MCID: TCL002
MIFTS: 36

T-Cell Large Granular Lymphocyte Leukemia malady

Immune diseases category

Summaries for T-Cell Large Granular Lymphocyte Leukemia

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Disease Ontology:9 A chronic lymphocytic leukemia that exhibits an unexplained, chronic (> 6 months) elevation in large granular lymphocytes (lgls) in the peripheral blood.

MalaCards based summary: T-Cell Large Granular Lymphocyte Leukemia, also known as leukemia, large granular lymphocytic, is related to leukemia and myeloma. An important gene associated with T-Cell Large Granular Lymphocyte Leukemia is KIR2DL1 (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1), and among its related pathways are Immune response IL 12 signaling pathway and IL12 signaling mediated by STAT4. The compounds tuberculin and cuprophan have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and bone, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:63 Large granular lymphocytic leukemia is a disease that exhibits an unexplained, chronic (> 6 months)... more...

Aliases & Classifications for T-Cell Large Granular Lymphocyte Leukemia

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Sources:
9Disease Ontology, 60UMLS, 43Novoseek
See all sources

T-Cell Large Granular Lymphocyte Leukemia, Aliases & Descriptions:

Name: T-Cell Large Granular Lymphocyte Leukemia 9 60
Leukemia, Large Granular Lymphocytic 60
 
Leukemia Lymphocytic Large Granular 43
Large Granular Lymphocytic Leukemia 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


External Ids:

Disease Ontology9 DOID:0050751

Related Diseases for T-Cell Large Granular Lymphocyte Leukemia

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Diseases related to T-Cell Large Granular Lymphocyte Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.3LBR, STAT3, IL2RA, KLRK1
2myeloma31.1KLRK1, STAT3
3t-cell leukemia30.6IL2RA, STAT3, LBR
4celiac disease30.5KLRK1, MICA
5anaplastic large cell lymphoma30.5STAT3, IL2RA
6rheumatoid arthritis30.2LBR, IL2RA, KIR2DL1, KLRK1, KLRD1
7systemic lupus erythematosus30.2LBR, IL2RA, KLRK1, KLRD1
8large granular lymphocyte leukemia11.3
9natural killer cell leukemia10.6
10myelodysplastic syndrome10.6
11arthritis10.6
12neutropenia10.6
13pure red-cell aplasia10.6
14prolymphocytic leukemia10.6
15splenomegaly10.6
16hepatosplenic t-cell lymphoma10.6
17hepatitis10.5
18autoimmune hemolytic anemia10.4
19purpura10.4
20chronic active epstein-barr virus infection10.4
21chronic myelomonocytic leukemia10.4
22crohn's disease10.4
23hemolytic anemia10.4
24gamma heavy chain disease10.4
25protein-losing enteropathy10.4
26sjogren's syndrome10.4
27heavy chain disease10.4
28lupus erythematosus10.4
29neuropathy10.4
30chronic graft versus host disease10.4
31essential thrombocythemia10.4
32human t-cell leukemia virus type 110.4
33hepatocellular carcinoma10.3
34hepatitis c virus10.3
35aplastic anemia10.3
36autoimmune hepatitis10.3
37b-cell lymphomas10.3
38chronic lymphocytic leukemia10.3
39common variable immunodeficiency10.3
40granuloma annulare10.3
41hematopoietic stem cell transplantation10.3
42lymphomatoid granulomatosis10.3
43myelofibrosis10.3
44thrombocytopenia10.3
45ulcerative colitis10.3
46hepatitis c10.3
47malignant histiocytosis10.3
48lambert-eaton myasthenic syndrome10.3
49felty's syndrome10.3
50candidiasis10.3

Graphical network of the top 20 diseases related to T-Cell Large Granular Lymphocyte Leukemia:



Diseases related to t-cell large granular lymphocyte leukemia

Symptoms for T-Cell Large Granular Lymphocyte Leukemia

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Drugs & Therapeutics for T-Cell Large Granular Lymphocyte Leukemia

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Drug clinical trials:

Search ClinicalTrials for T-Cell Large Granular Lymphocyte Leukemia

Search NIH Clinical Center for T-Cell Large Granular Lymphocyte Leukemia

Genetic Tests for T-Cell Large Granular Lymphocyte Leukemia

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Anatomical Context for T-Cell Large Granular Lymphocyte Leukemia

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MalaCards organs/tissues related to T-Cell Large Granular Lymphocyte Leukemia:

31
T cells, Bone marrow, Bone, Nk cells, Spleen, B cells

Animal Models for T-Cell Large Granular Lymphocyte Leukemia or affiliated genes

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MGI Mouse Phenotypes related to T-Cell Large Granular Lymphocyte Leukemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.3KLRK1, IL15RA, IL2RA, STAT3, LBR
2MP:00053877.1KLRD1, LBR, STAT3, IL2RA, IL15RA, KLRK1

Publications for T-Cell Large Granular Lymphocyte Leukemia

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Articles related to T-Cell Large Granular Lymphocyte Leukemia:

(show top 50)    (show all 65)
idTitleAuthorsYear
1
Lack of common TCRA and TCRB clonotypes in CD8(+)/TCRI+I^(+) T-cell large granular lymphocyte leukemia: a review on the role of antigenic selection in the immunopathogenesis of CD8(+) T-LGL. (24413066)
2014
2
T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: Metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities. (25238936)
2014
3
Acquired inhibitors to factor VIII and fibrinogen in the setting of T-cell large granular lymphocyte leukemia: a case report and review of the literature. (25396761)
2014
4
Concurrent administration of darbepoetin alfa, cyclosporine A, and prednisolone is useful for T cell large granular lymphocyte leukemia associated with myelodysplastic syndrome complicated by Coombs-negative hemolytic anemia. (24756696)
2014
5
Coexistence of ALK-anaplastic large cell lymphoma and CD4+ T cell large granular lymphocytic leukemia. (25100004)
2014
6
T-Cell Large Granular Lymphocyte Leukemia in the Lower Eyelid. (25198396)
2014
7
Distinct effect of cyclophosphamide and cyclosporine on pure red cell aplasia associated with T-cell large granular lymphocyte leukemia. (25466263)
2014
8
Submicroscopic genomic rearrangements change gene expression in T-cell large granular lymphocyte leukemia. (24649974)
2014
9
STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia. (23563237)
2013
10
Treatment of T-cell large granular lymphocyte leukemia with cyclosporine A: experience in a Chinese single institution. (23395383)
2013
11
T-cell large granular lymphocyte leukemia in a child with anemia and Crohn's disease. (23409990)
2013
12
Long-term remission of T-cell large granular lymphocyte leukemia associated with rheumatoid arthritis after rituximab therapy. (23869084)
2013
13
Asymptomatic T-cell large granular lymphocyte leukemia with an unusual immunophenotype. (24765467)
2012
14
Lymphocytosis: T-cell large granular lymphocyte leukemia. (23082329)
2012
15
Differential diagnosis of CD4-/CD8- I^I' T-cell large granular lymphocytic leukemia and hepatosplenic T-cell lymphoma. (22338065)
2012
16
Increased serum soluble IL-15RI+ levels in T-cell large granular lymphocyte leukemia. (22049515)
2012
17
Bone marrow failure due to T-cell large granular lymphocytic leukemia in a patient with essential thrombocythemia. (20934219)
2011
18
A case report: Concurrent chronic myelomonocytic leukemia and T-cell large granular lymphocytic leukemia-type clonal proliferation as detected by multiparametric flow cytometry. (21337493)
2011
19
Imatinib mesylate in T-cell large granular lymphocyte leukemia associated with chronic graft-versus-host disease. (21663506)
2011
20
Long-term safety and efficacy of cyclosporin A therapy for T-cell large granular lymphocyte leukemia. (20038217)
2010
21
A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia. (19660811)
2010
22
CD20dim-positive T-cell large granular lymphocytic leukemia in a patient with concurrent hairy cell leukemia and plasma cell myeloma. (21151394)
2010
23
Lessons learned from an unusual presentation of CD3+, CD56- T-cell large granular lymphocyte leukemia. (20679608)
2010
24
MICA polymorphism identified by whole genome array associated with NKG2D-mediated cytotoxicity in T-cell large granular lymphocyte leukemia. (20460636)
2010
25
T-cell large granular lymphocyte leukemia associated with myelodysplastic syndrome: a clinicopathologic study of nine cases. (19228641)
2009
26
T cell large granular lymphocyte leukemia associated with rheumatoid arthritis and neutropenia. (19394280)
2009
27
T-cell large granular lymphocyte leukemia presenting as end-stage renal disease: the diagnostic role of flow-cytometric and clonality analysis of the urine sediment. (19203516)
2009
28
CD20-positive T-cell large granular lymphocyte leukemia: case report and review of the literature. (19687595)
2009
29
The gammadelta variant of T cell large granular lymphocyte leukemia is very similar to the common alphabeta type: report of two cases. (19669213)
2008
30
Outcomes of splenectomy in T-cell large granular lymphocyte leukemia with splenomegaly and cytopenia. (18550263)
2008
31
Malignant transformation of T-cell large granular lymphocyte leukemia in a dog. (17611371)
2007
32
Aggressive T-cell large granular lymphocyte leukemia: a case report and review of the literature. (17205534)
2007
33
CD20- and CD56-positive T-cell large granular lymphocyte leukemia in a human T-cell leukemia virus type 1 carrier. (18055343)
2007
34
Characterization of T-cell large granular lymphocyte leukemia associated with Sjogren's syndrome-an important but under-recognized association. (16616153)
2006
35
Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia. (16387851)
2006
36
Histopathology of the spleen in T-cell large granular lymphocyte leukemia and T-cell prolymphocytic leukemia: a comparative review. (15958859)
2005
37
T-cell large granular lymphocyte leukemias have multiple phenotypic abnormalities involving pan-T-cell antigens and receptors for MHC molecules. (16416744)
2005
38
T-cell large granular lymphocytic leukemia of donor origin occurring after allogeneic bone marrow transplantation for B-cell lymphoproliferative disorders. (15842042)
2005
39
CD52 expression in T-cell large granular lymphocyte leukemia--implications for treatment with alemtuzumab. (16019510)
2005
40
Reversible paraneoplastic neuropathy associated with T-cell large granular lymphocyte leukemia. (15304606)
2004
41
T-cell large granular lymphocyte leukemia and related disorders. (15169980)
2004
42
Differential gene-expression profiling in the leukemia cell lines derived from indolent and aggressive phases of CD56+ T-cell large granular lymphocyte leukemia. (14712486)
2004
43
Increased serum interleukin-18 in a patient with systemic lupus erythematosus and T-cell large granular lymphocytic leukemia. (17143689)
2004
44
T-cell large granular lymphocyte leukemia of donor origin after allogeneic bone marrow transplantation. (14560574)
2003
45
Deletion 6q as a recurrent chromosomal aberration in T-cell large granular lymphocyte leukemia. (12547164)
2002
46
Pathologic quiz case: chronic anemia with red cell aplasia and lymphocytosis in a middle-aged man. T-cell large granular lymphocyte leukemia. (12503585)
2002
47
SjAPgren's syndrome associated T cell large granular lymphocyte leukemia: a possible common etiopathogenesis. (12180753)
2002
48
New t(11;12)(q12;q11) characterized by RxFISH in a patient with T-cell large granular lymphocyte leukemia. (11297771)
2001
49
Humoral immune abnormalities in T-cell large granular lymphocyte leukemia. (9031118)
1996
50
Aggressive acute CD3+, CD56- T cell large granular lymphocyte leukemia with two stages of maturation arrest. (8751472)
1996

Variations for T-Cell Large Granular Lymphocyte Leukemia

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Expression for genes affiliated with T-Cell Large Granular Lymphocyte Leukemia

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Search GEO for disease gene expression data for T-Cell Large Granular Lymphocyte Leukemia.

Pathways for genes affiliated with T-Cell Large Granular Lymphocyte Leukemia

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Pathways related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL2RA, STAT3
29.5IL2RA, STAT3
39.5STAT3, IL2RA
4
Show member pathways
IL-2 Signaling pathway36
9.5STAT3, IL2RA
5
Show member pathways
Immune response IL 12 induced IFN gamma production58
9.5IL2RA, STAT3
6
Show member pathways
9.5IL2RA, IL15RA
7
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.0STAT3, IL2RA, IL15RA
8
Show member pathways
Type III interferon signaling36
9.0IL2RA, STAT3, IL15RA
9
Show member pathways
8.7KLRD1, KLRK1, KIR2DL1, KIR2DL3
108.7KIR2DL1, KLRK1, KLRD1, KIR2DL3
11
Show member pathways
Immune response CD16 signaling in NK cells58
8.3KLRD1, KLRK1, KIR2DL1, KIR2DL3, MICA
12
Show member pathways
8.2KLRK1, KIR2DL1, KLRD1, STAT3, KIR2DL3
13
Show member pathways
7.6IL15RA, MICA, IL2RA, KIR2DL3, KIR2DL1, KLRD1

Compounds for genes affiliated with T-Cell Large Granular Lymphocyte Leukemia

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Compounds related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

(show all 29)
idCompoundScoreTop Affiliating Genes
1tuberculin4310.0LBR, IL2RA
2cuprophan4310.0LBR, IL2RA
3phorbol 12,13-dibutyrate4310.0IL2RA, LBR
4okt34310.0IL2RA, LBR
5con a4310.0IL2RA, LBR
6diethyl dithiocarbamate4310.0IL2RA, LBR
7sodium arsenite439.9LBR, IL2RA
8ouabain43 1210.9LBR, IL2RA
9polyinosinic-polycytidylic acid439.9KLRK1, STAT3
10infliximab43 49 1211.9LBR, IL2RA
11as 10143 5910.9STAT3, IL2RA
12pentoxifylline43 1210.8IL2RA, LBR
13ribavirin43 49 1211.8STAT3, LBR
14neopterin439.8LBR, IL2RA
15malondialdehyde439.7LBR, IL2RA
16ifn-alpha439.6STAT3, IL2RA
17cadmium43 2410.5IL2RA, STAT3, LBR
18rituximab43 49 1211.5STAT3, IL2RA
19vitamin-e439.5LBR, IL2RA, STAT3
20mifepristone43 28 59 1212.5IL2RA, STAT3, LBR
21rantes439.5STAT3, IL2RA, LBR
22rapamycin439.4LBR, IL2RA, STAT3
23genistein43 28 59 2 24 1214.4IL2RA, LBR, STAT3
24cyclosporin a43 28 5911.3LBR, IL2RA, STAT3
25heparin43 28 24 1212.1IL2RA, LBR, STAT3
26thymidine43 2410.0LBR, IL2RA, STAT3
27cisplatin43 49 59 1211.8IL2RA, STAT3, LBR
28arginine438.5GZMK, LBR, STAT3, IL2RA, KLRK1
29tyrosine438.1IL2RA, KLRD1, KIR2DL1, KIR2DL3, STAT3, LBR

GO Terms for genes affiliated with T-Cell Large Granular Lymphocyte Leukemia

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Cellular components related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00058867.5KLRD1, KIR2DL1, KIR2DL3, IL15RA, IL2RA, STAT3

Biological processes related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1JAK-STAT cascadeGO:00072599.3IL15RA, STAT3
2immune responseGO:00069559.1KIR2DL1, IL2RA, KIR2DL3
3regulation of immune responseGO:00507769.0KIR2DL3, KIR2DL1, KLRD1
4cell proliferationGO:00082839.0IL2RA, STAT3, IL15RA

Molecular functions related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1antigen bindingGO:00038239.7KIR2DL3, MICA

Products for genes affiliated with T-Cell Large Granular Lymphocyte Leukemia

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Sources for T-Cell Large Granular Lymphocyte Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet