TD
MCID: TRD006
MIFTS: 52

Tardive Dyskinesia (TD) malady

Rare diseases, Oral diseases categories
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Summaries for Tardive Dyskinesia

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NINDS:43 Tardive dyskinesia is a neurological syndrome caused by the long-term use of neuroleptic drugs. Neuroleptic drugs are generally prescribed for psychiatric disorders, as well as for some gastrointestinal and neurological disorders. Tardive dyskinesia is characterized by repetitive, involuntary, purposeless movements. Features of the disorder may include grimacing, tongue protrusion, lip smacking, puckering and pursing, and rapid eye blinking. Rapid movements of the arms, legs, and trunk may also occur. Involuntary movements of the fingers may be present.

MalaCards based summary: Tardive Dyskinesia, also known as tardive oral dyskinesia, is related to schizophrenia and gilles de la tourette syndrome, and has symptoms including An important gene associated with Tardive Dyskinesia is FGFR3 (fibroblast growth factor receptor 3), and among its related pathways are FGFR ligand binding and activation and Estrogen metabolism. The compounds (-)-sulpiride and pazopanib have been mentioned in the context of this disorder. Affiliated tissues include tongue, eye and brain, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Wikipedia:65 Tardive dyskinesia /?t?rd?v ?d?sk??ni???/ is a difficult-to-treat and often incurable form of... more...

Aliases & Classifications for Tardive Dyskinesia

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Tardive Dyskinesia, Aliases & Descriptions:

Name: Tardive Dyskinesia 42 43
Tardive Oral Dyskinesia 42 62
Lingual-Facial-Buccal Dyskinesia 62
Thanatophoric Dysplasia, Type I 62
 
Linguofacial Dyskinesia 42
Tardive Dystonia 42
Td 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Oral diseases


Related Diseases for Tardive Dyskinesia

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Diseases related to Tardive Dyskinesia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.0CYP2D6, CYP1A2, NQO1, DRD4, DRD3
2gilles de la tourette syndrome30.5DRD4, DRD3
3parkinson's disease30.4DRD3, CYP2D6
4bipolar disorder30.3HSPG2, DRD4, DRD3
5hepatitis30.0CYP2D6, CYP1A2, HSPG2
6schizoaffective disorder30.0DRD3, DRD4, CYP2D6
7alzheimer's disease29.4CYP2D6, NQO1, HSPG2, DRD4, DRD3, FGFR3
8blindness10.7
9dystonia10.6
10mood disorder10.4
11delusional disorder10.4DRD4
12huntington's disease10.3
13neuronitis10.3
14dementia10.3
15hypothyroidism10.3
16drug induced dyskinesia10.3
17neuroleptic malignant syndrome10.2CYP2D6
18personality disorder10.2DRD3, DRD4
19pathological gambling10.2DRD4, DRD3
20cataract10.2
21major depressive disorder10.2
22multiple sclerosis10.2
23bipolar i disorder10.2
24myelitis10.2
25blepharospasm10.2
26rocky mountain spotted fever10.2
27olecranon bursitis10.2
28lewy body dementia10.2
29anosognosia10.2
30cerebritis10.2
31bursitis10.2
32cervicitis10.2
33megacolon10.2
34spotted fever10.2
35developmental disabilities10.2
36childhood-onset schizophrenia10.2
37back pain10.2
38dysphagia10.2
39endotheliitis10.2
40skeletal dysplasia multi-gene panels10.2FGFR3, HSPG2
41substance dependence10.2DRD4, DRD3
42alcohol dependence10.2ANKK1, DRD4
43diffuse idiopathic skeletal hyperostosis10.2
44cervical dystonia10.2
45hyperostosis10.2
46spasmodic dysphonia10.2
47heroin dependence10.2DRD4, ANKK1
48obsessive-compulsive disorder10.1DRD4, DRD3
49substance abuse10.1DRD3, DRD4
50bladder carcinoma10.1FGFR3, NQO1

Graphical network of the top 20 diseases related to Tardive Dyskinesia:



Diseases related to tardive dyskinesia

Symptoms for Tardive Dyskinesia

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HPO human phenotypes related to Tardive Dyskinesia:

id Description Frequency HPO Source Accession
1 autosomal recessive inheritance HP:0000007
2 abnormality of the nervous system HP:0000707

Drugs & Therapeutics for Tardive Dyskinesia

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Drug clinical trials:

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Genetic Tests for Tardive Dyskinesia

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Anatomical Context for Tardive Dyskinesia

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MalaCards organs/tissues related to Tardive Dyskinesia:

32
Tongue, Eye, Brain, Globus pallidus, Cortex, Testes, Endothelial

Animal Models for Tardive Dyskinesia or affiliated genes

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MGI Mouse Phenotypes related to Tardive Dyskinesia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.5NQO1, HSPG2, DRD4, DRD3, FGFR3, CYP1A2
2MP:00053867.2FGFR3, SIGMAR1, DRD3, DRD4, HSPG2, CYP1A2

Publications for Tardive Dyskinesia

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Articles related to Tardive Dyskinesia:

(show top 50)    (show all 545)
idTitleAuthorsYear
1
Dehydroepiandrosterone sulphate as a putative protective factor against tardive dyskinesia. (24389397)
2014
2
Clinical significance of pharmacogenomic studies in tardive dyskinesia associated with patients with psychiatric disorders. (25378945)
2014
3
Reduced serum TNF alpha level in chronic schizophrenia patients with or without tardive dyskinesia. (24995685)
2014
4
Suppression of antipsychotic-induced tardive dyskinesia with aripiprazole in an elderly patient with bipolar I disorder. (25142102)
2014
5
Structural brain changes associated with tardive dyskinesia in schizophrenia. (23222039)
2013
6
The relevance of EEG artifact identification: a case of "delta-wave blinking" due to tardive dyskinesia. (23422518)
2013
7
New and emerging treatments for symptomatic tardive dyskinesia. (24235816)
2013
8
Tardive dyskinesia in schizophrenia. (23818532)
2013
9
Do tardive dyskinesia and L-dopa induced dyskinesia share common genetic risk factors? An exploratory study. (23666822)
2013
10
Aquaporin-4 knockout abolishes apomorphine-induced tardive dyskinesia following chronic treatment with neuroleptics. (23126383)
2012
11
Tetrabenazine for the treatment of tardive dyskinesia. (21487088)
2011
12
Tardive dyskinesia. (21365202)
2011
13
Alpha-phenyl-N-tert-butylnitrone prevents oxidative stress in a haloperidol-induced animal model of tardive dyskinesia: investigating the behavioural and biochemical changes. (21816389)
2011
14
Tardive dyskinesia: treatment with aripiprazole. (23430384)
2011
15
Rational antipsychotic choice: weighing the risk of tardive dyskinesia and metabolic syndrome. (21916828)
2011
16
Treatment outcomes of patients with tardive dyskinesia and chronic schizophrenia. (20816031)
2011
17
Phosphodiesterase 4B genetic variants are not associated with antipsychotic-induced tardive dyskinesia. (20436352)
2010
18
Dysphagia due to tardive dyskinesia. (22174539)
2010
19
Rapid improvement of neuroleptic-induced tardive dyskinesia with levetiracetam in an interictal psychotic patient. (20520300)
2010
20
Glial cell line-derived neurotrophic factor receptor alpha 2 (GFRA2) gene is associated with tardive dyskinesia. (20369355)
2010
21
Association study of tardive dyskinesia and five DRD4 polymorphisms in schizophrenia patients. (19238168)
2009
22
MDR1 gene in tardive dyskinesia scale scores: comparison of strategies for quantitative trait haplotype analysis. (19282152)
2009
23
Motor worsening and tardive dyskinesia with aripiprazole in Lewy body dementia. (21686897)
2009
24
Analysis of genetic variations in the RGS9 gene and antipsychotic-induced tardive dyskinesia in schizophrenia. (18548510)
2009
25
Aripiprazole improves neuroleptic-associated tardive dyskinesia, but it does not meliorate psychotic symptoms. (18433967)
2008
26
Pain and denture condition in edentulous orodyskinesia: comparisons with tardive dyskinesia and control subjects. (18759358)
2008
27
Support for an association of the C939T polymorphism in the human DRD2 gene with tardive dyskinesia in schizophrenia. (17669630)
2007
28
Comparative assessment of the incidence and severity of tardive dyskinesia in patients receiving aripiprazole or haloperidol for the treatment of schizophrenia: a post hoc analysis. (18162021)
2007
29
Tardive dyskinesia circa 2006. (16877639)
2006
30
Multidose risperidone treatment evaluated in a rodent model of tardive dyskinesia. (16319911)
2006
31
Focus on lower risk of tardive dyskinesia with atypical antipsychotics. (16517454)
2006
32
The human dopamine receptor D2 (DRD2) gene is associated with tardive dyskinesia in patients with schizophrenia. (16769201)
2006
33
Improvement in tardive dyskinesia with aripiprazole use. (15830835)
2005
34
Association analysis of NAD(P)Hratioquinone oxidoreductase (NQO1) Pro187Ser genetic polymorphism and tardive dyskinesia in patients with schizophrenia in Taiwan. (15836802)
2005
35
Tardive dyskinesia in the era of typical and atypical antipsychotics. Part 2: Incidence and management strategies in patients with schizophrenia. (16363464)
2005
36
Tardive dyskinesia after long-term veralipride treatment. (15939983)
2005
37
Risperidone and olanzapine induced tardive dyskinesia : a critical review of reported cases. (21206790)
2004
38
Tardive dyskinesia in 2 patients treated with ziprasidone. (15644988)
2004
39
Mu opioid receptor gene polymorphism and neuroleptic-induced tardive dyskinesia in patients with schizophrenia. (14623376)
2003
40
Treatment-emergent tardive dyskinesia with quetiapine in mood disorders. (12920421)
2003
41
Interaction between polymorphisms of the dopamine D3 receptor and manganese superoxide dismutase genes in susceptibility to tardive dyskinesia. (12960753)
2003
42
Pathophysiology and drug therapy of tardive dyskinesia: current concepts and future perspectives. (12669107)
2003
43
Quetiapine-induced improvement of tardive dyskinesia in three patients with schizophrenia. (12177588)
2002
44
Prevalence of tardive dyskinesia among psychiatric in-patients at Mathari Hospital, Nairobi. (12635762)
2002
45
Rapid onset of tardive dyskinesia in Huntington disease with olanzapine. (12172349)
2002
46
Genetic association analysis of 5-HT(6) receptor gene polymorphism (267C/T) with tardive dyskinesia. (12057822)
2002
47
Tardive dyskinesia: legal issues and consent. (12774783)
2002
48
Lack of association between a functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene and tardive dyskinesia in schizophrenia. (11496364)
2001
49
Association between the serotonin 2A receptor gene and tardive dyskinesia in chronic schizophrenia. (11317227)
2001
50
Association of the MscI polymorphism of the dopamine D3 receptor gene with tardive dyskinesia in schizophrenia. (10379516)
1999

Variations for Tardive Dyskinesia

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Clinvar genetic disease variations for Tardive Dyskinesia:

6 (show all 13)
id Gene Name Type Significance SNP ID Assembly Location
1FGFR3NM_000142.4(FGFR3): c.742C> T (p.Arg248Cys)single nucleotide variantPathogenicrs121913482GRCh37Chr 4, 1803564: 1803564
2FGFR3NM_000142.4(FGFR3): c.1111A> T (p.Ser371Cys)single nucleotide variantPathogenicrs121913484GRCh37Chr 4, 1806092: 1806092
3FGFR3NM_000142.4(FGFR3): c.2419T> G (p.Ter807Gly)single nucleotide variantPathogenicrs121913101GRCh37Chr 4, 1808987: 1808987
4FGFR3NM_000142.4(FGFR3): c.2419T> A (p.Ter807Arg)single nucleotide variantPathogenicrs121913101GRCh37Chr 4, 1808987: 1808987
5FGFR3NM_000142.4(FGFR3): c.2421A> T (p.Ter807Cys)single nucleotide variantPathogenicrs121913103GRCh37Chr 4, 1808989: 1808989
6FGFR3NM_000142.4(FGFR3): c.746C> G (p.Ser249Cys)single nucleotide variantPathogenicrs121913483GRCh37Chr 4, 1803568: 1803568
7FGFR3NM_000142.4(FGFR3): c.1949A> T (p.Lys650Met)single nucleotide variantPathogenicrs121913105GRCh37Chr 4, 1807890: 1807890
8FGFR3NM_000142.4(FGFR3): c.1118A> G (p.Tyr373Cys)single nucleotide variantPathogenicrs121913485GRCh37Chr 4, 1806099: 1806099
9FGFR3NM_000142.4(FGFR3): c.1108G> T (p.Gly370Cys)single nucleotide variantPathogenicrs121913479GRCh37Chr 4, 1806089: 1806089
10FGFR3NM_000142.4(FGFR3): c.2419T> C (p.Ter807Arg)single nucleotide variantPathogenicrs121913101GRCh37Chr 4, 1808987: 1808987
11FGFR3NM_000142.4(FGFR3): c.2420G> T (p.Ter807Leu)single nucleotide variantPathogenicrs397515514GRCh37Chr 4, 1808988: 1808988
12FGFR3NM_000142.4(FGFR3): c.2421A> C (p.Ter807Cys)single nucleotide variantPathogenicrs121913103GRCh37Chr 4, 1808989: 1808989
13FGFR3NM_000142.4(FGFR3): c.2421A> G (p.Ter807Trp)single nucleotide variantPathogenicrs121913103GRCh37Chr 4, 1808989: 1808989

Expression for genes affiliated with Tardive Dyskinesia

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Expression patterns in normal tissues for genes affiliated with Tardive Dyskinesia

Search GEO for disease gene expression data for Tardive Dyskinesia.

Pathways for genes affiliated with Tardive Dyskinesia

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Pathways related to Tardive Dyskinesia according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7FGFR3, HSPG2
2
Show member pathways
9.5NQO1, CYP1A2
3
Show member pathways
AhR pathway37
9.5CYP1A2, NQO1
49.3CYP2D6, CYP1A2
5
Show member pathways
9.3CYP1A2, CYP2D6
6
Show member pathways
Retinol metabolism60
9.3CYP1A2, CYP2D6
7
Show member pathways
9.3CYP1A2, CYP2D6
8
Show member pathways
Nicotine Activity on Dopaminergic Neurons37
9.2DRD3, DRD4
9
Show member pathways
9.2DRD3, DRD4
10
Show member pathways
9.0NQO1, CYP1A2, CYP2D6
11
Show member pathways
8.7CYP2D6, DRD4, DRD3

Compounds for genes affiliated with Tardive Dyskinesia

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Compounds related to Tardive Dyskinesia according to GeneCards/GeneDecks:

(show top 50)    (show all 262)
idCompoundScoreTop Affiliating Genes
1(-)-sulpiride289.4DRD3, DRD4
2pazopanib50 1110.4CYP2D6, CYP1A2, FGFR3
3(+)-sulpiride289.4DRD3, DRD4
4dextromethorphan2 50 24 1112.3SIGMAR1, CYP1A2, CYP2D6
5chlorzoxazone44 28 1111.3NQO1, CYP1A2, CYP2D6
6n-desmethylclozapine449.3CYP1A2, DRD4
7beta-naphthoflavone44 1110.3NQO1, CYP2D6, CYP1A2
8coumarin44 2 50 2412.3NQO1, CYP2D6, CYP1A2
9tolbutamide44 28 50 1112.3NQO1, CYP2D6, CYP1A2
10duloxetine44 50 28 1112.3DRD3, CYP1A2, CYP2D6
11domperidone44 28 1111.3CYP2D6, DRD3, CYP1A2
12pimozide28 44 50 1112.3DRD3, CYP2D6, CYP1A2
13ketoconazole44 28 24 1112.2NQO1, CYP1A2, CYP2D6
14methadone50 44 1111.2CYP1A2, CYP2D6, ANKK1
15epoxide449.1NQO1, CYP2D6, CYP1A2
16xanthine44 2410.1NQO1, CYP2D6, CYP1A2
17eticlopride44 2810.1DRD4, DRD3
18nemonapride44 50 2811.1DRD3, DRD4, ANKK1
196-hydroxydopamine449.1DRD3, NQO1, DRD4
20piperazine44 1110.1DRD4, DRD3, CYP2D6
21lisuride44 28 1111.0DRD4, CYP2D6, DRD3
22pergolide44 28 1111.0CYP2D6, DRD4, DRD3
23aripiprazole28 44 50 24 1113.0DRD4, DRD3, CYP2D6
24bortezomib44 50 1111.0CYP1A2, FGFR3, CYP2D6
25quetiapine44 50 28 24 1113.0DRD3, DRD4, CYP2D6
26imipramine44 28 50 24 1112.9CYP2D6, DRD3, CYP1A2
27methamphetamine44 50 1110.9DRD4, CYP2D6, DRD3
28fluphenazine28 44 50 1111.9CYP2D6, DRD4, CYP1A2
29bromocriptine44 28 1110.9CYP1A2, DRD3, DRD4
30antipsychotics508.8CYP1A2, CYP2D6, HSPG2, ANKK1
31bupropion50 44 24 1111.8CYP2D6, ANKK1, DRD3, CYP1A2
32remoxipride44 119.8DRD4, CYP2D6, SIGMAR1, DRD3
33cocaine44 119.7DRD4, SIGMAR1, DRD3, CYP2D6
34propranolol44 28 50 24 1112.6CYP2D6, HSPG2, CYP1A2
35risperidone44 50 28 61 24 1113.6DRD3, DRD4, ANKK1, CYP2D6
36dexamethasone44 50 28 1111.5CYP1A2, CYP2D6, HSPG2, FGFR3, NQO1
37rotigotine28 44 1110.5CYP2D6, CYP1A2, DRD4, DRD3
38ropinirole44 119.5CYP1A2, DRD4, DRD3, CYP2D6
39paliperidone44 119.5DRD3, CYP2D6, CYP1A2, DRD4
40iloperidone50 44 28 1111.5CYP2D6, DRD3, DRD4, CYP1A2
41asenapine28 119.5DRD3, DRD4, CYP2D6, CYP1A2
42ziprasidone28 50 44 1111.5DRD3, DRD4, CYP1A2, CYP2D6
43paroxetine44 50 28 1111.5CYP2D6, DRD3, CYP1A2, DRD4
44chlorpromazine28 44 50 1111.5DRD3, DRD4, CYP1A2, CYP2D6
45norepinephrine44 24 1110.2NQO1, CYP1A2, DRD3, DRD4
46haloperidol44 50 28 2 1112.1CYP2D6, CYP1A2, DRD4, DRD3, SIGMAR1
47olanzapine44 50 28 24 1112.0ANKK1, CYP1A2, DRD3, CYP2D6, DRD4
48clozapine44 28 50 1111.0CYP1A2, CYP2D6, ANKK1, DRD4, DRD3
49nicotine44 28 50 1110.9DRD3, DRD4, CYP2D6, CYP1A2, ANKK1
50dopamine44 28 24 1110.8CYP1A2, DRD4, DRD3, SIGMAR1, CYP2D6, NQO1

GO Terms for genes affiliated with Tardive Dyskinesia

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Cellular components related to Tardive Dyskinesia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.5FGFR3, SIGMAR1, DRD3, DRD4

Biological processes related to Tardive Dyskinesia according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1endochondral ossificationGO:0019589.8HSPG2, FGFR3
2positive regulation of neuron apoptotic processGO:0435259.8FGFR3, NQO1
3alkaloid metabolic processGO:0098209.7CYP1A2, CYP2D6
4drug catabolic processGO:0427379.7CYP2D6, CYP1A2
5chondrocyte differentiationGO:0020629.6HSPG2, FGFR3
6heterocycle metabolic processGO:0464839.6CYP2D6, CYP1A2
7monoterpenoid metabolic processGO:0160989.6CYP2D6, CYP1A2
8oxidative demethylationGO:0709899.6CYP1A2, CYP2D6
9response to histamineGO:0347769.5DRD3, DRD4
10adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:0071959.5DRD4, DRD3
11dopamine metabolic processGO:0424179.5DRD4, DRD3
12synaptic transmission, dopaminergicGO:0019639.5DRD3, DRD4
13drug metabolic processGO:0171449.4CYP2D6, CYP1A2
14negative regulation of protein secretionGO:0507099.4DRD3, DRD4
15behavioral response to cocaineGO:0481489.4DRD4, DRD3
16arachidonic acid secretionGO:0504829.4DRD4, DRD3
17negative regulation of adenylate cyclase activityGO:0071949.3DRD3, DRD4
18response to amphetamineGO:0019759.2DRD3, DRD4
19xenobiotic metabolic processGO:0068059.2NQO1, CYP1A2, CYP2D6
20social behaviorGO:0351768.9DRD3, DRD4

Molecular functions related to Tardive Dyskinesia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1monooxygenase activityGO:0044979.3CYP2D6, CYP1A2
2dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.2DRD3, DRD4
3dopamine bindingGO:0352409.1DRD3, DRD4
4aromatase activityGO:0703309.0CYP1A2, CYP2D6
5drug bindingGO:0081448.4DRD4, CYP2D6, DRD3, SIGMAR1

Products for genes affiliated with Tardive Dyskinesia

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Sources for Tardive Dyskinesia

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3CDC
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24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
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58SNOMED-CT via Orphanet
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