MCID: TLY001
MIFTS: 40

T Lymphocyte Deficiency malady

Immune diseases category

Summaries for T Lymphocyte Deficiency

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: T Lymphocyte Deficiency, also known as t-lymphocyte immunodeficiency, is related to thyroiditis and progressive multifocal leukoencephalopathy. An important gene associated with T Lymphocyte Deficiency is GATA2 (GATA binding protein 2), and among its related pathways are Primary immunodeficiency and Immune response Antigen presentation by MHC class II. The compounds 9-(beta-d-arabinofuranosyl)guanine and nelarabine have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related mouse phenotypes are cellular and homeostasis/metabolism.

Aliases & Classifications for T Lymphocyte Deficiency

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

t lymphocyte deficiency 8 10
t-lymphocyte immunodeficiency 8 60
t-lymphocyte deficiency 8 60
t-cell immunodeficiency 8


External Ids:

Disease Ontology8 DOID:613
SNOMED-CT56 402792003
NCIt39 C27145

Related Diseases for T Lymphocyte Deficiency

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to T Lymphocyte Deficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 37)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.3CD4
2progressive multifocal leukoencephalopathy30.2CD4
3t-cell immunodeficiency, congenital alopecia and nail dystrophy10.5
4t cell immunodeficiency primary10.3
5ectodermal dysplasia, anhidrotic, with t-cell immunodeficiency10.3
6t-cell immunodeficiency, recurrent infections, autoimmunity, and cardiac malformations10.3
7t-cell immunodeficiency with epidermodysplasia verruciformis10.3
8nezelof syndrome10.2
9immune defect due to absence of thymus10.2
10purine nucleoside phosphorylase deficiency10.2
11alopecia and t-cell immunodeficiency10.2
12vaccinia10.0
13down syndrome10.0
14graves' disease10.0
15t cell deficiency10.0
16pure red-cell aplasia10.0
17dyskeratosis congenita10.0
18autoimmune thrombocytopenic purpura10.0
19molluscum contagiosum10.0
20cartilage-hair hypoplasia10.0
21eosinophilia10.0
22purpura10.0
23charge syndrome10.0
24lymphopenia10.0PNP
25severe combined immunodeficiency10.0RAG2, PNP, CD3G
26hematologic cancer10.0DGUOK, GATA2, PNP
27arthritis10.0RAG2, CD4
28chediak-higashi syndrome10.0RAB27A, LYST
29primary immunodeficiency disease10.0PNP, CD4
30precursor t-cell acute lymphoblastic leukemia10.0PNP, GATA2, CD4
31herpes simplex10.0PNP, CD4, DGUOK
32chronic lymphocytic leukemia10.0PNP, CD4, DGUOK
33t-cell leukemia10.0CD4, RAG2, PNP
34malignant glioma10.0XRCC5, CD4, RNASE1, PNP
35melanoma10.0PNP, RAB27A, RNASE1, CD4, XRCC5
36ipex syndrome10.0CD3G, CD4, RNASE1, DGUOK, RAB27A, PNP
37leukemia10.0PNP, RNASE1, DGUOK, RAG2, XRCC5, CD4

Graphical network of the top 20 diseases related to T Lymphocyte Deficiency:



Diseases related to t lymphocyte deficiency

Clinical Features for T Lymphocyte Deficiency

About this section

Drugs & Therapeutics for T Lymphocyte Deficiency

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for T Lymphocyte Deficiency

Drug clinical trials:

Search ClinicalTrials for T Lymphocyte Deficiency

Search NIH Clinical Center for T Lymphocyte Deficiency

Search CenterWatch for T Lymphocyte Deficiency

Genetic Tests for T Lymphocyte Deficiency

About this section

Anatomical Context for T Lymphocyte Deficiency

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to T Lymphocyte Deficiency:

32
T cells, B cells, Bone, Bone marrow, Thyroid, Thymus

Animal Models for T Lymphocyte Deficiency or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to T Lymphocyte Deficiency:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.5LYST, PNP, RAB27A, RAG2, CD4, CD3G
2MP:00053767.3GATA2, CD4, RAG2, RAB27A, PNP, SRSF4
3MP:00053877.1XRCC5, CD3G, CD4, RAG2, RAB27A, PNP
4MP:00053977.0LYST, SRSF4, PNP, RAB27A, RAG2, CD4

Publications for T Lymphocyte Deficiency

About this section
Sources:
50PubMed
See all sources

Articles related to T Lymphocyte Deficiency:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
STIM1 and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjogren's syndrome. (22904194)
2012
2
Progressive multifocal leukoencephalopathy associated with mycophenolate mofetil treatment in a woman with lupus and CD4+ T-lymphocyte deficiency. (21976399)
2012
3
Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus. (22496215)
2012
4
Progressive multifocal leukoencephalopathy associated with isolated CD8+ T-lymphocyte deficiency mimicking tumefactive MS. (21786075)
2011
5
Nonhealing wound due to Rhodococcus equi in an apparently immunocompetent patient, revealing CD8+ T-lymphocyte deficiency. (20881171)
2010
6
Early effects on T lymphocyte response to iron deficiency in mice. Short communication. (18825318)
2009
7
Deficiency of forkhead box P3 and cytotoxic T-lymphocyte-associated antigen-4 gene expressions and impaired suppressor function of CD4(+)CD25(+) T cells in patients with autoimmune hepatitis. (18624718)
2008
8
Transferrin receptor in proliferation of T lymphocytes in infants with iron deficiency. (17617082)
2007
9
Complement-dependent enhancement of CD8+ T cell immunity to lymphocytic choriomeningitis virus infection in decay-accelerating factor-deficient mice. (17709533)
2007
10
Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells. (16914553)
2006
11
Immunoproteasome-deficient mice mount largely normal CD8+ T cell responses to lymphocytic choriomeningitis virus infection and DNA vaccination. (16002717)
2005
12
Normal lytic granule secretion by cytotoxic T lymphocytes deficient in BLOC-1, -2 and -3 and myosins Va, VIIa and XV. (15702992)
2005
13
Essential roles of perforin in antigen-specific cytotoxicity mediated by human CD4+ T lymphocytes: analysis using the combination of hereditary perforin-deficient effector cells and Fas-deficient target cells. (12574394)
2003
14
Successful immunosuppressive therapy with cyclosporine A for posthepatitis B-cell deficiency with activated cytoplasmic interferon--gamma-positive T-lymphocytes. (11999357)
2002
15
cDNA array analysis identifies thymic LCK as upregulated in moderate murine zinc deficiency before T-lymphocyte population changes. (11739864)
2001
16
Specific deficiency of p56lck expression in T lymphocytes from type 1 diabetic patients. (11067948)
2000
17
Persistent virus infection despite chronic cytotoxic T-lymphocyte activation in gamma interferon-deficient mice infected with lymphocytic choriomeningitis virus. (11044074)
2000
18
High-efficiency gene transfer into normal and adenosine deaminase-deficient T lymphocytes is mediated by transduction on recombinant fibronectin fragments. (9573255)
1998
19
T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates. (9662367)
1998
20
Signaling through a CD3 gamma-deficient TCR/CD3 complex in immortalized mature CD4+ and CD8+ T lymphocytes. (9743383)
1998
21
Cell-cycle arrest and apoptosis hypersusceptibility as a consequence of Lck deficiency in nontransformed T lymphocytes. (9770514)
1998
22
Phenotypical and functional characterization of Herpesvirus saimiri-immortalized human major histocompatibility complex class II-deficient T lymphocytes. (9550325)
1998
23
Successful peripheral T-lymphocyte-directed gene transfer for a patient with severe combined immune deficiency caused by adenosine deaminase deficiency. (9414266)
1998
24
Virus-specific, CD8+ major histocompatibility complex class I-restricted cytotoxic T lymphocytes in lymphocytic choriomeningitis virus-infected beta2-microglobulin-deficient mice. (9343195)
1997
25
Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice. (9215624)
1997
26
T-cell-mediated immunity to lymphocytic choriomeningitis virus in beta2-integrin (CD18)- and ICAM-1 (CD54)-deficient mice. (8971031)
1996
27
Decreased number of CD73 (ecto-5'-nucleotidase) molecules on lymphocytes from patients with primary immunoglobulin deficiencies. Correlation between number of CD73 molecules and T-lymphocyte function in vitro. (8693293)
1996
28
Molecular analysis of T lymphocyte-directed gene therapy for adenosine deaminase deficiency: long-term expression in vivo of genes introduced with a retroviral vector. (8773514)
1996
29
Enhanced susceptibility to human immunodeficiency virus infection in CD4+ T lymphocytes genetically deficient in CD43. (8554898)
1995
30
Correction of proliferative responses in purine nucleoside phosphorylase (PNP)-deficient T lymphocytes by retroviral-mediated PNP gene transfer and expression. (7876563)
1995
31
Clinical consequences and treatment of primary immunodeficiency syndromes characterized by functional T and B lymphocyte anomalies (combined immune deficiency). (8121739)
1994
32
Transfer of lymphocytic choriomeningitis disease in beta 2-microglobulin-deficient mice by CD4+ T cells. (7903551)
1993
33
TCR V alpha- and V beta-gene segment use in T-cell subcultures derived from a type-III bare lymphocyte syndrome patient deficient in MHC class-II expression. (1320968)
1992
34
A hereditary immunodeficiency characterized by CD8+ T lymphocyte deficiency and impaired lymphocyte activation. (1333922)
1992
35
Transfer of the ADA gene into human ADA-deficient T lymphocytes reconstitutes specific immune functions. (1325209)
1992
36
Human immunodeficiency virus (HIV) infection in CD4+ T lymphocytes genetically deficient in LFA-1: LFA-1 is required for HIV-mediated cell fusion but not for viral transmission. (1671082)
1991
37
Defective T-lymphocyte signal transduction and function in leukocyte adhesion deficiency. (1918265)
1991
38
Activities of purine catabolism related enzymes in zinc deficiency: relationship to T-lymphocyte dysfunction and hyperammonemia. (1906845)
1991
39
Activation of CD8+ T cells by allogeneic class II-deficient B-cell lines derived from patients with bare lymphocyte syndrome. (2142838)
1990
40
Reconstitution of T- and B-cell function after T-lymphocyte-depleted haploidentical bone marrow transplantation in severe combined immunodeficiency due to adenosine deaminase deficiency. (3304740)
1987
41
Interleukin 2 liberation and absorption capacities of rat T lymphocytes in conditions of severe adenylic nucleotide pool depletion due to adenosine deaminase deficiency. (3877709)
1985
42
Autologous mixed lymphocyte reaction in man. XI. Deficiency of autologous mixed lymphocyte reaction and abnormalities of monoclonal antibody-defined T-cell subsets in chronic mucocutaneous candidiasis. (2992070)
1985
43
The Omenn's syndrome: histological, immunohistochemical and ultrastructural evidence for a partial T cell deficiency evolving in an abnormal proliferation of T lymphocytes and S-100 +/T-6 + Langerhans-like cells. (3925627)
1985
44
Nature of T lymphocyte deficiency in atopic allergy. (315516)
1979
45
Impaired defense against vaccinia in a child with T-lymphocyte deficiency associated with inosine phosphorylase defect. (416187)
1978
46
Pyridoxine deficiency and cytotoxicity of T lymphocytes in vitro. (149594)
1978
47
T-lymphocyte deficiency in Down syndrome. (67528)
1977
48
T-Lymphocyte deficiency following adult thymectomin man. (1079964)
1975
49
The effect of T lymphocyte deficiency on tumor induction and growth. (1104194)
1975
50
Lack of suppression of certain immunoglobulin-producing lymphocytes in T-lymphocyte deficiency. (4215606)
1974

Genetic Variations for T Lymphocyte Deficiency

About this section

Expression for genes affiliated with T Lymphocyte Deficiency

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with T Lymphocyte Deficiency

Search GEO for disease gene expression data for T Lymphocyte Deficiency.

Pathways for genes affiliated with T Lymphocyte Deficiency

About this section
Sources:
29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 4Cell Signaling Technology
See all sources

Pathways related to T Lymphocyte Deficiency according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8RAG2, CD4
2
Immune response Antigen presentation by MHC class II
Hide members
9.8CD4, CD3G
39.8CD3G, CD4
4
Hide members
9.6CD4, XRCC5
59.4CD4, GATA2, XRCC5

Compounds for genes affiliated with T Lymphocyte Deficiency

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB
See all sources

Compounds related to T Lymphocyte Deficiency according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
19-(beta-d-arabinofuranosyl)guanine4410.1PNP, DGUOK
2nelarabine44 1111.1DGUOK, PNP
3deoxyadenosine44 2411.0DGUOK, PNP
4deoxyguanosine44 2411.0PNP, DGUOK
5deoxyuridine44 2410.9DGUOK, PNP
6purine nucleoside449.8PNP, DGUOK
7deoxycytidine44 2410.8PNP, DGUOK
8ricin449.8RNASE1, CD4
9dgtp44 2410.7PNP, DGUOK
10didanosine44 1110.7PNP, CD4, DGUOK
11polynucleotide449.7PNP, RNASE1
12guanosine44 11 2411.6PNP, RNASE1, DGUOK
13pyrimidine44 2410.6DGUOK, RNASE1, PNP
142-chlorodeoxyadenosine449.5PNP, DGUOK
15serine449.0XRCC5, CD4, RNASE1, RAG2
16oligonucleotide448.6RNASE1, CD4, GATA2, XRCC5, C1D

GO Terms for genes affiliated with T Lymphocyte Deficiency

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to T Lymphocyte Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1T cell receptor complexGO:0421019.8CD4, CD3G

Biological processes related to T Lymphocyte Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1purine nucleobase metabolic processGO:0061449.8PNP, DGUOK
2purine-containing compound salvageGO:0431019.5PNP, DGUOK

Products for genes affiliated with T Lymphocyte Deficiency

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for T Lymphocyte Deficiency

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet