MCID: TLP001
MIFTS: 32

Talipes Equinovarus malady

Category: Rare diseases

Aliases & Classifications for Talipes Equinovarus

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Aliases & Descriptions for Talipes Equinovarus:

Name: Talipes Equinovarus 45 24
Congenital Talipes Equinovarus 45
Clubfoot 45
 
Talipes 45
Ctev 45

Classifications:



External Ids:

ICD1027 Q66.0

Summaries for Talipes Equinovarus

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NIH Rare Diseases:45 Talipes equinovarus is a congenital (present from birth) condition where the foot turns inward and downward. the cause of this condition is not known, although it may be passed down through families in some cases. this condition occurs in about 1 out of every 1,000 births. treatment may involve moving the foot into the correct position and using a cast to keep it there. this process is done in small increments over a period of time. in severe cases, surgery may be needed.  <span style="font-size: 16px;"> &lt;span style="font-size: 13px;"&gt; body {background-color: #ffffff; font-family: "times new roman"; font-size: 12pt;} &lt;/span&gt; </span> ]]> last updated: 2/27/2014

MalaCards based summary: Talipes Equinovarus, also known as congenital talipes equinovarus, is related to esophageal atresia coloboma talipes and intellectual deficit unusual facies talipes hand anomalies. An important gene associated with Talipes Equinovarus is IRF6 (Interferon Regulatory Factor 6). Affiliated tissues include brain, smooth muscle and endothelial, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

Wikipedia:68 Club foot or clubfoot, also called congenital talipes equinovarus (CTEV), is a congenital deformity... more...

Related Diseases for Talipes Equinovarus

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Graphical network of the top 20 diseases related to Talipes Equinovarus:



Diseases related to talipes equinovarus

Symptoms for Talipes Equinovarus

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Drugs & Therapeutics for Talipes Equinovarus

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Drugs for Talipes Equinovarus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AbobotulinumtoxinAPhase 4, Phase 3, Phase 2588
2IncobotulinumtoxinAPhase 4, Phase 3, Phase 2599
3OnabotulinumtoxinAPhase 4, Phase 3, Phase 2588
4Botulinum Toxins, Type APhase 4, Phase 3, Phase 2588
5
AcetylcholineexperimentalPhase 3, Phase 268951-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
Miochol E
O-Acetylcholine
acetylcholine chloride
6Neurotransmitter AgentsPhase 3, Phase 214795
7Peripheral Nervous System AgentsPhase 3, Phase 218510
8Neuromuscular AgentsPhase 3, Phase 2922
9Cholinergic AgentsPhase 3, Phase 23243
10Botulinum ToxinsPhase 3, Phase 2616
11AnestheticsPhase 37385
12Pharmaceutical SolutionsPhase 27004
13HemagglutininsPhase 2111
14Analgesics9358
15AstragalusNutraceutical48

Interventional clinical trials:

(show all 33)
idNameStatusNCT IDPhase
1Post Marketing Surveillance Study of DysportCompletedNCT00210431Phase 4
2Efficacy Study of Selective Tibial Neurotomy in the Treatment of the Spastic Equinovarus Foot Among Adult Hemiplegic PatientsCompletedNCT00825097Phase 3
3Study of GSK1358820 In Patients With Post-Stroke Lower Limb SpasticityCompletedNCT00460655Phase 3
4Treatment With Xeomin Versus Botox in Children With Spastic Equine and Equinovarus Foot Deformation in Pediatric Cerebral PalsyRecruitingNCT02188277Phase 2
5Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot)CompletedNCT00474344
6Exploring the Causes of Clubfoot Using Magnetic Resonance Imaging, MRICompletedNCT01088828
7Comparison of Casting Materials for the Treatment of Clubfoot Using the Ponseti MethodCompletedNCT01067651
8Gait Analysis in Ponseti ClubfootCompletedNCT02022267
9Outcomes of Compliance With Brace Wear in ClubfootCompletedNCT01481324
10A Randomized Controlled Trial of Three Non-pharmacologic Analgesic Techniques for Casting of Clubfoot InfantsCompletedNCT02395185
11Treatment of Spastic Equinovarus Foot After StrokeCompletedNCT00199589
12Neuro-orthopaedic Surgery in the Treatment of the Spastic Equinovarus FootCompletedNCT01265238
13Impairments of Oral Language in Mobius SyndromeCompletedNCT00856531
14Clubfoot DNA RepositoryRecruitingNCT00607191
15Bracing Compliance and Personality Traits: A Compliance Assessment Program for Scoliosis and ClubfeetRecruitingNCT02755766
16Using Botox to Treat Patients With Idiopathic ClubfootRecruitingNCT00474032
17Pedobarographic Assessments of Clubfoot Treated PatientsRecruitingNCT00175708
18Prospective Evaluation of Treatment for ClubfootRecruitingNCT02257229
19Effectiveness of Parents' Manipulation in Newborn With Talipes CalcaneusRecruitingNCT01767662
20Effectiveness of Manual Manipulation With EPAT on Ankle Dorsiflexion and Dynamic Plantar PressureRecruitingNCT02233140
21Extramembranous and Interosseous Technique of Tibialis Posterior Tendon TransferRecruitingNCT01751503
22Duration of Brace Wear in Clubfoot Treatment - A Prospective Randomized TrialActive, not recruitingNCT01551264
23Efficacy of Botox in Patients With Idiopathic ClubfootActive, not recruitingNCT00152334
24A Double-Blind, Randomized Control Trial Comparing Botulinum Toxin Type A (Botox) and Placebo in the Treatment of Idiopathic ClubfootActive, not recruitingNCT00152347
25Osteopathic Approach Into Neonatology Ward: the NE-O ModelAvailableNCT01902563
26Genetic Disease Gene IdentificationEnrolling by invitationNCT00916903
27Sucrose Analgesia in Infants Undergoing Casting for Club FootNot yet recruitingNCT01050088
28Safety and Efficacy of the Universal Neonatal Foot Orthosis in the Treatment of Metatarsus Adductus (MTA)Not yet recruitingNCT01600183
29Determination of the Pathophysicologic Collagen Changes in the Diabetic Achilles TendonSuspendedNCT01382628
30Ankle Equinus Contracture Treated With Dynamic SplintingTerminatedNCT01238484
31The Effect of Botulinum Toxin A Injections on Ankle Dorsiflexion Following Internal Fixation of Tibial Pilon FracturesTerminatedNCT02051933
32Economic Evaluation of Clubfoot Treatment: One Centre's ExperienceWithdrawnNCT00475631
33Instep Plantar Fasciotomy With and Without Gastrocnemius RecessionWithdrawnNCT02287714

Search NIH Clinical Center for Talipes Equinovarus

Genetic Tests for Talipes Equinovarus

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Anatomical Context for Talipes Equinovarus

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MalaCards organs/tissues related to Talipes Equinovarus:

33
Brain, Smooth muscle, Endothelial, Prostate, Liver, T cells, Lung

Animal Models for Talipes Equinovarus or affiliated genes

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MGI Mouse Phenotypes related to Talipes Equinovarus:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.3COL9A1, GLI3, IRF6
2MP:00053718.2COL9A1, GLI3, HOXD13, IRF6
3MP:00053908.1COL9A1, GLI3, HOXD13, IRF6

Publications for Talipes Equinovarus

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Articles related to Talipes Equinovarus:

(show top 50)    (show all 224)
idTitleAuthorsYear
1
Compartment syndrome with mononeuropathies after anterior cruciate ligament reconstruction. (25802956)
2015
2
Stigma, discrimination, treatment effectiveness, and policy: public views about drug addiction and mental illness. (25270497)
2014
3
Multiple teeth fractures in dentinogenesis imperfecta: a case report. (25571690)
2014
4
Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice. (23978715)
2014
5
PLK1 and I^-TrCP-dependent ubiquitination and degradation of Rap1GAP controls cell proliferation. (25329897)
2014
6
Severe inflammation associated with synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome was markedly ameliorated by single use of minocycline. (24533553)
2014
7
Concentration of serum interleukin-27 increase in patients with lymph node metastatic gastroesophageal cancer. (24285453)
2013
8
Risk prediction of hepatitis B virus-related hepatocellular carcinoma in the era of antiviral therapy. (24151375)
2013
9
Intraoperative hypothermia is associated with an increased intensive care unit length-of-stay in patients undergoing elective open abdominal aortic aneurysm surgery: a retrospective cohort study. (24180717)
2013
10
Hair phenotype in non-syndromic deafness. (23751281)
2013
11
Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNS. (22956843)
2012
12
Lobular endocervical glandular hyperplasia and peritoneal pigmentation associated with Peutz-Jeghers syndrome due to a germline mutation of STK11. (23038761)
2012
13
Discovery of a viral NLR homolog that inhibits the inflammasome. (21252346)
2011
14
Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups. (21267586)
2011
15
EP4 receptor stimulation down-regulates human eosinophil function. (21365278)
2011
16
Objective response to hydroxyurea in a patient with heavily pre-treated aggressive fibromatosis. (20658640)
2010
17
Treatment of relapsing polychondritis with the TNF-alpha antagonist adalimumab. (20495939)
2010
18
Effects of Podoplanin on cell proliferation and cell cycle in oral leukoplakia cells]. (20368032)
2010
19
Small cell carcinoma of the lung: an incidental finding on routine cardiac imaging. (19752008)
2010
20
Nutcracker syndrome in a child with familial Mediterranean fever (FMF) disease: renal ultrastructural features. (19031109)
2009
21
Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility. (19380721)
2009
22
Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis. (19712206)
2009
23
Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies. (19217079)
2009
24
N-terminal extension of beta B1-crystallin: identification of a critical region that modulates protein interaction with beta A3-crystallin. (19746987)
2009
25
DIXDC1 targets p21 and cyclin D1 via PI3K pathway activation to promote colon cancer cell proliferation. (19572978)
2009
26
CCR6 regulates the migration of inflammatory and regulatory T cells. (19050256)
2008
27
Significance of p57(Kip2) down-regulation in oncogenesis of bladder carcinoma: an immunohistochemical study. (18822693)
2008
28
High-density lipoprotein and the risk of recurrent venous thromboembolism. (17372172)
2007
29
Selective retina therapy in patients with central serous chorioretinopathy. (16758179)
2006
30
Analysis of cycloheximide-induced apoptosis in human leukocytes: fluorescence microscopy using annexin V/propidium iodide versus acridin orange/ethidium bromide. (16895761)
2006
31
Monitoring survival and function of transfused platelets in Glanzmann thrombasthenia by flow cytometry and thrombelastography. (16907879)
2006
32
Perceived emotional intelligence, alexithymia, coping and emotional regulation. (17295963)
2006
33
The use of topical imiquimod for the treatment of actinic keratosis: a status report. (16315560)
2005
34
Molecular analysis to demonstrate that odontogenic keratocysts are neoplastic. (14987156)
2004
35
The use of mood stabilizers as plasticity enhancers in the treatment of neuropsychiatric disorders. (12720479)
2003
36
Reactive chlorinating species produced by myeloperoxidase target the vinyl ether bond of plasmalogens: identification of 2-chlorohexadecanal. (11301330)
2001
37
Class A scavenger receptor up-regulation in smooth muscle cells by oxidized low density lipoprotein. Enhancement by calcium flux and concurrent cyclooxygenase-2 up-regulation. (10837497)
2000
38
Cicletanine reverses vasoconstriction induced by the endogenous sodium pump ligand, marinobufagenin, via a protein kinase C dependent mechanism. (10694190)
2000
39
Relation of coagulation parameters to patency and recurrent ischemia in the Thrombolysis in Myocardial Infarction (TIMI) Phase II Trial. (9453518)
1998
40
Cytokeratin-19 associated with apoptosis and chemosensitivity in human cervical cancer cells. (14646570)
1997
41
The outcome of strabismus surgery in childhood exotropia. (7867818)
1994
42
Repair of urethral diverticulum by plication. (7974950)
1994
43
Monoamine oxidase-B in astrocytes. (8406673)
1993
44
Immunological study on renal cell carcinoma in dialysis patients with acquired cystic disease of kidneys]. (1762269)
1991
45
Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man. (2378786)
1990
46
Stimulus-specific effects of pentoxifylline on neutrophil CR3 expression, degranulation, and superoxide production. (2155276)
1990
47
Le Fort II osteotomy in the treatment of maxillonasal dysostosis (Binder's syndrome). (3187793)
1988
48
Tryptophan metabolsim and serum fatty acids in acrodermatitis enteropathica. (4407531)
1974
49
Fundoscopic appearance of a nerve-fibre-bundle defect. (5079403)
1972
50

Variations for Talipes Equinovarus

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Expression for genes affiliated with Talipes Equinovarus

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Search GEO for disease gene expression data for Talipes Equinovarus.

Pathways for genes affiliated with Talipes Equinovarus

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GO Terms for genes affiliated with Talipes Equinovarus

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Biological processes related to Talipes Equinovarus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1limb morphogenesisGO:00351089.7GLI3, HOXD13
2anterior/posterior pattern specificationGO:00099529.3GLI3, HOXD13
3embryonic digit morphogenesisGO:00427339.0GLI3, HOXD13

Sources for Talipes Equinovarus

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet