TD
MCID: TRD006
MIFTS: 45

Tardive Dyskinesia (TD) malady

Oral diseases category

Summaries for Tardive Dyskinesia

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Tardive dyskinesia is a neurological syndrome caused by the long-term use of neuroleptic drugs. Neuroleptic drugs are generally prescribed for psychiatric disorders, as well as for some gastrointestinal and neurological disorders. Tardive dyskinesia is characterized by repetitive, involuntary, purposeless movements. Features of the disorder may include grimacing, tongue protrusion, lip smacking, puckering and pursing, and rapid eye blinking. Rapid movements of the arms, legs, and trunk may also occur. Involuntary movements of the fingers may be present.

MalaCards: Tardive Dyskinesia, also known as lingual-facial-buccal dyskinesia, is related to schizophrenia and mood disorder. An important gene associated with Tardive Dyskinesia is NQO1 (NAD(P)H dehydrogenase, quinone 1), and among its related pathways are Doxepin Pathway, Pharmacokinetics and Ifosfamide Pathway, Pharmacokinetics. The compounds remoxipride and duloxetine have been mentioned in the context of this disorder. Affiliated tissues include tongue and eye, and related mouse phenotypes are adipose tissue and immune system.

Wikipedia:63 Tardive dyskinesia /ˈtɑrdɨv ˌdɪskɨˈniːʒə/ is a difficult-to-treat and often incurable form of... more...

Aliases & Classifications for Tardive Dyskinesia

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60UMLS, 42NIH Rare Diseases, 43NINDS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


Aliases & Descriptions:

tardive dyskinesia 42 43
lingual-facial-buccal dyskinesia 60
thanatophoric dysplasia, type i 60
linguofacial dyskinesia 42
tardive oral dyskinesia 42
tardive dystonia 42
td 42


Related Diseases for Tardive Dyskinesia

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17GeneCards, 18GeneDecks
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Diseases related to Tardive Dyskinesia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.7COMT, HTR2A, DRD3
2mood disorder30.5HTR2A, HTR6, DRD1, DRD2, DRD3, DRD4
3dementia30.4COMT, MAOB, HTR2A, CYP2D6
4bipolar disorder30.4HTR2A, DRD2
5alzheimer's disease30.4CYP2D6, DRD2, HTR2C, SOD2, HSPG2, MTNR1A
6huntington's disease30.4MAOB, DRD1, DRD2
7personality disorder30.1DRD2, MAOB, DRD4, DRD3
8multiple sclerosis30.1COMT, HSPG2, DRD2, CYP2D6
9gilles de la tourette syndrome30.1DRD4, DRD2
10parkinson's disease30.1DRD2, DRD3, MAOB, CYP2D6, COMT
11schizoaffective disorder30.1DRD4, CYP2D6, DRD2, DRD3, COMT, HTR2A
12colorectal cancer30.1NQO1, CYP1A2, CYP2D6, DRD2, COMT
13attention deficit hyperactivity disorder29.9COMT, HTR2C, HTR2A, DRD1, DRD2, DRD4
14lingual-facial-buccal dyskinesia10.7
15diphtheria10.4
16tetanus10.4
17thanatophoric dysplasia10.3
18thanatophoric dysplasia type 210.3
19thanatophoric dysplasia type 110.3
20neuronitis10.3
21hypothyroidism10.3
22intellectual disability10.3
23achondroplasia10.3
24syndactyly10.3
25hypochondroplasia10.3
26platyspondylic lethal skeletal dysplasia torrance type10.3
27mitochondrial disorders10.2
28major depressive disorder10.1
29myelitis10.1
30lewy body dementia10.1
31cerebritis10.1
32blepharospasm10.1
33anosognosia10.1
34rocky mountain spotted fever10.1
35olecranon bursitis10.1
36brain disease10.1
37bursitis10.1
38cataract10.1
39cervicitis10.1
40hepatitis10.1
41megacolon10.1
42spotted fever10.1
43tic disorder10.1
44developmental disabilities10.1
45drug induced dyskinesia10.1
46diffuse idiopathic skeletal hyperostosis10.1
47hyperostosis10.1
48pertussis10.1
49restless legs syndrome10.0DRD2
50cocaine dependence10.0DRD2, DRD3

Graphical network of the top 20 diseases related to Tardive Dyskinesia:



Diseases related to tardive dyskinesia

Clinical Features for Tardive Dyskinesia

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Drugs & Therapeutics for Tardive Dyskinesia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Tardive Dyskinesia

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Anatomical Context for Tardive Dyskinesia

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32MalaCards
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MalaCards organs/tissues related to Tardive Dyskinesia:

32
Tongue, Eye

Animal Models for Tardive Dyskinesia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Tardive Dyskinesia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.2HTR2C, HTR6, DRD2, DRD3
2MP:000538710.1NQO1, DRD2, DRD1, HTR2C, HSPG2, SOD2
3MP:00053869.9MTNR1A, DRD3, DRD2, DRD1, HTR6, HTR2A
4MP:00053769.9HTR6, DRD3, DRD2, DRD1, MAOB, NQO1
5MP:00036319.7COMT, HSPG2, GPX1, MAOB, DRD4, DRD3

Publications for Tardive Dyskinesia

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Genetic Variations for Tardive Dyskinesia

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Expression for genes affiliated with Tardive Dyskinesia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tardive Dyskinesia

Search GEO for disease gene expression data for Tardive Dyskinesia.

Pathways for genes affiliated with Tardive Dyskinesia

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Sources:
49PharmGKB, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 29KEGG
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Pathways related to Tardive Dyskinesia according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.4CYP2D6, CYP1A2
2
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10.4CYP1A2, CYP2D6
3
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10.4CYP1A2, CYP2D6
4
Acetaminophen metabolism
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10.4CYP2D6, NQO1, CYP1A2
510.4DRD4, DRD3, HTR2A
6
Hide members
10.3COMT, CYP1A2, NQO1
710.3DRD1, DRD2, DRD4
8
Hide members
10.3COMT, CYP2D6, CYP1A2
910.3GPX1, SOD2, NQO1
10
Hide members
10.3MAOB, CYP1A2, CYP2D6
1110.3DRD4, DRD3, DRD1, DRD2
1210.3DRD3, DRD4, DRD1, DRD2
13
Hide members
10.3DRD2, DRD1, DRD3, DRD4
14
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10.3DRD1, DRD3, DRD4, DRD2
15
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10.3CYP1A2, CYP2D6, NQO1, COMT
16
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10.3CYP2D6, CYP1A2, COMT, MAOB
17
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10.3HTR2C, DRD2, HTR2A, DRD1
1810.3HTR2C, DRD1, HTR2A, HTR6
19
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10.1HTR2C, DRD4, DRD3, DRD2, DRD1, HTR2A
20
Hide members
10.0DRD3, HTR6, HTR2C, HTR2A, DRD1, MTNR1A
21
Hide members
10.0MTNR1A, MTNR1B, DRD4, HSPG2, HTR2C, DRD3
22
Hide members
9.9DRD4, HTR2C, HTR2A, HTR6, DRD1, COMT

Compounds for genes affiliated with Tardive Dyskinesia

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Tardive Dyskinesia according to GeneCards/GeneDecks:

(show top 50)    (show all 351)
idCompoundScoreTop Affiliating Genes
1remoxipride44 1111.7HTR2A, DRD2, DRD3, DRD4, CYP2D6, SIGMAR1
2duloxetine44 49 28 1113.6HTR2C, HTR2A, HTR6, DRD3, CYP1A2, CYP2D6
3pramipexole44 49 28 1113.6DRD2, DRD3, DRD4, DRD1, HTR2A, HTR2C
4loxapine28 44 1112.6DRD4, DRD2, DRD1, HTR2C, HTR2A, HTR6
5rotigotine44 28 1112.6DRD1, DRD2, DRD4, MAOB, CYP1A2, CYP2D6
6perphenazine49 28 44 1113.6HTR2C, HTR2A, HTR6, DRD1, DRD2, CYP1A2
7iloperidone49 44 28 1113.6HTR2A, HTR6, DRD1, DRD2, DRD3, DRD4
8fluphenazine28 44 1112.6HTR2A, HTR6, DRD1, DRD2, DRD4, CYP1A2
9thioridazine28 44 49 1113.5HTR2C, HTR2A, HTR6, DRD1, DRD2, CYP1A2
10paliperidone44 1111.5CYP2D6, HTR2C, HTR2A, DRD1, DRD2, DRD3
11Methotrimeprazine1110.5HTR2C, HTR2A, DRD1, DRD2, DRD3, DRD4
12quetiapine44 49 28 11 2414.5HTR2C, HTR2A, HTR6, DRD1, DRD2, DRD3
13aripiprazole28 49 44 11 2414.5HTR2C, HTR2A, HTR6, DRD1, DRD2, DRD3
14spiperone28 4411.5DRD2, HTR2A, DRD4, DRD3, DRD1, HTR2C
15ziprasidone49 28 44 1113.5HTR2C, HTR2A, HTR6, DRD1, DRD2, DRD3
16(+)-butaclamol28 4411.5HTR2A, DRD1, DRD2, DRD3, DRD4
176-hydroxydopamine4410.5COMT, SOD2, DRD1, DRD2, DRD3, DRD4
18methylphenidate44 49 1112.5COMT, CYP2D6, DRD1, MAOB, DRD4, DRD2
19methamphetamine44 49 1112.5COMT, SOD2, DRD1, DRD2, DRD4, MAOB
20cabergoline28 44 1112.5HTR2C, COMT, HTR2A, DRD1, DRD2, DRD3
21bupropion44 49 11 2413.5COMT, ANKK1, DRD2, DRD3, MAOB, CYP1A2
22promazine44 1111.5DRD4, HTR2A, DRD2, HTR2C, CYP1A2, DRD1
23apomorphine44 28 1112.5HTR2C, HTR2A, DRD1, DRD2, DRD3, DRD4
24haloperidol44 28 2 49 1114.5DRD3, DRD4, MAOB, CYP1A2, CYP2D6, SIGMAR1
25thiothixene28 1111.5DRD2, CYP1A2, DRD1, HTR2A, CYP2D6
26pergolide28 44 1112.5DRD4, HTR2A, HTR2C, COMT, CYP2D6, DRD3
27quinpirole44 2811.5HTR2A, DRD1, DRD4, DRD2, DRD3, HTR2C
28asenapine28 1111.5HTR2C, HTR2A, HTR6, DRD1, DRD2, DRD3
29lisuride28 44 1112.5DRD2, DRD3, DRD1, HTR6, HTR2A, HTR2C
30agomelatine28 44 1112.5CYP1A2, HTR2C, MTNR1B, MTNR1A, HTR2A
31maoa4410.5HTR2A, DRD2, HTR2C, COMT, DRD4, MAOB
32risperidone28 44 49 59 11 2415.5COMT, HTR2C, HTR2A, HTR6, DRD1, DRD2
33chlorpromazine44 28 49 1113.4HTR2C, HTR2A, HTR6, DRD1, DRD2, DRD3
34antipsychotics4910.4HTR2C, COMT, CYP1A2, ANKK1, DRD2
35ropinirole44 1111.4DRD4, MAOB, CYP1A2, CYP2D6, DRD3, DRD2
36olanzapine49 44 28 11 2414.4HTR6, DRD1, DRD2, DRD3, DRD4, ANKK1
37clozapine44 28 49 1113.4COMT, HTR2C, HTR2A, HTR6, DRD1, DRD2
38cocaine44 1111.4MAOB, DRD4, DRD3, CYP2D6, SIGMAR1, DRD2
39Pipotiazine1110.4CYP2D6, HTR2A, DRD2, DRD1, CYP1A2
40nicotine44 49 28 1113.4DRD4, COMT, DRD1, DRD2, DRD3, MAOB
41norepinephrine44 11 2412.4CYP1A2, NQO1, MAOB, HTR2C, HTR2A, HTR6
42bromocriptine28 44 1112.4DRD4, CYP1A2, DRD1, DRD3, DRD2, COMT
43minaprine44 1111.3HTR2C, HTR2A, DRD1, DRD2, CYP2D6
44paroxetine44 49 28 1113.3CYP2D6, CYP1A2, DRD4, DRD3, COMT, HTR2A
455-hydroxytryptamine4410.3DRD2, HTR6, HTR2A, COMT, HSPG2, HTR2C
46raclopride44 2811.3DRD2, HTR2A, DRD1, DRD3, DRD4
47amoxapine44 28 1112.2DRD2, DRD1, HTR6, HTR2A, CYP2D6
48dopamine44 28 11 2413.2COMT, SOD2, HTR2C, HTR2A, HTR6, DRD1
49roxindole28 4411.2HTR2C, HTR2A, DRD4, DRD3, DRD2
50levodopa44 1110.9MAOB, DRD4, CYP2D6, DRD3, DRD2, DRD1

GO Terms for genes affiliated with Tardive Dyskinesia

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16Gene Ontology
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Cellular components related to Tardive Dyskinesia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588610.0COMT, HSPG2, MTNR1B, DRD4, DRD3, DRD2
2integral to plasma membraneGO:0058879.7HTR2C, MTNR1A, MTNR1B, DRD4, DRD3, DRD2

Biological processes related to Tardive Dyskinesia according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idNameGO IDScoreTop Affiliating Genes
1response to histamineGO:03477610.8DRD2, DRD3, DRD4
2adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.8DRD3, DRD2, DRD4
3regulation of dopamine uptake involved in synaptic transmissionGO:05158410.8DRD3, DRD2, DRD1
4negative regulation of protein secretionGO:05070910.8DRD4, DRD3, DRD2
5arachidonic acid secretionGO:05048210.8DRD2, DRD4, DRD3
6alkaloid metabolic processGO:00982010.8CYP2D6, CYP1A2
7regulation of dopamine secretionGO:01405910.8HTR2A, DRD3, DRD2
8dopamine metabolic processGO:04241710.8DRD2, DRD4, DRD3, DRD1
9positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.8DRD2, DRD4
10prepulse inhibitionGO:06013410.8DRD3, DRD1, DRD2
11behavioral response to cocaineGO:04814810.8DRD2, DRD1, DRD4, DRD3
12synaptic transmission, dopaminergicGO:00196310.8DRD3, DRD4, DRD2, DRD1
13negative regulation of voltage-gated calcium channel activityGO:190138610.8DRD2, DRD4
14negative regulation of adenylate cyclase activityGO:00719410.8DRD4, DRD3, DRD2
15negative regulation of dopamine receptor signaling pathwayGO:06016010.7DRD3, DRD2
16phospholipase C-activating serotonin receptor signaling pathwayGO:00720810.7HTR2C, HTR2A
17response to amphetamineGO:00197510.7DRD4, DRD3, DRD2, DRD1
18response to selenium ionGO:01026910.7MAOB, SOD2, GPX1
19elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.7HTR2C, DRD2, DRD1
20behavioral fear responseGO:00166210.7DRD4, HTR2C, DRD1
21temperature homeostasisGO:00165910.7GPX1, HTR2A, DRD2, DRD1
22regulation of cAMP metabolic processGO:03081410.7DRD2, DRD3
23release of sequestered calcium ion into cytosolGO:05120910.7DRD2, HTR2A, HTR2C
24positive regulation of phosphatidylinositol biosynthetic processGO:01051310.7HTR2A, HTR2C
25drug catabolic processGO:04273710.7CYP2D6, CYP1A2
26G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.7HTR6, MTNR1B, DRD1, MTNR1A
27cellular calcium ion homeostasisGO:00687410.7HTR2A, DRD3, DRD2, HTR2C, DRD4
28locomotory behaviorGO:00762610.7SOD2, HTR2C, DRD2, DRD3
29visual learningGO:00854210.7DRD3, DRD2, DRD1
30response to toxic substanceGO:00963610.7MAOB, DRD2, GPX1, NQO1
31learningGO:00761210.7HTR6, DRD3, COMT
32cerebral cortex GABAergic interneuron migrationGO:02185310.7DRD2, DRD1
33monoterpenoid metabolic processGO:01609810.7CYP2D6, CYP1A2
34xenobiotic metabolic processGO:00680510.7MAOB, CYP2D6, CYP1A2, NQO1, COMT
35heterocycle metabolic processGO:04648310.7CYP1A2, CYP2D6
36response to lipopolysaccharideGO:03249610.6CYP1A2, MAOB, SOD2, COMT
37mating behaviorGO:00761710.6MTNR1A, DRD1
38peristalsisGO:03043210.6DRD2, DRD1
39response to estradiol stimulusGO:03235510.6HTR6, CYP1A2, NQO1
40phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.6DRD2, DRD1
41behavioral response to ethanolGO:04814910.6DRD2, DRD4
42regulation of dopamine metabolic processGO:04205310.5DRD4, DRD1
43synaptic transmissionGO:00726810.5HTR6, COMT, HTR2A, HTR2C, MTNR1B
44hydrogen peroxide biosynthetic processGO:05066510.5SOD2, CYP1A2
45response to drugGO:04249310.5DRD2, MAOB, DRD3, DRD1, HTR6, HTR2A
46oxidative demethylationGO:07098910.5CYP1A2, CYP2D6
47adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.4DRD3, DRD1
48negative regulation of synaptic transmission, glutamatergicGO:05196710.4DRD2, HTR2A
49response to ethanolGO:04547110.2DRD3, NQO1, MAOB
50small molecule metabolic processGO:0442819.9MAOB, GPX1, CYP2D6, CYP1A2, NQO1, COMT

Molecular functions related to Tardive Dyskinesia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.5DRD2, DRD3, DRD4
2dopamine bindingGO:03524010.5DRD4, DRD3, DRD2, DRD1
31-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindingGO:07188610.4HTR2A, HTR2C
4serotonin receptor activityGO:00499310.4HTR6, HTR2A, HTR2C
5drug bindingGO:00814410.4SIGMAR1, HTR2C, HTR2A, DRD2, DRD3, DRD4
6melatonin receptor activityGO:00850210.4MTNR1B, MTNR1A
7serotonin bindingGO:05137810.4HTR2A, HTR2C
8dopamine neurotransmitter receptor activityGO:00495210.3DRD1, DRD4
9superoxide dismutase activityGO:00478410.1NQO1, SOD2

Products for genes affiliated with Tardive Dyskinesia

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Sources for Tardive Dyskinesia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
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