MCID: TLY001
MIFTS: 40

T Lymphocyte Deficiency malady

Immune diseases category

Summaries for T Lymphocyte Deficiency

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MalaCards: T Lymphocyte Deficiency, also known as t-lymphocyte immunodeficiency, is related to thyroiditis and progressive multifocal leukoencephalopathy. An important gene associated with T Lymphocyte Deficiency is GATA2 (GATA binding protein 2), and among its related pathways are Primary immunodeficiency and Immune response Antigen presentation by MHC class II. The compounds 9-(beta-d-arabinofuranosyl)guanine and nelarabine have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone marrow, and related mouse phenotypes are cellular and homeostasis/metabolism.

Aliases & Classifications for T Lymphocyte Deficiency

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

t lymphocyte deficiency 8 10
t-lymphocyte immunodeficiency 8 60
t-lymphocyte deficiency 8 60
t-cell immunodeficiency 8


External Ids:

Disease Ontology8 DOID:613
SNOMED-CT56 402792003
NCIt39 C27145

Related Diseases for T Lymphocyte Deficiency

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17GeneCards, 18GeneDecks
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Diseases related to T Lymphocyte Deficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 37)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.3CD4
2progressive multifocal leukoencephalopathy30.2CD4
3t-cell immunodeficiency, congenital alopecia and nail dystrophy10.5
4t cell immunodeficiency primary10.3
5ectodermal dysplasia, anhidrotic, with t-cell immunodeficiency10.3
6t-cell immunodeficiency, recurrent infections, autoimmunity, and cardiac malformations10.3
7t-cell immunodeficiency with epidermodysplasia verruciformis10.3
8nezelof syndrome10.2
9immune defect due to absence of thymus10.2
10purine nucleoside phosphorylase deficiency10.2
11alopecia and t-cell immunodeficiency10.2
12vaccinia10.0
13down syndrome10.0
14graves' disease10.0
15t cell deficiency10.0
16pure red-cell aplasia10.0
17dyskeratosis congenita10.0
18autoimmune thrombocytopenic purpura10.0
19molluscum contagiosum10.0
20cartilage-hair hypoplasia10.0
21eosinophilia10.0
22purpura10.0
23charge syndrome10.0
24lymphopenia10.0PNP
25severe combined immunodeficiency10.0RAG2, PNP, CD3G
26hematologic cancer10.0DGUOK, GATA2, PNP
27arthritis10.0RAG2, CD4
28chediak-higashi syndrome10.0RAB27A, LYST
29primary immunodeficiency disease10.0PNP, CD4
30precursor t-cell acute lymphoblastic leukemia10.0PNP, GATA2, CD4
31herpes simplex10.0PNP, CD4, DGUOK
32chronic lymphocytic leukemia10.0PNP, CD4, DGUOK
33t-cell leukemia10.0CD4, RAG2, PNP
34malignant glioma10.0XRCC5, CD4, RNASE1, PNP
35melanoma10.0PNP, RAB27A, RNASE1, CD4, XRCC5
36ipex syndrome10.0CD3G, CD4, RNASE1, DGUOK, RAB27A, PNP
37leukemia10.0PNP, RNASE1, DGUOK, RAG2, XRCC5, CD4

Graphical network of the top 20 diseases related to T Lymphocyte Deficiency:



Diseases related to t lymphocyte deficiency

Clinical Features for T Lymphocyte Deficiency

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Drugs & Therapeutics for T Lymphocyte Deficiency

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for T Lymphocyte Deficiency

Genetic Tests for T Lymphocyte Deficiency

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Anatomical Context for T Lymphocyte Deficiency

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32MalaCards
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MalaCards organs/tissues related to T Lymphocyte Deficiency:

32
T cells, B cells, Bone marrow, Bone, Thyroid, Thymus

Animal Models for T Lymphocyte Deficiency or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to T Lymphocyte Deficiency:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.5XRCC5, GATA2, CD3G, CD4, RAG2, RAB27A
2MP:00053767.3GATA2, CD4, RAG2, RAB27A, PNP, SRSF4
3MP:00053877.1XRCC5, CD3G, CD4, RAG2, RAB27A, PNP
4MP:00053977.0LYST, XRCC5, GATA2, CD3G, CD4, RAG2

Publications for T Lymphocyte Deficiency

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50PubMed
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Articles related to T Lymphocyte Deficiency:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus. (23269247)
2013
2
NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells. (22412192)
2012
3
STIM1 and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjogren's syndrome. (22904194)
2012
4
Arginine deficiency leads to impaired cofilin dephosphorylation in activated human T lymphocytes. (22345165)
2012
5
Progressive multifocal leukoencephalopathy associated with mycophenolate mofetil treatment in a woman with lupus and CD4+ T-lymphocyte deficiency. (21976399)
2012
6
Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus. (22496215)
2012
7
Progressive multifocal leukoencephalopathy associated with isolated CD8+ T-lymphocyte deficiency mimicking tumefactive MS. (21786075)
2011
8
Deficiency of activated STAT1 in head and neck cancer cells mediates TAP1-dependent escape from cytotoxic T lymphocytes. (21207025)
2011
9
Nonhealing wound due to Rhodococcus equi in an apparently immunocompetent patient, revealing CD8+ T-lymphocyte deficiency. (20881171)
2010
10
Expression of chemokine receptors CXCR4, CXCR5 and CCR7 on B and T lymphocytes from patients with primary antibody deficiency. (19250276)
2009
11
Perforin-dependent apoptosis functionally compensates Fas deficiency in activation-induced cell death of human T lymphocytes. (17724145)
2007
12
T and B lymphocyte subpopulations and activation/differentiation markers in patients with selective IgA deficiency. (17223965)
2007
13
Complement-dependent enhancement of CD8+ T cell immunity to lymphocytic choriomeningitis virus infection in decay-accelerating factor-deficient mice. (17709533)
2007
14
Perforin-deficient CD8+ T cells mediate fatal lymphocytic choriomeningitis despite impaired cytokine production. (16414999)
2006
15
Essential roles of perforin in antigen-specific cytotoxicity mediated by human CD4+ T lymphocytes: analysis using the combination of hereditary perforin-deficient effector cells and Fas-deficient target cells. (12574394)
2003
16
Adenosine deaminase deficiency with mosaicism for a "second-site suppressor" of a splicing mutation: decline in revertant T lymphocytes during enzyme replacement therapy. (11807006)
2002
17
Wound healing and growth factor expression in T lymphocyte deficiency. (12123510)
2002
18
Specific deficiency of p56lck expression in T lymphocytes from type 1 diabetic patients. (11067948)
2000
19
Towards metabolic sink therapy for mut methylmalonic acidaemia: correction of methylmalonyl-CoA mutase deficiency in T lymphocytes from a mut methylmalonic acidaemia child by retroviral-mediated gene transfer. (10518277)
1999
20
Incomplete T-cell immune reconstitution in two major histocompatibility complex class II-deficiency/bare lymphocyte syndrome patients after HLA-identical sibling bone marrow transplantation. (10381532)
1999
21
High-efficiency gene transfer into normal and adenosine deaminase-deficient T lymphocytes is mediated by transduction on recombinant fibronectin fragments. (9573255)
1998
22
T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates. (9662367)
1998
23
Cell-cycle arrest and apoptosis hypersusceptibility as a consequence of Lck deficiency in nontransformed T lymphocytes. (9770514)
1998
24
Virus-specific, CD8+ major histocompatibility complex class I-restricted cytotoxic T lymphocytes in lymphocytic choriomeningitis virus-infected beta2-microglobulin-deficient mice. (9343195)
1997
25
Phenotypic features of selective T cell deficiency characterized by absence of CD8+ T lymphocytes and undetectable mRNA for ZAP-70 kinase. (9245543)
1997
26
T-cell-mediated immunity to lymphocytic choriomeningitis virus in beta2-integrin (CD18)- and ICAM-1 (CD54)-deficient mice. (8971031)
1996
27
T-lymphocyte differentiation and proliferation in the absence of the cytoplasmic tail of the common cytokine receptor gamma c chain in a severe combined immune deficiency X1 patient. (8781427)
1996
28
Molecular analysis of T lymphocyte-directed gene therapy for adenosine deaminase deficiency: long-term expression in vivo of genes introduced with a retroviral vector. (8773514)
1996
29
Enhanced susceptibility to human immunodeficiency virus infection in CD4+ T lymphocytes genetically deficient in CD43. (8554898)
1995
30
Correction of proliferative responses in purine nucleoside phosphorylase (PNP)-deficient T lymphocytes by retroviral-mediated PNP gene transfer and expression. (7876563)
1995
31
Clinical consequences and treatment of primary immunodeficiency syndromes characterized by functional T and B lymphocyte anomalies (combined immune deficiency). (8121739)
1994
32
T lymphocyte ontogeny in adenosine deaminase-deficient severe combined immune deficiency after treatment with polyethylene glycol-modified adenosine deaminase. (8349799)
1993
33
Regulation of mucosal immune responses by T lymphocytes: the effect of chronic CD4+ T cell deficiency on IgA synthesis. (1354470)
1992
34
Defective T-lymphocyte signal transduction and function in leukocyte adhesion deficiency. (1918265)
1991
35
Exogenous interleukin 2 (IL 2) reconstitutes deficient in vitro T-cell growth of patients with chronic lymphocytic leukemia of B-cell lineage (B-CLL). (2382990)
1990
36
Reconstitution of T- and B-cell function after T-lymphocyte-depleted haploidentical bone marrow transplantation in severe combined immunodeficiency due to adenosine deaminase deficiency. (3304740)
1987
37
Interleukin 2 liberation and absorption capacities of rat T lymphocytes in conditions of severe adenylic nucleotide pool depletion due to adenosine deaminase deficiency. (3877709)
1985
38
Autologous mixed lymphocyte reaction in man. XI. Deficiency of autologous mixed lymphocyte reaction and abnormalities of monoclonal antibody-defined T-cell subsets in chronic mucocutaneous candidiasis. (2992070)
1985
39
The Omenn's syndrome: histological, immunohistochemical and ultrastructural evidence for a partial T cell deficiency evolving in an abnormal proliferation of T lymphocytes and S-100 +/T-6 + Langerhans-like cells. (3925627)
1985
40
Suppressor T-lymphocyte deficiency in Graves' disease and Hashimoto's thyroiditis. (6450775)
1981
41
Phosphorylation of deoxyguanosine by B and T lymphocytes: evidence against selective trapping of deoxyguanosine by T lymphocytes in purine nucleoside phosphorylase deficiency. (6783354)
1980
42
Multi-system immunologically mediated disease: T lymphocyte deficiency and thyroid immunologic disease--a report of four cases. (308799)
1978
43
Impaired defense against vaccinia in a child with T-lymphocyte deficiency associated with inosine phosphorylase defect. (416187)
1978
44
Pyridoxine deficiency and cytotoxicity of T lymphocytes in vitro. (149594)
1978
45
Thymus-dependent (T) lymphocyte deficiency in progressive systemic sclerosis. (1086678)
1976
46
Familial dysequilibrium-diplegia with T-lymphocyte deficiency. (1083213)
1975
47
T-Lymphocyte deficiency following adult thymectomin man. (1079964)
1975
48
The effect of T lymphocyte deficiency on tumor induction and growth. (1104194)
1975
49
Lack of suppression of certain immunoglobulin-producing lymphocytes in T-lymphocyte deficiency. (4215606)
1974
50
Restoration of T-lymphocyte deficiency with dialysable leucocyte extract. (4549704)
1974

Genetic Variations for T Lymphocyte Deficiency

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Expression for genes affiliated with T Lymphocyte Deficiency

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with T Lymphocyte Deficiency

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Pathways for genes affiliated with T Lymphocyte Deficiency

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29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 4Cell Signaling Technology
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Pathways related to T Lymphocyte Deficiency according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8RAG2, CD4
2
Immune response Antigen presentation by MHC class II
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9.8CD4, CD3G
39.8CD3G, CD4
4
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9.6CD4, XRCC5
59.4CD4, GATA2, XRCC5

Compounds for genes affiliated with T Lymphocyte Deficiency

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44Novoseek, 11DrugBank, 24HMDB
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Compounds related to T Lymphocyte Deficiency according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
19-(beta-d-arabinofuranosyl)guanine4410.1PNP, DGUOK
2nelarabine44 1111.1DGUOK, PNP
3deoxyadenosine44 2411.0DGUOK, PNP
4deoxyguanosine44 2411.0PNP, DGUOK
5deoxyuridine44 2410.9DGUOK, PNP
6purine nucleoside449.8PNP, DGUOK
7deoxycytidine44 2410.8PNP, DGUOK
8ricin449.8RNASE1, CD4
9dgtp44 2410.7PNP, DGUOK
10didanosine44 1110.7PNP, CD4, DGUOK
11polynucleotide449.7PNP, RNASE1
12guanosine44 11 2411.6PNP, RNASE1, DGUOK
13pyrimidine44 2410.6DGUOK, RNASE1, PNP
142-chlorodeoxyadenosine449.5PNP, DGUOK
15serine449.0XRCC5, CD4, RNASE1, RAG2
16oligonucleotide448.6RNASE1, CD4, GATA2, XRCC5, C1D

GO Terms for genes affiliated with T Lymphocyte Deficiency

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16Gene Ontology
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Cellular components related to T Lymphocyte Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1T cell receptor complexGO:0421019.8CD4, CD3G

Biological processes related to T Lymphocyte Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1purine nucleobase metabolic processGO:0061449.8PNP, DGUOK
2purine-containing compound salvageGO:0431019.5PNP, DGUOK

Products for genes affiliated with T Lymphocyte Deficiency

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Sources for T Lymphocyte Deficiency

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet