CTEV
MCID: TLP001
MIFTS: 49

Talipes Equinovarus (CTEV) malady

Summaries for Talipes Equinovarus

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64Wikipedia, 33MalaCards
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Wikipedia:64 A club foot or clubfoot, also called congenital talipes equinovarus (CTEV), is a congenital deformity... more...

MalaCards: Talipes Equinovarus, also known as congenital talipes equinovarus, is related to clubfoot and cleft palate. An important gene associated with Talipes Equinovarus is HOXD13 (homeobox D13), and among its related pathways are Regulation by c-FLIP and FasL/ CD95L signaling. The compounds n-hydroxyarylamine and nitroarenes have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, and related mouse phenotypes are hearing/vestibular/ear and renal/urinary system.

Aliases & Classifications for Talipes Equinovarus

Sources:
43NIH Rare Diseases, 22GTR, 25ICD10
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Classifications:



Aliases & Descriptions:

talipes equinovarus 43 22
congenital talipes equinovarus 43
clubfoot 43
talipes 43
ctev 43


External Ids:

ICD1025 Q66.0

Related Diseases for Talipes Equinovarus

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Talipes Equinovarus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 235)
idRelated DiseaseScoreTop Affiliating Genes
1clubfoot31.1COL9A1, HOXD10, SLC26A2, HOXD13, GLI3, PITX1
2cleft palate30.0NAT1
3osteoarthritis29.8COL1A1, COL9A1
4syndactyly29.7HOXD13, GLI3, HOXD12
5tarp syndrome10.5
6congenital myotonic dystrophy10.4
7clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly10.3
8myelomeningocele10.3
9adducted thumb and clubfoot syndrome10.3
10ehlers–danlos syndrome10.2
11short stature robin sequence cleft mandible hand anomalies clubfoot10.2
12familial clubfoot due to 17q23.1q23.2 microduplication10.2
13n syndrome10.2
14aortic valve stenosis10.2
15spina bifida10.2
16kabuki syndrome10.2
17corpus callosum agenesis10.2
18camptodactyly joint contractures and facial skeletal dysplasia10.2
19crane-heise syndrome10.2
20vertical talus, congenital10.2
21fertile eunuch syndrome10.2
22frontonasal dysplasia acromelic10.2
23infantile scoliosis10.2
24metatarsus adductus10.2
25pseudohypoaldosteronism type ii10.1
26richieri costa pereira syndrome10.1
27familial clubfoot due to 5q31 microdeletion10.1
28intellectual deficit unusual facies talipes hand anomalies10.1
29esophageal atresia coloboma talipes10.1
30short stature talipes natal teeth10.1
31xeroderma talipes enamel defects10.1
32spondyloepiphyseal dysplasia with congenital joint dislocations10.0
33atelosteogenesis type 210.0
34moebius syndrome10.0
35arthrogryposis multiplex congenita distal type 110.0
36ehlers-danlos syndrome, musculocontractural type10.0
37pitx1-related congenital clubfoot10.0
38ehlers-danlos syndrome, musculocontractural type 210.0
39brachydactyly-syndactyly syndrome10.0HOXD13
40laryngeal squamous cell carcinoma10.0NAT2
41brachydactyly10.0HOXD13
42malignant mesothelioma10.0NAT2
43herpes simplex10.0COL1A1
44polydactyly10.0GLI3, HOXD12, HOXD13
45myocardial infarction10.0CFH
46acute leukemia10.0APAF1, CASP8
47retinal drusen10.0CFH
48pseudoachondroplasia10.0COL9A1, SLC26A2
49myopathy10.0FHL1
50hepatitis10.0NAT2, CASP8

Graphical network of the top 20 diseases related to Talipes Equinovarus:



Diseases related to talipes equinovarus

Clinical Features for Talipes Equinovarus

Drugs & Therapeutics for Talipes Equinovarus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Talipes Equinovarus

Search CenterWatch for Talipes Equinovarus

Genetic Tests for Talipes Equinovarus

Sources:
22GTR
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Genetic tests related to Talipes Equinovarus:

id Genetic test Affiliating Genes
1 Talipes Equinovarus22

Anatomical Context for Talipes Equinovarus

Sources:
33MalaCards
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MalaCards organs/tissues related to Talipes Equinovarus:

33
Skeletal muscle

Animal Models for Talipes Equinovarus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Talipes Equinovarus:

37 (show all 17)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.5COL9A1, APAF1, PITX1, GLI3, WNT7A
2MP:00053679.4HOXD13, HOXD10, CFH
3MP:00053919.1COL9A1, FHL1, HOXD13, WNT7A, BID
4MP:00053808.7COL1A1, CASP9, PITX1, GLI3, HOXD12, WNT7A
5MP:00053698.6CASP3, CASP8, PITX1, HOXD13, HOXD10, HOXD12
6MP:00053798.4CASP3, CASP8, APAF1, HOXD13, BID
7MP:00053828.4COL1A1, CASP3, CASP9, APAF1, PITX1, GLI3
8MP:00053718.1SLC26A2, COL9A1, COL1A1, APAF1, PITX1, GLI3
9MP:00053818.0COL1A1, CASP3, APAF1, PITX1, GLI3, HOXD13
10MP:00053887.9CASP3, CASP8, CASP9, APAF1, GLI3, BID
11MP:00053897.9COL1A1, CASP3, GLI3, HOXD13, HOXD12, NAT1
12MP:00053907.9PITX1, APAF1, CASP3, COL9A1, GLI3, HOXD13
13MP:00036317.1COL1A1, CASP3, CASP8, CASP9, FHL1, APAF1
14MP:00053847.1CASP3, CASP8, CASP9, APAF1, GLI3, HOXD10
15MP:00053856.6COL1A1, CASP3, CASP8, CASP9, FHL1, APAF1
16MP:00053766.5COL9A1, COL1A1, CASP3, CASP8, FHL1, GLI3
17MP:00107685.6COL1A1, CASP3, CASP8, CASP9, APAF1, PITX1

Publications for Talipes Equinovarus

Sources:
51PubMed
See all sources

Articles related to Talipes Equinovarus:

(show top 50)    (show all 209)
idTitleAuthorsYear
1
Osteopathic manipulative treatment of congenital talipes equinovarus: A case report. (24411143)
2014
2
Fertile eunuch syndrome in association with biventricular noncompaction, bicuspid aortic valve, severe aortic stenosis, and talipes equinovarus. (23678225)
2013
3
Possible role of GLI3 gene in the pathogenesis of idiopathic congenital talipes equinovarus]. (22678783)
2012
4
Paralytic congenital talipes equinovarus of unknown origin: A new entity. Multicenter study of 42A cases. (22818425)
2012
5
Value of the fetal plantar shape in prenatal diagnosis of talipes equinovarus. (22733848)
2012
6
Management of congenital talipes equinovarus using the Ponseti method: a systematic review. (21911524)
2011
7
Expression of COL9A1 gene and its polymorphism in children with idiopathic congenital talipes equinovarus]. (21672422)
2011
8
Is there evidence for aetiologically distinct subgroups of idiopathic congenital talipes equinovarus? A case-only study and pedigree analysis. (21533128)
2011
9
Current management of clubfoot (congenital talipes equinovarus). (20124368)
2010
10
Apoptotic gene analysis in idiopathic talipes equinovarus (clubfoot). (17534194)
2007
11
Histologic and histochemical analysis of muscle specimens in idiopathic talipes equinovarus. (16439910)
2006
12
Early results of a physiotherapist-delivered Ponseti service for the management of idiopathic congenital talipes equinovarus foot deformity. (16877611)
2006
13
Lack of seasonal variation in idiopathic talipes equinovarus. (16510813)
2006
14
Radiographic assessment of congenital talipes equinovarus: strapping versus forced dorsiflexion. (16914799)
2006
15
Risk factors for isolated talipes equinovarus in Western Australia, 1980-1994. (15860082)
2005
16
Intrauterine structure of foot muscles in talipes equinovarus due to high-level myelomeningocele: a light microscopic study in fetal cadavers. (15199283)
2004
17
Congenital idiopathic talipes equinovarus. (15060180)
2004
18
Three-dimensional ultrasound in prenatal counselling of congenital talipes equinovarus. (12399101)
2002
19
Talipes equinovarus and maternal smoking: a population-based case-control study in Washington state. (12210013)
2002
20
Prenatal ultrasonographic diagnosis of talipes equinovarus: does it give the full picture? (12230440)
2002
21
Idiopathic congenital talipes equinovarus. (15089073)
2002
22
Seasonal distribution of idiopathic congenital talipes equinovarus in Scotland. (11943986)
2002
23
DTDST mutations are not a frequent cause of idiopathic talipes equinovarus (club foot). (11950872)
2002
24
7 Talipes equinovarus (club foot) - a developmental disorder of the foot and not the hand. (17103750)
2002
25
The classification of congenital talipes equinovarus. (12358365)
2002
26
Evaluation of foot bimalleolar angle in the management of congenital talipes equinovarus. (11176354)
2001
27
Relapse in staged surgery for congenital talipes equinovarus. (11284589)
2001
28
The functional outcome of staged surgery for the correction of talipes equinovarus. (10912611)
2000
29
Relapse in staged surgery for congenital talipes equinovarus. (10963177)
2000
30
Genetic epidemiology study of idiopathic talipes equinovarus. (9741465)
1998
31
Segregation analysis of idiopathic talipes equinovarus in a Texan population. (9741466)
1998
32
Surgical correction of talipes equinovarus following foot and leg compartment syndrome. (8791080)
1996
33
Bilateral 'Jones' fractures of the fifth metatarsal following relapse of talipes equinovarus. (8994571)
1996
34
Intraoperative ultrasound for evaluation of reduction in congenital talipes equinovarus. (7719835)
1995
35
Ultrasound: a helpful guide in the treatment of congenital talipes equinovarus. (7719837)
1995
36
Risk indicators for talipes equinovarus in Washington State, 1987-1989. (1912045)
1991
37
Congenital talipes equinovarus: II. A staged method of surgical management. (3680352)
1987
38
The management of congenital talipes equinovarus in developing countries. (3623753)
1987
39
A supernumerary microchromosome in amniotic cell cultures and talipes equinovarus in a live born female. (6499260)
1984
40
The results of pantalar reduction in the management of congenital talipes equinovarus. (6822594)
1983
41
Aetiology and interrelationship of some common skeletal deformities. (Talipes equinovarus and calcaneovalgus, metatarsus varus, congenital dislocation of the hip, and infantile idiopathic scoliosis). (7143383)
1982
42
Gillette Children's Hospital experience with the Turco procedure for clubfeet (talipes Equinovarus). (7335046)
1981
43
Talipes equinovarus associated with an absent posterior tibial tendon and a tarsal coalition: a case report. (7371259)
1980
44
Severe congenital talipes equinovarus. (5909063)
1966
45
THE GENETICS OF TALIPES EQUINOVARUS. (14133340)
1964
46
Open correction of recurrent talipes equinovarus. A study of end-results. (13952442)
1963
47
Congenital talipes equinovarus. (13896777)
1961
48
A three-year survey of treatment of congenital talipes equinovarus at Detroit Osteopathic Hospital. (13428597)
1957
49
Pathological anatomy in talipes equinovarus. (13022712)
1953
50
The conservative treatment of congenital talipes equinovarus. (21003186)
1946

Genetic Variations for Talipes Equinovarus

Expression for genes affiliated with Talipes Equinovarus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Talipes Equinovarus

Search GEO for disease gene expression data for Talipes Equinovarus.

Pathways for genes affiliated with Talipes Equinovarus

Sources:
54Reactome, 50PharmGKB, 30KEGG, 38NCBI BioSystems Database, 56SinoBiological, 12EMD Millipore, 52QIAGEN, 60Tocris Bioscience, 53R&D Systems, 4Cell Signaling Technology
See all sources

Pathways related to Talipes Equinovarus according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.9CASP8, CASP10
2
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9.9CASP8, CASP10
39.9NAT2, NAT1
4
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9.9NAT1, NAT2
59.9NAT1, NAT2
69.5CASP9, CASP3
79.3CASP10, CASP3, CASP9
89.3CASP8, BID
9
Apoptosis and survival Lymphotoxin-beta receptor signaling
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9.3CASP3, APAF1, CASP9
10
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9.3CASP3, APAF1, CASP9
11
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9.3APAF1, CASP9, CASP3
129.3APAF1, CASP3, CASP9
139.3APAF1, CASP3, CASP9
149.3APAF1, CASP9, CASP3
15
Hide members
9.2CASP8, CASP3, CASP9
169.2CASP3, CASP8, CASP9
17
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9.0CASP3, CASP8, CASP10, CASP9
18
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9.0CASP10, CASP9, CASP8, CASP3
19
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9.0CASP10, CASP9, CASP8, CASP3
20
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9.0CASP9, CASP3, CASP10, CASP8
21
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9.0CASP8, CASP9, CASP10, CASP3
229.0CASP3, CASP8, CASP10, CASP9
238.9CASP8, CASP3, CASP9, APAF1
24
Hide members
8.9CASP9, CASP8, APAF1, CASP3
258.7CASP10, CASP3, WNT7A, CASP9, CASP8
26
Hide members
8.7CASP9, APAF1, CASP8, CASP3, CASP10
27
Hide members
8.7CASP10, CASP3, CASP8, APAF1, CASP9
288.6APAF1, CASP9, CASP8, BID
29
Hide members
8.6CASP3, CASP8, BID, CASP10
30
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8.5BID, CASP9, CASP3, CASP10
31
Hide members
8.4CASP3, CASP9, APAF1, BID
328.4CASP9, CASP8, CASP3, BID
338.4CASP3, CASP9, BID, CASP8
34
Hide members
8.1BID, APAF1, CASP3, CASP8, CASP9
35
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8.1CASP3, CASP8, CASP9, APAF1, BID
368.1CASP3, CASP8, CASP9, APAF1, BID
37
Hide members
8.1CASP3, BID, APAF1, CASP9, CASP8
38
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8.1APAF1, CASP3, CASP8, CASP9, BID
397.9CASP8, CASP3, WNT7A, CASP9, GLI3, BID
40
Hide members
7.9CASP10, APAF1, BID, CASP9, CASP8, CASP3
41
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7.9CASP9, APAF1, CASP8, CASP10, BID, CASP3
42
Apoptosis and survival Caspase cascade
Hide members
7.9BID, APAF1, CASP9, CASP8, CASP10, CASP3
43
Hide members
7.9CASP10, CASP8, CASP3, APAF1, BID, CASP9
44
Apoptosis and survival Apoptotic TNF-family pathways
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7.9CASP10, CASP3, CASP8, CASP9, APAF1, BID
457.9CASP3, CASP10, CASP9, APAF1, BID, CASP8
467.9BID, CASP10, CASP3, CASP8, APAF1, CASP9
47
Hide members
7.9APAF1, CASP3, CASP9, CASP10, CASP8, BID
487.9BID, CASP10, CASP3, CASP8, CASP9, APAF1
49
Hide members
7.9APAF1, CASP10, BID, CASP3, CASP9, CASP8
50
Hide members
7.3APAF1, BID, COL9A1, CASP9, CASP8, COL1A1

Compounds for genes affiliated with Talipes Equinovarus

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 2BitterDB
See all sources

Compounds related to Talipes Equinovarus according to GeneCards/GeneDecks:

(show top 50)    (show all 99)
idCompoundScoreTop Affiliating Genes
1n-hydroxyarylamine4510.1NAT1, NAT2
2nitroarenes4510.1NAT1, NAT2
3n-hydroxy-2-aminofluorene4510.1NAT2, NAT1
4paraphenylenediamine4510.1NAT1, NAT2
5codeinone459.9CASP8, CASP9
6dioscin29 4510.9CASP8, CASP9
7diosgenin459.8CASP9, CASP8
8tpen459.8CASP8, CASP3
9d-api459.6CASP3, CASP8, CASP9
10bongkrekic acid459.6CASP9, CASP8, CASP3
11shikonin459.6CASP9, CASP3, CASP8
127-ketocholesterol45 2410.6CASP9, CASP3, CASP8
13betulinic acid45 2910.6CASP3, CASP9, CASP8
14rhodamine 12345 5010.5CASP9, CASP8, CASP3
15vitamin e succinate459.5CASP8, CASP9, CASP3
162-chlorodeoxyadenosine459.5APAF1, CASP9, CASP8
17sulindac sulfide459.5CASP8, CASP9, CASP3
18z-devd-fmk60 2910.4CASP9, CASP8, CASP3, CASP10
19z-dqmd-fmk60 2910.4CASP10, CASP3, CASP8, CASP9
20az 10417808609.4CASP10, CASP3, CASP8, CASP9
21z-vad-fmk45 6010.4CASP9, CASP8, CASP3, CASP10
22celecoxib45 60 29 50 11 2414.3CASP8, CASP9, APAF1, CASP3
23lactacystin459.2APAF1, CASP9, CASP8, CASP3
24triptolide459.2CASP3, CASP8, CASP9
25calpeptin45 6010.0CASP9, CASP3, BID
26dexamethasone45 50 29 1111.9SLC26A2, CFH, NAT2, APAF1, CASP8, COL1A1
27cardiolipin45 119.9CASP9, CASP8, BID, CFH
28simvastatin45 50 60 29 11 2413.8COL1A1, CASP9, CASP3, CASP8
294,6-diamidino-2-phenylindole458.8CASP3, BID, CASP9, CASP8
30sanguinarine458.8CASP9, CASP8, CASP3, BID
31phenethyl isothiocyanate45 29.8BID, CASP8, CASP3, CASP9
32cd 437458.8BID, CASP3, CASP8, CASP9
33parthenolide45 29.8CASP3, CASP8, BID, CASP9
34suberoylanilide hydroxamic acid458.8CASP8, CASP9, BID, CASP3
35flavopiridol45 119.8BID, CASP9, CASP8, CASP3
36gemcitabine45 50 1110.7CASP8, CASP3, CASP9, BID
37sp 60012545 609.7CASP3, CASP8, CASP9, BID
38noxa458.5CASP8, CASP9, APAF1, CASP3, BID
39bortezomib45 119.5BID, APAF1, CASP9, CASP8, CASP3
40adpribose458.5BID, APAF1, CASP9, CASP8, CASP3
41camptothecin45 60 1110.5APAF1, CASP9, CASP3, CASP8, BID
42phosphatidylserine45 29 1110.5CASP8, BID, APAF1, CASP9, CASP3
43curcumin458.5CASP3, BID, CASP8, CASP9, NAT1
44docetaxel45 50 60 1111.5CASP3, CASP8, CASP9, NAT2, BID
45etoposide45 50 60 1111.4CASP3, APAF1, CASP9, CASP8, BID
46mg 13245 609.3CASP3, CASP8, BID, CASP9
47paclitaxel45 50 1110.0NAT1, BID, CASP9, CASP3, CASP10, APAF1
48cisplatin45 50 60 1110.8CASP8, CFH, BID, APAF1, CASP9, CASP3
49doxorubicin45 50 119.8CASP3, BID, CASP8, CASP9, APAF1
50cysteine456.7CASP3, COL1A1, CASP10, CASP8, CASP9, APAF1

GO Terms for genes affiliated with Talipes Equinovarus

Sources:
16Gene Ontology
See all sources

Cellular components related to Talipes Equinovarus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptosomeGO:0432939.8APAF1, CASP9
2cytosolGO:0058296.5BID, CASP10, CASP3, CASP8, CASP9, FHL1

Biological processes related to Talipes Equinovarus according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1anterior/posterior pattern specificationGO:0099529.6GLI3, HOXD13, HOXD10
2activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cGO:0086359.4APAF1, CASP3, CASP9
3apoptotic signaling pathwayGO:0971909.4CASP8, CASP10, CASP3
4embryonic digit morphogenesisGO:0427339.3HOXD12, WNT7A, GLI3, HOXD13
5skeletal system developmentGO:0015019.2HOXD12, HOXD13, PITX1, COL1A1
6neuron apoptotic processGO:0514029.0CASP3, APAF1, BID
7regulation of apoptotic processGO:0429818.9CASP9, CASP10, APAF1, CASP3
8intrinsic apoptotic signaling pathwayGO:0971938.3CASP3, CASP8, CASP9, APAF1, BID
9apoptotic processGO:0069157.9BID, CASP10, CASP3, APAF1, CASP9, CASP8

Molecular functions related to Talipes Equinovarus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1arylamine N-acetyltransferase activityGO:0040609.6NAT2, NAT1
2sequence-specific DNA bindingGO:0435659.0HOXD12, HOXD10, HOXD13, GLI3, PITX1
3cysteine-type endopeptidase activityGO:0041978.9CASP10, CASP9, CASP8, CASP3

Products for genes affiliated with Talipes Equinovarus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Talipes Equinovarus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet