MCID: TKY001
MIFTS: 57

Takayasu's Arteritis malady

Rare diseases, Cardiovascular diseases, Nephrological diseases, Bone diseases categories

Aliases & Classifications for Takayasu's Arteritis

About this section
Sources:
10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 65UMLS, 36MeSH, 59SNOMED-CT, 42NCIt, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet, 27ICD10
See all sources

Aliases & Descriptions for Takayasu's Arteritis:

Name: Takayasu's Arteritis 10 12
Takayasu Arteritis 10 45 51 65
Aortic Arch Syndromes 65 36
Aortic Arch Syndrome 10 45
Idiopathic Aortitis 10 65
Takayasu's Disease Pulseless 10
Young Female Arteritis 45
 
Aortic Arch Arteritis 10
Aortic Arches Defect 45
Takayasu's Disease 10
Pulseless Disease 45
Takayasu Disease 45
Ta 45


Classifications:



Characteristics (Orphanet epidemiological data):

51
takayasu arteritis:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult


External Ids:

Disease Ontology10 DOID:2508
MeSH36 D001015
NCIt42 C34391
Orphanet51 3287
ICD10 via Orphanet28 M31.4
MESH via Orphanet37 D013625
UMLS via Orphanet66 C0039263
ICD1027 M31.4

Summaries for Takayasu's Arteritis

About this section
NIH Rare Diseases:45 Takayasu arteritis is a condition that causes inflammation of the main blood vessel that carries blood from the heart to the rest of the body (aorta) and its associated branched blood vessels. as a result of the inflammation, the blood vessel walls become thick and make it difficult for blood to flow. over time, impaired blood flow causes damage to the heart and various other organs of the body.  although the cause remains unknown, takayasu arteritis appears to be an autoimmune condition, in which cells that fight infection and disease are wrongly targeted against the body's own tissues. last updated: 11/3/2013

MalaCards based summary: Takayasu's Arteritis, also known as takayasu arteritis, is related to ischemic optic neuropathy and relapsing polychondritis, and has symptoms including hyperhidrosis, weight loss and aneurysm. An important gene associated with Takayasu's Arteritis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways are Cytokines and Inflammatory Response and Pertussis. The drug alprostadil has been mentioned in the context of this disorder. Affiliated tissues include heart, skin and t cells, and related mouse phenotypes are mortality/aging and cardiovascular system.

Disease Ontology:10 A syndrome that involves inflammation of the aorta that carries blood from the heart to the rest of the body.

Related Diseases for Takayasu's Arteritis

About this section

Diseases related to Takayasu's Arteritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 299)
idRelated DiseaseScoreTop Affiliating Genes
1ischemic optic neuropathy30.7CRP, F3, IL6, TNF
2relapsing polychondritis30.2F3, SERPINC1
3wegener granulomatosis30.1CRP, HLA-DPB1, IL6, SELE, TNF, VWF
4systemic lupus erythematosus29.6CD40LG, CRP, F3, HLA-DPB1, IL6, THBD
5myocardial infarction29.3CRP, F3, IL6, MMP3, MMP9, PON1
6renovascular hypertension10.5
7ulcerative colitis10.4
8cerebritis10.4
9aortic disease10.4
10colitis10.4
11cerebral aneurysms10.4
12atypical coarctation of aorta10.4
13skin conditions10.4
14skin disease10.4
15subclavian steal syndrome10.4
16vascular skin disease10.4
17polyarteritis nodosa10.4
18cryoglobulinemia10.4HLA-B, IL6
19rheumatoid vasculitis10.4MMP3, MMP9
20cold urticaria10.4CRP, IL6
21anti-hla hyperimmunization10.3HLA-B, IL6, TNF
22thymus basaloid carcinoma10.3HLA-B, IL6, TNF
23cicatricial lagophthalmos10.3CRP, IL6, TNF
24congenital heart disease10.3HLA-B, IL6, TNF
25endocervicitis10.3CRP, IL6, TNF
26drug dependence10.3CRP, MMP9, TNF
27actinic lichen planus10.3MMP9, TNF
28infiltrating renal pelvis transitional cell carcinoma10.3CRP, IL6, TNF
29genital herpes10.3HLA-B, IL6, TNF
30bardet-biedl syndrome 810.3CRP, IL6, TNF
31kartagener syndrome10.3IL6, MMP3, TNF
32cerebellar astrocytoma10.3CD40LG, CRP, IL6
33intestinal impaction10.3CD40LG, CRP, IL6
34mesenteric vascular occlusion10.3CRP, IL6, TNF
35pericardium cancer10.3CRP, IL6, TNF
36pyloric stenosis10.3CRP, IL6, TNF
37balanitis xerotica obliterans10.3HLA-B, IL6, TNF
38anterior cerebral artery infarction10.3CD40LG, CRP, IL6
39common variable immunodeficiency10.3
40dilated cardiomyopathy10.3
41glomerulonephritis10.3
42membranoproliferative glomerulonephritis10.3
43carotid artery dissection10.3
44carotid artery occlusion10.3
45malignant hypertension10.3
46neuropathy10.3
47purpura10.3
48thyroiditis10.3
49coronary artery aneurysm10.3
50fibromuscular dysplasia10.3

Graphical network of the top 20 diseases related to Takayasu's Arteritis:



Diseases related to takayasu's arteritis

Symptoms for Takayasu's Arteritis

About this section

Symptoms:

 51 (show all 41)
  • hyperhidrosis/increased sweating
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • cardiac valvulopathy
  • acute arterial hypertension/hypertensive crisis
  • arterial stenosis/occlusion
  • arterial pulse abolition
  • arterial aneurism (excluding aorta)
  • vascularitis/vasculitides/arteritis
  • acute ischemic syndrome
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • asthenia/fatigue/weakness
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • visual loss/blindness/amblyopia
  • chronic skin infection/ulcerations/ulcers/cancrum
  • thoracic/chest pain
  • respiratory rhythm disorder
  • pulmonary hypertension
  • aortic valve atresia/stenosis/narrowing/supra-aortic/supra-valvular stenosis
  • cardiomyopathy/hypertrophic/dilated
  • aortic root dilatation/dilation/aneurysm
  • angor pectoris/myocardial infarction
  • chronic arterial hypertension
  • gangrena/necrosis
  • facial pain/cephalalgia/migraine
  • seizures/epilepsy/absences/spasms/status epilepticus
  • anorexia
  • muscle weakness/flaccidity
  • myalgia/muscular pain
  • arthritis/synovitis/synovial proliferation
  • anaemia
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • retinopathy
  • transient amaurosis/acute visual trouble
  • hemoptysis
  • endocardium anomalies/fibroelastosis/endocarditis
  • mesenteric/intestinal infarction
  • transient cerebral ischemia/stroke
  • obnubilation/coma/lethargia/desorientation
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
  • articular/joint pain/arthralgia

HPO human phenotypes related to Takayasu's Arteritis:

(show all 40)
id Description Frequency HPO Source Accession
1 hyperhidrosis hallmark (90%) HP:0000975
2 weight loss hallmark (90%) HP:0001824
3 aneurysm hallmark (90%) HP:0002617
4 vasculitis hallmark (90%) HP:0002633
5 abnormality of temperature regulation hallmark (90%) HP:0004370
6 hypertensive crisis hallmark (90%) HP:0100735
7 abnormality of the aorta hallmark (90%) HP:0001679
8 visual impairment typical (50%) HP:0000505
9 seizures typical (50%) HP:0001250
10 muscle weakness typical (50%) HP:0001324
11 arthritis typical (50%) HP:0001369
12 hypertrophic cardiomyopathy typical (50%) HP:0001639
13 abnormality of the aortic valve typical (50%) HP:0001646
14 coronary artery disease typical (50%) HP:0001677
15 anemia typical (50%) HP:0001903
16 anorexia typical (50%) HP:0002039
17 migraine typical (50%) HP:0002076
18 pulmonary hypertension typical (50%) HP:0002092
19 abnormal pattern of respiration typical (50%) HP:0002793
20 myalgia typical (50%) HP:0003326
21 dilatation of the ascending aorta typical (50%) HP:0005111
22 inflammatory abnormality of the eye typical (50%) HP:0100533
23 chest pain typical (50%) HP:0100749
24 gangrene typical (50%) HP:0100758
25 skin ulcer typical (50%) HP:0200042
26 respiratory insufficiency typical (50%) HP:0002093
27 apnea typical (50%) HP:0002104
28 retinopathy occasional (7.5%) HP:0000488
29 hemoptysis occasional (7.5%) HP:0002105
30 neurological speech impairment occasional (7.5%) HP:0002167
31 cerebral ischemia occasional (7.5%) HP:0002637
32 arthralgia occasional (7.5%) HP:0002829
33 abnormality of the endocardium occasional (7.5%) HP:0004306
34 reduced consciousness/confusion occasional (7.5%) HP:0004372
35 gastrointestinal infarctions occasional (7.5%) HP:0005244
36 amaurosis fugax occasional (7.5%) HP:0100576
37 asthma occasional (7.5%) HP:0002099
38 recurrent respiratory infections occasional (7.5%) HP:0002205
39 feeding difficulties in infancy occasional (7.5%) HP:0008872
40 arteritis HP:0012089

Drugs & Therapeutics for Takayasu's Arteritis

About this section

Drugs for Takayasu's Arteritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Omega 3 Fatty AcidNutraceuticalPhase 4890
2
PrednisoneapprovedPhase 2120853-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
Juvason
 
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Perrigo Prednisone
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rayos
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
3
AbataceptapprovedPhase 2130332348-12-610237
Synonyms:
CTLA4-Ig
CTLA4-IgG4m
 
CTLA4Ig
CTLA4IgG4m
Orencia
4
AldesleukinapprovedPhase 237285898-30-2
Synonyms:
IL-2
Interleukin-2 precursor
 
Proleukin
T-cell growth factor
TCGF
5
InfliximabapprovedPhase 2327170277-31-3
Synonyms:
Ig gamma-1 chain C region
 
Inflectra
Remicade
Remsima
6
Epoetin alfaapprovedPhase 1, Phase 2612113427-24-0
Synonyms:
Epogen
 
Erythropoietin precursor
Procrit
7Interleukin-2Phase 2472
8
Methylprednisoloneapproved103383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
A-methapred
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Depo-medrol
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Solu-medrol
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
9
Prednisoloneapproved103350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
Flo-pred
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
MLS001304083
 
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
Millipred
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Omnipred
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
10
Cyclophosphamideapproved, investigational252550-18-0, 6055-19-22907
Synonyms:
(+-)-Cyclophosphamide
(-)-Cyclophosphamide
(RS)-Cyclophosphamide
1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine
1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin
2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide
4-Hydroxy-cyclophosphan-mamophosphatide
50-18-0
60007-95-6
6055-19-2 (monohydrate)
75526-90-8
AC1L1EQQ
AI3-26198
ASTA
ASTA B518
Asta B 518
B 518
B-518
BRN 0011744
BSPBio_002099
Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester
C 0768
C07888
C7H15Cl2N2O2P
CB 4564
CB-4564
CCRIS 188
CHEBI:4027
CHEMBL32520
CHEMBL88
CID2907
CP
CPA
CTX
CY
Ciclofosfamida
Ciclofosfamida [INN-Spanish]
Ciclofosfamide
Ciclophosphamide
Ciclophosphamide [INN]
Clafen
Claphene
Cycloblastin
Cyclophosphamid
Cyclophosphamide
Cyclophosphamide (INN)
Cyclophosphamide (TN)
Cyclophosphamide (anhydrous form)
Cyclophosphamide (anhydrous)
Cyclophosphamide Monohydrate
Cyclophosphamide Sterile
Cyclophosphamide anhydrous
Cyclophosphamide, (+-)-Isomer
Cyclophosphamides
Cyclophosphamidum
Cyclophosphamidum [INN-Latin]
Cyclophosphan
Cyclophosphane
Cyclophosphanum
Cyclophosphoramide
Cyclostin
Cyklofosfamid
Cyklofosfamid [Czech]
Cytophosphan
Cytophosphane
Cytoxan
Cytoxan (TN)
Cytoxan Lyoph
D,L-Cyclophosphamide
D07760
DB00531
 
DivK1c_000246
EINECS 200-015-4
EU-0100238
Endoxan
Endoxan R
Endoxan-Asta
Endoxana
Endoxanal
Endoxane
Enduxan
Genoxal
HMS2090A12
HSDB 3047
Hexadrin
IDI1_000246
KBio1_000246
KBio2_001338
KBio2_003906
KBio2_006474
KBio3_001319
KBioGR_000888
KBioSS_001338
LS-1302
LS-99787
Ledoxina
Lopac-C-0768
Lopac0_000238
Lyophilized Cytoxan
Mitoxan
MolPort-001-783-420
N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
NCGC00015209-01
NCGC00015209-03
NCGC00015209-06
NCGC00091741-02
NCGC00091741-03
NCI-C04900
NCI60_002097
NINDS_000246
NSC 26271
NSC-26271
NSC26271
NSC273033
NSC273034
Neosar
Occupation, cyclophosphamide exposure
Procytox
RCRA waste no. U058
Rcra Waste Number U058
Rcra waste number U058
Revimmune
S1217_Selleck
SK 20501
SPBio_001071
STK177249
STOCK2S-91217
Semdoxan
Sendoxan
Senduxan
Spectrum2_001146
Spectrum3_000370
Spectrum4_000304
Spectrum5_000795
Spectrum_000858
UNII-6UXW23996M
WLN: T6MPOTJ BO BN2G2G
Zyklophosphamid
Zyklophosphamid [German]
bis(2-Chloroethyl)phosphami de cyclic propanolamide
bis(2-Chloroethyl)phosphamide cyclic propanolamide ester
cyclophosphamide
11Prednisolone acetate1033
12Prednisolone hemisuccinate1033
13Prednisolone phosphate1033
14Cyclosporins849
15Methylprednisolone Hemisuccinate1033
16lenograstim1108
17Antilymphocyte Serum376
18Methylprednisolone acetate1033
19CalamusNutraceutical312
20Kavanutraceutical1239000-38-85281052

Interventional clinical trials:

(show all 26)
idNameStatusNCT IDPhase
1Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein LevelsTerminatedNCT00578578Phase 4
2Efficacy and Tolerance of Tocilizumab In Takayasu ArteritisNot yet recruitingNCT02101333Phase 3
3Abatacept for Treating Adults With Giant Cell Arteritis and Takayasu's ArteritisCompletedNCT00556439Phase 2
4Clinical Study of Anti-tumor Necrosis Factor Therapy in Patients With Takayasu ArteritisRecruitingNCT02457585Phase 2
5Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory DiseasesRecruitingNCT01988506Phase 2
6Erythropoetin Neuroprotection for Neonatal Cardiac SurgeryActive, not recruitingNCT00513240Phase 1, Phase 2
7Impact and Utility of PET Versus Clinical Score for the Assessment of Inflammatory Activity in Takayasu ArteritisCompletedNCT01532167
8Carotid Artery Neovascularization in Takayasu's and Giant Cell ArteritisCompletedNCT01795456
9Educational Needs of Patients With Systemic VasculitisCompletedNCT02190929
10Reproductive Health in Men and Women With VasculitisCompletedNCT02176070
11Vasculitis Illness Perception (VIP) StudyCompletedNCT02190916
12Impact of Vasculitis on Employment and IncomeCompletedNCT02476292
13Magnetic Resonance Angiography vs Ultrasonography in Systemic Large vEssel vasculitiSCompletedNCT02042092
14Cerebral Perfusion During Neonatal Cardiac SurgeryCompletedNCT01032876
15Determining Disease Activity Biomarkers in Individuals With Takayasu's ArteritisRecruitingNCT00315471
16Use of MRI and PET for Assessing Disease Activity in Takayasu's ArteritisRecruitingNCT00744952
17Exercise in Sjogren, Myositis and Takayasu's ArteritisRecruitingNCT01501019
18American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic VasculitisRecruitingNCT01066208
19Pediatric Vasculitis InitiativeRecruitingNCT02006134
20Vasculitis Pregnancy RegistryRecruitingNCT02593565
21One-Time DNA Study for VasculitisRecruitingNCT01241305
22Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune DiseasesActive, not recruitingNCT00006055
23Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence StudyActive, not recruitingNCT01663129
24Evaluation of Panel Reactive Antibody in Children Following Stage I Palliation for Hypoplastic Left Heart SyndromeActive, not recruitingNCT01135485
25VCRC Patient Contact Registry Patient-Reported Data Validation StudyEnrolling by invitationNCT02190942
26Aortic Arch ReconstructionTerminatedNCT00277940

Search NIH Clinical Center for Takayasu's Arteritis

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: Aortic Arch Syndromes

Genetic Tests for Takayasu's Arteritis

About this section

Anatomical Context for Takayasu's Arteritis

About this section

MalaCards organs/tissues related to Takayasu's Arteritis:

33
Heart, Skin, T cells, Bone, Lung, Eye, Endothelial

Animal Models for Takayasu's Arteritis or affiliated genes

About this section

MGI Mouse Phenotypes related to Takayasu's Arteritis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107686.8CD40LG, F3, HLA-B, IL12B, IL6, MMP9
2MP:00053856.6CD40LG, CRP, F3, IL6, MMP9, PON1
3MP:00053975.9CD40LG, F3, HLA-B, IL12B, IL6, MMP3
4MP:00053765.4CD40LG, CRP, F3, IL12B, IL6, MMP3
5MP:00053874.8CD40LG, CRP, F3, HLA-B, IL12B, IL6

Publications for Takayasu's Arteritis

About this section

Articles related to Takayasu's Arteritis:

(show top 50)    (show all 566)
idTitleAuthorsYear
1
Gangrene in Takayasu's arteritis: a report of two cases and review of literature. (26563339)
2015
2
Digital Gangrene an Unusual Presentation of Takayasu's Arteritis. (25789252)
2015
3
Late diagnosis of Takayasu's arteritis with repeated attacks of heart failure and uncontrolled hypertension due to abdominal aortic thrombosis: Case report and review of the literature. (26286888)
2015
4
Angiographic profile and endovascular interventions in Takayasu's arteritis. (25589694)
2015
5
Case images: Takayasu's arteritis with left main stem stenosis of single coronary artery. (24643159)
2014
6
Takayasu's Arteritis and Crohn's Disease in a Young Hispanic Female. (25152825)
2014
7
A Case of Membranous Glomerulonephropathy Associated with Takayasu's Arteritis. (24847348)
2014
8
Takayasu's arteritis and an elevated antistreptolysin O titre - a potentially expensive diagnostic conundrum. (25057401)
2014
9
Aortic regurgitation in Takayasu's arteritis. (25288778)
2014
10
Impaired endothelial function in patients with Takayasu's arteritis. (24640521)
2014
11
Development of a colour Doppler ultrasound scoring system in patients of Takayasu's arteritis and its correlation with clinical activity score (ITAS 2010). (24014648)
2013
12
Intra-muscular arteries are also affected in Takayasu's arteritis. (23011087)
2013
13
MMP-9 and IL-6 are potential biomarkers for disease activity in Takayasu's arteritis. (22330005)
2012
14
Self-reactivity against stress-induced cell molecules: the missing link between Takayasu's arteritis and tuberculosis? (22285197)
2012
15
Proteus Takayasu's arteritis with unusual intracranial granulomatosis as initial manifestation. (20354858)
2012
16
Potential biomarkers for disease activity in Takayasu's arteritis. (22608269)
2012
17
Takayasu's arteritis in children and adolescents: report of three cases. (21953004)
2011
18
Pathogenesis of Takayasu's arteritis: a 2011 update. (21855656)
2011
19
Mycophenolate mofetil in Takayasu's arteritis. (20054700)
2010
20
Stroke as a manifestation of Takayasu's arteritis likely due to distal carotid stump embolism. (20371961)
2010
21
A case of unusual presentation of Takayasu's arteritis. (20195040)
2010
22
Takayasu's arteritis in a patient with Crohn's disease: an unexpected association during infliximab therapy. (20075586)
2010
23
Medical image. Aortic aneurysm in a girl with Takayasu's arteritis. (21326409)
2010
24
Ulcerative colitis associated with Takayasu's arteritis in a child. (19432836)
2009
25
Takayasu's arteritis mimicking aortic intramural hematoma in a female patient with chest pain. (18935716)
2008
26
Aortic aneurysm in Takayasu's arteritis. (17985414)
2007
27
Bilateral ocular ischemic syndrome as an initial manifestation of Takayasu's arteritis associated with carotid steal syndrome. (16944156)
2007
28
Takayasu's arteritis: an Indian perspective. (17383909)
2007
29
Interleukin (IL)-12, IL-2, and IL-6 gene polymorphisms in Takayasu's arteritis from Turkey. (17002904)
2006
30
Post-interventional immunosuppressive treatment and vascular restenosis in Takayasu's arteritis. (16352637)
2006
31
Unprotected left main stent placement in a patient with Takayasu's arteritis: an unusual solution for an unusual disease. (16878640)
2006
32
Takayasu's arteritis with aortic aneurysm associated with Sweet's syndrome in childhood. (15608327)
2005
33
Takayasu's arteritis and ulcerative colitis in a young non-Asian woman: a rare association. (16363285)
2005
34
Evaluation of cerebral hypoperfusion by nuclear medicine imaging in a patient with Takayasu's arteritis. (16228810)
2005
35
Refractory Takayasu's arteritis successfully treated with the human, monoclonal anti-tumor necrosis factor antibody adalimumab. (16158044)
2005
36
Intravascular ultrasound and fractional flow reserve of equivocal left main stenosis in patients with Takayasu's arteritis: impact on surgical decision-making. (15937934)
2005
37
Interleukin-8 in Takayasu's arteritis: plasma levels and relationship with disease activity. (15675131)
2004
38
Ascending aorta-abdominal aorta bypass for Takayasu's arteritis. (14681103)
2003
39
Horner's syndrome as an initial manifestation of Takayasu's arteritis. (12810438)
2003
40
Takayasu's arteritis with multiple fistulas from three coronary arteries to lung paranchima. (12714218)
2003
41
A 16-year survey of Takayasu's arteritis in a tertiary Belgian center. (15153827)
2003
42
Aortic aneurysm and aortic regurgitation following aortic valve replacement due to Takayasu's arteritis. (11855100)
2002
43
Takayasu's arteritis presenting as ischemic stroke--case report. (12481637)
2002
44
Pulmonary Takayasu's arteritis masquerading as acute pulmonary embolism. (17039181)
2001
45
Takayasu's arteritis presenting with bilateral parenchymal consolidations and severe respiratory failure. (11786722)
2001
46
Complement and cell mediated cytotoxicity by antiendothelial cell antibodies in Takayasu's arteritis. (11327255)
2001
47
Takayasu's arteritis and tuberculosis: a case report. (11147763)
2000
48
Neurosurgical and neuroendovascular management of Takayasu's arteritis. (10764257)
2000
49
Takayasu's arteritis with transient clubbed finger. (10544853)
1999
50
Primary aortoduodenal fistula treated successfully with surgery in a patient with Takayasu's arteritis. (10688426)
1999

Variations for Takayasu's Arteritis

About this section

Expression for genes affiliated with Takayasu's Arteritis

About this section
Search GEO for disease gene expression data for Takayasu's Arteritis.

Pathways for genes affiliated with Takayasu's Arteritis

About this section

Pathways related to Takayasu's Arteritis according to GeneCards Suite gene sharing:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL12B, IL6, TNF
29.8IL12B, IL6, TNF
39.8IL12B, IL6, TNF
4
Show member pathways
9.8IL12B, IL6, TNF
59.7IL6, TNF, VCAM1
69.6IL6, MMP9, TNF
79.6IL6, MMP9, THBD
89.5HLA-DPB1, IL12B, IL6, TNF
9
Show member pathways
9.5CD40LG, HLA-DPB1, IL12B, TNF
10
Show member pathways
9.5CD40LG, TNF, TNFSF8
11
Show member pathways
9.4HLA-A, HLA-B, IL12B, IL6, TNF
129.4IL12B, IL6, MMP9, TNF
139.3CD40LG, HLA-A, HLA-B, MICA, VCAM1
149.2IL12B, IL6, SELE, TNF, VCAM1
159.2CD40LG, IL6, SELE, TNF, VCAM1
16
Show member pathways
9.1HLA-A, HLA-B, HLA-DPB1, IL12B, IL6, TNF
179.0HLA-A, HLA-B, HLA-DPB1, IL6, TNF, VCAM1
189.0MMP3, MMP9, SELE
19
TNF Signaling (sino)
Show member pathways
8.9MMP3, MMP9, SELE
208.9CD40LG, HLA-A, HLA-B, HLA-DPB1, SELE, VCAM1
218.9HLA-DPB1, IL6, MMP3, TNF
22
Show member pathways
8.8F3, SERPINC1, THBD, VWF
23
Show member pathways
8.8F3, SERPINC1, THBD, VWF
24
Show member pathways
8.7CD40LG, HLA-A, HLA-B, HLA-DPB1, IL12B, IL6
258.2IL6, MMP3, MMP9, SELE, TNF, VCAM1
26
Show member pathways
8.0F3, IL6, SELE, SERPINC1, THBD, VCAM1
27
Show member pathways
7.9F3, MMP3, MMP9, SERPINC1, THBD

GO Terms for genes affiliated with Takayasu's Arteritis

About this section

Cellular components related to Takayasu's Arteritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:004261210.8HLA-A, HLA-B
2integral component of lumenal side of endoplasmic reticulum membraneGO:007155610.4HLA-A, HLA-B, HLA-DPB1
3ER to Golgi transport vesicle membraneGO:001250710.4HLA-A, HLA-B, HLA-DPB1
4external side of plasma membraneGO:00098979.6CD40LG, IL6, TNF, VCAM1, VWF
5extracellular matrixGO:00310128.3F3, MMP3, MMP9, VWF
6cell surfaceGO:00099868.0F3, HLA-A, HLA-B, HLA-DPB1, MICA, THBD
7extracellular regionGO:00055767.1CRP, IL6, MMP3, MMP9, PON1, SERPINC1
8extracellular spaceGO:00056155.1CD40LG, CRP, F3, IL12B, IL6, MICA

Biological processes related to Takayasu's Arteritis according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:000248010.8HLA-A, HLA-B
2antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentGO:000248610.8HLA-A, HLA-B
3protection from natural killer cell mediated cytotoxicityGO:004227010.7HLA-A, HLA-B
4epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.7IL6, TNF
5positive regulation of T cell mediated cytotoxicityGO:000191610.6HLA-A, HLA-B, IL12B
6regulation of immunoglobulin secretionGO:005102310.5CD40LG, TNF
7negative regulation of lipid storageGO:001088810.5CRP, IL6, TNF
8leukocyte tethering or rollingGO:005090110.2SELE, TNF, VCAM1
9positive regulation of interferon-gamma productionGO:003272910.1HLA-A, HLA-DPB1, IL12B, TNF
10leukocyte cell-cell adhesionGO:000715910.1CD40LG, SELE, VCAM1
11antigen processing and presentationGO:001988210.1HLA-A, HLA-B, HLA-DPB1, MICA
12interferon-gamma-mediated signaling pathwayGO:006033310.1HLA-A, HLA-B, HLA-DPB1, VCAM1
13positive regulation of protein kinase B signalingGO:00518979.9F3, IL6, TNF
14response to woundingGO:00096119.8F3, IL6, VWF
15positive regulation of T cell proliferationGO:00421029.8HLA-DPB1, IL12B, IL6, VCAM1
16leukocyte migrationGO:00509009.7MMP9, SELE, THBD, TNF
17inflammatory responseGO:00069549.7CD40LG, CRP, IL6, SELE, TNF
18regulation of immune responseGO:00507769.5CD40LG, HLA-A, HLA-B, MICA, VCAM1
19response to lipopolysaccharideGO:00324969.5F3, IL6, SELE, THBD
20defense response to Gram-positive bacteriumGO:00508309.4CRP, HLA-A, IL6, TNF, TNFSF8
21cytokine-mediated signaling pathwayGO:00192218.7F3, HLA-A, HLA-B, HLA-DPB1, IL12B, IL6
22immune responseGO:00069558.7CD40LG, HLA-A, HLA-B, HLA-DPB1, IL6, MICA
23extracellular matrix organizationGO:00301988.3MMP3, MMP9, TNF, VCAM1, VWF
24blood coagulationGO:00075968.2F3, SELE, SERPINC1, THBD, VWF

Molecular functions related to Takayasu's Arteritis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1TAP bindingGO:004697710.8HLA-A, HLA-B
2beta-2-microglobulin bindingGO:003088110.7HLA-A, MICA
3peptide antigen bindingGO:004260510.3HLA-A, HLA-B, HLA-DPB1
4tumor necrosis factor receptor bindingGO:000516410.1CD40LG, TNF, TNFSF8
5cytokine activityGO:00051259.6CD40LG, IL12B, IL6, TNF, TNFSF8
6protease bindingGO:00020209.4F3, SERPINC1, TNF, VWF
7protein bindingGO:00055154.2CD40LG, CRP, F3, HLA-A, HLA-B, HLA-DPB1

Sources for Takayasu's Arteritis

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet