T-PLL
MCID: TCL005
MIFTS: 42

T-Cell Prolymphocytic Leukemia (T-PLL) malady

Cancer diseases, Blood diseases, Immune diseases categories

Summaries for T-Cell Prolymphocytic Leukemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 T-cell-prolymphocytic leukemia (T-PLL) is a mature T-cell leukemia with aggressive behavior and... more...

MalaCards: T-Cell Prolymphocytic Leukemia, also known as t-cell chronic lymphocytic leukemia, is related to prolymphocytic leukemia and t-cell leukemia. An important gene associated with T-Cell Prolymphocytic Leukemia is CD19 (CD19 molecule), and among its related pathways are Apoptosis Pathway and PLK3 signaling events. The compounds neocarzinostatin and ricin have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and bone, and related mouse phenotypes are tumorigenesis and normal.

Aliases & Classifications for T-Cell Prolymphocytic Leukemia

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Sources:
48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
t-cell chronic lymphocytic leukemia:
Age of onset: Adulthood


Aliases & Descriptions:

t-cell prolymphocytic leukemia 48
t-cell chronic lymphocytic leukemia 48
prolymphocytic leukemia 60
t-pll 48


External Ids:

MESH via Orphanet35 D015461
ICD10 via Orphanet26 C91.3
SNOMED-CT via Orphanet57 128821006, 277567002
UMLS via Orphanet61 C2363142
ICD1025 C91.6

Related Diseases for T-Cell Prolymphocytic Leukemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the B Cell Prolymphocytic Leukemia family:

t-cell prolymphocytic leukemia

Diseases related to T-Cell Prolymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1prolymphocytic leukemia31.9MTCP1
2t-cell leukemia31.9ZAP70, ATM, MTCP1, NFKB1, CD7, TCL1A
3leukemia31.8ATM, MTCP1, CHEK2, ANPEP, NFKB1, IGKC
4sarcoma30.6TP53, SMARCB1, ETV6, ANPEP, CHEK2
5nijmegen breakage syndrome30.4ATM, CHEK2
6breast cancer30.4ATM, CHEK2
7hodgkin's lymphoma30.4MS4A1, TCL1A, ATM, ZAP70
8ataxia telangiectasia30.3ATM, MTCP1, CHEK2, TCL1A, TP53
9chronic lymphocytic leukemia30.3ZAP70, ATM, CD5, CD19, CD38, CD52
10acute leukemia30.3ATM, ANPEP, ETV6, CD7, SMARCB1
11macroglobulinemia30.1CD19, CD5
12myeloid leukemia30.1ANPEP, ETV6, CD38
13myeloma30.1ANPEP, IGKC, CD19, CD38, TCL1A
14acute lymphocytic leukemia30.1ZAP70, ANPEP, ETV6, CD5, CD19, CD38
15b cell prolymphocytic leukemia10.5
16hairy cell leukemia10.5
17diffuse large b-cell lymphoma10.4
18t-cell prolymphocytic leukemia, somatic10.4
19acute liver failure10.3
20acute t cell leukemia10.3
21t-cell large granular lymphocyte leukemia10.3
22panuveitis10.3
23t cell deficiency10.3
24vasculitis10.3
25pemphigus10.3
26malignant histiocytosis10.3
27megaloblastic anemia10.3
28histiocytosis10.3
29graft versus host disease10.2
30splenic manifestation of prolymphocytic leukemia10.2
31central nervous system leukemia10.2
32mantle cell lymphoma10.2
33meningitis10.2
34richter's syndrome10.1
35adult t-cell leukemia10.1
36leukostasis10.1
37lymphosarcoma10.1
38adult syndrome10.1
39adult lymphoma10.1
40exanthem10.1
41gingivitis10.1
42malignant mesothelioma10.1
43polyradiculoneuropathy10.1
44rhabdomyosarcoma10.1
45thrombocytopenia10.1
46arthritis10.0ANPEP
47hepatitis10.0ANPEP
48hepatitis c10.0HLA-S
49amyloidosis10.0IGKC
50laryngeal squamous cell carcinoma10.0TP53

Graphical network of the top 20 diseases related to T-Cell Prolymphocytic Leukemia:



Diseases related to t-cell prolymphocytic leukemia

Clinical Features for T-Cell Prolymphocytic Leukemia

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Drugs & Therapeutics for T-Cell Prolymphocytic Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for T-Cell Prolymphocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for T-Cell Prolymphocytic Leukemia

Search NIH Clinical Center for T-Cell Prolymphocytic Leukemia

Search CenterWatch for T-Cell Prolymphocytic Leukemia

Genetic Tests for T-Cell Prolymphocytic Leukemia

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Anatomical Context for T-Cell Prolymphocytic Leukemia

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32MalaCards
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MalaCards organs/tissues related to T-Cell Prolymphocytic Leukemia:

32
T cells, Bone marrow, Bone, Lymph node, Spleen, Liver, Skin

Animal Models for T-Cell Prolymphocytic Leukemia or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to T-Cell Prolymphocytic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6CHEK2, ETV6, CD19, CDKN1B, SMARCB1
2MP:00028738.3TP53, CD52, CD19, CD5, ETV6, NFKB1
3MP:00053846.6CD19, TP53, SMARCB1, MS4A1, CDKN1B, CD7
4MP:00053976.5TP53, ATM, CHEK2, ANPEP, NFKB1, IGKC
5MP:00053876.4ZAP70, SMARCB1, MS4A1, CDKN1B, CD7, CD38

Publications for T-Cell Prolymphocytic Leukemia

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Genetic Variations for T-Cell Prolymphocytic Leukemia

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Expression for genes affiliated with T-Cell Prolymphocytic Leukemia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with T-Cell Prolymphocytic Leukemia

Search GEO for disease gene expression data for T-Cell Prolymphocytic Leukemia.

Pathways for genes affiliated with T-Cell Prolymphocytic Leukemia

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Sources:
59Tocris Bioscience, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 51QIAGEN, 29KEGG, 49PharmGKB
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Pathways related to T-Cell Prolymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2ATM
210.0TP53, CHEK2
3
Hide members
10.0CHEK2, ATM
49.8ATM, CHEK2, TP53
5
Cell cycle Role of 14-3-3 proteins in cell cycle regulation
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9.8TP53, CHEK2, ATM
6
DNA damage Role of Brca1 and Brca2 in DNA repair
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9.8CHEK2, ATM, TP53
79.8CHEK2, TP53, ATM
89.8CHEK2, TP53, ATM
9
Hide members
9.8CHEK2, TP53, ATM
10
Hide members
9.8ATM, CDKN1B, TP53
119.8ATM, CDKN1B, TP53
12
Hide members
9.8TP53, NFKB1, CHEK2
139.7ZAP70, ATM, NFKB1
14
Transcription P53 signaling pathway
Hide members
9.7TP53, ATM, NFKB1
15
Hide members
9.7NFKB1, CDKN1B, TP53
169.7NFKB1, CDKN1B, TP53
17
Hide members
9.7CDKN1B, TP53, NFKB1
18
Hide members
9.7TP53, CDKN1B, NFKB1
19
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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9.7TP53, CDKN1B, NFKB1
209.7ATM, CDKN1B, NFKB1
21
Immune response NFAT in immune response
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9.7ZAP70, NFKB1, IGKC
22
Hide members
9.5ATM, TP53, CDKN1B, CHEK2
23
Hide members
9.5TP53, CDKN1B, CHEK2, ATM
249.5ATM, TP53, CHEK2, SMARCB1
259.5TP53, NFKB1, CHEK2, ATM
269.5TP53, NFKB1, CHEK2, ATM
279.5CHEK2, TP53, NFKB1, ATM
28
Hide members
9.5ZAP70, NFKB1, CD19, IGKC
299.5NFKB1, ATM, CDKN1B, TP53
30
Hide members
9.5NFKB1, ATM, TP53, CDKN1B
31
Hide members
9.5TP53, CDKN1B, NFKB1, ATM
32
Hide members
9.4CD19, IGKC, NFKB1, CDKN1B
33
Hide members
9.4CD19, CDKN1B, NFKB1, IGKC
349.4TP53, CD19, NFKB1, CDKN1B, CD38
35
Hide members
9.3ZAP70, ATM, CHEK2, TP53, NFKB1
369.3CDKN1B, ATM, CHEK2, NFKB1, TP53
37
Hide members
9.1CDKN1B, TP53, CHEK2, ZAP70, ATM, NFKB1
389.0ANPEP, CD5, CD19, CD38, CD7, MS4A1
398.9TP53, ATM, NFKB1, ETV6, CDKN1B
408.8MTCP1, NFKB1, CD19, CDKN1B, TCL1A, TP53

Compounds for genes affiliated with T-Cell Prolymphocytic Leukemia

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to T-Cell Prolymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1neocarzinostatin4410.3CHEK2, ATM
2ricin4410.1CD19, CD5
3bpde4410.1CHEK2, ATM, TP53
4gemcitabine44 49 1111.9TP53, CDKN1B, CHEK2
5hydroxyurea44 49 1111.9ATM, TP53, CHEK2
6aphidicolin449.9TP53, CDKN1B, CHEK2, ATM
7camptothecin44 59 1111.8TP53, CDKN1B, CHEK2, ATM
8n acetylcysteine449.8ATM, CHEK2, CDKN1B, TP53
9rituximab44 49 1111.7CD38, ZAP70, CD52, MS4A1
10cytarabine44 49 1111.7ATM, CDKN1B, TP53
11cyclophosphamide44 49 1111.6ZAP70, HLA-S, TP53, MS4A1, CDKN1B
12etoposide44 49 59 1112.6ATM, CDKN1B, TP53, NFKB1, CHEK2
13phosphatidylinositol449.4ZAP70, ATM, CHEK2, CD19, CDKN1B, CD38
14paraffin449.4CD5, MS4A1, TP53, ANPEP, ATM, CDKN1B
15doxorubicin44 49 1111.4ANPEP, CHEK2, CD19, CDKN1B, TP53, ATM
16serine449.4TCL1A, CDKN1B, ANPEP, CHEK2
17oligonucleotide449.3ANPEP, CHEK2, ZAP70, CDKN1B, TP53
18fludarabine44 1110.3CD38, TP53, MS4A1, CD52, CDKN1B, ZAP70
19atp44 2810.2CHEK2, ATM, ZAP70, ANPEP, CDKN1B, CD38
20wortmannin449.1ATM, CDKN1B, ANPEP, CHEK2
21threonine449.1CDKN1B, CHEK2, ATM, ZAP70, ANPEP, TCL1A
22retinoic acid44 249.9ETV6, CHEK2, ANPEP, CD38, CDKN1B, TP53
23tyrosine448.4ZAP70, ANPEP, CDKN1B, CD38, CD19, CD5

GO Terms for genes affiliated with T-Cell Prolymphocytic Leukemia

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16Gene Ontology
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Cellular components related to T-Cell Prolymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3ANPEP, CD5, CD19, MS4A1
2nucleoplasmGO:0056549.0ATM, CHEK2, NFKB1, CDKN1B, SMARCB1, TP53

Biological processes related to T-Cell Prolymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1DNA damage induced protein phosphorylationGO:00697510.1ATM, CHEK2
2replicative senescenceGO:09039910.0ATM, CHEK2, TP53
3DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.8CDKN1B, ATM, TP53
4double-strand break repairGO:0063029.7TP53, CHEK2, ATM, BRCC3
5mitotic cell cycle arrestGO:0718509.7TP53, CDKN1B
6Fc-epsilon receptor signaling pathwayGO:0380959.6CDKN1B, NFKB1, IGKC, CD19
7immune responseGO:0069559.3ZAP70, IGKC, CD7, MS4A1
8negative regulation of apoptotic processGO:0430669.2ATM, NFKB1, CD38, CDKN1B, TP53

Products for genes affiliated with T-Cell Prolymphocytic Leukemia

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for T-Cell Prolymphocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet