MCID: TCL002
MIFTS: 42

T-Cell Large Granular Lymphocyte Leukemia malady

Categories: Cancer diseases, Immune diseases, Blood diseases

Aliases & Classifications for T-Cell Large Granular Lymphocyte Leukemia

Aliases & Descriptions for T-Cell Large Granular Lymphocyte Leukemia:

Name: T-Cell Large Granular Lymphocyte Leukemia 12 14 69
Leukemia, Large Granular Lymphocytic 69
Large Granular Lymphocytic Leukemia 12
Leukemia Lymphocytic Large Granular 52

Classifications:



External Ids:

Disease Ontology 12 DOID:0050751

Summaries for T-Cell Large Granular Lymphocyte Leukemia

Disease Ontology : 12 A chronic lymphocytic leukemia that exhibits an unexplained, chronic (> 6 months) elevation in large granular lymphocytes (LGLs) in the peripheral blood.

MalaCards based summary : T-Cell Large Granular Lymphocyte Leukemia, also known as leukemia, large granular lymphocytic, is related to large granular lymphocyte leukemia and leukemia. An important gene associated with T-Cell Large Granular Lymphocyte Leukemia is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Cefepime and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow, and related phenotype is vision/eye.

Wikipedia : 71 Large granular lymphocytic (LGL) leukemia is a chronic lymphoproliferative disorder that exhibits an... more...

Related Diseases for T-Cell Large Granular Lymphocyte Leukemia

Diseases related to T-Cell Large Granular Lymphocyte Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
id Related Disease Score Top Affiliating Genes
1 large granular lymphocyte leukemia 11.9
2 leukemia 10.9
3 lymphoma 10.3
4 hepatosplenic t-cell lymphoma 10.2
5 pure red-cell aplasia 10.2
6 psoriatic arthritis 10.1 IL18 MICA
7 splenomegaly 10.1
8 t-cell prolymphocytic leukemia 10.1
9 heavy chain disease 10.1
10 gamma heavy chain disease 10.1
11 rheumatoid arthritis 10.1
12 prolymphocytic leukemia 10.1
13 myelodysplastic syndrome 10.1
14 arthritis 10.1
15 t-cell leukemia 10.1
16 neutropenia 10.1
17 histiocytic and dendritic cell cancer 10.1 FASLG GZMB
18 skeletal muscle cancer 10.1 FASLG GZMB
19 alström syndrome 10.0 GZMB NCAM1
20 macrogyria, pseudobulbar palsy and mental retardation 10.0 FASLG GZMB
21 superior limbic keratoconjunctivitis 10.0 GZMB NCAM1
22 malignant teratoma 10.0 FASLG GZMB
23 active peptic ulcer disease 10.0 FASLG NCAM1
24 benign eccrine breast spiradenoma 10.0 FASLG IL18 STAT3
25 cerebral sarcoidosis 10.0 IL2 STAT3
26 cutis laxa, autosomal recessive, type ib 10.0 MICA NCAM1 STAT3
27 inflammatory bowel disease 3 9.9 GZMB KLRK1 MICA
28 lateral body wall defect 9.9 KIR2DL3 KLRK1 MICA STAT3
29 laryngotracheoesophageal cleft type 2 9.9 IL18 IL2
30 good syndrome 9.9
31 systemic lupus erythematosus 9.9
32 protein-losing enteropathy 9.9
33 sjogren's syndrome 9.9
34 anaplastic large cell lymphoma 9.9
35 essential thrombocythemia 9.9
36 chronic myelomonocytic leukemia 9.9
37 hairy cell leukemia 9.9
38 crohn's disease 9.9
39 hematopoietic stem cell transplantation 9.9
40 neuropathy 9.9
41 hemolytic anemia 9.9
42 lupus erythematosus 9.9
43 chronic graft versus host disease 9.9
44 human t-cell leukemia virus type 1 9.9
45 peripheral t-cell lymphoma 9.9
46 red cell phospholipid defect with hemolysis 9.9 GZMB IL18
47 hepatitis 9.9 IL2 KIR2DL3
48 stomatitis 9.9 IL18 IL2
49 mixed cell type cancer 9.9 FASLG GZMB NCAM1
50 joubert syndrome 18 9.9 FASLG IL2 STAT3

Graphical network of the top 20 diseases related to T-Cell Large Granular Lymphocyte Leukemia:



Diseases related to T-Cell Large Granular Lymphocyte Leukemia

Symptoms & Phenotypes for T-Cell Large Granular Lymphocyte Leukemia

MGI Mouse Phenotypes related to T-Cell Large Granular Lymphocyte Leukemia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.02 FASLG IL18 IL2 NCAM1 STAT3

Drugs & Therapeutics for T-Cell Large Granular Lymphocyte Leukemia

Drugs for T-Cell Large Granular Lymphocyte Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 239)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefepime Approved Phase 3 88040-23-7 5479537
2
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
3
Ofloxacin Approved Phase 3 82419-36-1 4583
4
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
5
Carboplatin Approved Phase 2, Phase 3,Phase 1 41575-94-4 10339178 498142 38904
6
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
7
Darbepoetin alfa Approved, Investigational Phase 3,Phase 2 11096-26-7, 209810-58-2
8
Iron Approved Phase 3,Phase 1,Phase 2 7439-89-6 23925
9
Dextromethorphan Approved Phase 3 125-71-3 5360696 5362449
10
Guaifenesin Approved, Vet_approved Phase 3,Phase 2 93-14-1 3516
11
Morphine Approved, Investigational Phase 3 57-27-2 5288826
12
Dalteparin Approved Phase 3 9041-08-1
13
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
14
Ondansetron Approved Phase 3 99614-02-5 4595
15
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
16
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
17
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
18
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
19
Busulfan Approved, Investigational Phase 2, Phase 3,Phase 1,Early Phase 1 55-98-1 2478
20
Etoposide Approved Phase 2, Phase 3,Phase 1,Early Phase 1 33419-42-0 36462
21
Fludarabine Approved Phase 2, Phase 3, Phase 1 21679-14-1, 75607-67-9 30751
22
Thiotepa Approved Phase 2, Phase 3,Phase 1 52-24-4 5453
23
Melphalan Approved Phase 2, Phase 3 148-82-3 4053 460612
24
Ginseng Approved, Nutraceutical Phase 3 50647-08-0
25 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
26 Anti-Infective Agents Phase 3,Phase 2,Phase 1
27 Cephalosporins Phase 3
28 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
29 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 1,Phase 2
30 Renal Agents Phase 3,Phase 1,Phase 2
31 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
32 Analgesics Phase 3,Phase 2
33 Anesthetics Phase 3
34 Anesthetics, Dissociative Phase 3
35 Anesthetics, General Phase 3
36 Anesthetics, Intravenous Phase 3
37 Central Nervous System Depressants Phase 3,Phase 1,Phase 2
38 Excitatory Amino Acid Antagonists Phase 3
39 Excitatory Amino Acids Phase 3
40 Neurotransmitter Agents Phase 3,Phase 1
41 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
42 Alkylating Agents Phase 2, Phase 3,Phase 1,Early Phase 1
43 Antineoplastic Agents, Alkylating Phase 2, Phase 3,Phase 1,Early Phase 1
44 Antirheumatic Agents Phase 2, Phase 3,Phase 1,Early Phase 1
45 Immunosuppressive Agents Phase 2, Phase 3,Phase 1,Early Phase 1
46 Ferric Compounds Phase 3
47 ferric gluconate Phase 3
48 Hematinics Phase 3,Phase 2
49 Analgesics, Opioid Phase 3
50 Antitussive Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 125)
id Name Status NCT ID Phase
1 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3
2 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3
3 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3
4 Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Completed NCT00661999 Phase 3
5 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
6 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3
7 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
8 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3
9 Darbepoetin Alfa Compared With Epoetin Alfa in Treating Anemia in Patients Receiving Chemotherapy for Cancer Completed NCT00070382 Phase 3
10 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3
11 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
12 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3
13 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3
14 Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer Active, not recruiting NCT00003816 Phase 2, Phase 3
15 Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas Unknown status NCT01805037 Phase 1, Phase 2
16 Cyclosporine in Treating Patients With Low Blood Counts Caused By Hematologic Cancer Completed NCT00031980 Phase 2
17 506U78 in Treating Patients With Chronic Lymphocytic Leukemia That Has Not Responded to Fludarabine or Alkylating Agents Completed NCT00003635 Phase 2
18 Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Completed NCT01093586 Phase 2
19 Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma Completed NCT01258998 Phase 2
20 Combination Chemotherapy Followed By Alemtuzumab in Treating Patients With Chronic Lymphocytic Leukemia or Prolymphocytic Leukemia Completed NCT00278213 Phase 2
21 Peripheral Stem Cell Transplantation in Treating Patients With Breast Cancer or Hematologic Cancer Completed NCT00006225 Phase 1, Phase 2
22 Doxorubicin Hydrochloride Liposome and Bortezomib in Treating Patients With Refractory Hematologic Cancer or Malignant Solid Tumor or Metastatic Breast Cancer Completed NCT00237627 Phase 1, Phase 2
23 Epoetin Alfa in Treating Patients With Anemia Who Are Undergoing Chemotherapy for Cancer Completed NCT00255749 Phase 2
24 Epoetin Alfa or Darbepoetin Alfa in Treating Patients With Anemia Caused by Chemotherapy Completed NCT00416624 Phase 2
25 Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Refractory Cancer Completed NCT00003406 Phase 1, Phase 2
26 Donor Natural Killer Cells After Donor Stem Cell Transplant in Treating Patients With Advanced Cancer Completed NCT00823524 Phase 1, Phase 2
27 Interleukin-2 Plus Interferon Alfa in Treating Adults With Metastatic Cancer Completed NCT00002504 Phase 2
28 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00005804 Phase 2
29 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2
30 Prospective, Multicentric, Phase II Randomized Controlled Trial on Two Parallel Groups Comparing the Efficacy of Two Immunosuppressive Drugs (Methotrexate, Cyclophosphamide) in Large Granular Lymphocytes Leukemia Recruiting NCT01976182 Phase 2
31 Alemtuzumab (Campath ) to Treat T-Large Granular Lymphocyte Leukemia Recruiting NCT00345345 Phase 2
32 Dasatinib for Immune Modulation After Donor Stem Cell Transplant for Hematologic Malignancies Recruiting NCT01643603 Phase 1, Phase 2
33 CAR-pNK Cell Immunotherapy in CD7 Positive Leukemia and Lymphoma Recruiting NCT02742727 Phase 1, Phase 2
34 Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies Recruiting NCT01839916 Phase 2
35 A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies Recruiting NCT01384513 Phase 2
36 Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies Recruiting NCT01760655 Phase 2
37 Dasatinib for Modulating Immune System After Autologous Stem Cell Transplants for Multiple Myeloma, Non-Hodgkin, or Hodgkin Lymphoma Recruiting NCT01609816 Phase 1, Phase 2
38 Biological Therapy in Treating Patients at High-Risk or With Lymphoma, Lymphoproliferative Disease, or Malignancies Recruiting NCT00002663 Phase 1, Phase 2
39 Fludarabine Phosphate, Radiation Therapy, and Rituximab in Treating Patients Who Are Undergoing Donor Stem Cell Transplant Followed by Rituximab for High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Active, not recruiting NCT00104858 Phase 2
40 Alemtuzumab, Fludarabine Phosphate, and Low-Dose Total Body Irradiation Before Donor Stem Cell Transplantation in Treating Patients With Hematological Malignancies Active, not recruiting NCT00040846 Phase 2
41 Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancer Active, not recruiting NCT00006251 Phase 1, Phase 2
42 Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Active, not recruiting NCT01529827 Phase 2
43 Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant Active, not recruiting NCT00078858 Phase 1, Phase 2
44 Romidepsin Maintenance After Allogeneic Stem Cell Transplantation Active, not recruiting NCT02512497 Phase 1, Phase 2
45 Effect of Cyclosporine Therapy on Gene Expression in Patients With Large Granular Lymphocyte Leukemia Terminated NCT00363779 Phase 2
46 Methotrexate Followed by Fludarabine in Patients With T-Cell Large Granular Lymphocytic Leukemia Terminated NCT00278265 Phase 2
47 Alemtuzumab in Myelodysplastic Syndrome (MDS), Aplastic Anemia, and T-Cell Large Granular Lymphocytic Leukemia (T-GL) Terminated NCT01191749 Phase 2
48 Tipifarnib in Treating Patients With Anemia or Neutropenia and Large Granular Lymphocyte Leukemia Terminated NCT00360776 Phase 2
49 Methotrexate With or Without Cyclophosphamide in Treating Patients With Lymphocytic Leukemia Terminated NCT00003910 Phase 2
50 Lenalidomide With or Without Rituximab in Treating Patients With Progressive or Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Prolymphocytic Leukemia, or Non-Hodgkin Lymphoma Previously Treated With Donor Stem Cell Transplant Terminated NCT01419795 Phase 2

Search NIH Clinical Center for T-Cell Large Granular Lymphocyte Leukemia

Genetic Tests for T-Cell Large Granular Lymphocyte Leukemia

Anatomical Context for T-Cell Large Granular Lymphocyte Leukemia

MalaCards organs/tissues related to T-Cell Large Granular Lymphocyte Leukemia:

39
T Cells, Bone, Bone Marrow, Nk Cells, B Cells, Spleen

Publications for T-Cell Large Granular Lymphocyte Leukemia

Articles related to T-Cell Large Granular Lymphocyte Leukemia:

(show top 50) (show all 73)
id Title Authors Year
1
Distinguishing Between Hepatosplenic T-cell Lymphoma and I^I' T-cell Large Granular Lymphocytic Leukemia: A Clinicopathologic, Immunophenotypic, and Molecular Analysis. ( 27755009 )
2017
2
Gamma Heavy Chain Disease with T-cell Large Granular Lymphocytic Leukemia: A Case Report and Review of the Literature. ( 26875967 )
2016
3
High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia. ( 27697773 )
2016
4
Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia. ( 26199174 )
2016
5
Donor-Derived T-Cell Large Granular Lymphocytic Leukemia in a Patient With Peripheral T-Cell Lymphoma. ( 27496109 )
2016
6
Moderate-dose cyclophosphamide in the treatment of relapsed/refractory T-cell large granular lymphocytic leukemia-associated pure red cell aplasia. ( 27077768 )
2016
7
Hematopoietic stem cell transplantation for T-cell large granular lymphocyte leukemia: a retrospective study of the European Society for Blood and Marrow Transplantation. ( 26460210 )
2015
8
Good syndrome presenting with CD8+ T-Cell large granular lymphocyte leukemia. ( 26429871 )
2015
9
Lack of common TCRA and TCRB clonotypes in CD8(+)/TCRI+I^(+) T-cell large granular lymphocyte leukemia: a review on the role of antigenic selection in the immunopathogenesis of CD8(+) T-LGL. ( 24413066 )
2014
10
Submicroscopic genomic rearrangements change gene expression in T-cell large granular lymphocyte leukemia. ( 24649974 )
2014
11
Acquired inhibitors to factor VIII and fibrinogen in the setting of T-cell large granular lymphocyte leukemia: a case report and review of the literature. ( 25396761 )
2014
12
Concurrent administration of darbepoetin alfa, cyclosporine A, and prednisolone is useful for T cell large granular lymphocyte leukemia associated with myelodysplastic syndrome complicated by Coombs-negative hemolytic anemia. ( 24756696 )
2014
13
Coexistence of ALK-anaplastic large cell lymphoma and CD4+ T cell large granular lymphocytic leukemia. ( 25100004 )
2014
14
T-Cell Large Granular Lymphocyte Leukemia in the Lower Eyelid. ( 25198396 )
2014
15
T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: Metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities. ( 25238936 )
2014
16
Distinct effect of cyclophosphamide and cyclosporine on pure red cell aplasia associated with T-cell large granular lymphocyte leukemia. ( 25466263 )
2014
17
CD4(-)/CD8(-) variant of T-cell large granular lymphocytic leukemia or hepatosplenic T-cell lymphoma: a clinicopathologic dilemma. ( 23800602 )
2013
18
T-cell large granular lymphocyte leukemia in a child with anemia and Crohn's disease. ( 23409990 )
2013
19
Unusual concurrence of T-cell large granular lymphocytic leukemia with Franklin disease (gamma heavy chain disease) manifested with massive splenomegaly. ( 22694793 )
2013
20
STAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia. ( 24283217 )
2013
21
STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia. ( 23563237 )
2013
22
Long-term remission of T-cell large granular lymphocyte leukemia associated with rheumatoid arthritis after rituximab therapy. ( 23869084 )
2013
23
Treatment of T-cell large granular lymphocyte leukemia with cyclosporine A: experience in a Chinese single institution. ( 23395383 )
2013
24
Lymphocytosis: T-cell large granular lymphocyte leukemia. ( 23082329 )
2012
25
Differential diagnosis of CD4-/CD8- I^I' T-cell large granular lymphocytic leukemia and hepatosplenic T-cell lymphoma. ( 22338065 )
2012
26
STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. ( 22859607 )
2012
27
Asymptomatic T-cell large granular lymphocyte leukemia with an unusual immunophenotype. ( 24765467 )
2012
28
Increased serum soluble IL-15RI+ levels in T-cell large granular lymphocyte leukemia. ( 22049515 )
2012
29
Bone marrow failure due to T-cell large granular lymphocytic leukemia in a patient with essential thrombocythemia. ( 20934219 )
2011
30
Imatinib mesylate in T-cell large granular lymphocyte leukemia associated with chronic graft-versus-host disease. ( 21663506 )
2011
31
A case report: Concurrent chronic myelomonocytic leukemia and T-cell large granular lymphocytic leukemia-type clonal proliferation as detected by multiparametric flow cytometry. ( 21337493 )
2011
32
A case of concomitant T-cell large granular lymphocyte leukemia and plasma cell myeloma. ( 22252668 )
2011
33
Long-term safety and efficacy of cyclosporin A therapy for T-cell large granular lymphocyte leukemia. ( 20038217 )
2010
34
Lessons learned from an unusual presentation of CD3+, CD56- T-cell large granular lymphocyte leukemia. ( 20679608 )
2010
35
T-cell large granular lymphocyte leukemia: an Asian perspective. ( 20084380 )
2010
36
Rapid and durable molecular response of refractory T-cell large granular lymphocyte leukemia after alemtuzumab treatment. ( 20211489 )
2010
37
A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia. ( 19660811 )
2010
38
CD20dim-positive T-cell large granular lymphocytic leukemia in a patient with concurrent hairy cell leukemia and plasma cell myeloma. ( 21151394 )
2010
39
MICA polymorphism identified by whole genome array associated with NKG2D-mediated cytotoxicity in T-cell large granular lymphocyte leukemia. ( 20460636 )
2010
40
T cell large granular lymphocyte leukemia associated with rheumatoid arthritis and neutropenia. ( 19394280 )
2009
41
T-cell large granular lymphocyte leukemia associated with myelodysplastic syndrome: a clinicopathologic study of nine cases. ( 19228641 )
2009
42
T-cell large granular lymphocyte leukemia presenting as end-stage renal disease: the diagnostic role of flow-cytometric and clonality analysis of the urine sediment. ( 19203516 )
2009
43
CD20-positive T-cell large granular lymphocyte leukemia: case report and review of the literature. ( 19687595 )
2009
44
Protein-losing enteropathy due to T-cell large granular lymphocyte leukemia. ( 19307498 )
2009
45
The gammadelta variant of T cell large granular lymphocyte leukemia is very similar to the common alphabeta type: report of two cases. ( 19669213 )
2008
46
Outcomes of splenectomy in T-cell large granular lymphocyte leukemia with splenomegaly and cytopenia. ( 18550263 )
2008
47
T-cell large granular lymphocyte leukemia: a cause of complex aphthosis not to be missed. ( 17637384 )
2007
48
Aggressive T-cell large granular lymphocyte leukemia: a case report and review of the literature. ( 17205534 )
2007
49
Malignant transformation of T-cell large granular lymphocyte leukemia in a dog. ( 17611371 )
2007
50
Fludarabine, mitoxantrone and dexamethasone as first-line treatment for T-cell large granular lymphocyte leukemia. ( 17525720 )
2007

Variations for T-Cell Large Granular Lymphocyte Leukemia

Expression for T-Cell Large Granular Lymphocyte Leukemia

Search GEO for disease gene expression data for T-Cell Large Granular Lymphocyte Leukemia.

Pathways for T-Cell Large Granular Lymphocyte Leukemia

Pathways related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

(show all 22)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 FASLG IL18 IL2 KIR2DL3 KLRK1 MICA
2
Show member pathways
13.07 FASLG IL18 IL2 NCAM1 STAT3
3
Show member pathways
12.54 FASLG GZMB IL2 KIR2DL3 MICA
4
Show member pathways
12.53 FASLG IL18 IL2 STAT3
5
Show member pathways
12.21 FASLG GZMB STAT3
6 12.15 FASLG GZMB IL2 NCAM1 STAT3
7
Show member pathways
12.11 FASLG GZMB IL2 KIR2DL3 KLRK1 MICA
8 11.83 KIR2DL3 KLRK1 MICA
9 11.75 IL2 KLRK1 NCAM1
10 11.73 FASLG IL18 STAT3
11
Show member pathways
11.68 IL18 IL2 STAT3
12
Show member pathways
11.41 FASLG GZMB IL18 IL2 STAT3
13
Show member pathways
11.39 FASLG GZMB IL2
14 11.31 FASLG STAT3
15 11.31 FASLG IL2
16 11.28 IL18 STAT3
17 11.27 IL18 KLRK1
18
Show member pathways
11.15 FASLG GZMB IL2
19 11.11 FASLG IL18
20 10.95 FASLG IL18 IL2
21 10.94 IL18 IL2 STAT3
22 10.92 GZMB IL18 IL2 KLRK1 NCAM1

GO Terms for T-Cell Large Granular Lymphocyte Leukemia

Cellular components related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 FASLG KLRK1 NCAM1
2 cell surface GO:0009986 8.92 FASLG KLRK1 MICA NCAM1

Biological processes related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.7 FASLG IL18 IL2
2 MAPK cascade GO:0000165 9.67 IL18 IL2 NCAM1
3 immune response GO:0006955 9.67 FASLG IL18 IL2 KIR2DL3
4 regulation of immune response GO:0050776 9.63 KIR2DL3 KLRK1 MICA
5 positive regulation of inflammatory response GO:0050729 9.54 IL18 IL2
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.51 IL18 IL2
7 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 9.48 IL18 STAT3
8 positive regulation of activated T cell proliferation GO:0042104 9.43 IL18 IL2
9 cytolysis GO:0019835 9.4 GZMB MICA
10 natural killer cell mediated cytotoxicity GO:0042267 9.32 GZMB MICA
11 positive regulation of interleukin-17 production GO:0032740 9.26 IL18 IL2
12 positive regulation of tissue remodeling GO:0034105 9.16 IL18 IL2
13 positive regulation of interferon-gamma production GO:0032729 9.13 IL18 IL2 KLRK1
14 natural killer cell activation GO:0030101 8.8 IL18 IL2 KLRK1

Molecular functions related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 FASLG IL18 IL2

Sources for T-Cell Large Granular Lymphocyte Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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