CTEV
MCID: TLP001
MIFTS: 56

Talipes Equinovarus (CTEV) malady

Rare diseases category
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Summaries for Talipes Equinovarus

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NIH Rare Diseases:42 Talipes equinovarus is a congenital (present from birth) condition where the foot turns inward and downward. the cause of this condition is not known, although it may be passed down through families in some cases. this condition occurs in about 1 out of every 1,000 births. treatment may involve moving the foot into the correct position and using a cast to keep it there. this process is done in small increments over a period of time. in severe cases, surgery may be needed.  <span style="font-size: 16px;"> &lt;span style="font-size: 13px;"&gt; body {background-color: #ffffff; font-family: "times new roman"; font-size: 12pt;} &lt;/span&gt; </span> ]]> last updated: 2/27/2014

MalaCards based summary: Talipes Equinovarus, also known as congenital talipes equinovarus, is related to clubfoot and polydactyly. An important gene associated with Talipes Equinovarus is HOXD13 (homeobox D13), and among its related pathways are EGFR Signaling Pathway and LT-BetaR Pathway. The compounds d-api and z-dqmd-fmk have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are taste/olfaction and pigmentation.

Wikipedia:65 Club foot or clubfoot, also called congenital talipes equinovarus (CTEV), is a congenital deformity... more...

Aliases & Classifications for Talipes Equinovarus

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Talipes Equinovarus, Aliases & Descriptions:

Name: Talipes Equinovarus 42 22
Congenital Talipes Equinovarus 42
Clubfoot 42
 
Talipes 42
Ctev 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

ICD1025 Q66.0

Related Diseases for Talipes Equinovarus

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Diseases related to Talipes Equinovarus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 236)
idRelated DiseaseScoreTop Affiliating Genes
1clubfoot31.5HOXD10, HOXD13, COL9A1, GLI3, SLC26A2
2polydactyly30.4HOXD12, HOXD13, GLI3
3syndactyly30.3GLI3, HOXD13, HOXD12
4multiple epiphyseal dysplasia30.3COL9A1, SLC26A2
5brachydactyly-syndactyly syndrome10.6HOXD13
6tarp syndrome10.5
7myotonic dystrophy10.5
8myocardial infarction10.5CFH
9adducted thumb and clubfoot syndrome10.4
10clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly10.4
11myotonic dystrophy type 210.4
12myelomeningocele10.4
13pseudoachondroplasia10.4SLC26A2, COL9A1
14otosclerosis10.2COL1A1, SLC26A2
15lumbar disc disease10.2COL1A1
16familial clubfoot due to 17q23.1q23.2 microduplication10.2
17hemangioma10.2
18spina bifida10.2
19eunuchism10.2
20compartment syndrome10.2
21dystonia10.2
22kabuki syndrome10.2
23acromelic frontonasal dysostosis10.2
24agenesis of the corpus callosum10.2
25camptodactyly joint contractures and facial skeletal dysplasia10.2
26crane-heise syndrome10.2
27fertile eunuch syndrome10.2
28metatarsus adductus10.2
29vertical talus, congenital10.2
30spasticity10.2
31autoimmune lymphoproliferative syndrome10.2CASP10, CASP8
32transitional cell carcinoma10.2NAT1, NAT2, APAF1
33pseudohypoaldosteronism type ii10.2
34multiple epiphyseal dysplasia 410.2
35richieri costa pereira syndrome10.2
36short stature robin sequence cleft mandible hand anomalies clubfoot10.2
37familial clubfoot due to 5q31 microdeletion10.2
38intellectual deficit unusual facies talipes hand anomalies10.2
39cholangiocarcinoma10.2CASP9, NAT1, NAT2
40systemic scleroderma10.2COL1A1
41cataract10.1NAT2, NAT1, CASP9
42esophageal atresia coloboma talipes10.1
43short stature talipes natal teeth10.1
44xeroderma talipes enamel defects10.1
45cleft palate10.1
46spondyloepiphyseal dysplasia with congenital joint dislocations10.1
47ehlers-danlos syndrome10.1
48atelosteogenesis type 210.1
49arthrogryposis multiplex congenita distal type 110.1
50moebius syndrome10.1

Graphical network of the top 20 diseases related to Talipes Equinovarus:



Diseases related to talipes equinovarus

Symptoms for Talipes Equinovarus

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Drugs & Therapeutics for Talipes Equinovarus

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Drug clinical trials:

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Genetic Tests for Talipes Equinovarus

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Genetic tests related to Talipes Equinovarus:

id Genetic test Affiliating Genes
1 Talipes Equinovarus22

Anatomical Context for Talipes Equinovarus

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MalaCards organs/tissues related to Talipes Equinovarus:

32
Bone

Animal Models for Talipes Equinovarus or affiliated genes

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MGI Mouse Phenotypes related to Talipes Equinovarus:

36 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.3GLI3, CASP9, CASP3
2MP:00011868.4CFH, COL1A1, BCL2, CASP3, GLI3
3MP:00053778.2APAF1, WNT7A, COL1A1, COL9A1, BCL2, CASP3
4MP:00053678.1HOXD10, HOXD13, CFH, BCL2, CASP8, CASP3
5MP:00053828.0APAF1, COL1A1, BCL2, CASP3, CASP9, GLI3
6MP:00053718.0HOXD10, HOXD12, HOXD13, APAF1, WNT7A, COL1A1
7MP:00107717.8HOXD13, WNT7A, COL1A1, BCL2, CASP8, CASP3
8MP:00053807.5HOXD12, HOXD13, APAF1, NAT1, WNT7A, COL1A1
9MP:00053817.5HOXD12, HOXD13, APAF1, COL1A1, BCL2, CASP3
10MP:00053797.5HOXD13, APAF1, COL1A1, BCL2, CASP8, CASP3
11MP:00053907.4APAF1, HOXD13, HOXD12, HOXD10, WNT7A, COL1A1
12MP:00053887.4APAF1, COL1A1, BCL2, CASP8, CASP3, CASP9
13MP:00053867.1HOXD10, APAF1, WNT7A, FHL1, COL1A1, BCL2
14MP:00053787.1HOXD13, FHL1, COL1A1, BCL2, CASP8, CASP3
15MP:00053697.0HOXD10, HOXD12, HOXD13, COL1A1, BCL2, CASP8
16MP:00053846.9BCL2, COL1A1, APAF1, HOXD10, CASP8, CASP3
17MP:00053876.8CFH, APAF1, COL1A1, COL9A1, BCL2, CASP8
18MP:00053896.6HOXD10, HOXD12, HOXD13, APAF1, NAT2, NAT1
19MP:00053916.6HOXD13, CFH, APAF1, NAT1, WNT7A, FHL1
20MP:00053856.6CFH, APAF1, WNT7A, FHL1, COL1A1, BCL2
21MP:00053766.5CFH, NAT2, NAT1, FHL1, COL1A1, COL9A1
22MP:00107685.4WNT7A, APAF1, CFH, HOXD13, HOXD12, HOXD10
23MP:00036315.1GLI3, HOXD10, HOXD12, HOXD13, CFH, APAF1

Publications for Talipes Equinovarus

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Articles related to Talipes Equinovarus:

(show top 50)    (show all 213)
idTitleAuthorsYear
1
Interventions for congenital talipes equinovarus (clubfoot). (25117413)
2014
2
Congenital Talipes Equinovarus: Frequency of Associated Malformations not Identified by Prenatal Ultrasound. (25394569)
2014
3
Does the Ponseti technique affect the vascular development in patients with congenital talipes equinovarus? (25229798)
2014
4
Epithelioid hemangioma of distal femoral epiphysis in a patient with congenital talipes equinovarus. (24763238)
2014
5
Osteopathic manipulative treatment of congenital talipes equinovarus: A case report. (24411143)
2014
6
Congenital idiopathic talipes equinovarus: an evaluation in infants treated by the Ponseti method. (24142617)
2013
7
Possible role of GLI3 gene in the pathogenesis of idiopathic congenital talipes equinovarus]. (22678783)
2012
8
The inter-relationship of clinical parameters in congenital talipes equinovarus: relevance to pathological anatomy and clinical classification. (23450265)
2012
9
Comparison of Ponseti versus surgical treatment in congenital talipes equinovarus. (21680202)
2011
10
Management of congenital talipes equinovarus using the Ponseti method: a systematic review. (21911524)
2011
11
The effect of neuromuscular electrical stimulation on congenital talipes equinovarus following correction with the Ponseti method: a pilot study. (20581693)
2010
12
Congenital talipes equinovarus associated with myotonic dystrophy type 2. (20665517)
2010
13
A new flexible brace used in the Ponseti treatment of talipes equinovarus. (19471177)
2008
14
Apoptotic gene analysis in idiopathic talipes equinovarus (clubfoot). (17534194)
2007
15
Histologic and histochemical analysis of muscle specimens in idiopathic talipes equinovarus. (16439910)
2006
16
Early results of a physiotherapist-delivered Ponseti service for the management of idiopathic congenital talipes equinovarus foot deformity. (16877611)
2006
17
Wound problems in surgery for talipes equinovarus. (16286376)
2005
18
Variation in CASP10 gene is associated with idiopathic talipes equinovarus. (16199938)
2005
19
Talipes equinovarus in Western Australia. (12675786)
2003
20
Peritalar release in the treatment of congenital talipes equinovarus clubfoot. (12056243)
2001
21
Evaluation of foot bimalleolar angle in the management of congenital talipes equinovarus. (11176354)
2001
22
Resistant talipes equinovarus associated with congenital constriction band syndrome. (10739290)
2000
23
The functional outcome of staged surgery for the correction of talipes equinovarus. (10912611)
2000
24
Somatosensory evoked potentials as a means of assessing neurological abnormality in congenital talipes equinovarus. (10981930)
2000
25
Epidemiology and genetic theories in the etiology of congenital talipes equinovarus. (10431636)
1999
26
MRI multiplanar reconstruction in the assessment of congenital talipes equinovarus. (10199904)
1999
27
Congenital talipes equinovarus in spina bifida: treatment and results. (8906652)
1996
28
Intraoperative ultrasound for evaluation of reduction in congenital talipes equinovarus. (7719835)
1995
29
Relationship between acquired spastic talipes equinovarus and dystonia musculorum deformans. (8416347)
1993
30
Seasonal variation in the incidence of congenital talipes equinovarus. (2071648)
1991
31
Risk indicators for talipes equinovarus in Washington State, 1987-1989. (1912045)
1991
32
Assessment in congenital talipes equinovarus. (2210529)
1990
33
Congenital talipes equinovarus. (2391207)
1990
34
Results of surgical treatment of talipes equinovarus congenita. (2805484)
1989
35
Congenital talipes equinovarus. (3647366)
1987
36
Distal calcaneal osteotomy in resistant talipes equinovarus. (4017338)
1985
37
A higher incidence of congenital structural talipes equinovarus in gypsies. (6840781)
1983
38
Talipes equinovarus. (6554645)
1983
39
Surgical management of resistant congenital talipes equinovarus deformities. (7085691)
1982
40
HLA and clubfoot (idiopathic talipes equinovarus). (7071822)
1982
41
Early Dwyer operation in talipes equinovarus. (7471561)
1981
42
Management of congenital talipes equinovarus. (4809545)
1974
43
Practical considerations in the early treatment of congenital talipes equinovarus. (5012585)
1972
44
Congenital talipes equinovarus--fifteen years of surgical treatment. (5804493)
1969
45
Severe congenital talipes equinovarus. (5909063)
1966
46
THE GENETICS OF TALIPES EQUINOVARUS. (14133340)
1964
47
Recurring congenital talipes equinovarus. (13806063)
1960
48
Congenital talipes equinovarus. (13442744)
1957
49
Talipes equinovarus. (18131349)
1949
50
Symmetrical talipes equinovarus in identical twins. (18115536)
1949

Variations for Talipes Equinovarus

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Expression for genes affiliated with Talipes Equinovarus

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Expression patterns in normal tissues for genes affiliated with Talipes Equinovarus

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Pathways for genes affiliated with Talipes Equinovarus

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Pathways related to Talipes Equinovarus according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CASP10, CASP9, CASP3
2
Show member pathways
Apoptosis and survival Lymphotoxin beta receptor signaling60
9.4CASP3, CASP9, APAF1
39.4CASP3, APAF1, CASP9
4
Show member pathways
9.4APAF1, CASP3, CASP9
5
Show member pathways
9.4CASP3, APAF1, CASP9
6
Show member pathways
9.4APAF1, CASP3, CASP9
7
Show member pathways
Catalytic cycle of mammalian FMOs37
9.2NAT2, BCL2, NAT1
89.2CASP9, CASP3, CASP8
9
Show member pathways
9.0CASP3, CASP9, CASP8, CASP10
10
Show member pathways
9.0CASP10, CASP9, CASP3, CASP8
119.0CASP9, CASP10, CASP3, CASP8
129.0APAF1, CASP8, CASP3, CASP9
138.9BID, CASP8, BCL2
148.9APAF1, CASP10, BID, BCL2
15
Show member pathways
TRAIL signaling pathway37
8.8BID, CASP8, CASP3, CASP10
168.8CASP3, BCL2, CASP9, APAF1
17
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
8.8BCL2, CASP9, CASP3, APAF1
18
Show member pathways
8.7CASP9, CASP8, CASP3, BID
19
Show member pathways
8.6CASP9, CASP3, CASP8, BCL2
20
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
8.6CASP3, CASP8, BCL2, CASP9
218.4APAF1, CASP3, BID, CASP8, CASP9
22
Show member pathways
Alzheimers Disease37
8.4CASP8, CASP3, APAF1, BID, CASP9
23
Show member pathways
8.4APAF1, CASP3, CASP9, BID, CASP8
24
Show member pathways
8.4CASP9, CASP8, BID, APAF1, CASP3
25
Show member pathways
8.4CASP8, BID, CASP9, APAF1, CASP3
26
Show member pathways
DNA damage response37
8.4APAF1, CASP9, BID, CASP8, CASP3
27
Show member pathways
8.4CASP9, BCL2, CASP10, CASP3, CASP8
28
Show member pathways
8.4CASP10, CASP8, BCL2, CASP3, CASP9
29
Show member pathways
8.4CASP3, CASP10, BCL2, CASP9, CASP8
30
Show member pathways
8.4BCL2, CASP9, CASP10, CASP8, CASP3
31
Show member pathways
8.3BID, CASP8, BCL2, APAF1, CASP9
32
Show member pathways
8.3CASP9, CASP10, BCL2, CASP3, BID
33
Show member pathways
8.2BID, CASP9, CASP3, CASP10, APAF1, CASP8
34
Show member pathways
Amyotrophic lateral sclerosis (ALS)37
8.2BID, APAF1, CASP9, BCL2, CASP3
35
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.1APAF1, CASP8, CASP3, CASP10, CASP9, BCL2
368.1CASP10, CASP9, CASP3, CASP8, WNT7A, BCL2
378.1BID, BCL2, CASP8, CASP3, CASP9
38
Show member pathways
7.8BCL2, CASP3, CASP9, BID, CASP8, APAF1
39
Show member pathways
7.6CASP8, BID, CASP9, CASP10, CASP3, BCL2
407.6CASP9, BID, CASP3, CASP10, CASP8, BCL2
41
Show member pathways
FAS pathway and Stress induction of HSP regulation37
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis37
7.6BID, APAF1, BCL2, CASP8, CASP3, CASP9
42
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
7.6CASP8, CASP10, CASP3, BCL2, APAF1, BID
437.6APAF1, BCL2, CASP10, CASP9, BID, CASP3
44
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
7.6CASP3, BID, CASP9, CASP10, CASP8, BCL2
457.6CASP8, CASP3, CASP10, APAF1, BCL2, CASP9
46
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
7.6BID, CASP9, CASP10, BCL2, CASP3, CASP8
47
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
7.6APAF1, BCL2, CASP8, CASP3, CASP10, CASP9
48
Show member pathways
7.6BCL2, CASP8, CASP3, CASP10, CASP9, BID
497.5CASP9, CASP8, GLI3, WNT7A, BCL2, CASP3
50
Show member pathways
6.9CASP9, CASP10, CASP3, CASP8, BCL2, COL9A1

Compounds for genes affiliated with Talipes Equinovarus

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Compounds related to Talipes Equinovarus according to GeneCards/GeneDecks:

(show top 50)    (show all 158)
idCompoundScoreTop Affiliating Genes
1d-api449.4CASP9, CASP3, CASP8
2z-dqmd-fmk61 2810.4CASP8, CASP3, CASP10, CASP9
3z-devd-fmk61 2810.4CASP8, CASP9, CASP3, CASP10
4az 10417808619.4CASP8, CASP3, CASP10, CASP9
52-chlorodeoxyadenosine449.2CASP9, APAF1, BCL2, CASP8
6cardiolipin44 1110.1CASP9, BID, CFH, CASP8
7oridonin449.1CASP9, BCL2, CASP3
8bongkrekic acid449.0BCL2, CASP8, CASP9, CASP3
9beta-lapachone449.0CASP3, BCL2, CASP9
10parthenolide44 210.0BID, CASP9, CASP3, CASP8
11shikonin449.0CASP9, CASP3, CASP8, BCL2
12betulinic acid44 2810.0CASP9, BCL2, CASP8, CASP3
13vitamin e succinate448.9CASP9, CASP3, CASP8, BCL2
14sulindac sulfide448.9BCL2, CASP8, CASP3, CASP9
15triptolide448.9BCL2, CASP3, CASP9, CASP8
16indole-3-carbinol448.9CASP8, CASP9, BCL2, CASP3
17dutp448.8CASP9, CASP3, CASP8, BCL2
18sulforaphane448.8CASP9, CASP8, CASP3, BCL2
19z-vad-fmk44 619.8CASP9, CASP8, BCL2, CASP3, CASP10
20depsipeptide448.8BCL2, CASP8, CASP9, CASP3
212-methoxyestradiol44 61 2410.7CASP8, BCL2, BID, CASP9
22celecoxib44 61 28 50 24 1113.7CASP8, CASP9, BCL2, APAF1, CASP3
23n-(4-hydroxyphenyl)retinamide448.7CASP9, CASP3, CASP8, BCL2
24lactacystin448.7CASP3, CASP9, CASP8, BCL2, APAF1
25fludarabine44 50 1110.6BID, CASP8, BCL2, APAF1
264,6-diamidino-2-phenylindole448.5BCL2, CASP8, CASP3, CASP9, BID
27sanguinarine448.5BCL2, CASP8, CASP3, CASP9, BID
28phenethyl isothiocyanate2 449.5CASP9, CASP3, CASP8, BCL2, BID
29cd 437448.5BID, BCL2, CASP3, CASP8, CASP9
30suberoylanilide hydroxamic acid448.5BCL2, CASP8, CASP3, CASP9, BID
31flavopiridol44 119.4CASP9, CASP8, BCL2, CASP3, BID
32gemcitabine44 50 1110.4CASP3, CASP9, CASP8, BCL2, BID
33sp 60012544 619.4CASP8, CASP3, BCL2, BID, CASP9
34mg 13244 619.3CASP9, CASP8, BID, BCL2, CASP3
35noxa448.3CASP8, APAF1, CASP3, CASP9, BID, BCL2
36bortezomib44 50 1110.3CASP3, CASP8, BCL2, APAF1, CASP9, BID
37adpribose448.3BID, CASP3, BCL2, APAF1, CASP9, CASP8
38resveratrol44 61 24 1111.2BID, CASP9, CASP3, CASP8, BCL2, APAF1
39camptothecin44 61 1110.2CASP8, APAF1, BCL2, CASP3, CASP9, BID
40phosphatidylserine44 28 1110.2CASP3, CASP8, BID, CASP9, BCL2, APAF1
41etoposide44 50 61 1111.2APAF1, BCL2, CASP3, CASP9, BID, CASP8
42docetaxel44 50 61 1111.1BID, CASP3, CASP9, CASP8, BCL2, NAT2
43curcumin448.1CASP8, BID, CASP9, CASP3, BCL2, NAT1
44doxorubicin44 50 1110.0BCL2, CASP3, CASP8, CASP9, BID, APAF1
45imatinib44 50 119.9CASP8, CASP3, BID, BCL2, COL1A1
46dexamethasone44 50 28 1110.9APAF1, CASP9, SLC26A2, CASP8, CFH, NAT2
47ceramide447.8BID, CASP9, CASP3, BCL2, CASP8
48paclitaxel44 50 119.8BID, APAF1, NAT1, BCL2, CASP8, CASP3
49cisplatin44 50 61 1110.4CASP8, BCL2, CASP3, CASP10, APAF1, BID
50cysteine447.0CFH, CASP9, SLC26A2, BID, CASP10, CASP3

GO Terms for genes affiliated with Talipes Equinovarus

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Cellular components related to Talipes Equinovarus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptosomeGO:04329310.0CASP9, APAF1
2CD95 death-inducing signaling complexGO:0312659.9CASP10, CASP8
3ripoptosomeGO:0973429.8CASP10, CASP8
4endoplasmic reticulum lumenGO:0057889.5WNT7A, COL1A1, COL9A1
5mitochondrial outer membraneGO:0057418.6BID, CASP8, BCL2
6cytosolGO:0058296.6GLI3, BID, CASP9, CASP10, CASP3, CASP8
7nucleusGO:0056346.4RBM10, FHL1, BCL2, CASP3, APAF1, HOXD13

Biological processes related to Talipes Equinovarus according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1proximal/distal pattern formationGO:00995410.2GLI3, HOXD10
2anterior/posterior pattern specificationGO:00995210.2GLI3, HOXD13, HOXD10
3response to cobalt ionGO:03202510.1CASP8, CASP9
4signal transduction in response to DNA damageGO:0427709.9BID, CASP9
5platelet formationGO:0302209.9CASP3, CASP9
6xenobiotic metabolic processGO:0068059.9SLC26A2, NAT1, NAT2
7negative regulation of G1/S transition of mitotic cell cycleGO:20001349.8BCL2, FHL1
8activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cGO:0086359.8CASP9, CASP3, APAF1
9activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.7BID, CASP8, APAF1
10apoptotic signaling pathwayGO:0971909.6CASP8, CASP3, CASP10
11intrinsic apoptotic signaling pathway in response to oxidative stressGO:0086319.6CASP3, BCL2
12B cell homeostasisGO:0017829.6BCL2, CASP3
13extracellular matrix disassemblyGO:0226179.6CASP3, COL9A1, COL1A1
14execution phase of apoptosisGO:0971949.5CASP3, CASP8
15regulation of apoptotic processGO:0429819.5CASP9, CASP10, CASP3, APAF1
16glial cell apoptotic processGO:0343499.5CASP3, CASP9, BID
17heart developmentGO:0075079.5CASP8, CASP3, GLI3
18T cell homeostasisGO:0430299.4CASP3, BCL2
19response to tumor necrosis factorGO:0346129.4CASP8, CASP3
20apoptotic DNA fragmentationGO:0063099.4CASP3, APAF1
21embryonic digit morphogenesisGO:0427339.3HOXD12, HOXD13, WNT7A, GLI3
22positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:19007409.3BCL2, CASP8, BID
23skeletal system developmentGO:0015019.3COL1A1, HOXD13, HOXD12
24positive regulation of apoptotic processGO:0430659.2APAF1, CASP3, CASP9, BID
25release of cytochrome c from mitochondriaGO:0018369.2BID, CASP3, BCL2
26cellular response to DNA damage stimulusGO:0069749.1BCL2, CASP3, CASP9
27neuron apoptotic processGO:0514029.0BID, CASP3, BCL2, APAF1
28response to estradiolGO:0323558.9WNT7A, COL1A1, CASP8, CASP9, BID
29innate immune responseGO:0450878.8CFH, BCL2, CASP8, CASP10, CASP9
30negative regulation of apoptotic processGO:0430668.8GLI3, CASP3, BCL2, WNT7A
31extrinsic apoptotic signaling pathway via death domain receptorsGO:0086258.8BCL2, CASP8, CASP3, BID
32intrinsic apoptotic signaling pathwayGO:0971938.2BID, CASP9, CASP3, CASP8, BCL2, APAF1
33apoptotic processGO:0069158.0APAF1, BCL2, CASP8, CASP3, CASP10, CASP9

Molecular functions related to Talipes Equinovarus according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:09719910.0CASP8, CASP10
2arylamine N-acetyltransferase activityGO:00406010.0NAT2, NAT1
3death effector domain bindingGO:0358779.9CASP10, CASP8
4cysteine-type endopeptidase activity involved in apoptotic processGO:0971539.4CASP8, CASP3
5cysteine-type endopeptidase activityGO:0041979.2CASP9, CASP10, CASP3, CASP8
6peptidase activityGO:0082338.9CASP9, CASP3, CASP8
7identical protein bindingGO:0428028.9RBM10, BCL2, COL1A1, APAF1
8ubiquitin protein ligase bindingGO:0316258.8BCL2, CASP8, CASP10, BID
9protein bindingGO:0055156.0BCL2, COL1A1, FHL1, APAF1, CFH, CASP8

Products for genes affiliated with Talipes Equinovarus

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Sources for Talipes Equinovarus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet