TD
MCID: TRD006
MIFTS: 54

Tardive Dyskinesia (TD) malady

Oral category

Summaries for Tardive Dyskinesia

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Tardive dyskinesia is a neurological syndrome caused by the long-term use of neuroleptic drugs. Neuroleptic drugs are generally prescribed for psychiatric disorders, as well as for some gastrointestinal and neurological disorders. Tardive dyskinesia is characterized by repetitive, involuntary, purposeless movements. Features of the disorder may include grimacing, tongue protrusion, lip smacking, puckering and pursing, and rapid eye blinking. Rapid movements of the arms, legs, and trunk may also occur. Involuntary movements of the fingers may be present.

MalaCards: Tardive Dyskinesia, also known as lingual-facial-buccal dyskinesia, is related to bipolar disorder and alzheimer's disease. An important gene associated with Tardive Dyskinesia is NQO1 (NAD(P)H dehydrogenase, quinone 1), and among its related pathways are Doxepin Pathway, Pharmacokinetics and Ifosfamide Pathway, Pharmacokinetics. The compounds remoxipride and duloxetine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and t cells, and related mouse phenotypes are adipose tissue and immune system.

Wikipedia:64 Tardive dyskinesia /ˈtɑrdɨv ˌdɪskɨˈniːʒə/ is a difficult-to-treat and often incurable form of... more...

Aliases & Classifications for Tardive Dyskinesia

Sources:
43NIH Rare Diseases, 44NINDS, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral


Aliases & Descriptions:

tardive dyskinesia 43 44
lingual-facial-buccal dyskinesia 61
thanatophoric dysplasia, type i 61
linguofacial dyskinesia 43
tardive oral dyskinesia 43
tardive dystonia 43
td 43


Related Diseases for Tardive Dyskinesia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Tardive Dyskinesia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1bipolar disorder30.4HTR2A, DRD2
2alzheimer's disease30.4CYP2D6, DRD2, HTR2C, SOD2, HSPG2, MTNR1A
3parkinson's disease30.2DRD2, DRD3, MAOB, CYP2D6, COMT
4schizoaffective disorder30.2DRD4, CYP2D6, DRD2, DRD3, COMT, HTR2A
5huntington's disease30.2MAOB, DRD1, DRD2
6colorectal cancer30.1NQO1, CYP1A2, CYP2D6, DRD2, COMT
7gilles de la tourette syndrome29.9DRD4, DRD2
8attention deficit hyperactivity disorder29.9COMT, HTR2C, HTR2A, DRD1, DRD2, DRD4
9lingual-facial-buccal dyskinesia10.7
10drug induced dyskinesia10.6
11diphtheria10.4
12tetanus10.4
13thanatophoric dysplasia10.3
14thanatophoric dysplasia type 210.3
15thanatophoric dysplasia type 110.3
16achondroplasia10.3
17syndactyly10.3
18hypochondroplasia10.3
19platyspondylic lethal skeletal dysplasia torrance type10.3
20mitochondrial disorders10.2
21major depressive disorder10.1
22myelitis10.1
23lewy body dementia10.1
24blepharospasm10.1
25anosognosia10.1
26bipolar i disorder10.1
27rocky mountain spotted fever10.1
28olecranon bursitis10.1
29brain disease10.1
30spotted fever10.1
31tic disorder10.1
32developmental disabilities10.1
33childhood-onset schizophrenia10.1
34m�ni�re disease10.1
35back pain10.1
36dysphagia10.1
37schizophrenia 1510.1
38diffuse idiopathic skeletal hyperostosis10.1
39spasmodic dysphonia10.1
40cervical dystonia10.1
41hepatitis d10.1
42restless legs syndrome10.0DRD2
43cocaine dependence10.0DRD2, DRD3
44blindness10.0MAOB
45myoclonus-dystonia10.0DRD2
46alexithymia10.0ANKK1
47neuroleptic malignant syndrome10.0DRD2, CYP2D6
48substance abuse10.0DRD2, DRD3, DRD4
49delusional disorder10.0DRD4, DRD2
50nicotine dependence10.0ANKK1, DRD4, DRD2

Graphical network of the top 20 diseases related to Tardive Dyskinesia:



Diseases related to tardive dyskinesia

Clinical Features for Tardive Dyskinesia

Drugs & Therapeutics for Tardive Dyskinesia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Tardive Dyskinesia

Drug clinical trials:

Search ClinicalTrials for Tardive Dyskinesia

Search NIH Clinical Center for Tardive Dyskinesia

Search CenterWatch for Tardive Dyskinesia

Genetic Tests for Tardive Dyskinesia

Anatomical Context for Tardive Dyskinesia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Tardive Dyskinesia:

33
Brain, Cortex, T cells, B cells, Endothelial, Globus pallidus, Subthalamic nucleus, Tongue

Animal Models for Tardive Dyskinesia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Tardive Dyskinesia

Sources:
51PubMed
See all sources

Articles related to Tardive Dyskinesia:

(show top 50)    (show all 534)
idTitleAuthorsYear
1
Tardive dyskinesia syndromes: current concepts. (24262160)
2014
2
The relevance of EEG artifact identification: a case of "delta-wave blinking" due to tardive dyskinesia. (23422518)
2013
3
Aripiprazole induced tardive dyskinesia--accruing evidence. (22990431)
2013
4
Tardive dyskinesia is associated with greater cognitive impairment in schizophrenia. (23827756)
2013
5
Electroconvulsive therapy for a patient with persistent tardive dyskinesia: a case report and literature review. (23965612)
2013
6
The metoclopramide black box warning for tardive dyskinesia: effect on clinical practice, adverse event reporting, and prescription drug lawsuits. (23735907)
2013
7
Tardive dyskinesia from atypical antipsychotic agents in patients with mood disorders in a clinical setting. (23726783)
2013
8
Parallels between behavioral and neurochemical variability in the rat vacuous chewing movement model of tardive dyskinesia. (22503783)
2012
9
Tardive dyskinesia is caused by maladaptive synaptic plasticity: a hypothesis. (22865512)
2012
10
Tardive dyskinesia: treatment with aripiprazole. (23430384)
2011
11
Surgery for tardive dyskinesia. (21907092)
2011
12
Analysis of genetic variations in the dopamine D1 receptor (DRD1) gene and antipsychotics-induced tardive dyskinesia in schizophrenia. (21181138)
2011
13
Subjective awareness of tardive dyskinesia and insight in schizophrenia. (20615668)
2011
14
Calcium channel blockers for neuroleptic-induced tardive dyskinesia. (22071797)
2011
15
A candidate gene study of Tardive dyskinesia in the CATIE schizophrenia trial. (19475583)
2010
16
Signs of striatal dopamine transporter density increase in association with improvement of tardive dyskinesia in a patient with schizophrenia, as demonstrated by a DAT scan. (19740630)
2010
17
Effect of alpha lipoic acid on the tardive dyskinesia and oxidative stress induced by haloperidol in rats. (19444377)
2009
18
No Evidence for Association between Tyrosine Hydroxylase Gene Val81Met Polymorphism and Susceptibility to Tardive Dyskinesia in Schizophrenia. (20046383)
2009
19
Effect of donepezil on tardive dyskinesia. (19142126)
2009
20
Aripiprazole (abilify) and tardive dyskinesia. (19749988)
2008
21
Pyridoxal plasma level in schizophrenic and schizoaffective patients with and without tardive dyskinesia. (18670243)
2008
22
Botulinum toxin in the treatment of orofacial tardive dyskinesia: a single blind study. (18022743)
2008
23
The coding-synonymous polymorphism rs1045280 (Ser280Ser) in beta-arrestin 2 (ARRB2) gene is associated with tardive dyskinesia in Chinese patients with schizophrenia. (19049562)
2008
24
A case of sodium oxybate treatment of tardive dyskinesia and bipolar disorder. (18681764)
2008
25
Support for an association of the C939T polymorphism in the human DRD2 gene with tardive dyskinesia in schizophrenia. (17669630)
2007
26
Ziprasidone-induced tardive dyskinesia in a patient without known risk factors. (18254531)
2007
27
Meta-analysis of two dopamine D2 receptor gene polymorphisms with tardive dyskinesia in schizophrenia patients. (17767146)
2007
28
Mood improvement after deep brain stimulation of the internal globus pallidus for tardive dyskinesia in a patient suffering from major depression. (16962613)
2007
29
Tardive dyskinesia in schizophrenia is associated with prolactin-related sexual disturbances. (16482082)
2006
30
Amisulpride-induced tardive dyskinesia. (16963229)
2006
31
Haplotype analysis of endothelial nitric oxide synthase (NOS3) genetic variants and tardive dyskinesia in patients with schizophrenia. (16495774)
2006
32
Manganese superoxide dismutase gene (MnSOD) polimorphism in schizophrenics with tardive dyskinesia from central Poland]. (17217237)
2006
33
Negative association between catechol-O-methyltransferase (COMT) gene Val158Met polymorphism and persistent tardive dyskinesia in schizophrenia. (15583953)
2005
34
Tardive dyskinesia predicts prolactin response to buspirone challenge in people with schizophrenia. (15939977)
2005
35
Olanzapine treatment for tardive dyskinesia in schizophrenia patients: a prospective clinical trial with patients randomized to blinded dose reduction periods. (15380859)
2004
36
Genetic association analysis of functional polymorphisms in the cytochrome P450 1A2 (CYP1A2) gene with tardive dyskinesia in Japanese patients with schizophrenia. (15564895)
2004
37
Association analysis of the dopamine D3 receptor gene ser9gly and brain-derived neurotrophic factor gene val66met polymorphisms with antipsychotic-induced persistent tardive dyskinesia and clinical expression in Chinese schizophrenic patients. (15626824)
2004
38
Analogue functional analysis of movements associated with tardive dyskinesia. (15529895)
2004
39
Mu opioid receptor gene polymorphism and neuroleptic-induced tardive dyskinesia in patients with schizophrenia. (14623376)
2003
40
Role of aging and striatal nitric oxide synthase activity in an animal model of tardive dyskinesia. (12909284)
2003
41
On Johnson M, Wester K: Full remission of tardive dyskinesia following general anaesthesia. (12749319)
2003
42
Tardive dyskinesia is not associated with the polymorphisms of 5-HT2A receptor gene, serotonin transporter gene and catechol-o-methyltransferase gene. (12711403)
2003
43
Genetic association analysis of 5-HT(6) receptor gene polymorphism (267C/T) with tardive dyskinesia. (12057822)
2002
44
Improvement of tardive dyskinesia following switch from neuroleptics to olanzapine. (12188112)
2002
45
Full remission of tardive dyskinesia following general anaesthesia. (12021954)
2002
46
Neural damage in the lenticular nucleus linked with tardive dyskinesia in schizophrenia: a preliminary study using proton magnetic resonance spectroscopy. (12223259)
2002
47
Tardive dyskinesia--diagnostic issues, subsyndromes, and concurrent movement disorders: a study of state hospital inpatients referred to a movement disorder consultation service. (11824487)
2001
48
Miscellaneous treatments for neuroleptic-induced tardive dyskinesia. (10796325)
2000
49
Association of the MscI polymorphism of the dopamine D3 receptor gene with tardive dyskinesia in schizophrenia. (10379516)
1999
50
Tardive dyskinesia due to Rocky Mountain spotted fever: case report. (3617898)
1987

Genetic Variations for Tardive Dyskinesia

Expression for genes affiliated with Tardive Dyskinesia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Tardive Dyskinesia

Search GEO for disease gene expression data for Tardive Dyskinesia.

Pathways for genes affiliated with Tardive Dyskinesia

Sources:
50PharmGKB, 12EMD Millipore, 38NCBI BioSystems Database, 54Reactome, 52QIAGEN, 30KEGG
See all sources

Pathways related to Tardive Dyskinesia according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4CYP2D6, CYP1A2
2
Hide members
10.4CYP1A2, CYP2D6
3
Hide members
10.4CYP1A2, CYP2D6
4
Acetaminophen metabolism
Hide members
10.4CYP2D6, NQO1, CYP1A2
510.4DRD4, DRD3, HTR2A
6
Hide members
10.3COMT, CYP1A2, NQO1
710.3DRD1, DRD2, DRD4
8
Hide members
10.3COMT, CYP2D6, CYP1A2
910.3GPX1, SOD2, NQO1
10
Hide members
10.3MAOB, CYP1A2, CYP2D6
1110.3DRD4, DRD3, DRD1, DRD2
1210.3DRD3, DRD4, DRD1, DRD2
13
Hide members
10.3DRD2, DRD1, DRD3, DRD4
14
Hide members
10.3DRD1, DRD3, DRD4, DRD2
15
Hide members
10.3CYP1A2, CYP2D6, NQO1, COMT
16
Hide members
10.3CYP2D6, CYP1A2, COMT, MAOB
17
Hide members
10.3HTR2C, DRD2, HTR2A, DRD1
1810.3HTR2C, DRD1, HTR2A, HTR6
19
Hide members
10.1HTR2C, DRD4, DRD3, DRD2, DRD1, HTR2A
20
Hide members
10.0DRD3, HTR6, HTR2C, HTR2A, DRD1, MTNR1A
21
Hide members
10.0MTNR1A, MTNR1B, DRD4, HSPG2, HTR2C, DRD3
22
Hide members
9.9DRD4, HTR2C, HTR2A, HTR6, DRD1, COMT

Compounds for genes affiliated with Tardive Dyskinesia

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 24HMDB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Tardive Dyskinesia according to GeneCards/GeneDecks:

(show top 50)    (show all 351)
idCompoundScoreTop Affiliating Genes
1remoxipride45 1111.7HTR2A, DRD2, DRD3, DRD4, CYP2D6, SIGMAR1
2duloxetine45 50 29 1113.6HTR2C, HTR2A, HTR6, DRD3, CYP1A2, CYP2D6
3pramipexole45 50 29 1113.6DRD2, DRD3, DRD4, DRD1, HTR2A, HTR2C
4loxapine29 45 1112.6DRD4, DRD2, DRD1, HTR2C, HTR2A, HTR6
5rotigotine45 29 1112.6DRD1, DRD2, DRD4, MAOB, CYP1A2, CYP2D6
6perphenazine50 29 45 1113.6HTR2C, HTR2A, HTR6, DRD1, DRD2, CYP1A2
7iloperidone50 45 29 1113.6HTR2A, HTR6, DRD1, DRD2, DRD3, DRD4
8fluphenazine29 45 1112.6HTR2A, HTR6, DRD1, DRD2, DRD4, CYP1A2
9thioridazine29 45 50 1113.5HTR2C, HTR2A, HTR6, DRD1, DRD2, CYP1A2
10paliperidone45 1111.5CYP2D6, HTR2C, HTR2A, DRD1, DRD2, DRD3
11Methotrimeprazine1110.5HTR2C, HTR2A, DRD1, DRD2, DRD3, DRD4
12quetiapine45 50 29 11 2414.5HTR2C, HTR2A, HTR6, DRD1, DRD2, DRD3
13aripiprazole29 50 45 11 2414.5HTR2C, HTR2A, HTR6, DRD1, DRD2, DRD3
14spiperone29 4511.5DRD2, HTR2A, DRD4, DRD3, DRD1, HTR2C
15ziprasidone50 29 45 1113.5HTR2C, HTR2A, HTR6, DRD1, DRD2, DRD3
16(+)-butaclamol29 4511.5HTR2A, DRD1, DRD2, DRD3, DRD4
176-hydroxydopamine4510.5COMT, SOD2, DRD1, DRD2, DRD3, DRD4
18methylphenidate45 50 1112.5COMT, CYP2D6, DRD1, MAOB, DRD4, DRD2
19methamphetamine45 50 1112.5COMT, SOD2, DRD1, DRD2, DRD4, MAOB
20cabergoline29 45 1112.5HTR2C, COMT, HTR2A, DRD1, DRD2, DRD3
21bupropion45 50 11 2413.5COMT, ANKK1, DRD2, DRD3, MAOB, CYP1A2
22promazine45 1111.5DRD4, HTR2A, DRD2, HTR2C, CYP1A2, DRD1
23apomorphine45 29 1112.5HTR2C, HTR2A, DRD1, DRD2, DRD3, DRD4
24haloperidol45 29 2 50 1114.5DRD3, DRD4, MAOB, CYP1A2, CYP2D6, SIGMAR1
25thiothixene29 1111.5DRD2, CYP1A2, DRD1, HTR2A, CYP2D6
26pergolide29 45 1112.5DRD4, HTR2A, HTR2C, COMT, CYP2D6, DRD3
27quinpirole45 2911.5HTR2A, DRD1, DRD4, DRD2, DRD3, HTR2C
28asenapine29 1111.5HTR2C, HTR2A, HTR6, DRD1, DRD2, DRD3
29lisuride29 45 1112.5DRD2, DRD3, DRD1, HTR6, HTR2A, HTR2C
30agomelatine29 45 1112.5CYP1A2, HTR2C, MTNR1B, MTNR1A, HTR2A
31maoa4510.5HTR2A, DRD2, HTR2C, COMT, DRD4, MAOB
32risperidone29 45 50 60 11 2415.5COMT, HTR2C, HTR2A, HTR6, DRD1, DRD2
33chlorpromazine45 29 50 1113.4HTR2C, HTR2A, HTR6, DRD1, DRD2, DRD3
34antipsychotics5010.4HTR2C, COMT, CYP1A2, ANKK1, DRD2
35ropinirole45 1111.4DRD4, MAOB, CYP1A2, CYP2D6, DRD3, DRD2
36olanzapine50 45 29 11 2414.4HTR6, DRD1, DRD2, DRD3, DRD4, ANKK1
37clozapine45 29 50 1113.4COMT, HTR2C, HTR2A, HTR6, DRD1, DRD2
38cocaine45 1111.4MAOB, DRD4, DRD3, CYP2D6, SIGMAR1, DRD2
39Pipotiazine1110.4CYP2D6, HTR2A, DRD2, DRD1, CYP1A2
40nicotine45 50 29 1113.4DRD4, COMT, DRD1, DRD2, DRD3, MAOB
41norepinephrine45 11 2412.4CYP1A2, NQO1, MAOB, HTR2C, HTR2A, HTR6
42bromocriptine29 45 1112.4DRD4, CYP1A2, DRD1, DRD3, DRD2, COMT
43minaprine45 1111.3HTR2C, HTR2A, DRD1, DRD2, CYP2D6
44paroxetine45 50 29 1113.3CYP2D6, CYP1A2, DRD4, DRD3, COMT, HTR2A
455-hydroxytryptamine4510.3DRD2, HTR6, HTR2A, COMT, HSPG2, HTR2C
46raclopride45 2911.3DRD2, HTR2A, DRD1, DRD3, DRD4
47amoxapine45 29 1112.2DRD2, DRD1, HTR6, HTR2A, CYP2D6
48dopamine45 29 11 2413.2COMT, SOD2, HTR2C, HTR2A, HTR6, DRD1
49roxindole29 4511.2HTR2C, HTR2A, DRD4, DRD3, DRD2
50levodopa45 1110.9MAOB, DRD4, CYP2D6, DRD3, DRD2, DRD1

GO Terms for genes affiliated with Tardive Dyskinesia

Sources:
16Gene Ontology
See all sources

Cellular components related to Tardive Dyskinesia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588610.0COMT, HSPG2, MTNR1B, DRD4, DRD3, DRD2
2integral to plasma membraneGO:0058879.7HTR2C, MTNR1A, MTNR1B, DRD4, DRD3, DRD2

Biological processes related to Tardive Dyskinesia according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idNameGO IDScoreTop Affiliating Genes
1response to histamineGO:03477610.8DRD2, DRD3, DRD4
2adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.8DRD3, DRD2, DRD4
3regulation of dopamine uptake involved in synaptic transmissionGO:05158410.8DRD3, DRD2, DRD1
4negative regulation of protein secretionGO:05070910.8DRD4, DRD3, DRD2
5arachidonic acid secretionGO:05048210.8DRD2, DRD4, DRD3
6alkaloid metabolic processGO:00982010.8CYP2D6, CYP1A2
7regulation of dopamine secretionGO:01405910.8HTR2A, DRD3, DRD2
8dopamine metabolic processGO:04241710.8DRD2, DRD4, DRD3, DRD1
9positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.8DRD2, DRD4
10prepulse inhibitionGO:06013410.8DRD3, DRD1, DRD2
11behavioral response to cocaineGO:04814810.8DRD2, DRD1, DRD4, DRD3
12synaptic transmission, dopaminergicGO:00196310.8DRD3, DRD4, DRD2, DRD1
13negative regulation of voltage-gated calcium channel activityGO:190138610.8DRD2, DRD4
14negative regulation of adenylate cyclase activityGO:00719410.8DRD4, DRD3, DRD2
15negative regulation of dopamine receptor signaling pathwayGO:06016010.7DRD3, DRD2
16phospholipase C-activating serotonin receptor signaling pathwayGO:00720810.7HTR2C, HTR2A
17response to amphetamineGO:00197510.7DRD4, DRD3, DRD2, DRD1
18response to selenium ionGO:01026910.7MAOB, SOD2, GPX1
19elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.7HTR2C, DRD2, DRD1
20behavioral fear responseGO:00166210.7DRD4, HTR2C, DRD1
21temperature homeostasisGO:00165910.7GPX1, HTR2A, DRD2, DRD1
22regulation of cAMP metabolic processGO:03081410.7DRD2, DRD3
23release of sequestered calcium ion into cytosolGO:05120910.7DRD2, HTR2A, HTR2C
24positive regulation of phosphatidylinositol biosynthetic processGO:01051310.7HTR2A, HTR2C
25drug catabolic processGO:04273710.7CYP2D6, CYP1A2
26G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.7HTR6, MTNR1B, DRD1, MTNR1A
27cellular calcium ion homeostasisGO:00687410.7HTR2A, DRD3, DRD2, HTR2C, DRD4
28locomotory behaviorGO:00762610.7SOD2, HTR2C, DRD2, DRD3
29visual learningGO:00854210.7DRD3, DRD2, DRD1
30response to toxic substanceGO:00963610.7MAOB, DRD2, GPX1, NQO1
31learningGO:00761210.7HTR6, DRD3, COMT
32cerebral cortex GABAergic interneuron migrationGO:02185310.7DRD2, DRD1
33monoterpenoid metabolic processGO:01609810.7CYP2D6, CYP1A2
34xenobiotic metabolic processGO:00680510.7MAOB, CYP2D6, CYP1A2, NQO1, COMT
35heterocycle metabolic processGO:04648310.7CYP1A2, CYP2D6
36response to lipopolysaccharideGO:03249610.6CYP1A2, MAOB, SOD2, COMT
37mating behaviorGO:00761710.6MTNR1A, DRD1
38peristalsisGO:03043210.6DRD2, DRD1
39response to estradiol stimulusGO:03235510.6HTR6, CYP1A2, NQO1
40phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.6DRD2, DRD1
41behavioral response to ethanolGO:04814910.6DRD2, DRD4
42regulation of dopamine metabolic processGO:04205310.5DRD4, DRD1
43synaptic transmissionGO:00726810.5HTR6, COMT, HTR2A, HTR2C, MTNR1B
44hydrogen peroxide biosynthetic processGO:05066510.5SOD2, CYP1A2
45response to drugGO:04249310.5DRD2, MAOB, DRD3, DRD1, HTR6, HTR2A
46oxidative demethylationGO:07098910.5CYP1A2, CYP2D6
47adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.4DRD3, DRD1
48negative regulation of synaptic transmission, glutamatergicGO:05196710.4DRD2, HTR2A
49response to ethanolGO:04547110.2DRD3, NQO1, MAOB
50small molecule metabolic processGO:0442819.9MAOB, GPX1, CYP2D6, CYP1A2, NQO1, COMT

Molecular functions related to Tardive Dyskinesia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.5DRD4, DRD3, DRD2
2dopamine bindingGO:03524010.5DRD4, DRD3, DRD2, DRD1
31-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindingGO:07188610.4HTR2A, HTR2C
4serotonin receptor activityGO:00499310.4HTR2C, HTR2A, HTR6
5drug bindingGO:00814410.4DRD3, SIGMAR1, DRD4, DRD2, HTR2A, HTR2C
6melatonin receptor activityGO:00850210.4MTNR1B, MTNR1A
7serotonin bindingGO:05137810.4HTR2A, HTR2C
8dopamine neurotransmitter receptor activityGO:00495210.3DRD4, DRD1
9superoxide dismutase activityGO:00478410.1NQO1, SOD2

Products for genes affiliated with Tardive Dyskinesia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tardive Dyskinesia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet