MCID: TKY001
MIFTS: 56

Takayasu's Arteritis malady

Categories: Rare diseases, Cardiovascular diseases, Nephrological diseases, Bone diseases

Aliases & Classifications for Takayasu's Arteritis

About this section
Sources:
10Disease Ontology, 12DISEASES, 45NIH Rare Diseases, 65UMLS, 51Orphanet, 36MeSH, 27ICD10, 29ICD9CM, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Takayasu's Arteritis:

Name: Takayasu's Arteritis 10 12
Takayasu Arteritis 10 45 51 36 65
Aortic Arch Syndromes 36 65
Aortic Arch Syndrome 10 45
Idiopathic Aortitis 10 65
Young Female Arteritis 45
 
Aortic Arch Arteritis 10
Aortic Arches Defect 45
Takayasu's Disease 10
Pulseless Disease 45
Takayasu Disease 45
Ta 45

Characteristics:

Orphanet epidemiological data:

51
takayasu arteritis:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult

Classifications:



External Ids:

Disease Ontology10 DOID:2508
ICD1027 M31.4
ICD9CM29 446.7
Orphanet51 3287
ICD10 via Orphanet28 M31.4
MESH via Orphanet37 D013625
UMLS via Orphanet66 C0039263
UMLS65 C0003490, C0039263, C3146222

Summaries for Takayasu's Arteritis

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NIH Rare Diseases:45 Takayasu arteritis is a condition that causes inflammation of the main blood vessel that carries blood from the heart to the rest of the body (aorta) and its associated branched blood vessels. as a result of the inflammation, the blood vessel walls become thick and make it difficult for blood to flow. over time, impaired blood flow causes damage to the heart and various other organs of the body.  although the cause remains unknown, takayasu arteritis appears to be an autoimmune condition, in which cells that fight infection and disease are wrongly targeted against the body's own tissues. last updated: 11/3/2013

MalaCards based summary: Takayasu's Arteritis, also known as takayasu arteritis, is related to cervical aortic arch and isotretinoin embryopathy like syndrome, and has symptoms including hypertensive crisis, abnormality of temperature regulation and vasculitis. An important gene associated with Takayasu's Arteritis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways are Legionellosis and Pertussis. The drug alprostadil has been mentioned in the context of this disorder. Affiliated tissues include heart, skin and bone, and related mouse phenotypes are respiratory system and cardiovascular system.

Disease Ontology:10 A syndrome that involves inflammation of the aorta that carries blood from the heart to the rest of the body.

Related Diseases for Takayasu's Arteritis

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Diseases related to Takayasu's Arteritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 211)
idRelated DiseaseScoreTop Affiliating Genes
1cervical aortic arch11.6
2isotretinoin embryopathy like syndrome11.5
3isotretinoin-like syndrome11.5
4bronchiolitis10.6HLA-B, IL6
5periventricular leukomalacia10.5HLA-A, HLA-B
6postinfectious encephalomyelitis10.5HLA-A, HLA-B
7cold urticaria10.5CRP, IL6
8microsomia hemifacial radial defects10.5HLA-B, TNF
9leri pleonosteosis10.5MMP2, MMP9
10cholera10.5HLA-B, IL6, TNF
11tracheal stenosis10.5HLA-B, IL6, TNF
12plantar nerve lesion10.5IL6, TNF
13intermediate dend syndrome10.5IL6, TNF
14talo-patello-scaphoid osteolysis10.5MMP2, MMP9
15conventional malignant hemangiopericytoma10.5HLA-B, IL6, TNF
16conjunctival disease10.5IL6, MMP3, MMP9
17lujo hemorrhagic fever10.5CRP, IL6, TNF
18anti-hla hyperimmunization10.5HLA-B, PTPN22, TNF
19methylmalonic acidemia10.5HLA-B, IL6, TNF
20iridocyclitis10.5HLA-A, HLA-B
21ureteral disease10.5CRP, IL6, TNF
22acneiform dermatitis10.5HLA-A, HLA-B, TNF
23dentin caries10.5CRP, IL6, TNF
24human herpesvirus 810.5HLA-A, HLA-B, IL6
25duodenal somatostatinoma10.5CRP, MMP9, TNF
26hydromyelia10.5HLA-A, HLA-B
27granulomatous orchitis10.4IL6, MMP9, TNF
28bronchopulmonary dysplasia10.4IL6, MMP9, TNF
29bardet-biedl syndrome 810.4CRP, IL6, TNF
30root resorption10.4HLA-A, HLA-B, IL6
31lymphocytic choriomeningitis10.4HLA-A, HLA-B, TNF
32erdheim-chester disease10.4CD40LG, TNF
33cytoplasmic body myopathy10.4HLA-A, HLA-B, TNF
34crohn's disease10.4IL6, TNF
35cryptosporidiosis10.4HLA-A, HLA-B, TNF
36entropion10.4MMP2, MMP3, MMP9
37motion sickness10.4CRP, IL6, TNF
38conjunctivochalasis10.4CRP, IL6, PON1
39secretory diarrhea10.4HLA-A, IL6, TNF
40inflammatory spondylopathy10.4HLA-A, HLA-B, TNF
41flat retinoschisis10.4MMP2, MMP3, MMP9
42periampullary adenoma10.4CRP, IL6, TNF
43meningitis10.4CRP, MMP9, TNF
44ovarian endometrioid cystadenoma10.4IL6, PTPN22, TNF
45liver leiomyosarcoma10.4CRP, IL6, TNF
46oral mucosa leukoplakia10.4CRP, IL6, MMP2
47obstructive sleep apnea10.4CRP, IL6, TNF
48demyelinating disease10.4HLA-A, HLA-B, MMP9
49chronic cystitis10.4CRP, IL6, TNF
50refractory plasma cell neoplasm10.4CD40LG, IL6, TNF

Graphical network of the top 20 diseases related to Takayasu's Arteritis:



Diseases related to takayasu's arteritis

Symptoms for Takayasu's Arteritis

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Symptoms:

 51 (show all 41)
  • hyperhidrosis/increased sweating
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • cardiac valvulopathy
  • acute arterial hypertension/hypertensive crisis
  • arterial stenosis/occlusion
  • arterial pulse abolition
  • arterial aneurism (excluding aorta)
  • vascularitis/vasculitides/arteritis
  • acute ischemic syndrome
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • asthenia/fatigue/weakness
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • visual loss/blindness/amblyopia
  • chronic skin infection/ulcerations/ulcers/cancrum
  • thoracic/chest pain
  • respiratory rhythm disorder
  • pulmonary hypertension
  • aortic valve atresia/stenosis/narrowing/supra-aortic/supra-valvular stenosis
  • cardiomyopathy/hypertrophic/dilated
  • aortic root dilatation/dilation/aneurysm
  • angor pectoris/myocardial infarction
  • chronic arterial hypertension
  • gangrena/necrosis
  • facial pain/cephalalgia/migraine
  • seizures/epilepsy/absences/spasms/status epilepticus
  • anorexia
  • muscle weakness/flaccidity
  • myalgia/muscular pain
  • arthritis/synovitis/synovial proliferation
  • anaemia
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • retinopathy
  • transient amaurosis/acute visual trouble
  • hemoptysis
  • endocardium anomalies/fibroelastosis/endocarditis
  • mesenteric/intestinal infarction
  • transient cerebral ischemia/stroke
  • obnubilation/coma/lethargia/desorientation
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
  • articular/joint pain/arthralgia

HPO human phenotypes related to Takayasu's Arteritis:

(show all 40)
id Description Frequency HPO Source Accession
1 hypertensive crisis hallmark (90%) HP:0100735
2 abnormality of temperature regulation hallmark (90%) HP:0004370
3 vasculitis hallmark (90%) HP:0002633
4 aneurysm hallmark (90%) HP:0002617
5 weight loss hallmark (90%) HP:0001824
6 hyperhidrosis hallmark (90%) HP:0000975
7 abnormality of the aorta hallmark (90%) HP:0001679
8 skin ulcer typical (50%) HP:0200042
9 gangrene typical (50%) HP:0100758
10 chest pain typical (50%) HP:0100749
11 inflammatory abnormality of the eye typical (50%) HP:0100533
12 dilatation of the ascending aorta typical (50%) HP:0005111
13 myalgia typical (50%) HP:0003326
14 abnormal pattern of respiration typical (50%) HP:0002793
15 pulmonary hypertension typical (50%) HP:0002092
16 migraine typical (50%) HP:0002076
17 anorexia typical (50%) HP:0002039
18 anemia typical (50%) HP:0001903
19 coronary artery disease typical (50%) HP:0001677
20 abnormality of the aortic valve typical (50%) HP:0001646
21 hypertrophic cardiomyopathy typical (50%) HP:0001639
22 arthritis typical (50%) HP:0001369
23 muscle weakness typical (50%) HP:0001324
24 seizures typical (50%) HP:0001250
25 visual impairment typical (50%) HP:0000505
26 respiratory insufficiency typical (50%) HP:0002093
27 apnea typical (50%) HP:0002104
28 amaurosis fugax occasional (7.5%) HP:0100576
29 gastrointestinal infarctions occasional (7.5%) HP:0005244
30 reduced consciousness/confusion occasional (7.5%) HP:0004372
31 abnormality of the endocardium occasional (7.5%) HP:0004306
32 arthralgia occasional (7.5%) HP:0002829
33 cerebral ischemia occasional (7.5%) HP:0002637
34 neurological speech impairment occasional (7.5%) HP:0002167
35 hemoptysis occasional (7.5%) HP:0002105
36 retinopathy occasional (7.5%) HP:0000488
37 asthma occasional (7.5%) HP:0002099
38 recurrent respiratory infections occasional (7.5%) HP:0002205
39 feeding difficulties in infancy occasional (7.5%) HP:0008872
40 arteritis HP:0012089

Drugs & Therapeutics for Takayasu's Arteritis

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Drugs for Takayasu's Arteritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Omega 3 Fatty AcidNutraceuticalPhase 4912
2ImmunoglobulinsPhase 34477
3AntibodiesPhase 34477
4
AbataceptapprovedPhase 2139332348-12-610237
Synonyms:
CTLA4-Ig
CTLA4-IgG4m
 
CTLA4Ig
CTLA4IgG4m
Orencia
5
PrednisoneapprovedPhase 2126753-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
Juvason
 
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Perrigo Prednisone
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rayos
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
6
InfliximabapprovedPhase 2349170277-31-3
Synonyms:
Ig gamma-1 chain C region
 
Inflectra
Remicade
Remsima
7
AldesleukinapprovedPhase 238785898-30-2
Synonyms:
IL-2
Interleukin-2 precursor
 
Proleukin
T-cell growth factor
TCGF
8
Epoetin alfaapprovedPhase 1, Phase 2626113427-24-0
Synonyms:
Epogen
 
Erythropoietin precursor
Procrit
9Immunologic FactorsPhase 218483
10glucocorticoidsPhase 23896
11Immunosuppressive AgentsPhase 210422
12Antirheumatic AgentsPhase 28496
13Peripheral Nervous System AgentsPhase 218510
14Interleukin-2Phase 2487
15AnalgesicsPhase 29358
16Analgesics, Non-NarcoticPhase 25184
17HematinicsPhase 1, Phase 21121
18
Cyclophosphamideapproved, investigational264350-18-0, 6055-19-22907
Synonyms:
(+-)-Cyclophosphamide
(-)-Cyclophosphamide
(RS)-Cyclophosphamide
1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine
1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin
2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide
4-Hydroxy-cyclophosphan-mamophosphatide
50-18-0
60007-95-6
6055-19-2 (monohydrate)
75526-90-8
AC1L1EQQ
AI3-26198
ASTA
ASTA B518
Asta B 518
B 518
B-518
BRN 0011744
BSPBio_002099
Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester
C 0768
C07888
C7H15Cl2N2O2P
CB 4564
CB-4564
CCRIS 188
CHEBI:4027
CHEMBL32520
CHEMBL88
CID2907
CP
CPA
CTX
CY
Ciclofosfamida
Ciclofosfamida [INN-Spanish]
Ciclofosfamide
Ciclophosphamide
Ciclophosphamide [INN]
Clafen
Claphene
Cycloblastin
Cyclophosphamid
Cyclophosphamide
Cyclophosphamide (INN)
Cyclophosphamide (TN)
Cyclophosphamide (anhydrous form)
Cyclophosphamide (anhydrous)
Cyclophosphamide Monohydrate
Cyclophosphamide Sterile
Cyclophosphamide anhydrous
Cyclophosphamide, (+-)-Isomer
Cyclophosphamides
Cyclophosphamidum
Cyclophosphamidum [INN-Latin]
Cyclophosphan
Cyclophosphane
Cyclophosphanum
Cyclophosphoramide
Cyclostin
Cyklofosfamid
Cyklofosfamid [Czech]
Cytophosphan
Cytophosphane
Cytoxan
Cytoxan (TN)
Cytoxan Lyoph
D,L-Cyclophosphamide
D07760
DB00531
 
DivK1c_000246
EINECS 200-015-4
EU-0100238
Endoxan
Endoxan R
Endoxan-Asta
Endoxana
Endoxanal
Endoxane
Enduxan
Genoxal
HMS2090A12
HSDB 3047
Hexadrin
IDI1_000246
KBio1_000246
KBio2_001338
KBio2_003906
KBio2_006474
KBio3_001319
KBioGR_000888
KBioSS_001338
LS-1302
LS-99787
Ledoxina
Lopac-C-0768
Lopac0_000238
Lyophilized Cytoxan
Mitoxan
MolPort-001-783-420
N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
NCGC00015209-01
NCGC00015209-03
NCGC00015209-06
NCGC00091741-02
NCGC00091741-03
NCI-C04900
NCI60_002097
NINDS_000246
NSC 26271
NSC-26271
NSC26271
NSC273033
NSC273034
Neosar
Occupation, cyclophosphamide exposure
Procytox
RCRA waste no. U058
Rcra Waste Number U058
Rcra waste number U058
Revimmune
S1217_Selleck
SK 20501
SPBio_001071
STK177249
STOCK2S-91217
Semdoxan
Sendoxan
Senduxan
Spectrum2_001146
Spectrum3_000370
Spectrum4_000304
Spectrum5_000795
Spectrum_000858
UNII-6UXW23996M
WLN: T6MPOTJ BO BN2G2G
Zyklophosphamid
Zyklophosphamid [German]
bis(2-Chloroethyl)phosphami de cyclic propanolamide
bis(2-Chloroethyl)phosphamide cyclic propanolamide ester
cyclophosphamide
19
Methylprednisoloneapproved108283-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
A-methapred
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Depo-medrol
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Solu-medrol
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
20
Prednisoloneapproved108250-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
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D00472
D011239
DB00860
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Delta F
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Deltahydrocortisone
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Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
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Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
Flo-pred
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
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Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
MLS001304083
 
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
Millipred
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
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P0152_SIGMA
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Pred Forte
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Predate
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Predisolone Sodium Phosphate
Predne-Dome
Prednelan
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Prednicen
Predniliderm
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Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
21Neuroprotective Agents1376
22Methylprednisolone acetate1082
23Methylprednisolone Hemisuccinate1082
24Prednisolone hemisuccinate1082
25Protective Agents5651
26Prednisolone phosphate1082
27lenograstim1134
28Prednisolone acetate1082
29Anti-Inflammatory Agents8478
30Antineoplastic Agents, Hormonal4256
31Antilymphocyte Serum388
32Antiemetics3213
33Hormones, Hormone Substitutes, and Hormone Antagonists9988
34Cyclosporins873
35Gastrointestinal Agents6401
36Hormones11748
37Hormone Antagonists10002
38CalamusNutraceutical344
39Kavanutraceutical1329000-38-85281052

Interventional clinical trials:

(show all 26)
idNameStatusNCT IDPhase
1Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein LevelsTerminatedNCT00578578Phase 4
2Efficacy and Tolerance of Tocilizumab In Takayasu ArteritisNot yet recruitingNCT02101333Phase 3
3Abatacept for Treating Adults With Giant Cell Arteritis and Takayasu's ArteritisCompletedNCT00556439Phase 2
4Clinical Study of Anti-tumor Necrosis Factor Therapy in Patients With Takayasu ArteritisRecruitingNCT02457585Phase 2
5Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory DiseasesRecruitingNCT01988506Phase 2
6Erythropoetin Neuroprotection for Neonatal Cardiac SurgeryActive, not recruitingNCT00513240Phase 1, Phase 2
7Impact and Utility of PET Versus Clinical Score for the Assessment of Inflammatory Activity in Takayasu ArteritisCompletedNCT01532167
8Carotid Artery Neovascularization in Takayasu's and Giant Cell ArteritisCompletedNCT01795456
9Educational Needs of Patients With Systemic VasculitisCompletedNCT02190929
10Reproductive Health in Men and Women With VasculitisCompletedNCT02176070
11Vasculitis Illness Perception (VIP) StudyCompletedNCT02190916
12Impact of Vasculitis on Employment and IncomeCompletedNCT02476292
13Magnetic Resonance Angiography vs Ultrasonography in Systemic Large vEssel vasculitiSCompletedNCT02042092
14Cerebral Perfusion During Neonatal Cardiac SurgeryCompletedNCT01032876
15Determining Disease Activity Biomarkers in Individuals With Takayasu's ArteritisRecruitingNCT00315471
16Use of MRI and PET for Assessing Disease Activity in Takayasu's ArteritisRecruitingNCT00744952
17Exercise in Sjogren, Myositis and Takayasu's ArteritisRecruitingNCT01501019
18American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic VasculitisRecruitingNCT01066208
19Pediatric Vasculitis InitiativeRecruitingNCT02006134
20Vasculitis Pregnancy RegistryRecruitingNCT02593565
21One-Time DNA Study for VasculitisRecruitingNCT01241305
22Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune DiseasesActive, not recruitingNCT00006055
23Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence StudyActive, not recruitingNCT01663129
24Evaluation of Panel Reactive Antibody in Children Following Stage I Palliation for Hypoplastic Left Heart SyndromeActive, not recruitingNCT01135485
25VCRC Patient Contact Registry Patient-Reported Data Validation StudyEnrolling by invitationNCT02190942
26Aortic Arch ReconstructionTerminatedNCT00277940

Search NIH Clinical Center for Takayasu's Arteritis

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: takayasu arteritis

Genetic Tests for Takayasu's Arteritis

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Anatomical Context for Takayasu's Arteritis

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MalaCards organs/tissues related to Takayasu's Arteritis:

33
Heart, Skin, Bone, Breast, Liver, T cells, Prostate

Animal Models for Takayasu's Arteritis or affiliated genes

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MGI Mouse Phenotypes related to Takayasu's Arteritis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5IL12B, IL6, MMP2, MMP9, PTPN22, SELE
2MP:00053856.3CD40LG, CRP, F3, IL6, MMP2, MMP9
3MP:00053976.1CD40LG, F3, IL12B, IL6, MMP2, MMP3
4MP:00053765.7CD40LG, CRP, F3, IL12B, IL6, MMP2
5MP:00053875.1CD40LG, CRP, F3, IL12B, IL6, MMP2

Publications for Takayasu's Arteritis

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Articles related to Takayasu's Arteritis:

(show top 50)    (show all 572)
idTitleAuthorsYear
1
The Incidence of Hypersensitivity Reactions to Pegylated Asparaginase in Children With Acute Lymphoblastic Leukemia: A City-Wide Experience. (26558809)
2015
2
Spinocerebellar ataxia type 6 protein aggregates cause deficits in motor learning and cerebellar plasticity. (26063920)
2015
3
Circulating sclerostin in children and young adults with heritable bone disorders. (24512494)
2014
4
Fetal and Neonatal Health Consequences of Vertically Transmitted Hepatitis E Virus Infection. (24420778)
2014
5
Ghrelin protects human umbilical vein endothelial cells against high glucose-induced apoptosis via mTOR/P70S6K signaling pathway. (24287118)
2014
6
Clinicopathologic Characteristics and OutcomesA of Penile Cancer Treated at Tertiary Care Centers in the Western United States. (24210829)
2013
7
MYC/BCL2 double-hit high-grade B-cell lymphoma. (23939148)
2013
8
Prevalence of rabies in various species in yemen and risk factors contributing to the spread of the disease. (23984026)
2013
9
Effects of demographic factors, body mass index, alcohol drinking and smoking habits on irritable bowel syndrome: a case control study. (24116320)
2013
10
Characteristics and risk of syphilis diagnosis among HIV-infected male cohort: a population-based study in Houston, Texas. (24220358)
2013
11
Misdiagnosis of florid cemento-osseous dysplasia leading to unnecessary root canal treatment: a case report. (24010083)
2013
12
Dynamic alterations in integrin I+4 expression by hypoxia are involved in trophoblast invasion during early implantation. (21976114)
2012
13
Cell cycle-specific function of Ikaros in human leukemia. (22106042)
2012
14
An endoscopic endonsal transethmoidal approach to olfactory groove meningioma. (22076822)
2011
15
Gray matter volume decrements in preterm children with periventricular leukomalacia. (21386751)
2011
16
Contemporary threat of influenza virus infection]. (20369714)
2010
17
Amperometric glucose biosensor based on biocompatible poly(dimethylaminoethyl) methacrylate microparticles. (20441884)
2010
18
Degree of genetic homozygosity and distribution of AB0 blood types among patients with spina bifida occulta and spina bifida aperta. (22427757)
2010
19
Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons. (19903690)
2009
20
Myeloproliferative disorder therapy: assessment and management of adverse events--a dermatologist's perspective. (19468982)
2009
21
Multicenter study using paraffin-embedded tumor tissue testing PITX2 DNA methylation as a marker for outcome prediction in tamoxifen-treated, node-negative breast cancer patients. (18711169)
2008
22
Behavior of vascular endothelial growth factor and erythropoietin throughout the menstrual cycle in healthy women. (18161402)
2007
23
Expression pattern of leptin and leptin receptor (OB-R) in human gastric cancer. (17006991)
2006
24
A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners. (17018644)
2006
25
The somatostatin subtype-2 receptor antagonist, BIM-23627, improves the catabolic effects induced by long-term glucocorticoid treatment in the rat. (15582718)
2005
26
Photodynamic therapy for focal retinal pigment epithelial leaks secondary to central serous chorioretinopathy. (16325707)
2005
27
Normalization of low biotinidase activity in a child with biotin deficiency after biotin supplementation. (14707523)
2003
28
Vascular endothelial growth factor C mRNA expression correlates with stage of progression in patients with melanoma. (14676121)
2003
29
Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms. (11559542)
2001
30
Transgrediens et progrediens palmoplantar keratoderma (Greither's disease) with particular histopathologic findings. (10738633)
2000
31
Antioxidants attenuate nuclear factor-kappa B activation and tumor necrosis factor-alpha production in alcoholic hepatitis patient monocytes and rat Kupffer cells, in vitro. (10614719)
1999
32
Biosynthesis and degradation of bioactive fatty acid amides in human breast cancer and rat pheochromocytoma cells--implications for cell proliferation and differentiation. (9688276)
1998
33
Sensory regulation of immediate-early gene expression in mammalian visual cortex: implications for functional mapping and neural plasticity. (9164673)
1997
34
Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma. (9169129)
1997
35
Differential role of the low affinity neurotrophin receptor (p75) in retrograde axonal transport of the neurotrophins. (7541633)
1995
36
Involvement of human papillomavirus type 20 in epidermodysplasia verruciformis skin carcinogenesis. (8027315)
1994
37
C5A anaphylatoxin and its seven transmembrane-segment receptor. (8011297)
1994
38
Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients. (7820300)
1994
39
Oral adenoid squamous cell carcinoma: a report of three cases and review of the literature. (8492207)
1993
40
Functional integrity of benzodiazepine receptors of the geniculo-striate visual pathways in Creutzfeldt-Jakob disease. A pharmacological evoked potential study. (8380846)
1993
41
Tangier disease: isolation and characterization of LpA-I, LpA-II, LpA-I: A-II and LpA-IV particles from plasma. (8347683)
1993
42
Molecular cloning of rat growth inhibitory factor cDNA and the expression in the central nervous system. (8412560)
1993
43
Structure of the X-linked Kallmann syndrome gene and its homologous pseudogene on the Y chromosome. (1303284)
1992
44
Isolation and characterization of the human sucrase-isomaltase gene and demonstration of intestine-specific transcriptional elements. (1560017)
1992
45
Metabolic variables of cholesterol during squalene feeding in humans: comparison with cholestyramine treatment. (2246614)
1990
46
Degenerate binding of immunogenic peptides to HLA-DR proteins on B cell surfaces. (1707655)
1990
47
HTLV-1 associated tropical spastic paraparesis in an African patient residing in Belgium. (2730175)
1989
48
Placenta accreta. (14395248)
1955
49
50

Variations for Takayasu's Arteritis

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Expression for genes affiliated with Takayasu's Arteritis

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Search GEO for disease gene expression data for Takayasu's Arteritis.

Pathways for genes affiliated with Takayasu's Arteritis

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Pathways related to Takayasu's Arteritis according to GeneCards Suite gene sharing:

(show top 31)    (show all 32)
idSuper pathwaysScoreTop Affiliating Genes
19.8IL12B, IL6, TNF
29.8IL12B, IL6, TNF
39.8IL12B, IL6, TNF
49.6IL6, TNF, VCAM1
59.5HLA-DPB1, IL12B, IL6, TNF
6
Show member pathways
9.5CD40LG, HLA-DPB1, IL12B, TNF
79.4MMP3, MMP9, SELE
8
Show member pathways
9.4HLA-A, HLA-B, IL12B, IL6, TNF
99.3CD40LG, IL6, TNF, VCAM1
109.3IL6, MMP2, SELE
119.3HLA-DPB1, IL6, MMP3, TNF
129.3IL6, MMP2, MMP9
139.3IL6, MMP2, MMP9
149.2CD40LG, MMP2, MMP9
159.2CD40LG, HLA-A, HLA-B, MICA, VCAM1
16
Show member pathways
9.1HLA-A, HLA-B, HLA-DPB1, IL12B, IL6, TNF
179.1IL12B, IL6, SELE, TNF, VCAM1
18
Show member pathways
9.1CD40LG, TNF, TNFSF8
199.1MMP2, MMP3, MMP9
209.0CD40LG, IL6, SELE, TNF, VCAM1
219.0IL6, MMP2, MMP9, TNF
229.0IL6, MMP2, MMP9, TNF
238.9HLA-A, HLA-B, HLA-DPB1, IL6, TNF, VCAM1
24
Show member pathways
8.8MMP2, MMP3, MMP9, TNF
258.8CD40LG, HLA-A, HLA-B, HLA-DPB1, SELE, VCAM1
268.8IL12B, IL6, MMP2, MMP9, TNF
27
Show member pathways
8.6IL12B, IL6, MMP2, MMP9, TNF
28
Show member pathways
8.6CD40LG, HLA-A, HLA-B, HLA-DPB1, IL12B, IL6
298.6IL6, MMP3, MMP9, SELE, TNF, VCAM1
308.2F3, IL6, MMP2, SELE, TNF, VCAM1
31
Show member pathways
6.9F3, IL6, MMP2, MMP3, MMP9, SELE

GO Terms for genes affiliated with Takayasu's Arteritis

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Cellular components related to Takayasu's Arteritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.6CD40LG, IL6, VCAM1

Biological processes related to Takayasu's Arteritis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1protection from natural killer cell mediated cytotoxicityGO:004227010.6HLA-A, HLA-B
2epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.6IL6, TNF
3regulation of immunoglobulin secretionGO:005102310.5CD40LG, TNF
4negative regulation of lipid storageGO:001088810.4IL6, TNF
5leukocyte tethering or rollingGO:005090110.4TNF, VCAM1
6positive regulation of T cell mediated cytotoxicityGO:000191610.4HLA-A, HLA-B, IL12B
7leukocyte cell-cell adhesionGO:000715910.3CD40LG, VCAM1
8positive regulation of osteoclast differentiationGO:004567210.2IL12B, TNF
9antigen processing and presentationGO:001988210.2HLA-A, HLA-B, HLA-DPB1
10defense response to Gram-positive bacteriumGO:00508309.9CRP, HLA-A, IL6, TNF
11interferon-gamma-mediated signaling pathwayGO:00603339.9HLA-A, HLA-B, VCAM1
12cellular response to lipopolysaccharideGO:00712229.9IL12B, IL6, TNF
13cytokine-mediated signaling pathwayGO:00192219.7HLA-DPB1, IL12B, IL6, VCAM1
14response to lipopolysaccharideGO:00324969.0F3, IL6, PTPN22, SELE

Molecular functions related to Takayasu's Arteritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:004260510.1HLA-A, HLA-B
2metalloendopeptidase activityGO:00042228.8MMP2, MMP3, MMP9

Sources for Takayasu's Arteritis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet