Talipes Equinovarus disease: drugs, articles, genes, clinical trials

Summaries for Talipes Equinovarus

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⁴⁴Wikipedia, ²²MalaCards
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Wikipedia: A club foot, or congenital talipes equinovarus (CTEV), is a congenital deformity involving one foot or...⁴⁴ more...

MalaCards: Talipes Equinovarus, also known as congenital talipes equinovarus, is related to clubfoot and brachydactyly-syndactyly syndrome. An important gene associated with Talipes Equinovarus is HOXD12 (homeobox D12), and among its related pathways are UVA-Induced MAPK Signaling and Pathogenesis of ALS. The compounds sp 600125 and ac-lehd-afc have been mentioned in the context of this disorder. Related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Descriptions for Talipes Equinovarus

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³⁰NIH Rare Diseases
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talipes equinovarus ³⁰

congenital talipes equinovarus ³⁰

clubfoot ³⁰

talipes ³⁰

ctev ³⁰

Related Diseases for Talipes Equinovarus

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¹³GeneCards, ¹⁴GeneDecks
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Diseases related to talipes equinovarus by text searches and GeneDecks gene sharing:

(show top 50) (show all 147)

id	Related Disease	Score	Top Affiliating Genes
1	clubfoot	25.7	WNT7A, NAT1, NAT2, BID, BCL2, FHL1
2	brachydactyly-syndactyly syndrome	13.4	HOXD13, HOXD12, HOXD10
3	synpolydactyly	13.4	HOXD13, HOXD12, HOXD10
4	tracheoesophageal fistula	13.1	HOXD13, GLI3
5	caspase-8 deficiency	13.1	CASP10, CASP8
6	brachydactyly	13.1	HOXD13, HOXD12, HOXD10
7	syndactyly	13.1	HOXD13, HOXD12, HOXD10, GLI3
8	short stature	12.8	SLC26A2, COL9A1, COL1A1, HOXD13
9	cerebral hypoxia	12.8	CASP3, CASP9
10	thoracic cancer	12.4	CASP3, CASP8, CASP9
11	japanese encephalitis	12.3	CASP3, CASP8, CASP9
12	lymphoproliferative syndrome	12.2	BCL2, CASP10, CASP8
13	gastrointestinal lymphoma	12.2	CASP8, BCL2
14	cleft palate	12.2	WNT7A, SLC26A2, COL9A1, NAT2, NAT1, RBM10
15	myocarditis	12.0	CASP9, CASP8, CASP3, BID
16	liposarcoma	12.0	CASP9, CASP3, CASP10, BCL2
17	synovitis	11.9	CASP9, CASP3, CASP10, BCL2
18	cataract	11.9	COL9A1, CASP9, CASP3, NAT2, NAT1
19	prostate carcinoma	11.9	NAT2, CASP8, CASP9
20	primary effusion lymphoma	11.9	CASP8, CASP3, BCL2
21	testicular cancer	11.9	CASP9, CASP8, CASP3, NAT2
22	chronic myeloid leukemia	11.8	BCL2, APAF1, CASP3, CASP9
23	malignant pleural mesothelioma	11.8	CASP3, BCL2, NAT2, NAT1
24	hearing loss	11.8	COL9A1, COL1A1, CASP9, CASP8, CASP3
25	mantle cell lymphoma	11.7	BID, BCL2, CASP3, CASP9
26	nasopharynx carcinoma	11.7	NAT2, BCL2, CASP3, CASP9
27	peripheral primitive neuroectodermal tumor	11.6	CASP9, CASP8, CASP3, BCL2
28	parkinson's disease	11.6	CASP9, CASP8, CASP3, APAF1, NAT2
29	acute promyelocytic leukemia	11.6	CASP9, CASP8, CASP3, BCL2
30	leiomyoma	11.6	WNT7A, COL1A1, CASP9, CASP3, BCL2
31	autism spectrum disorder	11.6	BCL2, APAF1, CASP3, CASP9
32	follicular lymphoma	11.5	CASP9, CASP8, CASP3, BCL2
33	b-cell lymphomas	11.5	CASP9, CASP8, CASP3, BCL2
34	toxoplasmosis	11.5	CASP9, CASP8, CASP3, BCL2
35	t-cell leukemia	11.5	BCL2, CASP3, CASP8, CASP9
36	chronic lymphocytic leukemia	11.5	CASP8, CASP3, CASP10, APAF1, BCL2
37	acute lymphoblastic leukemia	11.5	CASP8, CASP3, APAF1, BCL2
38	rhabdomyosarcoma	11.5	CASP9, CASP8, CASP10, BCL2, BID
39	lung adenocarcinoma	11.5	CASP9, CASP8, CASP3, BCL2
40	gallbladder carcinoma	11.5	CASP8, CASP3, BCL2, NAT2
41	gastrointestinal stromal tumor	11.4	CASP9, CASP8, CASP3, CASP10, BCL2
42	squamous cell carcinoma of the head and neck	11.4	CASP9, CASP8, CASP3, BCL2
43	rabies	11.3	NAT2, BCL2, CASP8, CASP9
44	germ cell tumor	11.3	CASP9, CASP8, CASP3, APAF1, BCL2
45	polyposis	11.3	CASP9, CASP3, BCL2, NAT2, NAT1
46	skin cancer	11.3	BCL2, CASP3, CASP8, CASP9
47	myopathy	11.3	COL9A1, CASP9, CASP3, FHL1, CFH, BCL2
48	non-small cell lung carcinoma	11.3	CASP9, CASP8, CASP3, APAF1, BCL2
49	burkitt's lymphoma	11.3	CASP9, CASP8, CASP3, BCL2, BID
50	non-hodgkin lymphoma	11.2	CASP8, CASP10, APAF1, BCL2, NAT2, NAT1

Graphical network of the top 20 diseases related to talipes equinovarus:

Graphical network of diseases related to talipes equinovarus

Clinical Features for Talipes Equinovarus

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Drugs & Therapeutics for Talipes Equinovarus

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⁴CenterWatch, ²⁹NIH Clinical Center, ⁵ClinicalTrials
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Genetic Tests for Talipes Equinovarus

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Anatomical Context for Talipes Equinovarus

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Phenotypes for genes affiliated with Talipes Equinovarus

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²⁵MGI
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MGI Mouse Phenotypes related to talipes equinovarus:

²⁵ (show all 18)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.9	BID, GLI3
2	endocrine/exocrine gland phenotype	MP:0005379	9.2	HOXD13, GLI3, CASP8, APAF1
3	skeleton phenotype	MP:0005390	8.4	COL9A1, APAF1, HOXD10, HOXD12, HOXD13, SLC26A2
4	limbs/digits/tail phenotype	MP:0005371	8.4	PITX1, GLI3, APAF1, HOXD12, HOXD13, COL1A1
5	reproductive system phenotype	MP:0005389	8.4	WNT7A, HOXD12, HOXD10, GLI3, CASP3, NAT1
6	mortality/aging	MP:0010768	8.1	HOXD13, PITX1, SLC26A2, GLI3, WNT7A, HOXD10
7	hearing/vestibular/ear phenotype	MP:0005377	8.0	APAF1, CASP3, GLI3, COL9A1, COL1A1, BCL2
8	muscle phenotype	MP:0005369	7.9	BID, PITX1, COL1A1, HOXD13, HOXD12, HOXD10
9	digestive/alimentary phenotype	MP:0005381	7.7	HOXD12, GLI3, CASP3, COL1A1, HOXD13, APAF1
10	craniofacial phenotype	MP:0005382	7.4	SLC26A2, PITX1, COL1A1, GLI3, CASP9, CASP3
11	renal/urinary system phenotype	MP:0005367	7.4	CFH, CASP8, GLI3, HOXD13, CASP3, BCL2
12	vision/eye phenotype	MP:0005391	7.3	COL1A1, HOXD13, GLI3, CASP3, APAF1, BCL2
13	embryogenesis phenotype	MP:0005380	6.7	WNT7A, APAF1, CASP3, CASP8, HOXD12, NAT1
14	growth/size phenotype	MP:0005378	6.5	HOXD13, BCL2, FHL1, CASP3, CASP8, CASP9
15	cellular phenotype	MP:0005384	6.0	CASP3, CASP8, CASP9, GLI3, HOXD10, APAF1
16	cardiovascular system phenotype	MP:0005385	5.9	WNT7A, BID, CASP3, APAF1, CASP8, CASP9
17	homeostasis/metabolism phenotype	MP:0005376	5.8	NAT2, GLI3, CASP8, COL9A1, COL1A1, NAT1
18	nervous system phenotype	MP:0003631	5.4	BID, COL1A1, BCL2, HOXD12, HOXD10, GLI3

Publications for genes affiliated with Talipes Equinovarus

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³⁵PubMed
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Articles related to talipes equinovarus:

(show all 11)

id	Title	Authors	Year	Affiliating Genes
1	Expression of COL9A1 gene and its polymorphism in ch ildren with idiopathic congenital talipes equinovarus]. (21672422)	Liu L.Y.... Lin C.K.	2011	COL9A1
2	The expression of Gli3, regulated by HOXD13, may play a role in idiopathic congenital talipes equinovarus. (19925654)	Cao D.... Zhao N.	2009	GLI3
3	Variation in WNT7A is unlikely to be a cause of familial congenital talipes equinovarus. (18538017)	Liu G.... Miedzybrodzka Z.	2008	WNT7A
4	Research of HOXD13 and FHL1 in idiopathic congenital talipes equinovarus (18244901)	Wang L.L.... Sun K.L.	2008	CFH, FHL1, HOXD13
5	Association study between mutations of transcription regulator sequences of COL1A1 gene and idiopathic con-genital talipes equinovarus. (18550494)	Zhao N.... Sun K.L.	2008	COL1A1
6	Apoptotic gene analysis in idiopathic talipes equinovarus (clubfoot). (17534194)	Ester A.R.... Hecht J.T.	2007	BCL2, CASP3, CASP10
7	Analysis of association between COL9A1 gene and idiopathic congenital talipes equinovarus (17548304)	Liu L.Y.... Sun K.L.	2007	COL9A1
8	NAT2 variation and idiopathic talipes equinovarus (clubfoot). (17726690)	Hecht J.T.... Blanton S.H.	2007	NAT1, NAT2
9	Association and mutation analysis of GLI3 gene in idiopathic congenital talipes equinovarus (17029207)	Zhang X.... Sun K.L.	2006	GLI3
10	Analysis of association between 5' HOXD gene and idiopathic congenital talipes equinovarus (16331564)	Wang L.L.... Sun K.L.	2005	HOXD10, HOXD13, HOXD12
11	DTDST mutations are not a frequent cause of idiopathic talipes equinovarus (club foot). (11950872)	Bonafe L.... Hecht J.T.	2002	SLC26A2

Genes related to Talipes Equinovarus

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¹³GeneCards
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Genes related to talipes equinovarus according to GeneCards:

(show all 21)

id	Symbol	Description	Score	GeneCards Section Context
1	HOXD12	homeobox D12	11.0	Publications
2	HOXD10	homeobox D10	11.0	Publications
3	HOXD13	homeobox D13	11.0	Publications
4	PITX1	paired-like homeodomain 1	11.0
5	SLC26A2	solute carrier family 26 (sulfate transporter), member 2	11.0	Publications
6	FHL1	four and a half LIM domains 1	11.0	Publications
7	COL9A1	collagen, type IX, alpha 1	11.0	Publications
8	RBM10	RNA binding motif protein 10	11.0
9	WNT7A	wingless-type MMTV integration site family, member 7A	11.0	Publications
10	CASP10	caspase 10, apoptosis-related cysteine peptidase	11.0	Publications
11	APAF1	apoptotic peptidase activating factor 1	11.0	Publications
12	NAT1	N-acetyltransferase 1 (arylamine N-acetyltransferase)	11.0	Publications
13	GLI3	GLI family zinc finger 3	11.0	Publications
14	COL1A1	collagen, type I, alpha 1	11.0	Publications
15	BID	BH3 interacting domain death agonist	11.0	Publications
16	CFH	complement factor H	11.0	Publications
17	NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	11.0	Publications
18	CASP9	caspase 9, apoptosis-related cysteine peptidase	11.0	Publications
19	CASP8	caspase 8, apoptosis-related cysteine peptidase	11.0	Publications
20	CASP3	caspase 3, apoptosis-related cysteine peptidase	11.0	Publications
21	BCL2	B-cell CLL/lymphoma 2	11.0	Publications

Expression for genes affiliated with Talipes Equinovarus

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¹BioGPS
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Expression patterns in normal tissues for genes affiliated with Talipes Equinovarus

Pathways for genes affiliated with Talipes Equinovarus

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³⁶QIAGEN, ⁴¹Thomson Reuters, ¹⁰EMD Millipore, ²⁰KEGG, ³⁷R&D Systems, ³Cell Signaling Technology
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Pathways related to talipes equinovarus according to GeneDecks:

(show top 50) (show all 63)

id	Pathway	Score	Top Affiliating Genes
1	UVA-Induced MAPK Signaling³⁶	9.1	CASP8, CASP3
2	Pathogenesis of ALS³⁶	8.6	CASP3, CASP9, BCL2
3	Nur77 Signaling in T-Cell³⁶	8.6	APAF1, CASP9, CASP3, BCL2
4	Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins⁴¹	8.5	BID, APAF1, CASP8, CASP9, BCL2
5	Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins¹⁰	8.5	CASP9, CASP8, BID, BCL2, APAF1
6	GITR Pathway³⁶	8.5	CASP8, CASP3, CASP9, CASP10
7	Apoptosis and survival_Role of CDK5 in neuronal death and survival⁴¹	8.5	CASP3, CASP9, APAF1, BCL2
8	Apoptosis and survival Role of CDK5 in neuronal death and survival¹⁰	8.5	APAF1, CASP9, CASP3, BCL2
9	TNF-Induced Apoptosis Implicating Sphingolipids³⁶	8.4	CASP9, CASP8, CASP3, CASP10
10	Apoptotic Pathways Triggered By HIV1³⁶	8.3	CASP9, BID, APAF1, CASP3, BCL2
11	Amyotrophic lateral sclerosis (ALS)²⁰	8.3	CASP9, BCL2, CASP3, APAF1, BID
12	Granzyme-B Pathway³⁶	8.3	BID, CASP3, CASP8, CASP9, APAF1
13	Granzyme Pathway³⁶	8.3	BID, CASP9, CASP8, CASP3, APAF1
14	DR3 Signaling³⁶	8.3	CASP9, CASP3, BID, APAF1, CASP8
15	TWEAK Pathway³⁶	8.3	BID, APAF1, CASP3, CASP8, CASP9
16	TRAIL Pathway³⁶	8.3	BID, CASP3, CASP8, APAF1, CASP9
17	CTL Mediated Apoptosis³⁶	8.2	BID, CASP9, CASP3, CASP8, APAF1
18	all-trans-Retinoic Acid Mediated Apoptosis³⁶	8.2	BID, CASP8, CASP9, CASP3, APAF1
19	TNFR1 Pathway³⁶	8.2	CASP3, CASP9, BID, CASP8, APAF1
20	TNF Signaling³⁶	8.2	CASP3, BID, CASP9, APAF1, CASP8
21	p53 signaling pathway²⁰	8.2	CASP8, BID, APAF1, CASP3, CASP9
22	S-1P Stimulated Signaling³⁶	8.1	CASP10, CASP9, CASP8, CASP3
23	Viral myocarditis²⁰	8.1	BID, CASP3, CASP8, CASP9
24	Apoptosis and survival_Caspase cascade⁴¹	8.0	BID, APAF1, CASP10, CASP3, CASP8, CASP9
25	Ceramide Pathway³⁶	8.0	CASP3, CASP8, CASP10, CASP9, BCL2
26	Apoptosis and survival Caspase cascade¹⁰	8.0	CASP9, CASP3, CASP10, APAF1, CASP8, BID
27	Fas Signaling³⁶	8.0	CASP9, CASP3, BID, APAF1, CASP10, CASP8
28	Caspase Cascade³⁶	8.0	BID, CASP9, CASP8, CASP3, CASP10, APAF1
29	Alzheimers disease²⁰	8.0	CASP9, CASP8, CASP3, APAF1, BID
30	TNF Superfamily Pathway³⁶	7.9	CASP10, CASP3, CASP9, CASP8
31	p53 Signaling³⁶	7.9	CASP8, CASP3, CASP9, CASP10, BCL2
32	Presenilin-Mediated Signaling³⁶	7.8	CASP9, CASP8, CASP3, CASP10, BCL2, WNT7A
33	Apoptosis and survival Apoptotic TNF-family pathways¹⁰	7.8	CASP8, CASP3, CASP10, BCL2, CASP9, BID
34	Apoptosis and survival_Apoptotic TNF-family pathways⁴¹	7.8	CASP9, CASP8, CASP3, CASP10, BID, BCL2
35	14-3-3 Induced Apoptosis³⁶	7.8	CASP9, BID, BCL2, CASP8, CASP10, CASP3
36	Pathways in cancer²⁰	7.7	CASP8, BCL2, CASP3, GLI3, CASP9, WNT7A
37	p53 Mediated Apoptosis³⁶	7.7	BID, BCL2, CASP9, CASP8, CASP3, APAF1
38	Mitochondrial Apoptosis³⁶	7.6	CASP3, APAF1, BCL2, BID, CASP9, CASP8
39	Molecular Mechanisms of Cancer³⁶	7.6	CASP8, COL1A1, CASP3, APAF1, BCL2, BID
40	Cellular Apoptosis Pathway³⁶	7.6	CASP8, BID, BCL2, APAF1, CASP3, CASP9
41	Apoptosis and survival FAS signaling cascades¹⁰	7.5	BCL2, CASP10, BID, APAF1, CASP3, CASP8
42	Apoptosis and survival_FAS signaling cascades⁴¹	7.5	BID, BCL2, CASP8, CASP9, CASP3, CASP10
43	Apoptosis and survival_TNFR1 signaling pathway⁴¹	7.5	BID, CASP9, BCL2, APAF1, CASP10, CASP3
44	Apoptosis and survival TNFR1 signaling pathway¹⁰	7.5	CASP9, CASP8, CASP3, CASP10, APAF1, BCL2
45	Apoptosis through Death Receptors³⁶	7.5	CASP9, BID, BCL2, APAF1, CASP10, CASP3
46	Apoptosis Signaling Pathways³⁷	7.5	BCL2, APAF1, CASP10, CASP3, CASP9, CASP8
47	Apoptosis²⁰	7.5	CASP10, BCL2, BID, CASP8, CASP3, CASP9
48	Apoptosis and Autophagy³	7.4	BID, BCL2, APAF1, CASP10, CASP3, CASP8
49	Tuberculosis²⁰	7.4	CASP3, BID, BCL2, APAF1, CASP10, CASP8
50	DHA Signaling³⁶	7.4	BID, BCL2, CASP10, APAF1, CASP8, CASP3

Compounds for genes affiliated with Talipes Equinovarus

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Sources:
³²Novoseek , ⁴²Tocris Bioscience, ⁹DrugBank, ¹⁸HMDB, ³⁴PharmGKB
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Compounds related to talipes equinovarus according to GeneDecks:

(show top 50) (show all 118)

id	Compound	Score	Top Affiliating Genes
1	sp 600125³² ⁴²	10.6	CASP3, BID
2	ac-lehd-afc⁴²	9.3	CASP9, CASP10, CASP8
3	oridonin³²	8.9	CASP3, CASP9, BCL2
4	2-chlorodeoxyadenosine³²	8.9	BCL2, APAF1, CASP8, CASP9
5	cardiolipin³² ⁹ ⁹	10.9	BID, CASP8, CASP9, CFH
6	d-api³²	8.8	CASP9, CASP8, CASP3
7	fludarabine³² ⁹ ⁹	10.8	CASP8, APAF1, BCL2, BID
8	beta-lapachone³²	8.7	CASP9, BCL2, CASP3
9	2-methoxyestradiol³² ¹⁸	9.7	CASP8, BCL2, BID, CASP9
10	ursolic acid³²	8.6	BCL2, CASP8, CASP3
11	parthenolide³²	8.5	BID, CASP3, CASP8, CASP9
12	bongkrekic acid³²	8.4	CASP9, CASP8, CASP3, BCL2
13	shikonin³²	8.4	BCL2, CASP3, CASP8, CASP9
14	betulinic acid³²	8.4	CASP3, BCL2, CASP9, CASP8
15	vitamin e succinate³²	8.4	CASP3, CASP9, CASP8, BCL2
16	sulindac sulfide³²	8.4	CASP9, CASP3, BCL2, CASP8
17	triptolide³²	8.3	CASP3, CASP9, CASP8, BCL2
18	indole-3-carbinol³²	8.3	CASP9, CASP8, CASP3, BCL2
19	dutp³²	8.3	CASP8, BCL2, CASP3, CASP9
20	sulforaphane³²	8.3	CASP9, CASP8, CASP3, BCL2
21	depsipeptide³²	8.2	CASP8, CASP3, CASP9, BCL2
22	n-(4-hydroxyphenyl)retinamide³²	8.2	CASP3, BCL2, CASP8, CASP9
23	z-vad-fmk³² ⁴²	9.2	BCL2, CASP10, CASP3, CASP8, CASP9
24	celecoxib³² ⁴² ³⁴ ⁹ ¹⁸ ⁹	13.1	APAF1, CASP3, CASP8, CASP9, BCL2
25	lactacystin³²	8.1	CASP3, CASP8, APAF1, CASP9, BCL2
26	4,6-diamidino-2-phenylindole³²	8.1	BCL2, BID, CASP3, CASP8, CASP9
27	sanguinarine³²	8.1	BCL2, BID, CASP3, CASP8, CASP9
28	phenethyl isothiocyanate³²	8.1	BID, CASP3, BCL2, CASP9, CASP8
29	cd 437³²	8.0	BID, CASP3, CASP9, BCL2, CASP8
30	suberoylanilide hydroxamic acid³²	8.0	BID, BCL2, CASP3, CASP8, CASP9
31	flavopiridol³² ⁹ ⁹	10.0	CASP8, CASP3, CASP9, BCL2, BID
32	docetaxel³² ³⁴ ⁹ ⁹	11.0	CASP8, CASP3, BID, CASP9, BCL2
33	c2ceramide³²	8.0	CASP9, CASP3, BCL2, CASP8
34	gemcitabine³² ³⁴ ⁹ ⁹	11.0	BID, CASP9, CASP8, CASP3, BCL2
35	mg 132³² ⁴²	8.8	CASP8, BID, BCL2, CASP9, CASP3
36	imatinib³² ³⁴ ⁹ ⁹	10.8	BCL2, COL1A1, CASP8, CASP3, BID
37	noxa³²	7.8	APAF1, CASP8, BID, BCL2, CASP9, CASP3
38	bortezomib³² ⁹ ⁹	9.8	BCL2, APAF1, CASP3, CASP8, CASP9, BID
39	adpribose³²	7.8	CASP9, CASP8, CASP3, APAF1, BCL2, BID
40	resveratrol³² ⁹ ¹⁸ ⁹	10.8	BID, APAF1, CASP8, CASP3, CASP9, BCL2
41	camptothecin³² ⁴² ⁹ ⁹	10.7	CASP9, CASP8, BID, BCL2, APAF1, CASP3
42	phosphatidylserine³² ⁹ ⁹	9.7	CASP3, CASP8, CASP9, BCL2, BID, APAF1
43	curcumin³²	7.7	CASP9, CASP8, NAT1, BID, BCL2, CASP3
44	etoposide³² ⁴² ⁹ ⁹	10.7	BCL2, APAF1, CASP3, BID, CASP8, CASP9
45	dexamethasone³² ⁴² ³⁴ ⁹ ⁹	11.4	CASP9, CASP8, APAF1, CFH, BCL2, NAT2
46	ceramide³²	7.3	BCL2, CASP3, CASP8, CASP9, BID
47	cisplatin³² ³⁴ ⁹ ⁹	10.3	BCL2, CASP3, BID, APAF1, CASP8, CASP9
48	doxorubicin³² ³⁴ ⁹ ⁹	10.2	CASP9, CASP3, APAF1, CASP8, BCL2, BID
49	paclitaxel³² ³⁴ ⁹ ⁹	10.2	CASP3, NAT1, BCL2, BID, APAF1, CASP9
50	cysteine³²	6.9	COL1A1, SLC26A2, CASP9, CASP8, CASP3, APAF1

GO Terms for genes affiliated with Talipes Equinovarus

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¹²Gene Ontology
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Cellular components related to talipes equinovarus according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	apoptosome	GO:043293	9.7	APAF1, CASP9
2	cytosol	GO:005829	5.5	NAT1, GLI3, CASP9, CASP8, CASP3, CASP10

Biological processes related to talipes equinovarus according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	embryonic digit morphogenesis	GO:042733	9.8	WNT7A, GLI3, HOXD12, HOXD13
2	glial cell apoptotic process	GO:034349	9.7	BCL2, BID
3	anterior/posterior pattern specification	GO:009952	9.7	HOXD13, GLI3, HOXD10
4	skeletal system development	GO:001501	9.6	HOXD12, HOXD13, PITX1, COL1A1
5	organ morphogenesis	GO:009887	9.5	FHL1, BCL2, COL9A1
6	regulation of mitochondrial membrane permeability	GO:046902	9.3	BID, BCL2
7	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	GO:008635	9.1	CASP9, CASP3, APAF1
8	activation of pro-apoptotic gene products	GO:008633	9.0	BCL2, CASP8, BID
9	release of cytochrome c from mitochondria	GO:001836	8.9	CASP3, BCL2, BID
10	neuron apoptotic process	GO:051402	8.9	CASP3, BCL2, BID
11	induction of apoptosis by intracellular signals	GO:008629	7.6	BID, BCL2, APAF1, CASP3, CASP8, CASP9
12	apoptotic process	GO:006915	7.3	CASP9, CASP8, BID, BCL2, APAF1, CASP3

Molecular functions related to talipes equinovarus according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	arylamine N-acetyltransferase activity	GO:004060	9.7	NAT2, NAT1
2	sequence-specific DNA binding	GO:043565	8.6	PITX1, HOXD13, HOXD12, HOXD10, GLI3, BCL2
3	cysteine-type endopeptidase activity	GO:004197	8.1	CASP10, CASP3, CASP8, CASP9

Sources for Talipes Equinovarus

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CTEV MCID: TLP001	Talipes Equinovarus malady MalaCards information score (MIFTS): 48.2
21 genes, 150 related diseases, 18 phenotypes, 11 articles, clinical trials.

Talipes Equinovarus malady

Summaries for Talipes Equinovarus

Aliases & Descriptions for Talipes Equinovarus

Related Diseases for Talipes Equinovarus

Diseases related to talipes equinovarus by text searches and GeneDecks gene sharing:

Graphical network of the top 20 diseases related to talipes equinovarus:

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Genes related to talipes equinovarus according to GeneCards:

Expression for genes affiliated with Talipes Equinovarus

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Pathways related to talipes equinovarus according to GeneDecks:

Compounds for genes affiliated with Talipes Equinovarus

Compounds related to talipes equinovarus according to GeneDecks:

GO Terms for genes affiliated with Talipes Equinovarus

Cellular components related to talipes equinovarus according to GeneDecks:

Biological processes related to talipes equinovarus according to GeneDecks:

Molecular functions related to talipes equinovarus according to GeneDecks:

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