CTEV
MCID: TLP001
MIFTS: 38

Talipes Equinovarus (CTEV) malady

Categories: Rare diseases

Aliases & Classifications for Talipes Equinovarus

Aliases & Descriptions for Talipes Equinovarus:

Name: Talipes Equinovarus 50 29
Talipes 50 29
Congenital Talipes Equinovarus 50
Clubfoot 50
Ctev 50

Classifications:



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ICD10 33 Q66.0

Summaries for Talipes Equinovarus

NIH Rare Diseases : 50 talipes equinovarus is a congenital (present from birth) condition where the foot turns inward and downward. the cause of this condition is not known, although it may be passed down through families in some cases. this condition occurs in about 1 out of every 1,000 births. treatment may involve moving the foot into the correct position and using a cast to keep it there. this process is done in small increments over a period of time. in severe cases, surgery may be needed.  <span style="font-size: 16px;"> &lt;span style="font-size: 13px;"&gt; body {background-color: #ffffff; font-family: "times new roman"; font-size: 12pt;} &lt;/span&gt; </span> ]]> last updated: 2/27/2014

MalaCards based summary : Talipes Equinovarus, also known as talipes, is related to clubfoot and tarp syndrome. An important gene associated with Talipes Equinovarus is TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4). The drugs Acetylcholine and Cholinergic Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are hearing/vestibular/ear and limbs/digits/tail

Wikipedia : 71 Club foot or clubfoot, is a term for the medical condition congenital talipes equinovarus (CTEV). It is... more...

Related Diseases for Talipes Equinovarus

Graphical network of the top 20 diseases related to Talipes Equinovarus:



Diseases related to Talipes Equinovarus

Symptoms & Phenotypes for Talipes Equinovarus

MGI Mouse Phenotypes related to Talipes Equinovarus:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.33 TRPV4 COL9A1 GLI3
2 limbs/digits/tail MP:0005371 9.13 HOXD13 COL9A1 GLI3
3 vision/eye MP:0005391 8.92 HOXD13 TRPV4 COL9A1 GLI3

Drugs & Therapeutics for Talipes Equinovarus

Drugs for Talipes Equinovarus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 3,Phase 2 51-84-3 187
2 Cholinergic Agents Phase 4,Phase 3,Phase 2
3 Neuromuscular Agents Phase 4,Phase 3,Phase 2
4 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
5 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
6 abobotulinumtoxinA Phase 4,Phase 3,Phase 2
7 incobotulinumtoxinA Phase 4,Phase 3,Phase 2
8 onabotulinumtoxinA Phase 4,Phase 3,Phase 2
9 Botulinum Toxins Phase 4,Phase 3,Phase 2
10 Botulinum Toxins, Type A Phase 4,Phase 3,Phase 2
11 Anesthetics Phase 3
12 Pharmaceutical Solutions Phase 2
13 Hemagglutinins Phase 2
14
Menthol Approved 2216-51-5 16666
15 Neuroserpin
16 Analgesics
17 Astragalus Nutraceutical

Interventional clinical trials:

(show all 40)
id Name Status NCT ID Phase
1 Post Marketing Surveillance Study of Dysport Completed NCT00210431 Phase 4
2 Effects of Botulinum Neurotoxin Type A (BoNT/A) Free of Complexing Proteins in the Spastic Equinovarus Foot Recruiting NCT03044080 Phase 4
3 Efficacy Study of Selective Tibial Neurotomy in the Treatment of the Spastic Equinovarus Foot Among Adult Hemiplegic Patients Completed NCT00825097 Phase 3
4 Study of GSK1358820 In Patients With Post-Stroke Lower Limb Spasticity Completed NCT00460655 Phase 3
5 Treatment With Xeomin Versus Botox in Children With Spastic Equine and Equinovarus Foot Deformation in Pediatric Cerebral Palsy Completed NCT02188277 Phase 2
6 Sucrose Analgesia in Infants Undergoing Casting for Club Foot Unknown status NCT01050088
7 Effectiveness of Parents' Manipulation in Newborn With Talipes Calcaneus Unknown status NCT01767662
8 Genetic Disease Gene Identification Unknown status NCT00916903
9 Safety and Efficacy of the Universal Neonatal Foot Orthosis in the Treatment of Metatarsus Adductus (MTA) Unknown status NCT01600183
10 Clubfoot DNA Repository Completed NCT00607191
11 Exploring the Causes of Clubfoot Using Magnetic Resonance Imaging, MRI Completed NCT01088828
12 Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot) Completed NCT00474344
13 Gait Analysis in Ponseti Clubfoot Completed NCT02022267
14 Polyaxial Brace Fixing for the Treatment of Congenital Clubfoot Completed NCT02815306
15 Outcomes of Compliance With Brace Wear in Clubfoot Completed NCT01481324
16 Comparison of Casting Materials for the Treatment of Clubfoot Using the Ponseti Method Completed NCT01067651
17 A Randomized Controlled Trial of Three Non-pharmacologic Analgesic Techniques for Casting of Clubfoot Infants Completed NCT02395185
18 Treatment of Spastic Equinovarus Foot After Stroke Completed NCT00199589
19 Neuro-orthopaedic Surgery in the Treatment of the Spastic Equinovarus Foot Completed NCT01265238
20 Impairments of Oral Language in Mobius Syndrome Completed NCT00856531
21 Bracing Compliance and Personality Traits: A Compliance Assessment Program for Scoliosis and Clubfeet Recruiting NCT02755766
22 Using Botox to Treat Patients With Idiopathic Clubfoot Recruiting NCT00474032
23 Efficacy Analysis of Minimally Invasive Carroll's Technique in Treatment of Congenital Idiopathic Clubfoot Recruiting NCT02815215 Early Phase 1
24 Pedobarographic Assessments of Clubfoot Treated Patients Recruiting NCT00175708
25 Prospective Evaluation of Treatment for Clubfoot Recruiting NCT02257229
26 Dynamic Evaluation of Ankle Joint and Muscle Mechanics in Children With Spastic Equinus Deformity Due to Cerebral Palsy Recruiting NCT02814786
27 Effectiveness of Manual Manipulation With EPAT on Ankle Dorsiflexion and Dynamic Plantar Pressure Recruiting NCT02233140
28 Trial Readiness and Endpoint Assessment in Congenital Myotonic Dystrophy Recruiting NCT03059264
29 Talonavicular Arthrodesis and Surgical Treatment of Ankle and Varus Foot Recruiting NCT02790346
30 Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer Recruiting NCT01751503
31 Survey Study and Records Review of Treatment Outcomes in Freeman-Sheldon Syndrome Recruiting NCT01144741
32 Duration of Brace Wear in Clubfoot Treatment - A Prospective Randomized Trial Active, not recruiting NCT01551264
33 Efficacy of Botox in Patients With Idiopathic Clubfoot Active, not recruiting NCT00152334
34 A Double-Blind, Randomized Control Trial Comparing Botulinum Toxin Type A (Botox) and Placebo in the Treatment of Idiopathic Clubfoot Active, not recruiting NCT00152347
35 Osteopathic Approach Into Neonatology Ward: the NE-O Model Available NCT01902563
36 Determination of the Pathophysicologic Collagen Changes in the Diabetic Achilles Tendon Suspended NCT01382628
37 Ankle Equinus Contracture Treated With Dynamic Splinting Terminated NCT01238484
38 The Effect of Botulinum Toxin A Injections on Ankle Dorsiflexion Following Internal Fixation of Tibial Pilon Fractures Terminated NCT02051933
39 Economic Evaluation of Clubfoot Treatment: One Centre's Experience Withdrawn NCT00475631
40 Instep Plantar Fasciotomy With and Without Gastrocnemius Recession Withdrawn NCT02287714

Search NIH Clinical Center for Talipes Equinovarus

Genetic Tests for Talipes Equinovarus

Genetic tests related to Talipes Equinovarus:

id Genetic test Affiliating Genes
1 Talipes Equinovarus 29
2 Talipes 29

Anatomical Context for Talipes Equinovarus

MalaCards organs/tissues related to Talipes Equinovarus:

39
Bone

Publications for Talipes Equinovarus

Articles related to Talipes Equinovarus:

(show top 50) (show all 235)
id Title Authors Year
1
The hybrid method for the treatment of congenital talipes equinovarus: preliminary results on 92 consecutive feet. ( 28079742 )
2017
2
Three novel missense mutations in the filamin B gene are associated with isolated congenital talipes equinovarus. ( 27395407 )
2016
3
Fibula extension and correction of foot and ankle deformity to rectify post-osteomyelitis talipes equinovarus in a young adult: a case report and literature review. ( 27383298 )
2016
4
Role of COL9A1 genetic polymorphisms in development of congenital talipes equinovarus in a Chinese population. ( 27819742 )
2016
5
Congenital talipes equinovarus associated with hereditary congenital common peroneal nerve neuropathy: a literature review. ( 26588839 )
2016
6
Birth prevalence of congenital talipes equinovarus in low- and middle-income countries: a systematic review and meta-analysis. ( 28000394 )
2016
7
An Unusual Cause of Talipes Equinovarus: Agenesis of Leg Muscles. ( 27779489 )
2016
8
Treatment of persistent forefoot adduction during ponseti method in treatment of idiopathic talipes equinovarus by minimal soft release. ( 27408483 )
2016
9
A systematic review of association studies of common variants associated with idiopathic congenital talipes equinovarus (ICTEV) in humans in the past 30A years. ( 27386344 )
2016
10
Surgical treatment of neglected congenital idiopathic talipes equinovarus after walking age in Eritrea: an Italo-Eritrean cooperation. ( 26965500 )
2016
11
Congenital idiopathic talipes equinovarus before and after walking age: observations and strategy of treatment from a series of 88 cases. ( 26409466 )
2015
12
Prenatal Ultrasound Diagnosis of Congenital Talipes Equinovarus in Bogota (Colombia) Between 2003 and 2012. ( 26361459 )
2015
13
Prognostic Value of the Radiologic Appearance of the Navicular Ossification Center in Congenital Talipes Equinovarus. ( 26049641 )
2015
14
A rare case of 3C disease: Ritscher-Schinzel syndrome presenting with recurrent talipes equinovarus. ( 25434475 )
2015
15
Interventions for congenital talipes equinovarus (clubfoot). ( 26435670 )
2015
16
Correcting Congenital Talipes Equinovarus in Children Using Three Different Corrective Methods: A Consort Study. ( 26181538 )
2015
17
Comparative results of percutaneous Achilles tenotomy to combined open Achilles tenotomy with posterior capsulotomy in the correction of equinus deformity in congenital talipes equinovarus. ( 25690920 )
2015
18
Open Achilles tenotomy and posterior capsulotomy for congenital talipes equinovarus. ( 26156730 )
2015
19
Patient-Based Long-Term Results of the Surgical Treatment of Congenital Talipes Equinovarus. ( 26634284 )
2015
20
Comment on critical region for talipes equinovarus in patients with 5q23 deletions. ( 25676702 )
2015
21
Talipes equinovarus (clubfoot): neglected for 47 years and subsequent treatment. ( 24859734 )
2014
22
Epithelioid hemangioma of distal femoral epiphysis in a patient with congenital talipes equinovarus. ( 24763238 )
2014
23
Osteopathic manipulative treatment of congenital talipes equinovarus: A case report. ( 24411143 )
2014
24
Does the Ponseti technique affect the vascular development in patients with congenital talipes equinovarus? ( 25229798 )
2014
25
Is congenital talipes equinovarus a risk factor for pathological dysplasia of the hip? : a 21-year prospective, longitudinal observational study. ( 25371473 )
2014
26
Congenital Talipes Equinovarus: Frequency of Associated Malformations not Identified by Prenatal Ultrasound. ( 25394569 )
2014
27
Interventions for congenital talipes equinovarus (clubfoot). ( 25117413 )
2014
28
3D MRI analysis of the lower legs of treated idiopathic congenital talipes equinovarus (clubfoot). ( 23382871 )
2013
29
Fertile eunuch syndrome in association with biventricular noncompaction, bicuspid aortic valve, severe aortic stenosis, and talipes equinovarus. ( 23678225 )
2013
30
Consanguineous marriage and increased risk of idiopathic congenital talipes equinovarus: a case-control study in a rural area. ( 23482273 )
2013
31
Congenital idiopathic talipes equinovarus: an evaluation in infants treated by the Ponseti method. ( 24142617 )
2013
32
SOX9 overexpression plays a potential role in idiopathic congenital talipes equinovarus. ( 23254326 )
2013
33
Copy number analysis of 413 isolated talipes equinovarus patients suggests role for transcriptional regulators of early limb development. ( 22892537 )
2013
34
Outpatient taping in the treatment of idiopathic congenital talipes equinovarus. ( 23365041 )
2013
35
The inter-relationship of clinical parameters in congenital talipes equinovarus: relevance to pathological anatomy and clinical classification. ( 23450265 )
2012
36
Correlation of foot bimalleolar angle with Pirani score to assess the severity of congenital talipes equinovarus deformity. ( 21912337 )
2012
37
Assessment of calf volume in Congenital Talipes Equinovarus by computer analysed digital photography. ( 22385530 )
2012
38
[Possible role of GLI3 gene in the pathogenesis of idiopathic congenital talipes equinovarus]. ( 22678783 )
2012
39
Congenital talipes equinovarus: an epidemiological study in Sicily. ( 22489891 )
2012
40
Value of the fetal plantar shape in prenatal diagnosis of talipes equinovarus. ( 22733848 )
2012
41
A single-center prospective evaluation of the Ponseti method in nonidiopathic congenital talipes equinovarus. ( 22892629 )
2012
42
Assessment of talipes equinovarus treated by Ponseti technique: three-year preliminary report. ( 22387138 )
2012
43
Prenatal detection and postnatal outcome of congenital talipes equinovarus in 106 fetuses. ( 22580510 )
2012
44
Interventions for congenital talipes equinovarus (clubfoot). ( 22513960 )
2012
45
Paralytic congenital talipes equinovarus of unknown origin: A new entity. Multicenter study of 42A cases. ( 22818425 )
2012
46
Parental consanguinity and associated factors in congenital talipes equinovarus. ( 21920728 )
2012
47
[Expression of COL9A1 gene and its polymorphism in children with idiopathic congenital talipes equinovarus]. ( 21672422 )
2011
48
Talipes equinovarus as leading symptom of congenital myotonic dystrophy type 2. ( 21462219 )
2011
49
Simultaneous correction of congenital vertical talus and talipes equinovarus using the Ponseti method. ( 20797881 )
2011
50
Management of congenital talipes equinovarus using the Ponseti method: a systematic review. ( 21911524 )
2011

Variations for Talipes Equinovarus

ClinVar genetic disease variations for Talipes Equinovarus:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 PITX1 NM_002653.4(PITX1): c.388G> A (p.Glu130Lys) single nucleotide variant Pathogenic rs121909109 GRCh37 Chromosome 5, 134366980: 134366980
2 RYR1 NM_000540.2(RYR1): c.7268T> A (p.Met2423Lys) single nucleotide variant Pathogenic rs118192174 GRCh37 Chromosome 19, 38990601: 38990601
3 TRPV4 NM_021625.4(TRPV4): c.947G> A (p.Arg316His) single nucleotide variant Pathogenic rs387906905 GRCh37 Chromosome 12, 110236624: 110236624
4 PITX1 NM_002653.4(PITX1): c.765_799del35 (p.Ala256Argfs) deletion Pathogenic rs730882191 GRCh38 Chromosome 5, 135028925: 135028959

Expression for Talipes Equinovarus

Search GEO for disease gene expression data for Talipes Equinovarus.

Pathways for Talipes Equinovarus

GO Terms for Talipes Equinovarus

Biological processes related to Talipes Equinovarus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 anterior/posterior pattern specification GO:0009952 9.32 GLI3 HOXD13
2 embryonic digit morphogenesis GO:0042733 9.26 GLI3 HOXD13
3 embryonic limb morphogenesis GO:0030326 9.16 GLI3 HOXD13
4 pattern specification process GO:0007389 8.96 GLI3 HOXD13
5 limb morphogenesis GO:0035108 8.62 GLI3 HOXD13

Sources for Talipes Equinovarus

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