MCID: TCL004
MIFTS: 46

T-Cell Leukemia

Categories: Cancer diseases, Immune diseases, Blood diseases, Rare diseases, Skin diseases

Aliases & Classifications for T-Cell Leukemia

MalaCards integrated aliases for T-Cell Leukemia:

Name: T-Cell Leukemia 12 14
Leukemia, T-Cell 42 69
Leukemia T-Cell 52

Classifications:



External Ids:

Disease Ontology 12 DOID:715
MeSH 42 D015458
UMLS 69 C0023492

Summaries for T-Cell Leukemia

MalaCards based summary : T-Cell Leukemia, also known as leukemia, t-cell, is related to alcoholic hepatitis and adult t-cell leukemia. An important gene associated with T-Cell Leukemia is TCL1A (T-Cell Leukemia/Lymphoma 1A), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Insulin resistance. The drugs Cyclophosphamide and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone.

Related Diseases for T-Cell Leukemia

Diseases in the T-Cell Leukemia family:

Adult T-Cell Leukemia Acute T Cell Leukemia
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic

Diseases related to T-Cell Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
id Related Disease Score Top Affiliating Genes
1 alcoholic hepatitis 30.7 CD7 CNTN2 PMAIP1
2 adult t-cell leukemia 12.6
3 human t-cell leukemia virus type 1 12.4
4 human t-cell leukemia virus type 2 12.4
5 acute t cell leukemia 12.2
6 human t-cell leukemia virus type 3 12.0
7 pediatric t-cell leukemia 12.0
8 htlv-1 associated myelopathy/tropical spastic paraparesis 11.4
9 t-cell prolymphocytic leukemia 11.3
10 tropical spastic paraparesis 11.3
11 leukemia 11.3
12 lymphoid leukemia 11.2
13 leukemia, t-cell, chronic 11.2
14 n syndrome 11.0
15 lymphoma 11.0
16 myelopathy, htlv-1-associated 10.9
17 retrovirus-associated myelopathy 10.9
18 hepatosplenic t-cell lymphoma 10.7
19 hunter macpherson syndrome 10.5 CNTN2 CREB1
20 chronic interstitial cystitis 10.5
21 spastic paraparesis 10.4
22 spasticity 10.4
23 h. pylori infection 10.3
24 follicular lymphoma 10.3
25 agammaglobulinemia 10.3
26 idiopathic syringomyelia 10.3 TAL1 TCL1A TLX1 TLX3
27 hematopoietic stem cell transplantation 10.3
28 hepatitis 10.1
29 endotheliitis 10.1
30 suppression amblyopia 10.1 LMO1 TAL1 TLX1 TLX3
31 coronin-1a deficiency 10.1 LMO1 TAL1
32 hiv-1 10.1
33 mycosis fungoides 10.0
34 pneumonia 10.0
35 peripheral t-cell lymphoma 10.0
36 scabies 10.0
37 liver cirrhosis 10.0 TAL1 TCL1A TCL1B TCTA TLX1 TLX3
38 hunter carpenter macdonald syndrome 10.0 CNTN2 CREB1 CRTC2 GLI2 SLC2A1
39 arthritis 10.0
40 cutaneous t cell lymphoma 10.0
41 prolymphocytic leukemia 10.0
42 uveitis 10.0
43 dermatitis 10.0
44 hepatitis c virus 9.9
45 b-cell lymphomas 9.9
46 hepatitis b 9.9
47 strongyloidiasis 9.9
48 hepatitis c 9.9
49 retinitis 9.9
50 arthropathy 9.9

Graphical network of the top 20 diseases related to T-Cell Leukemia:



Diseases related to T-Cell Leukemia

Symptoms & Phenotypes for T-Cell Leukemia

Drugs & Therapeutics for T-Cell Leukemia

Drugs for T-Cell Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 450)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
2
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
3
Teniposide Approved Phase 4,Phase 2 29767-20-2 34698
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
5
Epirubicin Approved Phase 4,Phase 2 56420-45-2 41867
6
Gemcitabine Approved Phase 4,Phase 2,Phase 1 95058-81-4 60750
7
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1 3778-73-2 3690
8
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
9
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
10
Busulfan Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 55-98-1 2478
11
Daclizumab Approved, Investigational Phase 4,Phase 1,Phase 2 152923-56-3
12
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
13 Antilymphocyte Serum Phase 4,Phase 3,Phase 2,Phase 1
14 Etoposide phosphate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
15 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
16 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
17 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
18 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
19 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
20 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
21 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
22 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1
23 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
24 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
25 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
26 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1
27 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1 1177-87-3
28 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
29 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
30 Hormones Phase 4,Phase 3,Phase 2,Phase 1
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
32 Isophosphamide mustard Phase 4,Phase 3,Phase 2,Phase 1
33 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
34
Cefepime Approved Phase 3 88040-23-7 5479537
35
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
36
Ofloxacin Approved Phase 3 82419-36-1 4583
37
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
38
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613 2171
39
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1 2764
40
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
41
Lenograstim Approved Phase 3,Phase 2,Phase 1 135968-09-1
42
rituximab Approved Phase 3,Phase 2,Phase 1 174722-31-7 10201696
43
Fludarabine Approved Phase 2, Phase 3, Phase 1 21679-14-1, 75607-67-9 30751
44
Iron Approved Phase 2, Phase 3, Phase 1 7439-89-6 23925
45
Asparaginase Approved Phase 3,Phase 2,Phase 1 9015-68-3
46
Cytarabine Approved, Investigational Phase 3,Phase 2,Phase 1 147-94-4 6253
47
Daunorubicin Approved Phase 3,Phase 2,Phase 1 20830-81-3 30323
48
Levoleucovorin Approved Phase 3,Phase 2,Phase 1 68538-85-2
49
Methotrexate Approved Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
50
Thioguanine Approved Phase 3,Phase 2 154-42-7 2723601

Interventional clinical trials:

(show top 50) (show all 789)

id Name Status NCT ID Phase Drugs
1 ATG Could Improve the Outcome Of Hematopoietic Stem Cell Transplant in Patients With Highly Aggressive T Cell Tumors Unknown status NCT02290132 Phase 4 Rabbit Anti-human Thymocyte Globulin (ATG)
2 Pilot Study of Combination Therapy With CHOP-Zenapax (CHOP-daclizumab) Completed NCT01418430 Phase 4 CHOP-daclizumab
3 CEOP/IVE/GDP Compared With CEOP as the First-line Therapy for Newly Diagnosed Adult Patients With PTCL Recruiting NCT02533700 Phase 4 CEOP/IVE/GDP chemotherapy regimen;CEOP chemotherapy regimen for 6 cycles
4 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
5 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
6 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Active, not recruiting NCT03226119 Phase 4
7 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
8 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
9 Early Hospital Discharge or Standard Inpatient Care in Cancer Patients Receiving Antibiotics for Febrile Neutropenia Unknown status NCT00445497 Phase 3 amoxicillin-clavulanate potassium;ciprofloxacin
10 Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma Unknown status NCT00052936 Phase 3 CHOP regimen;cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
11 Allogeneic Stem Cell Transplantation in CML With Partial T Cell Depletion Unknown status NCT00966810 Phase 2, Phase 3
12 Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia Unknown status NCT00764907 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine
13 Two Combination Chemotherapy Regimens in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00707083 Phase 3 dexamethasone;mercaptopurine;methotrexate;vincristine sulfate
14 Decitabine Augments for Post Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndrome Unknown status NCT01809392 Phase 2, Phase 3 decitabine
15 A Study for Aggressive Adult T-cell Leukemia-lymphoma (ATLL) Completed NCT00145002 Phase 3 VCAP-AMP-VECP with G-CSF and intrathecal prophylaxis;biweekly-CHOP with G-CSF and intrathecal prophylaxis
16 Radiation Therapy in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma Who Have Undergone Stem Cell Transplantation Completed NCT00031668 Phase 3
17 Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count Completed NCT00003805 Phase 3 piperacillin sodium;piperacillin-tazobactam;tazobactam sodium;vancomycin
18 Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
19 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
20 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3 American ginseng
21 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
22 Darbepoetin Alfa Compared With Epoetin Alfa in Treating Anemia in Patients Receiving Chemotherapy for Cancer Completed NCT00070382 Phase 3 darbepoetin alfa;epoetin alfa
23 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3 Fragmin
24 St. John's Wort in Relieving Fatigue in Patients Undergoing Chemotherapy or Hormone Therapy for Cancer Completed NCT00005805 Phase 3
25 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
26 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
27 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
28 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
29 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
30 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3 ondansetron
31 Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia or Advanced Lymphoblastic Non-Hodgkin's Lymphoma Completed NCT01230983 Phase 3 asparaginase;cytarabine;dexrazoxane hydrochloride;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;prednisone;therapeutic hydrocortisone;vincristine sulfate
32 Chronic Graft-versus-host Disease (cGvHD) Prophylaxis With or Without ATG Prior to Stem Cell Transplantation (SCT) From HLA-identical Siblings in Patients With Acute Leukemia Completed NCT00678275 Phase 3 ATG FRESENIUS (Anti-Lymphocyte-Globulin);ATG FRESENIUS (Anti-Lymphocyte-Globulin)
33 Bone Marrow Transplantation in Treating Patients With Acute Leukemia in First or Second Remission Completed NCT00002534 Phase 3 cyclophosphamide;cytarabine;methylprednisolone;thiotepa
34 Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia Completed NCT00967057 Phase 3 asparaginase;dexamethasone;idarubicin;methotrexate;mitoxantrone hydrochloride;pegaspargase;vincristine sulfate
35 T-Cell Depletion in Unrelated Donor Marrow Transplantation Completed NCT00000591 Phase 3
36 Bone Marrow Transplantation in Treating Patients With Leukemia, Myelodysplasia, or Lymphoblastic Lymphoma Completed NCT00003187 Phase 2, Phase 3 cyclophosphamide;cyclosporine;cytarabine;methotrexate;methylprednisolone
37 Study About Treatment of Newly Diagnosed Non Cutaneous Peripheral T Cell Lymphoma Completed NCT00970385 Phase 3 CHOP21;VIP/ABVD
38 Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia Completed NCT00430118 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine
39 Stem Cell Transplantation for Patients With Hematologic Malignancies Completed NCT00152139 Phase 3 Chemotherapy and antibodies
40 Laboratory-Treated Donor Bone Marrow in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Hematologic Cancer Completed NCT00265837 Phase 3
41 TK008: Efficacy Study on the Strategy of HSV-Tk Engineering Donor Lymphocytes to Treat Patients With High Risk Acute Leukemia Recruiting NCT00914628 Phase 3
42 Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma Recruiting NCT02112916 Phase 3 Bortezomib;Cyclophosphamide;Cytarabine;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin Hydrochloride;Etoposide;Hydrocortisone Sodium Succinate;Ifosfamide;Leucovorin Calcium;Mercaptopurine;Methotrexate;Pegaspargase;Thioguanine;Vincristine Sulfate
43 Peripheral Blood Stem Cell Transplantation for Hematologic Malignancies With Alpha Beta TCell and B Cell Depletion Using the CliniMACS Device Recruiting NCT02600208 Phase 2, Phase 3
44 Clofarabine or High-Dose Cytarabine and Pegaspargase in Children With ALL Recruiting NCT01228331 Phase 2, Phase 3 Amsacrine;Clofarabine;Cyclophosphamide;Cytarabine;Daunorubicin hydrochloride;Dexamethasone;Doxorubicin hydrochloride;Etoposide phosphate;Mercaptopurine;Methotrexate;Methylprednisolone;Pegaspargase;Thioguanine;Vincristine sulfate
45 CD45RA Depleted T-cell Infusion for Prevention of Infections After TCRab/CD19-depleted Allo-HSCT Recruiting NCT02942173 Phase 2, Phase 3
46 A French Protocol for the Treatment of Acute Lymphoblastic Leukemia (ALL) in Children and Adolescents Recruiting NCT02716233 Phase 3 pegaspargase 1250 IU/m2 x 2;pegaspargase 2500 IU/m2 x 1
47 Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma Recruiting NCT03117751 Phase 2, Phase 3 Prednisone;Vincristine;Daunorubicin;Pegaspargase;Erwinase®;Rituximab;Cyclophosphamide;Cytarabine;Mercaptopurine;Dasatinib;Methotrexate;Blinatumomab;Ruxolitinib;Bortezomib;Dexamethasone;Doxorubicin;Etoposide;Clofarabine;Vorinostat;Idarubicin
48 Phase 3 Trial of Blinatumomab vs Standard Chemotherapy in Pediatric Subjects With HR First Relapse B-precursor ALL Recruiting NCT02393859 Phase 3 Blinatumomab;Conventional Consolidation Chemotherapy
49 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma Active, not recruiting NCT00408005 Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin Hydrochloride;Leucovorin Calcium;Mercaptopurine;Methotrexate;Nelarabine;Pegaspargase;Prednisone;Thioguanine;Vincristine Sulfate
50 Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer Active, not recruiting NCT00003816 Phase 2, Phase 3 busulfan;carboplatin;cyclophosphamide;etoposide;fludarabine phosphate;melphalan;thiotepa

Search NIH Clinical Center for T-Cell Leukemia

Cochrane evidence based reviews: leukemia, t-cell

Genetic Tests for T-Cell Leukemia

Anatomical Context for T-Cell Leukemia

MalaCards organs/tissues related to T-Cell Leukemia:

39
T Cells, B Cells, Bone, Myeloid, Bone Marrow, Liver, Nk Cells

Publications for T-Cell Leukemia

Articles related to T-Cell Leukemia:

(show top 50) (show all 1881)
id Title Authors Year
1
Positive and Negative Regulation of Type I Interferons by the Human T Cell Leukemia Virus Antisense Protein HBZ. ( 28768861 )
2017
2
Proviral Features of Human T Cell Leukemia Virus Type 1 in Carriers with Indeterminate Western Blot Analysis Results. ( 28701419 )
2017
3
Detection of human T-cell lymphotropic virus type I-specific cytotoxic T-cells may predict treatment responses in adult T-cell leukemia/lymphoma patients. ( 28656327 )
2017
4
RNA stability regulates human T cell leukemia virus type 1 gene expression in chronically-infected CD4 T cells. ( 28478312 )
2017
5
The T-cell leukemia related rpl10-R98S mutant traps the 60S export adapter Nmd3 in the ribosomal P site in yeast. ( 28715419 )
2017
6
Galectin-9 as a Predictive Marker for the Onset of Immune-Related Adverse Effects Associated with Anti-CCR4 MoAb Therapy in Patients with Adult T Cell Leukemia. ( 28321034 )
2017
7
Welder's pulmonary hemosiderosis associated with systemic iron overload following exacerbation of acute adult T-cell leukemia/lymphoma. ( 28883221 )
2017
8
A Unique T-Cell Receptor Amino Acid Sequence Selected by Human T-Cell Lymphotropic Virus Type 1 Tax301-309-Specific Cytotoxic T Cells in HLA-A24:02-Positive Asymptomatic Carriers and Adult T-Cell Leukemia/Lymphoma Patients. ( 28724766 )
2017
9
Generalized rash and lymphocytosis as clinical onset adult T-cell leukemia/lymphoma. ( 28645687 )
2017
10
Hypersensitivity reaction to I^-lactam antibiotics in patients with adult T-cell leukemia/lymphoma treated with mogamulizumaba8c. ( 28793956 )
2017
11
The T-cell leukemia associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling. ( 28744013 )
2017
12
Epigenetic Silencing of the Human 18a88kDa Translocator Protein in a T Cell Leukemia Cell Line. ( 28004979 )
2017
13
Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. ( 28811663 )
2017
14
T-cell leukemia/lymphoma-1A predicts the clinical outcome for patients with stage II/III colorectal cancer. ( 28178623 )
2017
15
Flow cytometric-based protocols for assessing anti-MT-2 IgG1 reactivity: High-dimensional data handling to define predictors for clinical follow-up of Human T-cell Leukemia virus type-1 infection. ( 28212879 )
2017
16
Therapy-related Acute Myeloid Leukemia after the Long-term Administration of Low-dose Etoposide for Chronic-type Adult T-cell Leukemia-lymphoma: A Case Report and Literature Review. ( 28717086 )
2017
17
Dismal outcome of allogeneic hematopoietic stem cell transplantation for relapsed adult T-cell leukemia/lymphoma, a Japanese nation-wide study. ( 28067877 )
2017
18
Mogamulizumab for relapsed adult T-cell leukemia-lymphoma: Updated follow-up analysis of phase I and II studies. ( 28776876 )
2017
19
Epidemiological and clinical features of adult T-cell leukemia-lymphoma in Japan, 2010-2011: A nationwide survey. ( 28905463 )
2017
20
Genetic alterations in adult T-cell leukemia/lymphoma. ( 28627735 )
2017
21
Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells. ( 28075522 )
2017
22
Failure to prevent human T-cell leukemia virus type 1 mother-to-child transmission in Japan. ( 28211219 )
2017
23
Human T-cell leukemia virus type I Tax genotype analysis in Okinawa, the southernmost and remotest islands of Japan: Different distributions compared with mainland Japan and the potential value for the prognosis of aggressive adult T-cell leukemia/lymphoma. ( 28866351 )
2017
24
Suppression of protein tyrosine phosphatase PTPN22 gene induces apoptosis in T-cell leukemia cell line (Jurkat) through the AKT and ERK pathways. ( 27936393 )
2017
25
Early Onset of HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) and Adult T-cell Leukemia/Lymphoma (ATL): Systematic Search and Review. ( 28582585 )
2017
26
Mogamulizumab for the treatment of relapsed or refractory adult T-cell leukemia-lymphoma. ( 28756726 )
2017
27
Cyclin-dependent kinase 9 is a novel specific molecular target in adult T-cell leukemia/lymphoma. ( 28646117 )
2017
28
Hematopoeitic stem cell transplantation for adult T cell leukemia-lymphoma: Who is the best candidate? ( 27786571 )
2017
29
Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell Leukemia/Lymphoma by Suppressing the ERK1/2 Pathway. ( 28785594 )
2017
30
IL-10-mediated signals act as a switch for lymphoproliferation in Human T-cell leukemia virus type-1 infection by activating the STAT3 and IRF4 pathways. ( 28910419 )
2017
31
Adult T-cell leukemia cell-induced uveitis: rapid increase in adult T-cell leukemia cells disrupts the blood-ocular barrier. ( 28677112 )
2017
32
Evaluation of INOS, ICAM-1, and VCAM-1 gene expression: A study of adult T cell leukemia malignancy associated with HTLV-1. ( 28110427 )
2017
33
Anti-laminin-332-type mucous membrane pemphigoid in a patient with adult T-cell leukemia/lymphoma and graft-versus-host disease. ( 28771781 )
2017
34
Adult T cell leukemia aggressivenness correlates with loss of both 5-hydroxymethylcytosine and TET2 expression. ( 28881727 )
2017
35
Perturbation of Human T-Cell Leukemia Virus Type 1 Particle Morphology by Differential Gag Co-Packaging. ( 28753950 )
2017
36
Choices and Challenges in the Treatment of Adult T-Cell Leukemia/Lymphoma. ( 28796965 )
2017
37
Acute myelitis resembling human T-lymphotropic virus type 1-associated myelopathy presenting as high-signal-intensity long cord lesions on T2-weighted magnetic resonance images combined with lymphoma-type adult T-cell leukemia/lymphoma. ( 27817856 )
2017
38
Polymorphic Nature of Human T-Cell Leukemia Virus Type 1 Particle Cores as Revealed through Characterization of a Chronically Infected Cell Line. ( 28615198 )
2017
39
Effects of expressing human T-cell leukemia virus type 1 (HTLV-I) oncoprotein Tax on DOK1, DOK2 and DOK3 gene expression in mice. ( 28302940 )
2017
40
Human T Cell Leukemia Virus Type 1 and Eye Diseases. ( 28263674 )
2017
41
Detection of Tax-specific CTLs in lymph nodes of adult T-cell leukemia/lymphoma patients and its association with Foxp3 positivity of regulatory T-cell function. ( 28599462 )
2017
42
Adult T-Cell Leukemia/Lymphoma. ( 28796966 )
2017
43
Expression and significance of Pim-3 kinase in adult T-cell leukemia. ( 28833639 )
2017
44
Development of a complete human IgG monoclonal antibody to transferrin receptor 1 targeted for adult T-cell leukemia/lymphoma. ( 28189691 )
2017
45
Efficiency of AUY922 in mice with adult T-cell leukemia/lymphoma. ( 27347156 )
2016
46
LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding. ( 26598604 )
2016
47
T Cell Receptor VI^ Staining Identifies the Malignant Clone in Adult T cell Leukemia and Reveals Killing of Leukemia Cells by Autologous CD8+ T cells. ( 27893842 )
2016
48
Functional Comparison of HBZ and the Related APH-2 Protein Provides Insight into Human T-Cell Leukemia Virus Type 1 Pathogenesis. ( 26819304 )
2016
49
Enhanced Stabilization of MCL1 by the Human T-Cell Leukemia Virus Type 1 bZIP Factor Is Modulated by Blocking the Recruitment of Cullin 1 to the SCF Complex. ( 27697867 )
2016
50
Human T-cell leukemia virus type 1-positive lymphomatoid papulosis. ( 26771231 )
2016

Variations for T-Cell Leukemia

Expression for T-Cell Leukemia

Search GEO for disease gene expression data for T-Cell Leukemia.

Pathways for T-Cell Leukemia

Pathways related to T-Cell Leukemia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 12.19 CDK6 CREB1 CRTC2 TCL1A TCL1B
2
Show member pathways
11.37 CREB1 CRTC2 SLC2A1
3 11.14 CREB1 CRTC2 SLC2A1
4 10.38 TLX1 TLX2 TLX3

GO Terms for T-Cell Leukemia

Biological processes related to T-Cell Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.85 GLI2 TAL1 TCL1A TLX1 TLX2 TLX3
2 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.17 CREB1 CRTC2 GLI2 LMO1 TAL1 TLX1
3 generation of neurons GO:0048699 9.16 CDK6 TAL1
4 regulation of hematopoietic stem cell differentiation GO:1902036 9.02 CDK6
5 positive regulation of protein oligomerization GO:0032461 8.96 PMAIP1
6 hematopoietic stem cell differentiation GO:0060218 8.96 CDK6 TAL1

Molecular functions related to T-Cell Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.1 CREB1 FOXN2 GLI2 TLX1 TLX2 TLX3

Sources for T-Cell Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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