Aliases & Classifications for Talipes Equinovarus

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Aliases & Descriptions for Talipes Equinovarus:

Name: Talipes Equinovarus 46 25
Talipes 46 25
Congenital Talipes Equinovarus 46
 
Clubfoot 46
Ctev 46

Classifications:



External Ids:

ICD1028 Q66.0

Summaries for Talipes Equinovarus

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NIH Rare Diseases:46 Talipes equinovarus is a congenital (present from birth) condition where the foot turns inward and downward. the cause of this condition is not known, although it may be passed down through families in some cases. this condition occurs in about 1 out of every 1,000 births. treatment may involve moving the foot into the correct position and using a cast to keep it there. this process is done in small increments over a period of time. in severe cases, surgery may be needed.  <span style="font-size: 16px;"> &lt;span style="font-size: 13px;"&gt; body {background-color: #ffffff; font-family: "times new roman"; font-size: 12pt;} &lt;/span&gt; </span> ]]> last updated: 2/27/2014

MalaCards based summary: Talipes Equinovarus, also known as talipes, is related to clubfoot and intellectual deficit unusual facies talipes hand anomalies. An important gene associated with Talipes Equinovarus is GLI3 (GLI Family Zinc Finger 3). Affiliated tissues include bone, and related mouse phenotypes are hearing/vestibular/ear and skeleton.

Wikipedia:69 Club foot or clubfoot, also called Congenital Talipes Equinovarus (CTEV), is a congenital deformity... more...

Related Diseases for Talipes Equinovarus

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Graphical network of the top 20 diseases related to Talipes Equinovarus:



Diseases related to talipes equinovarus

Symptoms for Talipes Equinovarus

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Drugs & Therapeutics for Talipes Equinovarus

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Drugs for Talipes Equinovarus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AcetylcholinePhase 4, Phase 3, Phase 275251-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
2
Menthol21842216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol

Interventional clinical trials:

(show all 37)
idNameStatusNCT IDPhase
1Post Marketing Surveillance Study of DysportCompletedNCT00210431Phase 4
2Efficacy Study of Selective Tibial Neurotomy in the Treatment of the Spastic Equinovarus Foot Among Adult Hemiplegic PatientsCompletedNCT00825097Phase 3
3Study of GSK1358820 In Patients With Post-Stroke Lower Limb SpasticityCompletedNCT00460655Phase 3
4Treatment With Xeomin Versus Botox in Children With Spastic Equine and Equinovarus Foot Deformation in Pediatric Cerebral PalsyRecruitingNCT02188277Phase 2
5Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot)CompletedNCT00474344
6Exploring the Causes of Clubfoot Using Magnetic Resonance Imaging, MRICompletedNCT01088828
7Comparison of Casting Materials for the Treatment of Clubfoot Using the Ponseti MethodCompletedNCT01067651
8Gait Analysis in Ponseti ClubfootCompletedNCT02022267
9Polyaxial Brace Fixing for the Treatment of Congenital ClubfootCompletedNCT02815306
10Outcomes of Compliance With Brace Wear in ClubfootCompletedNCT01481324
11A Randomized Controlled Trial of Three Non-pharmacologic Analgesic Techniques for Casting of Clubfoot InfantsCompletedNCT02395185
12Treatment of Spastic Equinovarus Foot After StrokeCompletedNCT00199589
13Neuro-orthopaedic Surgery in the Treatment of the Spastic Equinovarus FootCompletedNCT01265238
14Impairments of Oral Language in Mobius SyndromeCompletedNCT00856531
15Clubfoot DNA RepositoryRecruitingNCT00607191
16Bracing Compliance and Personality Traits: A Compliance Assessment Program for Scoliosis and ClubfeetRecruitingNCT02755766
17Using Botox to Treat Patients With Idiopathic ClubfootRecruitingNCT00474032
18Pedobarographic Assessments of Clubfoot Treated PatientsRecruitingNCT00175708
19Efficacy Analysis of Minimally Invasive Carroll's Technique in Treatment of Congenital Idiopathic ClubfootRecruitingNCT02815215Phase 0
20Prospective Evaluation of Treatment for ClubfootRecruitingNCT02257229
21Effectiveness of Parents' Manipulation in Newborn With Talipes CalcaneusRecruitingNCT01767662
22Effectiveness of Manual Manipulation With EPAT on Ankle Dorsiflexion and Dynamic Plantar PressureRecruitingNCT02233140
23Talonavicular Arthrodesis and Surgical Treatment of Ankle and Varus FootRecruitingNCT02790346
24Extramembranous and Interosseous Technique of Tibialis Posterior Tendon TransferRecruitingNCT01751503
25Duration of Brace Wear in Clubfoot Treatment - A Prospective Randomized TrialActive, not recruitingNCT01551264
26Efficacy of Botox in Patients With Idiopathic ClubfootActive, not recruitingNCT00152334
27A Double-Blind, Randomized Control Trial Comparing Botulinum Toxin Type A (Botox) and Placebo in the Treatment of Idiopathic ClubfootActive, not recruitingNCT00152347
28Osteopathic Approach Into Neonatology Ward: the NE-O ModelAvailableNCT01902563
29Genetic Disease Gene IdentificationEnrolling by invitationNCT00916903
30Sucrose Analgesia in Infants Undergoing Casting for Club FootNot yet recruitingNCT01050088
31Dynamic Evaluation of Ankle Joint and Muscle Mechanics in Children With Spastic Equinus Deformity Due to Cerebral PalsyNot yet recruitingNCT02814786
32Safety and Efficacy of the Universal Neonatal Foot Orthosis in the Treatment of Metatarsus Adductus (MTA)Not yet recruitingNCT01600183
33Determination of the Pathophysicologic Collagen Changes in the Diabetic Achilles TendonSuspendedNCT01382628
34Ankle Equinus Contracture Treated With Dynamic SplintingTerminatedNCT01238484
35The Effect of Botulinum Toxin A Injections on Ankle Dorsiflexion Following Internal Fixation of Tibial Pilon FracturesTerminatedNCT02051933
36Economic Evaluation of Clubfoot Treatment: One Centre's ExperienceWithdrawnNCT00475631
37Instep Plantar Fasciotomy With and Without Gastrocnemius RecessionWithdrawnNCT02287714

Search NIH Clinical Center for Talipes Equinovarus

Genetic Tests for Talipes Equinovarus

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Genetic tests related to Talipes Equinovarus:

id Genetic test Affiliating Genes
1 Talipes Equinovarus25
2 Talipes25

Anatomical Context for Talipes Equinovarus

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MalaCards organs/tissues related to Talipes Equinovarus:

34
Bone

Animal Models for Talipes Equinovarus or affiliated genes

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MGI Mouse Phenotypes related to Talipes Equinovarus:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.9COL9A1, GLI3, IRF6
2MP:00053908.1COL9A1, GLI3, HOXD13, IRF6
3MP:00053717.8COL9A1, GLI3, HOXD13, IRF6

Publications for Talipes Equinovarus

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Articles related to Talipes Equinovarus:

(show top 50)    (show all 231)
idTitleAuthorsYear
1
Surgical treatment of neglected congenital idiopathic talipes equinovarus after walking age in Eritrea: an Italo-Eritrean cooperation. (26965500)
2016
2
Three novel missense mutations in the filamin B gene are associated with isolated congenital talipes equinovarus. (27395407)
2016
3
Open Achilles tenotomy and posterior capsulotomy for congenital talipes equinovarus. (26156730)
2015
4
Comment on critical region for talipes equinovarus in patients with 5q23 deletions. (25676702)
2015
5
Interventions for congenital talipes equinovarus (clubfoot). (25117413)
2014
6
Does the Ponseti technique affect the vascular development in patients with congenital talipes equinovarus? (25229798)
2014
7
Talipes equinovarus (clubfoot): neglected for 47 years and subsequent treatment. (24859734)
2014
8
Copy number analysis of 413 isolated talipes equinovarus patients suggests role for transcriptional regulators of early limb development. (22892537)
2013
9
SOX9 overexpression plays a potential role in idiopathic congenital talipes equinovarus. (23254326)
2013
10
The inter-relationship of clinical parameters in congenital talipes equinovarus: relevance to pathological anatomy and clinical classification. (23450265)
2012
11
Management of congenital talipes equinovarus using the Ponseti method: a systematic review. (21911524)
2011
12
The effect of neuromuscular electrical stimulation on congenital talipes equinovarus following correction with the Ponseti method: a pilot study. (20581693)
2010
13
Congenital talipes equinovarus associated with myotonic dystrophy type 2. (20665517)
2010
14
Epidemiology of congenital idiopathic talipes equinovarus in Iowa, 1997-2005. (20583169)
2010
15
Application of Ponseti method in patients older than 6 months with congenital talipes equinovarus. (19727237)
2009
16
Variation in WNT7A is unlikely to be a cause of familial congenital talipes equinovarus. (18538017)
2008
17
Apoptotic gene analysis in idiopathic talipes equinovarus (clubfoot). (17534194)
2007
18
The Ponseti technique for treatment of talipes equinovarus. (16598912)
2006
19
The management of congenital talipes equinovarus. (16263225)
2005
20
Talipes equinovarus in Western Australia. (12675786)
2003
21
Congenital talipes equinovarus (clubfoot): a disorder of the foot but not the hand. (12587918)
2003
22
Three-dimensional ultrasound in prenatal counselling of congenital talipes equinovarus. (12399101)
2002
23
Talipes equinovarus and maternal smoking: a population-based case-control study in Washington state. (12210013)
2002
24
Peritalar release in the treatment of congenital talipes equinovarus clubfoot. (12056243)
2001
25
Evaluation of foot bimalleolar angle in the management of congenital talipes equinovarus. (11176354)
2001
26
The functional outcome of staged surgery for the correction of talipes equinovarus. (10912611)
2000
27
Somatosensory evoked potentials as a means of assessing neurological abnormality in congenital talipes equinovarus. (10981930)
2000
28
Functional results of surgical treatment in congenital talipes equinovarus (clubfoot): a comparison of outcome measurements. (11143473)
2000
29
MRI multiplanar reconstruction in the assessment of congenital talipes equinovarus. (10199904)
1999
30
Congenital talipes equinovarus in spina bifida: treatment and results. (8906652)
1996
31
Relationship between acquired spastic talipes equinovarus and dystonia musculorum deformans. (8416347)
1993
32
Tibial torsion measured by ultrasound in children with talipes equinovarus. (2005140)
1991
33
Assessment in congenital talipes equinovarus. (2210529)
1990
34
Congenital talipes equinovarus. (2391207)
1990
35
Results of surgical treatment of talipes equinovarus congenita. (2805484)
1989
36
Posteromedial release for idiopathic talipes equinovarus. A long-term follow-up study. (2706856)
1989
37
Anatomy of uncorrected talipes equinovarus in a fifteenth-century American Indian. (2674408)
1989
38
A brace for the radiological evaluation of talipes equinovarus. (2825881)
1987
39
Talipes equinovarus: two case reports and literature review. (3316360)
1987
40
A higher incidence of congenital structural talipes equinovarus in gypsies. (6840781)
1983
41
Talipes equinovarus. (6554645)
1983
42
HLA and clubfoot (idiopathic talipes equinovarus). (7071822)
1982
43
Early Dwyer operation in talipes equinovarus. (7471561)
1981
44
Surgical correction of resistant talipes equinovarus: observations and analysis - preliminary report. (7341386)
1981
45
Analytical radiography and the progressive approach in talipes equinovarus. (643260)
1978
46
Talipes equinovarus: &quot;hard&quot; versus &quot;soft&quot; tissues. (856511)
1977
47
THE GENETICS OF TALIPES EQUINOVARUS. (14133340)
1964
48
Congenital talipes equinovarus. (13896777)
1961
49
Recurring congenital talipes equinovarus. (13806063)
1960
50
The conservative treatment of congenital talipes equinovarus. (21003186)
1946

Variations for Talipes Equinovarus

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Expression for genes affiliated with Talipes Equinovarus

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Search GEO for disease gene expression data for Talipes Equinovarus.

Pathways for genes affiliated with Talipes Equinovarus

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GO Terms for genes affiliated with Talipes Equinovarus

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Biological processes related to Talipes Equinovarus according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1limb morphogenesisGO:00351089.9GLI3, HOXD13
2embryonic digit morphogenesisGO:00427339.8GLI3, HOXD13
3regulation of apoptotic processGO:00429819.8GLI3, RBM10
4anterior/posterior pattern specificationGO:00099529.7GLI3, HOXD13
5pattern specification processGO:00073899.5GLI3, HOXD13
6regulation of cell proliferationGO:00421279.5GLI3, HOXD13
7embryonic limb morphogenesisGO:00303269.1GLI3, HOXD13
8negative regulation of cell proliferationGO:00082858.7GLI3, IRF6, RBM10

Molecular functions related to Talipes Equinovarus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription factor activity, sequence-specific DNA bindingGO:00037008.6GLI3, HOXD13, IRF6

Sources for Talipes Equinovarus

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet