MCID: TCL004
MIFTS: 49

T-Cell Leukemia malady

Summaries for T-Cell Leukemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 T-cell leukemia describes several different types of lymphoid leukemia which affect T cells. more...

MalaCards: T-Cell Leukemia, also known as leukemia, t-cell, is related to leukemia and lymphoblastic leukemia. An important gene associated with T-Cell Leukemia is TAL1 (T-cell acute lymphocytic leukemia 1), and among its related pathways is Transcriptional misregulation in cancer. The compounds [alcl] and cobalt chloride have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and myeloid.

Aliases & Classifications for T-Cell Leukemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH
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Aliases & Descriptions:

t-cell leukemia 8 10
leukemia, t-cell 60
leukemia t-cell 44


External Ids:

Disease Ontology8 DOID:715
MeSH34 D015458

Related Diseases for T-Cell Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Acute T Cell Leukemia family:

Adult T-Cell Leukemia t-cell leukemia
Leukemia, B-Cell, Chronic Leukemia, T-Cell, Chronic
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3

Diseases related to T-Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.5BCL3, TLX3, TLX1, HTLVR, CD7, MCL1
2lymphoblastic leukemia30.7TLX1
3hodgkin's lymphoma30.5BCL3, TCL1A, MCL1
4chronic lymphocytic leukemia30.5MCL1, TCL1A, BCL3
5adult t-cell leukemia11.5
6adult lymphoma11.3
7acute t cell leukemia10.9
8acute leukemia10.9
9tropical spastic paraparesis10.8
10hypercalcemia10.6
11cutaneous t cell lymphoma10.6
12adult syndrome10.5
13hepatitis10.5
14bone lymphoma10.5
15lymphoid leukemia10.4
16central nervous system leukemia10.4
17mycosis fungoides10.4
18monocytic leukemia10.4
19scabies10.4
20t cell deficiency10.4
21myeloid leukemia10.4
22pneumonia10.4
23prolymphocytic leukemia10.4
24human t-cell leukemia virus type 110.4
25human t-cell leukemia virus type 210.4
26human t-cell leukemia virus type 310.4
27strongyloidiasis10.3
28hepatitis c10.3
29gastric lymphoma10.3
30arthritis10.3
31childhood leukemia10.3
32dermatitis10.3
33eosinophilia10.3
34herpes simplex10.3
35retinitis10.3
36pediatric t-cell leukemia10.3
37graft versus host disease10.3
38norwegian scabies10.3
39acute pancreatitis10.3
40natural killer cell leukemia10.3
41follicular mucinosis10.3
42orbit lymphoma10.3
43anaplastic large cell lymphoma10.3
44t-cell large granular lymphocyte leukemia10.3
45hepatitis a10.3
46arthropathy10.3
47meningitis10.3
48neuropathy10.3
49pancreatitis10.3
50uveitis10.3

Graphical network of the top 20 diseases related to T-Cell Leukemia:



Diseases related to t-cell leukemia

Clinical Features for T-Cell Leukemia

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Drugs & Therapeutics for T-Cell Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for T-Cell Leukemia

Drug clinical trials:

Search ClinicalTrials for T-Cell Leukemia

Search NIH Clinical Center for T-Cell Leukemia

Search CenterWatch for T-Cell Leukemia

Genetic Tests for T-Cell Leukemia

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Anatomical Context for T-Cell Leukemia

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32MalaCards
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MalaCards organs/tissues related to T-Cell Leukemia:

32
T cells, B cells, Myeloid, Bone, Bone marrow, Skin, Lung, Monocytes, Liver, Endothelial, Lymph node, Breast, Colon, Nk cells, Brain, Testes, Pituitary, Spleen, Thymus, Retina, Thyroid, Spinal cord, Heart, Testis, Eye, Prostate

Animal Models for T-Cell Leukemia or affiliated genes

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Publications for T-Cell Leukemia

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50PubMed
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Articles related to T-Cell Leukemia:

(show top 50)    (show all 2523)
idTitleAuthorsYear
1
T-cell prolymphocytic leukemia. (23382603)
2013
2
Occult T Cell Acute Lymphoblastic Leukemia Presenting as Obstructive Pancreatitis. (24157447)
2013
3
BCL11B, FLT3, NOTCH1 and FBXW7 mutation status in T-cell acute lymphoblastic leukemia patients. (23040356)
2013
4
p53 dysfunction precedes the activation of nuclear factor-I_B during disease progression in mice expressing Tax, a human T-cell leukemia virus type 1 oncoprotein. (23633516)
2013
5
Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia. (23079656)
2012
6
Resistant and disseminated Strongyloides stercoralis infection in a young patient with adult T-cell leukemia/lymphoma. (23323073)
2012
7
Immunopathogenesis of human T-cell leukemia virus type-1-associated myelopathy/tropical spastic paraparesis: recent perspectives. (23198155)
2012
8
Folliculotropic adult T-cell leukemia/lymphoma: a possibly under-recognized variant. (22441372)
2012
9
Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. (22897851)
2012
10
Intracellular reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cells. (21455214)
2011
11
Intra- and inter-laboratory variability in human T-cell leukemia virus type-1 proviral load quantification using real-time polymerase chain reaction assays: a multi-center study. (20874852)
2010
12
MICA polymorphism identified by whole genome array associated with NKG2D-mediated cytotoxicity in T-cell large granular lymphocyte leukemia. (20460636)
2010
13
Adult T-Cell Leukemia/Lymphoma with CLL-Like Morphology-A Case Report. (20368783)
2010
14
Identification of cancer stem cells in a Tax-transgenic (Tax-Tg) mouse model of adult T-cell leukemia/lymphoma. (19584402)
2009
15
Extranodal involvement of the head and neck region in adult T-cell leukemia/lymphoma: rare, but relevant. (19235009)
2009
16
Basal c-Jun NH2-terminal protein kinase activity is essential for survival and proliferation of T-cell acute lymphoblastic leukemia cells. (19996270)
2009
17
Identification of a novel point mutation in ENT1 that confers resistance to Ara-C in human T cell leukemia CCRF-CEM cells. (19116148)
2009
18
Development of Notch-dependent T-cell leukemia by deregulated Rap1 signaling. (18180377)
2008
19
Human T-cell leukemia virus type 1 blunts signaling by interferon alpha. (18234266)
2008
20
FBXW7 mutation in adult T-cell and B-cell acute lymphocytic leukemias. (18485478)
2008
21
T-cell acute lymphoblastic leukemia in a child with ataxia-telangiectasia: case report. (17921854)
2007
22
Does the HBZ gene represent a new potential target for the treatment of adult T-cell leukemia? (18027202)
2007
23
The role of LMO2 in development and in T cell leukemia after chromosomal translocation or retroviral insertion. (16260184)
2006
24
T-cell prolymphocytic leukemia: an aggressive T cell malignancy with frequent cutaneous tropism. (16908353)
2006
25
T cell receptor gene recombination in human T-cell leukemia cell line jurkat]. (17059760)
2006
26
Lung infiltration of adult T-cell leukemia cells following the administration of arsenic trioxide. Lung infiltration of ATL by AS(2)O(3). (16165312)
2006
27
Current views in HTLV-I-associated adult T-cell leukemia/lymphoma. (15726602)
2005
28
In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins. (15958635)
2005
29
Both the PPPY and PTAP motifs are involved in human T-cell leukemia virus type 1 particle release. (14722305)
2004
30
Clinical relevance of survivin as a biomarker in neoplasms, especially in adult T-cell leukemias and acute leukemias. (15293568)
2004
31
CD25 monoclonal antibody for GVHD prophylaxis in non-T-cell depleted haploidentical bone marrow transplantation for treatment of childhood leukemia]. (15157394)
2004
32
T-cell prolymphocytic leukemia with autoimmune manifestations in Nijmegen breakage syndrome. (12845481)
2003
33
Thymic epithelial cells promote survival of human T-cell acute lymphoblastic leukemia blasts: the role of interleukin-7. (14607751)
2003
34
A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein. (14612415)
2003
35
Acute pancreatitis induced by diffuse pancreatic invasion of adult T-cell leukemia/lymphoma cells. (14627344)
2003
36
Identification and characterisation of clonal incomplete T-cell-receptor Vdelta2-Ddelta3/Ddelta2-Ddelta3 rearrangements by denaturing high-performance liquid chromatography and subsequent fragment collection: implications for minimal residual disease monitoring in childhood acute lymphoblastic leukemia. (12860036)
2003
37
Acetylation of nucleosomal histones by p300 facilitates transcription from tax-responsive human T-cell leukemia virus type 1 chromatin template. (12052856)
2002
38
Correlation of major histocompatibility complex class I downregulation with resistance of human T-cell leukemia virus type 1-infected T cells to cytotoxic T-lymphocyte killing in a rat model. (12072501)
2002
39
A complex pattern of recurrent chromosomal losses and gains in T-cell prolymphocytic leukemia. (11391795)
2001
40
Expression of functional lung resistance--related protein predicts poor outcome in adult T-cell leukemia. (11493465)
2001
41
HTLV-I Tax related dysfunction of cell cycle regulators and oncogenesis of adult T cell leukemia. (11426548)
2001
42
The role of TCL1 in human T-cell leukemia. (11607815)
2001
43
Defective DNA repair in cells with human T-cell leukemia/bovine leukemia viruses: role of tax gene. (10359545)
1999
44
Neutropenia associated with T-cell large granular lymphocyte leukemia: long-term response to cyclosporine therapy despite persistence of abnormal cells. (9558395)
1998
45
A comparative study of aspartyl and cysteine proteinases and their inhibitors in human B- and T-cell leukemias]. (8079445)
1994
46
A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. (8197160)
1994
47
Development of a sensitive two-site immunoradiometric assay for parathyroid hormone-related peptide: evidence for elevated levels in plasma from patients with adult T-cell leukemia/lymphoma and B-cell lymphoma. (7962324)
1994
48
Occurrence of T-cell lymphoma in a patient with Philadelphia chromosome-positive chronic myelogenous leukemia with rearrangements of BCR and TCR-beta genes in the lymph nodes. (8438886)
1993
49
Type I human T cell leukemia virus tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway. (1832173)
1991
50
Geographical distribution of subjects seropositive for human T-cell leukemia virus type 1 in Papua New Guinea. (2125990)
1990

Genetic Variations for T-Cell Leukemia

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Expression for genes affiliated with T-Cell Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with T-Cell Leukemia

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Pathways for genes affiliated with T-Cell Leukemia

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29KEGG
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Pathways related to T-Cell Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9PBX3, TLX1, TLX3

Compounds for genes affiliated with T-Cell Leukemia

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44Novoseek
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Compounds related to T-Cell Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1[alcl]4410.8BCL3, MCL1
2cobalt chloride4410.5SLC2A1, MCL1

GO Terms for genes affiliated with T-Cell Leukemia

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16Gene Ontology
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Cellular components related to T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563412.2BCL3, TLX3, TLX1, FOXN2, MCL1, TAL1

Biological processes related to T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spleen developmentGO:04853610.8BCL3, TLX1
2regulation of respiratory gaseous exchange by neurological system processGO:00208710.5PBX3, TLX3

Molecular functions related to T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:00370011.6BCL3, TLX2, TLX3, TLX1, FOXN2, TAL1
2sequence-specific DNA bindingGO:04356511.6TLX3, TLX1, FOXN2, PBX3, PBX4, PBX2

Products for genes affiliated with T-Cell Leukemia

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Sources for T-Cell Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet