MCID: TCL004
MIFTS: 50

T-Cell Leukemia

Categories: Rare diseases, Immune diseases, Blood diseases, Skin diseases, Cancer diseases

Aliases & Classifications for T-Cell Leukemia

MalaCards integrated aliases for T-Cell Leukemia:

Name: T-Cell Leukemia 12 14
Leukemia, T-Cell 41 69
Leukemia T-Cell 51

Classifications:



External Ids:

Disease Ontology 12 DOID:715
MeSH 41 D015458
UMLS 69 C0023492

Summaries for T-Cell Leukemia

MalaCards based summary : T-Cell Leukemia, also known as leukemia, t-cell, is related to adult t-cell leukemia and human t-cell leukemia virus type 2. An important gene associated with T-Cell Leukemia is TCL1A (T Cell Leukemia/Lymphoma 1A), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Insulin resistance. The drugs Vincristine and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow.

Related Diseases for T-Cell Leukemia

Diseases in the T-Cell Leukemia family:

Adult T-Cell Leukemia Acute T Cell Leukemia
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic

Diseases related to T-Cell Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 199)
# Related Disease Score Top Affiliating Genes
1 adult t-cell leukemia 34.4 CD7 CNTN2 PMAIP1
2 human t-cell leukemia virus type 2 34.2 CNTN2 CREB1
3 human t-cell leukemia virus type 1 33.9 CNTN2 CREB1 CRTC2 GLI2
4 acute t cell leukemia 33.5 CD7 LMO1
5 leukemia 32.0 TAL1 TCL1A TCL1B TCTA TLX1 TLX3
6 lymphoblastic leukemia 29.9 LMO1 TLX1 TLX3
7 human t-cell leukemia virus type 3 12.1
8 pediatric t-cell leukemia 12.1
9 leukemia, t-cell, chronic 11.6
10 htlv-1 associated myelopathy/tropical spastic paraparesis 11.5
11 t-cell prolymphocytic leukemia 11.5
12 myelopathy, htlv-1-associated 11.4
13 tropical spastic paraparesis 11.4
14 netherton syndrome 11.2
15 lymphoma 11.0
16 retrovirus-associated myelopathy 11.0
17 hepatosplenic t-cell lymphoma 10.8
18 chronic interstitial cystitis 10.6
19 alcoholic hepatitis 10.5
20 follicular lymphoma 10.5
21 agammaglobulinemia 10.5
22 spastic paraparesis 10.5
23 spasticity 10.5
24 hematopoietic stem cell transplantation 10.4
25 hypercalcemia, infantile, 1 10.3
26 immunodeficiency 18 10.3 LMO1 TAL1
27 hepatitis 10.2
28 blood group, i system 10.1
29 endotheliitis 10.1
30 mycosis fungoides 10.1
31 pneumonia 10.1
32 human immunodeficiency virus type 1 10.1
33 peripheral t-cell lymphoma 10.1
34 scabies 10.1
35 graft-versus-host disease 10.0
36 arthritis 10.0
37 cutaneous t cell lymphoma 10.0
38 prolymphocytic leukemia 10.0
39 uveitis 10.0
40 dermatitis 10.0
41 hepatitis c virus 10.0
42 b-cell lymphomas 10.0
43 hepatitis b 10.0
44 strongyloidiasis 10.0
45 hepatitis c 10.0
46 retinitis 10.0
47 arthropathy 10.0
48 herpes simplex 10.0
49 meningitis 10.0
50 follicular mucinosis 10.0

Graphical network of the top 20 diseases related to T-Cell Leukemia:



Diseases related to T-Cell Leukemia

Symptoms & Phenotypes for T-Cell Leukemia

Drugs & Therapeutics for T-Cell Leukemia

Drugs for T-Cell Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 387)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 2068-78-2, 57-22-7 5978
2
Etoposide Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 33419-42-0 36462
3
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
4
Gemcitabine Approved Phase 4,Phase 2,Phase 1 95058-81-4 60750
5
Ifosfamide Approved Phase 4,Phase 2,Phase 1 3778-73-2 3690
6
Epirubicin Approved Phase 4,Phase 2 56420-45-2 41867
7
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
8
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-02-2 5743
9
Cisplatin Approved Phase 4,Phase 2,Phase 1 15663-27-1 2767 441203 84093
10
Daclizumab Approved, Investigational Phase 4,Phase 1,Phase 2 152923-56-3
11 Isophosphamide mustard Phase 4,Phase 2,Phase 1 0
12 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
13 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
14 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
15 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
16 Hormones Phase 4,Phase 3,Phase 2,Phase 1
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
18 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
19 Immunoglobulins Phase 4,Phase 3,Phase 1,Phase 2
20 Etoposide phosphate Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
21 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
22 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
23 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
24 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
25 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
26 Antibodies Phase 4,Phase 3,Phase 1,Phase 2
27 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
29 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1177-87-3
30 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
31
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1,Early Phase 1 23214-92-8 31703
32
Cytarabine Approved, Investigational Phase 3,Phase 2,Phase 1,Early Phase 1 147-94-4 6253
33
Methotrexate Approved Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
34
Melphalan Approved Phase 2, Phase 3,Phase 1 148-82-3 460612 4053
35
Carboplatin Approved Phase 2, Phase 3,Phase 1 41575-94-4 10339178 38904 498142
36
Mycophenolic acid Approved Phase 3,Phase 2,Phase 1,Not Applicable 24280-93-1 446541
37
Mycophenolate mofetil Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 128794-94-5 5281078
38
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1 2764
39
Fludarabine Approved Phase 3,Phase 2,Phase 1,Not Applicable 21679-14-1, 75607-67-9 30751
40
Busulfan Approved, Investigational Phase 2, Phase 3,Phase 1,Early Phase 1 55-98-1 2478
41
rituximab Approved Phase 3,Phase 1,Phase 2,Early Phase 1 174722-31-7 10201696
42
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 22916-47-8 4189
43
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
44
Ofloxacin Approved Phase 3 82419-36-1 4583
45
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613 2171
46 Thiotepa Approved, Investigational Phase 2, Phase 3,Phase 1 52-24-4 5453
47
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
48
Cefepime Approved, Investigational Phase 3 88040-23-7 5479537
49
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
50
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772

Interventional clinical trials:

(show top 50) (show all 345)

# Name Status NCT ID Phase Drugs
1 Pilot Study of Combination Therapy With CHOP-Zenapax (CHOP-daclizumab) Completed NCT01418430 Phase 4 CHOP-daclizumab
2 CEOP/IVE/GDP Compared With CEOP as the First-line Therapy for Newly Diagnosed Adult Patients With PTCL Recruiting NCT02533700 Phase 4 CEOP/IVE/GDP chemotherapy regimen;CEOP chemotherapy regimen for 6 cycles
3 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Active, not recruiting NCT03226119 Phase 4
4 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
5 Early Hospital Discharge or Standard Inpatient Care in Cancer Patients Receiving Antibiotics for Febrile Neutropenia Unknown status NCT00445497 Phase 3 amoxicillin-clavulanate potassium;ciprofloxacin
6 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
7 Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma Unknown status NCT00052936 Phase 3 CHOP regimen;cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
8 A Study for Aggressive Adult T-cell Leukemia-lymphoma (ATLL) Completed NCT00145002 Phase 3 VCAP-AMP-VECP with G-CSF and intrathecal prophylaxis;biweekly-CHOP with G-CSF and intrathecal prophylaxis
9 Radiation Therapy in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma Who Have Undergone Stem Cell Transplantation Completed NCT00031668 Phase 3
10 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
11 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3 American ginseng
12 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
13 Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
14 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
15 St. John's Wort in Relieving Fatigue in Patients Undergoing Chemotherapy or Hormone Therapy for Cancer Completed NCT00005805 Phase 3
16 Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count Completed NCT00003805 Phase 3 piperacillin sodium;piperacillin-tazobactam;tazobactam sodium;vancomycin
17 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3 Fragmin
18 Darbepoetin Alfa Compared With Epoetin Alfa in Treating Anemia in Patients Receiving Chemotherapy for Cancer Completed NCT00070382 Phase 3 darbepoetin alfa;epoetin alfa
19 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
20 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
21 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
22 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
23 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3 ondansetron
24 Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant Completed NCT01231412 Phase 3 Cyclosporine;Fludarabine Phosphate;Mycophenolate Mofetil;Sirolimus
25 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma Active, not recruiting NCT00408005 Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin Hydrochloride;Leucovorin Calcium;Mercaptopurine;Methotrexate;Nelarabine;Pegaspargase;Prednisone;Thioguanine;Vincristine Sulfate
26 Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer Active, not recruiting NCT00003816 Phase 2, Phase 3 busulfan;carboplatin;cyclophosphamide;etoposide;fludarabine phosphate;melphalan;thiotepa
27 Combination Chemotherapy With or Without Etoposide in Treating Older Patients With Non-Hodgkin's Lymphoma Terminated NCT00060385 Phase 2, Phase 3 CHOP regimen;EPOCH regimen;cyclophosphamide;doxorubicin hydrochloride;etoposide;prednisone;vincristine sulfate
28 High-Dose Chemotherapy Given Together With Peripheral Blood Stem Cell Transplant in Treating Patients With Intestinal T-Cell Lymphoma Unknown status NCT00669812 Phase 2 carmustine;cyclophosphamide;cytarabine;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;melphalan;methotrexate;prednisolone;vincristine sulfate
29 Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas Unknown status NCT01805037 Phase 1, Phase 2 brentuximab vedotin
30 Combination Chemotherapy Followed by Donor Bone Marrow Transplant or Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer or Genetic Disorders Unknown status NCT00008307 Phase 2 cyclosporine;fludarabine phosphate;melphalan;methylprednisolone;mycophenolate mofetil
31 Alemtuzumab and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV T-Cell Non-Hodgkin's Lymphoma Unknown status NCT00363090 Phase 1, Phase 2 cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
32 Vaccine Therapy and GM-CSF in Treating Patients With CNS Lymphoma Unknown status NCT00621036 Phase 2 methotrexate;thiotepa
33 Stem Cell Transplant in Treating Patients With Hematological Cancer or Other Disorders Unknown status NCT00740467 Phase 2 busulfan;cyclophosphamide;cyclosporine;fludarabine phosphate;mycophenolate mofetil
34 Arsenic Trioxide in Treating Patients With Recurrent or Refractory Acute Leukemia, Chronic Myeloide Leukemia, Myelodysplasia, Lymphoma, or Myeloma Unknown status NCT00003885 Phase 2 arsenic trioxide
35 External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
36 Lenalidomide in HTLV-1 Adult T-Cell Leukemia Completed NCT01274533 Phase 2 Lenalidomide
37 Phase II Study of KW-0761 in Subjects With CCR4-positive Adult T-cell Leukemia-lymphoma Completed NCT00920790 Phase 2
38 Campath-1H for Treating Adult T-Cell Leukemia/Lymphoma Completed NCT00061048 Phase 2
39 Repeat-Dose of Forodesine Hydrochloride (BCX-1777) Infusion in Patients With Advanced T-Cell Leukemia Completed NCT00095381 Phase 2 forodesine hydrochloride (BCX-1777)
40 Phase II Study of the Efficacy and Toxicity of Ontak(Registered Trademark) (Denileukin Diftitox) in the Therapy of Adult T-Cell Leukemia Completed NCT00117845 Phase 2
41 A Phase II Study Of Imtox-25 In Adults With Refractory/Relapsed Cd25 Positive Adult T Cell Leukemia/Lymphoma Completed NCT01378871 Phase 2 IMTOX-25
42 Multicenter, Randomized, Open-label, Parallel-group Study to Compare mLSG15 + KW-0761 to mLSG15 Completed NCT01173887 Phase 2 VCAP/AMP/VECP(mLSG15)
43 Anti-Tac for Treatment of Leukemia Completed NCT00001941 Phase 1, Phase 2
44 EPOCH Chemotherapy and Bortezomib for Associated T-Cell Leukemia Lymphoma Completed NCT01000285 Phase 1, Phase 2 Bortezomib;Etoposide;Vincristine;Doxorubicin;Prednisone;Cyclophosphamide;Raltegravir
45 RAD001 in Relapsed or Refractory AML, ALL, CML in Blastic-Phase, Agnogenic Myeloid Metaplasia, CLL, T-Cell Leukemia, or Mantle Cell Lymphoma Completed NCT00081874 Phase 1, Phase 2 RAD001
46 Combination Chemotherapy Followed By Antiviral Therapy and Interferon Alfa in Treating Patients With HTLV-1-Related Adult T-Cell Leukemia/Lymphoma Completed NCT00041327 Phase 2 Etoposide;cyclophosphamide;doxorubicin hydrochloride;lamivudine;prednisone;vincristine sulfate;zidovudine
47 Study of Intravenous BCX-1777 in Relapsed or Refractory Aggressive T-Cell Leukemias or Lymphomas Completed NCT00035022 Phase 1, Phase 2 BCX-1777
48 Monoclonal Antibody Therapy in Treating Patients With Leukemia Completed NCT00019227 Phase 1, Phase 2 pentetic acid calcium
49 Acute Myeloid Leukemia T Cell Depletion to Improve Transplants in Adults With Acute Myeloid Leukemia (BMT CTN 0303) Completed NCT00201240 Phase 2
50 Treatment of Relapsed T-Cell Acute Lymphoblastic Leukemia or T-Lymphoblastic Lymphoma With MabCampath Completed NCT00199030 Phase 2 Alemtuzumab (MabCampath);Cladribine

Search NIH Clinical Center for T-Cell Leukemia

Cochrane evidence based reviews: leukemia, t-cell

Genetic Tests for T-Cell Leukemia

Anatomical Context for T-Cell Leukemia

MalaCards organs/tissues related to T-Cell Leukemia:

38
T Cells, Bone, Bone Marrow, Liver, Myeloid, Colon, Skin

Publications for T-Cell Leukemia

Articles related to T-Cell Leukemia:

(show top 50) (show all 1912)
# Title Authors Year
1
Indolent, waxing and waning cutaneous presentation of HTLV-1-associated adult T-cell leukemia/lymphoma in an HIV-1-positive patient. ( 29094771 )
2018
2
Emerging therapeutic targets in myeloproliferative neoplasms and peripheral T-cell leukemia and lymphomas. ( 29148847 )
2018
3
A Review of New Findings in Adult T-cell Leukemia-Lymphoma: A Focus on Current and Emerging Treatment Strategies. ( 29411267 )
2018
4
Adult T-cell leukemia/lymphoma can be indistinguishable from other more common T-cell lymphomas. The University of Miami experience with a large cohort of cases. ( 29449683 )
2018
5
Successful treatment of post-transplant relapsed adult T cell leukemia after cord blood transplantation with low-dose, short-term lenalidomide. ( 29382244 )
2018
6
Adult T cell leukemia/lymphoma with different pathological features in each tumor site. ( 29427186 )
2018
7
Erratum for Narulla et al., "Positive and Negative Regulation of Type I Interferons by the Human T Cell Leukemia Virus Antisense Protein HBZ". ( 29295960 )
2018
8
Control of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Infection by Eliminating Envelope Protein-Positive Cells with Recombinant Vesicular Stomatitis Viruses Encoding HTLV-1 Primary Receptor. ( 29212930 )
2018
9
Expression pattern of immunosurveillance-related antigen in adult T-cell leukemia/lymphoma. ( 29297942 )
2018
10
Outcomes of patients with relapsed aggressive adult T-cell leukemia-lymphoma: clinical effectiveness of anti-CCR4 antibody and allogeneic hematopoietic stem cell transplantation. ( 29371324 )
2018
11
Role of up-front allogeneic hematopoietic stem cell transplantation for patients with aggressive adult T-cell leukemia-lymphoma: a decision analysis. ( 29371687 )
2018
12
Adult T-Cell Leukemia/Lymphoma With Primary Lacrimal Gland Involvement. ( 29068833 )
2018
13
Syngeneic hematopoietic stem cell transplantation from HTLV-1 seropositive twin for adult T-cell leukemia-lymphoma. ( 29358601 )
2018
14
Hepatic leukemia-associated macrophages exhibit a pro-inflammatory phenotype in Notch1-induced acute T cell leukemia. ( 29030004 )
2018
15
Retraction notice to Inhibition of proliferation and induction of apoptosis by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide in adult T-cell leukemia cells. ( 29273235 )
2018
16
Deep sequencing of the T cell receptor visualizes reconstitution of T cell immunity in mogamulizumab-treated adult T cell leukemia. ( 29399406 )
2018
17
Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma. ( 29084771 )
2018
18
Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T-cell leukemia. ( 29077243 )
2018
19
Development of sugar chain-binding single chain variable fragment antibody to adult T-cell leukemia cells using glyco-nanotechnology and phage display method. ( 29351623 )
2018
20
Role of Integrin Signaling Activation on the Development of Human T-Cell Leukemia VIrus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis: Its Relationship to HTLV-1-infected CD4+ T Cell Transmigrating Activity into the Tissues. ( 29400072 )
2018
21
Acute myelitis resembling human T-lymphotropic virus type 1-associated myelopathy presenting as high-signal-intensity long cord lesions on T2-weighted magnetic resonance images combined with lymphoma-type adult T-cell leukemia/lymphoma. ( 27817856 )
2017
22
Adult T cell leukemia aggressivenness correlates with loss of both 5-hydroxymethylcytosine and TET2 expression. ( 28881727 )
2017
23
Expression and significance of Pim-3 kinase in adult T-cell leukemia. ( 28833639 )
2017
24
Failure to prevent human T-cell leukemia virus type 1 mother-to-child transmission in Japan. ( 28211219 )
2017
25
Galectin-9 as a Predictive Marker for the Onset of Immune-Related Adverse Effects Associated with Anti-CCR4 MoAb Therapy in Patients with Adult T Cell Leukemia. ( 28321034 )
2017
26
Genetic alterations in adult T-cell leukemia/lymphoma. ( 28627735 )
2017
27
Mogamulizumab for the treatment of relapsed or refractory adult T-cell leukemia-lymphoma. ( 28756726 )
2017
28
Perturbation of Human T-Cell Leukemia Virus Type 1 Particle Morphology by Differential Gag Co-Packaging. ( 28753950 )
2017
29
Positive and Negative Regulation of Type I Interferons by the Human T Cell Leukemia Virus Antisense Protein HBZ. ( 28768861 )
2017
30
Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells. ( 28075522 )
2017
31
Welder's pulmonary hemosiderosis associated with systemic iron overload following exacerbation of acute adult T-cell leukemia/lymphoma. ( 28883221 )
2017
32
Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. ( 29186194 )
2017
33
Generalized rash and lymphocytosis as clinical onset adult T-cell leukemia/lymphoma. ( 28645687 )
2017
34
Detection of human T-cell lymphotropic virus type I-specific cytotoxic T-cells may predict treatment responses in adult T-cell leukemia/lymphoma patients. ( 28656327 )
2017
35
Cyclin-dependent kinase 9 is a novel specific molecular target in adult T-cell leukemia/lymphoma. ( 28646117 )
2017
36
Unilateral conjunctival infiltration of Adult T-cell leukemia/lymphoma. Case report and literature review. ( 29279551 )
2017
37
Suppression of protein tyrosine phosphatase PTPN22 gene induces apoptosis in T-cell leukemia cell line (Jurkat) through the AKT and ERK pathways. ( 27936393 )
2017
38
Human T Cell Leukemia Virus Type 1 and Eye Diseases. ( 28263674 )
2017
39
HLA-DMB restricts human T-cell leukemia virus type-1 (HTLV-1) protein expression via regulation of ATG7 acetylation. ( 29089548 )
2017
40
RNA stability regulates human T cell leukemia virus type 1 gene expression in chronically-infected CD4 T cells. ( 28478312 )
2017
41
Flow cytometric-based protocols for assessing anti-MT-2 IgG1 reactivity: High-dimensional data handling to define predictors for clinical follow-up of Human T-cell Leukemia virus type-1 infection. ( 28212879 )
2017
42
Development of a complete human IgG monoclonal antibody to transferrin receptor 1 targeted for adult T-cell leukemia/lymphoma. ( 28189691 )
2017
43
The T-cell leukemia related rpl10-R98S mutant traps the 60S export adapter Nmd3 in the ribosomal P site in yeast. ( 28715419 )
2017
44
Epigenetic Silencing of the Human 18a88kDa Translocator Protein in a T Cell Leukemia Cell Line. ( 28004979 )
2017
45
Epidemiological and clinical features of adult T-cell leukemia-lymphoma in Japan, 2010-2011: A nationwide survey. ( 28905463 )
2017
46
Evaluation of INOS, ICAM-1, and VCAM-1 gene expression: A study of adult T cell leukemia malignancy associated with HTLV-1. ( 28110427 )
2017
47
Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell Leukemia/Lymphoma by Suppressing the ERK1/2 Pathway. ( 28785594 )
2017
48
The T-cell leukemia associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling. ( 28744013 )
2017
49
Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. ( 28811663 )
2017
50
Mogamulizumab for relapsed adult T-cell leukemia-lymphoma: Updated follow-up analysis of phase I and II studies. ( 28776876 )
2017

Variations for T-Cell Leukemia

Expression for T-Cell Leukemia

Search GEO for disease gene expression data for T-Cell Leukemia.

Pathways for T-Cell Leukemia

Pathways related to T-Cell Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.48 CDK6 CREB1 CRTC2 TCL1A TCL1B
2
Show member pathways
11.37 CREB1 CRTC2 SLC2A1
3 11.14 CREB1 CRTC2 SLC2A1
4 10.38 TLX1 TLX2 TLX3

GO Terms for T-Cell Leukemia

Biological processes related to T-Cell Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.73 GLI2 TAL1 TCL1A TLX1 TLX2 TLX3
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.17 CREB1 CRTC2 GLI2 LMO1 TAL1 TLX1
3 positive regulation of protein oligomerization GO:0032461 9.16 PMAIP1 TCL1A
4 generation of neurons GO:0048699 8.96 CDK6 TAL1

Molecular functions related to T-Cell Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.1 CREB1 FOXN2 GLI2 TLX1 TLX2 TLX3
2 protein serine/threonine kinase activator activity GO:0043539 8.96 TCL1A TCL1B

Sources for T-Cell Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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