T-LGL
MCID: TCL002
MIFTS: 48

T-Cell Large Granular Lymphocyte Leukemia (T-LGL) malady

Blood, Cancer, Immune categories

Summaries for T-Cell Large Granular Lymphocyte Leukemia

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A chronic lymphocytic leukemia that exhibits an unexplained, chronic (> 6 months) elevation in large granular lymphocytes (lgls) in the peripheral blood.

MalaCards: T-Cell Large Granular Lymphocyte Leukemia, also known as proliferation of large granular lymphocytes, is related to arthritis and hepatitis c. An important gene associated with T-Cell Large Granular Lymphocyte Leukemia is KIR2DL1 (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1), and among its related pathways are Legionellosis and Malaria. The compounds cycloheximide and pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, nk cells and t cells, and related mouse phenotypes are adipose tissue and digestive/alimentary.

Wikipedia:64 Large granular lymphocytic leukemia is a disease that exhibits an unexplained, chronic (> 6 months)... more...

Aliases & Classifications for T-Cell Large Granular Lymphocyte Leukemia

Sources:
8Disease Ontology, 45Novoseek, 49Orphanet, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood, Immune


Characteristics (Orphanet epidemiological data):

49

Aliases & Descriptions:

t-cell large granular lymphocyte leukemia 8 49 61
proliferation of large granular lymphocytes 49
leukemia, large granular lymphocytic 61
large granular lymphocytic leukemia 8
leukemia lymphocytic large granular 45
lown-ganong-levine syndrome 61
t-cell lgl leukemia 49
t-lgl 49


External Ids:

Disease Ontology8 DOID:0050751
MESH via Orphanet36 D054066
ICD10 via Orphanet26 C91.5
SNOMED-CT via Orphanet58 128819001, 55081009
UMLS via Orphanet62 C1955861

Related Diseases for T-Cell Large Granular Lymphocyte Leukemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to T-Cell Large Granular Lymphocyte Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 192)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.8IL8, TNF, IL6
2hepatitis c30.6TNF, IL10, IL18
3sjogren's syndrome30.6IL2RA
4graft versus host disease30.5IL18, IL10, IL15, IL2RA, TNF
5systemic lupus erythematosus30.5IL2RA, IL18, IL6, IL15, TNF, KLRK1
6thrombocytopenia30.4IL6
7celiac disease30.3MICA, KLRK1, IL15
8ulcerative colitis30.3STAT3, IL8, IL18, IL10, IL6, IL15
9large granular lymphocyte leukemia11.2
10lown-ganong-levine syndrome11.2
11t-cell leukemia11.0
12atrial tachyarrhythmia with short pr interval10.6
13leukemia/lymphoma, t-cell10.6
14plasma cell leukemia10.5
15splenomegaly10.5
16felty's syndrome10.5
17sudden infant death syndrome10.5
18hypertrophic cardiomyopathy10.5
19heart tumor10.5
20left ventricular noncompaction10.5
21autoimmune hemolytic anemia10.4
22n syndrome10.4
23hepatitis a10.4
24chronic active epstein-barr virus infection10.4
25gamma heavy chain disease10.4
26natural killer cell leukemia10.4
27protein-losing enteropathy10.4
28acute leukemia10.4
29char syndrome10.4
30chronic graft versus host disease10.4
31chronic myelomonocytic leukemia10.4
32leukemia, t-cell, chronic10.4
33essential thrombocythemia10.4
34autoimmune thrombocytopenic purpura10.3
35lambert-eaton myasthenic syndrome10.3
36acquired thrombocytopenia10.3
37common variable immunodeficiency10.3
38granular cell tumor10.3
39autoimmune hepatitis10.3
40malignant histiocytosis10.3
41granuloma annulare10.3
42acute lymphocytic leukemia10.3
43aplastic anemia10.3
44thrombocytopenia, acquired amegakaryocytic10.3
45lambert syndrome10.3
46leukemia, b-cell, chronic10.3
47lymphomatoid granulomatosis10.3
48bacteremia10.3
49hepatitis c virus10.3
50b-cell chronic lymphocytic leukemia10.3

Graphical network of the top 20 diseases related to T-Cell Large Granular Lymphocyte Leukemia:



Diseases related to t-cell large granular lymphocyte leukemia

Clinical Features for T-Cell Large Granular Lymphocyte Leukemia

Drugs & Therapeutics for T-Cell Large Granular Lymphocyte Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for T-Cell Large Granular Lymphocyte Leukemia

Drug clinical trials:

Search ClinicalTrials for T-Cell Large Granular Lymphocyte Leukemia

Search NIH Clinical Center for T-Cell Large Granular Lymphocyte Leukemia

Search CenterWatch for T-Cell Large Granular Lymphocyte Leukemia

Genetic Tests for T-Cell Large Granular Lymphocyte Leukemia

Anatomical Context for T-Cell Large Granular Lymphocyte Leukemia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to T-Cell Large Granular Lymphocyte Leukemia:

33
Bone marrow, Nk cells, T cells, B cells

Animal Models for T-Cell Large Granular Lymphocyte Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to T-Cell Large Granular Lymphocyte Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.2IL18
2MP:00053817.6IL18, IL10, IL2RA, STAT3, TRG, LBR
3MP:00053846.0IL10, IL6, IL18, IL15RA, IL15, IL2RA
4MP:00053975.9TNF, LBR, STAT3, IL2RA, IL6, IL15
5MP:00053875.5IL15RA, KLRK1, TNF, LBR, TRG, STAT3

Publications for T-Cell Large Granular Lymphocyte Leukemia

Sources:
51PubMed
See all sources

Articles related to T-Cell Large Granular Lymphocyte Leukemia:

(show all 35)
idTitleAuthorsYear
1
Lack of common TCRA and TCRB clonotypes in CD8(+)/TCRI+I^(+) T-cell large granular lymphocyte leukemia: a review on the role of antigenic selection in the immunopathogenesis of CD8(+) T-LGL. (24413066)
2014
2
Treatment of T-cell large granular lymphocyte leukemia with cyclosporine A: experience in a Chinese single institution. (23395383)
2013
3
Developing an in vitro model of T cell type of large granular lymphocyte leukemia. (24183305)
2013
4
Long-term remission of T-cell large granular lymphocyte leukemia associated with rheumatoid arthritis after rituximab therapy. (23869084)
2013
5
Large granular lymphocyte leukemia associated with hepatitis C virus infection and B cell lymphoma: improvement after antiviral therapy. (23176408)
2013
6
Extracorporeal photopheresis as a curative treatment strategy in non epidermotropic T-cell lymphoma and large granular lymphocyte leukemia. (22422944)
2012
7
Dynamical and structural analysis of a T cell survival network identifies novel candidate therapeutic targets for large granular lymphocyte leukemia. (22102804)
2011
8
Long-term safety and efficacy of cyclosporin A therapy for T-cell large granular lymphocyte leukemia. (20038217)
2010
9
Leg ulcer and thigh telangiectasia associated with natural killer cell CD56(-) large granular lymphocyte leukemia in a patient with pseudo-Felty syndrome. (19962215)
2010
10
Rapid and durable molecular response of refractory T-cell large granular lymphocyte leukemia after alemtuzumab treatment. (20211489)
2010
11
Therapeutic implications of variable expression of CD52 on clonal cytotoxic T cells in CD8+ large granular lymphocyte leukemia. (19794084)
2009
12
A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia. (19075187)
2009
13
Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia associated with an occult large granular lymphocyte leukemia. (17915315)
2008
14
The gammadelta variant of T cell large granular lymphocyte leukemia is very similar to the common alphabeta type: report of two cases. (19669213)
2008
15
Long-term responses and outcomes following immunosuppressive therapy in large granular lymphocyte leukemia-associated pure red cell aplasia: a Nationwide Cohort Study in Japan for the PRCA Collaborative Study Group. (18641028)
2008
16
Malignant transformation of T-cell large granular lymphocyte leukemia in a dog. (17611371)
2007
17
CD20- and CD56-positive T-cell large granular lymphocyte leukemia in a human T-cell leukemia virus type 1 carrier. (18055343)
2007
18
T-cell large granular lymphocyte leukemia of donor origin after cord blood transplantation. (17875238)
2007
19
Fludarabine, mitoxantrone and dexamethasone as first-line treatment for T-cell large granular lymphocyte leukemia. (17525720)
2007
20
Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia. (16387851)
2006
21
CD52 expression in T-cell large granular lymphocyte leukemia--implications for treatment with alemtuzumab. (16019510)
2005
22
Remission of pure red cell aplasia in T-cell receptor gammadelta-large granular lymphocyte leukemia after therapy with low-dose alemtuzumab. (16193089)
2005
23
Allogeneic hematopoietic stem cell transplantation in a patient affected by large granular lymphocyte leukemia and multiple sclerosis. (14648027)
2004
24
T-cell large granular lymphocyte leukemia of donor origin after allogeneic bone marrow transplantation. (14560574)
2003
25
T-cell large granular lymphocyte leukemia is characterized by massive TCRBV-restricted clonal CD8 expansion and a generalized overexpression of the effector cell marker CD57. (12692516)
2003
26
T-gamma large granular lymphocyte leukemia associated with amegakaryocytic thrombocytopenic purpura, SjAPgren's syndrome, and polyglandular autoimmune syndrome type II, with subsequent development of pure red cell aplasia. (11835350)
2002
27
Aggressive variant of morphologically typical T large granular lymphocyte leukemia/lymphoma lacking NK cell markers. (11154985)
2000
28
Pure red cell aplasia (PRCA) with thymoma: a possible distinct clinical entity distinct from large granular lymphocyte (LGL) leukemia. (10629578)
2000
29
Improvement of extrathymic T cell type of large granular lymphocyte (LGL) leukemia by cyclosporin A: the serum level of Fas ligand is a marker of LGL leukemia activity. (11073168)
2000
30
Large granular lymphocyte leukemia with pure red cell aplasia in a renal transplant recipient. (9423821)
1998
31
Neutropenia associated with T-cell large granular lymphocyte leukemia: long-term response to cyclosporine therapy despite persistence of abnormal cells. (9558395)
1998
32
Effective autologous peripheral blood stem cell transplantation in plasma cell leukemia followed by T-large granular lymphocyte expansion: a case report. (8832022)
1996
33
Large granular lymphocyte leukemia presenting with both amegakaryocytic thrombocytopenic purpura and pure red cell aplasia: clinical course and response to immunosuppressive therapy. (7604815)
1995
34
Detection of human T-cell leukemia/lymphoma virus, type II, in a patient with large granular lymphocyte leukemia. (1355373)
1992
35
Hairy cell leukemia associated with large granular lymphocyte leukemia: immunologic and genomic study, effect of interferon treatment. (2840988)
1988

Genetic Variations for T-Cell Large Granular Lymphocyte Leukemia

Expression for genes affiliated with T-Cell Large Granular Lymphocyte Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with T-Cell Large Granular Lymphocyte Leukemia

Search GEO for disease gene expression data for T-Cell Large Granular Lymphocyte Leukemia.

Pathways for genes affiliated with T-Cell Large Granular Lymphocyte Leukemia

Sources:
30KEGG, 38NCBI BioSystems Database, 54Reactome, 52QIAGEN, 12EMD Millipore, 53R&D Systems
See all sources

Pathways related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

(show all 45)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IL8
29.9KLRK1, IL18
39.9IL6, TNF
4
Hide members
9.9IL15RA
5
Hide members
9.7KIR2DL1, KIR2DL3, MICA
69.7IL18, IL8, IL6
7
Hide members
9.6TNF, IL2RA, IL8
8
Hide members
9.6IL2RA, IL15RA
99.6TNF, IL2RA, IL6
10
Hide members
9.6TNF, IL8, IL6
11
Immune response Bacterial infections in normal airways
9.6IL6, IL8, TNF
129.6IL8, TNF, IL6
139.6IL18, IL2RA, STAT3
14
Hide members
9.6IL2RA, STAT3, IL18
15
Cytokine production by Th17 cells in CF (Mouse model)
9.5STAT3, IL8, IL6
169.4IL15, IL18
17
Hide members
9.3TNF, IL6, IL18, IL8
18
Hide members
9.3IL8, TNF, IL6, IL18
199.3IL18, IL10, TNF, IL6
209.3IL18, IL6, TNF, IL10
219.3IL6, TNF, IL8, IL10
229.3IL6, IL10, TNF, IL8
239.3IL8, TNF, IL10, IL6
24
Hide members
9.3STAT3, IL2RA, IL6, IL18
25
Hide members
9.3IL18, IL6, IL2RA, STAT3
269.3IL8, STAT3, IL2RA, IL6
279.2STAT3, IL10, TNF, IL6
289.0IL6, IL15, TNF
29
Hide members
8.9IL10, TNF, STAT3, IL18, IL6
30
Development PDGF signaling via STATs and NF-kB
Hide members
8.9IL6, TNF, STAT3, IL18, IL10
31
Hide members
8.9TNF, STAT3, IL18, IL10, IL6
32
Hide members
8.9STAT3, IL6, TNF, IL8, IL10
33
Hide members
8.8IL2RA, IL15, IL15RA
348.8IL15, IL2RA, IL15RA
35
Hide members
8.8IL2RA, IL15RA, IL15
36
Hide members
8.5KIR2DL3, MICA, TNF, KIR2DL1, KLRK1, KLRD1
37
Hide members
8.4IL18, IL15RA, IL15, STAT3
388.2IL6, IL15, IL10, IL18, TNF, IL8
39
Hide members
8.2TNF, IL10, IL15RA, IL15, IL2RA
40
Hide members
8.1IL6, KLRK1, MICA, IL18, IL2RA, KLRD1
41
Hide members
7.9IL2RA, TNF, STAT3, IL6, IL8, IL18
427.8STAT3, IL6, IL10, IL15RA, IL15, IL2RA
43
Hide members
7.8IL15RA, IL15, TNF, IL2RA, STAT3, IL6
44
Hide members
7.2IL18, KLRD1, IL15, IL15RA, IL10, TNF
45
Hide members
7.0IL18, TNF, IL15RA, IL2RA, IL15, STAT3

Compounds for genes affiliated with T-Cell Large Granular Lymphocyte Leukemia

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 2BitterDB, 60Tocris Bioscience, 50PharmGKB, 24HMDB
See all sources

Compounds related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.6IL18
2pentoxifylline45 1111.4IL18, LBR
3gm-csf45 2911.3TNF, IL10
4prednisolone45 29 1112.3IL2RA
5hydrocortisone45 2 60 1113.2IL8
6cdp571459.7IL6, IL10, TNF
7natalizumab45 1110.7IL18, IL10, IL2RA, TNF
8con a459.7IL10, LBR, IL18, IL2RA
95 aminosalicylic acid459.7IL10, IL8, TNF, IL2RA
10mip 1alpha459.7IL10, TNF, IL8, IL6
112,5-oligoadenylate459.6IL2RA, TNF
12polymyxin b459.6IL6, IL10, TNF, IL8
13toxin-1459.5IL8, IL10, TNF, KLRD1
14imiquimod45 29 60 1112.5IL18, IL10, IL6, IL8, TNF
15groalpha459.5IL6, IL18, IL10, TNF, IL8
16lipoteichoic acid459.4IL10, IL18, IL8, IL6, TNF
17ifn-alpha459.3IL10, IL18, IL2RA, STAT3, IL6
18parthenolide45 210.3STAT3, TNF, IL6, IL8
19ciglitazone45 2910.3IL6, IL8, TNF, STAT3
20atorvastatin45 50 29 11 2413.3IL6, IL18, IL10, IL2RA, TNF
21pdtc459.3STAT3, TNF, IL6, IL8, IL18
2215-deoxy-delta-12,14-prostaglandin j2459.2IL8, IL6, IL10, STAT3, TNF
238-isoprostane459.2IL6, IL8, IL10, TNF
24sp 60012545 6010.2IL6, IL8, TNF, STAT3, IL18
25cyclosporin a45 29 6011.2LBR, IL15, IL2RA, STAT3
26dexamethasone45 50 29 1112.1LBR, STAT3, IL6, IL15
27thalidomide45 50 60 1112.1TNF, IL2RA, IL10, IL18, STAT3, IL6
28tuberculin459.1IL2RA, IL18, LBR, IL10, IL15
29neopterin459.0TNF, LBR, IL2RA, IL18, IL8, IL6
30n acetylcysteine458.9IL8, IL6, TNF, IL18, IL2RA, STAT3
31poly(i-c)458.9IL8, TNF, IL15, IL18, IL6
32sb 20358045 609.9STAT3, IL8, TNF, IL10, IL6, IL18
33peptidoglycan45 299.9IL15, TNF, IL10, IL8, IL6
34chloroquine45 2 50 29 1112.9IL18, IL2RA, TNF, IL15, IL10
35okt3458.7IL15, IL2RA, IL10, LBR, TNF, IL6
36ionomycin458.7LBR, IL18, TNF, IL15, IL2RA, IL10
37il-12458.7TNF, IL15, IL10, IL18, IL8, IL6
38etanercept45 50 1110.7IL10, IL18, TNF, IL15, IL8, IL6
39ccl345 299.6TNF, IL15, IL10, IL6, IL18, IL8
40rantes458.6IL2RA, STAT3, TNF, IL6, IL15, LBR
41methotrexate45 50 1110.6TNF, IL15, IL10, IL18, IL6, IL2RA
42rituximab45 50 1110.5TNF, IL2RA, IL6, IL10, IL15, STAT3
43infliximab45 50 1110.5IL6, IL10, IL18, TNF, IL15, LBR
44curcumin458.4IL6, IL18, IL15, STAT3, TNF, IL8
45il 10458.4IL10, IL2RA, IL15, TNF, IL6, IL8
46rapamycin458.2IL2RA, LBR, IL15, IL10, IL18, STAT3
47histamine45 29 2410.2LBR, IL6, IL8, IL18, IL10, IL15
48thymidine45 249.0IL6, IL18, IL15, IL2RA, STAT3, LBR
49polyinosinic-polycytidylic acid457.9IL6, TNF, IL8, IL15, STAT3, KLRK1
50vegf457.9IL2RA, IL15, IL6, IL18, IL8, IL10

GO Terms for genes affiliated with T-Cell Large Granular Lymphocyte Leukemia

Sources:
16Gene Ontology
See all sources

Cellular components related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.2IL6, IL2RA, TNF, KLRD1
2extracellular spaceGO:0056156.9IL6, TNF, MICA, IL15, IL15RA, IL10

Biological processes related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cytokine secretion involved in immune responseGO:00274010.5IL10
2type 2 immune responseGO:04209210.2IL18, IL10
3receptor biosynthetic processGO:03280010.2IL10, TNF
4epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.1TNF, IL6
5negative regulation of lipid storageGO:01088810.1IL6, TNF
6response to molecule of bacterial originGO:00223710.1IL10, IL8
7interleukin-6-mediated signaling pathwayGO:07010210.0IL6, STAT3
8positive regulation of chemokine productionGO:0327229.9TNF, IL18, IL6
9embryonic digestive tract developmentGO:0485669.9TNF, IL8
10response to glucocorticoid stimulusGO:0513849.8TNF, IL10, IL6
11positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.7TNF, IL10, IL6
12positive regulation of tissue remodelingGO:0341059.7IL15, IL18
13positive regulation of natural killer cell proliferationGO:0328199.7IL15, IL18
14negative regulation of growth of symbiont in hostGO:0441309.6TNF, IL10
15regulation of immune responseGO:0507769.5KLRD1, KIR2DL3, KIR2DL1
16positive regulation of interleukin-17 productionGO:0327409.4IL15, IL18
17response to drugGO:0424939.2TNF, STAT3, IL10, IL6
18positive regulation of natural killer cell differentiationGO:0328259.1IL15, IL15RA
19immune responseGO:0069558.8IL8, IL15, IL2RA, KIR2DL3, KIR2DL1, IL18
20inflammatory responseGO:0069548.6IL10, TNF, IL15, IL18, IL8, IL6

Molecular functions related to T-Cell Large Granular Lymphocyte Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.5IL6, IL18, IL10, IL15, TNF

Products for genes affiliated with T-Cell Large Granular Lymphocyte Leukemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for T-Cell Large Granular Lymphocyte Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet