CTEV
MCID: TLP001
MIFTS: 38

Talipes Equinovarus (CTEV) malady

Category: Rare diseases

Aliases & Classifications for Talipes Equinovarus

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Aliases & Descriptions for Talipes Equinovarus:

Name: Talipes Equinovarus 48 27
Talipes 48 27
Congenital Talipes Equinovarus 48
 
Clubfoot 48
Ctev 48

Classifications:



External Ids:

ICD1030 Q66.0

Summaries for Talipes Equinovarus

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NIH Rare Diseases:48 Talipes equinovarus is a congenital (present from birth) condition where the foot turns inward and downward. the cause of this condition is not known, although it may be passed down through families in some cases. this condition occurs in about 1 out of every 1,000 births. treatment may involve moving the foot into the correct position and using a cast to keep it there. this process is done in small increments over a period of time. in severe cases, surgery may be needed.  <span style="font-size: 16px;"> &lt;span style="font-size: 13px;"&gt; body {background-color: #ffffff; font-family: "times new roman"; font-size: 12pt;} &lt;/span&gt; </span> ]]> last updated: 2/27/2014

MalaCards based summary: Talipes Equinovarus, also known as talipes, is related to clubfoot and tarp syndrome. An important gene associated with Talipes Equinovarus is TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4). Affiliated tissues include bone, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

Wikipedia:71 Club foot or clubfoot, is a term for the medical condition congenital talipes equinovarus (CTEV). It is... more...

Related Diseases for Talipes Equinovarus

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Graphical network of the top 20 diseases related to Talipes Equinovarus:



Diseases related to talipes equinovarus

Symptoms & Phenotypes for Talipes Equinovarus

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MGI Mouse Phenotypes related to Talipes Equinovarus according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.6COL9A1, GLI3, TRPV4
2MP:00053719.2COL9A1, GLI3, HOXD13
3MP:00053918.1COL9A1, GLI3, HOXD13, TRPV4

Drugs & Therapeutics for Talipes Equinovarus

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Drugs for Talipes Equinovarus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AcetylcholineapprovedPhase 4, Phase 3, Phase 280551-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
2Botulinum ToxinsPhase 4, Phase 3, Phase 2697
3abobotulinumtoxinAPhase 4, Phase 3, Phase 2652
4Peripheral Nervous System AgentsPhase 4, Phase 3, Phase 223689
5onabotulinumtoxinAPhase 4, Phase 3, Phase 2652
6Neuromuscular AgentsPhase 4, Phase 3, Phase 21180
7Neurotransmitter AgentsPhase 4, Phase 3, Phase 218340
8Botulinum Toxins, Type APhase 4, Phase 3, Phase 2657
9Cholinergic AgentsPhase 4, Phase 3, Phase 23992
10incobotulinumtoxinAPhase 4, Phase 3, Phase 2662
11AnestheticsPhase 39596
12Pharmaceutical SolutionsPhase 28192
13HemagglutininsPhase 2121
14
Mentholapproved26062216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol
15Neuroserpin3
16Analgesics11733
17AstragalusNutraceutical55

Interventional clinical trials:

(show all 40)
idNameStatusNCT IDPhase
1Post Marketing Surveillance Study of DysportCompletedNCT00210431Phase 4
2Effects of Botulinum Neurotoxin Type A (BoNT/A) Free of Complexing Proteins in the Spastic Equinovarus FootRecruitingNCT03044080Phase 4
3Efficacy Study of Selective Tibial Neurotomy in the Treatment of the Spastic Equinovarus Foot Among Adult Hemiplegic PatientsCompletedNCT00825097Phase 3
4Study of GSK1358820 In Patients With Post-Stroke Lower Limb SpasticityCompletedNCT00460655Phase 3
5Treatment With Xeomin Versus Botox in Children With Spastic Equine and Equinovarus Foot Deformation in Pediatric Cerebral PalsyCompletedNCT02188277Phase 2
6Sucrose Analgesia in Infants Undergoing Casting for Club FootUnknown statusNCT01050088
7Effectiveness of Parents' Manipulation in Newborn With Talipes CalcaneusUnknown statusNCT01767662
8Genetic Disease Gene IdentificationUnknown statusNCT00916903
9Safety and Efficacy of the Universal Neonatal Foot Orthosis in the Treatment of Metatarsus Adductus (MTA)Unknown statusNCT01600183
10Clubfoot DNA RepositoryCompletedNCT00607191
11Exploring the Causes of Clubfoot Using Magnetic Resonance Imaging, MRICompletedNCT01088828
12Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot)CompletedNCT00474344
13Gait Analysis in Ponseti ClubfootCompletedNCT02022267
14Polyaxial Brace Fixing for the Treatment of Congenital ClubfootCompletedNCT02815306
15Outcomes of Compliance With Brace Wear in ClubfootCompletedNCT01481324
16Comparison of Casting Materials for the Treatment of Clubfoot Using the Ponseti MethodCompletedNCT01067651
17A Randomized Controlled Trial of Three Non-pharmacologic Analgesic Techniques for Casting of Clubfoot InfantsCompletedNCT02395185
18Treatment of Spastic Equinovarus Foot After StrokeCompletedNCT00199589
19Neuro-orthopaedic Surgery in the Treatment of the Spastic Equinovarus FootCompletedNCT01265238
20Impairments of Oral Language in Mobius SyndromeCompletedNCT00856531
21Bracing Compliance and Personality Traits: A Compliance Assessment Program for Scoliosis and ClubfeetRecruitingNCT02755766
22Using Botox to Treat Patients With Idiopathic ClubfootRecruitingNCT00474032
23Efficacy Analysis of Minimally Invasive Carroll's Technique in Treatment of Congenital Idiopathic ClubfootRecruitingNCT02815215Early Phase 1
24Pedobarographic Assessments of Clubfoot Treated PatientsRecruitingNCT00175708
25Prospective Evaluation of Treatment for ClubfootRecruitingNCT02257229
26Dynamic Evaluation of Ankle Joint and Muscle Mechanics in Children With Spastic Equinus Deformity Due to Cerebral PalsyRecruitingNCT02814786
27Effectiveness of Manual Manipulation With EPAT on Ankle Dorsiflexion and Dynamic Plantar PressureRecruitingNCT02233140
28Trial Readiness and Endpoint Assessment in Congenital Myotonic DystrophyRecruitingNCT03059264
29Talonavicular Arthrodesis and Surgical Treatment of Ankle and Varus FootRecruitingNCT02790346
30Extramembranous and Interosseous Technique of Tibialis Posterior Tendon TransferRecruitingNCT01751503
31Survey Study and Records Review of Treatment Outcomes in Freeman-Sheldon SyndromeRecruitingNCT01144741
32Duration of Brace Wear in Clubfoot Treatment - A Prospective Randomized TrialActive, not recruitingNCT01551264
33Efficacy of Botox in Patients With Idiopathic ClubfootActive, not recruitingNCT00152334
34A Double-Blind, Randomized Control Trial Comparing Botulinum Toxin Type A (Botox) and Placebo in the Treatment of Idiopathic ClubfootActive, not recruitingNCT00152347
35Osteopathic Approach Into Neonatology Ward: the NE-O ModelAvailableNCT01902563
36Determination of the Pathophysicologic Collagen Changes in the Diabetic Achilles TendonSuspendedNCT01382628
37Ankle Equinus Contracture Treated With Dynamic SplintingTerminatedNCT01238484
38The Effect of Botulinum Toxin A Injections on Ankle Dorsiflexion Following Internal Fixation of Tibial Pilon FracturesTerminatedNCT02051933
39Economic Evaluation of Clubfoot Treatment: One Centre's ExperienceWithdrawnNCT00475631
40Instep Plantar Fasciotomy With and Without Gastrocnemius RecessionWithdrawnNCT02287714

Search NIH Clinical Center for Talipes Equinovarus

Genetic Tests for Talipes Equinovarus

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Genetic tests related to Talipes Equinovarus:

id Genetic test Affiliating Genes
1 Talipes Equinovarus27
2 Talipes27

Anatomical Context for Talipes Equinovarus

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MalaCards organs/tissues related to Talipes Equinovarus:

36
Bone

Publications for Talipes Equinovarus

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Articles related to Talipes Equinovarus:

(show top 50)    (show all 235)
idTitleAuthorsYear
1
The hybrid method for the treatment of congenital talipes equinovarus: preliminary results on 92 consecutive feet. (28079742)
2017
2
Three novel missense mutations in the filamin B gene are associated with isolated congenital talipes equinovarus. (27395407)
2016
3
Fibula extension and correction of foot and ankle deformity to rectify post-osteomyelitis talipes equinovarus in a young adult: a case report and literature review. (27383298)
2016
4
Role of COL9A1 genetic polymorphisms in development of congenital talipes equinovarus in a Chinese population. (27819742)
2016
5
Congenital talipes equinovarus associated with hereditary congenital common peroneal nerve neuropathy: a literature review. (26588839)
2016
6
Birth prevalence of congenital talipes equinovarus in low- and middle-income countries: a systematic review and meta-analysis. (28000394)
2016
7
An Unusual Cause of Talipes Equinovarus: Agenesis of Leg Muscles. (27779489)
2016
8
Treatment of persistent forefoot adduction during ponseti method in treatment of idiopathic talipes equinovarus by minimal soft release. (27408483)
2016
9
A systematic review of association studies of common variants associated with idiopathic congenital talipes equinovarus (ICTEV) in humans in the past 30A years. (27386344)
2016
10
Surgical treatment of neglected congenital idiopathic talipes equinovarus after walking age in Eritrea: an Italo-Eritrean cooperation. (26965500)
2016
11
Congenital idiopathic talipes equinovarus before and after walking age: observations and strategy of treatment from a series of 88 cases. (26409466)
2015
12
Prenatal Ultrasound Diagnosis of Congenital Talipes Equinovarus in Bogota (Colombia) Between 2003 and 2012. (26361459)
2015
13
Prognostic Value of the Radiologic Appearance of the Navicular Ossification Center in Congenital Talipes Equinovarus. (26049641)
2015
14
A rare case of 3C disease: Ritscher-Schinzel syndrome presenting with recurrent talipes equinovarus. (25434475)
2015
15
Interventions for congenital talipes equinovarus (clubfoot). (26435670)
2015
16
Correcting Congenital Talipes Equinovarus in Children Using Three Different Corrective Methods: A Consort Study. (26181538)
2015
17
Comparative results of percutaneous Achilles tenotomy to combined open Achilles tenotomy with posterior capsulotomy in the correction of equinus deformity in congenital talipes equinovarus. (25690920)
2015
18
Open Achilles tenotomy and posterior capsulotomy for congenital talipes equinovarus. (26156730)
2015
19
Patient-Based Long-Term Results of the Surgical Treatment of Congenital Talipes Equinovarus. (26634284)
2015
20
Comment on critical region for talipes equinovarus in patients with 5q23 deletions. (25676702)
2015
21
Talipes equinovarus (clubfoot): neglected for 47 years and subsequent treatment. (24859734)
2014
22
Epithelioid hemangioma of distal femoral epiphysis in a patient with congenital talipes equinovarus. (24763238)
2014
23
Osteopathic manipulative treatment of congenital talipes equinovarus: A case report. (24411143)
2014
24
Does the Ponseti technique affect the vascular development in patients with congenital talipes equinovarus? (25229798)
2014
25
Is congenital talipes equinovarus a risk factor for pathological dysplasia of the hip? : a 21-year prospective, longitudinal observational study. (25371473)
2014
26
Congenital Talipes Equinovarus: Frequency of Associated Malformations not Identified by Prenatal Ultrasound. (25394569)
2014
27
Interventions for congenital talipes equinovarus (clubfoot). (25117413)
2014
28
3D MRI analysis of the lower legs of treated idiopathic congenital talipes equinovarus (clubfoot). (23382871)
2013
29
Fertile eunuch syndrome in association with biventricular noncompaction, bicuspid aortic valve, severe aortic stenosis, and talipes equinovarus. (23678225)
2013
30
Consanguineous marriage and increased risk of idiopathic congenital talipes equinovarus: a case-control study in a rural area. (23482273)
2013
31
Congenital idiopathic talipes equinovarus: an evaluation in infants treated by the Ponseti method. (24142617)
2013
32
SOX9 overexpression plays a potential role in idiopathic congenital talipes equinovarus. (23254326)
2013
33
Copy number analysis of 413 isolated talipes equinovarus patients suggests role for transcriptional regulators of early limb development. (22892537)
2013
34
Outpatient taping in the treatment of idiopathic congenital talipes equinovarus. (23365041)
2013
35
The inter-relationship of clinical parameters in congenital talipes equinovarus: relevance to pathological anatomy and clinical classification. (23450265)
2012
36
Correlation of foot bimalleolar angle with Pirani score to assess the severity of congenital talipes equinovarus deformity. (21912337)
2012
37
Assessment of calf volume in Congenital Talipes Equinovarus by computer analysed digital photography. (22385530)
2012
38
Possible role of GLI3 gene in the pathogenesis of idiopathic congenital talipes equinovarus]. (22678783)
2012
39
Congenital talipes equinovarus: an epidemiological study in Sicily. (22489891)
2012
40
Value of the fetal plantar shape in prenatal diagnosis of talipes equinovarus. (22733848)
2012
41
A single-center prospective evaluation of the Ponseti method in nonidiopathic congenital talipes equinovarus. (22892629)
2012
42
Assessment of talipes equinovarus treated by Ponseti technique: three-year preliminary report. (22387138)
2012
43
Prenatal detection and postnatal outcome of congenital talipes equinovarus in 106 fetuses. (22580510)
2012
44
Interventions for congenital talipes equinovarus (clubfoot). (22513960)
2012
45
Paralytic congenital talipes equinovarus of unknown origin: A new entity. Multicenter study of 42A cases. (22818425)
2012
46
Parental consanguinity and associated factors in congenital talipes equinovarus. (21920728)
2012
47
Expression of COL9A1 gene and its polymorphism in children with idiopathic congenital talipes equinovarus]. (21672422)
2011
48
Talipes equinovarus as leading symptom of congenital myotonic dystrophy type 2. (21462219)
2011
49
Simultaneous correction of congenital vertical talus and talipes equinovarus using the Ponseti method. (20797881)
2011
50
Management of congenital talipes equinovarus using the Ponseti method: a systematic review. (21911524)
2011

Variations for Talipes Equinovarus

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Clinvar genetic disease variations for Talipes Equinovarus:

5
id Gene Variation Type Significance SNP ID Assembly Location
1TRPV4NM_ 021625.4(TRPV4): c.947G> A (p.Arg316His)SNVPathogenicrs387906905GRCh37Chr 12, 110236624: 110236624

Expression for genes affiliated with Talipes Equinovarus

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Search GEO for disease gene expression data for Talipes Equinovarus.

Pathways for genes affiliated with Talipes Equinovarus

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GO Terms for genes affiliated with Talipes Equinovarus

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Biological processes related to Talipes Equinovarus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1anterior/posterior pattern specificationGO:00099529.6GLI3, HOXD13
2embryonic digit morphogenesisGO:00427339.6GLI3, HOXD13
3embryonic limb morphogenesisGO:00303269.5GLI3, HOXD13
4limb morphogenesisGO:00351089.5GLI3, HOXD13
5pattern specification processGO:00073899.0GLI3, HOXD13

Sources for Talipes Equinovarus

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet