MCID: TCL004
MIFTS: 50

T-Cell Leukemia malady

Summaries for T-Cell Leukemia

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64Wikipedia, 33MalaCards
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Wikipedia:64 T-cell leukemia describes several different types of lymphoid leukemia which affect T cells. more...

MalaCards: T-Cell Leukemia, also known as leukemia, t-cell, is related to peripheral t-cell lymphoma and follicular lymphoma. An important gene associated with T-Cell Leukemia is TAL1 (T-cell acute lymphocytic leukemia 1), and among its related pathways is Transcriptional misregulation in cancer. The compounds [alcl] and cobalt chloride have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node.

Aliases & Classifications for T-Cell Leukemia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH
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Aliases & Descriptions:

t-cell leukemia 8 10
leukemia, t-cell 61
leukemia t-cell 45


External Ids:

Disease Ontology8 DOID:715
MeSH35 D015458

Related Diseases for T-Cell Leukemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to T-Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1peripheral t-cell lymphoma30.5BCL3, MCL1, TCL1A
2follicular lymphoma30.4MCL1, BCL3, TCL1A
3precursor t-cell acute lymphoblastic leukemia30.3TAL1, MCL1, TLX3, CD7, TLX1
4b-cell lymphomas30.0TCL1A, BCL3, MCL1
5lymphoblastic lymphoma30.0TAL1, CD7
6adult t-cell leukemia11.3
7adult lymphoma11.3
8leukemia/lymphoma, t-cell11.2
9acute leukemia10.9
10spastic paraparesis10.8
11tropical spastic paraparesis10.8
12acute t cell leukemia10.8
13hypercalcemia10.7
14hematopoietic stem cell transplantation10.7
15leukemia, t-cell, chronic10.5
16adult syndrome10.5
17human t-cell leukemia virus type 110.5
18human t-cell leukemia virus type 210.5
19bone lymphoma10.5
20lymphoid leukemia10.4
21hepatitis c10.4
22central nervous system leukemia10.4
23mycosis fungoides10.4
24colon lymphoma10.4
25human t-cell leukemia virus type 310.4
26plasma cell leukemia10.4
27pediatric t-cell leukemia10.4
28hepatitis c virus10.4
29strongyloidiasis10.3
30gastric lymphoma10.3
31arthritis10.3
32graft versus host disease10.3
33norwegian scabies10.3
34acute pancreatitis10.3
35natural killer cell leukemia10.3
36null-cell leukemia10.3
37follicular mucinosis10.3
38orbit lymphoma10.3
39anaplastic large cell lymphoma10.3
40arthropathy10.3
41uveitis10.3
42t-cell prolymphocytic leukemia10.3
43acute liver failure10.2
44central nervous system lymphoma10.2
45ataxia telangiectasia10.2
46testicular leukemia10.2
47acute myeloid leukemia10.2
48inclusion body myositis10.2
49t-cell adult acute lymphocytic leukemia10.2
50pancytopenia10.2

Graphical network of the top 20 diseases related to T-Cell Leukemia:



Diseases related to t-cell leukemia

Clinical Features for T-Cell Leukemia

Drugs & Therapeutics for T-Cell Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for T-Cell Leukemia

Drug clinical trials:

Search ClinicalTrials for T-Cell Leukemia

Search NIH Clinical Center for T-Cell Leukemia

Search CenterWatch for T-Cell Leukemia

Genetic Tests for T-Cell Leukemia

Anatomical Context for T-Cell Leukemia

Sources:
33MalaCards
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MalaCards organs/tissues related to T-Cell Leukemia:

33
Bone marrow, Whole blood, Lymph node, Spleen, Thymus, Brain, Retina, Spinal cord, Smooth muscle, Skeletal muscle, Small intestine, Colon, Adipocyte, Kidney, Liver, Lung, Pancreas, Thyroid, Adrenal gland, Breast, Skin, Uterus, Prostate, Testis, Tonsil, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Cardiac myocytes, Atrioventricular node, Tongue, Fetal liver, Fetal lung, Fetal thyroid, Pituitary, Testis germ, Testis leydig

Animal Models for T-Cell Leukemia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for T-Cell Leukemia

Sources:
51PubMed
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Articles related to T-Cell Leukemia:

(show top 50)    (show all 4159)
idTitleAuthorsYear
1
Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors. (23975177)
2014
2
Allogeneic hematopoietic stem cell transplantation for patients with acute leukemia. (23997525)
2013
3
Increased PRAME-specific CTL killing of acute myeloid leukemia cells by either a novel histone deacetylase inhibitor chidamide alone or combined treatment with decitabine. (23940586)
2013
4
Efficacy of acute myeloid leukemia therapy without stem-cell transplantation in a child with blastic plasmacytoid dendritic cell neoplasm. (23449596)
2013
5
SPARC expression in CML is associated to imatinib treatment and to inhibition of leukemia cell proliferation. (23383963)
2013
6
Hematopoietic stem cell transplantation in children with acute leukemia: similar outcomes in recipients of umbilical cord blood versus marrow or peripheral blood stem cells from related or unrelated donors. (22474464)
2012
7
Fifty years of hairy cell leukemia treatments. (21599600)
2011
8
Hematopoietic stem cell transplantation in acute promyelocytic leukemia, experience in Iran. (21888457)
2011
9
The leukemia associated ETO nuclear repressor gene is regulated by the GATA-1 transcription factor in erythroid/megakaryocytic cells. (20487545)
2010
10
JAK2V617F mutation persists in blasts and mature cells of transformed JAK2V617F-positive-myeloproliferative neoplasia: a European Leukemia Net (ENL) study. (20425802)
2010
11
Therapeutic targeting of NOTCH1 signaling in T-cell acute lymphoblastic leukemia. (19778842)
2009
12
Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia. (19641190)
2009
13
Hemophagocytic lymphohistiocytosis during maintenance treatment of precursor B-cell acute lymphoblastic leukemia. (19043809)
2008
14
FDA drug approval summary: alemtuzumab as single-agent treatment for B-cell chronic lymphocytic leukemia. (18305062)
2008
15
Erythema multiforme-like lesions associated with lesional infiltration of tumor cells occurring with adult T-cell lymphoma/leukemia. (18377607)
2008
16
Specific inhibition of basal mitogen-activated protein kinases and phosphatidylinositol 3 kinase activities in leukemia cells: a possible therapeutic role for the kinase inhibitors. (17949889)
2008
17
Identification of somatic hypermutations in the TP53 gene in B-cell chronic lymphocytic leukemia. (17920683)
2008
18
Development of adult T-cell leukemia in donor-derived human T-cell leukemia virus type I-infected T cells after allogeneic bone marrow transplantation. (17443225)
2007
19
T-cell acute lymphoblastic leukemia in a child with ataxia-telangiectasia: case report. (17921854)
2007
20
Cyclin D2 dysregulation by chromosomal translocations to TCR loci in T-cell acute lymphoblastic leukemias. (16270038)
2006
21
Relationship between autoimmune phenomena and disease stage and therapy in B-cell chronic lymphocytic leukemia. (17145607)
2006
22
The anti-tumoral effect of PI3K inhibitor and MEK inhibitor combined with STI571 on chronic myeloid leukemia cells in a bone marrow stromal cell co-culture system]. (17094575)
2006
23
Reduced frequency, diversity, and function of human T cell leukemia virus type 1-specific CD8+ T cell in adult T cell leukemia patients. (17015761)
2006
24
Human T-cell leukemia virus type 1 tax dysregulates beta-catenin signaling. (16920823)
2006
25
An in vitro dendritic cells-induced T lymphocytes cytotoxicity study activated by thaw frozen K562 lysates antigen in chronic myeloid leukemia]. (17327003)
2006
26
Immune recovery after low-dose Campath therapy in a group of pretreated patients affected by B-cell chronic lymphocytic leukemia. (15496971)
2005
27
PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein is essential for the interleukin 2 independent growth induction of a T-cell line. (16042787)
2005
28
IFN-alpha promotes the rapid differentiation of monocytes from patients with chronic myeloid leukemia into activated dendritic cells tuned to undergo full maturation after LPS treatment. (14525781)
2004
29
Alkylating agents and nucleoside analogues in the treatment of B cell chronic lymphocytic leukemia. (12040433)
2002
30
Rituximab therapy of patients with B-cell chronic lymphocytic leukemia. (11520778)
2001
31
Allogeneic stem cell transplantation for acute lymphocytic leukemia in adults. (11253611)
2001
32
Prolymphocytic leukemia or prolymphocytic transformation of mantle cell lymphoma. (11710698)
2001
33
TALE homeoproteins as HOX11-interacting partners in T-cell leukemia. (11342305)
2000
34
Prolonged interferon-alpha-2b treatment of hairy cell leukemia patients. (10863983)
2000
35
Treatment of hairy cell leukemia-variant with cladribine. (10706459)
1999
36
The Y-S-L-I tyrosine-based motif in the cytoplasmic domain of the human T-cell leukemia virus type 1 envelope is essential for cell-to-cell transmission. (10516080)
1999
37
The effect of cytokines on the activation of T cells induced by B7-1-transfected leukemia cells]. (11243110)
1998
38
Chronic lymphocytic leukemia B cells are resistant to the apoptotic effects of transforming growth factor-beta. (9028325)
1997
39
Loss of functional cell surface transforming growth factor beta (TGF-beta) type 1 receptor correlates with insensitivity to TGF-beta in chronic lymphocytic leukemia. (9159168)
1997
40
Bryostatin 1 induces ubiquitin COOH-terminal hydrolase in acute lymphoblastic leukemia cells. (9252784)
1996
41
Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells. (8950193)
1996
42
Characterization of hepatitis C virus replication in cloned cells obtained from a human T-cell leukemia virus type 1-infected cell line, MT-2. (8794370)
1996
43
Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I. (7862633)
1995
44
Phorbol regulation of topoisomerases I and II in human leukemia cells. Studies in an additional cell pair sensitive or resistant to phorbol-induced differentiation. (8304982)
1994
45
Human T cell leukemia virus type 1 (HTLV-1) antibodies in healthy populations and renal transplanted patients in the north-east of Brazil. (7968679)
1994
46
Efficacy and toxicity of 9-beta-D-arabinofuranosylguanine (araG) as an agent to purge malignant T cells from murine bone marrow: application to an in vivo T-leukemia model. (8350627)
1993
47
Interleukin-2 with or without lymphokine-activated killer cells as consolidative immunotherapy after autologous bone marrow transplantation for acute myelogenous leukemia. (8401364)
1993
48
Effects of tumor necrosis factor alpha, interferon alpha and interferon gamma on non-lymphoid leukemia cell lines: growth inhibition, differentiation induction and drug sensitivity modulation. (1511460)
1992
49
Sexual transmission of human T-cell leukemia virus type I associated with the presence of anti-Tax antibody. (1996321)
1991
50
Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene. (1886719)
1991

Genetic Variations for T-Cell Leukemia

Expression for genes affiliated with T-Cell Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with T-Cell Leukemia

Search GEO for disease gene expression data for T-Cell Leukemia.

Pathways for genes affiliated with T-Cell Leukemia

Sources:
30KEGG
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Pathways related to T-Cell Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9PBX3, TLX1, TLX3

Compounds for genes affiliated with T-Cell Leukemia

Sources:
45Novoseek
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Compounds related to T-Cell Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1[alcl]4510.8BCL3, MCL1
2cobalt chloride4510.5SLC2A1, MCL1

GO Terms for genes affiliated with T-Cell Leukemia

Sources:
16Gene Ontology
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Cellular components related to T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563412.2BCL3, TLX3, TLX1, FOXN2, MCL1, TAL1

Biological processes related to T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spleen developmentGO:04853610.8BCL3, TLX1
2regulation of respiratory gaseous exchange by neurological system processGO:00208710.5PBX3, TLX3

Molecular functions related to T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:00370011.6BCL3, TLX2, TLX3, TLX1, FOXN2, TAL1
2sequence-specific DNA bindingGO:04356511.6TLX3, TLX1, FOXN2, PBX3, PBX4, PBX2

Products for genes affiliated with T-Cell Leukemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for T-Cell Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet