MCID: TLP001
MIFTS: 34

Talipes Equinovarus malady

Rare diseases category

Aliases & Classifications for Talipes Equinovarus

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Aliases & Descriptions for Talipes Equinovarus:

Name: Talipes Equinovarus 45 24
Congenital Talipes Equinovarus 45
Clubfoot 45
 
Talipes 45
Ctev 45


Classifications:



External Ids:

ICD1027 Q66.0

Summaries for Talipes Equinovarus

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NIH Rare Diseases:45 Talipes equinovarus is a congenital (present from birth) condition where the foot turns inward and downward. the cause of this condition is not known, although it may be passed down through families in some cases. this condition occurs in about 1 out of every 1,000 births. treatment may involve moving the foot into the correct position and using a cast to keep it there. this process is done in small increments over a period of time. in severe cases, surgery may be needed.  <span style="font-size: 16px;"> &lt;span style="font-size: 13px;"&gt; body {background-color: #ffffff; font-family: "times new roman"; font-size: 12pt;} &lt;/span&gt; </span> ]]> last updated: 2/27/2014

MalaCards based summary: Talipes Equinovarus, also known as congenital talipes equinovarus, is related to clubfoot and tarp syndrome. An important gene associated with Talipes Equinovarus is RBM10 (RNA Binding Motif Protein 10). Affiliated tissues include bone, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

Wikipedia:68 Club foot or clubfoot, also called congenital talipes equinovarus (CTEV), is a congenital deformity... more...

Related Diseases for Talipes Equinovarus

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Diseases related to Talipes Equinovarus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 354)
idRelated DiseaseScoreTop Affiliating Genes
1clubfoot10.8
2tarp syndrome10.6
3myotonic dystrophy10.4
4popliteal pterygium syndrome 110.3
5acromelic frontonasal dysostosis10.3
6clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly10.3
7myelomeningocele10.3
8familial clubfoot with or without associated lower limb anomalies10.3
9ehlers-danlos syndrome, musculocontractural type10.3
10short stature robin sequence cleft mandible hand anomalies clubfoot10.3
11familial clubfoot due to 17q23.1q23.2 microduplication10.3
12familial clubfoot due to pitx1 point mutation10.3
13familial clubfoot due to 5q31 microdeletion10.3
14intellectual deficit unusual facies talipes hand anomalies10.2
15spondyloepimetaphyseal dysplasia with joint laxity, type 1, with or without fractures10.2
16ehlers-danlos syndrome, progeroid type, 210.2
17shprintzen-goldberg syndrome10.2
18ehlers-danlos syndrome, type vi10.2
19schwartz-jampel syndrome, type 110.2
20dyssegmental dysplasia, silverman-handmaker type10.2
21spinal muscular atrophy, distal, autosomal recessive, 410.2
22desmosterolosis10.2
23meier-gorlin syndrome 110.2
24spastic paraplegia 47, autosomal recessive10.2
25cousin syndrome10.2
26thrombocytopenia-absent radius syndrome10.2
27acrofacial dysostosis 1, nager type10.2
28craniofacial dysmorphism, skeletal anomalies, and mental retardation syndrome10.2
29martsolf syndrome10.2
30loeys-dietz syndrome 410.2
31chromosome 1q41-q42 deletion syndrome10.2
32prune belly syndrome10.2
33short stature with microcephaly and distinctive facies10.2
34singleton-merten syndrome 110.2
35vertical talus, congenital10.2
36chromosome 2q31.1 duplication syndrome10.2
37ehlers-danlos syndrome, type iv10.2
38glass syndrome10.2
39scapuloperoneal syndrome, neurogenic, kaeser type10.2
40arthrogryposis, distal, type 5d10.2
41ullrich congenital muscular dystrophy 110.2
42ablepharon-macrostomia syndrome10.2
43loeys-dietz syndrome 210.2
44larsen syndrome10.2
45atelosteogenesis, type i10.2
46atelosteogenesis, type iii10.2
47adams-oliver syndrome 110.2
48bruck syndrome 210.2
49congenital disorder of glycosylation, type id10.2
50wolf-hirschhorn syndrome10.2

Graphical network of the top 20 diseases related to Talipes Equinovarus:



Diseases related to talipes equinovarus

Symptoms for Talipes Equinovarus

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Drugs & Therapeutics for Talipes Equinovarus

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Drugs for Talipes Equinovarus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Botulinum Toxins, Type APhase 4, Phase 3, Phase 2561
2Botulinum ToxinsPhase 3, Phase 2590
3HemagglutininsPhase 2106
4AstragalusNutraceutical43

Interventional clinical trials:

(show all 31)
idNameStatusNCT IDPhase
1Post Marketing Surveillance Study of DysportCompletedNCT00210431Phase 4
2Efficacy Study of Selective Tibial Neurotomy in the Treatment of the Spastic Equinovarus Foot Among Adult Hemiplegic PatientsCompletedNCT00825097Phase 3
3Study of GSK1358820 In Patients With Post-Stroke Lower Limb SpasticityCompletedNCT00460655Phase 3
4Treatment With Xeomin Versus Botox in Children With Spastic Equine and Equinovarus Foot Deformation in Pediatric Cerebral PalsyRecruitingNCT02188277Phase 2
5Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot)CompletedNCT00474344
6Exploring the Causes of Clubfoot Using Magnetic Resonance Imaging, MRICompletedNCT01088828
7Comparison of Casting Materials for the Treatment of Clubfoot Using the Ponseti MethodCompletedNCT01067651
8Gait Analysis in Ponseti ClubfootCompletedNCT02022267
9Outcomes of Compliance With Brace Wear in ClubfootCompletedNCT01481324
10A Randomized Controlled Trial of Three Non-pharmacologic Analgesic Techniques for Casting of Clubfoot InfantsCompletedNCT02395185
11Treatment of Spastic Equinovarus Foot After StrokeCompletedNCT00199589
12Neuro-orthopaedic Surgery in the Treatment of the Spastic Equinovarus FootCompletedNCT01265238
13Impairments of Oral Language in Mobius SyndromeCompletedNCT00856531
14Clubfoot DNA RepositoryRecruitingNCT00607191
15Using Botox to Treat Patients With Idiopathic ClubfootRecruitingNCT00474032
16Pedobarographic Assessments of Clubfoot Treated PatientsRecruitingNCT00175708
17Prospective Evaluation of Treatment for ClubfootRecruitingNCT02257229
18Effectiveness of Parents' Manipulation in Newborn With Talipes CalcaneusRecruitingNCT01767662
19Instep Plantar Fasciotomy With and Without Gastrocnemius RecessionRecruitingNCT02287714
20Effectiveness of Manual Manipulation With EPAT on Ankle Dorsiflexion and Dynamic Plantar PressureRecruitingNCT02233140
21Extramembranous and Interosseous Technique of Tibialis Posterior Tendon TransferRecruitingNCT01751503
22Duration of Brace Wear in Clubfoot Treatment - A Prospective Randomized TrialActive, not recruitingNCT01551264
23Efficacy of Botox in Patients With Idiopathic ClubfootActive, not recruitingNCT00152334
24A Double-Blind, Randomized Control Trial Comparing Botulinum Toxin Type A (Botox) and Placebo in the Treatment of Idiopathic ClubfootActive, not recruitingNCT00152347
25Osteopathic Approach Into Neonatology Ward: the NE-O ModelAvailableNCT01902563
26Genetic Disease Gene IdentificationEnrolling by invitationNCT00916903
27Sucrose Analgesia in Infants Undergoing Casting for Club FootNot yet recruitingNCT01050088
28Determination of the Pathophysicologic Collagen Changes in the Diabetic Achilles TendonSuspendedNCT01382628
29Ankle Equinus Contracture Treated With Dynamic SplintingTerminatedNCT01238484
30The Effect of Botulinum Toxin A Injections on Ankle Dorsiflexion Following Internal Fixation of Tibial Pilon FracturesTerminatedNCT02051933
31Economic Evaluation of Clubfoot Treatment: One Centre's ExperienceWithdrawnNCT00475631

Search NIH Clinical Center for Talipes Equinovarus

Genetic Tests for Talipes Equinovarus

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Genetic tests related to Talipes Equinovarus:

id Genetic test Affiliating Genes
1 Talipes Equinovarus24

Anatomical Context for Talipes Equinovarus

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MalaCards organs/tissues related to Talipes Equinovarus:

33
Bone

Animal Models for Talipes Equinovarus or affiliated genes

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MGI Mouse Phenotypes related to Talipes Equinovarus:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.2COL9A1, GLI3, IRF6
2MP:00053718.0COL9A1, GLI3, HOXD13, IRF6
3MP:00053907.9COL9A1, GLI3, HOXD13, IRF6

Publications for Talipes Equinovarus

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Articles related to Talipes Equinovarus:

(show top 50)    (show all 223)
idTitleAuthorsYear
1
Interventions for congenital talipes equinovarus (clubfoot). (26435670)
2015
2
Open Achilles tenotomy and posterior capsulotomy for congenital talipes equinovarus. (26156730)
2015
3
Interventions for congenital talipes equinovarus (clubfoot). (25117413)
2014
4
Congenital Talipes Equinovarus: Frequency of Associated Malformations not Identified by Prenatal Ultrasound. (25394569)
2014
5
Does the Ponseti technique affect the vascular development in patients with congenital talipes equinovarus? (25229798)
2014
6
Epithelioid hemangioma of distal femoral epiphysis in a patient with congenital talipes equinovarus. (24763238)
2014
7
Osteopathic manipulative treatment of congenital talipes equinovarus: A case report. (24411143)
2014
8
Congenital idiopathic talipes equinovarus: an evaluation in infants treated by the Ponseti method. (24142617)
2013
9
Possible role of GLI3 gene in the pathogenesis of idiopathic congenital talipes equinovarus]. (22678783)
2012
10
The inter-relationship of clinical parameters in congenital talipes equinovarus: relevance to pathological anatomy and clinical classification. (23450265)
2012
11
Comparison of Ponseti versus surgical treatment in congenital talipes equinovarus. (21680202)
2011
12
Management of congenital talipes equinovarus using the Ponseti method: a systematic review. (21911524)
2011
13
The effect of neuromuscular electrical stimulation on congenital talipes equinovarus following correction with the Ponseti method: a pilot study. (20581693)
2010
14
Congenital talipes equinovarus associated with myotonic dystrophy type 2. (20665517)
2010
15
A new flexible brace used in the Ponseti treatment of talipes equinovarus. (19471177)
2008
16
Apoptotic gene analysis in idiopathic talipes equinovarus (clubfoot). (17534194)
2007
17
Histologic and histochemical analysis of muscle specimens in idiopathic talipes equinovarus. (16439910)
2006
18
Early results of a physiotherapist-delivered Ponseti service for the management of idiopathic congenital talipes equinovarus foot deformity. (16877611)
2006
19
Wound problems in surgery for talipes equinovarus. (16286376)
2005
20
Variation in CASP10 gene is associated with idiopathic talipes equinovarus. (16199938)
2005
21
Talipes equinovarus in Western Australia. (12675786)
2003
22
Peritalar release in the treatment of congenital talipes equinovarus clubfoot. (12056243)
2001
23
Resistant talipes equinovarus associated with congenital constriction band syndrome. (10739290)
2000
24
The functional outcome of staged surgery for the correction of talipes equinovarus. (10912611)
2000
25
Somatosensory evoked potentials as a means of assessing neurological abnormality in congenital talipes equinovarus. (10981930)
2000
26
Epidemiology and genetic theories in the etiology of congenital talipes equinovarus. (10431636)
1999
27
MRI multiplanar reconstruction in the assessment of congenital talipes equinovarus. (10199904)
1999
28
Congenital talipes equinovarus in spina bifida: treatment and results. (8906652)
1996
29
Intraoperative ultrasound for evaluation of reduction in congenital talipes equinovarus. (7719835)
1995
30
Relationship between acquired spastic talipes equinovarus and dystonia musculorum deformans. (8416347)
1993
31
Seasonal variation in the incidence of congenital talipes equinovarus. (2071648)
1991
32
Risk indicators for talipes equinovarus in Washington State, 1987-1989. (1912045)
1991
33
Assessment in congenital talipes equinovarus. (2210529)
1990
34
Congenital talipes equinovarus. (2391207)
1990
35
Results of surgical treatment of talipes equinovarus congenita. (2805484)
1989
36
Distal calcaneal osteotomy in resistant talipes equinovarus. (4017338)
1985
37
A higher incidence of congenital structural talipes equinovarus in gypsies. (6840781)
1983
38
Talipes equinovarus. (6554645)
1983
39
Surgical management of resistant congenital talipes equinovarus deformities. (7085691)
1982
40
HLA and clubfoot (idiopathic talipes equinovarus). (7071822)
1982
41
Early Dwyer operation in talipes equinovarus. (7471561)
1981
42
Management of congenital talipes equinovarus. (4809545)
1974
43
Practical considerations in the early treatment of congenital talipes equinovarus. (5012585)
1972
44
Congenital talipes equinovarus--fifteen years of surgical treatment. (5804493)
1969
45
Severe congenital talipes equinovarus. (5909063)
1966
46
THE GENETICS OF TALIPES EQUINOVARUS. (14133340)
1964
47
Recurring congenital talipes equinovarus. (13806063)
1960
48
Congenital talipes equinovarus. (13442744)
1957
49
Talipes equinovarus. (18131349)
1949
50
Symmetrical talipes equinovarus in identical twins. (18115536)
1949

Variations for Talipes Equinovarus

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Expression for genes affiliated with Talipes Equinovarus

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Search GEO for disease gene expression data for Talipes Equinovarus.

Pathways for genes affiliated with Talipes Equinovarus

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GO Terms for genes affiliated with Talipes Equinovarus

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Biological processes related to Talipes Equinovarus according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1pattern specification processGO:00073899.7GLI3, HOXD13
2embryonic digit morphogenesisGO:00427339.7GLI3, HOXD13
3anterior/posterior pattern specificationGO:00099529.7GLI3, HOXD13
4embryonic limb morphogenesisGO:00303269.6GLI3, HOXD13
5limb morphogenesisGO:00351089.3GLI3, HOXD13
6regulation of cell proliferationGO:00421279.0GLI3, HOXD13
7negative regulation of cell proliferationGO:00082858.9GLI3, IRF6, RBM10

Molecular functions related to Talipes Equinovarus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription factor activity, sequence-specific DNA bindingGO:00037008.8GLI3, HOXD13, IRF6

Sources for Talipes Equinovarus

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet