MCID: TLY002
MIFTS: 34

T-Lymphocytopenia malady

Immune diseases category

Summaries for T-Lymphocytopenia

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32MalaCards
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MalaCards: T-Lymphocytopenia, also known as t-lymphocytopenia, idiopathic cd4-positive, is related to tuberculosis and meningitis. An important gene associated with T-Lymphocytopenia is KIR2DL3 (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3), and among its related pathways are Interleukin-3, 5 and GM-CSF signaling and PEDF Induced Signaling. The compounds cycloheximide and prednisolone have been mentioned in the context of this disorder. Related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Aliases & Classifications for T-Lymphocytopenia

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42NIH Rare Diseases, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

t-lymphocytopenia 42 60
t-lymphocytopenia, idiopathic cd4-positive 60
idiopathic cd4 positive t-lymphocytopenia 42


Related Diseases for T-Lymphocytopenia

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17GeneCards, 18GeneDecks
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Diseases related to T-Lymphocytopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 202)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis30.7LBR, CRP, ANXA5, IL7, IL4, IL2
2meningitis30.5ALB, CRP
3hodgkin's lymphoma30.4IL2, IL2RB, IL7
4pneumonia30.4IL2RB, ANXA5, CRP
5sarcoma30.2IL2
6mycosis fungoides30.2IL7, IL2RB, IL2
7sarcoidosis30.2LBR, ANXA5, IL2RB, IL2
8hepatitis30.2FAS, IL2RB, ALB
9neuropathy30.0ALB
10dermatitis30.0IL4
11malaria30.0IL2RB, ALB
12cystic fibrosis30.0ALB, ANXA5
13astrocytoma30.0CD59, ANXA5
14acquired immunodeficiency syndrome30.0IL2, ALB
15pulmonary sarcoidosis30.0IL2, IL2RB, LBR
16asthma30.0IL4, IL7, LBR
17lung cancer30.0ANXA5, IL2, ALB
18hepatitis c30.0IL2, IL4, FAS
19connective tissue disease30.0ANXA5, IL4, IL2, ALB
20arthritis30.0CRP, CD59, IL4, IL2RB, ALB
21non-hodgkin lymphoma30.0FAS, LBR, ANXA5, CD59, IL7, IL2RB
22rheumatoid arthritis29.9FAS, LBR, CRP, ANXA5, CD59, IL7
23progressive multifocal leukoencephalopathy10.4
24cryptococcosis10.4
25idiopathic cd4-positive t-lymphocytopenia10.4
26pulmonary tuberculosis10.3
27herpes zoster10.2
28kaposi's sarcoma10.2
29aspergillosis10.2
30esophagitis10.2
31retinitis10.2
32esophageal candidiasis10.0
33plasmodium malariae malaria10.0
34esophageal tuberculosis10.0
35axonal neuropathy10.0
36pure red-cell aplasia10.0
37mixed connective tissue disease10.0
38common variable immunodeficiency10.0
39bacterial esophagitis10.0
40meningoencephalitis10.0
41bronchiectasis10.0
42miliary tuberculosis10.0
43adenosine deaminase deficiency10.0
44intestinal tuberculosis10.0
45down syndrome10.0
46spinal cord astrocytoma10.0
47epidermodysplasia verruciformis10.0
48alopecia10.0
49alopecia areata10.0
50candidiasis10.0

Graphical network of the top 20 diseases related to T-Lymphocytopenia:



Diseases related to t-lymphocytopenia

Clinical Features for T-Lymphocytopenia

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Drugs & Therapeutics for T-Lymphocytopenia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for T-Lymphocytopenia

Drug clinical trials:

Search ClinicalTrials for T-Lymphocytopenia

Search NIH Clinical Center for T-Lymphocytopenia

Search CenterWatch for T-Lymphocytopenia

Genetic Tests for T-Lymphocytopenia

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Anatomical Context for T-Lymphocytopenia

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Animal Models for T-Lymphocytopenia or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to T-Lymphocytopenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.4IL2RB, FAS, CD59
2MP:00053798.2CD59, FAS, IL4, IL2RB, IL2, LBR
3MP:00053707.4ALB, FAS, IL4, IL2RB, IL2, XCL1
4MP:00053847.4NHEJ1, IL2RB, IL4, IL7, CD59, LBR
5MP:00053817.4ALB, FAS, LBR, IL4, IL2, XCL1
6MP:00053977.1CD59, NHEJ1, IL4, XCL1, IL2, FAS
7MP:00053876.5NHEJ1, IL2, IL2RB, IL4, IL7, ANXA5
8MP:00053766.5IL2, FAS, LBR, CRP, CD59, IL4

Publications for T-Lymphocytopenia

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Genetic Variations for T-Lymphocytopenia

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Expression for genes affiliated with T-Lymphocytopenia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with T-Lymphocytopenia

Search GEO for disease gene expression data for T-Lymphocytopenia.

Pathways for genes affiliated with T-Lymphocytopenia

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Sources:
53Reactome, 51QIAGEN, 29KEGG, 52R&D Systems, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to T-Lymphocytopenia according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.5IL7, IL2RB, IL2
2
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9.5XCL1, FAS
3
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9.3IL2RB, IL2, FAS
49.3CD59, IL4, IL7
5
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9.2IL4, IL2, IL2RB
69.2IL4, IL2RB, IL2
7
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9.2IL2, IL4, IL2RB
8
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8.9IL2, IL2RB, IL7, IL7, CD59
9
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8.9IL7, IL4, IL2, IL2RB
108.9IL2RB, IL4, IL7, IL2
118.9IL2, IL2RB, IL4, IL7
12
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8.8IL2, KIR2DL3, FAS, IL4
13
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8.7FAS, IL2, IL2RB, IL4
148.7FAS, IL4, IL2RB, IL2

Compounds for genes affiliated with T-Lymphocytopenia

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to T-Lymphocytopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6IL2RB
2prednisolone44 28 1112.1CRP, IL2RB
3r-il-24410.1IL2, IL2RB
4ctla4-ig449.9IL7, IL2RB, IL2
5glucose449.9CD59, LBR
6basiliximab44 1110.9IL2, IL7, IL2RB
7tdac449.7IL4, IL2
8fitc449.7ANXA5, CD59, IL2RB
9pentoxifylline44 1110.6IL4, IL2RB, LBR
10c-d4t449.6IL2, IL4, IL7
11alpha-galactosylceramide449.6IL2, IL4, IL7
12il-12449.5IL4, IL7, IL2
133-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.5ANXA5, FAS, IL7
14dexamethasone44 49 28 1112.5LBR, ANXA5, IL7, FAS
152-chlorodeoxyadenosine449.5ANXA5, IL2, FAS
16con a449.3IL2RB, IL4, LBR, IL2
17auranofin44 59 28 1112.3ALB, IL2, IL2RB
18il 10449.3IL4, IL7, IL2RB, IL2
19methylcellulose449.3IL7, ANXA5, CD59, IL4
20mycophenolic acid44 49 1111.2IL2RB, IL2, ALB
21fludarabine44 1110.2IL2, FAS, ANXA5
22polysulfone449.1ALB, CRP, IL2RB
23cyclosporin a44 28 5911.1ANXA5, CD59, IL2RB, XCL1, LBR
24mycophenolate mofetil44 49 1111.1IL2, ALB, IL2RB
25naloxone44 49 28 1112.0IL2, ALB, IL2RB
26heparin44 28 11 2411.9IL7, XCL1, FAS, LBR, ANXA5
27cisplatin44 49 59 1111.8LBR, ANXA5, IL2, IL2RB, FAS
28neopterin448.8CRP, LBR, IL2, IL2RB, IL4
29cyclophosphamide44 49 1110.8IL7, CRP, IL2, IL4, IL2RB
30genistein44 28 59 2 11 2413.8IL7, FAS, LBR, ANXA5, IL2RB, IL2
31azathioprine44 49 2 1111.8IL2, IL2RB, IL4, CRP, CD59
32methacholine44 119.7CRP, IL4, IL2RB
33aspirin44 49 28 2411.6CD59, IL2RB, FAS, CRP, IL4
34rantes448.6FAS, LBR, IL2, IL2RB, IL4, IL7
35ionomycin448.6IL2RB, FAS, LBR, IL7, IL4, IL2
36n acetylcysteine448.5CRP, IL2RB, IL4, ANXA5, FAS
37infliximab44 49 1110.3ANXA5, IL2RB, IL4, CRP, LBR, FAS
38rapamycin448.3IL2RB, IL7, ANXA5, CRP, LBR, FAS
39cholesterol44 28 11 2411.3CD59, IL2RB, IL7, CRP, LBR, ALB
40histamine44 28 2410.2IL4, IL2RB, IL2, ALB, IL7, LBR
41ivig448.2ALB, CRP, IL4, FAS, IL2RB
42thymidine44 249.2ANXA5, FAS, IL7, IL2RB, IL2, IL4
43okt3448.1IL4, IL2, IL2RB, IL7, CRP, LBR
44lactate448.0FAS, ANXA5, CD59, IL2RB, ALB, CRP
45tacrolimus44 49 1110.0ALB, IL2, IL7, XCL1, IL2RB, IL4
46vegf447.9IL2, CRP, IL2RB, IL4, IL7, ANXA5
47lipid447.8IL7, IL2RB, CD59, CRP, LBR, ALB
48tyrosine447.6IL2, IL7, CD59, IL2RB, FAS, ANXA5
49cysteine447.4FAS, IL7, IL4, XCL1, ALB, LBR
50calcium44 49 11 2410.2IL2RB, XCL1, IL7, CD59, ANXA5, CRP

GO Terms for genes affiliated with T-Lymphocytopenia

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16Gene Ontology
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Cellular components related to T-Lymphocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.4IL2RB, IL4, ANXA5, FAS
2extracellular regionGO:0055767.2FAS, CRP, CD59, IL7, IL2, XCL1
3extracellular spaceGO:0056156.9IL2, XCL1, ALB, IL7, CD59, CRP

Biological processes related to T-Lymphocytopenia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:0483049.6IL2, IL4
2positive regulation of T cell differentiationGO:0455829.6IL4, IL7
3positive regulation of activated T cell proliferationGO:0421049.5IL2, IL4
4positive regulation of B cell proliferationGO:0308909.4IL7, IL4, IL2
5positive regulation of interleukin-10 productionGO:0327339.2IL4, XCL1
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.2IL2, IL4
7immune responseGO:0069558.8XCL1, KIR2DL3, IL2, IL4
8negative regulation of apoptotic processGO:0430667.1ALB, IL2, FAS, ANXA5, IL2RB, IL4

Molecular functions related to T-Lymphocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.2IL2, IL4, IL7
2growth factor activityGO:0080838.9IL2, IL4, IL7

Products for genes affiliated with T-Lymphocytopenia

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Sources for T-Lymphocytopenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet