CTEV
MCID: TLP001
MIFTS: 55

Talipes Equinovarus (CTEV) malady

Rare diseases category

Summaries for Talipes Equinovarus

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Talipes equinovarus is a congenital (present from birth) condition where the foot turns inward and downward. the cause of this condition is not known, although it may be passed down through families in some cases. this condition occurs in about 1 out of every 1,000 births. treatment may involve moving the foot into the correct position and using a cast to keep it there. this process is done in small increments over a period of time. in severe cases, surgery may be needed.  <span style="font-size: 16px;"> &lt;span style="font-size: 13px;"&gt; body {background-color: #ffffff; font-family: "times new roman"; font-size: 12pt;} &lt;/span&gt; </span> ]]> last updated: 2/27/2014

MalaCards: Talipes Equinovarus, also known as congenital talipes equinovarus, is related to clubfoot and syndactyly. An important gene associated with Talipes Equinovarus is HOXD13 (homeobox D13), and among its related pathways are EGFR Signaling Pathway and LT-BetaR Pathway. The compounds d-api and z-dqmd-fmk have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are taste/olfaction and pigmentation.

Wikipedia:66 A club foot or clubfoot, also called congenital talipes equinovarus (CTEV), is a congenital deformity... more...

Aliases & Classifications for Talipes Equinovarus

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44NIH Rare Diseases, 23GTR, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

talipes equinovarus 44 23
congenital talipes equinovarus 44
clubfoot 44
talipes 44
ctev 44


External Ids:

ICD1026 Q66.0

Related Diseases for Talipes Equinovarus

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18GeneCards, 19GeneDecks
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Diseases related to Talipes Equinovarus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 239)
idRelated DiseaseScoreTop Affiliating Genes
1clubfoot31.2HOXD10, COL9A1, SLC26A2, GLI3, HOXD13
2syndactyly29.9HOXD12, HOXD13, GLI3
3multiple epiphyseal dysplasia29.9COL9A1, SLC26A2
4tarp syndrome10.5
5myotonic dystrophy10.4
6clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly10.4
7myotonic dystrophy type 210.4
8congenital myotonic dystrophy10.4
9myelomeningocele10.4
10adducted thumb and clubfoot syndrome10.3
11familial clubfoot due to 17q23.1q23.2 microduplication10.2
12eunuchism10.2
13compartment syndrome10.2
14dystonia10.2
15spina bifida10.2
16kabuki syndrome10.2
17camptodactyly joint contractures and facial skeletal dysplasia10.2
18crane-heise syndrome10.2
19fertile eunuch syndrome10.2
20frontonasal dysplasia acromelic10.2
21metatarsus adductus10.2
22vertical talus, congenital10.2
23spasticity10.2
24pseudohypoaldosteronism type ii10.2
25richieri costa pereira syndrome10.2
26short stature robin sequence cleft mandible hand anomalies clubfoot10.2
27familial clubfoot due to 5q31 microdeletion10.2
28intellectual deficit unusual facies talipes hand anomalies10.2
29brachydactyly-syndactyly syndrome10.1HOXD13
30myocardial infarction10.1CFH
31esophageal atresia coloboma talipes10.1
32short stature talipes natal teeth10.1
33xeroderma talipes enamel defects10.1
34pseudoachondroplasia10.1SLC26A2, COL9A1
35polydactyly10.1HOXD12, HOXD13, GLI3
36cleft palate10.1
37ehlers-danlos syndrome10.1
38moebius syndrome10.1
39multiple epiphyseal dysplasia 410.1
40pitx1-related congenital clubfoot10.1
41ehlers-danlos syndrome, musculocontractural type 210.1
42otosclerosis10.1COL1A1, SLC26A2
43lumbar disc disease10.1COL1A1
44autoimmune lymphoproliferative syndrome10.0CASP8, CASP10
45transitional cell carcinoma10.0NAT2, NAT1, APAF1
46cholangiocarcinoma10.0CASP9, NAT1, NAT2
47systemic scleroderma10.0COL1A1
48cataract10.0CASP9, NAT1, NAT2
49cerebral hypoxia10.0CASP9, CASP3
50schwartz jampel syndrome type 110.0

Graphical network of the top 20 diseases related to Talipes Equinovarus:



Diseases related to talipes equinovarus

Symptoms for Talipes Equinovarus

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Drugs & Therapeutics for Talipes Equinovarus

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Talipes Equinovarus

Drug clinical trials:

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Search NIH Clinical Center for Talipes Equinovarus

Search CenterWatch for Talipes Equinovarus

Genetic Tests for Talipes Equinovarus

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23GTR
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Genetic tests related to Talipes Equinovarus:

id Genetic test Affiliating Genes
1 Talipes Equinovarus23

Anatomical Context for Talipes Equinovarus

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34MalaCards
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MalaCards organs/tissues related to Talipes Equinovarus:

34
Bone

Animal Models for Talipes Equinovarus or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Talipes Equinovarus:

38 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.3GLI3, CASP9, CASP3
2MP:00011868.4CFH, COL1A1, BCL2, CASP3, GLI3
3MP:00053778.2APAF1, WNT7A, COL1A1, COL9A1, BCL2, CASP3
4MP:00053678.1HOXD10, HOXD13, CFH, BCL2, CASP8, CASP3
5MP:00053828.0APAF1, COL1A1, BCL2, CASP3, CASP9, GLI3
6MP:00053718.0HOXD10, HOXD12, HOXD13, APAF1, WNT7A, COL1A1
7MP:00107717.8HOXD13, WNT7A, COL1A1, BCL2, CASP8, CASP3
8MP:00053807.5HOXD12, HOXD13, APAF1, NAT1, WNT7A, COL1A1
9MP:00053817.5HOXD12, HOXD13, APAF1, COL1A1, BCL2, CASP3
10MP:00053797.5HOXD13, APAF1, COL1A1, BCL2, CASP8, CASP3
11MP:00053907.4APAF1, HOXD13, HOXD12, HOXD10, WNT7A, COL1A1
12MP:00053887.4APAF1, COL1A1, BCL2, CASP8, CASP3, CASP9
13MP:00053867.1HOXD10, APAF1, WNT7A, FHL1, COL1A1, BCL2
14MP:00053787.1HOXD13, FHL1, COL1A1, BCL2, CASP8, CASP3
15MP:00053697.0HOXD10, HOXD12, HOXD13, COL1A1, BCL2, CASP8
16MP:00053846.9BCL2, COL1A1, APAF1, HOXD10, CASP8, CASP3
17MP:00053876.8CFH, APAF1, COL1A1, COL9A1, BCL2, CASP8
18MP:00053896.6HOXD10, HOXD12, HOXD13, APAF1, NAT2, NAT1
19MP:00053916.6HOXD13, CFH, APAF1, NAT1, WNT7A, FHL1
20MP:00053856.6CFH, APAF1, WNT7A, FHL1, COL1A1, BCL2
21MP:00053766.5CFH, NAT2, NAT1, FHL1, COL1A1, COL9A1
22MP:00107685.4WNT7A, APAF1, CFH, HOXD13, HOXD12, HOXD10
23MP:00036315.1GLI3, HOXD10, HOXD12, HOXD13, CFH, APAF1

Publications for Talipes Equinovarus

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53PubMed
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Articles related to Talipes Equinovarus:

(show top 50)    (show all 208)
idTitleAuthorsYear
1
Osteopathic manipulative treatment of congenital talipes equinovarus: A case report. (24411143)
2014
2
Congenital idiopathic talipes equinovarus: an evaluation in infants treated by the Ponseti method. (24142617)
2013
3
Possible role of GLI3 gene in the pathogenesis of idiopathic congenital talipes equinovarus]. (22678783)
2012
4
The inter-relationship of clinical parameters in congenital talipes equinovarus: relevance to pathological anatomy and clinical classification. (23450265)
2012
5
Comparison of Ponseti versus surgical treatment in congenital talipes equinovarus. (21680202)
2011
6
Management of congenital talipes equinovarus using the Ponseti method: a systematic review. (21911524)
2011
7
The effect of neuromuscular electrical stimulation on congenital talipes equinovarus following correction with the Ponseti method: a pilot study. (20581693)
2010
8
Congenital talipes equinovarus associated with myotonic dystrophy type 2. (20665517)
2010
9
A new flexible brace used in the Ponseti treatment of talipes equinovarus. (19471177)
2008
10
Apoptotic gene analysis in idiopathic talipes equinovarus (clubfoot). (17534194)
2007
11
Histologic and histochemical analysis of muscle specimens in idiopathic talipes equinovarus. (16439910)
2006
12
Early results of a physiotherapist-delivered Ponseti service for the management of idiopathic congenital talipes equinovarus foot deformity. (16877611)
2006
13
Wound problems in surgery for talipes equinovarus. (16286376)
2005
14
Variation in CASP10 gene is associated with idiopathic talipes equinovarus. (16199938)
2005
15
Radiographic assessment of congenital talipes equinovarus: strapping versus forced dorsiflexion. (16365488)
2005
16
Talipes equinovarus in Western Australia. (12675786)
2003
17
Peritalar release in the treatment of congenital talipes equinovarus clubfoot. (12056243)
2001
18
Evaluation of foot bimalleolar angle in the management of congenital talipes equinovarus. (11176354)
2001
19
Resistant talipes equinovarus associated with congenital constriction band syndrome. (10739290)
2000
20
The functional outcome of staged surgery for the correction of talipes equinovarus. (10912611)
2000
21
Somatosensory evoked potentials as a means of assessing neurological abnormality in congenital talipes equinovarus. (10981930)
2000
22
Epidemiology and genetic theories in the etiology of congenital talipes equinovarus. (10431636)
1999
23
MRI multiplanar reconstruction in the assessment of congenital talipes equinovarus. (10199904)
1999
24
Congenital talipes equinovarus in spina bifida: treatment and results. (8906652)
1996
25
Intraoperative ultrasound for evaluation of reduction in congenital talipes equinovarus. (7719835)
1995
26
Relationship between acquired spastic talipes equinovarus and dystonia musculorum deformans. (8416347)
1993
27
Seasonal variation in the incidence of congenital talipes equinovarus. (2071648)
1991
28
Risk indicators for talipes equinovarus in Washington State, 1987-1989. (1912045)
1991
29
Assessment in congenital talipes equinovarus. (2210529)
1990
30
Congenital talipes equinovarus. (2391207)
1990
31
Results of surgical treatment of talipes equinovarus congenita. (2805484)
1989
32
Posteromedial release for idiopathic talipes equinovarus. A long-term follow-up study. (2706856)
1989
33
Congenital talipes equinovarus. (3647366)
1987
34
Distal calcaneal osteotomy in resistant talipes equinovarus. (4017338)
1985
35
Prevalence and management of congenital club-feet (talipes equinovarus) in Zambia. (4006815)
1985
36
A higher incidence of congenital structural talipes equinovarus in gypsies. (6840781)
1983
37
Talipes equinovarus. (6554645)
1983
38
Surgical management of resistant congenital talipes equinovarus deformities. (7085691)
1982
39
HLA and clubfoot (idiopathic talipes equinovarus). (7071822)
1982
40
Early Dwyer operation in talipes equinovarus. (7471561)
1981
41
Management of congenital talipes equinovarus. (4809545)
1974
42
Practical considerations in the early treatment of congenital talipes equinovarus. (5012585)
1972
43
Congenital talipes equinovarus--fifteen years of surgical treatment. (5804493)
1969
44
Severe congenital talipes equinovarus. (5909063)
1966
45
THE GENETICS OF TALIPES EQUINOVARUS. (14133340)
1964
46
Recurring congenital talipes equinovarus. (13806063)
1960
47
Congenital talipes equinovarus. (13442744)
1957
48
Talipes equinovarus. (18131349)
1949
49
Symmetrical talipes equinovarus in identical twins. (18115536)
1949
50
A new and original development in the treatment of talipes equinovarus. (18879761)
1948

Variations for Talipes Equinovarus

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Talipes Equinovarus:

1
id Gene Name Type Significance SNP ID Assembly Location
1PITX1NM_002653.4(PITX1): c.388G> A (p.Glu130Lys)single nucleotide variantPathogenicrs121909109GRCh37Chr 5, 134366980: 134366980

Expression for genes affiliated with Talipes Equinovarus

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Talipes Equinovarus

Search GEO for disease gene expression data for Talipes Equinovarus.

Pathways for genes affiliated with Talipes Equinovarus

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Sources:
51PathCards, 58SinoBiological, 54QIAGEN, 61Thomson Reuters, 39NCBI BioSystems Database, 56Reactome, 52PharmGKB, 62Tocris Bioscience, 31KEGG, 55R&D Systems, 5Cell Signaling Technology
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Pathways related to Talipes Equinovarus according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CASP10, CASP9, CASP3
2
Show member pathways
Apoptosis and survival Lymphotoxin beta receptor signaling61
9.4CASP3, CASP9, APAF1
39.4CASP3, APAF1, CASP9
4
Show member pathways
9.4APAF1, CASP3, CASP9
5
Show member pathways
9.4CASP3, APAF1, CASP9
6
Show member pathways
9.4APAF1, CASP3, CASP9
7
Show member pathways
Catalytic cycle of mammalian FMOs39
9.2NAT2, BCL2, NAT1
89.2CASP9, CASP3, CASP8
9
Show member pathways
9.0CASP3, CASP9, CASP8, CASP10
10
Show member pathways
9.0CASP10, CASP9, CASP3, CASP8
119.0CASP9, CASP10, CASP3, CASP8
129.0APAF1, CASP8, CASP3, CASP9
138.9BID, CASP8, BCL2
148.9APAF1, CASP10, BID, BCL2
15
Show member pathways
TRAIL signaling pathway39
8.8BID, CASP8, CASP3, CASP10
168.8CASP3, BCL2, CASP9, APAF1
17
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
8.8BCL2, CASP9, CASP3, APAF1
18
Show member pathways
8.7CASP9, CASP8, CASP3, BID
19
Show member pathways
8.6CASP9, CASP3, CASP8, BCL2
20
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
8.6CASP3, CASP8, BCL2, CASP9
218.4APAF1, CASP3, BID, CASP8, CASP9
22
Show member pathways
Alzheimers Disease39
8.4CASP8, CASP3, APAF1, BID, CASP9
23
Show member pathways
8.4APAF1, CASP3, CASP9, BID, CASP8
24
Show member pathways
8.4CASP9, CASP8, BID, APAF1, CASP3
25
Show member pathways
8.4CASP8, BID, CASP9, APAF1, CASP3
26
Show member pathways
DNA damage response39
8.4APAF1, CASP9, BID, CASP8, CASP3
27
Show member pathways
8.4CASP9, BCL2, CASP10, CASP3, CASP8
28
Show member pathways
8.4CASP10, CASP8, BCL2, CASP3, CASP9
29
Show member pathways
8.4CASP3, CASP10, BCL2, CASP9, CASP8
30
Show member pathways
8.4BCL2, CASP9, CASP10, CASP8, CASP3
31
Show member pathways
8.3BID, CASP8, BCL2, APAF1, CASP9
32
Show member pathways
8.3CASP9, CASP10, BCL2, CASP3, BID
33
Show member pathways
8.2BID, CASP9, CASP3, CASP10, APAF1, CASP8
34
Show member pathways
Amyotrophic lateral sclerosis (ALS)39
8.2BID, APAF1, CASP9, BCL2, CASP3
35
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.1APAF1, CASP8, CASP3, CASP10, CASP9, BCL2
368.1CASP10, CASP9, CASP3, CASP8, WNT7A, BCL2
378.1BID, BCL2, CASP8, CASP3, CASP9
38
Show member pathways
7.8BCL2, CASP3, CASP9, BID, CASP8, APAF1
39
Show member pathways
7.6CASP8, BID, CASP9, CASP10, CASP3, BCL2
407.6CASP9, BID, CASP3, CASP10, CASP8, BCL2
41
Show member pathways
FAS pathway and Stress induction of HSP regulation39
Apoptosis and survival FAS signaling cascades61
Caspase cascade in apoptosis39
7.6BID, APAF1, BCL2, CASP8, CASP3, CASP9
42
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
7.6CASP8, CASP10, CASP3, BCL2, APAF1, BID
437.6APAF1, BCL2, CASP10, CASP9, BID, CASP3
44
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways61
7.6CASP3, BID, CASP9, CASP10, CASP8, BCL2
457.6CASP8, CASP3, CASP10, APAF1, BCL2, CASP9
46
Show member pathways
Proteasome Degradation39
Immune response Antigen presentation by MHC class I61
7.6BID, CASP9, CASP10, BCL2, CASP3, CASP8
47
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
7.6APAF1, BCL2, CASP8, CASP3, CASP10, CASP9
48
Show member pathways
7.6BCL2, CASP8, CASP3, CASP10, CASP9, BID
497.5CASP9, CASP8, GLI3, WNT7A, BCL2, CASP3
50
Show member pathways
6.9CASP9, CASP10, CASP3, CASP8, BCL2, COL9A1

Compounds for genes affiliated with Talipes Equinovarus

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Sources:
46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 3BitterDB, 25HMDB, 52PharmGKB
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Compounds related to Talipes Equinovarus according to GeneCards/GeneDecks:

(show top 50)    (show all 158)
idCompoundScoreTop Affiliating Genes
1d-api469.4CASP9, CASP3, CASP8
2z-dqmd-fmk62 3010.4CASP8, CASP3, CASP10, CASP9
3z-devd-fmk62 3010.4CASP8, CASP9, CASP3, CASP10
4az 10417808629.4CASP8, CASP3, CASP10, CASP9
52-chlorodeoxyadenosine469.2CASP9, APAF1, BCL2, CASP8
6cardiolipin46 1210.1CASP9, BID, CFH, CASP8
7oridonin469.1CASP9, BCL2, CASP3
8bongkrekic acid469.0BCL2, CASP8, CASP9, CASP3
9beta-lapachone469.0CASP3, BCL2, CASP9
10parthenolide46 310.0BID, CASP9, CASP3, CASP8
11shikonin469.0CASP9, CASP3, CASP8, BCL2
12betulinic acid46 3010.0CASP9, BCL2, CASP8, CASP3
13vitamin e succinate468.9CASP9, CASP3, CASP8, BCL2
14sulindac sulfide468.9BCL2, CASP8, CASP3, CASP9
15triptolide468.9BCL2, CASP3, CASP9, CASP8
16indole-3-carbinol468.9CASP8, CASP9, BCL2, CASP3
17dutp468.8CASP9, CASP3, CASP8, BCL2
18sulforaphane468.8CASP9, CASP8, CASP3, BCL2
19z-vad-fmk46 629.8CASP9, CASP8, BCL2, CASP3, CASP10
20depsipeptide468.8BCL2, CASP8, CASP9, CASP3
212-methoxyestradiol46 62 2510.7CASP8, BCL2, BID, CASP9
22celecoxib46 62 30 52 25 1213.7CASP8, CASP9, BCL2, APAF1, CASP3
23n-(4-hydroxyphenyl)retinamide468.7CASP9, CASP3, CASP8, BCL2
24lactacystin468.7CASP3, CASP9, CASP8, BCL2, APAF1
25fludarabine46 52 1210.6BID, CASP8, BCL2, APAF1
264,6-diamidino-2-phenylindole468.5BCL2, CASP8, CASP3, CASP9, BID
27sanguinarine468.5BCL2, CASP8, CASP3, CASP9, BID
28phenethyl isothiocyanate3 469.5CASP9, CASP3, CASP8, BCL2, BID
29cd 437468.5BID, BCL2, CASP3, CASP8, CASP9
30suberoylanilide hydroxamic acid468.5BCL2, CASP8, CASP3, CASP9, BID
31flavopiridol46 129.4CASP9, CASP8, BCL2, CASP3, BID
32gemcitabine46 52 1210.4CASP3, CASP9, CASP8, BCL2, BID
33sp 60012546 629.4CASP8, CASP3, BCL2, BID, CASP9
34mg 13246 629.3CASP9, CASP8, BID, BCL2, CASP3
35noxa468.3CASP8, APAF1, CASP3, CASP9, BID, BCL2
36bortezomib46 52 1210.3CASP3, CASP8, BCL2, APAF1, CASP9, BID
37adpribose468.3BID, CASP3, BCL2, APAF1, CASP9, CASP8
38resveratrol46 62 25 1211.2BID, CASP9, CASP3, CASP8, BCL2, APAF1
39camptothecin46 62 1210.2CASP8, APAF1, BCL2, CASP3, CASP9, BID
40phosphatidylserine46 30 1210.2CASP3, CASP8, BID, CASP9, BCL2, APAF1
41etoposide46 52 62 1211.2APAF1, BCL2, CASP3, CASP9, BID, CASP8
42docetaxel46 52 62 1211.1BID, CASP3, CASP9, CASP8, BCL2, NAT2
43curcumin468.1CASP8, BID, CASP9, CASP3, BCL2, NAT1
44doxorubicin46 52 1210.0BCL2, CASP3, CASP8, CASP9, BID, APAF1
45imatinib46 52 129.9CASP8, CASP3, BID, BCL2, COL1A1
46dexamethasone46 52 30 1210.9APAF1, CASP9, SLC26A2, CASP8, CFH, NAT2
47ceramide467.8BID, CASP9, CASP3, BCL2, CASP8
48paclitaxel46 52 129.8BID, APAF1, NAT1, BCL2, CASP8, CASP3
49cisplatin46 52 62 1210.4CASP8, BCL2, CASP3, CASP10, APAF1, BID
50cysteine467.0CFH, CASP9, SLC26A2, BID, CASP10, CASP3

GO Terms for genes affiliated with Talipes Equinovarus

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Sources:
17Gene Ontology
See all sources

Cellular components related to Talipes Equinovarus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptosomeGO:04329310.0APAF1, CASP9
2ripoptosomeGO:0973429.9CASP8, CASP10
3CD95 death-inducing signaling complexGO:0312659.8CASP8, CASP10
4endoplasmic reticulum lumenGO:0057889.5COL9A1, COL1A1, WNT7A
5mitochondrial outer membraneGO:0057418.6BID, CASP8, BCL2
6cytosolGO:0058296.6GLI3, APAF1, NAT2, NAT1, FHL1, BCL2
7nucleusGO:0056346.4HOXD10, HOXD12, HOXD13, APAF1, FHL1, BCL2

Biological processes related to Talipes Equinovarus according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1proximal/distal pattern formationGO:00995410.2GLI3, HOXD10
2anterior/posterior pattern specificationGO:00995210.2GLI3, HOXD13, HOXD10
3response to cobalt ionGO:03202510.1CASP8, CASP9
4signal transduction in response to DNA damageGO:0427709.9BID, CASP9
5platelet formationGO:0302209.9CASP3, CASP9
6xenobiotic metabolic processGO:0068059.9SLC26A2, NAT1, NAT2
7negative regulation of G1/S transition of mitotic cell cycleGO:20001349.8BCL2, FHL1
8activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cGO:0086359.8CASP9, CASP3, APAF1
9activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.7BID, CASP8, APAF1
10apoptotic signaling pathwayGO:0971909.6CASP8, CASP3, CASP10
11intrinsic apoptotic signaling pathway in response to oxidative stressGO:0086319.6CASP3, BCL2
12B cell homeostasisGO:0017829.6BCL2, CASP3
13extracellular matrix disassemblyGO:0226179.6CASP3, COL9A1, COL1A1
14execution phase of apoptosisGO:0971949.5CASP3, CASP8
15regulation of apoptotic processGO:0429819.5CASP9, CASP10, CASP3, APAF1
16glial cell apoptotic processGO:0343499.5CASP3, CASP9, BID
17heart developmentGO:0075079.5CASP8, CASP3, GLI3
18T cell homeostasisGO:0430299.4CASP3, BCL2
19response to tumor necrosis factorGO:0346129.4CASP8, CASP3
20apoptotic DNA fragmentationGO:0063099.4CASP3, APAF1
21embryonic digit morphogenesisGO:0427339.3HOXD12, HOXD13, WNT7A, GLI3
22positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:19007409.3BCL2, CASP8, BID
23skeletal system developmentGO:0015019.3COL1A1, HOXD13, HOXD12
24positive regulation of apoptotic processGO:0430659.2APAF1, CASP3, CASP9, BID
25release of cytochrome c from mitochondriaGO:0018369.2BID, CASP3, BCL2
26cellular response to DNA damage stimulusGO:0069749.1BCL2, CASP3, CASP9
27neuron apoptotic processGO:0514029.0BID, CASP3, BCL2, APAF1
28response to estradiolGO:0323558.9WNT7A, COL1A1, CASP8, CASP9, BID
29innate immune responseGO:0450878.8CFH, BCL2, CASP8, CASP10, CASP9
30negative regulation of apoptotic processGO:0430668.8GLI3, CASP3, BCL2, WNT7A
31extrinsic apoptotic signaling pathway via death domain receptorsGO:0086258.8BCL2, CASP8, CASP3, BID
32intrinsic apoptotic signaling pathwayGO:0971938.2BID, CASP9, CASP3, CASP8, BCL2, APAF1
33apoptotic processGO:0069158.0APAF1, BCL2, CASP8, CASP3, CASP10, CASP9

Molecular functions related to Talipes Equinovarus according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:09719910.0CASP8, CASP10
2arylamine N-acetyltransferase activityGO:00406010.0NAT2, NAT1
3death effector domain bindingGO:0358779.9CASP10, CASP8
4cysteine-type endopeptidase activity involved in apoptotic processGO:0971539.4CASP8, CASP3
5cysteine-type endopeptidase activityGO:0041979.2CASP9, CASP10, CASP3, CASP8
6peptidase activityGO:0082338.9CASP9, CASP3, CASP8
7identical protein bindingGO:0428028.9RBM10, BCL2, COL1A1, APAF1
8ubiquitin protein ligase bindingGO:0316258.8BCL2, CASP8, CASP10, BID
9protein bindingGO:0055156.0BCL2, COL1A1, FHL1, APAF1, CFH, CASP8

Products for genes affiliated with Talipes Equinovarus

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Sources for Talipes Equinovarus

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet