TD
MCID: TRD006
MIFTS: 51

Tardive Dyskinesia (TD) malady

Rare diseases, Oral diseases categories
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Summaries for Tardive Dyskinesia

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44NINDS, 65Wikipedia, 33MalaCards
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NINDS:44 Tardive dyskinesia is a neurological syndrome caused by the long-term use of neuroleptic drugs. Neuroleptic drugs are generally prescribed for psychiatric disorders, as well as for some gastrointestinal and neurological disorders. Tardive dyskinesia is characterized by repetitive, involuntary, purposeless movements. Features of the disorder may include grimacing, tongue protrusion, lip smacking, puckering and pursing, and rapid eye blinking. Rapid movements of the arms, legs, and trunk may also occur. Involuntary movements of the fingers may be present.

MalaCards: Tardive Dyskinesia, also known as lingual-facial-buccal dyskinesia, is related to schizophrenia and mood disorder. An important gene associated with Tardive Dyskinesia is NQO1 (NAD(P)H dehydrogenase, quinone 1), and among its related pathways are AHR Pathway and Estrogen metabolism. The compounds nemonapride and eticlopride have been mentioned in the context of this disorder. Affiliated tissues include tongue, eye and brain, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Wikipedia:65 Tardive dyskinesia /?t?rd?v ?d?sk??ni???/ is a difficult-to-treat and often incurable form of... more...

Aliases & Classifications for Tardive Dyskinesia

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43NIH Rare Diseases, 44NINDS, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Oral diseases


Aliases & Descriptions:

tardive dyskinesia 43 44
lingual-facial-buccal dyskinesia 62
thanatophoric dysplasia, type i 62
linguofacial dyskinesia 43
tardive oral dyskinesia 43
tardive dystonia 43
td 43


Related Diseases for Tardive Dyskinesia

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17GeneCards, 18GeneDecks
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Diseases related to Tardive Dyskinesia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.5CYP1A2, NQO1, DRD4, DRD3, DRD1, CYP2D6
2mood disorder30.6DRD1, DRD3, DRD4
3parkinson's disease30.3CYP2D6, DRD3
4gilles de la tourette syndrome30.2DRD1, DRD3, DRD4
5alzheimer's disease30.2DRD3, DRD4, HSPG2, NQO1, CYP2D6, DRD1
6hepatitis30.2CYP2D6, HSPG2, CYP1A2
7schizoaffective disorder30.2DRD3, DRD4, CYP2D6
8bipolar disorder30.1DRD3, HSPG2, DRD4, DRD1
9blindness10.7
10dystonia10.6
11neuronitis10.3
12huntington's disease10.3
13dementia10.3
14hypothyroidism10.3
15intellectual disability10.3
16drug induced dyskinesia10.3
17myelitis10.2
18major depressive disorder10.2
19anosognosia10.2
20blepharospasm10.2
21rocky mountain spotted fever10.2
22olecranon bursitis10.2
23lewy body dementia10.2
24cerebritis10.2
25bursitis10.2
26cataract10.2
27cervicitis10.2
28megacolon10.2
29multiple sclerosis10.2
30spotted fever10.2
31developmental disabilities10.2
32childhood-onset schizophrenia10.2
33back pain10.2
34dysphagia10.2
35endotheliitis10.2
36diffuse idiopathic skeletal hyperostosis10.1
37cervical dystonia10.1
38hyperostosis10.1
39spasmodic dysphonia10.1
40delusional disorder10.1DRD4
41neuroleptic malignant syndrome10.0CYP2D6
42drug addiction10.0DRD3, DRD1
43personality disorder10.0DRD3, DRD4
44substance dependence10.0DRD4, DRD3
45heroin dependence10.0ANKK1, DRD4
46substance abuse10.0DRD3, DRD4
47nicotine dependence10.0ANKK1, DRD4
48aplastic anemia10.0CYP2D6, NQO1
49pathological gambling10.0DRD1, DRD4, DRD3
50obsessive-compulsive disorder10.0DRD1, DRD4, DRD3

Graphical network of the top 20 diseases related to Tardive Dyskinesia:



Diseases related to tardive dyskinesia

Symptoms for Tardive Dyskinesia

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Drugs & Therapeutics for Tardive Dyskinesia

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Tardive Dyskinesia

Search NIH Clinical Center for Tardive Dyskinesia

Genetic Tests for Tardive Dyskinesia

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Anatomical Context for Tardive Dyskinesia

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33MalaCards
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MalaCards organs/tissues related to Tardive Dyskinesia:

33
Tongue, Eye, Brain, Globus pallidus, Cortex, Testes, Endothelial

Animal Models for Tardive Dyskinesia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Tardive Dyskinesia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7CYP1A2, NQO1, HSPG2, DRD4, DRD3, DRD1
2MP:00053867.4CYP1A2, HSPG2, DRD4, DRD3, DRD1, SIGMAR1

Publications for Tardive Dyskinesia

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52PubMed
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Articles related to Tardive Dyskinesia:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Dehydroepiandrosterone sulphate as a putative protective factor against tardive dyskinesia. (24389397)
2014
2
Structural brain changes associated with tardive dyskinesia in schizophrenia. (23222039)
2013
3
The relevance of EEG artifact identification: a case of "delta-wave blinking" due to tardive dyskinesia. (23422518)
2013
4
New and emerging treatments for symptomatic tardive dyskinesia. (24235816)
2013
5
Tardive dyskinesia in schizophrenia. (23818532)
2013
6
Do tardive dyskinesia and L-dopa induced dyskinesia share common genetic risk factors? An exploratory study. (23666822)
2013
7
Zolpidem improves tardive dyskinesia and akathisia. (23637028)
2013
8
Aquaporin-4 knockout abolishes apomorphine-induced tardive dyskinesia following chronic treatment with neuroleptics. (23126383)
2012
9
Tetrabenazine for the treatment of tardive dyskinesia. (21487088)
2011
10
Tardive dyskinesia. (21365202)
2011
11
Alpha-phenyl-N-tert-butylnitrone prevents oxidative stress in a haloperidol-induced animal model of tardive dyskinesia: investigating the behavioural and biochemical changes. (21816389)
2011
12
Tardive dyskinesia: treatment with aripiprazole. (23430384)
2011
13
Rational antipsychotic choice: weighing the risk of tardive dyskinesia and metabolic syndrome. (21916828)
2011
14
Treatment outcomes of patients with tardive dyskinesia and chronic schizophrenia. (20816031)
2011
15
Phosphodiesterase 4B genetic variants are not associated with antipsychotic-induced tardive dyskinesia. (20436352)
2010
16
Dysphagia due to tardive dyskinesia. (22174539)
2010
17
Rapid improvement of neuroleptic-induced tardive dyskinesia with levetiracetam in an interictal psychotic patient. (20520300)
2010
18
A randomized controlled trial of risperidone and olanzapine for schizophrenic patients with neuroleptic-induced tardive dyskinesia. (20441726)
2010
19
Association study of tardive dyskinesia and five DRD4 polymorphisms in schizophrenia patients. (19238168)
2009
20
MDR1 gene in tardive dyskinesia scale scores: comparison of strategies for quantitative trait haplotype analysis. (19282152)
2009
21
Motor worsening and tardive dyskinesia with aripiprazole in Lewy body dementia. (21686897)
2009
22
Analysis of genetic variations in the RGS9 gene and antipsychotic-induced tardive dyskinesia in schizophrenia. (18548510)
2009
23
Neuroleptic induced tardive dyskinesia in a patient on treatment for schizophrenia: case report. (20499786)
2009
24
Aripiprazole improves neuroleptic-associated tardive dyskinesia, but it does not meliorate psychotic symptoms. (18433967)
2008
25
Pain and denture condition in edentulous orodyskinesia: comparisons with tardive dyskinesia and control subjects. (18759358)
2008
26
Benign tongue FDG uptake in a patient with tardive dyskinesia. (18431151)
2008
27
Support for an association of the C939T polymorphism in the human DRD2 gene with tardive dyskinesia in schizophrenia. (17669630)
2007
28
Comparative assessment of the incidence and severity of tardive dyskinesia in patients receiving aripiprazole or haloperidol for the treatment of schizophrenia: a post hoc analysis. (18162021)
2007
29
Tardive dyskinesia circa 2006. (16877639)
2006
30
Multidose risperidone treatment evaluated in a rodent model of tardive dyskinesia. (16319911)
2006
31
Focus on lower risk of tardive dyskinesia with atypical antipsychotics. (16517454)
2006
32
The human dopamine receptor D2 (DRD2) gene is associated with tardive dyskinesia in patients with schizophrenia. (16769201)
2006
33
Improvement in tardive dyskinesia with aripiprazole use. (15830835)
2005
34
Association analysis of NAD(P)Hratioquinone oxidoreductase (NQO1) Pro187Ser genetic polymorphism and tardive dyskinesia in patients with schizophrenia in Taiwan. (15836802)
2005
35
Tardive dyskinesia in the era of typical and atypical antipsychotics. Part 2: Incidence and management strategies in patients with schizophrenia. (16363464)
2005
36
Tardive dyskinesia after long-term veralipride treatment. (15939983)
2005
37
Risperidone and olanzapine induced tardive dyskinesia : a critical review of reported cases. (21206790)
2004
38
Tardive dyskinesia in 2 patients treated with ziprasidone. (15644988)
2004
39
Mu opioid receptor gene polymorphism and neuroleptic-induced tardive dyskinesia in patients with schizophrenia. (14623376)
2003
40
Treatment-emergent tardive dyskinesia with quetiapine in mood disorders. (12920421)
2003
41
Interaction between polymorphisms of the dopamine D3 receptor and manganese superoxide dismutase genes in susceptibility to tardive dyskinesia. (12960753)
2003
42
Pathophysiology and drug therapy of tardive dyskinesia: current concepts and future perspectives. (12669107)
2003
43
Aripiprazole-induced improvement in tardive dyskinesia. (14733461)
2003
44
Quetiapine-induced improvement of tardive dyskinesia in three patients with schizophrenia. (12177588)
2002
45
Prevalence of tardive dyskinesia among psychiatric in-patients at Mathari Hospital, Nairobi. (12635762)
2002
46
Rapid onset of tardive dyskinesia in Huntington disease with olanzapine. (12172349)
2002
47
Tardive dyskinesia: legal issues and consent. (12774783)
2002
48
Lack of association between a functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene and tardive dyskinesia in schizophrenia. (11496364)
2001
49
Association between the serotonin 2A receptor gene and tardive dyskinesia in chronic schizophrenia. (11317227)
2001
50
Association of the MscI polymorphism of the dopamine D3 receptor gene with tardive dyskinesia in schizophrenia. (10379516)
1999

Variations for Tardive Dyskinesia

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Tardive Dyskinesia:

1 (show all 13)
id Gene Name Type Significance SNP ID Assembly Location
1FGFR3NM_000142.4(FGFR3): c.742C> T (p.Arg248Cys)single nucleotide variantPathogenicrs121913482GRCh37Chr 4, 1803564: 1803564
2FGFR3NM_000142.4(FGFR3): c.1111A> T (p.Ser371Cys)single nucleotide variantPathogenicrs121913484GRCh37Chr 4, 1806092: 1806092
3FGFR3NM_000142.4(FGFR3): c.2419T> G (p.Ter807Gly)single nucleotide variantPathogenicrs121913101GRCh37Chr 4, 1808987: 1808987
4FGFR3NM_000142.4(FGFR3): c.2419T> A (p.Ter807Arg)single nucleotide variantPathogenicrs121913101GRCh37Chr 4, 1808987: 1808987
5FGFR3NM_000142.4(FGFR3): c.2421A> T (p.Ter807Cys)single nucleotide variantPathogenicrs121913103GRCh37Chr 4, 1808989: 1808989
6FGFR3NM_000142.4(FGFR3): c.746C> G (p.Ser249Cys)single nucleotide variantPathogenicrs121913483GRCh37Chr 4, 1803568: 1803568
7FGFR3NM_000142.4(FGFR3): c.1949A> T (p.Lys650Met)single nucleotide variantPathogenicrs121913105GRCh37Chr 4, 1807890: 1807890
8FGFR3NM_000142.4(FGFR3): c.1118A> G (p.Tyr373Cys)single nucleotide variantPathogenicrs121913485GRCh37Chr 4, 1806099: 1806099
9FGFR3NM_000142.4(FGFR3): c.1108G> T (p.Gly370Cys)single nucleotide variantPathogenicrs121913479GRCh37Chr 4, 1806089: 1806089
10FGFR3NM_000142.4(FGFR3): c.2419T> C (p.Ter807Arg)single nucleotide variantPathogenicrs121913101GRCh37Chr 4, 1808987: 1808987
11FGFR3NM_000142.4(FGFR3): c.2420G> T (p.Ter807Leu)single nucleotide variantPathogenicrs397515514GRCh37Chr 4, 1808988: 1808988
12FGFR3NM_000142.4(FGFR3): c.2421A> C (p.Ter807Cys)single nucleotide variantPathogenicrs121913103GRCh37Chr 4, 1808989: 1808989
13FGFR3NM_000142.4(FGFR3): c.2421A> G (p.Ter807Trp)single nucleotide variantPathogenicrs121913103GRCh37Chr 4, 1808989: 1808989

Expression for genes affiliated with Tardive Dyskinesia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tardive Dyskinesia

Search GEO for disease gene expression data for Tardive Dyskinesia.

Pathways for genes affiliated with Tardive Dyskinesia

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Sources:
50PathCards, 53QIAGEN, 38NCBI BioSystems Database, 51PharmGKB, 30KEGG, 60Thomson Reuters, 55Reactome
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Pathways related to Tardive Dyskinesia according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
AhR pathway38
9.6NQO1, CYP1A2
2
Show member pathways
9.6NQO1, CYP1A2
39.3DRD4, DRD1
4
Show member pathways
Retinol metabolism60
9.1CYP1A2, CYP2D6
59.1CYP2D6, CYP1A2
6
Show member pathways
9.1CYP1A2, CYP2D6
7
Show member pathways
9.1CYP2D6, CYP1A2
8
Show member pathways
Nicotine Activity on Dopaminergic Neurons38
8.9DRD1, DRD3, DRD4
9
Show member pathways
8.9DRD1, DRD3, DRD4
10
Show member pathways
8.9DRD1, DRD3, DRD4
118.9DRD4, DRD3, DRD1
12
Show member pathways
8.8NQO1, CYP1A2, CYP2D6
13
Show member pathways
8.1CYP2D6, DRD4, DRD3, DRD1

Compounds for genes affiliated with Tardive Dyskinesia

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Sources:
45Novoseek, 51PharmGKB, 29IUPHAR, 11DrugBank, 3BitterDB, 24HMDB, 61Tocris Bioscience
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Compounds related to Tardive Dyskinesia according to GeneCards/GeneDecks:

(show top 50)    (show all 278)
idCompoundScoreTop Affiliating Genes
1nemonapride45 51 2911.3DRD3, ANKK1, DRD4
2eticlopride45 2910.3DRD1, DRD4, DRD3
3(+)-butaclamol45 2910.3DRD1, DRD4, DRD3
4sch 23390459.3DRD3, DRD1, DRD4
5raclopride45 2910.2DRD3, DRD4, DRD1
6spiperone45 2910.2DRD4, DRD3, DRD1
7sulpiride45 29 1111.1DRD3, DRD1, DRD4
8duloxetine45 51 29 1112.0CYP1A2, DRD3, CYP2D6
9dextromethorphan3 51 24 1112.0SIGMAR1, CYP1A2, CYP2D6
10promazine45 1110.0DRD1, DRD4, CYP1A2
116-hydroxydopamine459.0NQO1, DRD1, DRD3, DRD4
12thiothixene29 119.9CYP1A2, DRD1, CYP2D6
13pramipexole45 29 51 1111.9DRD4, DRD1, DRD3
14pimozide29 45 51 1111.9CYP1A2, DRD3, CYP2D6
15piperazine45 119.9CYP2D6, DRD4, DRD3
16quinpirole45 299.8DRD3, DRD4, DRD1
17chlorzoxazone45 29 1110.8CYP2D6, CYP1A2, NQO1
18bromocriptine45 29 1110.8DRD1, DRD3, DRD4, CYP1A2
19methylphenidate45 51 1110.7DRD4, DRD1, CYP2D6
20thioridazine29 45 51 1111.7CYP1A2, DRD1, CYP2D6
21antipsychotics518.7CYP2D6, HSPG2, ANKK1, CYP1A2
22remoxipride45 119.7DRD3, SIGMAR1, CYP2D6, DRD4
23perphenazine29 45 51 1111.7CYP1A2, CYP2D6, DRD1
24bupropion51 45 24 1111.7ANKK1, CYP1A2, DRD3, CYP2D6
25cabergoline45 29 1110.6DRD1, DRD3, DRD4
26domperidone45 29 1110.6CYP2D6, DRD1, CYP1A2, DRD3
27imipramine45 29 51 24 1112.5CYP2D6, DRD3, DRD1, CYP1A2
28lisuride45 29 1110.5DRD1, DRD3, DRD4, CYP2D6
29pergolide45 29 1110.5DRD4, DRD3, CYP2D6, DRD1
30aripiprazole29 45 51 24 1112.5DRD1, DRD3, CYP2D6, DRD4
31paroxetine45 51 29 1111.5CYP2D6, DRD4, CYP1A2, DRD3
32quetiapine45 51 29 24 1112.5CYP2D6, DRD4, DRD3, DRD1
33methamphetamine45 51 1110.5DRD1, DRD3, DRD4, CYP2D6
34fluphenazine29 45 51 1111.4CYP2D6, DRD1, CYP1A2, DRD4
35levodopa45 119.4CYP2D6, DRD4, DRD1, DRD3
36norepinephrine45 24 1110.4DRD1, DRD4, DRD3, CYP1A2, NQO1
37cocaine45 119.1DRD3, CYP2D6, DRD4, SIGMAR1, DRD1
38risperidone45 51 29 61 24 1113.1ANKK1, CYP2D6, DRD3, DRD4, DRD1
39rotigotine29 45 1110.0DRD4, DRD3, CYP1A2, CYP2D6, DRD1
40ropinirole45 119.0DRD1, DRD3, DRD4, CYP1A2, CYP2D6
41paliperidone45 119.0CYP1A2, DRD1, DRD4, DRD3, CYP2D6
42iloperidone51 45 29 1111.0CYP2D6, CYP1A2, DRD4, DRD3, DRD1
43asenapine29 119.0CYP1A2, DRD1, DRD4, DRD3, CYP2D6
44ziprasidone29 51 45 1111.0CYP1A2, DRD4, DRD3, DRD1, CYP2D6
45chlorpromazine29 45 51 1111.0DRD1, DRD4, CYP1A2, CYP2D6, DRD3
46haloperidol45 51 29 3 1111.7CYP1A2, DRD4, DRD3, DRD1, SIGMAR1, CYP2D6
47olanzapine45 51 29 24 1111.6CYP2D6, DRD1, CYP1A2, ANKK1, DRD4, DRD3
48clozapine45 29 51 1110.6DRD3, DRD4, ANKK1, CYP1A2, DRD1, CYP2D6
49nicotine45 29 51 1110.5DRD3, DRD4, CYP1A2, DRD1, ANKK1, CYP2D6
50dopamine45 29 24 1110.3DRD3, SIGMAR1, DRD1, DRD4, NQO1, CYP2D6

GO Terms for genes affiliated with Tardive Dyskinesia

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16Gene Ontology
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Cellular components related to Tardive Dyskinesia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.6SIGMAR1, DRD1, DRD3, DRD4
2endoplasmic reticulum membraneGO:0057898.0SIGMAR1, DRD1, CYP1A2, CYP2D6

Biological processes related to Tardive Dyskinesia according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine uptake involved in synaptic transmissionGO:0515849.9DRD1, DRD3
2adenylate cyclase-activating dopamine receptor signaling pathwayGO:0071919.8DRD3, DRD1
3response to histamineGO:0347769.8DRD3, DRD4
4adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:0071959.7DRD4, DRD3
5prepulse inhibitionGO:0601349.7DRD3, DRD1
6negative regulation of protein secretionGO:0507099.6DRD3, DRD4
7regulation of dopamine metabolic processGO:0420539.6DRD1, DRD4
8arachidonic acid secretionGO:0504829.6DRD3, DRD4
9visual learningGO:0085429.5DRD1, DRD3
10negative regulation of adenylate cyclase activityGO:0071949.5DRD4, DRD3
11alkaloid metabolic processGO:0098209.5CYP2D6, CYP1A2
12drug catabolic processGO:0427379.4CYP2D6, CYP1A2
13heterocycle metabolic processGO:0464839.4CYP2D6, CYP1A2
14monoterpenoid metabolic processGO:0160989.4CYP2D6, CYP1A2
15oxidative demethylationGO:0709899.4CYP1A2, CYP2D6
16behavioral fear responseGO:0016629.3DRD4, DRD1
17dopamine metabolic processGO:0424179.3DRD1, DRD3, DRD4
18synaptic transmission, dopaminergicGO:0019639.3DRD1, DRD3, DRD4
19behavioral response to cocaineGO:0481489.3DRD4, DRD3, DRD1
20response to amphetamineGO:0019759.3DRD1, DRD3, DRD4
21social behaviorGO:0351769.1DRD3, DRD4
22drug metabolic processGO:0171449.0CYP1A2, CYP2D6
23xenobiotic metabolic processGO:0068059.0NQO1, CYP1A2, CYP2D6

Molecular functions related to Tardive Dyskinesia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.3DRD4, DRD3
2dopamine neurotransmitter receptor activityGO:0049529.3DRD4, DRD1
3monooxygenase activityGO:0044979.1CYP1A2, CYP2D6
4dopamine bindingGO:0352409.0DRD1, DRD3, DRD4
5aromatase activityGO:0703308.8CYP1A2, CYP2D6
6drug bindingGO:0081448.4SIGMAR1, DRD3, DRD4, CYP2D6

Products for genes affiliated with Tardive Dyskinesia

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Sources for Tardive Dyskinesia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet