T-cell Prolymphocytic Leukemia malady

Wikipedia: T-cell-prolymphocytic leukemia (T-PLL) is a mature T-cell leukemia with aggressive behavior and...⁴⁴ more...

MalaCards: T-cell Prolymphocytic Leukemia, also known as leukemia, t-cell, chronic, is related to prolymphocytic leukemia and ataxia telangiectasia. An important gene associated with T-cell Prolymphocytic Leukemia is ATM (ataxia telangiectasia mutated), and among its related pathways are DNA damage DNA-damage-induced responses and G2/M DNA damage checkpoint. The compounds cyclophosphamide and neocarzinostatin have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spleen, and related mouse phenotypes are digestive/alimentary and no phenotypic analysis.

t-cell prolymphocytic leukemia 7 leukemia, t-cell, chronic 43

Disease types for t-cell prolymphocytic leukemia family:

b cell prolymphocytic leukemia

Diseases related to t-cell prolymphocytic leukemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 209)

id	Related Disease	Score	Top Affiliating Genes
1	prolymphocytic leukemia	35.5	ZAP70, MTCP1, ATM, CD5, CD38, ANPEP
2	ataxia telangiectasia	30.0	BRCC3, CHEK2, MTCP1, ATM, TP53, TCL1A
3	leukemia	27.2	BRCC3, VEGFA, CHEK2, ZAP70, MTCP1, MS4A1
4	cll/sll	13.5	ZAP70, ATM
5	richter's syndrome	13.4	ATM, CD5, CD38
6	familial chronic lymphocytic leukemia	13.4	ATM, CD38, ANPEP
7	cerebrum cancer	13.3	TP53, SMARCB1
8	breast cancer	13.3	CHEK2, ATM
9	li-fraumeni syndrome	13.2	CHEK2, ATM, TP53
10	bilateral breast cancer	13.2	CHEK2, ATM, TP53
11	sturge-weber syndrome	13.2	VEGFA, TP53
12	hereditary breast ovarian cancer	13.2	CHEK2, TP53
13	choroid plexus carcinoma	13.1	TP53, SMARCB1
14	burkitt's lymphoma	13.1	ZAP70, MS4A1, CD38, TCL1A
15	splenomegaly	13.1	VEGFA, ATM, CD5
16	female breast cancer	13.1	ATM, CDKN1B, TP53
17	bloom syndrome	13.0	CHEK2, ATM, TP53
18	skin papilloma	13.0	VEGFA, TP53
19	pre-b-cell acute lymphoblastic leukemia	13.0	ZAP70, ETV6, TCL1A
20	periampullary adenocarcinoma	13.0	VEGFA, CDKN1B
21	barrett's adenocarcinoma	13.0	VEGFA, ANPEP, TP53
22	maxillary sinus squamous cell carcinoma	12.9	VEGFA, TP53
23	lymphatic system disease	12.8	MS4A1, CD5, IL2
24	waldenstrom macroglobulinemia	12.8	VEGFA, ZAP70, MS4A1, CD52
25	anaplastic meningioma	12.8	VEGFA, CDKN1B, TP53
26	colorectal adenoma and carcinoma	12.7	VEGFA, CHEK2, TP53
27	cutaneous t cell lymphoma	12.7	CD5, IL2, ANPEP
28	thyroid cancer, follicular	12.7	VEGFA, CDKN1B, TP53
29	follicular lymphoma	12.7	ZAP70, MS4A1, CDKN1B, CD5, TCL1A
30	agammaglobulinemia	12.7	CD19, CD38, IL2
31	amyloidosis	12.7	ANPEP, IGKC, TP53, NFKB1
32	breast cancer susceptibility	12.6	VEGFA, CHEK2, ATM, TP53
33	peripheral t-cell lymphoma	12.6	ZAP70, MS4A1, CD5, ETV6, TCL1A
34	reactive arthritis	12.6	IL2, ANPEP, TP53
35	malt lymphoma	12.6	ZAP70, CDKN1B, CD19, CD5, IGKC, TP53
36	pemphigus	12.5	MS4A1, CD19, IL2, TP53
37	connective tissue disease	12.5	CD19, CD5, IL2, TP53
38	extramedullary plasmacytoma	12.5	VEGFA, IL2, IGKC
39	lymphopenia	12.5	ZAP70, ATM, CD52, IL2
40	acute lymphoblastic leukemia, childhood	12.5	CDKN1B, ETV6
41	inflammatory breast cancer	12.5	CDKN1B, TP53, NFKB1
42	leukopenia	12.5	CD52, CD19, CD5, IL2
43	thymoma	12.5	MS4A1, CD5, IL2, TP53
44	ovarian mucinous neoplasm	12.4	CHEK2, TP53, NFKB1
45	nijmegen breakage syndrome	12.4	CHEK2, ATM, IL2, TP53
46	breast adenocarcinoma	12.4	VEGFA, CHEK2, CDKN1B, TP53
47	b cell prolymphocytic leukemia	12.4	ZAP70, MS4A1, CD19, CD5, CD38, ANPEP
48	neuroendocrine carcinoma	12.4	VEGFA, CHEK2, CDKN1B, TP53
49	diffuse infiltrative lymphocytosis syndrome	12.4	ZAP70, MS4A1, CD5, CD38, IL2
50	mycosis fungoides	12.4	CD7, IL2, ANPEP, TP53

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to t-cell prolymphocytic leukemia:

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MGI Mouse Phenotypes related to t-cell prolymphocytic leukemia:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary phenotype	MP:0005381	8.9	VEGFA, SMARCB1, ETV6, CD19
2	no phenotypic analysis	MP:0003012	8.3	TP53, CDKN1B, CD5, IGKC, ETV6, ATM
3	reproductive system phenotype	MP:0005389	8.0	CDKN1B, SMARCB1, ETV6, TCL1A, VEGFA, ANPEP
4	normal phenotype	MP:0002873	7.7	CD5, VEGFA, NFKB1, TP53, ETV6, CD19
5	tumorigenesis	MP:0002006	7.4	IL2, CHEK2, ATM, CDKN1B, CD19, SMARCB1
6	liver/biliary system phenotype	MP:0005370	6.9	VEGFA, CDKN1B, CD19, IL2, TP53, SMARCB1
7	immune system phenotype	MP:0005387	6.7	ETV6, ANPEP, SMARCB1, TP53, CHEK2, ZAP70
8	hematopoietic system phenotype	MP:0005397	5.0	IGKC, TP53, SMARCB1, NFKB1, ZAP70, ANPEP
9	cellular phenotype	MP:0005384	4.9	CD38, IL2, ETV6, TP53, SMARCB1, NFKB1

Articles related to t-cell prolymphocytic leukemia:

(show all 24)

id	Title	Authors	Year	Affiliating Genes
1	CD5-positive B-cell prolymphocytic leukemia (20134145)	Inoue T.... Yoshida T.	2010	CD5
2	Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomy. (19278963)	Nowak D.... Koeffler H.P.	2009	ATM
3	Recurrent loss, but lack of mutations, of the SMARCB1 tumor suppressor gene in T-cell prolymphocytic leukemia with TCL1A-TCRAD juxta position. (19480937)	Bug S.... Siebert R.	2009	CHEK2, SMARCB1, TCL1A
4	High TCL1 expression and intact T-cell receptor signaling define a hyperproliferative subset of T-cell prolymphocytic leukemia. (17890451)	Herling M.... Jones D.	2008	TCL1A
5	Haploinsufficiency of CDKN1B contributes to leukemogenesis in T-cell prolymphocytic leukemia. (18073348)	Le Toriellec E.... Stern M.H.	2008	ATM, CDKN1B
6	Complex karyotype including chromosomal translocation (8;14) (q24;q32) in one case with B-cell prolymphocytic leukemia. (16997373)	Crisostomo R.H.... Caceres W.	2007	IGKC
7	Production of vascular endothelial growth factor in T-cell prolymphocytic leukemia. (16620970)	Ogasawara T.... Kawauchi K.	2007	VEGFA
8	IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL). (16642047)	Del Giudice I.... Catovsky D.	2006	ZAP70, CD38
9	T-cell prolymphocytic leukemia. (16645226)	Dearden C.E.	2006	CD52
10	T cell prolymphocytic leukemia with new chromosome rearrangements. (15034240)	Zver S.... Cernelc P.	2004	CD7
11	CD3-negative, CD20-positive T-cell prolymphocytic leukemia: case report and review of the literature. (12447967)	Tamayose K.... Oshimi K.	2002	MS4A1
12	A complex pattern of recurrent chromosomal losses and gains in T-cell prolymphocytic leukemia. (11391795)	Soulier J.... Aurias A.	2001	ATM
13	Transgenic mice expressing MTCP1: an animal model for T-cell prolymphocytic leukemia (10669814)	Chiali-Gritti C.	2000	TCL1A, MTCP1
14	Abnormalities of the short arm of chromosome 12 in T cell prolymphocytic leukemia. (9639428)	Salomon-Nguyen F.... Brizard A.	1998	ETV6
15	Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology. (9519406)	Hoh F.... van Tilbourgh H.	1998	TCL1A, MTCP1
16	Inactivation of the ATM gene in T-cell prolymphocytic leukemias. (9573030)	Stoppa-Lyonnet D.... Stern M.-H.	1998	ATM
17	Transgenic mice for MTCP1 develop T-cell prolymphocytic leukemia. (9657733)	Gritti C.... Stern M.H.	1998	TCL1A, MTCP1
18	IL-2-induced growth of CD8+ T cell prolymphocytic leukemia cells mediated by NF-kappaB induction and IL-2 receptor alpha expression. (9619918)	Arima N.... Tanaka H.	1998	NFKB1, IL2
19	p53 abnormalities in B-cell prolymphocytic leukemia. (9058723)	Lens D.... Catovsky D.	1997	TP53
20	Perforin-positive leukemic cell infiltration in the aortic tissue of a patient with T-cell prolymphocytic leukemia. (8971584)	Seko Y.... Yazaki Y.	1996	HLA-S
21	B-cell prolymphocytic leukemia expressing discordant myeloid-associated antigens in simultaneous specimens from bone marrow and peripheral blood. (8556956)	Emery C.L.... Cleveland R.P.	1995	ANPEP
22	Perforin-positive leukemic cell infiltration in the heart of a patient with T-cell prolymphocytic leukemia. (8563121)	Seko Y.... Yazaki Y.	1995	HLA-S
23	A gene on chromosome Xq28 associated with T-cell prolymphocytic leukemia in two patients with ataxia telangiectasia. (8152252)	Thick J.... Taylor A.M.	1994	BRCC3, MTCP1
24	B-cell prolymphocytic leukemia expressing CD13 antigen. (7524729)	Matsushita A.... Takahashi T.	1994	ANPEP, CD19, MS4A1

Genes related to t-cell prolymphocytic leukemia according to GeneCards:

(show all 22)

id	Symbol	Description	Score	GeneCards Section Context
1	ATM	ataxia telangiectasia mutated	11.0	Publications
2	IGKC	immunoglobulin kappa constant	11.0	Publications
3	MS4A1	membrane-spanning 4-domains, subfamily A, member 1	11.0	Publications
4	CD5	CD5 molecule	11.0	Publications
5	CD19	CD19 molecule	11.0	Publications
6	ANPEP	alanyl (membrane) aminopeptidase	11.0	Publications
7	ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	11.0	Publications
8	CD38	CD38 molecule	11.0	Publications
9	TP53	tumor protein p53	11.0	Publications
10	MTCP1	mature T-cell proliferation 1	11.0	Publications, Functions
11	TCL1A	T-cell leukemia/lymphoma 1A	11.0	Publications
12	HLA-S	major histocompatibility complex, class I, S (pseudogene)	11.0	Publications
13	CD52	CD52 molecule	11.0	Publications
14	CD7	CD7 molecule	11.0	Publications
15	BRCC3	BRCA1/BRCA2-containing complex, subunit 3	11.0	Publications
16	SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	11.0	Publications
17	CHEK2	checkpoint kinase 2	11.0	Publications
18	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	11.0	Publications
19	ETV6	ets variant 6	11.0	Publications
20	NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	11.0	Publications
21	IL2	interleukin 2	11.0	Publications
22	VEGFA	vascular endothelial growth factor A	11.0	Publications

Pathways related to t-cell prolymphocytic leukemia according to GeneDecks:

(show all 31)

id	Pathway	Score	Top Affiliating Genes
1	DNA damage DNA-damage-induced responses10	10.3	CHEK2, ATM
2	G2/M DNA damage checkpoint38	10.1	CHEK2, ATM
3	Transcription P53 signaling pathway10	10.1	TP53, VEGFA
4	DNA damage_DNA-damage-induced responses41	10.0	CHEK2, ATM, TP53
5	Cell cycle_Role of 14-3-3 proteins in cell cycle regulation41	10.0	ATM, TP53, CHEK2
6	Cell cycle Role of 14-3-3 proteins in cell cycle regulation10	10.0	ATM, TP53, CHEK2
7	DNA damage_Role of Brca1 and Brca2 in DNA repair41	10.0	TP53, ATM, CHEK2
8	DNA damage Role of Brca1 and Brca2 in DNA repair10	10.0	CHEK2, TP53, ATM
9	ATM Pathway36	9.9	CHEK2, ATM, TP53
10	G2-M Phase Transition36	9.9	TP53, ATM, CHEK2
11	G1-S Phase Transition36	9.9	ATM, TP53, CDKN1B
12	Chks in Checkpoint Regulation36	9.9	TP53, ATM, CHEK2
13	p53 signaling pathway20	9.8	TP53, ATM, CHEK2
14	Cyclins and Cell Cycle Regulation36	9.8	CDKN1B, TP53, ATM
15	BRCA1 Pathway36	9.6	TP53, ATM, SMARCB1, CHEK2
16	DNA Damage3	9.6	ATM, CHEK2, TP53
17	Cell cycle20	9.5	CHEK2, ATM, CDKN1B, TP53
18	Hematopoietic cell lineage20	9.5	MS4A1, ANPEP, CD38, CD7, CD5, CD19
19	Immune response_BCR pathway41	9.5	NFKB1, IGKC, CD19
20	DNA damage ATM/ATR regulation of G1/S checkpoint10	9.4	ATM, CHEK2, NFKB1, TP53
21	DNA damage_ATM/ATR regulation of G1/S checkpoint41	9.4	NFKB1, ATM, CHEK2, TP53
22	Cell Cycle / Checkpoint Control3	9.4	CHEK2, ATM, CDKN1B, TP53
23	Signal transduction_AKT signaling41	9.4	NFKB1, TP53, CDKN1B
24	Transcription_P53 signaling pathway41	9.3	TP53, NFKB1, ATM, VEGFA
25	Immune response BCR pathway10	9.2	CD19, NFKB1, IGKC
26	Chronic myeloid leukemia20	9.2	CDKN1B, NFKB1, TP53
27	p53 Mediated Apoptosis36	9.1	IL2, CHEK2, TP53, ATM
28	Mitochondrial Apoptosis36	9.1	IL2, TP53, ATM, CHEK2
29	Measles20	8.7	NFKB1, TP53, CDKN1B, IL2
30	Cellular Apoptosis Pathway36	8.6	CHEK2, NFKB1, TP53, IL2, ATM
31	Molecular Mechanisms of Cancer36	7.8	NFKB1, TP53, CHEK2, ATM, CDKN1B, IL2

Compounds related to t-cell prolymphocytic leukemia according to GeneDecks:

(show all 30)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.6	MS4A1
2	neocarzinostatin32	10.2	CHEK2, ATM
3	bpde32	10.0	TP53, CHEK2, ATM
4	topotecan32 9 9	11.8	TP53, ATM, VEGFA
5	aphidicolin32	9.6	CDKN1B, TP53, ATM, CHEK2
6	etoposide32 42 9 9	12.5	TP53, CHEK2, ATM, CDKN1B
7	camptothecin32 42 9 9	12.5	CHEK2, ATM, CDKN1B, TP53
8	flavopiridol32 9 9	11.4	CDKN1B, VEGFA, TP53
9	doxorubicin32 34 9 9	12.4	CD19, CDKN1B, TP53, CHEK2, ATM
10	bucillamine32	9.2	IL2, VEGFA
11	triptolide32	9.2	VEGFA, IL2, TP53
12	gemcitabine32 34 9 9	12.2	TP53, CDKN1B, CHEK2, VEGFA
13	piclamilast32 9 9	11.1	IL2, VEGFA
14	rituximab32 34 9 9	12.1	MS4A1, CD52, CD38, ZAP70, IL2
15	imatinib32 34 9 9	12.0	VEGFA, ZAP70, CDKN1B, ETV6
16	rapamycin32 42	10.0	VEGFA, IL2, CHEK2
17	n acetylcysteine32	9.0	TP53, ATM, CHEK2, VEGFA, CDKN1B
18	paraffin32	8.9	TP53, ANPEP, CDKN1B, CD5, VEGFA, MS4A1
19	temozolomide32 9 9	10.9	VEGFA, TP53, IL2, CHEK2
20	trastuzumab32 34 9 9	11.8	IL2, VEGFA, CDKN1B
21	thalidomide32 42 9 9	11.7	NFKB1, IL2, VEGFA
22	phosphatidylinositol32	8.5	CDKN1B, ATM, CD19, ZAP70, CD38, CHEK2
23	fludarabine32 9 9	10.4	ZAP70, MS4A1, CDKN1B, CD52, CD38, IL2
24	actinomycin d32	8.3	TP53, VEGFA, CDKN1B, CD38, IL2, ANPEP
25	5fluorouracil32	8.3	CDKN1B, TP53, IL2, VEGFA
26	genistein32 9 18 9	11.2	CDKN1B, CHEK2, ZAP70, ATM, IL2, VEGFA
27	dexamethasone32 42 34 9 9	12.2	IL2, ZAP70, VEGFA, ANPEP, CDKN1B, CD38
28	cisplatin32 34 9 9	11.2	VEGFA, TP53, IL2, CDKN1B, ATM, CHEK2
29	serine32	7.7	ZAP70, CHEK2, CDKN1B, IL2, ANPEP, TP53
30	tyrosine32	6.9	VEGFA, CHEK2, ETV6, IL2, CD38, CD5

Biological processes related to t-cell prolymphocytic leukemia according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	replicative senescence	GO:090399	9.8	TP53, ATM, CHEK2
2	DNA damage induced protein phosphorylation	GO:006975	9.8	CHEK2, ATM
3	mitotic cell cycle arrest	GO:071850	9.8	CDKN1B, TP53
4	double-strand break repair	GO:006302	9.5	TP53, ATM, CHEK2, BRCC3
5	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO:006977	9.3	TP53, CDKN1B, ATM
6	cell cycle checkpoint	GO:000075	9.3	CHEK2, ATM, CDKN1B, TP53
7	negative regulation of apoptotic process	GO:043066	9.0	TP53, CD38, CDKN1B, ATM, VEGFA
8	immune response	GO:006955	8.7	MS4A1, IGKC, IL2, CD7, ZAP70