CTEV
MCID: TLP001
MIFTS: 41

Talipes Equinovarus (CTEV) malady

Summaries for Talipes Equinovarus

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Talipes equinovarus is a congenital (present from birth) condition where the foot turns inward and downward. the cause of this condition is not known, although it may be passed down through families in some cases. this condition occurs in about 1 out of every 1,000 births. treatment may involve moving the foot into the correct position and using a cast to keep it there. this process is done in small increments over a period of time. in severe cases, surgery may be needed.  <span style="font-size: 16px;"> &lt;span style="font-size: 13px;"&gt; body {background-color: #ffffff; font-family: "times new roman"; font-size: 12pt;} &lt;/span&gt; </span> ]]> last updated: 2/27/2014

MalaCards: Talipes Equinovarus, also known as congenital talipes equinovarus, is related to clubfoot and cleft palate. An important gene associated with Talipes Equinovarus is HOXD13 (homeobox D13), and among its related pathways are Regulation by c-FLIP and FasL/ CD95L signaling. The compounds n-hydroxyarylamine and nitroarenes have been mentioned in the context of this disorder. Related mouse phenotypes are hearing/vestibular/ear and renal/urinary system.

Wikipedia:63 A club foot or clubfoot, also called congenital talipes equinovarus (CTEV), is a congenital deformity... more...

Aliases & Classifications for Talipes Equinovarus

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42NIH Rare Diseases, 22GTR, 25ICD10
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Classifications:



Aliases & Descriptions:

talipes equinovarus 42 22
congenital talipes equinovarus 42
clubfoot 42
talipes 42
ctev 42


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ICD1025 Q66.0

Related Diseases for Talipes Equinovarus

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17GeneCards, 18GeneDecks
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Diseases related to Talipes Equinovarus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 228)
idRelated DiseaseScoreTop Affiliating Genes
1clubfoot31.1COL9A1, HOXD10, SLC26A2, HOXD13, GLI3, PITX1
2cleft palate30.0NAT1
3osteoarthritis29.8COL1A1, COL9A1
4myopathy29.8FHL1
5syndactyly29.7HOXD13, GLI3, HOXD12
6tarp syndrome10.5
7myotonic dystrophy10.4
8clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly10.3
9myotonic dystrophy type 210.3
10adducted thumb and clubfoot syndrome10.3
11familial clubfoot due to 17q23.1q23.2 microduplication10.2
12eunuchism10.2
13aortic valve stenosis10.2
14compartment syndrome10.2
15dystonia musculorum deformans10.2
16spina bifida10.2
17kabuki syndrome10.2
18camptodactyly joint contractures and facial skeletal dysplasia10.2
19crane-heise syndrome10.2
20frontonasal dysplasia acromelic10.2
21pseudohypoaldosteronism type ii10.1
22richieri costa pereira syndrome10.1
23short stature robin sequence cleft mandible hand anomalies clubfoot10.1
24familial clubfoot due to 5q31 microdeletion10.1
25intellectual deficit unusual facies talipes hand anomalies10.1
26esophageal atresia coloboma talipes10.0
27short stature talipes natal teeth10.0
28xeroderma talipes enamel defects10.0
29spondyloepiphyseal dysplasia with congenital joint dislocations10.0
30ehlers-danlos syndrome10.0
31atelosteogenesis type 210.0
32arthrogryposis multiplex congenita distal type 110.0
33pitx1-related congenital clubfoot10.0
34ehlers-danlos syndrome, musculocontractural type 210.0
35brachydactyly-syndactyly syndrome10.0HOXD13
36laryngeal squamous cell carcinoma10.0NAT2
37brachydactyly10.0HOXD13
38malignant mesothelioma10.0NAT2
39herpes simplex10.0COL1A1
40polydactyly10.0GLI3, HOXD12, HOXD13
41myocardial infarction10.0CFH
42acute leukemia10.0APAF1, CASP8
43retinal drusen10.0CFH
44pseudoachondroplasia10.0COL9A1, SLC26A2
45hepatitis10.0NAT2, CASP8
46amyotrophic lateral sclerosis10.0APAF1, CASP3
47rheumatoid arthritis10.0NAT2, HOXD13, CASP8
48cataract10.0NAT2, NAT1, CASP9
49cholangiocarcinoma10.0NAT2, NAT1, CASP9
50transitional cell carcinoma10.0NAT2, APAF1, NAT1

Graphical network of the top 20 diseases related to Talipes Equinovarus:



Diseases related to talipes equinovarus

Clinical Features for Talipes Equinovarus

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Drugs & Therapeutics for Talipes Equinovarus

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Genetic Tests for Talipes Equinovarus

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22GTR
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Genetic tests related to Talipes Equinovarus:

id Genetic test Affiliating Genes
1 Talipes Equinovarus22

Anatomical Context for Talipes Equinovarus

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Animal Models for Talipes Equinovarus or affiliated genes

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36MGI
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Publications for Talipes Equinovarus

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Genetic Variations for Talipes Equinovarus

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Expression for genes affiliated with Talipes Equinovarus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Talipes Equinovarus

Search GEO for disease gene expression data for Talipes Equinovarus.

Pathways for genes affiliated with Talipes Equinovarus

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53Reactome, 49PharmGKB, 29KEGG, 37NCBI BioSystems Database, 55SinoBiological, 12EMD Millipore, 51QIAGEN, 59Tocris Bioscience, 52R&D Systems, 4Cell Signaling Technology
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Pathways related to Talipes Equinovarus according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.9CASP8, CASP10
2
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9.9CASP8, CASP10
39.9NAT2, NAT1
4
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9.9NAT1, NAT2
59.9NAT1, NAT2
69.5CASP9, CASP3
79.3CASP10, CASP3, CASP9
89.3CASP8, BID
9
Apoptosis and survival Lymphotoxin-beta receptor signaling
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9.3CASP3, APAF1, CASP9
10
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9.3CASP3, APAF1, CASP9
11
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9.3APAF1, CASP9, CASP3
129.3APAF1, CASP3, CASP9
139.3APAF1, CASP3, CASP9
149.3APAF1, CASP9, CASP3
15
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9.2CASP8, CASP3, CASP9
169.2CASP3, CASP8, CASP9
17
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9.0CASP3, CASP8, CASP10, CASP9
18
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9.0CASP10, CASP9, CASP8, CASP3
19
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9.0CASP10, CASP9, CASP8, CASP3
20
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9.0CASP9, CASP3, CASP10, CASP8
21
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9.0CASP8, CASP9, CASP10, CASP3
229.0CASP3, CASP8, CASP10, CASP9
238.9CASP8, CASP3, CASP9, APAF1
24
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8.9CASP9, CASP8, APAF1, CASP3
258.7CASP10, CASP3, WNT7A, CASP9, CASP8
26
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8.7CASP9, APAF1, CASP8, CASP3, CASP10
27
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8.7CASP10, CASP3, CASP8, APAF1, CASP9
288.6APAF1, CASP9, CASP8, BID
29
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8.6CASP3, CASP8, BID, CASP10
30
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8.5BID, CASP9, CASP3, CASP10
31
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8.4CASP3, CASP9, APAF1, BID
328.4CASP9, CASP8, CASP3, BID
338.4CASP3, CASP9, BID, CASP8
34
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8.1BID, APAF1, CASP3, CASP8, CASP9
35
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8.1CASP3, CASP8, CASP9, APAF1, BID
368.1CASP3, CASP8, CASP9, APAF1, BID
37
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8.1CASP3, BID, APAF1, CASP9, CASP8
38
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8.1APAF1, CASP3, CASP8, CASP9, BID
397.9CASP8, CASP3, WNT7A, CASP9, GLI3, BID
40
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7.9CASP10, APAF1, BID, CASP9, CASP8, CASP3
41
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7.9CASP9, APAF1, CASP8, CASP10, BID, CASP3
42
Apoptosis and survival Caspase cascade
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7.9BID, APAF1, CASP9, CASP8, CASP10, CASP3
43
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7.9CASP10, CASP8, CASP3, APAF1, BID, CASP9
44
Apoptosis and survival Apoptotic TNF-family pathways
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7.9CASP10, CASP3, CASP8, CASP9, APAF1, BID
457.9CASP3, CASP10, CASP9, APAF1, BID, CASP8
467.9BID, CASP10, CASP3, CASP8, APAF1, CASP9
47
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7.9APAF1, CASP3, CASP9, CASP10, CASP8, BID
487.9BID, CASP10, CASP3, CASP8, CASP9, APAF1
49
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7.9APAF1, CASP10, BID, CASP3, CASP9, CASP8
50
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7.3APAF1, BID, COL9A1, CASP9, CASP8, COL1A1

Compounds for genes affiliated with Talipes Equinovarus

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44Novoseek, 28IUPHAR, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 2BitterDB
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Compounds related to Talipes Equinovarus according to GeneCards/GeneDecks:

(show top 50)    (show all 99)
idCompoundScoreTop Affiliating Genes
1n-hydroxyarylamine4410.1NAT1, NAT2
2nitroarenes4410.1NAT1, NAT2
3n-hydroxy-2-aminofluorene4410.1NAT2, NAT1
4paraphenylenediamine4410.1NAT1, NAT2
5codeinone449.9CASP8, CASP9
6dioscin28 4410.9CASP8, CASP9
7diosgenin449.8CASP9, CASP8
8tpen449.8CASP8, CASP3
9d-api449.6CASP3, CASP8, CASP9
10bongkrekic acid449.6CASP9, CASP8, CASP3
11shikonin449.6CASP9, CASP3, CASP8
127-ketocholesterol44 2410.6CASP9, CASP3, CASP8
13betulinic acid44 2810.6CASP3, CASP9, CASP8
14rhodamine 12344 4910.5CASP9, CASP8, CASP3
15vitamin e succinate449.5CASP8, CASP9, CASP3
162-chlorodeoxyadenosine449.5APAF1, CASP9, CASP8
17sulindac sulfide449.5CASP8, CASP9, CASP3
18z-devd-fmk59 2810.4CASP9, CASP8, CASP3, CASP10
19z-dqmd-fmk59 2810.4CASP10, CASP3, CASP8, CASP9
20az 10417808599.4CASP10, CASP3, CASP8, CASP9
21z-vad-fmk44 5910.4CASP9, CASP8, CASP3, CASP10
22celecoxib44 59 28 49 11 2414.3CASP8, CASP9, APAF1, CASP3
23lactacystin449.2APAF1, CASP9, CASP8, CASP3
24triptolide449.2CASP3, CASP8, CASP9
25calpeptin44 5910.0CASP9, CASP3, BID
26dexamethasone44 49 28 1111.9SLC26A2, CFH, NAT2, APAF1, CASP8, COL1A1
27cardiolipin44 119.9CASP9, CASP8, BID, CFH
28simvastatin44 49 59 28 11 2413.8COL1A1, CASP9, CASP3, CASP8
294,6-diamidino-2-phenylindole448.8CASP3, BID, CASP9, CASP8
30sanguinarine448.8CASP9, CASP8, CASP3, BID
31phenethyl isothiocyanate44 29.8BID, CASP8, CASP3, CASP9
32cd 437448.8BID, CASP3, CASP8, CASP9
33parthenolide44 29.8CASP3, CASP8, BID, CASP9
34suberoylanilide hydroxamic acid448.8CASP8, CASP9, BID, CASP3
35flavopiridol44 119.8BID, CASP9, CASP8, CASP3
36gemcitabine44 49 1110.7CASP8, CASP3, CASP9, BID
37sp 60012544 599.7CASP3, CASP8, CASP9, BID
38noxa448.5CASP8, CASP9, APAF1, CASP3, BID
39bortezomib44 119.5BID, APAF1, CASP9, CASP8, CASP3
40adpribose448.5BID, APAF1, CASP9, CASP8, CASP3
41camptothecin44 59 1110.5APAF1, CASP9, CASP3, CASP8, BID
42phosphatidylserine44 28 1110.5CASP8, BID, APAF1, CASP9, CASP3
43curcumin448.5CASP3, BID, CASP8, CASP9, NAT1
44docetaxel44 49 59 1111.5CASP3, CASP8, CASP9, NAT2, BID
45etoposide44 49 59 1111.4CASP3, APAF1, CASP9, CASP8, BID
46mg 13244 599.3CASP3, CASP8, BID, CASP9
47paclitaxel44 49 1110.0NAT1, BID, CASP9, CASP3, CASP10, APAF1
48cisplatin44 49 59 1110.8CASP8, CFH, BID, APAF1, CASP9, CASP3
49doxorubicin44 49 119.8CASP3, BID, CASP8, CASP9, APAF1
50cysteine446.7CASP3, COL1A1, CASP10, CASP8, CASP9, APAF1

GO Terms for genes affiliated with Talipes Equinovarus

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16Gene Ontology
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Cellular components related to Talipes Equinovarus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptosomeGO:0432939.8APAF1, CASP9
2cytosolGO:0058296.5BID, CASP10, CASP3, CASP8, CASP9, FHL1

Biological processes related to Talipes Equinovarus according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1anterior/posterior pattern specificationGO:0099529.6GLI3, HOXD13, HOXD10
2activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cGO:0086359.4APAF1, CASP3, CASP9
3apoptotic signaling pathwayGO:0971909.4CASP8, CASP10, CASP3
4embryonic digit morphogenesisGO:0427339.3HOXD12, WNT7A, GLI3, HOXD13
5skeletal system developmentGO:0015019.2HOXD12, HOXD13, PITX1, COL1A1
6neuron apoptotic processGO:0514029.0CASP3, APAF1, BID
7regulation of apoptotic processGO:0429818.9CASP9, CASP10, APAF1, CASP3
8intrinsic apoptotic signaling pathwayGO:0971938.3CASP3, CASP8, CASP9, APAF1, BID
9apoptotic processGO:0069157.9BID, CASP10, CASP3, APAF1, CASP9, CASP8

Molecular functions related to Talipes Equinovarus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1arylamine N-acetyltransferase activityGO:0040609.6NAT2, NAT1
2sequence-specific DNA bindingGO:0435659.0HOXD12, HOXD10, HOXD13, GLI3, PITX1
3cysteine-type endopeptidase activityGO:0041978.9CASP10, CASP9, CASP8, CASP3

Products for genes affiliated with Talipes Equinovarus

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Sources for Talipes Equinovarus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet