MCID: TCL004
MIFTS: 47

T-Cell Leukemia malady

Categories: Cancer diseases, Immune diseases, Blood diseases, Rare diseases, Skin diseases

Aliases & Classifications for T-Cell Leukemia

Aliases & Descriptions for T-Cell Leukemia:

Name: T-Cell Leukemia 12 14
Leukemia, T-Cell 42 69
Leukemia T-Cell 52

Classifications:



External Ids:

Disease Ontology 12 DOID:715
MeSH 42 D015458
UMLS 69 C0023492

Summaries for T-Cell Leukemia

MalaCards based summary : T-Cell Leukemia, also known as leukemia, t-cell, is related to adult t-cell leukemia and human t-cell leukemia virus type 1. An important gene associated with T-Cell Leukemia is TCL1A (T-Cell Leukemia/Lymphoma 1A), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Insulin resistance. The drugs Dexamethasone and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and bone.

Related Diseases for T-Cell Leukemia

Diseases in the T-Cell Leukemia family:

Adult T-Cell Leukemia Acute T Cell Leukemia
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic

Diseases related to T-Cell Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
id Related Disease Score Top Affiliating Genes
1 adult t-cell leukemia 12.6
2 human t-cell leukemia virus type 1 12.4
3 human t-cell leukemia virus type 2 12.4
4 acute t cell leukemia 12.2
5 human t-cell leukemia virus type 3 12.0
6 pediatric t-cell leukemia 12.0
7 t-cell prolymphocytic leukemia 11.4
8 htlv-1 associated myelopathy/tropical spastic paraparesis 11.4
9 tropical spastic paraparesis 11.3
10 lymphoid leukemia 11.2
11 leukemia 11.2
12 leukemia, t-cell, chronic 11.2
13 n syndrome 11.0
14 lymphoma 11.0
15 myelopathy, htlv-1-associated 10.9
16 retrovirus-associated myelopathy 10.9
17 hepatosplenic t-cell lymphoma 10.7
18 chronic interstitial cystitis 10.5
19 spastic paraparesis 10.4
20 spasticity 10.4
21 h. pylori infection 10.3
22 alcoholic hepatitis 10.3
23 follicular lymphoma 10.3
24 agammaglobulinemia 10.3
25 hematopoietic stem cell transplantation 10.3
26 cd40 ligand deficiency 10.2 LMO1 TAL1
27 hepatitis 10.1
28 bifid uvula 10.1 TAL1 TCL1A TLX1 TLX3
29 endotheliitis 10.1
30 hurst hallam hockey syndrome 10.1 CNTN2 CREB1 CRTC2 GLI2
31 hiv-1 10.1
32 mycosis fungoides 10.0
33 pneumonia 10.0
34 alcoholic liver cirrhosis 10.0 CD7 CNTN2 PMAIP1
35 peripheral t-cell lymphoma 10.0
36 scabies 10.0
37 arthritis 10.0
38 cutaneous t cell lymphoma 10.0
39 prolymphocytic leukemia 10.0
40 dermatitis 10.0
41 liver disease 9.9 TAL1 TCL1A TCL1B TCTA TLX1 TLX3
42 hepatitis c virus 9.9
43 b-cell lymphomas 9.9
44 hepatitis b 9.9
45 strongyloidiasis 9.9
46 hepatitis c 9.9
47 retinitis 9.9
48 arthropathy 9.9
49 herpes simplex 9.9
50 meningitis 9.9

Graphical network of the top 20 diseases related to T-Cell Leukemia:



Diseases related to T-Cell Leukemia

Symptoms & Phenotypes for T-Cell Leukemia

Drugs & Therapeutics for T-Cell Leukemia

Drugs for T-Cell Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 530)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
2
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
3
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
4
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 104987-11-3 445643 439492
5
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 20830-81-3 30323
6
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
7
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
8
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
9
Teniposide Approved Phase 4,Phase 2 29767-20-2 34698
10
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
11
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
12
Gemcitabine Approved Phase 4,Phase 2,Phase 1 95058-81-4 60750
13
Busulfan Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 55-98-1 2478
14
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1 174722-31-7 10201696
15
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 5754 657311
16
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1 3778-73-2 3690
17
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
18
alemtuzumab Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 216503-57-0
19
Thiotepa Approved Phase 4,Phase 3,Phase 2,Phase 1 52-24-4 5453
20
Lenograstim Approved Phase 4,Phase 3,Phase 2,Phase 1 135968-09-1
21
Thioguanine Approved Phase 4,Phase 3,Phase 2 154-42-7 2723601
22
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
23
Vindesine Approved Phase 4,Phase 3,Phase 2 59917-39-4, 53643-48-4 40839
24
Epirubicin Approved Phase 4,Phase 2 56420-45-2 41867
25
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
26
Asparaginase Approved Phase 4,Phase 3,Phase 2,Phase 1 9015-68-3
27
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 772 46507594
28
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
29
Acetaminophen Approved Phase 4,Phase 2 103-90-2 1983
30
Diphenhydramine Approved Phase 4,Phase 2 58-73-1, 147-24-0 3100
31
Daclizumab Approved, Investigational Phase 4,Phase 1,Phase 2 152923-56-3
32
Promethazine Approved Phase 4,Phase 2 60-87-7 4927
33
Cladribine Approved, Investigational Phase 4,Phase 2,Phase 1 4291-63-8 20279
34
Pancrelipase Approved Phase 4,Phase 1 53608-75-6
35
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-05-9 54575, 6560146 143
36
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59-30-3 6037
37
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1 31703
38 Prednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1
39 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1 1177-87-3
40 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
41 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
42 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
43 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
44 Cortisol succinate Phase 4,Phase 3,Phase 2,Phase 1
45 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
47 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
48 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
49 Dexamethasone 21-phosphate Phase 4,Phase 3,Phase 2,Phase 1
50 Hormones Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 1056)
id Name Status NCT ID Phase
1 Pilot Study of Combination Therapy With CHOP-Zenapax (CHOP-daclizumab) Completed NCT01418430 Phase 4
2 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4
3 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4
4 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4
5 CEOP/IVE/GDP Compared With CEOP as the First-line Therapy for Newly Diagnosed Adult Patients With PTCL Recruiting NCT02533700 Phase 4
6 ATG Could Improve the Outcome Of Hematopoietic Stem Cell Transplant in Patients With Highly Aggressive T Cell Tumors Recruiting NCT02290132 Phase 4
7 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
8 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4
9 Study of Alemtuzumab Versus Anti-thymocyte Globulin to Help Prevent Rejection in Kidney and Pancreas Transplantation Active, not recruiting NCT00331162 Phase 4
10 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3
11 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3
12 Early Hospital Discharge or Standard Inpatient Care in Cancer Patients Receiving Antibiotics for Febrile Neutropenia Unknown status NCT00445497 Phase 3
13 Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma Unknown status NCT00052936 Phase 3
14 Allogeneic Stem Cell Transplantation in CML With Partial T Cell Depletion Unknown status NCT00966810 Phase 2, Phase 3
15 Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia Unknown status NCT00764907 Phase 3
16 Two Combination Chemotherapy Regimens in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00707083 Phase 3
17 Decitabine Augments for Post Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndrome Unknown status NCT01809392 Phase 2, Phase 3
18 Treatment of Acute Lymphoblastic Leukemia in Children Unknown status NCT00400946 Phase 3
19 Standard Chemotherapy With or Without Nelarabine or Rituximab in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT01085617 Phase 3
20 Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma Unknown status NCT00003728 Phase 3
21 Combination Chemotherapy in Treating Children With Anaplastic Large Cell Lymphoma Unknown status NCT00006455 Phase 3
22 A Study for Aggressive Adult T-cell Leukemia-lymphoma (ATLL) Completed NCT00145002 Phase 3
23 Radiation Therapy in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma Who Have Undergone Stem Cell Transplantation Completed NCT00031668 Phase 3
24 Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count Completed NCT00003805 Phase 3
25 Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Completed NCT00661999 Phase 3
26 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
27 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3
28 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
29 Darbepoetin Alfa Compared With Epoetin Alfa in Treating Anemia in Patients Receiving Chemotherapy for Cancer Completed NCT00070382 Phase 3
30 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3
31 St. John's Wort in Relieving Fatigue in Patients Undergoing Chemotherapy or Hormone Therapy for Cancer Completed NCT00005805 Phase 3
32 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
33 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3
34 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3
35 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3
36 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3
37 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3
38 Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia or Advanced Lymphoblastic Non-Hodgkin's Lymphoma Completed NCT01230983 Phase 3
39 Chronic Graft-versus-host Disease (cGvHD) Prophylaxis With or Without ATG Prior to Stem Cell Transplantation (SCT) From HLA-identical Siblings in Patients With Acute Leukemia Completed NCT00678275 Phase 3
40 Bone Marrow Transplantation in Treating Patients With Acute Leukemia in First or Second Remission Completed NCT00002534 Phase 3
41 Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia Completed NCT00967057 Phase 3
42 T-Cell Depletion in Unrelated Donor Marrow Transplantation Completed NCT00000591 Phase 3
43 Bone Marrow Transplantation in Treating Patients With Leukemia, Myelodysplasia, or Lymphoblastic Lymphoma Completed NCT00003187 Phase 2, Phase 3
44 Study About Treatment of Newly Diagnosed Non Cutaneous Peripheral T Cell Lymphoma Completed NCT00970385 Phase 3
45 Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia Completed NCT00430118 Phase 3
46 Stem Cell Transplantation for Patients With Hematologic Malignancies Completed NCT00152139 Phase 3
47 Laboratory-Treated Donor Bone Marrow in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Hematologic Cancer Completed NCT00265837 Phase 3
48 Haploidentical Stem Cell Transplantation for Patients With Hematologic Malignancies Completed NCT00186823 Phase 3
49 Comparison of Two Combination Chemotherapy Regimens in Treating Adults With Previously Untreated Leukemia or Lymphoma Completed NCT00002766 Phase 3
50 Thymoglobuline in Non-myeloablative Allogeneic Stem-cell Transplantation Completed NCT00130754 Phase 3

Search NIH Clinical Center for T-Cell Leukemia

Cochrane evidence based reviews: leukemia, t-cell

Genetic Tests for T-Cell Leukemia

Anatomical Context for T-Cell Leukemia

MalaCards organs/tissues related to T-Cell Leukemia:

39
T Cells, Skin, Bone, B Cells, Lung, Liver, Endothelial

Publications for T-Cell Leukemia

Articles related to T-Cell Leukemia:

(show top 50) (show all 1846)
id Title Authors Year
1
Acute myelitis resembling human T-lymphotropic virus type 1-associated myelopathy presenting as high-signal-intensity long cord lesions on T2-weighted magnetic resonance images combined with lymphoma-type adult T-cell leukemia/lymphoma. ( 27817856 )
2017
2
Hematopoeitic stem cell transplantation for adult T cell leukemia-lymphoma: Who is the best candidate? ( 27786571 )
2017
3
Dismal outcome of allogeneic hematopoietic stem cell transplantation for relapsed adult T-cell leukemia/lymphoma, a Japanese nation-wide study. ( 28067877 )
2017
4
T-cell leukemia/lymphoma-1A predicts the clinical outcome for patients with stage II/III colorectal cancer. ( 28178623 )
2017
5
Evaluation of INOS, ICAM-1, and VCAM-1 gene expression: A study of adult T cell leukemia malignancy associated with HTLV-1. ( 28110427 )
2017
6
Suppression of protein tyrosine phosphatase PTPN22 gene induces apoptosis in T-cell leukemia cell line (Jurkat) through the AKT and ERK pathways. ( 27936393 )
2017
7
Epigenetic Silencing of the Human 18a88kDa Translocator Protein in a T Cell Leukemia Cell Line. ( 28004979 )
2017
8
Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells. ( 28075522 )
2017
9
Erratum to: Endemic impact of human T cell leukemia virus type 1 screening in bone allografts. ( 27770291 )
2016
10
Oncogenic mutations in the FBXW7 gene of adult T-cell leukemia patients. ( 27247421 )
2016
11
Development of engineered T cells expressing a chimeric CD16-CD3IP receptor to improve the clinical efficacy of mogamulizumab therapy against adult T cell leukemia. ( 27091408 )
2016
12
I^-Catenin is required for T-cell leukemia initiation and MYC transcription downstream of Notch1. ( 27125305 )
2016
13
Effector regulatory T cells reflect the equilibrium between antitumor immunity and autoimmunity in adult T cell leukemia. ( 27215229 )
2016
14
Impaired expression of DICER and some microRNAs in HBZ expressing cells from acute adult T-cell leukemia patients. ( 26849145 )
2016
15
Early leukemic transformation of adult T-cell leukemia/lymphoma presenting as meningeal lymphoma. ( 27862199 )
2016
16
Phase II study of alemtuzumab (CAMPATH-1Ar) in patients with HTLV-1-associated adult T-cell leukemia/lymphoma. ( 27486175 )
2016
17
Transition of adult T-cell leukemia/lymphoma clones during clinical progression. ( 27383637 )
2016
18
Acute interstitial nephritis in T-cell leukemia in a pediatric patient. ( 27594450 )
2016
19
Adult T-Cell Leukemia/Lymphoma: Rarely Encountered in the United States. ( 27521318 )
2016
20
Phosphatase PRL2 promotes oncogenic NOTCH1-Induced T-cell leukemia. ( 27872499 )
2016
21
Functional Comparison of HBZ and the Related APH-2 Protein Provides Insight into Human T-Cell Leukemia Virus Type 1 Pathogenesis. ( 26819304 )
2016
22
Lenalidomide in Adult T-Cell Leukemia/Lymphoma. ( 27863193 )
2016
23
Adult T-cell leukemia/lymphoma in donor cells responding to second allogeneic hematopoietic stem cell transplantation using unrelated cord blood: the Nagasaki Transplant Group experience. ( 27210445 )
2016
24
Clinical significance of CD70 expression on T cells in human T-lymphotropic virus type-1 carriers and adult T cell leukemia/ lymphoma patients. ( 26077361 )
2016
25
Induction of Cell Death in Growing Human T-Cells and Cell Survival in Resting Cells in Response to the Human T-Cell Leukemia Virus Type 1 Tax. ( 26829041 )
2016
26
Mutation of epigenetic regulators TET2 and MLL3 in patients with HTLV-I-induced acute adult T-cell leukemia. ( 26880370 )
2016
27
Torin2 Potentiates Anticancer Effects on Adult T-Cell Leukemia/Lymphoma by Inhibiting Mammalian Target of Rapamycin. ( 26722032 )
2016
28
LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding. ( 26598604 )
2016
29
All-trans retinoic acid and interferon-I+ increase CD38 expression on adult T-cell leukemia cells and sensitize them to T cells bearing anti-CD38 chimeric antigen receptors. ( 27176797 )
2016
30
Multicenter Phase II Study of Lenalidomide in Relapsed or Recurrent Adult T-Cell Leukemia/Lymphoma: ATLL-002. ( 27621400 )
2016
31
Relationship between triterpenoid anticancer drug resistance, autophagy, and caspase-1 in adult T-cell leukemia. ( 27190722 )
2016
32
Uchiyama T, Yodoi J, Sagawa K, Takatsuki K, Uchino H. Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood. 1977;50(3):481-492. ( 27979862 )
2016
33
Endemic impact of human T cell leukemia virus type 1 screening in bone allografts. ( 27677902 )
2016
34
Recurrence of Psoriasis Vulgaris Accompanied by Treatment with C-C Chemokine Receptor Type 4 (CCR4) Antibody (Mogamulizumab) Therapies in a Patient with Adult T cell Leukemia/ Lymphoma: Insight into Autoinflammatory Diseases. ( 27181545 )
2016
35
Adult T-Cell leukemia/lymphoma in the Caribbean cohort is a distinct clinical entity with dismal response to conventional chemotherapy. ( 27341021 )
2016
36
The Tax-Inducible Actin-Bundling Protein Fascin Is Crucial for Release and Cell-to-Cell Transmission of Human T-Cell Leukemia Virus Type 1 (HTLV-1). ( 27776189 )
2016
37
Rocaglamide breaks TRAIL-resistance in human multiple myeloma and acute T-cell leukemia inA vivo in a mouse xenogtraft model. ( 27998762 )
2016
38
Tax fingerprint in adult T-cell leukemia. ( 27056993 )
2016
39
Human T-cell leukemia virus type 1-positive lymphomatoid papulosis. ( 26771231 )
2016
40
Induction of apoptosis by HBI-8000 in adult T-cell leukemia/lymphoma is associated with activation of Bim and NLRP3. ( 27193821 )
2016
41
Permissive Sense and Antisense Transcription from the 5' and 3' Long Terminal Repeats of Human T-Cell Leukemia Virus Type 1. ( 26792732 )
2016
42
Alopecia areata, thyroiditis and vitiligo vulgaris in a Japanese patient with smoldering type adult T-cell leukemia/lymphoma. ( 27651025 )
2016
43
Effects of first-line chemotherapy on natural killer cells in adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma. ( 27289375 )
2016
44
Therapeutic potential and functional interaction of carfilzomib and vorinostat in T-cell leukemia/lymphoma. ( 27074555 )
2016
45
Human T-cell leukemia virus type 1 (HTLV-1) Tax1 oncoprotein but not HTLV-2 Tax2 induces the expression of OX40 ligand by interacting with p52/p100 and RelB. ( 26739459 )
2016
46
Human T-cell leukemia virus-associated malignancy. ( 27591679 )
2016
47
Adult T cell leukemia aggressivenness correlates with loss of both 5-hydroxymethylcytosine and TET2 expression. ( 27903986 )
2016
48
Ascites Retention during Mogamulizumab Treatment in a Patient with Adult T-cell Leukemia/lymphoma. ( 27374686 )
2016
49
Dysregulation of c-Myb Pathway by Aberrant Expression of Proto-oncogene MYB Provides the Basis for Malignancy in Adult T-cell Leukemia/lymphoma Cells. ( 27307595 )
2016
50
Cytological diagnosis of adult T-cell leukemia/lymphoma in sputum. ( 26972585 )
2016

Variations for T-Cell Leukemia

Expression for T-Cell Leukemia

Search GEO for disease gene expression data for T-Cell Leukemia.

Pathways for T-Cell Leukemia

Pathways related to T-Cell Leukemia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.89 CDK6 CREB1 CRTC2 TCL1A TCL1B
2
Show member pathways
11.47 CREB1 CRTC2 SLC2A1
3 11.34 CREB1 CRTC2 SLC2A1
4 10.38 TLX1 TLX2 TLX3

GO Terms for T-Cell Leukemia

Biological processes related to T-Cell Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.73 GLI2 TAL1 TCL1A TLX1 TLX2 TLX3
2 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.17 CREB1 CRTC2 GLI2 LMO1 TAL1 TLX1
3 generation of neurons GO:0048699 9.16 CDK6 TAL1
4 hematopoietic stem cell differentiation GO:0060218 8.96 CDK6 TAL1

Molecular functions related to T-Cell Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.1 CREB1 FOXN2 GLI2 TLX1 TLX2 TLX3

Sources for T-Cell Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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