with concurrent hairy cell leukemia and plasma cell myeloma. ( 21151394 )
2010
40
Rapid and durable molecular response of refractory T-cell large granular lymphocyte leukemia after alemtuzumab treatment. ( 20211489 )
2010
41
Long-term safety and efficacy of cyclosporin A therapy for T-cell large granular lymphocyte leukemia. ( 20038217 )
2010
42
A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia. ( 19660811 )
2010
43
CD20-positive T-cell large granular lymphocyte leukemia: case report and review of the literature. ( 19687595 )
2009
44
T cell large granular lymphocyte leukemia associated with rheumatoid arthritis and neutropenia. ( 19394280 )
2009
45
T-cell large granular lymphocyte leukemia presenting as end-stage renal disease: the diagnostic role of flow-cytometric and clonality analysis of the urine sediment. ( 19203516 )
2009
46
Protein-losing enteropathy due to T-cell large granular lymphocyte leukemia. ( 19307498 )
2009
47
T-cell large granular lymphocyte leukemia associated with myelodysplastic syndrome: a clinicopathologic study of nine cases. ( 19228641 )
2009
48
Outcomes of splenectomy in T-cell large granular lymphocyte leukemia with splenomegaly and cytopenia. ( 18550263 )
2008
49
The gammadelta variant of T cell large granular lymphocyte leukemia is very similar to the common alphabeta type: report of two cases. ( 19669213 )
2008
50
T-cell large granular lymphocyte leukemia: a cause of complex aphthosis not to be missed. ( 17637384 )
2007

Variations for T-Cell Large Granular Lymphocyte Leukemia

Expression for T-Cell Large Granular Lymphocyte Leukemia

Search GEO for disease gene expression data for T-Cell Large Granular Lymphocyte Leukemia.

Pathways for T-Cell Large Granular Lymphocyte Leukemia

Pathways related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 FASLG IL18 IL2 MICA NCAM1 STAT3
2
Show member pathways
13.18 FASLG IL18 IL2 STAT3 STAT5B
3
Show member pathways
13.06 FASLG IL18 IL2 NCAM1 STAT3 STAT5B
4
Show member pathways
12.64 FASLG GZMB IL2 MICA
5 12.63 FASLG IL2 STAT3 STAT5B
6
Show member pathways
12.49 FASLG IL18 IL2 STAT3 STAT5B
7
Show member pathways
12.39 IL18 IL2 STAT3 STAT5B
8
Show member pathways
12.37 IL18 IL2 STAT3 STAT5B
9
Show member pathways
12.33 FASLG MICA STAT3 STAT5B
10
Show member pathways
12.31 FASLG GZMB STAT3
11
Show member pathways
12.27 FASLG GZMB IL2 MICA
12
Show member pathways
12.2 FASLG STAT3 STAT5B
13
Show member pathways
12.17 IL2 STAT3 STAT5B
14
Show member pathways
12.03 FASLG STAT3 STAT5B
15 11.95 FASLG GZMB IL2 NCAM1 STAT3 STAT5B
16 11.92 NCAM1 STAT3 STAT5B
17
Show member pathways
11.87 IL2 STAT3 STAT5B
18 11.79 FASLG IL18 STAT3
19 11.66 IL2 STAT3 STAT5B
20
Show member pathways
11.66 GZMB STAT3 STAT5B
21
Show member pathways
11.57 IL18 IL2 STAT3 STAT5B
22
Show member pathways
11.46 FASLG IL2 STAT5B
23 11.39 FASLG STAT3
24 11.39 FASLG IL2
25
Show member pathways
11.39 FASLG GZMB IL2
26 11.38 STAT3 STAT5B
27 11.37 IL18 STAT3
28 11.36 GZMB IL18 IL2 NCAM1
29 11.34 NCAM1 STAT5B
30
Show member pathways
11.31 STAT3 STAT5B
31
Show member pathways
11.29 STAT3 STAT5B
32
Show member pathways
11.27 STAT3 STAT5B
33 11.26 STAT3 STAT5B
34
Show member pathways
11.24 STAT3 STAT5B
35 11.18 FASLG IL18
36
Show member pathways
11.1 FASLG GZMB IL2
37
Show member pathways
11.07 FASLG GZMB IL18 IL2 STAT3
38 11.03 STAT3 STAT5B
39 11.03 FASLG IL18 IL2
40 10.94 IL18 IL2 STAT3
41 10.87 STAT3 STAT5B

GO Terms for T-Cell Large Granular Lymphocyte Leukemia

Biological processes related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.78 FASLG IL2 STAT3 STAT5B
2 cell-cell signaling GO:0007267 9.77 FASLG IL18 IL2
3 MAPK cascade GO:0000165 9.74 IL18 IL2 NCAM1
4 cellular response to hormone stimulus GO:0032870 9.59 STAT3 STAT5B
5 regulation of cell adhesion GO:0030155 9.58 IL18 STAT5B
6 positive regulation of interferon-gamma production GO:0032729 9.58 IL18 IL2
7 interleukin-7-mediated signaling pathway GO:0038111 9.56 STAT3 STAT5B
8 positive regulation of erythrocyte differentiation GO:0045648 9.55 STAT3 STAT5B
9 JAK-STAT cascade GO:0007259 9.54 STAT3 STAT5B
10 regulation of multicellular organism growth GO:0040014 9.52 STAT3 STAT5B
11 cytolysis GO:0019835 9.51 GZMB MICA
12 natural killer cell activation GO:0030101 9.49 IL18 IL2
13 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.46 STAT3 STAT5B
14 positive regulation of interleukin-17 production GO:0032740 9.43 IL18 IL2
15 positive regulation of inflammatory response GO:0050729 9.43 IL18 IL2 STAT5B
16 interleukin-15-mediated signaling pathway GO:0035723 9.4 STAT3 STAT5B
17 positive regulation of natural killer cell proliferation GO:0032819 9.37 IL18 STAT5B
18 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.33 IL18 IL2 STAT3
19 positive regulation of tissue remodeling GO:0034105 9.32 IL18 IL2
20 positive regulation of activated T cell proliferation GO:0042104 9.13 IL18 IL2 STAT5B
21 natural killer cell mediated cytotoxicity GO:0042267 8.8 GZMB IL18 MICA

Molecular functions related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 FASLG IL18 IL2
2 glucocorticoid receptor binding GO:0035259 8.62 STAT3 STAT5B

Sources for T-Cell Large Granular Lymphocyte Leukemia

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