MCID: TLP001
MIFTS: 48

Talipes Equinovarus malady

Rare diseases category

Aliases & Classifications for Talipes Equinovarus

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Talipes Equinovarus, Aliases & Descriptions:

Name: Talipes Equinovarus 41 22
Congenital Talipes Equinovarus 41
Clubfoot 41
 
Talipes 41
Ctev 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

ICD1025 Q66.0

Summaries for Talipes Equinovarus

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NIH Rare Diseases:41 Talipes equinovarus is a congenital (present from birth) condition where the foot turns inward and downward. the cause of this condition is not known, although it may be passed down through families in some cases. this condition occurs in about 1 out of every 1,000 births. treatment may involve moving the foot into the correct position and using a cast to keep it there. this process is done in small increments over a period of time. in severe cases, surgery may be needed.  <span style="font-size: 16px;"> &lt;span style="font-size: 13px;"&gt; body {background-color: #ffffff; font-family: "times new roman"; font-size: 12pt;} &lt;/span&gt; </span> ]]> last updated: 2/27/2014

MalaCards based summary: Talipes Equinovarus, also known as congenital talipes equinovarus, is related to clubfoot and polydactyly. An important gene associated with Talipes Equinovarus is HOXD13 (homeobox D13), and among its related pathways are EGFR Signaling Pathway and Activation of caspases through apoptosome-mediated cleavage. The compounds d-api and z-dqmd-fmk have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are taste/olfaction and pigmentation.

Wikipedia:63 Club foot or clubfoot, also called congenital talipes equinovarus (CTEV), is a congenital deformity... more...

Related Diseases for Talipes Equinovarus

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Diseases related to Talipes Equinovarus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 359)
idRelated DiseaseScoreTop Affiliating Genes
1clubfoot31.4HOXD10, HOXD13, COL9A1, GLI3, SLC26A2
2polydactyly30.4HOXD12, HOXD13, GLI3
3syndactyly30.3GLI3, HOXD13, HOXD12
4brachydactyly-syndactyly syndrome10.6HOXD13
5tarp syndrome10.5
6myocardial infarction10.4CFH
7myotonic dystrophy10.4
8pseudoachondroplasia10.4SLC26A2, COL9A1
9multiple epiphyseal dysplasia10.3COL9A1, SLC26A2
10acromelic frontonasal dysostosis10.3
11myelomeningocele10.3
12otosclerosis10.2COL1A1, SLC26A2
13pseudohypoaldosteronism, type iie10.2
14short stature robin sequence cleft mandible hand anomalies clubfoot10.2
15familial clubfoot due to 17q23.1q23.2 microduplication10.2
16familial clubfoot due to pitx1 point mutation10.2
17familial clubfoot due to 5q31 microdeletion10.2
18intervertebral disc disease10.2COL1A1
19autoimmune lymphoproliferative syndrome10.2CASP10, CASP8
20transitional cell carcinoma10.2NAT1, NAT2, APAF1
21pitx1-related congenital clubfoot10.2
22familial clubfoot with or without associated lower limb anomalies10.2
23intellectual deficit unusual facies talipes hand anomalies10.2
24cholangiocarcinoma10.1CASP9, NAT1, NAT2
25systemic scleroderma10.1COL1A1
26spondyloepimetaphyseal dysplasia with joint laxity, type 1, with or without fractures10.1
27ehlers-danlos syndrome, progeroid type, 210.1
28ehlers-danlos syndrome, type vi10.1
29schwartz-jampel syndrome, type 110.1
30dyssegmental dysplasia, silverman-handmaker type10.1
31spinal muscular atrophy, distal, autosomal recessive, 410.1
32desmosterolosis10.1
33meier-gorlin syndrome 110.1
34cousin syndrome10.1
35thrombocytopenia-absent radius syndrome10.1
36acrofacial dysostosis 1, nager type10.1
37craniofacial dysmorphism, skeletal anomalies, and mental retardation syndrome10.1
38martsolf syndrome10.1
39chromosome 1q41-q42 deletion syndrome10.1
40vertical talus, congenital10.1
41chromosome 2q31.1 duplication syndrome10.1
42glass syndrome10.1
43scapuloperoneal syndrome, neurogenic, kaeser type10.1
44arthrogryposis, distal, type 5d10.1
45ullrich congenital muscular dystrophy10.1
46larsen syndrome10.1
47atelosteogenesis, type i10.1
48atelosteogenesis, type iii10.1
49adams-oliver syndrome 110.1
50bruck syndrome 210.1

Graphical network of the top 20 diseases related to Talipes Equinovarus:



Diseases related to talipes equinovarus

Symptoms for Talipes Equinovarus

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Drugs & Therapeutics for Talipes Equinovarus

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Drug clinical trials:

Search ClinicalTrials for Talipes Equinovarus

Search NIH Clinical Center for Talipes Equinovarus

Genetic Tests for Talipes Equinovarus

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Genetic tests related to Talipes Equinovarus:

id Genetic test Affiliating Genes
1 Talipes Equinovarus22

Anatomical Context for Talipes Equinovarus

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MalaCards organs/tissues related to Talipes Equinovarus:

31
Bone

Animal Models for Talipes Equinovarus or affiliated genes

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MGI Mouse Phenotypes related to Talipes Equinovarus:

35 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.3GLI3, CASP9, CASP3
2MP:00011868.4CFH, COL1A1, BCL2, CASP3, GLI3
3MP:00053778.2APAF1, WNT7A, COL1A1, COL9A1, BCL2, CASP3
4MP:00053678.1HOXD10, HOXD13, CFH, BCL2, CASP8, CASP3
5MP:00053828.0APAF1, COL1A1, BCL2, CASP3, CASP9, GLI3
6MP:00053718.0HOXD10, HOXD12, HOXD13, APAF1, WNT7A, COL1A1
7MP:00107717.8HOXD13, WNT7A, COL1A1, BCL2, CASP8, CASP3
8MP:00053807.5HOXD12, HOXD13, APAF1, NAT1, WNT7A, COL1A1
9MP:00053817.5HOXD12, HOXD13, APAF1, COL1A1, BCL2, CASP3
10MP:00053797.5HOXD13, APAF1, COL1A1, BCL2, CASP8, CASP3
11MP:00053907.4APAF1, HOXD13, HOXD12, HOXD10, WNT7A, COL1A1
12MP:00053887.4APAF1, COL1A1, BCL2, CASP8, CASP3, CASP9
13MP:00053867.1HOXD10, APAF1, WNT7A, FHL1, COL1A1, BCL2
14MP:00053787.1HOXD13, FHL1, COL1A1, BCL2, CASP8, CASP3
15MP:00053697.0HOXD10, HOXD12, HOXD13, COL1A1, BCL2, CASP8
16MP:00053846.9BCL2, COL1A1, APAF1, HOXD10, CASP8, CASP3
17MP:00053876.8CFH, APAF1, COL1A1, COL9A1, BCL2, CASP8
18MP:00053896.6HOXD10, HOXD12, HOXD13, APAF1, NAT2, NAT1
19MP:00053916.6HOXD13, CFH, APAF1, NAT1, WNT7A, FHL1
20MP:00053856.6CFH, APAF1, WNT7A, FHL1, COL1A1, BCL2
21MP:00053766.5CFH, NAT2, NAT1, FHL1, COL1A1, COL9A1
22MP:00107685.4WNT7A, APAF1, CFH, HOXD13, HOXD12, HOXD10
23MP:00036315.1GLI3, HOXD10, HOXD12, HOXD13, CFH, APAF1

Publications for Talipes Equinovarus

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Articles related to Talipes Equinovarus:

(show top 50)    (show all 213)
idTitleAuthorsYear
1
Interventions for congenital talipes equinovarus (clubfoot). (25117413)
2014
2
Congenital Talipes Equinovarus: Frequency of Associated Malformations not Identified by Prenatal Ultrasound. (25394569)
2014
3
Does the Ponseti technique affect the vascular development in patients with congenital talipes equinovarus? (25229798)
2014
4
Epithelioid hemangioma of distal femoral epiphysis in a patient with congenital talipes equinovarus. (24763238)
2014
5
Osteopathic manipulative treatment of congenital talipes equinovarus: A case report. (24411143)
2014
6
Congenital idiopathic talipes equinovarus: an evaluation in infants treated by the Ponseti method. (24142617)
2013
7
Possible role of GLI3 gene in the pathogenesis of idiopathic congenital talipes equinovarus]. (22678783)
2012
8
The inter-relationship of clinical parameters in congenital talipes equinovarus: relevance to pathological anatomy and clinical classification. (23450265)
2012
9
Comparison of Ponseti versus surgical treatment in congenital talipes equinovarus. (21680202)
2011
10
Management of congenital talipes equinovarus using the Ponseti method: a systematic review. (21911524)
2011
11
The effect of neuromuscular electrical stimulation on congenital talipes equinovarus following correction with the Ponseti method: a pilot study. (20581693)
2010
12
Congenital talipes equinovarus associated with myotonic dystrophy type 2. (20665517)
2010
13
A new flexible brace used in the Ponseti treatment of talipes equinovarus. (19471177)
2008
14
Apoptotic gene analysis in idiopathic talipes equinovarus (clubfoot). (17534194)
2007
15
Histologic and histochemical analysis of muscle specimens in idiopathic talipes equinovarus. (16439910)
2006
16
Early results of a physiotherapist-delivered Ponseti service for the management of idiopathic congenital talipes equinovarus foot deformity. (16877611)
2006
17
Wound problems in surgery for talipes equinovarus. (16286376)
2005
18
Variation in CASP10 gene is associated with idiopathic talipes equinovarus. (16199938)
2005
19
Radiographic assessment of congenital talipes equinovarus: strapping versus forced dorsiflexion. (16365488)
2005
20
Talipes equinovarus in Western Australia. (12675786)
2003
21
Peritalar release in the treatment of congenital talipes equinovarus clubfoot. (12056243)
2001
22
Evaluation of foot bimalleolar angle in the management of congenital talipes equinovarus. (11176354)
2001
23
Resistant talipes equinovarus associated with congenital constriction band syndrome. (10739290)
2000
24
Somatosensory evoked potentials as a means of assessing neurological abnormality in congenital talipes equinovarus. (10981930)
2000
25
Epidemiology and genetic theories in the etiology of congenital talipes equinovarus. (10431636)
1999
26
MRI multiplanar reconstruction in the assessment of congenital talipes equinovarus. (10199904)
1999
27
Congenital talipes equinovarus in spina bifida: treatment and results. (8906652)
1996
28
Intraoperative ultrasound for evaluation of reduction in congenital talipes equinovarus. (7719835)
1995
29
Relationship between acquired spastic talipes equinovarus and dystonia musculorum deformans. (8416347)
1993
30
Seasonal variation in the incidence of congenital talipes equinovarus. (2071648)
1991
31
Risk indicators for talipes equinovarus in Washington State, 1987-1989. (1912045)
1991
32
Assessment in congenital talipes equinovarus. (2210529)
1990
33
Congenital talipes equinovarus. (2391207)
1990
34
Results of surgical treatment of talipes equinovarus congenita. (2805484)
1989
35
Congenital talipes equinovarus. (3647366)
1987
36
Prevalence and management of congenital club-feet (talipes equinovarus) in Zambia. (4006815)
1985
37
A higher incidence of congenital structural talipes equinovarus in gypsies. (6840781)
1983
38
Talipes equinovarus. (6554645)
1983
39
Surgical management of resistant congenital talipes equinovarus deformities. (7085691)
1982
40
HLA and clubfoot (idiopathic talipes equinovarus). (7071822)
1982
41
Early Dwyer operation in talipes equinovarus. (7471561)
1981
42
Management of congenital talipes equinovarus. (4809545)
1974
43
Practical considerations in the early treatment of congenital talipes equinovarus. (5012585)
1972
44
Congenital talipes equinovarus--fifteen years of surgical treatment. (5804493)
1969
45
Severe congenital talipes equinovarus. (5909063)
1966
46
THE GENETICS OF TALIPES EQUINOVARUS. (14133340)
1964
47
Recurring congenital talipes equinovarus. (13806063)
1960
48
Congenital talipes equinovarus. (13442744)
1957
49
Talipes equinovarus. (18131349)
1949
50
Symmetrical talipes equinovarus in identical twins. (18115536)
1949

Variations for Talipes Equinovarus

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Expression for genes affiliated with Talipes Equinovarus

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Search GEO for disease gene expression data for Talipes Equinovarus.

Pathways for genes affiliated with Talipes Equinovarus

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Pathways related to Talipes Equinovarus according to GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CASP9, CASP10, CASP3
2
Show member pathways
9.4CASP9, CASP3, APAF1
3
Show member pathways
Apoptosis and survival Lymphotoxin beta receptor signaling58
9.4CASP9, CASP3, APAF1
4
Show member pathways
9.4APAF1, CASP3, CASP9
59.4APAF1, CASP3, CASP9
6
Show member pathways
9.4APAF1, CASP3, CASP9
7
Show member pathways
Catalytic cycle of mammalian FMOs36
9.2NAT2, NAT1, BCL2
89.2CASP9, CASP3, CASP8
99.0CASP8, CASP3, CASP10, CASP9
10
Show member pathways
9.0CASP9, CASP10, CASP3, CASP8
11
Show member pathways
9.0CASP9, CASP10, CASP3, CASP8
129.0APAF1, CASP8, CASP3, CASP9
138.9BID, CASP8, BCL2
148.9APAF1, BCL2, CASP10, BID
15
Show member pathways
TRAIL signaling pathway36
8.8CASP8, CASP3, CASP10, BID
168.8CASP9, CASP3, BCL2, APAF1
17
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
8.8APAF1, BCL2, CASP3, CASP9
18
Show member pathways
8.7CASP8, CASP3, CASP9, BID
19
Show member pathways
8.6BCL2, CASP8, CASP3, CASP9
20
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
8.6BCL2, CASP8, CASP3, CASP9
21
Show member pathways
8.4BID, CASP9, CASP3, CASP8, APAF1
228.4APAF1, CASP8, CASP3, CASP9, BID
23
Show member pathways
8.4APAF1, CASP8, CASP3, CASP9, BID
24
Show member pathways
Alzheimers Disease36
8.4APAF1, CASP8, CASP3, CASP9, BID
25
Show member pathways
8.4APAF1, CASP8, CASP3, CASP9, BID
26
Show member pathways
DNA damage response36
8.4APAF1, CASP8, CASP3, CASP9, BID
27
Show member pathways
8.4BCL2, CASP8, CASP3, CASP10, CASP9
28
Show member pathways
8.4CASP9, CASP10, CASP3, CASP8, BCL2
29
Show member pathways
8.4BCL2, CASP8, CASP3, CASP10, CASP9
30
Show member pathways
8.4CASP9, CASP10, CASP3, CASP8, BCL2
31
Show member pathways
8.3APAF1, BCL2, CASP8, CASP9, BID
32
Show member pathways
8.3BCL2, CASP3, CASP10, CASP9, BID
33
Show member pathways
8.2APAF1, CASP8, CASP3, CASP10, CASP9, BID
34
Show member pathways
Amyotrophic lateral sclerosis (ALS)36
8.2APAF1, BCL2, CASP3, CASP9, BID
35
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.1APAF1, BCL2, CASP8, CASP3, CASP10, CASP9
368.1WNT7A, BCL2, CASP8, CASP3, CASP10, CASP9
378.1BCL2, CASP8, CASP3, CASP9, BID
38
Show member pathways
7.8APAF1, BCL2, CASP8, CASP3, CASP9, BID
39
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways58
7.6BID, APAF1, BCL2, CASP8, CASP3, CASP10
40
Show member pathways
7.6APAF1, BCL2, CASP8, CASP3, CASP10, CASP9
41
Show member pathways
FAS pathway and Stress induction of HSP regulation36
Apoptosis and survival FAS signaling cascades58
Caspase cascade in apoptosis36
7.6APAF1, BCL2, CASP8, CASP3, CASP10, CASP9
42
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
7.6CASP9, CASP10, CASP3, CASP8, BCL2, APAF1
43
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
7.6APAF1, BCL2, CASP8, CASP3, CASP10, CASP9
447.6APAF1, BCL2, CASP8, CASP3, CASP10, CASP9
45
Show member pathways
7.6APAF1, BCL2, CASP8, CASP3, CASP10, CASP9
46
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
7.6APAF1, BCL2, CASP8, CASP3, CASP10, CASP9
477.6APAF1, BCL2, CASP8, CASP3, CASP10, CASP9
487.6APAF1, BCL2, CASP8, CASP3, CASP10, CASP9
497.5WNT7A, BCL2, CASP8, CASP3, CASP9, BID
50
Show member pathways
6.9APAF1, COL1A1, COL9A1, BCL2, CASP8, CASP3

Compounds for genes affiliated with Talipes Equinovarus

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Compounds related to Talipes Equinovarus according to GeneCards Suite gene sharing:

(show top 50)    (show all 158)
idCompoundScoreTop Affiliating Genes
1d-api439.4CASP9, CASP3, CASP8
2z-dqmd-fmk59 2810.4CASP8, CASP3, CASP10, CASP9
3z-devd-fmk59 2810.4CASP8, CASP9, CASP3, CASP10
4az 10417808599.4CASP8, CASP3, CASP10, CASP9
52-chlorodeoxyadenosine439.2CASP9, APAF1, BCL2, CASP8
6cardiolipin43 1210.1CASP9, BID, CFH, CASP8
7oridonin439.1CASP9, BCL2, CASP3
8bongkrekic acid439.0BCL2, CASP8, CASP9, CASP3
9beta-lapachone439.0CASP3, BCL2, CASP9
10parthenolide43 210.0BID, CASP9, CASP3, CASP8
11shikonin439.0CASP9, CASP3, CASP8, BCL2
12betulinic acid43 2810.0CASP9, BCL2, CASP8, CASP3
13vitamin e succinate438.9CASP9, CASP3, CASP8, BCL2
14sulindac sulfide438.9BCL2, CASP8, CASP3, CASP9
15triptolide438.9BCL2, CASP3, CASP9, CASP8
16indole-3-carbinol438.9CASP8, CASP9, BCL2, CASP3
17dutp438.8CASP9, CASP3, CASP8, BCL2
18sulforaphane438.8CASP9, CASP8, CASP3, BCL2
19z-vad-fmk43 599.8CASP9, CASP8, BCL2, CASP3, CASP10
20depsipeptide438.8BCL2, CASP8, CASP9, CASP3
212-methoxyestradiol43 59 2410.7CASP8, BCL2, BID, CASP9
22celecoxib43 59 28 49 24 1213.7CASP8, CASP9, BCL2, APAF1, CASP3
23n-(4-hydroxyphenyl)retinamide438.7CASP9, CASP3, CASP8, BCL2
24lactacystin438.7CASP3, CASP9, CASP8, BCL2, APAF1
25fludarabine43 49 1210.6BID, CASP8, BCL2, APAF1
264,6-diamidino-2-phenylindole438.5BCL2, CASP8, CASP3, CASP9, BID
27sanguinarine438.5BCL2, CASP8, CASP3, CASP9, BID
28phenethyl isothiocyanate2 439.5CASP9, CASP3, CASP8, BCL2, BID
29cd 437438.5BID, BCL2, CASP3, CASP8, CASP9
30suberoylanilide hydroxamic acid438.5BCL2, CASP8, CASP3, CASP9, BID
31flavopiridol43 129.4CASP9, CASP8, BCL2, CASP3, BID
32gemcitabine43 49 1210.4CASP3, CASP9, CASP8, BCL2, BID
33sp 60012543 599.4CASP8, CASP3, BCL2, BID, CASP9
34mg 13243 599.3CASP9, CASP8, BID, BCL2, CASP3
35noxa438.3CASP8, APAF1, CASP3, CASP9, BID, BCL2
36bortezomib43 49 1210.3CASP3, CASP8, BCL2, APAF1, CASP9, BID
37adpribose438.3BID, CASP3, BCL2, APAF1, CASP9, CASP8
38resveratrol43 59 24 1211.2BID, CASP9, CASP3, CASP8, BCL2, APAF1
39camptothecin43 59 1210.2CASP8, APAF1, BCL2, CASP3, CASP9, BID
40phosphatidylserine43 28 1210.2CASP3, CASP8, BID, CASP9, BCL2, APAF1
41etoposide43 49 59 1211.2APAF1, BCL2, CASP3, CASP9, BID, CASP8
42docetaxel43 49 59 1211.1BID, CASP3, CASP9, CASP8, BCL2, NAT2
43curcumin438.1CASP8, BID, CASP9, CASP3, BCL2, NAT1
44doxorubicin43 49 1210.0BCL2, CASP3, CASP8, CASP9, BID, APAF1
45imatinib43 49 129.9CASP8, CASP3, BID, BCL2, COL1A1
46dexamethasone43 49 28 1210.9APAF1, CASP9, SLC26A2, CASP8, CFH, NAT2
47ceramide437.8BID, CASP9, CASP3, BCL2, CASP8
48paclitaxel43 49 129.8BID, APAF1, NAT1, BCL2, CASP8, CASP3
49cisplatin43 49 59 1210.4CASP8, BCL2, CASP3, CASP10, APAF1, BID
50cysteine437.0CFH, CASP9, SLC26A2, BID, CASP10, CASP3

GO Terms for genes affiliated with Talipes Equinovarus

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Cellular components related to Talipes Equinovarus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apoptosomeGO:004329310.0APAF1, CASP9
2ripoptosomeGO:00973429.9CASP8, CASP10
3CD95 death-inducing signaling complexGO:00312659.8CASP8, CASP10
4endoplasmic reticulum lumenGO:00057889.5COL9A1, COL1A1, WNT7A
5mitochondrial outer membraneGO:00057418.6BID, CASP8, BCL2
6cytosolGO:00058296.6GLI3, APAF1, NAT2, NAT1, FHL1, BCL2
7nucleusGO:00056346.4HOXD10, HOXD12, HOXD13, APAF1, FHL1, BCL2

Biological processes related to Talipes Equinovarus according to GeneCards Suite gene sharing:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1proximal/distal pattern formationGO:000995410.2GLI3, HOXD10
2anterior/posterior pattern specificationGO:000995210.2GLI3, HOXD13, HOXD10
3response to cobalt ionGO:003202510.1CASP8, CASP9
4signal transduction in response to DNA damageGO:00427709.9BID, CASP9
5platelet formationGO:00302209.9CASP3, CASP9
6xenobiotic metabolic processGO:00068059.9SLC26A2, NAT1, NAT2
7negative regulation of G1/S transition of mitotic cell cycleGO:020001349.8BCL2, FHL1
8activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cGO:00086359.8CASP9, CASP3, APAF1
9activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.7BID, CASP8, APAF1
10apoptotic signaling pathwayGO:00971909.6CASP8, CASP3, CASP10
11intrinsic apoptotic signaling pathway in response to oxidative stressGO:00086319.6CASP3, BCL2
12B cell homeostasisGO:00017829.6BCL2, CASP3
13extracellular matrix disassemblyGO:00226179.6CASP3, COL9A1, COL1A1
14execution phase of apoptosisGO:00971949.5CASP3, CASP8
15regulation of apoptotic processGO:00429819.5CASP9, CASP10, CASP3, APAF1
16glial cell apoptotic processGO:00343499.5CASP3, CASP9, BID
17heart developmentGO:00075079.5CASP8, CASP3, GLI3
18T cell homeostasisGO:00430299.4CASP3, BCL2
19response to tumor necrosis factorGO:00346129.4CASP8, CASP3
20apoptotic DNA fragmentationGO:00063099.4CASP3, APAF1
21embryonic digit morphogenesisGO:00427339.3HOXD12, HOXD13, WNT7A, GLI3
22positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:019007409.3BCL2, CASP8, BID
23skeletal system developmentGO:00015019.3COL1A1, HOXD13, HOXD12
24positive regulation of apoptotic processGO:00430659.2APAF1, CASP3, CASP9, BID
25release of cytochrome c from mitochondriaGO:00018369.2BID, CASP3, BCL2
26cellular response to DNA damage stimulusGO:00069749.1BCL2, CASP3, CASP9
27neuron apoptotic processGO:00514029.0BID, CASP3, BCL2, APAF1
28response to estradiolGO:00323558.9WNT7A, COL1A1, CASP8, CASP9, BID
29innate immune responseGO:00450878.8CFH, BCL2, CASP8, CASP10, CASP9
30negative regulation of apoptotic processGO:00430668.8GLI3, CASP3, BCL2, WNT7A
31extrinsic apoptotic signaling pathway via death domain receptorsGO:00086258.8BCL2, CASP8, CASP3, BID
32intrinsic apoptotic signaling pathwayGO:00971938.2BID, CASP9, CASP3, CASP8, BCL2, APAF1
33apoptotic processGO:00069158.0APAF1, BCL2, CASP8, CASP3, CASP10, CASP9

Molecular functions related to Talipes Equinovarus according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:009719910.0CASP8, CASP10
2arylamine N-acetyltransferase activityGO:000406010.0NAT2, NAT1
3death effector domain bindingGO:00358779.9CASP10, CASP8
4cysteine-type endopeptidase activity involved in apoptotic processGO:00971539.4CASP8, CASP3
5cysteine-type endopeptidase activityGO:00041979.2CASP9, CASP10, CASP3, CASP8
6peptidase activityGO:00082338.9CASP9, CASP3, CASP8
7identical protein bindingGO:00428028.9RBM10, BCL2, COL1A1, APAF1
8ubiquitin protein ligase bindingGO:00316258.8BCL2, CASP8, CASP10, BID
9protein bindingGO:00055156.0BCL2, COL1A1, FHL1, APAF1, CFH, CASP8

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
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35MGI
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39NDF-RT
42NINDS
43Novoseek
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51QIAGEN
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60UMLS
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