MCID: TCL004
MIFTS: 49

T-Cell Leukemia malady

Summaries for T-Cell Leukemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 T-cell leukemia describes several different types of lymphoid leukemia which affect T cells. more...

MalaCards: T-Cell Leukemia, also known as leukemia, t-cell, is related to leukemia and lymphoblastic leukemia. An important gene associated with T-Cell Leukemia is TAL1 (T-cell acute lymphocytic leukemia 1), and among its related pathways is Transcriptional misregulation in cancer. The compounds [alcl] and cobalt chloride have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and myeloid.

Aliases & Classifications for T-Cell Leukemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH
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Aliases & Descriptions:

t-cell leukemia 8 10
leukemia, t-cell 60
leukemia t-cell 44


External Ids:

Disease Ontology8 DOID:715
MeSH34 D015458

Related Diseases for T-Cell Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Acute T Cell Leukemia family:

Adult T-Cell Leukemia t-cell leukemia
Leukemia, B-Cell, Chronic Leukemia, T-Cell, Chronic
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3

Diseases related to T-Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.5BCL3, TLX3, TLX1, HTLVR, CD7, MCL1
2lymphoblastic leukemia30.7TLX1
3hodgkin's lymphoma30.5BCL3, TCL1A, MCL1
4chronic lymphocytic leukemia30.5MCL1, TCL1A, BCL3
5adult t-cell leukemia11.5
6adult lymphoma11.3
7acute t cell leukemia10.9
8acute leukemia10.9
9tropical spastic paraparesis10.8
10hypercalcemia10.6
11cutaneous t cell lymphoma10.6
12adult syndrome10.5
13hepatitis10.5
14bone lymphoma10.5
15lymphoid leukemia10.4
16central nervous system leukemia10.4
17mycosis fungoides10.4
18monocytic leukemia10.4
19scabies10.4
20t cell deficiency10.4
21myeloid leukemia10.4
22pneumonia10.4
23prolymphocytic leukemia10.4
24human t-cell leukemia virus type 110.4
25human t-cell leukemia virus type 210.4
26human t-cell leukemia virus type 310.4
27strongyloidiasis10.3
28hepatitis c10.3
29gastric lymphoma10.3
30arthritis10.3
31childhood leukemia10.3
32dermatitis10.3
33eosinophilia10.3
34herpes simplex10.3
35retinitis10.3
36pediatric t-cell leukemia10.3
37graft versus host disease10.3
38norwegian scabies10.3
39acute pancreatitis10.3
40natural killer cell leukemia10.3
41follicular mucinosis10.3
42orbit lymphoma10.3
43anaplastic large cell lymphoma10.3
44t-cell large granular lymphocyte leukemia10.3
45hepatitis a10.3
46arthropathy10.3
47meningitis10.3
48neuropathy10.3
49pancreatitis10.3
50uveitis10.3

Graphical network of the top 20 diseases related to T-Cell Leukemia:



Diseases related to t-cell leukemia

Clinical Features for T-Cell Leukemia

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Drugs & Therapeutics for T-Cell Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for T-Cell Leukemia

Drug clinical trials:

Search ClinicalTrials for T-Cell Leukemia

Search NIH Clinical Center for T-Cell Leukemia

Search CenterWatch for T-Cell Leukemia

Genetic Tests for T-Cell Leukemia

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Anatomical Context for T-Cell Leukemia

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32MalaCards
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MalaCards organs/tissues related to T-Cell Leukemia:

32
T cells, B cells, Myeloid, Bone, Bone marrow, Skin, Lung, Monocytes, Liver, Endothelial, Lymph node, Breast, Colon, Nk cells, Brain, Testes, Pituitary, Spleen, Thymus, Retina, Thyroid, Spinal cord, Heart, Testis, Eye, Prostate

Animal Models for T-Cell Leukemia or affiliated genes

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Publications for T-Cell Leukemia

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50PubMed
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Articles related to T-Cell Leukemia:

(show top 50)    (show all 2523)
idTitleAuthorsYear
1
Induction of molecular remission by using anti-CC-chemokine receptor 4 (anti-CCR4) antibodies for adult T cell leukemia: a risk of opportunistic infection after treatment with anti-CCR4 antibodies. (23612772)
2014
2
LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription. (23577667)
2013
3
The cellular autophagy pathway modulates human T-cell leukemia virus type 1 replication. (23175371)
2013
4
Interleukin-2 priming chemotherapy: a strategy to improve the remission of refractory/relapsed T cell acute lymphoblastic leukemia. (24074835)
2013
5
Wnt signaling in leukemias and myeloma: T-cell factors are in control. (24156335)
2013
6
Successful treatment by donor lymphocyte infusion of adult T-cell leukemia/lymphoma relapse following allogeneic hematopoietic stem cell transplantation. (22481502)
2012
7
Precursor T-cell acute lymphoblastic leukemia presenting with bone marrow necrosis: a case report. (23057758)
2012
8
Pediatric T-cell prolymphocytic leukemia with an isolated 12(p13) deletion and aberrant CD117 expression. (23211022)
2012
9
Different prognostic factors for survival in acute and lymphomatous adult T-cell leukemia/lymphoma. (20828817)
2011
10
Clonal evolution of adult T-cell leukemia/lymphoma takes place in the lymph nodes. (21447829)
2011
11
Integrase inhibitors effective against human T-cell leukemia virus type 1. (21343468)
2011
12
Leukemia's viral link: What role does a viral gene play in HTLV-1 infection's progression to T cell leukemia? (21834352)
2011
13
TLX1 and NOTCH coregulate transcription in T cell acute lymphoblastic leukemia cells. (20618946)
2010
14
The Notch/Hes1 pathway sustains NF-I_B activation through CYLD repression in T cell leukemia. (20832754)
2010
15
Development of a Wilms' tumor antigen-specific T-cell receptor for clinical trials: engineered patient's T cells can eliminate autologous leukemia blasts in NOD/SCID mice. (19679884)
2010
16
Depletion of dendritic cells enhances susceptibility to cell-free infection of human T cell leukemia virus type 1 in CD11c-diphtheria toxin receptor transgenic mice. (20382884)
2010
17
Maintenance and preemptive therapy with ganciclovir for cytomegalovirus colitis with extremely high antigenemia in adult T-cell leukemia. (19152101)
2009
18
Elevation of serum KL-6 glycoprotein or surfactant protein-D in adult T-cell leukemia with distinct pulmonary complications. (19478465)
2009
19
K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors. (18663146)
2008
20
Recent advances in adult T-cell leukemia therapy: focus on a new anti-transferrin receptor monoclonal antibody. (17898788)
2008
21
EAPB0203, a member of the imidazoquinoxaline family, inhibits growth and induces caspase-dependent apoptosis in T-cell lymphomas and HTLV-I-associated adult T-cell leukemia/lymphoma. (18218850)
2008
22
Stem cell properties and the side population cells as a target for interferon-alpha in adult T-cell leukemia/lymphoma. (17977513)
2007
23
Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. (17173050)
2007
24
Effects of HLA allele and killer immunoglobulin-like receptor ligand matching on clinical outcome in leukemia patients undergoing transplantation with T-cell-replete marrow from an unrelated donor. (17317585)
2007
25
Ascorbic acid induces apoptosis in adult T-cell leukemia. (17352246)
2007
26
Survey of chemokine receptor expression reveals frequent co-expression of skin-homing CCR4 and CCR10 in adult T-cell leukemia/lymphoma. (17071491)
2006
27
DNA fusion vaccines induce epitope-specific cytotoxic CD8(+) T cells against human leukemia-associated minor histocompatibility antigens. (16707472)
2006
28
Reduction of human T-cell leukemia virus type 1 (HTLV-1) proviral loads in rats orally infected with HTLV-1 by reimmunization with HTLV-1-infected cells. (16840318)
2006
29
Reduced expression of human mismatch repair genes in adult T-cell leukemia. (15682421)
2005
30
Late assembly motifs of human T-cell leukemia virus type 1 and their relative roles in particle release. (15163754)
2004
31
Reversible paraneoplastic neuropathy associated with T-cell large granular lymphocyte leukemia. (15304606)
2004
32
Genomic instability driven by the human T-cell leukemia virus type I (HTLV-I) oncoprotein, Tax. (12370813)
2002
33
Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane. (11960909)
2002
34
Chemotherapy targeting methylthioadenosine phosphorylase (MTAP) deficiency in adult T cell leukemia (ATL). (12200696)
2002
35
Susceptibility of human T cell leukemia virus type 1 to reverse-transcriptase inhibitors: evidence for resistance to lamivudine. (11471110)
2001
36
Cell-free entry of human T-cell leukemia virus type 1 to mouse cells. (11346463)
2001
37
Lactacystin activates FLICE (caspase 8) protease and induces apoptosis in Fas-resistant adult T-cell leukemia cell lines. (10863977)
2000
38
Improvement of quality of life after splenectomy in an HTLV-I carrier with T-cell prolymphocytic leukemia. (10609799)
1999
39
T-cell dysfunction in hairy cell leukemia: an updated review. (9669674)
1998
40
Increased expression of human thioredoxin/adult T cell leukemia-derived factor in SjAPgren's syndrome. (8639174)
1996
41
High prevalence of T cell receptor D delta 2(D delta)J delta rearrangement in CD7-positive early T cell acute lymphoblastic leukemia. (8618442)
1996
42
c-sis/PDGF-B promoter transactivation by the Yax protein of human T-cell leukemia virus type 1. (8662878)
1996
43
High levels of AP-2-binding activity in cell lines infected with human T-cell leukemia virus type I: possible enhancement of AP-2 binding by human T-cell leukemia virus type I tax. (8631013)
1996
44
Effects of translation initiation factor eIF-5A on the functioning of human T-cell leukemia virus type I Rex and human immunodeficiency virus Rev inhibited trans dominantly by a Rex mutant deficient in RNA binding. (7707541)
1995
45
In vitro infection of human macrophages with human T-cell leukemia virus type 1. (8453107)
1993
46
Expression and characterization of the trans-activating protein Tax of human T-cell leukemia virus type I in Saccharomyces cerevisiae. (1433517)
1992
47
T-cell receptor gamma/delta expressing acute leukemia emerging from sideroblastic anemia: morphological, immunological, and cytogenetic features. (1373459)
1992
48
The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. (2303035)
1990
49
SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. (2827008)
1988
50
Human serum thymic factor in detecting acute T cell leukemia. (311636)
1978

Genetic Variations for T-Cell Leukemia

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Expression for genes affiliated with T-Cell Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with T-Cell Leukemia

Search GEO for disease gene expression data for T-Cell Leukemia.

Pathways for genes affiliated with T-Cell Leukemia

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29KEGG
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Pathways related to T-Cell Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9PBX3, TLX1, TLX3

Compounds for genes affiliated with T-Cell Leukemia

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44Novoseek
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Compounds related to T-Cell Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1[alcl]4410.8BCL3, MCL1
2cobalt chloride4410.5SLC2A1, MCL1

GO Terms for genes affiliated with T-Cell Leukemia

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16Gene Ontology
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Cellular components related to T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563412.2BCL3, TLX3, TLX1, FOXN2, MCL1, TAL1

Biological processes related to T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spleen developmentGO:04853610.8BCL3, TLX1
2regulation of respiratory gaseous exchange by neurological system processGO:00208710.5PBX3, TLX3

Molecular functions related to T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:00370011.6BCL3, TLX2, TLX3, TLX1, FOXN2, TAL1
2sequence-specific DNA bindingGO:04356511.6TLX3, TLX1, FOXN2, PBX3, PBX4, PBX2

Products for genes affiliated with T-Cell Leukemia

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Sources for T-Cell Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet