MCID: TCL004
MIFTS: 49

T-Cell Leukemia malady

Summaries for T-Cell Leukemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 T-cell leukemia describes several different types of lymphoid leukemia which affect T cells. more...

MalaCards: T-Cell Leukemia, also known as leukemia, t-cell, is related to leukemia and lymphoblastic leukemia. An important gene associated with T-Cell Leukemia is TAL1 (T-cell acute lymphocytic leukemia 1), and among its related pathways is Transcriptional misregulation in cancer. The compounds [alcl] and cobalt chloride have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and myeloid.

Aliases & Classifications for T-Cell Leukemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH
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Aliases & Descriptions:

t-cell leukemia 8 10
leukemia, t-cell 60
leukemia t-cell 44


External Ids:

Disease Ontology8 DOID:715
MeSH34 D015458

Related Diseases for T-Cell Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Acute T Cell Leukemia family:

Adult T-Cell Leukemia t-cell leukemia
Leukemia, B-Cell, Chronic Leukemia, T-Cell, Chronic
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3

Diseases related to T-Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.5BCL3, TLX3, TLX1, HTLVR, CD7, MCL1
2lymphoblastic leukemia30.7TLX1
3hodgkin's lymphoma30.5BCL3, TCL1A, MCL1
4chronic lymphocytic leukemia30.5MCL1, TCL1A, BCL3
5adult t-cell leukemia11.5
6adult lymphoma11.3
7acute t cell leukemia10.9
8acute leukemia10.9
9tropical spastic paraparesis10.8
10hypercalcemia10.6
11cutaneous t cell lymphoma10.6
12adult syndrome10.5
13hepatitis10.5
14bone lymphoma10.5
15lymphoid leukemia10.4
16central nervous system leukemia10.4
17mycosis fungoides10.4
18monocytic leukemia10.4
19scabies10.4
20t cell deficiency10.4
21myeloid leukemia10.4
22pneumonia10.4
23prolymphocytic leukemia10.4
24human t-cell leukemia virus type 110.4
25human t-cell leukemia virus type 210.4
26human t-cell leukemia virus type 310.4
27strongyloidiasis10.3
28hepatitis c10.3
29gastric lymphoma10.3
30arthritis10.3
31childhood leukemia10.3
32dermatitis10.3
33eosinophilia10.3
34herpes simplex10.3
35retinitis10.3
36pediatric t-cell leukemia10.3
37graft versus host disease10.3
38norwegian scabies10.3
39acute pancreatitis10.3
40natural killer cell leukemia10.3
41follicular mucinosis10.3
42orbit lymphoma10.3
43anaplastic large cell lymphoma10.3
44t-cell large granular lymphocyte leukemia10.3
45hepatitis a10.3
46arthropathy10.3
47meningitis10.3
48neuropathy10.3
49pancreatitis10.3
50uveitis10.3

Graphical network of the top 20 diseases related to T-Cell Leukemia:



Diseases related to t-cell leukemia

Clinical Features for T-Cell Leukemia

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Drugs & Therapeutics for T-Cell Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for T-Cell Leukemia

Drug clinical trials:

Search ClinicalTrials for T-Cell Leukemia

Search NIH Clinical Center for T-Cell Leukemia

Search CenterWatch for T-Cell Leukemia

Genetic Tests for T-Cell Leukemia

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Anatomical Context for T-Cell Leukemia

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32MalaCards
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MalaCards organs/tissues related to T-Cell Leukemia:

32
T cells, B cells, Myeloid, Bone, Bone marrow, Skin, Lung, Monocytes, Liver, Endothelial, Lymph node, Breast, Nk cells, Colon, Brain, Pituitary, Retina, Thyroid, Thymus, Spleen, Testes, Testis, Heart, Eye, Spinal cord, Prostate

Animal Models for T-Cell Leukemia or affiliated genes

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Publications for T-Cell Leukemia

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50PubMed
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Articles related to T-Cell Leukemia:

(show top 50)    (show all 2523)
idTitleAuthorsYear
1
The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL. (23341344)
2013
2
Natural OX40L expressed on human T cell leukemia virus type-I-immortalized T cell lines interferes with infection of activated peripheral blood mononuclear cells by CCR5-utilizing human immunodeficiency virus. (24238037)
2013
3
The PD-1/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia. (23300177)
2013
4
T-cell acute lymphoblastic leukemia/lymphoma with inversion(3)(q21q26). (23521817)
2013
5
Unusual scalp crusted scabies in an adult T-cell leukemia/lymphoma patient. (21235380)
2011
6
Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemia. (19829307)
2010
7
Complete remission in two cases of adult T-cell leukemia/lymphoma treated with hyper-CVAD: a case report and review of the literature. (21156467)
2010
8
Development of secondary T-cell acute lymphoblastic leukemia in a child with hemophagocytic lymphohistiocytosis. (20589661)
2010
9
Mouse models of human T lymphotropic virus type-1-associated adult T-cell leukemia/lymphoma. (20442421)
2010
10
Disruption of T cell suppression in chronic lymphocytic leukemia by CD200 blockade. (18838168)
2009
11
T-cell lymphoblastic lymphoma and T-cell acute lymphoblastic leukemia: a separate entity? (19778844)
2009
12
T cell leukemia/lymphoma 1 and galectin-1 regulate survival/cell death pathways in human naive and IgM+ memory B cells through altering balances in Bcl-2 family proteins. (19155496)
2009
13
Vaccination of B-CLL patients with autologous dendritic cells can change the frequency of leukemia antigen-specific CD8+ T cells as well as CD4+CD25+FoxP3+ regulatory T cells toward an antileukemia response. (18323802)
2008
14
In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia. (18322257)
2008
15
Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia. (18577685)
2008
16
The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia. (18299449)
2008
17
Adult T-cell leukemia/lymphoma with multiple integration of HTLV-1 provirus presenting as an isolated paranasal sinus tumor: a case report. (18023035)
2008
18
A genomic analysis of adult T-cell leukemia. (16909099)
2007
19
Antibody microarray analysis of inflammatory mediator release by human leukemia T-cells and human non small cell lung cancer cells. (17916797)
2007
20
Identification of an immunogenic CD8+ T-cell epitope derived from gamma-globin, a putative tumor-associated antigen for juvenile myelomonocytic leukemia. (16778141)
2006
21
Characterization of T-cell repertoire in hairy cell leukemia patients before and after recombinant immunotoxin BL22 therapy. (16311729)
2006
22
Identification of HLA class I-restricted tumor-associated antigens in adult T cell leukemia cells by mass spectrometric analysis. (17046569)
2006
23
Pediatric T-cell acute lymphoblastic leukemia with aberrations of both MLL loci. (16772125)
2006
24
CD4/CD8 double-positive, acute type of adult T-cell leukemia/lymphoma with extensive cutaneous involvement. (17040438)
2006
25
Serum level of soluble CD30 correlates with the aggressiveness of adult T-cell leukemia/lymphoma. (16271075)
2005
26
Imatinib mesylate suppresses cytokine synthesis by activated CD4 T cells of patients with chronic myelogenous leukemia. (16151467)
2005
27
The genetic background as a determinant of human T-cell leukemia virus type 1 proviral load. (12943677)
2003
28
Notch, a unifying target in T-cell acute lymphoblastic leukemia? (12524208)
2003
29
Human T-cell leukemia virus type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax. (11861831)
2002
30
5'-long terminal repeat-selective CpG methylation of latent human T-cell leukemia virus type 1 provirus in vitro and in vivo. (12186921)
2002
31
Mechanism of hypercalcemia in adult T-cell leukemia: overexpression of receptor activator of nuclear factor kappaB ligand on adult T-cell leukemia cells. (11781248)
2002
32
Human T cell leukemia virus type-I Tax activates human macrophage inflammatory protein-3 alpha/CCL20 gene transcription via the NF-kappa B pathway. (11809734)
2002
33
Cytokine expression of T cells in chronic myeloid leukemia. (11775253)
2000
34
Detection of methylthioadenosine phosphorylase (MTAP) and p16 gene deletion in T cell acute lymphoblastic leukemia by real-time quantitative PCR assay. (10803528)
2000
35
Molecular interactions involved in the transactivation of the human T-cell leukemia virus type 1 promoter mediated by Tax and CREB-2 (ATF-4). (10779337)
2000
36
Lymphoid organs as a major reservoir for human T-cell leukemia virus type 1 in experimentally infected squirrel monkeys (Saimiri sciureus): provirus expression, persistence, and humoral and cellular immune responses. (10775625)
2000
37
Phosphorylation of the human T-cell leukemia virus type 1 transactivator tax on adjacent serine residues is critical for tax activation. (9847380)
1999
38
Frequent deletion in the methylthioadenosine phosphorylase gene in T-cell acute lymphoblastic leukemia: strategies for enzyme-targeted therapy. (8874207)
1996
39
Constitutive overexpression of the L-selectin gene in fresh leukemic cells of adult T-cell leukemia that can be transactivated by human T-cell lymphotropic virus type 1 Tax. (7579405)
1995
40
Establishment and characterization of a novel cell line, TK-6, derived from T cell blast crisis of chronic myelogenous leukemia, with the secretion of parathyroid hormone-related protein. (7475285)
1995
41
Detection of neutralizing antibodies against human T-cell leukemia virus type 1 using a cell-free infection system and polymerase chain reaction. (7927951)
1994
42
Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals. (8230424)
1993
43
Regulation of eosinophil migration by adult T cell leukemia-derived factor. (8228251)
1993
44
Lineage promiscuity in leukemia studies of T-cell receptor and immunoglobulin genes. (8388969)
1993
45
Interleukin-2 increases production and secretion of parathyroid hormone-related peptide by human T cell leukemia virus type I-infected T cells: possible role in hypercalcemia associated with adult T cell leukemia. (8099324)
1993
46
Induction of interdigitating reticulum cell-like differentiation in human monocytic leukemia cells by conditioned medium from IL-2-stimulated helper T-cells. (1355319)
1992
47
Antigen-specific recognition of autologous leukemia cells and allogeneic class-I MHC antigens by IL-2-activated cytotoxic T cells from a patient with acute T-cell leukemia. (2546621)
1989
48
Analysis of T-cell-derived factors with the use of B-prolymphocytic leukemia cells. (3257174)
1988
49
T-lymphoblasts with erythropoietic helper function in acute T-cell leukemia. (2978965)
1986
50
Null-cell leukemia in course of T-cell lymphoma. (6970352)
1981

Genetic Variations for T-Cell Leukemia

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Expression for genes affiliated with T-Cell Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with T-Cell Leukemia

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Pathways for genes affiliated with T-Cell Leukemia

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29KEGG
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Pathways related to T-Cell Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9PBX3, TLX1, TLX3

Compounds for genes affiliated with T-Cell Leukemia

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44Novoseek
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Compounds related to T-Cell Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1[alcl]4410.8BCL3, MCL1
2cobalt chloride4410.5SLC2A1, MCL1

GO Terms for genes affiliated with T-Cell Leukemia

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16Gene Ontology
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Cellular components related to T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563412.2BCL3, TLX3, TLX1, FOXN2, MCL1, TAL1

Biological processes related to T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spleen developmentGO:04853610.8BCL3, TLX1
2regulation of respiratory gaseous exchange by neurological system processGO:00208710.5PBX3, TLX3

Molecular functions related to T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:00370011.6BCL3, TLX2, TLX3, TLX1, FOXN2, TAL1
2sequence-specific DNA bindingGO:04356511.6TLX3, TLX1, FOXN2, PBX3, PBX4, PBX2

Products for genes affiliated with T-Cell Leukemia

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Sources for T-Cell Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet