MCID: TCL004
MIFTS: 50

T-Cell Leukemia malady

Cancer diseases, Immune diseases, Skin diseases, Blood diseases, Rare diseases categories

Summaries for T-Cell Leukemia

About this section
Sources:
66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 T-cell leukemia describes several different types of lymphoid leukemia which affect T cells. more...

MalaCards: T-Cell Leukemia, also known as leukemia, t-cell, is related to leukemia and lymphoblastic leukemia. An important gene associated with T-Cell Leukemia is TAL1 (T-cell acute lymphocytic leukemia 1). Affiliated tissues include t cells, skin and b cells, and related mouse phenotypes are nervous system and cellular.

Aliases & Classifications for T-Cell Leukemia

About this section
Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH
See all sources

Classifications:



Aliases & Descriptions:

t-cell leukemia 9 11
leukemia, t-cell 63
leukemia t-cell 46


External Ids:

Disease Ontology9 DOID:715
MeSH36 D015458

Related Diseases for T-Cell Leukemia

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Acute T Cell Leukemia family:

Adult T-Cell Leukemia t-cell leukemia
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic

Diseases related to T-Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.5TLX3, TLX1, TCL1A, HTLVR, TAL1, CD7
2lymphoblastic leukemia30.5TLX1
3lymphoblastic lymphoma30.1CD7, TAL1
4adult t-cell leukemia11.5
5human t-cell leukemia virus type 111.4
6human t-cell leukemia virus type 210.9
7spastic paraparesis10.8
8spasticity10.8
9tropical spastic paraparesis10.8
10acute t cell leukemia10.8
11hypercalcemia10.7
12hematopoietic stem cell transplantation10.7
13hepatitis10.5
14endotheliitis10.5
15hiv-110.5
16mycosis fungoides10.5
17scabies10.5
18cutaneous t cell lymphoma10.4
19pneumonia10.4
20human t-cell leukemia virus type 310.4
21peripheral t-cell lymphoma10.4
22hepatitis c10.4
23strongyloidiasis10.4
24arthritis10.4
25dermatitis10.4
26eosinophilia10.4
27herpes simplex10.4
28prolymphocytic leukemia10.4
29retinitis10.4
30b-cell lymphomas10.4
31pediatric t-cell leukemia10.4
32hepatitis c virus10.4
33graft versus host disease10.3
34acute pancreatitis10.3
35follicular mucinosis10.3
36norwegian scabies10.3
37arthropathy10.3
38chronic lymphocytic leukemia10.3
39hodgkin's lymphoma10.3
40meningitis10.3
41neuropathy10.3
42pancreatitis10.3
43uveitis10.3
44htlv-1 associated myelopathy/tropical spastic paraparesis10.3
45large granular lymphocyte leukemia10.3
46t-cell prolymphocytic leukemia10.3
47acute liver failure10.2
48neuronitis10.2
49gastric lymphoma10.2
50hepatitis b10.2

Graphical network of the top 20 diseases related to T-Cell Leukemia:



Diseases related to t-cell leukemia

Symptoms for T-Cell Leukemia

About this section

Drugs & Therapeutics for T-Cell Leukemia

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for T-Cell Leukemia

Drug clinical trials:

Search ClinicalTrials for T-Cell Leukemia

Search NIH Clinical Center for T-Cell Leukemia

Search CenterWatch for T-Cell Leukemia

Genetic Tests for T-Cell Leukemia

About this section

Anatomical Context for T-Cell Leukemia

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to T-Cell Leukemia:

34
T cells, Skin, B cells, Bone, Lung, Liver, Endothelial, Monocytes, Bone marrow, Lymph node, Myeloid, Colon, Breast, Retina, Brain, Testes, Testis, Thyroid, Thymus, Spleen, Pituitary

Animal Models for T-Cell Leukemia or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to T-Cell Leukemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.4SLC2A1, TAL1, PBX2, VAC14, PMAIP1, TLX3
2MP:00053848.3PMAIP1, VAC14, PBX2, TAX1BP1, TAL1, SLC2A1
3MP:00053878.3PDLIM2, TAL1, TAX1BP1, PBX2, PMAIP1, TLX1
4MP:00053978.2TLX1, PMAIP1, PBX2, PDLIM2, TAX1BP1, TAL1
5MP:00107687.6SLC2A1, TLX2, TLX3, PMAIP1, EPC1, VAC14

Publications for T-Cell Leukemia

About this section
Sources:
53PubMed
See all sources

Articles related to T-Cell Leukemia:

(show top 50)    (show all 1619)
idTitleAuthorsYear
1
LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription. (23577667)
2013
2
Stevens-Johnson Syndrome associated with mogamulizumab treatment of adult T-cell leukemia / lymphoma. (23360455)
2013
3
CD4 and CD8 double-negative adult T-cell leukemia/lymphoma with monomorphic cells expressing CD99: a diagnostic challenge in a country non-endemic for human T-cell leukemia virus. (23464972)
2013
4
Human T cell leukemia virus type 2 tax-mediated NF-I_B activation involves a mechanism independent of Tax conjugation to ubiquitin and SUMO. (23135727)
2013
5
Mogamulizumab for the treatment of adult T-cell leukemia/lymphoma. (23110261)
2012
6
Increase in incidence of adult T-cell leukemia/lymphoma in non-endemic areas of Japan and the United States. (22738276)
2012
7
Targeting Bcl-2 family proteins in adult T-cell leukemia/lymphoma: in vitro and in vivo effects of the novel Bcl-2 family inhibitor ABT-737. (22138435)
2012
8
Anti-adult T-cell leukemia effects of Bidens pilosa. (21318218)
2011
9
C-terminal domain modulates the nucleic acid chaperone activity of human T-cell leukemia virus type 1 nucleocapsid protein via an electrostatic mechanism. (19887455)
2010
10
Clinical and laboratory features in adult T-cell leukemia/lymphoma in Khorasan, Iran. (20178409)
2010
11
Features of primary extranodal lymphoma in Kanagawa, a human T-cell leukemia virus type 1 nonendemic area in Japan. (18568429)
2009
12
PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients. (18830259)
2009
13
Human T-cell leukemia virus type 1 infection leads to arrest in the G1 phase of the cell cycle. (18596104)
2008
14
Rearranged NF-kappa B2 gene in an adult T-cell leukemia cell line. (18377428)
2008
15
Fludarabine induces apoptosis of human T-cell leukemia virus type 1-infected T cells via inhibition of the nuclear factor-kappaB signal pathway. (17344917)
2007
16
The role of WWP1-Gag interaction and Gag ubiquitination in assembly and release of human T-cell leukemia virus type 1. (17609263)
2007
17
Stem cell properties and the side population cells as a target for interferon-alpha in adult T-cell leukemia/lymphoma. (17977513)
2007
18
NOTCH1-induced T-cell leukemia in transgenic zebrafish. (17252014)
2007
19
Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. (17173050)
2007
20
Inactivation of p14ARF as a key event for the progression of adult T cell leukemia/lymphoma. (18246599)
2007
21
Mature T-cell leukemias including T-prolymphocytic leukemia, adult T-cell leukemia/lymphoma, and SAczary syndrome. (17369126)
2007
22
Blocking NF-kappaB as a potential strategy to treat adult T-cell leukemia/lymphoma. (16823495)
2006
23
Comparison of antigenic sites of the envelope glycoprotein of the Iranian isolate of human T-cell leukemia virus type 1 with different subtypes of the virus. (16883437)
2006
24
Induction of human T cell leukemia virus type I receptors on quiescent naive T lymphocytes by TGF-beta. (15778389)
2005
25
Transcriptional regulation of parathyroid hormone-related protein promoter P3 by ETS-1 in adult T-cell leukemia/lymphoma. (15889157)
2005
26
Identification of two new HLA-A*1101-restricted tax epitopes recognized by cytotoxic T lymphocytes in an adult T-cell leukemia patient after hematopoietic stem cell transplantation. (16014972)
2005
27
Narrow substrate specificity and sensitivity toward ligand-binding site mutations of human T-cell Leukemia virus type 1 protease. (15102858)
2004
28
Tax-independent constitutive IkappaB kinase activation in adult T-cell leukemia cells. (15153339)
2004
29
Deoxycoformycin-containing combination chemotherapy for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study (JCOG9109). (12627852)
2003
30
Human T-cell leukemia virus type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax. (11861831)
2002
31
Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12(I) protein. (11390610)
2001
32
The contribution of NF-kappa B activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 Tax-induced tumors. (11493471)
2001
33
Identification of a human T-cell leukemia virus type I tax peptide in contact with DNA. (10567395)
1999
34
Multiple osteolysis of peripheral extremities in a patient with adult T cell leukemia/lymphoma. (10526948)
1999
35
The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IkappaB kinases containing IKKalpha and IKKbeta. (9632633)
1998
36
Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb. (9584203)
1998
37
The human T-cell leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor groove. (9668114)
1998
38
Molecular analysis of the t(8;14)(q24;q11) chromosomal breakpoint junctions in the T-cell leukemia line MOLT-16. (9408752)
1997
39
Role of intracellular redox status in apoptosis induction of human T-cell leukemia virus type I-infected lymphocytes by 13-cis-retinoic acid. (9354458)
1997
40
Among all human T-cell leukemia virus type 1 proteins, tax, polymerase, and envelope proteins are predicted as preferential targets for the HLA-A2-restricted cytotoxic T-cell response. (8763995)
1996
41
Imidazole antifungals Miconazole and Econazole induce apoptosis in mouse lymphoma and human T cell leukemia cells: regulation by Bcl-2 and potential role of calcium. (17180102)
1996
42
Prevalence of human T-cell leukemia virus type 1 (HTLV-I) in family members of adult T-cell leukemia (ATL) patients in non-ATL-endemic Hokkaido of Japan. (7669948)
1995
43
Adhesion properties of adult T cell leukemia cells. (7787750)
1995
44
Mitochondrial induction of adult T cell leukemia derived factor (ADF/hTx) after oxidative stresses in retinal pigment epithelial cells. (8206709)
1994
45
Phorbol esters modulate the phosphorylation of human T-cell leukemia virus type I Tax. (8510230)
1993
46
A new regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1 and cloning of cDNAs encoding its binding proteins. (8350401)
1993
47
In vitro infection of human macrophages with human T-cell leukemia virus type 1. (8453107)
1993
48
Reactive oxygen-reducing and protein-refolding activities of adult T cell leukemia-derived factor/human thioredoxin. (1510657)
1992
49
Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1. (3024966)
1986
50
t(11;19)(q23;p11) in a child with acute T-cell leukemia. (3855377)
1985

Variations for T-Cell Leukemia

About this section

Expression for genes affiliated with T-Cell Leukemia

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with T-Cell Leukemia

Search GEO for disease gene expression data for T-Cell Leukemia.

Pathways for genes affiliated with T-Cell Leukemia

About this section

Compounds for genes affiliated with T-Cell Leukemia

About this section

GO Terms for genes affiliated with T-Cell Leukemia

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056348.3TAL1, PDLIM2, FOXN2, PBX2, EPC1, PMAIP1

Biological processes related to T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell fate commitmentGO:04516510.1TAL1, TLX1
2cellular response to glucose starvationGO:0421499.8SLC2A1, PMAIP1

Molecular functions related to T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kinase bindingGO:0199009.7SLC2A1, TAX1BP1
2sequence-specific DNA bindingGO:0435659.2FOXN2, PBX2, TLX2, TLX1, TLX3
3sequence-specific DNA binding transcription factor activityGO:0037008.8TLX3, TLX1, TLX2, PBX2, FOXN2, TAL1

Products for genes affiliated with T-Cell Leukemia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for T-Cell Leukemia

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet