MCID: TCL004
MIFTS: 43

T-Cell Leukemia malady

Cancer diseases, Skin diseases, Blood diseases, Rare diseases, Immune diseases categories

Summaries for T-Cell Leukemia

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Wikipedia:63 T-cell leukemia describes several different types of lymphoid leukemia which affect T cells. more...

MalaCards based summary: T-Cell Leukemia, also known as leukemia, t-cell, is related to leukemia and lymphoblastic leukemia. An important gene associated with T-Cell Leukemia is TAL1 (T-cell acute lymphocytic leukemia 1). Affiliated tissues include t cells, skin and b cells, and related mouse phenotypes are nervous system and cellular.

Aliases & Classifications for T-Cell Leukemia

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 33MeSH
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T-Cell Leukemia, Aliases & Descriptions:

Name: T-Cell Leukemia 9 11
Leukemia, T-Cell 60
 
Leukemia T-Cell 43


Classifications:



External Ids:

Disease Ontology9 DOID:715
MeSH33 D015458

Related Diseases for T-Cell Leukemia

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Diseases in the T-Cell Leukemia family:

Adult T-Cell Leukemia Acute T Cell Leukemia
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic

Diseases related to T-Cell Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.4TLX3, TLX1, TCL1A, HTLVR, TAL1, CD7
2lymphoblastic leukemia30.9TLX1
3lymphoblastic lymphoma30.3CD7, TAL1
4burkitt lymphoma30.0TLX1, TCL1B, TCL1A, TAL1, CD7
5adult t-cell leukemia11.5
6human t-cell leukemia virus type 111.4
7human t-cell leukemia virus type 210.8
8spastic paraparesis10.8
9spasticity10.8
10tropical spastic paraparesis10.8
11acute t cell leukemia10.8
12hematopoietic stem cell transplantation10.7
13hypercalcemia10.7
14hepatitis10.5
15endotheliitis10.5
16hiv-110.5
17mycosis fungoides10.4
18scabies10.4
19human t-cell leukemia virus type 310.4
20arthritis10.4
21peripheral t-cell lymphoma10.4
22cutaneous t cell lymphoma10.4
23pneumonia10.4
24prolymphocytic leukemia10.4
25pediatric t-cell leukemia10.4
26hepatitis c virus10.3
27b-cell lymphomas10.3
28hepatitis b10.3
29hepatitis c10.3
30strongyloidiasis10.3
31follicular mucinosis10.3
32eosinophilia10.3
33herpes simplex10.3
34retinitis10.3
35large granular lymphocyte leukemia10.3
36rheumatoid arthritis10.3
37chronic lymphocytic leukemia10.3
38acute pancreatitis10.3
39norwegian scabies10.3
40arthropathy10.3
41dermatitis10.3
42meningitis10.3
43neuropathy10.3
44pancreatitis10.3
45uveitis10.3
46blastic plasmacytoid dendritic cell10.3
47htlv-1 associated myelopathy/tropical spastic paraparesis10.3
48htlv-1 associated myelopathy10.3
49ataxia-telangiectasia10.2
50lung cancer10.2

Graphical network of the top 20 diseases related to T-Cell Leukemia:



Diseases related to t-cell leukemia

Symptoms for T-Cell Leukemia

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Drugs & Therapeutics for T-Cell Leukemia

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Drug clinical trials:

Search ClinicalTrials for T-Cell Leukemia

Search NIH Clinical Center for T-Cell Leukemia

Genetic Tests for T-Cell Leukemia

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Anatomical Context for T-Cell Leukemia

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MalaCards organs/tissues related to T-Cell Leukemia:

31
T cells, Skin, B cells, Bone, Lung, Liver, Endothelial, Myeloid, Monocytes, Bone marrow, Lymph node, Colon, Breast, Testes, Spleen, Brain, Retina, Thymus, Thyroid, Testis, Pituitary, Neutrophil

Animal Models for T-Cell Leukemia or affiliated genes

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MGI Mouse Phenotypes related to T-Cell Leukemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.4TLX3, TLX1, TLX2, PMAIP1, VAC14, PBX2
2MP:00053848.3PMAIP1, VAC14, PBX2, TAX1BP1, TAL1, SLC2A1
3MP:00053878.3CD7, TLX3, TLX1, PMAIP1, PBX2, PDLIM2
4MP:00053978.2TLX1, PMAIP1, PBX2, PDLIM2, TAX1BP1, TAL1
5MP:00107687.6TLX3, TLX2, PMAIP1, EPC1, VAC14, PBX2

Publications for T-Cell Leukemia

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Articles related to T-Cell Leukemia:

(show top 50)    (show all 1684)
idTitleAuthorsYear
1
HTLV-1-infected CD4+ T-cells display alternative exon usages that culminate in adult T-cell leukemia. (25519886)
2014
2
Involvement of double-stranded RNA-dependent protein kinase and antisense viral RNA in the constitutive NFI_B activation in adult T-cell leukemia/lymphoma cells. (25567137)
2014
3
LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription. (23577667)
2013
4
Stevens-Johnson Syndrome associated with mogamulizumab treatment of adult T-cell leukemia / lymphoma. (23360455)
2013
5
CD4 and CD8 double-negative adult T-cell leukemia/lymphoma with monomorphic cells expressing CD99: a diagnostic challenge in a country non-endemic for human T-cell leukemia virus. (23464972)
2013
6
Human T cell leukemia virus type 2 tax-mediated NF-I_B activation involves a mechanism independent of Tax conjugation to ubiquitin and SUMO. (23135727)
2013
7
Mogamulizumab for the treatment of adult T-cell leukemia/lymphoma. (23110261)
2012
8
Increase in incidence of adult T-cell leukemia/lymphoma in non-endemic areas of Japan and the United States. (22738276)
2012
9
Anti-adult T-cell leukemia effects of Bidens pilosa. (21318218)
2011
10
C-terminal domain modulates the nucleic acid chaperone activity of human T-cell leukemia virus type 1 nucleocapsid protein via an electrostatic mechanism. (19887455)
2010
11
Clinical and laboratory features in adult T-cell leukemia/lymphoma in Khorasan, Iran. (20178409)
2010
12
Features of primary extranodal lymphoma in Kanagawa, a human T-cell leukemia virus type 1 nonendemic area in Japan. (18568429)
2009
13
PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients. (18830259)
2009
14
Cardiac involvement with human T-cell lymphotrophic virus type-1-associated adult T-cell leukemia/lymphoma: The NIH experience. (18297519)
2008
15
Human T-cell leukemia virus type 1 infection leads to arrest in the G1 phase of the cell cycle. (18596104)
2008
16
Rearranged NF-kappa B2 gene in an adult T-cell leukemia cell line. (18377428)
2008
17
Fludarabine induces apoptosis of human T-cell leukemia virus type 1-infected T cells via inhibition of the nuclear factor-kappaB signal pathway. (17344917)
2007
18
The role of WWP1-Gag interaction and Gag ubiquitination in assembly and release of human T-cell leukemia virus type 1. (17609263)
2007
19
Stem cell properties and the side population cells as a target for interferon-alpha in adult T-cell leukemia/lymphoma. (17977513)
2007
20
NOTCH1-induced T-cell leukemia in transgenic zebrafish. (17252014)
2007
21
Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. (17173050)
2007
22
Inactivation of p14ARF as a key event for the progression of adult T cell leukemia/lymphoma. (18246599)
2007
23
Blocking NF-kappaB as a potential strategy to treat adult T-cell leukemia/lymphoma. (16823495)
2006
24
Comparison of antigenic sites of the envelope glycoprotein of the Iranian isolate of human T-cell leukemia virus type 1 with different subtypes of the virus. (16883437)
2006
25
Induction of human T cell leukemia virus type I receptors on quiescent naive T lymphocytes by TGF-beta. (15778389)
2005
26
Transcriptional regulation of parathyroid hormone-related protein promoter P3 by ETS-1 in adult T-cell leukemia/lymphoma. (15889157)
2005
27
Identification of two new HLA-A*1101-restricted tax epitopes recognized by cytotoxic T lymphocytes in an adult T-cell leukemia patient after hematopoietic stem cell transplantation. (16014972)
2005
28
Narrow substrate specificity and sensitivity toward ligand-binding site mutations of human T-cell Leukemia virus type 1 protease. (15102858)
2004
29
Tax-independent constitutive IkappaB kinase activation in adult T-cell leukemia cells. (15153339)
2004
30
Deoxycoformycin-containing combination chemotherapy for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study (JCOG9109). (12627852)
2003
31
Human T-cell leukemia virus type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax. (11861831)
2002
32
Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12(I) protein. (11390610)
2001
33
The contribution of NF-kappa B activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 Tax-induced tumors. (11493471)
2001
34
Identification of a human T-cell leukemia virus type I tax peptide in contact with DNA. (10567395)
1999
35
Multiple osteolysis of peripheral extremities in a patient with adult T cell leukemia/lymphoma. (10526948)
1999
36
The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IkappaB kinases containing IKKalpha and IKKbeta. (9632633)
1998
37
Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb. (9584203)
1998
38
The human T-cell leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor groove. (9668114)
1998
39
Molecular analysis of the t(8;14)(q24;q11) chromosomal breakpoint junctions in the T-cell leukemia line MOLT-16. (9408752)
1997
40
Role of intracellular redox status in apoptosis induction of human T-cell leukemia virus type I-infected lymphocytes by 13-cis-retinoic acid. (9354458)
1997
41
Among all human T-cell leukemia virus type 1 proteins, tax, polymerase, and envelope proteins are predicted as preferential targets for the HLA-A2-restricted cytotoxic T-cell response. (8763995)
1996
42
Imidazole antifungals Miconazole and Econazole induce apoptosis in mouse lymphoma and human T cell leukemia cells: regulation by Bcl-2 and potential role of calcium. (17180102)
1996
43
Prevalence of human T-cell leukemia virus type 1 (HTLV-I) in family members of adult T-cell leukemia (ATL) patients in non-ATL-endemic Hokkaido of Japan. (7669948)
1995
44
Adhesion properties of adult T cell leukemia cells. (7787750)
1995
45
Mitochondrial induction of adult T cell leukemia derived factor (ADF/hTx) after oxidative stresses in retinal pigment epithelial cells. (8206709)
1994
46
Phorbol esters modulate the phosphorylation of human T-cell leukemia virus type I Tax. (8510230)
1993
47
A new regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1 and cloning of cDNAs encoding its binding proteins. (8350401)
1993
48
Reactive oxygen-reducing and protein-refolding activities of adult T cell leukemia-derived factor/human thioredoxin. (1510657)
1992
49
Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1. (3024966)
1986
50
t(11;19)(q23;p11) in a child with acute T-cell leukemia. (3855377)
1985

Variations for T-Cell Leukemia

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Expression for genes affiliated with T-Cell Leukemia

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Search GEO for disease gene expression data for T-Cell Leukemia.

Pathways for genes affiliated with T-Cell Leukemia

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Compounds for genes affiliated with T-Cell Leukemia

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GO Terms for genes affiliated with T-Cell Leukemia

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Cellular components related to T-Cell Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00056348.3TAL1, PDLIM2, FOXN2, PBX2, EPC1, PMAIP1

Biological processes related to T-Cell Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell fate commitmentGO:004516510.1TAL1, TLX1
2cellular response to glucose starvationGO:00421499.8SLC2A1, PMAIP1

Molecular functions related to T-Cell Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1kinase bindingGO:00199009.7SLC2A1, TAX1BP1
2sequence-specific DNA bindingGO:00435659.2FOXN2, PBX2, TLX2, TLX1, TLX3
3sequence-specific DNA binding transcription factor activityGO:00037008.8TLX3, TLX1, TLX2, PBX2, FOXN2, TAL1

Products for genes affiliated with T-Cell Leukemia

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Sources for T-Cell Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet