T-LGL
MCID: TCL002
MIFTS: 48

T-Cell Large Granular Lymphocyte Leukemia (T-LGL) malady

Blood diseases, Cancer diseases, Rare diseases, Immune diseases categories
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Summaries for T-Cell Large Granular Lymphocyte Leukemia

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Disease Ontology:8 A chronic lymphocytic leukemia that exhibits an unexplained, chronic (> 6 months) elevation in large granular lymphocytes (lgls) in the peripheral blood.

MalaCards based summary: T-Cell Large Granular Lymphocyte Leukemia, also known as proliferation of large granular lymphocytes, is related to leukemia and myeloma. An important gene associated with T-Cell Large Granular Lymphocyte Leukemia is KIR2DL1 (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1), and among its related pathways are IL12 signaling mediated by STAT4 and IL2-mediated signaling events. The compounds tuberculin and cuprophan have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and bone, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:65 Large granular lymphocytic leukemia is a disease that exhibits an unexplained, chronic (> 6 months)... more...

Aliases & Classifications for T-Cell Large Granular Lymphocyte Leukemia

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Sources:
8Disease Ontology, 44Novoseek, 48Orphanet, 62UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

T-Cell Large Granular Lymphocyte Leukemia, Aliases & Descriptions:

Name: T-Cell Large Granular Lymphocyte Leukemia 8 48 62
Proliferation of Large Granular Lymphocytes 48
Leukemia, Large Granular Lymphocytic 62
Leukemia Lymphocytic Large Granular 44
Large Granular Lymphocytic Leukemia 8
 
Lown-Ganong-Levine Syndrome 62
T-Cell Lgl Leukemia 48
T Cell Lgl Leukemia 62
T-Lgl 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48

External Ids:

Disease Ontology8 DOID:0050751
MESH via Orphanet35 D054066
ICD10 via Orphanet26 C91.5
UMLS via Orphanet63 C1955861

Related Diseases for T-Cell Large Granular Lymphocyte Leukemia

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Diseases related to T-Cell Large Granular Lymphocyte Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.3LBR, STAT3, KLRK1, IL2RA
2myeloma31.1KLRK1, STAT3
3t-cell leukemia30.6IL2RA, STAT3, LBR
4anaplastic large cell lymphoma30.6IL2RA, STAT3
5celiac disease30.5KLRK1, MICA
6rheumatoid arthritis30.2KLRK1, KIR2DL1, LBR, KLRD1, IL2RA
7systemic lupus erythematosus30.2IL2RA, KLRD1, KLRK1, LBR
8multiple sclerosis30.2KLRK1, IL2RA, LBR
9large granular lymphocyte leukemia11.3
10natural killer cell leukemia10.6
11arthritis10.6
12myelodysplastic syndromes10.6
13neutropenia10.6
14prolymphocytic leukemia10.6
15splenomegaly10.6
16t-cell prolymphocytic leukemia10.6
17hepatosplenic t-cell lymphoma10.6
18hepatitis10.4
19autoimmune hemolytic anemia10.4
20purpura10.4
21chronic active epstein-barr virus infection10.4
22chronic myelomonocytic leukemia10.4
23crohn's disease10.4
24graft versus host disease10.4
25hemolytic anemia10.4
26pure red-cell aplasia10.4
27sjogren's syndrome10.4
28gamma heavy chain disease10.4
29protein-losing enteropathy10.4
30hairy cell leukemia10.4
31heavy chain disease10.4
32lupus erythematosus10.4
33neuropathy10.4
34chronic graft versus host disease10.4
35essential thrombocythemia10.4
36human t-cell leukemia virus type 110.4
37aplastic anemia10.3
38autoimmune hepatitis10.3
39b-cell lymphomas10.3
40chronic lymphocytic leukemia10.3
41common variable immunodeficiency10.3
42granuloma annulare10.3
43hematopoietic stem cell transplantation10.3
44hepatocellular carcinoma10.3
45lymphomatoid granulomatosis10.3
46myelofibrosis10.3
47thrombocytopenia10.3
48ulcerative colitis10.3
49hepatitis c10.3
50lambert-eaton myasthenic syndrome10.3

Graphical network of the top 20 diseases related to T-Cell Large Granular Lymphocyte Leukemia:



Diseases related to t-cell large granular lymphocyte leukemia

Symptoms for T-Cell Large Granular Lymphocyte Leukemia

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Drugs & Therapeutics for T-Cell Large Granular Lymphocyte Leukemia

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Drug clinical trials:

Search ClinicalTrials for T-Cell Large Granular Lymphocyte Leukemia

Search NIH Clinical Center for T-Cell Large Granular Lymphocyte Leukemia

Genetic Tests for T-Cell Large Granular Lymphocyte Leukemia

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Anatomical Context for T-Cell Large Granular Lymphocyte Leukemia

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MalaCards organs/tissues related to T-Cell Large Granular Lymphocyte Leukemia:

32
T cells, Bone marrow, Bone, Nk cells, Spleen, B cells

Animal Models for T-Cell Large Granular Lymphocyte Leukemia or affiliated genes

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MGI Mouse Phenotypes related to T-Cell Large Granular Lymphocyte Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.3KLRK1, IL15RA, IL2RA, STAT3, LBR
2MP:00053877.1KLRD1, LBR, STAT3, IL2RA, IL15RA, KLRK1

Publications for T-Cell Large Granular Lymphocyte Leukemia

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Articles related to T-Cell Large Granular Lymphocyte Leukemia:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
Lack of common TCRA and TCRB clonotypes in CD8(+)/TCRI+I^(+) T-cell large granular lymphocyte leukemia: a review on the role of antigenic selection in the immunopathogenesis of CD8(+) T-LGL. (24413066)
2014
2
T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: Metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities. (25238936)
2014
3
Acquired inhibitors to factor VIII and fibrinogen in the setting of T-cell large granular lymphocyte leukemia: a case report and review of the literature. (25396761)
2014
4
Concurrent administration of darbepoetin alfa, cyclosporine A, and prednisolone is useful for T cell large granular lymphocyte leukemia associated with myelodysplastic syndrome complicated by Coombs-negative hemolytic anemia. (24756696)
2014
5
Coexistence of ALK-anaplastic large cell lymphoma and CD4+ T cell large granular lymphocytic leukemia. (25100004)
2014
6
T-Cell Large Granular Lymphocyte Leukemia in the Lower Eyelid. (25198396)
2014
7
Submicroscopic genomic rearrangements change gene expression in T-cell large granular lymphocyte leukemia. (24649974)
2014
8
STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia. (23563237)
2013
9
Treatment of T-cell large granular lymphocyte leukemia with cyclosporine A: experience in a Chinese single institution. (23395383)
2013
10
T-cell large granular lymphocyte leukemia in a child with anemia and Crohn's disease. (23409990)
2013
11
Long-term remission of T-cell large granular lymphocyte leukemia associated with rheumatoid arthritis after rituximab therapy. (23869084)
2013
12
STAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia. (24283217)
2013
13
Asymptomatic T-cell large granular lymphocyte leukemia with an unusual immunophenotype. (24765467)
2012
14
Lymphocytosis: T-cell large granular lymphocyte leukemia. (23082329)
2012
15
Differential diagnosis of CD4-/CD8- I^I' T-cell large granular lymphocytic leukemia and hepatosplenic T-cell lymphoma. (22338065)
2012
16
Increased serum soluble IL-15RI+ levels in T-cell large granular lymphocyte leukemia. (22049515)
2012
17
Bone marrow failure due to T-cell large granular lymphocytic leukemia in a patient with essential thrombocythemia. (20934219)
2011
18
A case report: Concurrent chronic myelomonocytic leukemia and T-cell large granular lymphocytic leukemia-type clonal proliferation as detected by multiparametric flow cytometry. (21337493)
2011
19
Imatinib mesylate in T-cell large granular lymphocyte leukemia associated with chronic graft-versus-host disease. (21663506)
2011
20
Long-term safety and efficacy of cyclosporin A therapy for T-cell large granular lymphocyte leukemia. (20038217)
2010
21
A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia. (19660811)
2010
22
CD20dim-positive T-cell large granular lymphocytic leukemia in a patient with concurrent hairy cell leukemia and plasma cell myeloma. (21151394)
2010
23
Lessons learned from an unusual presentation of CD3+, CD56- T-cell large granular lymphocyte leukemia. (20679608)
2010
24
MICA polymorphism identified by whole genome array associated with NKG2D-mediated cytotoxicity in T-cell large granular lymphocyte leukemia. (20460636)
2010
25
T-cell large granular lymphocyte leukemia associated with myelodysplastic syndrome: a clinicopathologic study of nine cases. (19228641)
2009
26
T cell large granular lymphocyte leukemia associated with rheumatoid arthritis and neutropenia. (19394280)
2009
27
T-cell large granular lymphocyte leukemia presenting as end-stage renal disease: the diagnostic role of flow-cytometric and clonality analysis of the urine sediment. (19203516)
2009
28
CD20-positive T-cell large granular lymphocyte leukemia: case report and review of the literature. (19687595)
2009
29
The gammadelta variant of T cell large granular lymphocyte leukemia is very similar to the common alphabeta type: report of two cases. (19669213)
2008
30
Outcomes of splenectomy in T-cell large granular lymphocyte leukemia with splenomegaly and cytopenia. (18550263)
2008
31
Malignant transformation of T-cell large granular lymphocyte leukemia in a dog. (17611371)
2007
32
Aggressive T-cell large granular lymphocyte leukemia: a case report and review of the literature. (17205534)
2007
33
CD20- and CD56-positive T-cell large granular lymphocyte leukemia in a human T-cell leukemia virus type 1 carrier. (18055343)
2007
34
T-cell large granular lymphocyte leukemia of donor origin after cord blood transplantation. (17875238)
2007
35
Characterization of T-cell large granular lymphocyte leukemia associated with Sjogren's syndrome-an important but under-recognized association. (16616153)
2006
36
Histopathology of the spleen in T-cell large granular lymphocyte leukemia and T-cell prolymphocytic leukemia: a comparative review. (15958859)
2005
37
T-cell large granular lymphocyte leukemias have multiple phenotypic abnormalities involving pan-T-cell antigens and receptors for MHC molecules. (16416744)
2005
38
T-cell large granular lymphocytic leukemia of donor origin occurring after allogeneic bone marrow transplantation for B-cell lymphoproliferative disorders. (15842042)
2005
39
CD52 expression in T-cell large granular lymphocyte leukemia--implications for treatment with alemtuzumab. (16019510)
2005
40
Reversible paraneoplastic neuropathy associated with T-cell large granular lymphocyte leukemia. (15304606)
2004
41
T-cell large granular lymphocyte leukemia and related disorders. (15169980)
2004
42
Differential gene-expression profiling in the leukemia cell lines derived from indolent and aggressive phases of CD56+ T-cell large granular lymphocyte leukemia. (14712486)
2004
43
Increased serum interleukin-18 in a patient with systemic lupus erythematosus and T-cell large granular lymphocytic leukemia. (17143689)
2004
44
T-cell large granular lymphocyte leukemia of donor origin after allogeneic bone marrow transplantation. (14560574)
2003
45
Deletion 6q as a recurrent chromosomal aberration in T-cell large granular lymphocyte leukemia. (12547164)
2002
46
Pathologic quiz case: chronic anemia with red cell aplasia and lymphocytosis in a middle-aged man. T-cell large granular lymphocyte leukemia. (12503585)
2002
47
SjAPgren's syndrome associated T cell large granular lymphocyte leukemia: a possible common etiopathogenesis. (12180753)
2002
48
New t(11;12)(q12;q11) characterized by RxFISH in a patient with T-cell large granular lymphocyte leukemia. (11297771)
2001
49
Humoral immune abnormalities in T-cell large granular lymphocyte leukemia. (9031118)
1996
50
Aggressive acute CD3+, CD56- T cell large granular lymphocyte leukemia with two stages of maturation arrest. (8751472)
1996

Variations for T-Cell Large Granular Lymphocyte Leukemia

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Expression for genes affiliated with T-Cell Large Granular Lymphocyte Leukemia

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Expression patterns in normal tissues for genes affiliated with T-Cell Large Granular Lymphocyte Leukemia

Search GEO for disease gene expression data for T-Cell Large Granular Lymphocyte Leukemia.

Pathways for genes affiliated with T-Cell Large Granular Lymphocyte Leukemia

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Pathways related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL2RA, STAT3
2
Show member pathways
IL-2 Signaling pathway37
9.5IL2RA, STAT3
39.5IL2RA, STAT3
4
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.5IL2RA, STAT3
59.5IL2RA, STAT3
6
Show member pathways
9.5IL2RA, IL15RA
7
Show member pathways
Type III interferon signaling37
9.0STAT3, IL2RA, IL15RA
8
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.0IL15RA, IL2RA, STAT3
98.7KLRD1, KLRK1, KIR2DL1, KIR2DL3
10
Show member pathways
8.7KIR2DL3, KIR2DL1, KLRK1, KLRD1
11
Show member pathways
Immune response CD16 signaling in NK cells60
8.3MICA, KIR2DL3, KIR2DL1, KLRK1, KLRD1
12
Show member pathways
8.2STAT3, KIR2DL3, KIR2DL1, KLRK1, KLRD1
13
Show member pathways
7.6KLRD1, KIR2DL1, KIR2DL3, IL15RA, IL2RA, MICA

Compounds for genes affiliated with T-Cell Large Granular Lymphocyte Leukemia

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Compounds related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1tuberculin4410.0IL2RA, LBR
2cuprophan4410.0LBR, IL2RA
3phorbol 12,13-dibutyrate4410.0IL2RA, LBR
4okt34410.0IL2RA, LBR
5con a4410.0LBR, IL2RA
6diethyl dithiocarbamate4410.0IL2RA, LBR
7sodium arsenite449.9LBR, IL2RA
8ouabain44 1110.9IL2RA, LBR
9polyinosinic-polycytidylic acid449.9KLRK1, STAT3
10infliximab44 50 1111.9IL2RA, LBR
11as 10144 6110.9IL2RA, STAT3
12pentoxifylline44 1110.8LBR, IL2RA
13ribavirin44 50 1111.8STAT3, LBR
14neopterin449.8LBR, IL2RA
15malondialdehyde449.7LBR, IL2RA
16ifn-alpha449.6IL2RA, STAT3
17cadmium44 2410.5LBR, STAT3, IL2RA
18rituximab44 50 1111.5IL2RA, STAT3
19vitamin-e449.5IL2RA, STAT3, LBR
20mifepristone44 28 61 1112.5LBR, STAT3, IL2RA
21rantes449.5IL2RA, STAT3, LBR
22rapamycin449.4IL2RA, STAT3, LBR
23genistein44 28 61 2 24 1114.4LBR, STAT3, IL2RA
24cyclosporin a44 28 6111.3IL2RA, STAT3, LBR
25heparin44 28 24 1112.1IL2RA, STAT3, LBR
26thymidine44 2410.0LBR, STAT3, IL2RA
27cisplatin44 50 61 1111.8IL2RA, STAT3, LBR
28arginine448.5GZMK, KLRK1, IL2RA, STAT3, LBR
29tyrosine448.1LBR, STAT3, IL2RA, KIR2DL3, KIR2DL1, KLRD1

GO Terms for genes affiliated with T-Cell Large Granular Lymphocyte Leukemia

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Cellular components related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.5KLRD1, KIR2DL1, KIR2DL3, IL15RA, IL2RA, STAT3

Biological processes related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1JAK-STAT cascadeGO:0072599.3IL15RA, STAT3
2immune responseGO:0069559.1IL2RA, KIR2DL3, KIR2DL1
3regulation of immune responseGO:0507769.0KLRD1, KIR2DL1, KIR2DL3
4cell proliferationGO:0082839.0IL15RA, IL2RA, STAT3

Molecular functions related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antigen bindingGO:0038239.7KIR2DL3, MICA

Products for genes affiliated with T-Cell Large Granular Lymphocyte Leukemia

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Sources for T-Cell Large Granular Lymphocyte Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet